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Polymerase

Polymerase-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Diagnostic methods and compositions
Theranos, Inc.
August 09, 2018 - N°20180223381

Methods and compositions for the identification of genetic-related information are provided. At least portions of methods provided herein may be performed without thermocycling.
Stepwise sequencing by non-labeled reversible terminators or natural nucleotides
Bgi Shenzhen
August 09, 2018 - N°20180223358

The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent..
Recombinant polymerases for incorporation of protein shield nucleotide analogs
Pacific Biosciences Of California, Inc.
August 09, 2018 - N°20180223352

Provided are compositions comprising recombinant dna polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing or nucleic acid amplification. Such properties include enhanced performance with large nucleotide analogs, increased stability, increased readlength, and improved detection of modified bases, and can also include resistance to photodamage, ...
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Novel compounds for use in pcr systems and applications thereof
Life Technologies Corporation
August 09, 2018 - N°20180223334

This disclosure relates to novel compounds for use in various compositions, kits and methods, including, for example, use in polymerase storage buffers and in nucleic acid synthesis or amplification reactions such as a polymerase chain reaction (pcr). Methods for preparing the novel compounds are also described..
Nucleic acid sample preparation
Cambridge Epigenetix Limited
August 09, 2018 - N°20180223332

This invention relates to the preparation of nucleic acid samples for analysis. The invention may be particularly useful for single stranded samples.
Methods and compositions for size-controlled homopolymer tailing of substrate polynucleotides by a nucleic acid polymerase
Swift Biosciences, Inc.
August 09, 2018 - N°20180223321

The present invention is directed to methods and compositions for adding tails of specific lengths to a substrate poly—nucleotide. The invention also contemplates methods and compositions for immobilization of tailed substrates to a solid support.
Polymerase Patent Pack
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Polymerase Patent Applications
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inventor
  • 270+ full patent PDF documents of Polymerase-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Combined inhibition of the vitamin d receptor and poly(adp) ribose polymerase (parp) in the ...
Institute For Cancer Research D/b/a The Research Institute Of Fox Chase Cancer Center
August 09, 2018 - N°20180221381

Methods for treating tumors comprise contacting tumor cells expressing the vitamin d receptor with a vitamin d receptor ligand that inhibits homologous recombination in the tumor cells, and contacting the tumor cells with an amount of a poly(adp) ribose polymerase 1 (parp-1) inhibitor. Inhibiting homologous recombination produces a synergistic therapeutic effect between the vitamin d receptor ligand and parp-1 inhibitor, ...
Synthon formation
New England Biolabs, Inc.
August 02, 2018 - N°20180216098

This disclosure provides, among other things, a composition comprising: a 5′ exonuclease; a strand-displacing polymerase; and optionally a single strand dna binding protein and/or a ligase. A method for polynucleotide assembly to form a synthon, as well as a kit for performing the same, are also described..
System for continuous mutagenesis in vivo to facilitate directed evolution
The Regents Of The University Of California
August 02, 2018 - N°20180216097

A system for continuous mutagenesis to facilitate directed evolution, the system including dna polymerases carrying the novel k54e point mutation, and other point mutations including i709n, a759r, d424a (herein called k54e_lf pol i) and this methods of use to produce and detect lines where mutagenesis is continuous and does not exhibit the usual decline ...
Polymerase chain reaction device
Hewlett-packard Development Company, L.p.
August 02, 2018 - N°20180214866

Examples include polymerase chain reaction (pcr) devices. Example pcr devices comprise a fluid input, a fluid output, and a set of microfluidic channels that fluidly connect the fluid input and the fluid output.
Highly sensitive methods for detecting btk resistance mutations in rna and dna
Ohio State Innovation Foundation
July 26, 2018 - N°20180208993

Disclosed is a highly sensitive mutation-specific quantitative polymerase chain reaction (pcr) assay to detect btk mutations in b cells.. .
Genotyping by polymerase binding
Omniome, Inc.
July 26, 2018 - N°20180208980

A method for identifying target alleles, that includes steps of (a) forming a plurality of stabilized ternary complexes at a plurality of features on an array, wherein the stabilized ternary complexes each has a polymerase, a template nucleic acid having a target allele of a locus, a primer hybridized to the locus, and a next correct nucleotide having a cognate ...
Cloning of single-stranded nucleic acid
Max-planck-gesellschaft Zur FÖrderung Der Wissenschaften E.v.
July 26, 2018 - N°20180208966

The present invention relates to an oligonucleotide comprising (a) a double-stranded portion, which double-stranded portion is dna and 9 to 30 base in length; (b) a loop connecting the 3′ end of the first strand of said double-stranded portion with the 5′ end of the second strand of said double-stranded portion, said loop comprising, in 5′ to 3′ direction: (ba) a first ...
Polymerase Patent Pack
Download 270+ patent application PDFs
Polymerase Patent Applications
Download 270+ Polymerase-related PDFs
For professional research & prior art discovery
inventor
  • 270+ full patent PDF documents of Polymerase-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Methods and kits for the detection of powdery mildew
Bayer Sas
July 19, 2018 - N°20180202008

The present invention relates to means, methods and kits for the specific detection of the causing agent of powdery mildew on grapes, the fungus erysiphe necator. More specifically, the methods according to the invention are quantitative methods based on quantitative polymerase chain reaction..
Nanopore sequencing methods
Pacific Biosciences Of California, Inc.
July 19, 2018 - N°20180201993

Methods are provided for sequencing of nucleic acid templates using nanopores. A polymerase-nucleic acid complex having a strand displacing polymerase is provided.
Apparatus for high throughput chemical reactions
Takara Bio Usa, Inc.
July 19, 2018 - N°20180201978

Apparatus, systems, chips, and methods of performing a large number of simultaneous chemical reactions are provided herein. The chips of the invention comprise addressable units that can be addressed according to the temperature of the reaction to be run.
Method of producing rna from circular dna and corresponding template dna
Curevac Ag
July 19, 2018 - N°20180201967

The present invention is concerned with a method of producing a target rna using a circular dna, wherein said method does not comprise a step of linearizing said circular dna. The present invention further relates to a circular dna comprising an rna polymerase promoter sequence, followed by a sequence encoding a target rna, followed by a sequence encoding a self-cleaving ...
Production of polyhydroxyalkanoates with a defined composition from an unrelated carbon source
Wisconsin Alumni Research Foundation
July 19, 2018 - N°20180201961

Cells and methods for producing polyhydroxyalkanoates. The cells comprise one or more recombinant genes selected from an r-specific enoyl-coa hydratase gene, a pha polymerase gene, a thioesterase gene, and an acyl-coa-synthetase gene.
Massive parallel method for decoding dna and rna
The Trustees Of Columbia University In The City Of New York
July 19, 2018 - N°20180201642

This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of dna in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable ...
4'-fluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication
July 19, 2018 - N°20180200280

Produce a synergistic effect on the inhibition of hcv polymerase.. .
Sequencing method, apparatus, system and application thereof
Direct Genomics Co., Ltd.
July 12, 2018 - N°20180195117

A sequencing method comprising: (i) combining a template nucleic acid having a first optical detection label at the end with a primer to obtain a first complex; (ii) imaging the first complex to obtain a first image; (iii) mixing the first complex, polymerase, and one or more of nucleotides with a optical detection label to obtain an extension product by ...
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