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Ronchi

Ronchi-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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In vitro epithelial models comprising lamina propria-derived cells
Emulate, Inc.
July 05, 2018 - N°20180185844

An in vitro microfluidic “organ-on-chip” is described herein that mimics the structure and at least one function of specific areas of the epithelial system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and the associated tissue specific epithelial cells and endothelial cells.
Methods of validating candidate compounds for use in treating copd and other diseases
The Trustees Columbia University In The City Of New York
June 21, 2018 - N°20180172705

The present invention relates to methods of diagnosing, monitoring, and treating elastin fiber injuries. In additional preferred embodiments, the present invention relates to methods of validating candidate compounds for use in treating chronic obstructive pulmonary disease (copd), chronic bronchitis, emphysema, refractory asthma, and other related diseases.
Bicyclic heteroaryl derivatives as cftr potentiators
Cystic Fibrosis Foundation Therapeutics, Inc.
June 21, 2018 - N°20180170938

The present invention relates to 1,3-disubstituted-1h-pyrazolo[3,4-d]pyrimidin-4-amine derivatives, 5,7-disubstituted-pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives or 5,7-disubstituted-imidazo[5,1-f][1,2,4]triazine-4-amine derivatives, and pharmaceutically acceptable salts thereof. The compounds are potentiators of cystic fibrosis transmembrane conductance regulator (cftr).
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Systems and methods for sympathetic cardiopulmonary neuromodulation
Reflex Medical, Inc.
May 31, 2018 - N°20180147260

Methods, devices and systems are described for decreasing the activity of the sympathetic nervous innervation to and from the lungs and the vessels supplying the lungs to treat pulmonary medical conditions such as asthma. In one embodiment, the method may involve advancing an intravascular instrument to a target location in a blood vessel within the intercostal vasculature to ablate either ...
3-(phenyl)-n-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide compounds for the management of cftr protein mediated ...
Emory University
May 31, 2018 - N°20180147190

This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (cftr) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary disease, chronic pancreatitis, chronic bronchitis, asthma, mucus formation, comprising administering an effective amount of a 3-(phenyl)-n-(4-phenoxybenzyl)-1,2,4-oxa-diazole-5-carboxamide compound, salt, or derivative thereof to a subject in need thereof. In certain embodiments, ...
Compounds, compositions, and methods for increasing cftr activity
Proteostasis Therapeutics, Inc.
May 31, 2018 - N°20180147187

The present disclosure features compounds such as those having the formulae (iia), (iib), (iic), (iid), (iiia), and (iiib), which can increase cystic fibrosis transmembrane conductance regulator (cftr) activity as measured in human bronchial epithelial (hbe) cells. The present disclosure also features methods of treating a condition associated with decreased cftr activity or a condition associated with a dysfunction of proteostasis ...
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Pyrrolopyrimidines as cftr potentiators
May 24, 2018 - N°20180141954

Wherein r1a, r1b, r2, r3, r4, w, y, and z are as described herein, and pharmaceutically acceptable salts thereof. The compounds are potentiators of cystic fibrosis transmembrane conductance regulator (cftr).
Amniotic fluid formulation for treatment of lung disorders
Mam Holdings Of West Florida, L.l.c.
May 24, 2018 - N°20180140641

Formulations of human amniotic fluid and methods of use thereof for treatment of lung disorders, and/or injuries have been developed. The formulations are suitable for topical delivery to the lung for treatment of lung disorders including chronic obstructive pulmonary disorders (copd), asthma, emphysema, bronchiectasis, chronic bronchitis, interstitial lung disease, alpha-1 antitrypsin emphysema, as well as for treatment of acute ...
System and method for bronchial dilation
Nuvaira, Inc.
May 17, 2018 - N°20180133475

A method of reducing bronchial constriction in a subject includes delivering energy to create one or more lesions on a main bronchus so as to transect pulmonary nerves sufficiently to reduce bronchial constriction in a lung of the patient distal to the main bronchus.. .
Immunogenic and vaccine compositions for use against bordetella bronchiseptica infection
Cyanimal Ip
May 17, 2018 - N°20180133301

The present invention in certain embodiments generally relates to an immunogenic composition comprising bordetella sp. Adenylate cyclase toxin (cyaa) for use in treating bordetella bronchiseptica infections in non-human animals.
Solanum dubium seeds and honey (extracted from bee hives in acacia tree populated area) combination ...
May 17, 2018 - N°20180133264

