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Heart patents

      

This page is updated frequently with new Heart-related patent applications.

Method for interaction between terminal and network device, and terminal
Embodiments of the present invention provide a method for interaction between a terminal and a network device, including: sending, by a terminal, a first heartbeat to a network device; receiving, by the terminal, a first heartbeat response returned by the network device; if a screen of the terminal is in an off state, and optionally, the off state lasts for a preset period of time, releasing network link resources of a connection between the terminal and the network device, and/or prohibiting a background application of the terminal from accessing the network device, and/or disabling a data service of the terminal; before the terminal sends a second heartbeat to the network device, restoring, by the terminal, a status of network connection to a normal connection state; sending, by the terminal, the second heartbeat to the network device; and receiving, by the terminal, a second heartbeat response returned by the network device.. .

Wearable health monitors and methods of monitoring health
Wearable technologies, such as wearable health monitors, and methods of use are provided. In some embodiments, the wearable technology can be worn at the wrist of an individual and can use an accelerometer, pulse oximeter, and electrocardiogram to measure heart rate, oxygen saturation, blood pressure, pulse wave velocity, and activity.

Modified bacterial nanocellulose and its uses in chip cards and medicine
The present invention relates to bacterial nanocellulose composite which comprises nanocellulose, sensor or signal processing molecule(s), actuator/effector molecule(s) and/or cells and optionally further component(s). The present invention further relates to the use of the bacterial nanocellulose composite in chip technology and material engineering.

Apicidin-containing composition for inducing differentiation of mesenchymal stem cells into cardiac-committed cells
The present invention relates to an apicidin composition for inducing differentiation of mesenchymal stem cells into cardiac-committed cells, and a method for inducing differentiation into cardiac-committed cells using the same. The present invention allows mesenchymal stem cells to be specifically induced to differentiate into cardiac-committed cells even when an apicidin is treated for only a very short period of time of 24 hours, thereby being capable of solving the extremely low cardiomyogenic differentiation efficiency of mesenchymal stem cells, high cost, and long-term problems in the conventional art, and thus the present invention can be usefully used for treating heart disease..

Heterocyclic compounds useful in the treatment of disease
Heterocyclic compounds are described that are lysophosphatidic acid receptor ligands that are useful in the treatment of lysophosphatidic acid receptor-dependent diseases and conditions, including but not limited to diseases involving fibrosis, such as fibrosis of the heart, kidney, liver and lung, and scleroderma; inflammatory diseases such as diabetic nephropathy and nonalcoholic steatohepatitis (nash); ocular diseases such as diseases involving retinal degeneration; nerve diseases such as pruritus and pain.. .

Methods and power conversion and data transmission in implantable sensors, stimulators, and actuators
Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters.

Implantable cardiac resynchronizer with biventricular pacing and detection of loss of capture and anodal stimulation
A medical device for stimulating the heart using biventricular stimulation. The device includes a sensor for detecting an endocardial acceleration parameter and a processing circuit configured to receive the endocardial acceleration parameter.

Apparatus and the detection and treatment of atrial fibrillation
Embodiments of the invention provide methods for detection and treatment of atrial fibrillation (af) and related conditions. One embodiment provides a method comprising measuring electrical activity of the heart using electrodes arranged on the heart surface to define an area for detecting aberrant electrical activity (aea) and then using the measured electrical activity (mea) to detect foci of aea causing af.

Catheter-based heart support system and implanting thereof
A device for circulatory support of the heart with holding means implanted intracardially in the left or right ventricular outflow of the heart by catheter, using an endovascular method, through a femoral access or a percutaneous transventricular, transseptal, transapical or transvenous access, the holding means comprises anchoring means fixed in the subcommissural triangle underneath the aortic valve and the pulmonary valve, in the flow direction of the blood on the ventricular side of the aortic valve and the pulmonary valve, a pump fixed in the holding means by a catheter, using an endovascular method, through a femoral access or a percutaneous transventricular, transseptal, transapical or transvenous access, the pump can be inserted releasably into the holding means after the holding means has been fixed by the anchoring means in the subcommissural triangles underneath the aortic valve and the pulmonary valve, or is connected to the collapsible and expandable anchoring means.. .

Bag3 compositions and methods
The present invention features methods and compositions for treatment of heart failure. The compositions can include an isolated nucleic acid encoding a bag3 polypeptide or fragment thereof..

Methods for treating cardiac injury

Provided herein are methods for promoting differentiation of cardiac progenitor cells toward myocytes and suppressing the conversion of cardiac progenitor cells into fibroblasts and myofibroblasts cells in a subject determined to have cardiac progenitor cells in or around the heart, by administering a therapeutically effective amount of an nrg-1 peptide or functional variant or fragment thereof. The methods disclosed herein can be used to treat, prevent, or delay the progression of cardiac injury, for example heart failure or myocardial infarction..

Compositions for treating heart disease by inhibiting the action of makap-ß

The present invention provides a method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of rsk3 and makapβ, or the expression or activity of one or both of those molecules. This composition may be in the form of a peptide that specifically inhibits makapβ binding to rsk3 or in the form of an sirna construct which inhibits the expression of rsk3..

Modulating phosphatase activity in cardiac cells

Expression of a phosphatase inhibitor in heart cells can be used to treat cardiac disorders, e.g., heart failure. Decreasing phosphatase activity can improve β-adrenergic responsiveness..

Compositions and methods for increasing athletic performance

Compositions, methods, and uses are contemplated in which a betalain-containing preparation is administered to a mammal to enhance athletic performance. Most preferably, the preparations are substantially nitrate free and acutely and transiently increase hematocrit, erythropoietin, adrenalin, and beta endorphin, while reducing serum lactate, serum lactate dehydrogenase, heart rate and a rate of perceived exertion..

Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration

Methods of treating atrial arrhythmia include administering an effective amount of at least one antiarrhythmic pharmaceutical agent to a patient in need thereof, such that the at least one antiarrhythmic pharmaceutical agent first enters the heart through the pulmonary vein to the left atrium. Other methods of treating atrial arrhythmia include administering by inhalation an effective amount of at least one antiarrhythmic pharmaceutical agent to a patient in need thereof.

Self-adjusting tissue holder

Tissue holders that can be used for gripping natural or synthetic heart valves are described. The tissue holder can include a clamping mechanism and a spring and can be self-adjusting with regard to pressure applied to the tissue gripped in the holder.

Papillary muscle position control devices, systems, and methods

Papillary muscle position control devices, systems, and methods are provided. A papillary muscle position control device generally includes a first anchor, a second anchor, and a support structure.

Delivery systems with tethers for prosthetic heart valve devices and associated methods

Delivery systems with tethers for prosthetic heart valve devices and associated methods are disclosed herein. A delivery system configured in accordance with embodiments of the present technology can include, for example, an elongated catheter body, a capsule carried by the elongated catheter body and carrying a prosthetic heart valve device, and a cinching member slidably disposed within the capsule.

Devices, accurate positioning of a prosthetic valve

The invention is a system and method for accurately positioning a prosthetic valve such as a prosthetic heart valve at a desired position for deployment. The invention includes extendable positioning elements which provide tactile feedback to a user to confirm proper positioning of the catheter with respect to the native valve annulus.

Prosthetic valve for replacing a mitral valve

Embodiments of a prosthetic heart valve comprise an annular main body, an atrial cap extending radially outwardly from the atrial end of the main body, and a plurality of ventricular anchors extending outwardly from the ventricular end of the main body. Each ventricular anchor can have a proximal end portion connected to the ventricular end, an intermediate portion extending away from the atrial end and then back toward the atrial so as to define a first bend, and a free distal end portion that extends from the intermediate portion.

Prosthetic heart valve device and associated systems and methods

The present technology is a prosthetic heart valve device, and related systems and methods, for treating a native valve of a human heart having a native annulus and native leaflets. One embodiment comprises a valve support having an inflow region and an outflow region, and a prosthetic valve assembly within the valve support.

Heart valve sealing devices and delivery devices therefor

An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles have an outer portion and an inner portion.

Heart valve sealing devices and delivery devices therefor

An implantable prosthetic device has a coaption portion, paddles, and clasps. The paddles are extendable from a folded closed position to an open position.

Heart valve sealing devices and delivery devices therefor

An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles are extendable from a folded closed position to an open position.

Heart valve sealing devices and delivery devices therefor

An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles are extendable from a folded closed position to an open position.

Heart valve sealing devices and delivery devices therefor

An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles having an outer portion and inner portion.

Heart valve sealing devices and delivery devices therefor

An implantable prosthetic has a coaption portion, paddles, and clasps. The paddles are extendable from a folded closed position to an open position.

Heart valve sealing devices and delivery devices therefor

An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles are extendable from a folded closed position to an open position.

Heart valve sealing devices and delivery devices therefor

An implantable prosthetic device such as might be used to treat poor function of a diseased heart valve in a medical patient includes a body portion and an anchor portion including a plurality of paddles. Clasps attached to the paddles include fixed arms and moveable arms operable to secure the device to the patient's native valve leaflets..

Heart valve sealing devices and delivery devices therefor

An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles are extendable from a folded closed position to an open position.

Hydraulic systems for delivering prosthetic heart valve devices and associated methods

Systems for delivering prosthetic heart valve devices and associated methods are disclosed herein. A delivery system configured in accordance with embodiments of the present technology can include, for example, an elongated catheter body, a delivery capsule carried by the elongated catheter body, and two fluid chambers within the delivery capsule.

Rapid 3d cardiac parameter mapping

A method for generating a 3d map of a cardiac parameter in a region of a living heart, the method using single-plane fluoroscopic images and comprising: (a) placing a plurality of catheters each having one or more radio-opaque sensors into the region such that the locations of the sensors geometrically span the region; (b) capturing a first-view digitized 2d image of the region from a first fluoroscope positioned at a first angle; (c) identifying each of the plurality of sensors in the first-view image; (d) capturing a second-view digitized 2d image of the region from a second fluoroscope positioned at a second angle which is different from the first angle; (e) identifying each of the plurality of sensors in the second-view image; (f) associating each of the plurality of identified sensors in the second-view image with its corresponding identified sensor in the first-view image; (g) sensing and storing values of the cardiac parameter with each of the plurality of sensors; (h) determining the 3d location of each of the plurality of sensors from the first-view and second-view images using back-projection calculations; (i) associating each of the parameter values with its corresponding sensor location; (j) generating the parameter map from the first-view and second-view images; and (k) displaying the parameter map on a display device.. .

Medical image processing apparatus and x-ray ct apparatus

A medical image processing apparatus according to an embodiment includes processing circuitry. The processing circuitry sets a first region of interest in a region corresponding to cardiac muscle on a cross-section of a heart included in image data.

Altering physiological signals based on patient movement

This document describes ways in which to alter physiological signals to address corrupt, noisy, or otherwise faulty data. By so doing, accuracy and robustness in sensing and assessing a patient's cardiovascular health can be improved.

Parametric seizure detection

We report a method for detecting epileptic or non-epileptic seizures, comprising: receiving a heart rate of a patient; calculating a percentage change of the heart rate in reference to at least one of the patient's maximal heart rate, reserve heart rate, or a resting heart rate; detecting an epileptic seizure if the percentage increase in the heart rate reaches a threshold value; and taking at least one responsive action selected from issuing a warning, delivering a therapy, determining a seizure severity, or logging at least one of a date and time of occurrence of the seizure, its severity, the type of therapy, or its effect, in response to the detection. We also report a medical device system configured to implement the method.

System and fetal heartbeat sound monitoring and recording by propagation and spacial location analysis by a sensor matrix

A system for monitoring a fetal heartbeat sound has a sensor matrix adapted to be placed adjacent to a fetus, a processor for receiving signals transmitted by the sensor matrix, a processor for receiving signals transmitted by the sensor matrix, and a display connected to the processor so as to provide a humanly perceivable indication of the heartbeat sound. The sensor matrix has a plurality of sensors of which at least one of which is facing the fetus.

Catheter with multi-functional control handle having rotational mechanism

A catheter for use in a patient's heart, especially for mapping a tubular region of the heart, has a catheter body, a deflectable intermediate section and a distal mapping assembly that has a generally circular portion adapted to sit on or in a tubular region of the heart. A control handle of the catheter allows for single-handed manipulation of various control mechanisms that can deflect the intermediate section and contract the mapping assembly by means of a deflection control assembly and a rotational control assembly.

Method and device for determining and presenting surface charge and dipole densities on cardiac walls

The invention discloses a method, a system, a computer program and a device for determining the surface charge and/or dipole densities on heart walls. Using the foregoing, a table of dipole densities ν(p′, t) and/or a table of surface charge densities ρ(p′, t) of a given heart chamber can be generated..

Method for realizing panoramic display of exercise test using time axis

It relates to the field of displaying the heart-rate data collected in an exercise test, in particular to a method for achieving a panoramic display during electrocardiogram exercise test by using a time axis, comprising following steps: (a) building a horizontal axis (x axis) in units of time as a time axis, and building a vertical axis (y axis) in units of heart rate, therefore forming a two-dimensional tendency chart; (b) collecting and storing real-time 12-lead ecg raw data, acquiring and storing real-time heart rate data, (c) setting a time vernier, wherein in a default status, the time vernier is located at the current moment, and it is connected with 12-lead ecg raw data.. .

Detection of the heartbeat in cranial accelerometer data using independent component analysis

The invention relates to a computer-implemented medical data processing method for determining a heartbeat signal describing the heartbeat of a patient in the time domain, the method comprising executing, on a processor of a computer, steps of: a) acquiring, at the processor, acceleration measurement data describing an acceleration in the time domain of an anatomical body part measured on an external surface of the anatomical body part; b) determining, by the processor, component analysis data describing a result of an independent component analysis in the time domain of the acceleration measurement data; c) acquiring, at the processor, heartbeat template data describing template shapes of heartbeat in the time domain; d) determining, by the processor and based on the component analysis data and the heartbeat template data, recurrent shape data describing a recurrence of certain signal shapes in the component analysis data; e) determining, based on the recurrent shape data, heartbeat signal data describing a time series of the heartbeat.. .

Wearable physiological monitoring and notification system based on real-time heart rate variability analysis

Methods, devices, and systems for monitoring heart rate variability (hrv) are presented. The hrv monitoring systems and devices are adapted to give immediate feedback to the subject concerning their current condition and any pertinent changes in their condition.

Measurement system with voice recognition

A system includes a measurement apparatus having sensors measuring physiologic parameters such as blood pressure, heart rate, and/or blood oxygen level. A sensor is inserted into a user orifice and coupled to tissue comprising blood.

Legume/grain based food product with prebiotic/probiotic source

A minimally processed ready-to-eat legume/grain product is provided containing a significant amount of prebiotic fiber and a probiotic source or is consumed with a probiotic source for the prevention and/or treatment of inflammatory chronic conditions such as inflammatory, autoimmune chronic conditions such as irritable bowel syndrome (ibs), digestive disorders such chronic constipation, gastric acid reflux, diabetes, heart disease, obesity, some type of cancer, malabsorptive disorders, eczema as well mental health disorders such as anxiety disorder. The present invention is suitable for men and woman of all ages..

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Telematics 5g and multimode 4g and 3g mobile modulation format selectable (mfs) communications

Telematics, telemetry, including medical telemetry and telematics, one or multiple remote control (rc) or universal remote control (urc) devices, multimode 5g, 4g and 3g mobile modulation format selectable (mfs) communications wireless and wired communication networks, cellular systems and devices with fingerprint signal authentication. Touchscreen and motion detectors are controlling mobile devices.

