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Nicotinamide

Nicotinamide-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Composition comprising ketone body and nicotinamide adenine dinucleotide modulator and methyl donor
September 13, 2018 - N°20180256612

The present invention provides a composition comprising a mixture of an exogenous ketone body, an exogenous nad modulator and a methyl donor. Typically, exogenous nad modulator is an exogenous nicotinamide adenine dinucleotide (nad) precursor.
Pyrazolo pyridine derivatives as nadph oxidase inhibitors
Genkyotex Suisse Sa
August 23, 2018 - N°20180235976

The present invention is related to pyrazolo pyridine derivatives of formula (i), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to nicotinamide adenine dinucleotide phosphate oxidase (nadph oxidase).. .
Compositions, methods and kits for treatment of diabetes and/or hyperlipidemia
Nusirt Sciences, Inc.
August 23, 2018 - N°20180235917

Compositions, methods and kits for treatment of diabetes and/or hyperlipidemia are provided herein. Such compositions can contain synergizing amounts of leucine and/or one or more leucine metabolites in combination with nicotinic acid, nicotinamide riboside and/or nicotinic acid metabolites, and with at least one or more anti-diabetic agents.
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Adiponectin secretion enhancer
Oriental Yeast Co., Ltd.
August 16, 2018 - N°20180228824

The present disclosure provides for the administration of β-nmn, which increases the secretion of adiponectin. The present disclosure also provides an adiponectin secretion enhancer comprising β-nicotinamide mononucleotide, a pharmaceutically acceptable salt thereof or a solvate thereof, and a dietary supplement containing the aforementioned secretion enhancer, which can he ingested in order to increase the secretion of ...
Amelioration of certain deficiencies due to stroke
Neuralstem, Inc.
August 16, 2018 - N°20180228787

Motor skill deficits and cognitive deficits associated with stroke and secondary neuronal cell death are ameliorated by treatment with pharmaceutically acceptable salts of 2-amino substituted nicotinamides.. .
Novel formulations and compositions for rejuvenation of the body
August 09, 2018 - N°20180221397

The present disclosure describes various formulations and compositions for improving one's vitality and health. The formulations may be particularly useful for treating or alleviating at least erectile dysfunction, increasing muscle mass, and encouraging saliva and tear production.
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Compositions, methods and kits for reducing lipid levels
Nusirt Sciences, Inc.
August 02, 2018 - N°20180214421

Compositions, methods, and kits useful for treating hyperlipidemic conditions are provided herein. Such compositions can contain synergizing amounts of nicotinic acid, nicotinamide riboside and/or nicotinic acid metabolites in combination with leucine and/or a leucine metabolite, with or without resveratrol..
Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
July 26, 2018 - N°20180208619

Wherein r1, r2, r3, and are as defined herein. Also disclosed are methods for increasing mammalian cell nad+ production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof..
Composition containing nad for preventing and treating obesity or impaired glucose tolerance
University Of Ulsan Foundation For Industry Cooperation
July 26, 2018 - N°20180207190

A pharmaceutical composition containing nicotinamide adenine dinucleotide (nad) as an active ingredient for preventing and treating obesity or impaired glucose tolerance, a food composition, and a method for preventing and treating obesity or impaired glucose tolerance using the same is disclosed. The nad remedies an abnormal food intake pattern of an obese animal model induced by the intake of a ...
Stable suspension concentrate formulation for water-soluble compounds
Fmc Corporation
July 26, 2018 - N°20180206496

The present invention is directed to an insecticidal water based suspension concentrate formulation comprising a water-soluble insecticide selected from the group consisting of n-cyanomethyl-4-(trifluoromethyl)nicotinamide and (ez)-1-(6-chloro-3-pyridylmethyl)-n-nitroimidazolidin-2-ylidineamine and at least one water-soluble salt selected from the group consisting of magnesium sulfate (hydrated and anhydrous forms) and sodium sulfate, wherein the water-soluble insecticide ...
Method and the use to improve oral absorption of nicotinamide and nicotinamide riboside
Better Standing Company Inc.
July 19, 2018 - N°20180200275

