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Methylation

Methylation-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Composite biomarkers for non-invasive screening, diagnosis and prognosis of colorectal cancer
September 13, 2018 - N°20180258487

The present invention concerns particular biomarkers for diagnosing and/or prognosticating colorectal cancer, in particular in a non-invasive manner. The methods and compositions concern analysis of methylation patterns of one or more genes from a set of 29 genes identified as described herein.
Method of predicting the tumor response to dna methylation inhibitors and alternative therapeutic regimen for ...
Palacky University, Olomouc
September 06, 2018 - N°20180251847

Method for predicting sensitivity of a patient suffering from cancer to dna methylation inhibitor therapy uses in vitro in cancer cells taken from the patient. Cells are compared with parent type cells for expression of bromodomain containing genes, of other listed genes, and/or of bromodomain containing proteins.
Analysis of methylation using nucleic acid arrays
Affymetrix, Inc.
September 06, 2018 - N°20180251841

Arrays for genome-wide analysis of methylation are disclosed. In a preferred aspect arrays comprising a plurality of probes complementary to a plurality of identified cpg islands in the human, mouse and rat genome are disclosed.
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Methylation Patent Applications
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  • 124+ full patent PDF documents of Methylation-related inventions.
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Methylation biomarkers for breast cancer
King Abdullah University Of Science And Technology
August 23, 2018 - N°20180237867

Different combinations of methylation status based biomarkers can be used to test for breast cancer with high sensitivity and high specificity.. .
Mvd as epigenetic marker for the identification of immune cells, in particular cd56+ nk cells
Epiontis Gmbh
August 23, 2018 - N°20180237855

The present invention relates to a method, in particular an in vitro method, for identifying cd56+ nk cells, comprising analyzing the methylation status of at least one cpg position in the mammalian gene region for mevalonate (diphospho) decarboxylase (mvd), wherein a demethylation or lack of methylation of said gene region is indicative for a cd56+ nk cell, when compared to ...
Preparation of templates for methylation analysis
Massachusetts Institute Of Technology
August 23, 2018 - N°20180237844

The invention relates to a kit for preparing a library of template polynucleotides suitable for use as templates in solid-phase nucleic acid amplification and sequencing reactions to determine the methylation status of the cytosine bases in the library. In particular, the invention relates to a kit for preparing a library of template polynucleotides suitable for methylation analysis..
Methylation Patent Pack
Download 124+ patent application PDFs
Methylation Patent Applications
Download 124+ Methylation-related PDFs
For professional research & prior art discovery
inventor
  • 124+ full patent PDF documents of Methylation-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Unimolecular nanoparticles for efficient delivery of therapeutic cationic peptides
Wisconsin Alumni Research Foundation
August 23, 2018 - N°20180235897

Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to ryrprapiiavt (seq id no: 1). These cationic peptides inhibit pkm2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which pkm2 is overexpressed.
Cell-free methylated and unmethylated dna in diseases resulting from abnormalities in blood glucose levels
Universite Libre De Bruxelles
August 16, 2018 - N°20180230539

Disclosed herein are compositions and methods for determining new-onset type 1 diabetes, methylation-specific polymerase chain reaction assays for determining new-onset type 1 diabetes, methods for distinguishing between type 1 diabetes and type 2 diabetes, methods for dysglycemia in obese adolescent subjects including obese adolescent subjects having type 2 diabetes and methylation-specific polymerase chain reaction assays for determining dysglycemia in obese adolescent subjects including obese adolescent ...
Assays, methods and compositions for diagnosing cancer
Gopath Global, Llc
August 09, 2018 - N°20180223367

The present invention provides a method and single-tube assay for identification and quantitative analysis of differentially methylated mlh1 promoter sequences that are associated with certain types of cancer in an individual by obtaining a biological sample comprising dna from the individual, detecting the presence of and measuring the level of methylated mlh1 promoter sequences, and comparing the presence of and ...
Process and apparatus for the conversion of hydrocarbons
Exxonmobil Chemical Patents Inc.
August 09, 2018 - N°20180222819

A hydrocarbon conversion process is described. The process includes contacting in a reactor an inert gas with one or more catalyst compositions suitable for methylation of toluene and hydrogenation of phenol; contacting a reducing agent with the one or more catalyst compositions under conditions suitable for reducing metal oxide content of the catalyst composition; contacting at least part of toluene ...
Pd-l1 promoter methylation in cancer
Genentech, Inc.
August 02, 2018 - N°20180216196