Wearable cardioverter defibrillator (wcd) system computing patient heart rate by multiplying ecg signals from different channels

A wearable cardioverter defibrillator system includes a support structure that is configured to be worn by a patient. When thus worn, the support structure may attach electrodes at different locations of the patient's body, so as to define different vectors.

Detection of lead electrode dislodgement using cavitary electrogram

Methods and systems for identifying dislodgement of an electrode, operably coupled to an implanted medical device, from fixation with the endocardium of a chamber of the heart of a patient can include obtaining a test electrogram, and measuring at least two parameters indicating a cavitary electrogram and taking an action, such as generating an electrode dislodgement alert and/or configuring the implanted medical device to disable therapy, when the cavitary electrogram is indicated. In embodiments, the two parameters include a test positive component magnitude and a test negative component magnitude.

Cardiac stimulation system

Some embodiments of pacing systems employ wireless electrode assemblies to provide pacing therapy. The wireless electrode assemblies may wirelessly receive energy via an inductive coupling so as to provide electrical stimulation to the surrounding heart tissue.

Blood circulation system

Disclosed is an artificial heart and lung apparatus (100) that can be connected to a patient (p), and transfers removed blood to a human body via a roller pump (120), the system including: the roller pump (120); a blood removal line (101) which transfers removed blood to the roller pump (120); a first blood transfer line (104) that transfers blood, which is transferred from the roller pump (120), to the human body; a blood removal rate sensor (111) that is provided in the blood removal line (101); and a control unit (140), in which the control unit (140) performs control such that a blood transfer rate of the roller pump (120) is in a specific range with respect to a blood removal rate measured by a blood removal rate sensor (111).. .

Heart pump arrangement, and heart pump arrangement system

A heart pump arrangement including a heart pump and a control apparatus connected thereto, where the control apparatus has a first connector element of a first connection device, and including an intermediate plug-in module, which has a second connector element, which is detachably connectable to the first connector element, wherein the intermediate plug-in module has a second connection device, which is non-detachable or which is detachable within a framework of a second connection, for connection to an electrical power source, and additionally a third connection device, which is non-detachable or which is detachable within a framework of a third connection, for connection to a data processing device, in particular a terminal. By means of the connection possibilities of the intermediate plug-in module on the secondary side, incorrect connections to connected batteries, power supply units, or other apparatuses to be connected are minimised..

Methods and systems for an external drive unit for an implantable heart assist pump

The application relates to an external drive unit (7) for an implantable heart assist pump. The proposed drive unit (7) comprises a motor (35) for driving the heart assist pump, wherein the motor (35) is connectable to the heart assist pump via a transcutaneous drive shaft (3).

Method of treating lung, kidney, or heart disease with a recombinant ace2 polypeptide dimer

The present invention relates to recombinant ace2 polypeptide, where the ace2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for producing pharmaceutical products with an extended half-life.

Treatment of adipocytes

The present disclosure provides compositions comprising a lyn kinase activator and trpm8 agonist, and to methods of: reducing blood glucose levels, weight gain, or fat depot levels; treating metabolic syndrome, syndrome x, obesity, prediabetes, type ii diabetes, type i diabetes; treating hypercholesterolemia, hypertension, coronary heart disease, diabetic neuropathy, lipodystrophy, diabetic retinopathy, erectile dysfunction, kidney disease, dyslipidemia, dyslipoproteinemia, a peroxisome proliferator activated receptor-associated disorder, septicemia, a thrombotic disorder, or pancreatitis; inducing the beiging of adipocytes; and preventing pancreatic beta cell degeneration.. .

Enalapril formulations

Provided herein are stable enalapril oral liquid formulations. Also provided herein are methods of using enalapril oral liquid formulations for the treatment of certain diseases including hypertension, heart failure and asymptomatic left ventricular dysfunction..

Positioning, deploying, and retrieving implantable devices

Described herein are implant delivery systems and methods for controllably deploying an expandable device in a ventricle, the left atrial appendage, or other portion of the heart of a patient. In some embodiments, the implant delivery system includes means for loosening or releasing a suture on a perimeter region of the expandable device in order to control the expansion or contraction of the expandable member.

Ringless web for repair of heart valves

A ringless web is configured to repair heart valve function in patients suffering from degenerative mitral valve regurgitation (dmr) or functional mitral valve regurgitation (fmr). In accordance with various embodiments, a ringless web can be anchored at one or more locations below the valve plane in the ventricle, such as at a papillary muscle, and one or more locations above the valve plane, such as in the valve annulus.

Coronary sinus mitral valve annuloplasty procedure and coronary artery and myocardial protection device

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation.

Distal anchor mitral valve repair

Described herein are devices and methods for mitral valve repair. The devices and methods implant a plurality of distal anchors at an annulus of the mitral valve (e.g., the posterior annulus) and tension artificial chordae to pull the portion of the annulus toward an opposite edge and inward into the ventricle.

Delivery system with anchoring nosecone and delivery

A delivery device includes an inner shaft, an outer sheath, a nosecone, and a tether component. The outer sheath is slidably disposed over the inner shaft.

Prosthetic valve holders with automatic deploying mechanisms

A valve holder for delivering a prosthetic heart valve to an implant site is in various embodiments configured to reduce or eliminate the occurrence of suture looping or other damage to the prosthetic valve during implantation. The valve holder can be configured to deploy or actuate automatically when performing preparatory steps that are already familiar to practitioners, such as attaching a delivery handle to the valve holder, so that the valve holders will not require additional steps or training to use.

One-piece heart valve stents adapted for post-implant expansion

A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander..

Transcatheter atrial sealing skirt, anchor, and tether and methods of implantation

A medical assembly implanting an atrial sealing skirt in the heart at an atrial sealing skirt deployment site and related methods of implantation and delivery. An anchor is endovascularly introduced into the heart and implanted to a cardiac wall with an anchor delivery system and delivery cable.

Transcatheter atrial sealing skirt, anchor, and tether and methods of implantation

A medical assembly and methods for endovascularly implanting a valve in the heart having a valve and an anchor assembly for positioning and restraining the valve. An anchor delivery system introduces and implants the anchor into the implantation site and a valve delivery system introduces and seals the valve at the deployment site.

Percutaneously-deployable prosthetic tricuspid valve

Devices and methods for the treatment of heart conditions are provided herein. For example, this document provides devices and methods for treating tricuspid valve regurgitation by percutaneously implanting a prosthetic tricuspid valve..

Device and method with reduced pacemaker rate in heart valve replacement

The disclosure relates to heart valve prostheses with the reduced need of pacemaker implantation and improved means for positioning the replacement heart valve.. .

System and enhanced data analysis with specialized video enabled software tools for medical environments

Medical software tools platforms utilize a surgical display to provide access to specific medical software tools, such as medically-oriented applications or widgets, that can assist surgeons or surgical team in performing various procedures. In particular, an endoscopic camera may register the momentary rise in the optical signature reflected from a tissue surface and in turn transmit it to a medical image processing system which can also receive patient heart rate data and display relevant anomalies.

Impactor for fracturing calcifications in heart valves

A device for fracturing calcifications in heart valves includes a tube formed with at least two longitudinal slits that form at least two struts (4). Each of the struts includes two or more pairs of notches (3) formed on opposite sides of the strut.

Sensor system, sensor information processing apparatus, non-transitory computer-readable recording medium having stored therein sensor information processing program, and bed

A sensor system includes a transmitter configured to transmit radio wave and a detector configured to detect a body motion when a change in amplitude of a received wave of a transmitted radio wave is detected and a lack of a frequency component indicating one or both of a heartbeat and a respiration in a frequency analysis result of the received wave is detected.. .

Device to detect and treat apneas and hypopnea

A method and apparatus for the treatment of sleep apnea events and hypopnea episodes wherein one embodiment comprises a wearable, belt like apparatus containing a microphone and a plethysmograph. The microphone and plethysmograph generate signals that are representative of physiological aspects of respiration, and the signals are transferred to an imbedded computer.

Determining breathing attributes by a detection device

A method, apparatus and computer program product are provided for determining stress recovery based on chest and abdominal breathing information from a detection device such as a radar detection device. Stress recovery may be determined by monitoring a phase difference between chest and abdominal breathing relative to a stress indicator, such as heart rate variability.

Methods and systems for providing a breathing rate calibrated to a resonance breathing frequency

A target respiration rate is determined for a user where, when the user breathes at the target rate, the user's vagal tone is improved, which provides a physiological benefit to the user, e.g., stress reduction without drug intervention. The user is directed to breathe at different rates while heart rate and breathing rate are measured.

Cardiac catheter inspection apparatus, cardiac catheter inspection system, and cardiac catheter inspection method

A cardiac catheter inspection apparatus comprising: an acquiring section (31) which is configured to acquire a first waveform of heart beats during sinus rhythm, and an arrhythmia waveform during arrhythmia; a measuring section (31) which is configured to measure a second electrocardiogram; a first calculating section (32) which is configured to calculate correction coefficients for statistically matching the first electrocardiogram and the second electrocardiogram with each other; a waveform producing section (34) which is configured to produce a comparison waveform that functions as an object to be compared with a response waveform of pacing performed by a cardiac catheter; and a second calculating section (36) which is configured to calculate a matching rate of the response waveform and the comparison waveform.. .

System and blood pressure measurement

A system for use in monitoring blood circulation data of a user is disclosed. The system comprising a monitoring unit comprising at least one light source unit configured for providing and directing coherent illumination onto at least one selected inspection region on the user's body, and a collection unit configured for collecting light returning for at least a portion of the inspection region and generating a plurality of image data pieces associated with secondary speckle patterns in the collected light returning from said regions; and a control unit configured and operable for receiving said plurality of image data pieces, determining correlation functions between speckle patterns in consecutive image data pieces, processing said correlation functions for determining data indicative of at least two heart rate data sequence indicative of heart rate of the user, and determining data indicative of circulation pressure of the user in accordance with said data indicative of heart rate of the user measured at said first and second monitoring regions..

Petunia plant named 'damorfiest'

A new and distinct petunia cultivar named ‘damorfiest’ is disclosed, characterized by a mounded growth habit and flowers uniquely colored burgundy with yellow stripes. The plants are very well branched with a medium vigor.

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Passport-controlled firewall

A method and system for dynamically modifying rules in a firewall infrastructure. A signed passport, which includes a heart-beat time-out interval and a firewall rule, is received.

Wireless monitoring system

A wireless monitoring system for monitoring at least one person in a building. The wireless monitoring system comprises a data collection device and a plurality of wireless signalling devices working in a star network topology, the data collection device being adapted to wirelessly receive data transmitted from each of the plurality of wireless signalling devices.

Detection of reduced-control cardiac zones

A method of treating cardiac arrhythmia in a heart, including (i) determining that cardiac tissue is viable but with reduced innervation; and (ii) ablating the tissue to reduce a prevalence of arrhythmia in said heart. Optionally, the determining comprises detecting portions of heart wall which lack electrical activity.

Implantable medical device with a tethered transmit coil for transmitting power to another implantable medical device

A system for sensing electrical cardiac activity and for providing therapy to a patient's heart. The system may include a first implantable device implanted within a patient and a second implantable device implanted near or within the heart of the patient.

Temporary electrode connection for wireless pacing systems

Delivery of an implantable wireless receiver-stimulator (r-s) into the heart using delivery catheter is described. R-s comprises a cathode and an anode and wirelessly receives and converts energy, such as acoustic ultrasound energy, to electrical energy to stimulate the heart.

Cardiac pacemaker with pacing pulse energy adjustment based on sensed heart rate

Implantable medical devices (imd) such as a cardiac pacemakers may include a sensor and electrodes. In some cases, the imd may include electronics to use the sensor to determine the heart rate of a patient's heart.

System for treating brugada syndrome

Brugada syndrome and related forms of ion channelopathies, including ventricular asynchrony of contraction, originate in the region near the his bundle or para-hisian regions of the heart. Manifestations of brugada syndrome can be corrected by delivering endocardial electrical stimulation coincident to the activation wave front propagated from the atrioventricular (av) nodeearly enough to compensate for the conduction problems that start in those region.

Cardiac device for treating brugada syndrome

Brugada syndrome and related forms of ion channelopathies, including ventricular asynchrony of contraction, originate in the region near the his bundle or para-hisian regions of the heart. Manifestations of brugada syndrome can be corrected by delivering endocardial electrical stimulation coincident to the activation wave front propagated from the atrioventricular (av) node.

Tissue conduction velocity

A method includes acquiring a bipolar signal from a first electrode and a second electrode contacting a first location and a second location, respectively, in a heart of a living subject. The method further includes acquiring a unipolar signal from the first electrode while in contact with the first location, and deriving from the bipolar signal and the unipolar signal a point in time at which the first location is generating the unipolar signal.

Antegrade hemodynamic support

The procedure to place antegrade hemodynamic support (ahs) combine currently available procedures and devices in a unique fashion to solve a significant problem for patients who need large bore hemodynamic support. The ahs procedure involves delivering an ahs device or a catheter connected to an ahs device to a patient's aorta in an antegrade fashion, alleviating the workload on the patient's heart and supporting the patient hemodynamically to maintain normal functions of the body organs..

Heart vent catheter and use

A heart vent catheter includes an elongate, flexible tube that defines a first passageway. The catheter has a distal end, a central portion, and a proximal end.

Pressure sensing ventricular assist devices and methods of use

The invention generally relates to heart pump systems. In some embodiments, a pressure sensor is provided with a heart pump, either at the inflow or the outflow of the blood pump.

Adjusting pump protocol based on irregular heart rhythm

The present invention generally relates to heart treatment systems. In some aspects, methods and systems are provided for facilitating communication between implanted devices.

Communication methods and architecture for heart treatment systems

The present invention generally relates to heart treatment systems. In some aspects, methods and systems are provided for facilitating communication between implanted devices.

Thermistor imbedded therapeutic catheter

A system and method for determining native cardiac output of a heart while maintaining operation of an intracardiac blood pump includes determining a current drawn by the pump motor, a blood pressure within the ascending aorta, and a change in the blood temperature based on a thermodilution technique. An intracardiac blood pump positioned in the aorta includes at least one sensor for determining a motor current and blood pressure and a thermistor for determining the change in blood temperature after a precise fluid bolus has been introduced into the vasculature.

Methods for inhibiting stenosis, obstruction, or calcification of a stented heart valve or bioprosthesis

Methods for inhibiting stenosis, obstruction and/or calcification of a heart valve following implantation in a vessel having a wall are disclosed. In one aspect the method includes providing a bioprosthetic heart valve mounted on an elastical stent; treating the bioprosthetic heart valve with a tissue fixative; coating the stent and the bioprosthetic valve with a coating composition including one or more therapeutic agents; implanting the bioprosthetic valve into the vessel in a diseased natural valve site; eluting the coating composition from the bioprosthetic valve; and inhibiting stenosis, obstruction and/or calcification of the bioprosthetic heart valve by preventing the attachment of stem cells to the bioprosthetic heart valve, the stem cells circulating external and proximate to the bioprosthetic heart valve by activating nitric oxide production (i) in the circulating stem cells, (ii) in an endothelial cell lining covering the bioprosthetic heart valve tissue, (iii) or both..

Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure

The invention relates to treatment of heart failure in a mammal. Accordingly, the invention is directed to establishing a dosing regimen whereby the therapeutic benefits conferred by administration of a neuregulin such as glial growth factor 2 (ggf2) or a subsequence thereof are maintained and/or enhanced, while concomitantly minimizing any potential side effects..

Short acting phenylalkylamine calcium channel blockers and uses thereof

The present invention relates to the use of a pharmaceutically effective amount of an short-acting calcium channel blocking compound to treat ischemic heart conditions, cardiac arrhythmias, hypertensive crisis in an emergency room setting, hypertension before, during, or after surgery, no-reflow phenomenon following reperfusion, and diseases associated with decreased skeletal muscle blood flow. The invention also relates to pharmaceutical compositions formulated for use in such methods and to kits for such methods..

Minimally invasive heart valve repair in a beating heart

In one embodiment, a method of repairing a heart valve accesses an interior of a patient's beating heart minimally invasively and inserts one or more sutures into each of a plurality of heart valve leaflets with a suturing instrument. The suture ends of the sutures are divided into suture pairs, with each pair including one suture end from a suture inserted into a first valve leaflet and one suture end from a suture inserted into a second valve leaflet.

Expandable sheath for introducing an endovascular delivery device into a body

Embodiments of an expandable sheath can be used in conjunction with a catheter assembly to introduce a prosthetic device, such as a heart valve, into a patient. Such embodiments can minimize trauma to the vessel by allowing for temporary expansion of a portion of the introducer sheath to accommodate the delivery apparatus, followed by a return to the original diameter once the prosthetic device passes through.

Ambulatory blood pressure and vital sign monitoring apparatus, system and method

Representative methods, apparatus and systems are disclosed for determining one or more physiological parameters, such as for ambulatory blood pressure and other vital sign monitoring. A representative system comprises first and second wearable apparatuses to be worn on the user's left and right sides, and any of several types of central vital signs monitors.

Multi-channel ballistocardiography with cepstrum smoothing and quality-based dynamic channel selection

A method for ballistocardiography (bcg) and a bcg system ballistocardiography (bcg) system for heart beat determination are provided. The method includes digitizing a plurality of signals received from a corresponding plurality of sensors, estimating a plurality of smoothed cepstra corresponding to each of the plurality of digitized signals in response to a smoothed cepstrum analysis of a digital signal at a reception time of each of the plurality of digitized signals, and estimating a fused cepstrum for the plurality of digitized signals in response to the plurality of smoothed cepstra.

System and heart rate detection with motion artifact reduction

Example embodiments relate to systems and methods for heart rate detection with motion artifact reduction. One embodiment includes an electronic system for heart rate detection.

Detecting conditions using heart rate sensors

This relates to methods for measuring irregularities in a signal and corresponding devices. The devices can include a ppg sensor unit configured to detect multiple occurrences of a given event in the measured signal(s) over a sampling interval.

Systems and methods for internal ecg acquisition

A system for obtaining signals related to electrical activity of the heart of a subject includes a sensing device including an elongate member having a distal end configured for placement within a body lumen of a subject, and a proximal end configured to extend from the subject, an actuation portion carried by the elongate member and configured for placement within the body lumen, the actuation portion having a low-profile state for delivery within the body lumen and an expanded state, and one or more sensors disposed on the actuation portion, each including a contact surface configured to contact an interior wall of the body lumen, wherein the actuation portion is configured to cause the contact surface of each of the one or more sensors to contact a location on the interior wall of the body lumen to provide a signal component for producing one or more electrocardiogram signals.. .

Method to project a two dimensional image/photo onto a 3d reconstruction, such as an epicardial view of heart

A three-dimensional (3d) electrical mapping system and method may be used to generate a 3d image of the epicardial surface of a heart by integrating one or more epicardial images with a 3d image of the cardiac structure that may be generated by real-time 3d location and mapping system for cardiac mapping and ablation. The visual textural representation of the epicardial surface of the heart may be reconstructed using, for example, an image sensor or camera-based catheter to collect images of the epicardial surface.

Method and system for detecting frequency domain cardiac information by using pupillary response

Provided are a method and system for detecting frequency-domain cardiac information, the method comprising: acquiring moving images of a pupil from a subject; extracting a pupil size variation (psv) from the moving images; extracting a heart rate variability (hrv) spectrum by performing a processing procedure including frequency-analysis of hrv; and calculating power of at least one of a plurality of frequency bands by analysis of the hrv spectrum.. .

Dickerson medical meter

The dickerson medical meter assist diabetic people which manage their insulin levels and tells them the amount of insulin intake that they need at the time. The device uses a fingerprint sensor to read insulin levels and provides instructions if steps are needed to control blood sugar immediately.

Method and estimating the aortic pulse transit time from time intervals measured between fiducial points of the ballistocardiogram

A method and apparatus is proposed to estimate the aortic pulse transit time (ptt) from only time intervals measured between fiducial points of the longitudinal balistocardiogram (bcg) without the need to apply any sensor to the area where the arrival of the arterial pulse waveform is to be detected. From the longitudinal bcg of a subject, which can be obtained by means of sensors integrated in a single element with which the subject's body comes into contact, two fiducial points of the bcg waveform are detected in which one of the points is associated with the arrival of the arterial pulse wave to a zone proximal to the heart and the other is associated with the arrival of said arterial pulse wave to a distal zone, respectively.

System and cuffless blood pressure estimation

Disclosed is a system for estimating arterial blood pressure. The system includes a heartbeat detection module configured to receive an electrocardiogram signal, and detect one or more qrs complexes of the electrocardiogram signal.

Modular cardiac rhythm management using q to lv activation measures

Methods and systems for use of the q-wave to r-wave interval to guide placement of a leadless cardiac pacemaker are disclosed. An implant delivery device is equipped with sensing electrodes to sense r-wave onset in a ventricle of a patient's heart to allow placement at a location of last or latest onset of the r-wave.

Methods and physiological measurement using color band photoplethysmographic sensor

In illustrative implementations of this invention, a photoplethysmographic device measures variations of light that is reflected from, or transmitted through, human skin. In some implementations, the device includes a camera that takes the measurements remotely.

Device and measuring a vital signal

The present disclosure provides a vital sign measuring device and method that may measure a heart rate signal of a living body in a motion state. The method comprises detecting two different signals, using an adaptive noise removal algorithm for removing noise from the two signals, and obtaining a more accurate heat rate signal after a certain operation..

Device, obtaining vital sign information of a subject

The present invention relates to device, system and method for obtaining vital sign information of a subject (14). To enable reliably obtaining vital sign information of a subject, in particular of the subject's heart rate, the proposed device comprises an input unit (21) for obtaining a set of image data (31) detected from a skin portion (24) of the subject (14) allowing the extraction of the subject's heart rate (51) and a set of detection data (31, 41) detected from a body portion of the subject (14) allowing the extraction of the subject's respiration rate (53) or representing the subject's respiration rate (53), a heart rate extraction unit (22) for extracting the subject's heart rate from said set of image data (31) by use of photoplethysmography, a prediction unit (23) for predicting changes of the subject's heart rate based on the subject's respiration rate extracted from or represented by said set of detection data, and a control unit (24) for controlling one or more settings of said heart rate extraction unit (22) based on the predicted changes of the subject's heart rate..

Multi-person vital signs monitoring using millimeter wave (mm-wave) signals

A mm-wave system includes transmission of a millimeter wave (mm-wave) signal by a plurality of transmitters to multiple objects, and receiving of return-mm-wave signals from the multiple objects by a plurality of receivers. A processor is configured to perform an algorithm to derive complex-valued samples and angle measurements from each receiver to identify one object from another object.

Celery variety '51-7 ips 1'

A celery cultivar, designated 51-7 ips 1, is disclosed, the cultivar is, for larger frame size and heavier weight, short core length, savoyed and glossy leaf color, corky root rot resistance, no fringe burn on mature leaves and also yellower heart leaf color with solid midribs. The invention relates to the seeds of celery cultivar 51-7 ips 1, to the plants of celery cultivar 51-7 ips land to methods for producing a celery plant by crossing the cultivar 51-7 ips 1 with itself or another celery cultivar.

Voice track editor

Local stations can generate their station broadcast logs based on a master broadcast log. In some cases, local stations are allowed to edit some positions, or slots, in their local logs, so that the local logs do not match the master log.
Iheartmedia Management Services, Inc.

Automated traffic data validation

A first traffic-flow prediction associated with a roadway segment and a particular time is obtained by a verification module. The first traffic-flow prediction generated as an output of a prediction module implemented using a processor and associated memory, the prediction module operating on input including first traffic-related information obtained from a first plurality of traffic probe devices.
Iheartmedia Management Services, Inc.

Detection of blood vessels

A system for the detection of blood vessels includes an image sensor coupled to generate video data including a sequence of images of the blood vessels, and a heart rate monitor to measure a heart rate of a patient and to generate heart rate data. A controller is coupled to the image sensor to receive the video data, and coupled to the heart rate monitor to receive the heart rate data.
Verily Life Sciences Llc

Authentication system for controlling access and use based on heartbeat shape

Authentication system for enabling access or use includes a housing, a database of fingerprint and heartbeat data, a fingerprint sensor having a surface on an exterior of the housing onto which a person places their finger, and a heartbeat monitor that obtains data about presence of any heartbeat from a person whose fingers are placed onto the surface of the fingerprint sensor. A processor coupled to the fingerprint sensor, heartbeat monitor and database operatively compares the obtained fingerprint and heartbeat shape derived from heartbeat data to corresponding fingerprint and heartbeat shape data to determine whether the fingerprint and heartbeat shape data are indicative of a person authorized for access or use.
Intelligent Technologies International, Inc.

Methods and systems of database cluster formation and management

A computerized method useful for node cluster formation and management in a distributed database system includes the step of providing a set of database nodes in a database cluster. Each node of the set of database nodes comprises a cluster management module, a heartbeat module, and a globally unique node identifier.

Intelligent synch mode for defibrillation

The defibrillator may include a heart rhythm detector to detect the heart rhythm of a patient, a manual mode controller structured to set the defibrillator in a synchronous shock operating mode or an asynchronous shock operating mode depending on an input from a human operator, a shock module to cause the defibrillator to deliver a shock to the patient according to the operating mode, and an automatic mode controller structured to, after the shock module has delivered the shock to the patient, set the external defibrillator to the synchronous shock operating mode or the asynchronous shock operating mode depending on the detected heart rhythm of the patient and without input from the human operator.. .
Physio-control, Inc.

Use of the insulin-like-growth factor 1 splice variant mgf for the prevention of myocardial damage

The invention relates to the use of a mechano growth factor (mgf) polypeptide or a polynucleotide encoding an mgf polypeptide in the manufacture of a medicament for the prevention or limitation of myocardial damage in response to ischemia or mechanical overload of the heart by preventing or limiting apoptosis in the myocardium.. .
The Board Of Trustees Of The University Of Illinois

P75ntr antagonists and treatment of acute and chronic cardiac disease

The present invention provides 75 kd transmembrane neurotrophin receptor (p75ntr) antagonists and their use in prevention and treatment of loss of function, and adverse remodeling, in cardiac tissues subject to acute or chronic hemodynamic stress. Uses of the antagonists with or without additional cardiotropic agents for improving contractility and for treatment of congestive heart failure are also provided..
The Johns Hopkins University

Microporous zirconium silicate and diuretics for the reduction of potassium and treatment of chronic kidney and/or chronic heart disease

The present invention relates to novel methods of using microporous zirconium silicate to reduce the risk of hyperkalemia and to lower aldosterone levels in the treatment of chronic kidney disease and/or chronic heart disease with therapies comprising diuretics. The invention provides a safe way to reduce the risk of hyperkalemia and to lower aldosterone.
Zs Pharma, Inc.

Compositions and methods of using tyrosine kinase inhibitors

The present invention provides compositions and methods of inhibiting tyrosine phosphorylation. In one aspect, a composition comprising a low-dosage tyrosine kinase inhibitor, where the low-dosage tyrosine kinase inhibitor decreases tyrosine phosphorylation, is provided.
Yale University

Methods of treating heart failure

Pharmaceutical preparations and methods for treating or preventing a heart failure disease, including heart failure with preserved ejection fraction (hfpef), with one or more dialkyl fumarates alone or in combination with one or more second agents are provided herein. In some embodiments, the pharmaceutical preparations are in the form of micro-tablets or pellets..

Atrial pocket closures for prosthetic heart valves

A prosthetic heart valve can include an outer frame coupled to an inner frame such that the outer frame can be moved between a first position and a second position in which the outer frame is inverted relative to the inner frame. The inner frame and the outer frame define between them an annular space, and a pocket closure can bound the annular space to form a pocket in which thrombus can form and be retained.
Tendyne Holdings, Inc.

Apparatus and methods for implanting a replacement heart valve

Systems and methods for docking a heart valve prosthesis. A system can include an anchor formed as multiple coils adapted to support a heart valve prosthesis with coil portions positioned above and below the heart valve annulus.
Mitral Valve Technologies Sarl

Frame features for prosthetic mitral valves

Prosthetic heart valves are described herein that can provide clearance to the left ventricle outflow tract (lvot), reduce the possibility of undesirable outflow gradients, and/or limit or prevent lvot obstructions when implanted in the heart. In some embodiments, a prosthetic heart valve can include an outer frame having a cuff portion that is disposed at an angle (e.g., 80 degrees) relative to the vertical axis of a body portion of the outer frame, so that the prosthetic valve can seat securely in the annulus while not obstructing the ventricular outflow tract of the heart.
Tendyne Holdings, Inc.

Systems for replacing a native heart valve and aorta with a prosthetic heart valve and conduit

A medical device includes an expandable conduit, a prosthetic heart valve and a delivery device, including a balloon catheter. The expandable conduit may include one or more inner or outer sleeves supported by a frame or stent.
Edwards Lifesciences Corporation

Methods of implanting prosthetic heart valve using position markers

An exemplary two-stage prosthetic heart valve system has a radially expandable base stent implanted within a native valve annulus. The base stent desirably has three position markers projecting in the axial direction from the outflow end of the base stent to assist in aligning the stent with respect to the commissures of the native valve.
Edwards Lifesciences Corporation

Method for ablating body tissue

A cardiac ablation method including the following steps: inserting a treatment catheter into an atrium of a heart, the treatment catheter including an ultrasound emitter; positioning the ultrasound emitter to face heart tissue within the left atrium outside of a pulmonary vein; emitting ultrasound energy from the ultrasound emitter while rotating the ultrasound emitter about a rotation axis; and ablating heart tissue with the ultrasound energy to form a lesion outside of a pulmonary vein.. .
Vytronus, Inc.

Ultrasound automated fetal heartbeat identification

Ultrasound systems and methods provide a workflow to automatically identify a fetal heartbeat. A region of interest (roi) is identified in an ultrasound image and an roi icon is positioned around or over a fetal pole and/or fetal heart.
Koninklijke Philips N.v.

