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Ligase

Ligase-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Ligase-assisted nucleic acid circularization and amplification
General Electric Company
August 09, 2018 - N°20180223349

Provided herein are methods for generation and amplification of a single-stranded dna circle in a single reaction vessel from a linear dna without any intervening purification steps. The single-stranded dna circle is generated via a template-independent single-stranded dna ligation.
Dna ligation on rna template
Affymetrix, Inc.
August 09, 2018 - N°20180223346

Disclosed are methods and compositions for detection and amplification of nucleic acids, wherein two dna strands hybridized to an rna strand are ligated. In one aspect, the disclosed methods include removal of an energy source, such as atp, upon charging a ligase to form an enzyme-amp intermediate, and then adding substrate, which results in one complete round of rna-templated dna ...
Park2 as epigenetic marker for the identification of immune cells, in particular monocytes
Epiontis Gmbh
August 02, 2018 - N°20180216184

The present invention relates to a method, in particular an in vitro method, for identifying monocytes, comprising analyzing the methylation status of at least one cpg position in the mammalian gene region for parkin rbr e3 ubiquitin protein ligase (park2), wherein a de-methylation or lack of methylation of said gene region is indicative for a monocyte, when compared to a ...
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Synthon formation
New England Biolabs, Inc.
August 02, 2018 - N°20180216098

This disclosure provides, among other things, a composition comprising: a 5′ exonuclease; a strand-displacing polymerase; and optionally a single strand dna binding protein and/or a ligase. A method for polynucleotide assembly to form a synthon, as well as a kit for performing the same, are also described..
Cereblon ligands and bifunctional compounds comprising the same
Arvinas, Inc.
August 02, 2018 - N°20180215731

The description relates to cereblon e3 ligase binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present disclosure. In particular, the description provides compounds, which contain on one end a ...
Egfr proteolysis targeting chimeric molecules and associated methods of use
Yale University
July 12, 2018 - N°20180193470

The present disclosure relates to bifunctional compounds, which find utility as modulators of receptor tyrosine kinase (rtk) proteins. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand which binds to an e3 ubiquitin ligase and on the other end a moiety which binds a target protein, such that the target protein is ...
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Proteolysis targeting chimera compounds and methods of preparing and using same
Yale University
July 05, 2018 - N°20180186785

The present invention includes novel compounds and methods for preventing or treating diseases associated with and/or caused by overexpression and/or uncontrolled activation of a tyrosine kinase in a subject in need thereof. In certain embodiments, the compounds of the present invention comprise a tyrosine kinase inhibitor, a linker and a ubiquitin ligase binder.
Protein having synthetic activity for imidazole dipeptid and production method of imidazole dipeptide
Tokai Bussan Co., Ltd.
June 28, 2018 - N°20180179511

The present invention provides l-amino acid α-ligase represented by sequence number 1 (seq id no. 1), which is a mutant protein including substitution of at least 1-3 amino acid residues of amino acid sequence of protein ywfe, with the substitution being at least one of an asparagine (n) residue of the 108th place from the n terminal being substituted with ...
Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides
Yale University
June 28, 2018 - N°20180179183

The present disclosure relates to bifunctional compounds, which find utility as modulators of rapidly accelerated fibrosarcoma (raf, such as c-raf, a-raf and/or b-raf; the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a von hippel-lindau, cereblon, inhibitors of apotosis proteins or mouse double-minute homolog 2 ligand which binds to the respective ...
Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
Arvinas, Inc.
June 28, 2018 - N°20180177750

The present disclosure relates to bifunctional compounds, which find utility as modulators of enhancer of zeste homolog 2 (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a von hippel-lindau, cereblon, inhibitors of apotosis proteins or mouse double-minute homolog 2 ligand which binds to the respective e3 ubiquitin ligase and on the other end ...
Methods of treating cancer
The University Of Rochester
June 21, 2018 - N°20180171288

