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Immune Response

Immune Response-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Pd-1 antibodies and uses thereof
October 04, 2018 - N°20180282412

The present invention provides monoclonal antibodies that specifically bind to human pd-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided.
Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease
October 04, 2018 - N°20180282401

The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of alzheimer's ...
Novel peptides and combination of peptides for use in immunotherapy against esophageal cancer and other ...
October 04, 2018 - N°20180282394

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer.
Immune Response Patent Pack
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Immune Response Patent Applications
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  • 464+ full patent PDF documents of Immune Response-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Hepatitis c virus e1/e2 heterodimers and methods of producing same
October 04, 2018 - N°20180282377

The present disclosure provides affinity tagged heterodimeric polypeptides comprising a hepatitis c virus (hcv) e1 polypeptide and an hcv e2 polypeptide, where one or both of the e1 and e2 polypeptides comprises an affinity tag. The present disclosure provides a method of producing an affinity tagged e1/e2 heterodimer of the present disclosure.
Naphthyridines as inhibitors of hpk1
October 04, 2018 - N°20180282328

Naphthyridine compounds and their use as inhibitors of hpk1 are described. The compounds are useful in treating hpk1-dependent disorders and enhancing an immune response.
Isoquinolines as inhibitors of hpk1
October 04, 2018 - N°20180282282

Isoquinoline compounds and their use as inhibitors of hpk1 (hematopoietic kinase 1) are described. The compounds are useful in treating hpk1-dependent disorders and enhancing an immune response.
Immune Response Patent Pack
Download 464+ patent application PDFs
Immune Response Patent Applications
Download 464+ Immune Response-related PDFs
For professional research & prior art discovery
inventor
  • 464+ full patent PDF documents of Immune Response-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Compounds and therapeutic uses thereof
October 04, 2018 - N°20180280521

The invention relates to novel compounds with the ability to link an immune response to a defined therapeutic target, to the use of said compounds in treating cancer and a disease or disorder mediated and/or caused by an infective agent, to compositions containing said compounds, processes for their preparation and to novel intermediates used in said process.. .
Methods and compositions for treating cancer using pd-1 axis antagonists and hpk1 antagonists
October 04, 2018 - N°20180280505

Compositions and methods for enhancing an immune response and treating cancer are provided. Compositions comprise pd-1 axis antagonists and hpk1 antagonists.
Aluminum based adjuvants for tolerogenic vaccination
October 04, 2018 - N°20180280498

The present invention provides methods of modulating an immunological disorder or an immune response. The methods include administering to a subject or a cell an effective amount of an autoimmune antigen and an anti-inflammatory cytokine included in an aluminum-based carrier.
Expression vector delivery system and use thereof for inducing an immune response
October 04, 2018 - N°20180280497

Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (...
Cholera toxin chimera and its use as a staph vaccine
October 04, 2018 - N°20180280492

The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of staphylococcus aureus. One embodiment of the present invention provides a method of generating an immune response in a mammal, that includes administering to the mammal, a composition having a chimeric protein having at least one of: a portion of a cholera toxin, a ...
Recombinant listeria vaccine strains and methods of using the same in cancer immunotherapy
October 04, 2018 - N°20180280487

The present invention provides methods of treating, protecting against, and inducing an immune response against a human papillomavirus-associated tumor or cancer, comprising the step of administering to a subject a recombinant listeria strain expressing a construct comprising at least one human papillomavirus antigen.. .
Nanoparticle based tumor endothelial targeting vaccine
October 04, 2018 - N°20180280444

Disclosed are methods, compositions of matter, and therapeutic protocols for treatment of cancer by selectively inducing immune responses against blood vessels feeding neoplastic tissue. In one embodiment, placental endothelial cells are stimulated with phorbol myristate acetate (pma) to induce release of nanoparticles that possess ability to: a) be taken up by antigen presenting; b) presented through direct and indirect presentation ...
Immune Response Patent Pack
Download 464+ patent application PDFs
Immune Response Patent Applications
Download 464+ Immune Response-related PDFs
For professional research & prior art discovery
inventor
  • 464+ full patent PDF documents of Immune Response-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Deimmunized therapeutic compositions and methods
Regents Of The University Of Minnesota
September 27, 2018 - N°20180273920

This disclosure provides a bispecific ligand directed toxin (blt) that includes a diphtheria toxin (dt) molecule that has been mutated to create a dt molecule that induces less of an immune response than native diphtheria toxin. The deimmunized dt molecule is fused with targeting ligands to create a fusion protein that can selectively deliver the deimmunized dt to target cells ...
Human immune therapies using a cd27 agonist in combination with another immune agonist to treat ...
University Of Southampton
September 27, 2018 - N°20180273631

Methods of inducing t cell proliferation and expansion in vivo for treating conditions wherein antigen-specific t cell immune response are therapeutically desirable such as cancer, infection, inflammation, allergy and autoimmunity and for enhancing the efficacy of vaccines are provided. These methods comprise the administration of at least one cd27 agonist, preferably an agonistic cd27 antibody, alone or in association with ...
Combination therapy for treatment of disease
Oncomed Pharmaceuticals, Inc.
September 27, 2018 - N°20180273618

The present invention provides methods comprising combination therapy for modulating immune responses, for inhibiting tumor growth, and/or for treating cancer. In particular, the present invention provides notch pathway inhibitors in combination with immunotherapeutic agents for the treatment of cancer and other diseases..
Multi-epitopic construct
Thrombosis Research Institute
September 27, 2018 - N°20180273608

The invention relates to multiple epitope constructs, immunogenic and vaccine compositions comprising recombinant molecules presenting inserted multiple and different epitopes from a variety of antigens. The antigenic determinants being associated with different pathways leading to atherosclerosis.
Methods of modulating immune responses using bcma polypeptide
Topotarget Switzerland Sa
September 27, 2018 - N°20180273605

A novel receptor in the tnf family is provided: baff-r. Chimeric molecules and antibodies to baff-r and methods of use thereof are also provided..
Immune cell compositions and methods of use
Memorial Sloan Kettering Cancer Center
September 27, 2018 - N°20180273601

Disclosed herein are cells that are immune cells or precursor cells thereof, which cells recombinantly express a chimeric antigen receptor (car), and a dominant negative form of an inhibitor of a cell-mediated immune response of the immune cell, wherein the car binds to a cancer antigen. Also disclosed herein are t cells that recognize and are sensitized to a cancer ...
Glycotargeting therapeutics
École Polytechnique Fédérale De Lausanne (epfl)
September 27, 2018 - N°20180271986

Several embodiments of the present disclosure relate to therapeutic compositions configured to target the liver of a subject and that are useful in the treatment or prevention of one or more of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to ...
Biomaterials for combined radiotherapy and immunotherapy of cancer
The Brigham And Women's Hospital, Inc.
September 27, 2018 - N°20180271978

Compositions and methods for the radiological and immunotherapeutic treatment of cancer are provided. Metallic nanoparticles conjugated with an immunoadjuvant are dispersed within a biodegradable polymer matrix that can be implanted in a patient and released gradually.
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