Heartbeat detection system and heartbeat detection method

A heartbeat detection system includes a doppler sensor configured to receive a reflective wave from a subject, to obtain a doppler signal; and a processor including a memory and a cpu. The processor executes applying a wavelet transform to the doppler signal based on a plurality of scale factors, to obtain a wavelet coefficient for each of the scale factors; detecting a plurality of peaks of the wavelet coefficient for each of the scale factors; calculating each peak interval between the peaks next to each other, and each difference between the peak intervals next to each other, for each of the scale factors; selecting one of the scale factors that has a minimum variation in the differences of the peak intervals, as an optimal scale factor; and measuring the peak intervals calculated based on the optimal scale factor as heartbeat intervals..
Keio University

Magnetic resonance 2d navigator technique

In a method and apparatus for producing respiration-corrected mr images of an examination volume containing the heart of a patient during respiratory movement of mr signals are recorded continuously during multiple cardiac cycles, each cardiac cycle having multiple time segments. One 2d navigator image data record per cardiac cycle is recorded during a time segment of that cardiac cycle, with k-space being filled along a cartesian trajectory such that a spatial resolution is achieved in two spatial directions of the examination volume.
Siemens Healthcare Gmbh

Heart rate estimation from face videos using quality based fusion

A system and method for real time estimation of heart rate (hr) from one or more face videos acquired in non-invasive manner. The system receives face videos and obtains several blocks as roi consisting of facial skin areas.
Tata Consultancy Services Limited

Electronic device and capturing contents

Disclosed is an electronic device. The electronic device according to an embodiment includes a memory and a processor electrically connected with the memory, wherein the processor is configured to obtain an identification of a portion of the media data and a sequence of heart rate (hr) data of a user of the electronic device while the portion of media data is output, and store, in the memory, the identification of the portion of the media data when the hr data sequence satisfies a specified condition..
Samsung Electronics Co., Ltd.

System and heart rate measurement

The heart rate of a subject can be measured on a regular basis during the subject's daily performance without causing the subject to take trouble to wear a special device or to feel bothersome to keep wearing a special device. A heart rate measurement system includes an intraoral electrode, a hand electrode, and a detection unit.
Renesas Electronics Corporation

Device and the geometric determination of electrical dipole densities on the cardiac wall

Disclosed are devices, systems, and methods for determining the dipole densities on heart walls. In particular, a triangularization of the heart wall is performed in which the dipole density of each of multiple regions correlate to the potential measured at various located within the associated chamber of the heart.
Acutus Medical, Inc.

Smart toilet with function of electrocardiographic lead monitoring

A smart toilet with a function of electrocardiographic lead monitoring, includes a toilet base, and further includes a body connected to the toilet base. The body is provided with a controller, and an electrocardiographic lead monitoring module, a display or voice prompt module, a power supply module for supplying power, which are electrically connected to the controller respectively.
Zhongshan Anbo Health Technology Co., Ltd.

Method, system, and graphic user interface for enabling a customer to access an artist profile and associated media file

A method and system for enabling a customer to access both an artist profile and associated artist media files for purchase through a web-based portable store. An artist profile may be hosted on, for example, a web site, sms/mms gateway, and a wap site.
Iheartmedia Management Services, Inc.

Mapping user notifications to specific media streams

A media automation system generates multiple instances of a media broadcast stream, which includes core content common to each of the instances of the media broadcast stream, and multiple spot blocks interspersed within the media broadcast stream. Each stream instance is associated with a particular media playout device.
Iheartmedia Management Services, Inc.

Biomarkers for heart failure

The application discloses circrnas as new biomarkers for the development of heart failure after myocardial infarction; methods for the prediction and diagnosis of heart failure are provided based on measuring said one or more circrnas; and kits and devices for measuring said circrnas and/or performing said methods. Further provided are methods for treating patients at risk of heart failure based on the evaluation of said one or more circrnas..
Luxembourg Institute Of Health (lih)

Wearable cardioverter defibrillator (wcd) system evaluating its ecg signals for noise according to tall peak counts

A wearable cardioverter defibrillator system includes a support structure that a patient can wear. The system also includes electrodes that contact the patient, and define two or more channels from which ecg signals are sensed.
West Affum Holdings Corp.

Systems and methods for treating cardiac arrhythmias

A leadless pacing device may include a power supply providing a power supply voltage, a housing having a first end, a second end, and a side extending between the first end and the second end, and a set of electrodes supported by the housing and in communication with the power supply. The housing may be angled to follow a contour of a patient's heart when the housing is positioned within the coronary sinus of the patient's heart.
Cardiac Pacemakers, Inc.

Systems and methods for treating cardiac arrhythmias

A leadless pacing device may include a power supply for providing a power supply voltage, a housing having a first end and a second end with a side extending between the first end and the second end, and a set of electrodes supported by the housing and in communication with the power supply. When leadless pacing device is disposed within a coronary sinus of a patient's heart, the housing may facilitate blood flow across the housing.
Cardiac Pacemakers, Inc.

Implantable medical device

Imd devices and treatment methods are discussed and disclosed. An imd having a lead adapted for placement in an internal thoracic vein (itv) of a patient may be employed to facilitate atrial sensing.
Cardiac Pacemakers, Inc.

Detection of noise signals in cardiac signals

Medical device systems include processing circuitry configured to acquire sensed cardiac signals associated with cardiac activity of a heart of a patient, and to analyze the sensed cardiac signals to determine if a noise signal is present within the cardiac signals.. .
Medtronic, Inc.

Coupling system between a medical device and implantation accessory

An assembly includes a medical device provided with an anchoring member adapted to penetrate tissue of a cavity of the heart. The assembly further includes an implantation accessory including an elongated tubular element provided with a fastening mechanism for handling and guiding the medical device to an implantation site.
Sorin Crm Sas

Device for releasing a pharmaceutical onto the skin of a patient

A wearable device for administering a pharmaceutical has a housing, a heart monitor disposed in the housing, a microprocessor connected to the heart monitor, a receptacle for holding a pharmaceutical disposed in the housing, the receptacle being in communication with a conduit leading out of the housing, an actuator connected to the receptacle and being configured to release the contents of the receptacle into the conduit upon a command from the microprocessor, and a power source disposed in the base body and being configured to power the microprocessor, the heart monitor and the actuator. The microprocessor is programmed to actuate the actuator to release the contents of the receptacle when a heart rate measured by the heart monitor falls outside a preprogrammed range..
Am Nod Inc.

Apparatus and monitoring the degree of integration between the functions of the heart and the lungs, and the therapeutic success of resuscitative interventions

A method, system and apparatus for assessing the coupling between lung perfusion and ventilation in a patient who is mechanically ventilated or who is breathing spontaneously through a conventional artificial airway is provided. Embodiments of the apparatus comprise an adaptor configured to fit between the artificial airway and mechanical ventilator, a measuring chamber in constant fluid communication with the adaptor via one or more measuring chamber sampling ports, and a monitoring unit where data obtained from temperature and relative humidity sensors located in the measuring is calibrated, sampled, logged and analyzed together with anthropometric patient data to display a coupling index qi and to enable ongoing diagnostic cardio-pulmonary monitoring of a patient by comparing changes in the patient's index during a monitoring interval..

Cannula having nitinol reinforced inflow region

An intravascular heart pump assembly can include a rotor with at least one impeller blade, and a cannula. The present application describes various cannulas that can be manufactured from multiple layers of material to improve flexibility, manufacturability, and durability without increasing an outer diameter of the cannula.
Abiomed, Inc.

Immunoglobulin-like molecules directed against fibronectin-eda

The present invention is concerned with immunoglobulin (ig)-like molecules or fragments thereof for use in treatment, prevention, or prevention of progression of adverse cardiac remodelling and conditions resulting from or relating to pressure-overload, such as heart failure, aneurysm formation and remote myocardial fibrosis and for use in improving angiogenesis, preferably after ischemic injury. The invention also provides nucleic acid molecules encoding said ig-like molecules, vectors comprising same, and host cells comprising same..
Encare Biotech B.v.

Percutaneous heart valve

A method of delivering a percutaneous heart valve is disclosed. The percutaneous heart valve includes an expandable frame having a plurality of cells and a valve seated inside the expandable frame.
Edwards Lifesciences Cardiaq Llc

Implantation of repair devices in the heart

Apparatuses and devices usable for annuloplasty are provided. These can include a plurality of helical tissue anchors and an annuloplasty structure for placement on a heart valve annulus.
Valtech Cardio, Ltd.

Implantation of repair devices in the heart

Apparatuses and devices usable for annuloplasty are provided. These can include a plurality of tissue anchors and an annuloplasty structure for placement on a heart valve annulus.
Valtech Cardio, Ltd.

Retainers for transcatheter heart valve delivery systems

A delivery device for an implantable medical device includes an inner shaft extending in a longitudinal direction and an outer sheath adapted to surround at least a portion of the inner shaft, the outer sheath being slideable relative to the inner shaft in the longitudinal direction. A compartment defined between the inner shaft and the outer sheath is adapted to receive the medical device in an assembled condition.
St. Jude Medical, Cardiology Division, Inc.

Low profile transcatheter heart valve

A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve.
Edwards Lifesciences Corporation

Mitral valve prosthesis implantation

A heart valve prosthesis and methods of its implantation are described herein. The prosthesis can be implanted in a heart of a patient by positioning an upper support of an anchoring element into a left atrium of the patient.
Micor Limited

Prosthetic valve for replacing mitral valve

A prosthetic apparatus for implantation in a native mitral valve includes a main body for placement within the native mitral annulus. The main body is compressible to a radially compressed state for delivery into the heart and is self-expandable from the compressed state to a radially expanded state for implantation.
Edwards Lifesciences Corporation

Devices for reducing left atrial pressure, and methods of making and using same

A device for regulating blood pressure between a patient's left atrium and right atrium comprises an hourglass-shaped stent comprising a neck region and first and second flared end regions, the neck region disposed between the first and second end regions and configured to engage the fossa ovalis of the patient's atrial septum; and a one-way tissue valve coupled to the first flared end region and configured to shunt blood from the left atrium to the right atrium when blood pressure in the left atrium exceeds blood pressure in the right atrium. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits.
V-wave Ltd.

Systems and mechanisms for deploying a docking device for a replacement heart valve

Systems and methods usable in delivering a docking device to a native valve of a patient's heart. A distal region of a delivery catheter can be positioned in an atrium of the heart and a distal tip can be positioned at or near a commissure of the native valve.
Edwards Lifesciences Corporation

Arrhythmia diagnostic and/or therapy delivery methods and devices, and robotic systems for other uses

Improved systems for diagnosing and/or treating arrhythmia of a heart makes use of an array of articulation balloons to control movement of a distal portion of a catheter inside the heart, and may be used to align a diagnostic or treatment tool with a target tissue surface region along or adjacent an inner surface of one of the chambers of the heart. The articulation balloons can generate articulation forces at the site of articulation, and the movement may provide greater dexterity than movements induced by transmitting articulation forces proximally along a catheter body that winds through a tortuous vascular pathway.
Project Moray, Inc.

Methods for accessing a left ventricle

Two minimally invasive therapeutic procedures, particularly for patients with congestive heart failure, may be performed separately or together. One procedure involves providing a valved passageway through the patient's left ventricular wall at the apex of the patient's heart and advancing instruments through the valved passageway to connect the valve leaflets of the patient's heart valve, e.g.
Trans Cardiac Therapeutics, Inc.

Mitral valve leaflet clip

A clip used to repair the tissue of a heart valve leaflet may include a shaft having a barb and a plurality of legs connected to the shaft. The plurality of legs may extend away from the barb in a first condition, and may extend towards the barb in a use condition.
St. Jude Medical, Cardiology Division, Inc.

Adjustable tether and epicardial pad system for prosthetic heart valve

Apparatus and methods are described herein for repositioning a tether attached to a prosthetic heart valve. In some embodiments, a method includes inserting a distal end portion of a snare device through an incision at a first location in a ventricular wall of a heart and within the left ventricle of the heart.
Tendyne Holdings, Inc.

Method and device for quantifying a respiratory sinus arrhythmia and use of said type of method or said type of device

In a method and a device for quantification of a respiratory sinus arrhythmia, a heart-rate curve is measured first and then the time elapsed between two heartbeats is determined and quantified by an analysis in the phase domain. A more informative quantification is obtained when suitable coefficients are used or the heart-rate curve is interpolated and/or detrended for the quantification..
Biosign Medical Ug

Heart rate detecting module and method

This instant disclosure provides a heart rate detecting module which includes an image sensor and a processor. The image sensor generates a plurality of image frames according to a light from a subject.
Pixart Imaging Inc.

Blood pressure estimating apparatus, estimating blood pressure, and non-transitory computer-readable recording medium having stored therein program for estimating blood pressure

A blood pressure estimating apparatus includes: a detecting unit that detects a first parameter representing a period length being a length of a period of a heartbeat of a living body; a processing unit that determines, using the detected first parameter, a change of a volume of at least one vessel among a plurality of vessels that resiliently deform in a mathematical model with respect to time, the mathematical model expressing blood flowing in a circulatory system of the living body with fluid flowing through a flow path formed by annularly coupling the plurality of vessels, and estimates blood pressure of the blood using the determined change and the mathematical model.. .
Tohoku University

Heart rate monitoring device, system, and increasing performance improvement efficiency

A heart-rate monitoring system for a monitoring subject for increasing performance improvement efficiency by the monitoring subject includes a heart-rate monitoring device having a sensor. The sensor is not in direct physical contact with the monitoring subject.
Emfit Oy

Body-worn sensor for characterizing patients with heart failure

The invention provides a sensor for measuring both impedance and ecg waveforms that is configured to be worn around a patient's neck. The sensor features 1) an ecg system that includes an analog ecg circuit, in electrical contact with at least two ecg electrodes, that generates an analog ecg waveform; and 2) an impedance system that includes an analog impedance circuit, in electrical contact with at least two (and typically four) impedance electrodes, that generates an analog impedance waveform.
Tosense, Inc.

Method and non-contact fast vital sign acquisition based on radar signal

Various examples are provided for non-contact vital sign acquisition. Information can be provided regarding vibrations of a target using a radar signal such as, e.g., non-contact vital sign measurement.
The University Of Florida Research Foundation, Inc.

Methods and systems using mathematical analysis and machine learning to diagnose disease

Exemplified method and system facilitates monitoring and/or evaluation of disease or physiological state using mathematical analysis and machine learning analysis of a biopotential signal collected from a single electrode. The exemplified method and system creates, from data of a singularly measured biopotential signal, via a mathematical operation (i.e., via numeric fractional derivative calculation of the signal in the frequency domain), one or more mathematically-derived biopotential signals (e.g., virtual biopotential signals) that is used in combination with the measured biopotential signals to generate a multi-dimensional phase-space representation of the body (e.g., the heart).

Methods and systems using mathematical analysis and machine learning to diagnose disease

Exemplified method and system facilitates monitoring and/or evaluation of disease or physiological state using mathematical analysis and machine learning analysis of a biopotential signal collected from a single electrode. The exemplified method and system creates, from data of a singularly measured biopotential signal, via a mathematical operation (i.e., via numeric fractional derivative calculation of the signal in the frequency domain), one or more mathematically-derived biopotential signals (e.g., virtual biopotential signals) that is used in combination with the measured biopotential signals to generate a multi-dimensional phase-space representation of the body (e.g., the heart).

Methods and systems using mathematical analysis and machine learning to diagnose disease

Exemplified method and system facilitates monitoring and/or evaluation of disease or physiological state using mathematical analysis and machine learning analysis of a biopotential signal collected from a single electrode. The exemplified method and system creates, from data of a singularly measured biopotential signal, via a mathematical operation (i.e., via numeric fractional derivative calculation of the signal in the frequency domain), one or more mathematically-derived biopotential signals (e.g., virtual biopotential signals) that is used in combination with the measured biopotential signals to generate a multi-dimensional phase-space representation of the body (e.g., the heart).