This invention provides methods for the treatment of cancer in subjects having medium or low methylation level in the pd-l1 promoter region. Also provided are related kits and articles of manufacture..
Cancer detection methods
The United States Of America, As Represented By The Secretary, Department Of Health And Human
August 02, 2018 - N°20180216195

The present application provides methods for the detection and diagnosis of cancer. In one aspect, the application provides methods for detecting the presence of cancer in an individual by detecting the methylation state of a region in the promoter of the znf154 gene.
Lrp5 as epigenetic marker for the identification of immune cells, in particular b-cells
Epiontis Gmbh
August 02, 2018 - N°20180216185

The present invention relates to a method, in particular an in vitro method, for identifying b cells, comprising analyzing the methylation status of at least one cpg position in the mammalian gene region for low density lipoprotein receptor-related protein 5 (lrp5), wherein a demethylation or lack of methylation of said gene region is indicative for a b cell, when compared to ...
Methylation Patent Pack
Download 124+ patent application PDFs
Methylation Patent Applications
Download 124+ Methylation-related PDFs
For professional research & prior art discovery
inventor
  • 124+ full patent PDF documents of Methylation-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Integrated purification and measurement of dna methylation and co-measurement of mutations and/or mrna expression ...
Cepheid
August 02, 2018 - N°20180214864

Methods of determining methylation of dna are provided. In one illustrative, but non-limiting embodiment the method comprises i) contacting a biological sample comprising a nucleic acid to a first matrix material comprising a first column or filter where said matrix material binds and/or filters nucleic acids in said sample and thereby purifies the dna; ii) eluting the bound dna ...
Methods for determining fitness in plants
Bayer Cropscience Nv
July 26, 2018 - N°20180209000

Means and methods are provided to produce abiotic stress tolerant plants with improved yield based on the specific identification of a dna methylation signature in the plants out of a population of the plants. The methods involve identification and utilization of epigenetic features of a plant with high energy use efficiency.
Cpg island methylation profile in non-invasive oral rinse samples for detection of oral and pharyngeal ...
University Of Cincinnati
July 26, 2018 - N°20180208992

There are currently no screening tests in routine use for oral and pharyngeal cancer beyond visual inspection and palpation. Described is an improve method of detecting oral and pharyngeal cancer with a saliva sample from a subject.
System, method and kit for analysis of circulating differentially methylated dna as a biomarker of ...
Nyu Winthrop Hospital
July 26, 2018 - N°20180208985

β-cell loss in in type 1 diabetes is typically undetected until the development of hyperglycemia, at which point β-cell mass is significantly reduced. Methylation sensitive quantitative real time pcr (qrtpcr) of demethylated circulating free β-cell specific dna can be used as a biomarker of β-cell death.
Process for the synthesis of 9,9-bis(hydroxymethyl)fluorene
Sabic Global Technologies B.v.
July 26, 2018 - N°20180208530

The present invention relates to a novel process for the synthesis of 9,9-bis(hydroxymethyl)fluorene. The syntheses from fluorene to 9,9-bis(hydroxymethyl)fluorene via a hydroxymethylation and further to 9,9-bis(methoxymethyl)fluorene via a etherification are known.
Methods for detecting cpg methylation and for diagnosing cancer
Epigenomics Ag
July 19, 2018 - N°20180202006

The present invention relates to the field of pharmacogenomics and in particular to detecting the presence or absence of hypermethylated dna. The detection of cpg methylation in marker dna is useful for the diagnosis of cancers and the invention provides improved methods for this purpose.
Improved detection of methylated dna
Biocartis Nv
July 19, 2018 - N°20180201973

The present invention is based on the discovery of sensitive and specific methylation detection by a) controlling excessive dna degradation prior to conversion by incubating dna conversion reagent (e.g. Bisulfite reagent) directly with a nucleic acid containing sample without requiring prior nucleic acid purification from the sample and without requiring prior nucleic acid denaturation at elevated temperatures of 98° ...
Method for profiling protein methylation
University Of Ottawa
July 05, 2018 - N°20180188262

There is provided a method for identifying protein methylation on arginine and lysine residues. The method comprises obtaining a set of peptides; blocking un-methylated arginine and lysine residues and the free n-terminal amine of peptides in the set of peptides, so that un-methylated peptides are neutralized and only methylated peptides are positively charged at neutral or basic ph; isolating the ...
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