As a clinical trial for the combined ingredients, twenty five patients medically diagnosed as asthmatic were randomly selected and enrolled in the study; none of them is currently using anti-asthmatic drugs. Signs of asthma disappeared in the treated patients..
Lung volume-reducing elastic implant and instrument
Lifetech Scientific (shenzhen) Co., Ltd.
May 17, 2018 - N°20180132860

A lung volume-reducing elastic implant (2) and a lung volume-reducing instrument; the lung volume-reducing elastic implant (2) is tubular and comprises a proximal implant end (201), an elastic deformation part (205) and a distal implant end (202); the elastic deformation part (205) is located between the proximal implant end (201) and the distal implant end (202), and the elastic deformation part (205) has a shape memory characteristic; the lung ...
Pharmaceutical composition comprising glutarimide derivatives and use thereof in the treatment of eosinophilic diseases
Obschestvo S Ogranichennoi Otvetstvennostiyu "pharmenterprises"
April 19, 2018 - N°20180104230

The present invention relates to novel biologically active glutarimide derivatives of general formula (i) or a pharmaceutically acceptable salt thereof, their use as a therapeutic agent for the treatment of eosinophilic diseases, preferably of allergic nature, in particular bronchial asthma, allergic rhinitis, polypous rhinosinusopathies, eosinophilic colitis, eosinophilic syndrome, allergic conjunctivitis, atopic dermatitis, churg-strauss syndrome, anaphylactic shock, quincke's edema, eosinophilic vasculitis, ...
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Medical tubes for selective mechanical ventilation of the lungs
April 05, 2018 - N°20180093058

A single lumen endobronchial tube for selective mechanical ventilation of the lungs can include a medical tube having a single lumen with an opening at each of opposed distal and proximal ends of the tube, the opening at the proximal end of the tube being adapted for connection to an external mechanical ventilation device, and the opening at the distal ...
Pyrazolothiazole compound and medicine comprising same
April 05, 2018 - N°20180092919

The compound of the invention has jak1 inhibitory activity, and thus, immunosuppressive effect, anti-inflammatory effect and anti-proliferative effect, and is useful in the treatment of the diseases, for example, rheumatoid arthritis, inflammatory bowel disease, psoriasis and vasculitis, bronchial asthma, chronic obstructive pulmonary disease and eosinophilic sinusitis, nasal polyp.. .
High resistance implanted bronchial isolation devices and methods
Pulmonx Corporation
April 05, 2018 - N°20180092731

Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment.
System and method for cleansing segments of a luminal network
Covidien Lp
March 22, 2018 - N°20180078119

A method and system for instilling a medium into portions of a luminal network is provided. The method includes generating a model of a luminal network based on images of the luminal network, determining a location of a treatment target in the luminal network, navigating a bronchoscope through the bronchial tree to a target, guiding a catheter through the bronchoscope, ...
Compositions and methods for treating asthma and other lung diseases
The Trustees Of The University Of Pennsylvania
March 15, 2018 - N°20180071233

The present invention provides methods for dilating the bronchi or bronchioles and relaxing a pulmonary smooth muscle in a subject by treating the subject with a pharmaceutical composition, which includes a histone deacetylase (hdac) inhibitor. The ability to dilate the bronchi or bronchioles and relax a pulmonary smooth muscle according to the methods of the invention allows treating, alleviating, or ...
Ibv strains and uses thereof
Biomune Company
March 08, 2018 - N°20180066236

The present invention relates to novel infectious bronchitis virus strains and the uses thereof. The invention particularly relates to an inactivated or attenuated ibv, as well as to vaccine compositions comprising the same and the uses thereof to vaccinate avians.
Method and system for measuring pulmonary artery circulation information
Pneumrx, Inc.
March 08, 2018 - N°20180064411

Minimally invasive systems and methods are described for measuring pulmonary circulation information from the pulmonary arteries. A transbronchial doppler ultrasound catheter is advanced through the airways and in the vicinity of the pulmonary artery.
Methods of treatment of eosinophilic bronchitis with an anti-il-5 antibody
Glaxosmithkline Llc
March 01, 2018 - N°20180057582

The present invention relates generally to the methods for the treatment and diagnosis of conditions mediated by il-5 and excess eosinophil production, and more specifically to mabs, fabs, chimeric and humanized antibodies. More particularly, the present invention relates generally to the treatment of eosinophilic bronchitis with an anti-il-5 antibody or fragment thereof..
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