Automated cardiac volume segmentation

Systems and methods for automated segmentation of anatomical structures, such as the human heart. The systems and methods employ convolutional neural networks (cnns) to autonomously segment various parts of an anatomical structure represented by image data, such as 3d mri data.

Low field magnetic resonance imaging (mri) scanner for cardiac imaging

A low-cost magnetic resonance imaging (mri) apparatus that may be used for, e.g., cardiac mri (cmr). Cmr is a clinical imaging tool that can investigate a wide range of cardiac conditions by exploring changes in the anatomy, physiology, or dynamics of the heart.

Heat treatment system

The invention relates to a heat treatment system, in particular a roller hearth furnace. The heat treatment system comprises a useful space having a first area with a width b1 and a second area with a width b2, wherein the rollers are arranged in the first area, and wherein width b2 is greater than width b1.

Abhd5 and partial hdac4 fragments and variants as a therapeutic approach for the treatment of cardiovascular diseases

The present invention relates to abhydrolase containing domain 5 (abhds) and n-terminal fragments of hdac4 (hdac4-nt) and variants of the aforementioned peptides for the treatment and prevention of heart failure. The present invention further provides vectors for the cardiomyocyte-specific expression of said peptides and a test system comprising abhds for the identification of novel compounds which are useful for the treatment of heart failure..

Pacemaker with diagnostic intrinsic beat search

Regulating cardiac activity may include pacing the patient's heart at a starting pacing rate and instigating an intrinsic heart beat search algorithm that includes pacing at a reduced rate for a period of time and capturing electrical signals representative of cardiac electrical activity while pacing at the reduced rate in order to determine a presence or absence of intrinsic heart beats. If intrinsic heart beats are not detected, the heart may be paced at a further reduced rate for a period of time.

Multi-site ultrasonic wireless pacemaker-defibrillator

A system and method to monitor and control heart rhythms using ultrasonic signals, including providing pacing and defibrillation therapy, are provided. A device for monitoring and controlling heart rhythms includes an intra-cardiac implantable device having an ultrasonic transducer to receive and/or transmit ultrasonic signals, and pacing circuitry to convert an acoustic signal into an electrical signal to stimulate or control a cardiac rhythm.

Methods and systems for lowering blood pressure through reduction of ventricle filling

Systems and methods for reducing ventricle filling volume are disclosed. In some embodiments, a stimulation circuit may be used to stimulate a patient's heart to reduce ventricle filling volume or even blood pressure.

Devices and methods for treating heart failure

The present teachings provide a device to change the pressure in a chamber of a heart and methods of making and using thereof. One aspect of the present teachings provides a device comprising a frame (for example, a metallic frame) and a scaffold.

Aortic valve no exchange catheter

A medical device used to percutaneously gain access to a targeted site within a living body, for example the left ventricle of the heart. The device is comprised of an inner tubular member, outer tubular member, and an adjustable control handle.

Connecting device

A connecting device is provided for connecting a pipe or tube-shaped element to the heart or a blood vessel of a patient, comprising a suture ring that has an opening, which can be closed by means of a closure element and through which said pipe or tube-shaped element is guided in the axial direction. The closure element is secured to the suture ring by means of at least one elastic securing element.

Selective gene therapy expression system

The expression at toxically acceptable level of the protein in tissues other than the target tissues, especially in the heart.. .

Methods for treating heart failure using glucagon receptor antagonistic antibodies

The present disclosure relates to methods for treating or preventing heart failure using a glucagon receptor blocking agent. In various embodiments, the present disclosure relates to methods for treating or preventing heart failure (e.g., post-myocardial infarction heart failure), diabetic cardiomyopathy heart failure), and lateral ventricular (lv) remodeling, using antigen binding and antagonizing proteins, e.g., fully human antibodies, that specifically bind to and antagonize the function of the human glucagon receptor..

Compositions and methods for treating heart failure

The present invention relates to compositions and methods for the treatment of heart failure.. .

Fruit extracts

Provided an methods of making an extract of fruit of the solanaceae family wherein fruit is processed to optimise the platelet aggregation inhibiting activity of the extract. The methods involve preparing a start mix of homogenised fruit; separating a water soluble fraction from fruit solids; filtration of the water soluble fraction; and concentration of active agents in the filtration permeate.

Annuloplasty ring delivery catheters

Apparatus is provided for repairing a cardiac valve, the apparatus including a catheter sized for delivery through vasculature of a subject and an elongated and flexible annuloplasty structure having an elongated lumen and an annuloplasty structure axis extending along the lumen. The annuloplasty structure is sized and configured for delivery to a heart of the subject through the catheter substantially along a catheter axis of the catheter while the annuloplasty structure axis is substantially parallel to the catheter axis.

Systems, methods and devices for prosthetic heart valve with single valve leaflet

Devices and methods for supplementing and/or replacing native cardiac valve functionality, e.g., the mitral valve with a single prosthetic leaflet. An exemplary device is directed to dysfunctional mitral valves.

Affixing a loop to a cardiac valve annulus using anchors with cylindrically curved outer surfaces

Apparatuses and methods are disclosed for performing a procedure on a heart valve in which a loop of material contacts at least a portion of the annulus or the leaflets of a valve. Anchors are distributed about the loop and configured for implantation into the annulus or the leaflets in a forward direction and resist extraction in a backwards direction.

Delivery system having a short capsule segment and a cinch mechanism and methods of use thereof

A delivery system including a heart valve prosthesis and a delivery catheter. The delivery catheter includes an outer shaft component, an inner shaft component and a cinch mechanism.

Heart valve

A method of deploying a prosthesis within a native mitral valve is disclosed. The expandable frame preferably includes about twelve proximal anchors, wherein the proximal anchors have free ends positioned radially outwardly from the frame in an expanded configuration.

Mitral valve prosthesis delivery system

A heart valve prosthesis delivery system can include a first sheath, a second sheath, a check valve, a check valve control lines, and a heart valve prosthesis carried within the first sheath or the second sheath. The check valve can be carried within the first sheath or the second sheath.

Mitral valve prosthesis

An anchoring element for a heart valve prosthesis can include an upper support, a lower support, and a flexible connector. The upper support is configured to be positioned adjacent to a native valve structure of a patient.

Stented prosthetic heart valves

A surgical sutureless valve that is attached to a stent frame for delivery to a location in a patient using percutaneous implantation devices and methods.. .

Device, system, and transcatheter treatment of valvular regurgitation

The invention relates to a device for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance element for implantation across the valve; a system including the coaptation assistance element and anchors for implantation; a system including the coaptation assistance element and delivery catheter; and a method for transcatheter implantation of a coaptation element across a heart valve.. .

Sleep scoring based on physiological information

Assessing the sleep quality of a user in association with an electronic device with one or more physiological sensors includes detecting an attempt by the user to fall asleep, and collecting physiological information associated with the user. The disclosed method of assessing sleep quality may include determining respective values for one or more sleep quality metrics, including a first set of sleep quality metrics associated with sleep quality of a plurality of users, and a second set of sleep quality metrics associated with historical sleep quality of the user, based at least in part on the collected physiological information and at least one wakeful resting heart rate of the user, and determining a unified score for sleep quality of the user, based at least in part on the respective values of the one or more sleep quality metrics..

Systems, devices, and methods for performing trans-abdominal fetal oximetry and/or trans-abdominal fetal pulse oximetry using a heartbeat signal for a pregnant mammal

Light reflected from a pregnant woman's abdomen and fetus contained therein that has been received by a detector and converted into a reflected electronic signal may be received by a processor. A portion of the reflected electronic signal that is reflected from the fetus may be isolated and the isolated portion of the reflected electronic signal may be analyzed to determine a fetal hemoglobin oxygen saturation level of the fetus.

Heart monitor electrode system

A bioelectric interface for monitoring, detection and transmission of detected ecg data is provided comprising a sensory system for detecting bio-physiological measurements utilizing spatially resolved potential profiles obtained from a localized cluster of sub-electrodes to form constituent sets of miniature sensor arrays. Using only a single macro-electrode, two or more sets of sub-electrode arrays are used to measure bipolar spatial gradients obtained from measured cardiac potentials.

Wireless cardiac sensor

A wireless cardiac sensor is provided. The sensor may be utilized by a patient, on themselves, in an at home or other non-clinical environment.

Systems and methods for atrial arrhythmia detection

Systems and methods for detecting atrial arrhythmias such as atrial tachyarrhythmia (at) are described herein. An at detection system may include a heart rate detector circuit configured to detect, from a physiological signal, representative ventricular heart rates within heart rate analysis windows.

Low cost fetal phonocardiogram

A fetal phonocardiogram system featuring an array of acoustic sensors designed to be temporarily affixed to a pregnant patient to convert the vibrations associated with a fetal heartbeat and/or fetal movement into a signal. The signal can be amplified and transferred to a processing element for filtering non-fetal sounds in order to resolve the fetal heartbeat.

3-d electrophysiology heart simulation system and related methods

A system for simulating a medical procedure includes: a physical model of an organ including a sensor mesh; a camera system including a plurality of cameras having overlapping fields of view directed at the physical model of the organ; a user input device including a distal end inserted within the physical model of the organ; a display device; and a simulation controller coupled to the sensor mesh, the camera system, the user input device, and the display device, the simulation controller including a processor and memory, the memory storing instructions that, when executed by the processor, cause the processor to: initialize a simulation of the organ; display, on the display device, a representation of a state of the simulation of the organ; receive contact data from the sensor mesh; receive images from the cameras; compute a location of the distal end of the user input device within the physical model of the organ in accordance with the contact data and the images; receive user input from the user input device; update the state of the simulation of the organ in accordance with the user input; and display, on the display device, the updated state of the simulation.. .

Heart rate monitor

A heart rate monitor comprises a housing (30) and an optical heart rate (ohr) sensor within the housing (30). The ohr sensor comprises a sensing unit (40) including at least one light emitter (42a, 42b) arranged to emit light into the skin of a user and a photodetector (44) arranged to sense light reflected through the skin of the user.

Apparatus and heartbeat detection

According to an example aspect of the present invention, there is provided an apparatus for heartbeat detection, comprising: means for forming a first amplified signal and a second amplified signal on the basis of an input signal representative of heartbeat, means for forming a third signal by inverting the second signal and adding a base voltage, and means for indicating an overlap of the first signal and the third signal.. .

Device and controlling in-vivo pressure

A differential pressure regulating device is provided for controlling in-vivo pressure in body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens.
Klemm+sohn Gmbh & Co. Kg

Method and image processor for evaluating a contrast agent-enhanced magnetic resonance slice image of a heart

In a method and processor for evaluating a contrast agent-enhanced two-dimensional magnetic resonance slice image of a heart of a patient in order to determine picture elements revealing contrast agent deposits in the myocardium, an endocardium contour in the magnetic resonance slice image, taking into consideration deposition information describing picture elements potentially revealing contrast agent deposits and determined by image analysis on the basis of a shape assumption for the heart structure that is to be examined, in particular the left ventricle, such that picture elements potentially revealing contrast agent deposits are avoided as much as possible as a contour component. An epicardium contour enclosing the endocardium contour is then determined.
Siemens Healthcare Gmbh

Method of determining risk of an adverse cardiac event

Methods of determining the risk of an adverse cardiovascular event or death in a mammal are provided which include determining in a biological sample obtained from the mammal the level of a combination of biomarkers selected from a glucose metabolism biomarker, a heart function biomarker, a renal function biomarker and at least one biomarker of cardiac injury. A score is allotted based on the level of each biomarker, and the cumulative score is indicative of the risk of an adverse cardiovascular event..
Mcmaster University

Active magnetic bearing

An active magnetic rotor-bearing assembly for conveying a fluid comprising a rotor assembly is disclosed and a bearing assembly for contactless bearing the rotor assembly, where the bearing assembly comprises an even number of electromagnetic units arranged around a central structure each comprising a first salient established by a magnetic material and a permanent magnet providing a first magnetic pole and a coil around the salient, further comprises an inter joke with inter joke portions connected to the first salient of each electromagnetic unit and being separated from each other by structure spacers, providing a closed first magnetic flux passing the rotor assembly applying a first attractive force further comprising a position stabilizing portion perpendicular to the first attractive force on the rotor-assembly and the coils providing an electromagnetic flux between each first salient and the rotor assembly for applying adaptable axial force and/or tilting torque to the rotor assembly.. .
Reinheart Gmbh

Diagnostic transcriptomic biomarkers in inflammatory cardiomyopathies

Molecular signatures that function as very sensitive diagnostic biomarker for myocarditis, heart disease and disorders thereof, are identified.. .
University Of Miami

Use of mirco-rnas circulating in the blood serum or blood plasma for identifying patients requiring a biopsy and as a marker for the differential diagnosis of individual non-ischemic cardiomyopathies or storage diseases

The invention relates to the use of certain micro-rnas circulating in the blood serum or blood plasma in the form of diagnostic profiles as a marker in an in vitro method for distinguishing between patients for which a myocardial biopsy is necessary for the diagnostic identification of a heart muscle disease and patients for which myocardial biopsy is not necessary, and for the optional differential diagnosis of individual non-ischemic cardiomyopathies or storage diseases affecting the heart.. .
Ikdt Institut Kardiale Diagnostik Und Therapie Gmbh

Systems and methods for coordinating musculoskeletal and cardiovascular or cerebrovascular hemodynamics

Described herein are methods for determining a target musculoskeletal activity cycle (mskc) to cardiac cycle (cc) timing relationship. The method may include detecting a signal responsive to a cyclically-varying arterial blood flow at a location on a head of a user; providing a recurrent prompt at a frequency of the heart pump cycle using the signal, such that the signal correlates with a magnitude of blood flow adjacent to the location, and the recurrent prompt is provided to guide the user to time performance of a component of a rhythmic musculoskeletal activity with the recurrent prompt; and guiding the user to adjust a timing of the component of the rhythmic musculoskeletal activity to substantially maximize a magnitude of the signal.
Pulson, Inc.

Monitoring and stimulation module

Disclosed herein are portable and integrated modules and devices for non-intrusive neuromodulation and monitoring of heart function, and methods of operation thereof. The modules and devices include a monitoring unit, an electrical stimulation inducing unit, and at least four electrodes, being controllably utilized for neuromodulation or for monitoring of heart function..
Ziv Healthcare Ltd.

Artificial heart system

A blood pump system includes two blood pumps, which may be implanted into a patient. The blood pumps may comprise vad pumps.
Reliantheart Inc.

Composition and methods of use of novel phenylalanine small organic compounds to directly modulate pcsk9 protein activity

This invention is related to the field of pcsk9 biology and the composition and methods of use of small organic compounds as ligands for modulation of pcsk9 biological activity. In particular, the invention provides compositions of small organic compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein pcsk9.
Portola Pharmaceuticals, Inc.

Apparatus and guide-wire based advancement of an adjustable implant

A tissue-engaging element has a distal portion configured to engage a portion of tissue of the heart. A guide member is reversibly coupled to the tissue-engaging element.
Valtech Cardio, Ltd.