Compositions and methods of treating a subject with cancer are described. The methods include administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a compound with the dual characteristics or restoring function of the c-cbl ubiquitin ligase in cancer cells and in also worsening sublethal lysosomal dysfunction, preferably in combination with an agent capable of making ...
Methods and compositions for enhanced biomass production and increased abiotic stress tolerance
North Carolina State University
June 21, 2018 - N°20180168120

This invention relates to methods for increasing carbon fixation, increasing biomass production and/or increasing abiotic stress tolerance in a plant comprising: introducing into a plant, plant part, and/or plant cell a heterologous polynucleotide encoding a ferredoxin polypeptide and/or a heterologous polynucleotide encoding a biotin ligase polypeptide to produce a stably transformed plant, plant part, and/or plant ...
Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders
Arvinas, Inc.
June 07, 2018 - N°20180155322

The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end at least one of a von hippel-lindau ligand, a cereblon ligand, inhibitors of apoptosis proteins ligand, mouse double-minute homolog 2 ligand, or a combination thereof, which binds to the ...
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Method for constructing a plasma dna sequencing library
May 24, 2018 - N°20180142235

The disclosure relates a method for constructing a plasma deoxyribonucleic acid (dna) sequencing library. The method includes: extracting a plasma dna; making the plasma dna ligate to a sequencing linker, and purifying a ligation product; performing polymerase chain reaction (pcr) amplification for the purified ligation product, purifying the pcr amplification product, and obtaining the plasma dna sequencing library, wherein, the ...
Ubiquitin ligase kpc1 promotes processing of p105 nf-kappab1 to p50, eliciting strong tumor suppression
Rappaport Family Institute For Research In The Medical Sciences
May 24, 2018 - N°20180140667

The invention provides a method for treating cancer comprising the step of administering a therapeutically effective amount of kpc1, a peptide which is at least about 70% homologous to the kpc1 or an agent which up-regulates kpc1. In some embodiments, there is also provided a method for treating cancer comprising the step of administering a therapeutically effective amount of p50, a ...
Parthenolide and its derivative for use in the treatment of axonal damage
Heinrich-heine UniversitÄt DÜsseldorf
May 24, 2018 - N°20180140574

The present invention relates to a compound reducing microtubule detyrosination in axonal tips selected from the group consisting of tubulin carboxypeptidase inhibitors and tubulin tyrosine ligase activators and combinations thereof for use in the treatment of axonal damage.. .
Tau-protein targeting protacs and associated methods of use
Arvinas, Inc.
May 10, 2018 - N°20180125821

The present disclosure relates to bifunctional compounds, which find utility as modulators of tau protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a vhl or cereblon ligand which binds to the e3 ubiquitin ligase and on the other end a moiety which binds tau protein, such that tau protein is placed in ...
Lap e3 ligase directed proteolysis targeting chimeric molecules
Glaxosmithkline Intellectual Property Development Limited
May 03, 2018 - N°20180118733

The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of rip2 kinase, including degrading rip2 kinase, the treatment of diseases and conditions mediated by the rip2 kinase, in particular for ...
Triazole benzamide derivatives and the compositions and methods of treatment regarding the same
An2h Discovery Limited
May 03, 2018 - N°20180118697

The present disclosure is directed to triazole benzamide compounds of formula (i) and formula (ii), pharmaceutical compositions thereof and methods for modulating or activating a parkin ligase the present disclosure is also directed to methods of treating and/or reducing the incidence of diseases or conditions related to the activation of parkin ligase. R1, r2, r3, m1, m2, m3, l1, ...
Modified ube3a gene for a gene therapy approach for angelman syndrome
University Of South Florida
April 19, 2018 - N°20180104358

Angelman syndrome (as) is a genetic disorder occurring in approximately one in every 15,000 births. It is characterized by severe mental retardation, seizures, difficulty speaking and ataxia.
Compounds and methods for the targeted degradation of androgen receptor
Arvinas, Inc.
April 12, 2018 - N°20180099940

The present disclosure relates to bifunctional compounds, which find utility to degrade and (inhibit) androgen receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the e3 ubiquitin ligase and on the other end a moiety which binds androgen receptor, such that androgen receptor is placed in proximity to ...
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