The present invention provides methods to improve oral absorption of nicotinamide or nicotinamide riboside or both nicotinamide and nicotinamide riboside via gastric (stomach) uptake or via intestinal uptake into the portal circulation blood. Mixtures of nicotinamide or nicotinamide riboside or both nicotinamide and nicotinamide riboside with botanical sources of flavonoids such as hibiscus sabdariffa dried calyces or cocoa powder or ...
Methods of preparing nicotinamide riboside and derivatives thereof
The Queen's University Of Belfast
July 05, 2018 - N°20180186824

The invention relates to methods of preparing nicotinamide riboside and derivatives thereof. In an aspect, the invention relates to a method of preparing a compound of formula (i), wherein n is 0 or 1; m is 0 or 1; y is o or s; r1 is selected from h, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted ...
6-(5-hydroxy-1h-pyrazol-1-yl)nicotinamide inhibitors of phd
July 05, 2018 - N°20180186772

Which are useful as inhibitors of phd, pharmaceutical compositions thereof, methods for treatment of conditions associated with hif, processes for making the compounds and intermediates thereof.. .
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Method for preparing nicotinamide mononucleotide (nmn)
Bontac Bio-engineering(shenzhen) Co.,ltd
June 14, 2018 - N°20180162895

The present invention provides a method for preparing nicotinamide mononucleotide (nmn) by biocatalysis. The method includes a step of catalytically reacting a plurality of raw materials including nicotinamide, atp, and ribose in the presence of nicotinamide phosphoribosyltransferase (nampt), ribose phosphate pyrophosphokinase, and ribokinase, to prepare the nmn..
Pharmaceutical compositions
Novartis Ag
June 07, 2018 - N°20180153899

Pharmaceutical compositions comprising the drug substance (r,e)-n-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1h-benzo[d]imidazol-2-yl)-2-methylisonicotinamide and processes to prepare these compositions.. .
Nicotinamide mononucleotide derivatives and their uses
May 31, 2018 - N°20180147227

The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives.
Use of nad precursors for breast enhancement
University Of Iowa Research Foundation
May 31, 2018 - N°20180147225

Certain embodiments of the invention provide a method for breast enhancement in a female mammal (e.g., a human) in need thereof, comprising administering an effective amount of a nicotinamide adenine dinucleotide (nad) precursor to the mammal.. .
Nicotinamide compositions and the therapeutic use thereof
Apet Holding B.v.
May 24, 2018 - N°20180140553

The present invention relates to compositions and methods for the prophylaxis or treatment of deficiencies in essential amino acid absorption and metabolism and/or of a pathology or symptom associated there with. In particular the invention concerns the treatment and/or prevention of adhd, add and autism spectrum disorders.
Tranilast compositions and cocrystals
Nuformix Limited
May 03, 2018 - N°20180118662

New tranilast complexes and new tranilast cocrystals are disclosed. These include a 1:1 tranilast nicotinamide complex, a 1:1 tranilast nicotinamide cocrystal, a 1:1 tranilast saccharin complex, a 1:1 tranilast saccharin cocrystal, a 1:1 tranilast gentisic acid complex, a 1:1 tranilast gentisic acid cocrystal, a 1:1 tranilast salicylic acid complex, a 1:1 tranilast salicylic acid cocrystal, a 1:1 tranilast urea complex, a 1:1 tranilast urea cocrystal, a 1:1 tranilast 4-aminobenzoic acid complex, ...
Amelioration of radiation-induced cognitive dysfunction
Neuralstem, Inc.
April 19, 2018 - N°20180104240

Treatment with 2-amino substituted nicotinamides ameliorates the cognitive dysfunction resulting from radiation of the brain.. .
Sensors, methods and kits for detecting nicotinamide adenine dinucleotides
Max-planck-gesellschaft Zur Förderung Der Wissenschaften E.v.
March 29, 2018 - N°20180087083

The invention relates to the in vitro and in cellulo detection of the cofactors nicotinamide adenine dinucleotide (nad) and nicotinamide adenine dinucleotide phosphate (nadp). Provided is a sensor molecule for fluorescence or luminescence-based detection of a nicotinamide adenine dinucleotide analyte, in particular for detecting the concentrations of nad+, nadp′ and/or the ratios of the concentrations of nad′/...
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