Methods, systems and devices for cardiac valve repair

Disclosed are methods, systems, and devices for the endovascular repair of cardiac valves, particularly the atrioventricular valves which inhibit back flow of blood from a heart ventricle during contraction. The procedures described herein can be performed with interventional tools, guides and supporting catheters and other equipment introduced to the heart chambers from the patient's arterial or venous vasculature remote from the heart.
Evalve, Inc.

Heart valve manufacturing devices and methods

Methods for manufacturing or sewing a prosthetic heart valve and associated systems can include an assistance system that includes an automated fixture that can comprise an articulation arm and a target device holder. The automated fixture can be configured to rotate a target device held by the holder.
Edwards Lifesciences Corporation

Heart valve docking devices and implanting methods

A system is in various embodiments configured to treat a native heart valve, such as to secure a prosthetic heart valve within a native valve. Embodiments of the system include a docking device with different coil portions, such as an upper coil and a lower coil, where the device is configured to assume an axially expanded state and an axially compressed state.
Edwards Lifesciences Corporation

Replacement heart valve system having docking station with sacrificial valve

A replacement heart valve system may include an expandable docking station configured for implantation within a native heart valve. The expandable docking station may include a plurality of sacrificial valve leaflets disposed within a braided anchoring element defining a lumen extending through the braided anchoring element.
Boston Scientific Scimed, Inc.

Telerobotic surgery system using minimally invasive surgical tool with variable force scaling and feedback and relayed communications between remote surgeon and surgery station

A telerobotic surgery system includes a robotic surgery station having a first pair of robot arms, each carrying a laparoscopic tool and each having a robot arm drive. A first controller is connected to each robot arm drive.
Kindheart, Inc.

Vascular access assembly declotting systems and methods

Methods of declotting vascular access technologies, such as vascular access assemblies that facilitate hemodialysis, are provided. The methods can include disposing a catheter within a patient to access a vascular access assembly within the heart of the patient.
Merit Medical Systems, Inc.

Post-implantation tension adjustment in cardiac implants

A method of treating a heart of a patient is provided, including implanting a first tissue anchor in cardiac tissue of the patient, the first tissue anchor attached to one or more tethers that are fixed to a coupling element. A second tissue anchor is implanted in the patient.
4tech Inc.

Deep learning algorithms for heartbeats detection

A system that detects heartbeats includes a sensor or a transducer and algorithms based on deep learning. The algorithms employ techniques of artificial intelligence that enable the system to extract heartbeat features under low signal-to-noise-ratio (snr) conditions when a user is exercising.
Logos Care, Inc.

Garment system with electronic components and associated methods

In embodiments, the system may be capable of monitoring multiple biometric responses including, but not limited to: skin temperature, core temperature, respirations, heart rate, predicted tidal volume, chest wall movement, abdominal movement in conjunction with inspiration, abdominal movement in conjunction with expiration, hrr (heart rate reserve), hrv (heart rate variability), body position relevant to perpendicular, shoulder position relevant to hip position, general body posture, up time, down time, and malfunctions.. .

Device, estimating the energy expenditure of a person

The present invention relates to a device for accurately estimating the energy expenditure of a person, in particular by which the effect of cardiovascular drift is taken into account. The device comprises an input unit (10) for obtaining a movement signal (13) representing physical activity of the person and a heart rate signal (15) representing the heart rate of the person, a cardiovascular drift determination unit (16) for determining cardiovascular drift phases (17) from said movement signal (13) and either said heart rate signal (15) and/or one or more cardiovascular drift related signals (23) carrying information on one or more of amount of sweat, weight loss, temperature rise, blood lactate concentration and physical fatigue of the person, a correction unit (18) for correcting the heart rate signal (15) generated and representing the heart rate during a cardiovascular drift phase, and an estimation unit (20) for estimating the energy expenditure of the person from the corrected heart rate signal (19)..
Koninklijke Philips N.v.

Microdialysis device comprising attachment sheet

The present disclosure relates to a dialysis device (1), more particularly a microdialysis device for the sampling of substances from the surface of a body organ. The device is particularly useful in the context of the monitoring of a moving organ, such as a beating heart, as the device comprises attachment means (2) allowing for a flexible and reliable attachment thereto.
Senzime Ab (publ.)

System and biometric ecg verification of patient identity

A system and method for verifying patient identity including a heart monitor, a memory, and a processor. The heart monitor may be adapted to collect a baseline ecg signal from a patient and a monitored ecg signal from the patient.
Medicomp, Inc.

Electrocardiogram analyzing method, electrocardiogram analyzing apparatus, electrocardiogram analyzing program, and computer-readable medium stored with the electrocardiogram analyzing program

An electrocardiogram analyzing method includes: (a) acquiring electrocardiogram data representing an electrocardiogram waveform having heart beat waveforms; (b) acquiring rr interval data from the electrocardiogram data; (c) detecting at least one premature ventricular contraction causing a compensatory pause; (d) extracting, from the rr interval data, rr intervals during the detected premature ventricular contraction and before and after the detected premature ventricular contraction; (e) extracting a first rr interval group and a second interval group respectively from the rr intervals, wherein the first interval group includes the intervals before the premature ventricular contraction, and the second interval group includes the intervals after the premature ventricular contraction; (f) performing a predetermined frequency analysis on the first rr interval group; (g) performing the frequency analysis on the second rr interval group; and (h) comparing a first analysis result obtained by the step (f) and a second analysis result obtained by the step (g).. .
Nihon Kohden Corporation

Device and monitoring and diagnosing the autoregular mechanism of the blood ...

A method of monitoring and/or diagnosing an autoregulation mechanism of blood pressure of a living being using an ecg signal includes recording the ecg signal of the living being, and the recording a pulse wave curve synchronously with the recording of the ecg signal. Heart rate intervals are determined from the ecg signal.
Schwarzer Cardiotek Gmbh

Information processing apparatus, method and non-transitory computer-readable storage medium

An information processing apparatus includes a memory, and a processor coupled to the memory and configured to acquire time series data of heart rate over a plurality of days, specify a first time zone of a day in which an increasing change of the heart rate satisfies a first condition in common with the time series data on the plurality of days, specify the increasing change in a second time zone of the day for each of the time series data on the plurality of days, the second time zone overlapped with at least a part of the first time zone, specify a meal time based on the increasing of the second time zone for each of the time series data, and output the specified meal time.. .
Fujitsu Limited

Method, system and computer programs for handling remote control of a cooking appliance to provide a customized diet

A method and a system for handling remote control of a cooking appliance to provide a customized diet. The method comprising performing following steps by a cloud computer server: storing one or more recipes including food preparation parameters for one or more cooking appliances; receiving one or more parameters of a plurality of users acquired by at least one measuring device, such as glucose level, blood level, weight, body mass index, temperature, and/or heartbeat; creating a customized diet plan for each of said plurality of users based on the received one or more parameters and the stored recipes; receiving identification data of a particular cooking appliance of a user of said plurality of users; and transmitting control instructions comprising a recipe, as a part of the diet plan, to an information interface integrated in said particular cooking appliance of said user or in a communications terminal of said user..
Taurus Research And Development, Slu

Digital range gated radio frequency sensor

A digitally implemented radio frequency sensor for physiology sensing may be configured to generate oscillation signals for emitting radio frequency pulses for range gated sensing. The sensor may include a radio frequency transmitter configured to emit the pulses and a receiver configured to receive reflected ones of the emitted radio frequency pulses under control of a microcontroller.
Resmed Sensor Technologies Limited

Sand bed downdraft furnace and activated carbon scrubber

A downflow hearth furnace includes a refractory-lined furnace lid. A burner is thermally coupled through the lid.
Kappes, Cassiday & Associates

Composition and methods of use of novel phenylalanine small organic compounds to directly modulate pcsk9 protein activity

This invention is related to the field of pcsk9 biology and the composition and methods of use of small organic compounds as ligands for modulation of pcsk9 biological activity. In particular, the invention provides compositions of small organic compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein pcsk9.
Portola Pharmaceuticals, Inc.

Methods for the prevention or treatment of heart failure

The disclosure provides methods of preventing or treating heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof..
University Of Washington

Nitroxyl donors with improved therapeutic index

The disclosed subject matter provides n-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure..
Cardioxyl Pharmaceuticals, Inc.

Methods for controlling the spread of dirofilariosis

This invention relates to a method of controlling the spread of dirofilariosis, such as for example heartworm, by administering to at least one non-human animal infested with filarioid nematodes such as dirofilaria spp or susceptible to have been infested with filarioid nematodes such as dirofilaria spp, an effective dose of a combination of a neonicotinoid compound and a pyrethroid compound.. .
Ceva Santè Animale

Method for reversing, preventing, delaying or stabilizing soft tissue calcification

The present invention provides methods of treating soft tissue calcification in a subject, comprising a step of administering to said subject an effective amount of ferric organic compound, such as ferric citrate. The claimed methods may prevent, reverse, delay or stabilize soft tissue calcification in a subject having chronic kidney disease.
Panion & Bf Biotech, Inc.

Systems and methods for treating preserved ejection fraction conditions

A device of a shape memory material configured to implement a predetermined level of expansion while allowing contraction and twist can be implemented in a portion of a vascular system, such as in the left ventricle of the heart of a patient suffering from heart failure with preserved ejection fraction.. .
Regents Of The University Of Minnesota

Transcatheter cardiac de-airing system

Systems and methods for de-airing a cardiac chamber during cardiac surgery are provided. A catheter-based inflatable device is inserted adjacent a target area of the heart, and the frequency of inflation and deflation of the inflatable device is controlled via a remote controller to change the shape of the cardiac chamber to dislodge air bubbles from their deposition site in the cardiac chamber..
The Cleveland Clinic Foundation

Method for replacing a heart valve

A method for replacing a native heart valve in need thereof comprises delivering to the native heart valve an apparatus comprising a valve member, a connecting member, and an anchor member suitable for anchoring the apparatus. The valve member reversibly moves between an open position and a closed position to augment or replace the function of the native valve leaflets, thereby reducing valve regurgitation.
Edwards Lifesciences Ag

Replacement heart valves, delivery devices and methods

A replacement heart valve and method of treating valve insufficiency includes an expandable frame configured to engage a native valve annulus. A valve body is coupled to the frame.
Edwards Lifesciences Cardiaq Llc

Replacement heart valves, delivery devices and methods

A replacement heart valve and method of treating valve insufficiency includes an expandable frame configured to engage a native valve annulus. A valve body is coupled to the frame.
Edwards Lifesciences Cardiaq Llc

High resolution multi-function and conformal electronics device for diagnosis and treatment of cardiac arrhythmias

The present invention is a high resolution, multi-function, conformal electronics device generally having a flexible and stretchable, high-density electrode array, integrated with a catheter (e.g., balloon catheter) for mapping, ablating, pacing and sensing of cardia tissue associated with heart arrhythmias. The active sensing electrode array can acquire diagnostic information including electrical (e.g., electrograms), mechanical (e.g., strain measurements), impedance (e.g., resistance), metabolic (e.g., ph or nadh measurement) from the underlying heart tissue surface with which it is in contact.
The George Washington University

Atrial appendage closure device and related methods

An atrial appendage closure device is provided that includes an occluding portion having a distal surface and a proximal surface opposite the distal surface, the occluding portion being moveable between a retracted position and a deployed position such that, in the deployed position, the occluding portion is configured to provide a seal between a left atrial appendage and a left atrium of a heart. An anchoring portion is operably connected to the occluding member with the anchoring portion being moveable between a retracted position and a deployed position.
University Of Louisville Research Foundation, Inc.

Suturing devices for heart valve surgery

Disclosed are devices and methods for delivering several sutures accurately and simultaneously around the perimeter of an annular prosthetic device (prosthetic heart valve, annuloplasty ring, etc.) to secure the prosthetic device within a native heart valve region. Devices can comprise a proximal handle portion including an actuator and a distal suturing portion including several curved and straight needles arrayed around the shaft axis.
Edwards Lifesciences Corporation

System and dynamic focusing on the heart and/or lungs by frequency tuning and analysis of phase and/or amplitude modulations

A wearable device for a patient includes a sock configured for wearing on a foot of a patient. A plurality of vital sign sensors is operably attached to the sock.
Koninklijke Philips N.v.

Method and device for measuring biometric data using uwb radar

A method and device for measuring biometric data using a uwb radar are disclosed. The disclosed method includes: (a) determining a respiratory rate by using reflection signals reflected off a target patient; (b) extracting respiration signals from the reflection signals, removing the extracted respiration signals from the reflection signals and converting into signals of a frequency domain; and (c) determining a heartbeat rate by detecting peak values from the frequency-domain signals converted in said step (b)..
Wrt Lab Co., Ltd.

Method and system for detecting information of brain-heart connectivity by using pupillary variation

Provided are a method and system for detecting information of brain-heart connectivity, the method comprising: obtaining moving images of a pupil and an electrocardiogram (ecg) signal from a subject; acquiring a pupil size variation (psv) from the moving images by separating the moving images at a predetermined time range after r-peak of the ecg signal; extracting signals of a first period and a second period from the psv; calculating alpha powers of the signals of the first and second periods at predetermined frequencies respectively.. .
Center Of Human-centered Interaction For Coexisten Ce

Accurate ecg i-point and j-joint detection and measurement

An ecg system measures and annotates the i-point of in an ecg waveform from harmonic waveforms. Electrical impulses are received from a beating heart.

Method and device for detecting a vital sign

A method of detecting a vital sign comprising at least one of a heart rate and a respiratory rate of a subject is provided. In one aspect, the method includes transmitting a radio frequency signal towards the subject; and receiving a reflected signal from the subject, wherein the transmitted signal is reflected by the subject and doppler-shifted due to at least one of the heart rate and the respiratory rate to form the reflected signal.
Stichting Imec Nederland

Aqua exercise glove

An exercise glove which provides a use with portable water and a means of increasing resistance throughout a variety of exercise. The exercise glove includes a glove body and a liquid-storage container.

System and sympathetic and parasympathetic activity monitoring by heartbeat

A system and method for analyzing a subject health condition based on an input signal comprising subject heartbeat data recorded from the subject over a time period. Using the subject heartbeat data, a sympathetic activity index value in a sympathetic activity index (sai) determined, where the sai represents an influence, on a mean heart rate of the subject, of sympathetic nerve activity (sna) of the subject..
The General Hospital Corporation

System for visualizing heart activation

The invention relates to a method and a system for providing a representation of synchronicity of electrical activation of heart tissue. The method includes obtaining a three-dimensional model of electrical activation of the heart.
Peacs B.v.

Predicting risk of major adverse cardiac events

Measurement of circulating st2 and natriuretic peptide (e.g., nt-probnp) concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, transplantation, and heart failure.. .
Critical Care Diagnostics, Inc.

Modification of broadcast media items based on feedback from streaming media player

A streaming media player receives a media stream from a first broadcast chain. Streaming performance feedback originating from the streaming media player is received at a processing system including an analytics module.
Iheartmedia Management Services, Inc.

Real-time processing system for information unit set, and method therefor

The present invention relates to a real-time processing system for an information unit set, comprising: a control operation unit, a time source unit and a user information unit set; wherein the time source unit is configured to provide time for the control operation unit; the time source unit is further configured to provide a heartbeat signal for each user's information unit set; said each user's information unit set comprises: a data input port, a data output port, a heartbeat line control switch and an information unit; each set of information unit in the user's information unit set further comprises: a steady-state storage module, a data output control switch of the steady-state storage module, an association exciter, a dynamic storage module and a data output control switch of the dynamic storage module.. .

Air-conditioning control system

This system correctly obtains a thermal sensation of a person in a room to provide a comfortable environment. A first parameter deriver derives, as a first parameter, a ratio of a low frequency component to a high frequency component in a variation of r-r intervals of a person, based on his/her body movement.
Daikin Industries, Ltd.

Wireless midfield systems and methods

Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters.
The Board Of Trustees Of The Leland Stanford Junior University

Systems and methods for rate responsive pacing with a leadless cardiac pacemaker

Systems and methods for providing rate responsive pacing therapy to a heart of a patient. One example method for providing rate responsive pacing therapy includes sensing cardiac electrical data with a leadless cardiac pacemaker (lcp) that is implanted within or proximate the heart.
Cardiac Pacemakers, Inc.

Hemodynamic performance enhancement through asymptomatic diaphragm stimulation

An implantable system, and methodology, for improving a heart's hemodynamic performance featuring (a) bimodal electrodes placeable on the diaphragm, out of contact with the heart, possessing one mode for sensing cardiac electrical activity, and another for applying cardiac-cycle-synchronized, asymptomatic electrical stimulation to the diaphragm to trigger biphasic, diaphragmatic motion, (b) an accelerometer adjacent the electrodes for sensing both heart sounds, and stimulation-induced diaphragmatic motion, and (c) circuit structure, connected both to the electrodes and the accelerometer, operable, in predetermined timed relationships to the presences of valid v-events noted in one of sensed electrical and sensed mechanical, cardiac activity, to deliver diaphragmatic stimulation. The circuit structure includes accelerometer-linked computer structure for enabling selective review, for later operational modifications, of stimulation-produced diaphragmatic motions, and in a modified form, may additionally include timing-adjustment substructure capable of making adjustments in the mentioned timed relationships..
Viscardia, Inc.

Methods and renal neuromodulation

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease.
Medtronic Ardian Luxembourg S.a.r.l.

Wire scaffold device for ventricular assist device

A ventricular assist system includes a ventricular assist device (“vad”) and an expandable stent. The vad may include a pump and an inlet element defining an inlet opening communicating with the pump, the inlet element being adapted for positioning with the inlet opening disposed within a ventricle of a heart when the system is in an operative condition.
Heartware, Inc.

Cardiac assistance system having two pumps

A cardiac assistance system is provided that comprises two pumps and cannulae connected thereto. A first pump of the two pumps is configured to connect to a right heart system via a first fluid channel.
Berlin Heart Gmbh

Apparatus and methods for optimizing intra cardiac filling pressures, heart rate, and cardiac output

Apparatus, systems, and methods are provided for optimizing intracardiac filling pressures and cardiac output in patients with heart failure, conduction disease, and atrial fibrillation. The system is able to adjust and optimize intracardiac filling pressures and cardiac output by adjusting heart rate and the effective amount of total body blood volume.
Cardioflow Technologies, Llc

Antibacterial combination of basil oil and taiwan red cypress oil for preventing drug-resistant s. aureus infections and the use thereof

The present invention relates to a combination of basil oil and taiwan red cypress oil exhibiting synergistic antimicrobial activity. The present combinations comprise two essential oils, leaves of basil (ocimum basilicum) and heartwood of taiwan red cypress (chamaecyparis formosensis matsum.), at a ratio of 1:2 to 2:1.
Chiuan Ho Biomedical Co.,ltd

Hand elevation device and methods of use

A hand elevation device is described that can position and secure a recovering hand and/or wrist for improved recovery. For example, the hand elevation device can secure a hand and/or wrist that has been operated on or injured in a therapeutic position.
Innovation Lab, Llc

Implantable device and delivery system for reshaping a heart valve annulus

Systems, devices and methods related to various heart valve implants and for delivery of those implants are described. The implants may be used to re-size a native valve annulus or to replace a native heart valve.
Millipede, Inc.

Delivery devices and methods for heart valve repair

Devices, systems and methods facilitate positioning of a cardiac valve annulus treatment device, thus enhancing treatment of the annulus. Methods generally involve advancing an anchor delivery device through vasculature of the patient to a location in the heart for treating the valve annulus, contacting the anchor delivery device with a length of the valve annulus, delivering a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus, and drawing the anchors together to circumferentially tighten the valve annulus.
Ancora Heart, Inc.

Methods for delivering a prosthetic valve

Methods for delivering a prosthetic valve comprise introducing the prosthetic heart valve into a body of a patient. The prosthetic valve is mounted within a delivery sheath of a delivery apparatus in a radially compressed state.
Edwards Lifesciences Corporation

Methods of loading a prosthetic valve in a delivery apparatus

Embodiments of the present disclosure provide methods of loading a prosthetic heart valve within a delivery apparatus such that it can be used for delivery of the prosthetic heart valve to a native valve site via the human vasculature. The methods can include attaching the prosthetic heart valve to a valve-retaining mechanism at a distal end of the catheter and causing a torque shaft of the delivery apparatus to rotate relative to the catheter, wherein the torque shaft extends within the catheter and is coupled to the valve delivery sheath.
Edwards Lifesciences Corporation

Prosthetic heart valve packaging and deployment systems

Packaging for prosthetic heart valves including an assembly for securely retaining a heart valve within a jar and facilitating retrieval therefrom. The assembly includes a packaging sleeve that fits closely within the jar and has a clip structure for securing a valve holder.
Edwards Lifesciences Corporation

Steerable assembly for delivering a prosthetic heart valve

An assembly for delivering a prosthetic heart valve to a native heart valve is disclosed. The assembly includes a self-expanding prosthetic heart valve formed with an expandable metallic stent and a flexible valvular structure.
Edwards Lifesciences Corporation

Stented prosthetic heart valve having wrap and methods of delivery and deployment

Systems and methods of delivering and deploying a stented prosthetic heart valve having a wrap that is automatically deployed to prevent or mitigate paravalvular leakage. In various embodiments, during transcatheter delivery of the stented prosthetic heart valve, the wrap is extends beyond a stent frame of the stented prosthetic heart valve so that the profile of the stented prosthetic heart valve is not increased during delivery.
Medtronic Vascular, Inc.

Decalcifying heart valve

Vascular valve systems for treating calcified vascular vessel valves by delivery of one or more calcium chelating agents are described. Methods of making the vascular valve systems are also described..
Boston Scientific Scimed, Inc.

Methods for treating patients via renal neuromodulation

A method and apparatus for treatment of heart failure, hypertension and renal failure by stimulating the renal nerve. The goal of therapy is to reduce sympathetic activity of the renal nerve.
Medtronic Ardian Luxembourg S.a.r.l.

Digital signal processing device and denoising heart rate detection module

A heart rate detection module including a ppg measuring device, a motion sensor and a processing unit is provided. The ppg measuring device is configured to detect a skin surface in a detection period to output a ppg signal.
Pixart Imaging Inc.

Wearable devices for physiological monitoring

A wearable device for detecting and/or measuring physiological information from a subject includes a housing, at least one optical emitter supported by the housing, at least one optical detector supported by the housing, a first light guide supported by the housing, a second light guide supported by the housing, a motion sensor supported by the housing, and a processor supported by the housing. The processor is configured to calculate footsteps, distinguish footsteps from heart beats, and to remove footstep motion artifacts from signals produced by the at least one optical detector.
Valencell, Inc.

Wearable physiological monitoring systems and methods

A physiological monitoring system can use physiological wearable monitors to collect and/or detect various parameters, such as cough, wheeze, heart rate, skin temperature, activity, respiration rate, skin impedance, electro-cardiogram data, blood pressure, galvanic skin response, and the like. One or more of these parameters, or other such parameters, may be used in methods in the fields of lung cancer, physiotherapy, monitoring disabled or challenged individuals, monitoring end of life conditions, monitoring breathing gas usage, monitoring patients and individual wellness, data acquisition, athletic sports monitoring, athletic sports entertainment, virtual reality feedback, telemedicine, hospital aid, illness detection and its severity, and public service, as examples.
Health Care Originals, Inc.

Systems and methods for classifying ecg data

A computer-implemented method for processing ecg data may include: receiving, over an electronic network, ecg data, wherein the ecg data represents a plurality of heartbeats; analyzing the ecg data, by at least one processor, to determine whether each of the plurality of heartbeats is a normal heartbeat or an abnormal heartbeat; associating, by the at least one processor, each of the abnormal heartbeats with either only one of a plurality of existing templates or a new template; receiving, from a user, input related to each new template, wherein the input includes either: a) a confirmation that the new template represents an abnormal heartbeat, or b) a reclassification of the new template as representing a normal heartbeat or a different abnormal heartbeat; and in response to the user input, updating, by the at least one processor, a label of each of the heartbeats associated with each confirmed new template and each of the heartbeats associated with each reclassified new template. The ecg data may be received from a portable monitor configured to be carried on a patient's body..
Infobionic, Inc.

Blood pressure measuring device, blood pressure measurement method and blood pressure measurement program

Provided are a blood pressure measuring device, a blood pressure measurement method and a blood pressure measurement program that allow calculating blood pressure properly even for ambulatory users. A blood pressure measuring device 1 is provided with: an electrocardiogram acquisition unit 11 that acquires an electrocardiogram of a user; a pulse wave acquisition unit 12 that acquires a pulse wave of the user; a first extraction unit 13 that extracts a heart rate on the basis of the electrocardiogram; a second extraction unit 14 that extracts a pulse wave velocity on the basis of the electrocardiogram and the pulse wave; a third extraction unit 15 that extracts one or a plurality of feature values pertaining to the pulse wave, on the basis of the pulse wave; and a calculation unit 16 that calculates blood pressure of the user from the heart rate, the pulse wave velocity and the one or plurality of feature values extracted for the user, by a learner 17 that has learned, by nonparametric regression analysis, a relationship between blood pressure of each of a plurality of subjects and a heart rate, a pulse wave velocity and one or a plurality of feature values pertaining to a pulse wave extracted for each of the plurality of subjects..
The University Of Tokyo

Device for measuring blood pressure and using the same

A device for measuring blood measure measures variations in electrical charges on the body as a result of heart activity. A method using the same is also described.
Rooti Labs Limited

Wireless sensor system with dynamic heartbeat message rate

A wireless sensor system includes a wireless sensor node with a sensor interface that interfaces with sensing circuitry, a wireless interface to communicate with a wireless access point, at least one processor, and memory having instructions stored thereon that, when executed by the at least one processor, cause the wireless sensor node to set a heartbeat message rate to a first heartbeat message rate. Heartbeat messages are sent periodically at the first heartbeat message rate, and sensor data are acquired through the sensor interface.
Sikorsky Aircarft Corporation

Rules-based user preferences for stream switching in an internet radio player

An internet radio player provides more personalized streaming audio content by assigning play amounts to different streaming media stations, and then playing streams from the different media stations at a playback device for play times corresponding to the respective play amounts. The play time for a given stream is calculated as a user-defined percentage for the associated stream source multiplied by an expected listening period.
Iheartmedia Management Services, Inc.

System and thermal management of a wearable computing device based on proximity to a user

Because the touch temperature of a wearable computing device (“wcd”) may be an insignificant factor for user experience when the wcd is not being worn by a user, embodiments of the solution seek to modify thermal management policies based on an inferred user proximity state. Exemplary embodiments monitor one or more signals from readily available sensors in the wcd that have primary purposes other than measuring user proximity.
Qualcomm Incorporated

System and methods for predicting drug-induced inotropic and pro-arrhythmia risk

A drug-induced risk prediction system and associated methods are disclosed for predicting at least one of a drug-induced inotropic risk and a pro-arrhythmia risk in connection with an at least one drug, based on a select at least one contractility parameter associated with an at least one heart.. .
Anabios Corporation

Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof

The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.. .
Bristol-myers Squibb Company

Method and a board game

They physical game apparatus is comprised of: a game board; four dice; 2 sets of 5 player totems that include one freemind, three energy totem pieces and 1 heart totem for each team; ten tokens; three pyramid tokens, 5 tradeoff coins and a stock certificate used for internet connectivity. To start the game a first roll is made where players pick up pair of die and shoot for highest possible number; the player with the highest number chooses order of play and to play with tokens and a choice between three or five tokens..

Charge balanced cardiac pacing from high voltage circuitry of an extra-cardiovascular implantable cardioverter defibrillator system

An extra-cardiovascular implantable cardioverter defibrillator (icd) having a high voltage therapy module is configured to control a high voltage charging circuit to charge a capacitor to a pacing voltage amplitude to deliver charge balanced pacing pulses. The capacitor is chargeable to a shock voltage amplitude that is greater than the pacing voltage amplitude.
Medtronic, Inc.

Silylated biomolecule-based hydrogel for culturing cardiomyocytes and stem cells, and use of the hydrogel thereof for treating heart failure

The present invention relates to the use of an hydrogel comprising silylated biomolecule for the three-dimensional culture of cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and to an aqueous composition comprising i) cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and ii) a hydrogel comprising silylated biomolecule, for use for treating heart failure, in particular heart failure following myocardial infarction.. .
Chu Nantes

Use of elafin for disorders associated with elastase independent increase in troponin

The present invention relates to the use of elafin for the treatment and/or prevention of diseases or disorders associated with an increase in troponin levels, which are non elastase dependent. The present invention in a preferred embodiment relates to a method and composition, using elafin, for protecting the heart muscle or other muscles from damage induced by abnormal blood flow and/or inflammation, which may result from, for example, a heart infarction.
Proteo Biotech Ag

Veterinary composition comprising torasemide for the treatment of pulmonary edema associated with heart failure in domestic animals

The invention relates to novel veterinary compositions comprising torasemide or a pharmaceutically acceptable salt thereof and administered in domestic animals according to a predetermined dosage for symptomatic treatment of pulmonary edema associated with heart failure.. .
Ceva Sante Animale

Treatment for the fetus with congenital heart disease

A method for treating injury or insult to the brain or nervous system caused by or associated with hypoxia, especially hypoxia associated with injury or insult to white matter in the foetal brain of a subject having congenital heart disease, by administering bh4.. .
Children's National Medical Center

Physiologically harmonized tricuspid annuloplasty ring

A prosthetic tricuspid remodeling annuloplasty ring having two free ends that are upturned in the inflow direction to help avoid unnecessary leaflet abrasion. The free ends are desirably separated across a gap that is large enough to reduce the risk of passing sutures through the conductive system of the heart, yet not too large that support of the septal leaflet of the tricuspid annulus is degraded.
Edwards Lifesciences Corporation

Post-implantation tensioning in cardiac implants

A method of treating a heart of a patient is provided. The method includes implanting a first tissue anchor in cardiac tissue of the patient and a second tissue anchor in the patient, such that the first and the second tissue anchors are coupled together by one or more tethers.
4tech Inc.

Systems and methods for heart valve therapy

Prosthetic heart valves described herein can be deployed using a transcatheter delivery system and technique to interface and anchor in cooperation with the anatomical structures of a native heart valve. Some embodiments of prosthetic valves described herein include an anchor portion that couples to the anatomy near a native valve, and a valve portion that is mateable with the anchor portion.
Caisson Interventional, Llc

Valve prosthesis

Heart valve prostheses are provided having a self-expanding frame that supports a valve body comprising a skirt and a plurality of coapting leaflets. The leaflets are constructed with four commissure points to reduce the stress and strain applied to the commissure points and to efficiently distribute and transmit forces along the leaflets and to the frame..
Medtronic Cv Luxembourg S.a.r.l.

Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet

Described embodiments are directed toward prosthetic valve leaflets of a particular shape that allows redundant coaptation height in the leaflets when a planar segment is present in each leaflet.. .
W. L. Gore & Associates, Inc.

System and treating heart tissue

Some embodiments of a system or method for treating heart tissue can include a control system and catheter device operated in a manner to intermittently occlude a heart vessel for controlled periods of time that provide redistribution of blood flow. In particular embodiments, the system can be configured to provide an estimation of the cumulative effects of the treatment.
Miracor Medical Sa

Methods of securing a cardiac implant using knotless suture clamps

Suture locking clamps for securing prostheses such as heart valves or annuloplasty rings with sutures and without using knots improve the ease of implantation. The clamps have opposed clamp halves separated by a slot opening to one side and surrounded by a biasing member such as one or more c-clip springs.
Edwards Lifesciences Corporation

Transcatheter heart valve leaflet plication

An apparatus for repairing a heart valve can comprises a leaflet-plicating mechanism configured to plicate a leaflet of a heart valve and a helical needle comprising a plurality of coils. The needle can be configured to implant a suture to extend helically through plicated tissue of the heart valve.
Edwards Lifesciences Corporation

Acoustic wave diagnostic apparatus and control method thereof

Periodic displacement occurs in body tissue due to heartbeat. A peak level d of the movement distance of the body tissue is detected (step 21), and a heartbeat cycle t is calculated from a frequency spectrum (steps 22 and 23).
Fujifilm Corporation

Devices and methods for measurement of vena cava dimensions, pressure and oxygen saturation

Catheter-based devices and methods for continuously monitoring vascular lumen dimensions, in particular in the inferior vena cava (ivc) for determining heart failure and/or fluid status of a patient. Related therapy systems and methods for integrated monitoring and therapy are also disclosed..
Foundry Innovation & Research 1, Ltd.

Method of detecting vascular condition based on point fluctuation conduction characteristics of the heart and device utilizing the same

A method of detecting the vascular condition based on point fluctuation conduction characteristics of the heart and a device utilizing the same are disclosed in this patent. The method comprises: attaching flexible detection terminals firmly against the external skin adjacent to the heart or vascular walls; discretizing the detection area of the heart muscle or vascular walls into a plurality of preset detection points; through active emission of ultrasonic waves and continuous array reception of ultrasonic echoes carrying out multidimensional inversion of point fluctuations/point pulse waves using backend inversion; taking the multiple point fluctuations of the heart muscle as the multiple input signals of the vascular system and the multiple point pulse waves of a certain detection location of the blood vessel as the multiple output signals of the vascular system; identifying the vascular conduction characteristics by using digital signal processing methods; obtaining the conduction characteristics of a certain section of the blood vessel by decomposing the vascular conduction characteristics at different locations based on the cascade feature of the blood vessel; through feature extraction and feature comparison realizing the prediction and diagnosis of the vascular condition and the corresponding symptoms.
Guangzhou Phonpad Information Technology Cooperation Limited

Methods and systems for scalable personalized breathing function

In some embodiments, the instant invention provides for a computer-implemented method, including: providing, to a user, in real time, by at least one specialized computing device being specifically programmed with wellbeing management software, at least one personalized breathing instruction via a graphical user interface displayed on the at least one specialized computing device, receiving, in real time, by the at least one specialized programmed computing device, user sensor data from at least one heart rate sensor being associated with the user, determining, in real time, by the at least one specialized programmed computing device, user heart rate variability of the user (user hrv), based, at least in part, on the user sensor data, automatically calculating, by the at least one specialized programmed computing device, a parameter status percentage; providing, to the user, at least one personalized breathing recommendation being configured to modify the parameter status percentage.. .
Eco-fusion

Methods of controlling biometric parameters via musical audio

A method of controlling a biometric parameter, such as heart rate and/or breathing rate, of a subject engaged in an activity includes sensing the biometric parameter via a monitoring device worn by the subject, determining frequency characteristics of the biometric parameter, and presenting to the subject musical audio having a tempo correlated to the frequency characteristics of the biometric parameter. The tempo of the musical audio presented to the subject may be changed in order to cause a change in the biometric parameter.
Valencell, Inc.

Automated segmentation utilizing fully convolutional networks

Systems and methods for automated segmentation of anatomical structures (e.g., heart). Convolutional neural networks (cnns) may be employed to autonomously segment parts of an anatomical structure represented by image data, such as 3d mri data.
Arterys Inc.

Automated segmentation utilizing fully convolutional networks

Systems and methods for automated segmentation of anatomical structures (e.g., heart). Convolutional neural networks (cnns) may be employed to autonomously segment parts of an anatomical structure represented by image data, such as 3d mri data.
Arterys Inc.

Method and magnetic resonance acquiring diagnostic measurement data of a heart

In a method and magnetic resonance apparatus for recording diagnostic measurement data of a heart of an examination object, the magnetic resonance apparatus is operated by a control sequence wherein an rf pulse excites nuclear spins with a flip angle of at least 60°, the diagnostic measurement data are recorded in a coordinate system independent of the heart, and the basic magnetic field produced by the magnetic resonance apparatus is smaller than 1.0 tesla.. .
Siemens Healthcare Gmbh

Il1rl-1 as a cardiovascular disease marker and therapeutic target

This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to diagnose and/or treat cardiovascular conditions including cardiac hypertrophy, myocardial infarction, stroke, arteriosclerosis, and heart failure..
Brigham & Women`s Hospital, Inc.

Heart rate based control of cardiac resynchronization therapy

In some examples, controlling delivery of cardiac resynchronization therapy (crt) includes storing, in a memory of an implantable medical device system and in association with each of a plurality of heart rates, at least one respective value for an interval between an atrial event and a ventricular event. Processing circuitry of the implantable medical device system may determine a heart rate of a patient and select one of the stored values for the interval between the atrial event and the ventricular event associated with the determined heart rate.
Medtronic, Inc.

Systems and methods for cardiovascular conditioning

An example system has a pulse generator configured to deliver a first series of electrical signals to a right atrium of a heart. The first series of electrical signals can increase a first heart rate toward a target heart rate.
University Of Iowa Research Foundation

Implantable medical device

Imd devices and implantation methods are discussed and disclosed. Electrode structures may be employed to allow electrical stimulation to heart tissue and/or sense a physiological condition.
Cardiac Pacemakers, Inc.

Micrornas for the treatment of heart diseases

The invention relates to the field of molecular biology and medicine, more specifically the invention is directed towards the treatment, delay and amelioration of heart diseases. More in particular, micrornas are provided that induce cardiac regeneration by inducing cell cycle proliferation of cardiomyocytes, thereby treating or ameliorating heart diseases associated with a loss of cardiomyocytes or cardiomyocyte function.
Academisch Ziekenhuis Maastricht

Cardiac valve downsizing device and method

A device for repairing a heart valve comprises a medical device (10). The medical device (10) comprises an element in order to downsize the annulus upon insertion and allow the leaflets to open and close properly.
Medtentia International Ltd. Oy

Heart valve prostheses including torque anchoring mechanisms and delivery devices for the heart valve prostheses

A delivery device for delivery and deployment of a heart valve prosthesis with a torque anchoring mechanism includes a balloon having a shaped surface configured to engage a corresponding shaped surface of the heart valve prosthesis. The balloon is configured to rotate about a central longitudinal axis of the delivery device to rotate the heart valve prosthesis..
Medtronic Vascular, Inc.

Prosthetic heart valve having identifiers for aiding in radiographic positioning

A prosthetic heart valve having identifiers for aiding in radiographic positioning is described.. .
Medtronic, Inc.

Transcatheter heart valve replacement systems, heart valve prostheses, and methods for percutaneous heart valve replacement

A transcatheter heart valve prosthesis configured in accordance herewith includes an expandable frame having a plurality of commissure posts extending therefrom, a radially expandable tubular component inflow member attached to the plurality of commissure posts, and a locking mechanism operably coupled to a wire. The wire is at least partially slideably disposed within a channel formed in a wall of the tubular component inflow member and the locking mechanism is configured to permit the wire to be advanced within the channel to thereby transition the inflow member tubular component into a deployed configuration that at least partially engages tissue at the native heart valve..
Medtronic, Inc.

System for stimulating renal nerves

The invention relates to a system (1) for stimulating renal nerves of a renal artery of a subject (3). The system comprises a stimulation device (12, 17, 28) for stimulating the renal nerves, a measuring unit (20) for measuring the blood pressure and/or the heart rate of the subject at at least two times, wherein at least one of these times is during or after the stimulation of the renal nerves, and a subject suitability determination unit (14) for determining whether the subject is suitable for a renal sympathetic denervation procedure based on the measured blood pressure and/or the measured heart rate.
Koninklijke Philips N.v.

Methods of ensuring pulsed field ablation generator system electrical safety

A system and method for the safe delivery of treatment energy to a patient, which includes verification of system integrity before, during, or after the delivery of treatment energy and provides several mechanisms for rapid termination of the delivery of potentially harmful energy to the patient when a fault condition in the device and/or system is identified. The system may include an energy generator having processing circuitry to determine if there is a fault condition in the system and to automatically terminate a delivery of treatment energy when the processing circuitry determines there is a fault condition.
Medtronic, Inc.

Fracturing calcifications in heart valves

A device for fracturing calcifications in heart valves including an expandable stabilizer and expandable impactor arms assembled on and deployed by a delivery system, wherein the delivery system is operable to move the impactor arms, while in an expanded position, with respect to the stabilizer with sufficient energy so as to fracture a calcification located in tissue which is sandwiched between the stabilizer and the impactor arms.. .
Pi-cardia Ltd.

X-ray imaging apparatus and x-ray image analysis

An x-ray imaging apparatus includes an x-ray irradiation element, an x-ray detection element, an x-ray image generation element, and an image processing analysis element. The image processing analysis element reflects the analysis point on each frame based on a respective relative location between a characteristic point 10 of the x-ray image consisting of a plurality of frames.
Shimadzu Corporation

Drowsiness onset detection

Drowsiness onset detection implementations are presented that predict when a person transitions from a state of wakefulness to a state of drowsiness based on heart rate information. Appropriate action is then taken to stimulate the person to a state of wakefulness or notify other people of their state (with respect to drowsiness/alertness).
Microsoft Technology Licensing, Llc

Neck-worn physiological monitor

The invention provides a neck-worn sensor that is a single, body-worn system that measures the following parameters from an ambulatory patient: heart rate, pulse rate, pulse oximetry, respiratory rate, temperature, thoracic fluid levels, stroke volume, cardiac output, and a parameter sensitive to blood pressure called pulse transit time. From stroke volume, a first algorithm employing a linear model can estimate the patient's pulse pressure.
Tosense, Inc.

Meal detection devices and methods

Devices and methods for detecting meal intake are disclosed herein. In some embodiments, one or more sensors can be used to detect or monitor physiological parameters of a user (e.g., heart rate, body movements, temperature, ph, impedance, gastric stretch, sound emissions, and the like).
Ethicon Llc

Cochleopalpebral reflex test

The cochleopalpebral reflex test is an electroacoustic transducer that emits a harmless sound stimulus that induces the cochlea palpebral reflex and the subsequent variation in the heart rate of the fetus that is detected as described in the prior paragraph. The cochleopalpebral reflex test consists of a housing, a transducer, an amplifier, and a signal source.

Device and the geometric determination of electrical dipole densities on the cardiac wall

Disclosed are devices, a systems, and methods for determining the dipole densities on heart walls. In particular, a triangularization of the heart wall is performed in which the dipole density of each of multiple regions correlate to the potential measured at various locations within the associated chamber of the heart..

Device, detection and processing of heartbeat signals

A heart beat detection device comprises at least one optical reflection sensor to be positioned on the skin of a person. The sensor unit is provided with a light emitter and a corresponding light receiver which converts the light reflected by the skin into an electric signal and comprises electrically adjustable optical filters connected to the emitter, to the receiver or to both of them in order to select, upon operation, a desired light wavelength and perform processing of the signals thus obtained in order to reinforce the heart beat signal.
Empatica Srl

Determining blood pulse characteristics based on stethoscope data

Techniques for determining pulse transit time (ptt) and blood pressure measurements based on stethoscope data are provided. In one example, a system comprises a stethoscope component that monitors a heart and generates stethoscope data representative of a sound wave generated by the heart.
International Business Machines Corporation

Determining blood pulse characteristics based on stethoscope data

Techniques for determining pulse transit time (ptt) and blood pressure measurements based on stethoscope data are provided. In one example, a system comprises a stethoscope component that monitors a heart and generates stethoscope data representative of a sound wave generated by the heart.
International Business Machines Corporation

Apparatus and determining blood pressure

An apparatus and method for determining blood pressure has a control unit and a device for providing pulse wave data representative of a heart beat of a human subject. The subject has a body height, an age, and a gender.
Preventicus Gmbh

Piezoelectric related extracting cardiac cycle features from respiration signals

A method and system for extracting cardiac cycle parameters from a respiration signal is disclosed. The technique comprises an array of piezoelectric sensors planted on the chest.
United Arab Emirates University

Relating to heart monitoring

Described herein is a multi-dimensional kineticardiography device (300) which comprises a sensor (320) having three accelerometer/gyroscope modules (320x, 320y, 320z) mounted in a support which positions it at the centre of mass of a subject whose cardiac function is to be measured. The sensor (320) outputs six degrees of freedom data as linear acceleration along and rotational or angular velocity about x-, y- and z-axes.
UniversitÉ Libre De Bruxelles

Troubleshooting method and apparatus

This application provides a troubleshooting method and apparatus. The troubleshooting method includes obtaining key performance indicator (kpi) information of each service processor in a monitored network element; determining a faulty object according to the kpi information; determining a troubleshooting policy according to the faulty object; and sending the troubleshooting policy to a management unit in a network function virtualization (nfv) system, so that the management unit uses the troubleshooting policy to perform troubleshooting.
Huawei Technologies Co., Ltd.

Dynamic adjustment of an annuity based on wellness monitoring of a participant

A computer-implemented method, system and computer program product for dynamic adjustment of an annuity based on wellness monitoring of a participant is described. Investment data is accessed including capital amount data relating to a capital amount to be invested for the person, investment selection data relating to an investment selection of how the capital amount is to be invested, and periodic payment amount relating to the selected periodic payment amount to be paid to the person.
Discovery Limited

Measurement of health-related activity using sensors

A system and method for measuring health-related activity from a participant. The method includes measuring a health-related activity of a participant including heart rate, active calories, and a number of steps from one or more wearable devices on the participant.
Destiny Health, Inc

Method for generating a machine heartbeat

A method and system for generating a heartbeat of a process including at least one machine configured to perform a process cycle consisting of timed events performed in a process sequence includes determining the duration of each timed event during performance of the process cycle, ordering the durations of the timed events in the process sequence, and generating a heartbeat defined by the ordered durations of a process cycle. One or more process parameters can be sensed and displayed with the heartbeat in real time.
Beet, Llc

Mobile defibrillator for use with personal multifunction device and methods of use

A portable defibrillator system includes a personal multifunction device and a portable defibrillator device for delivering a dose of electric current to a heart for ending the dysrhythmia and allowing the heart to re-establish a normal sinus rhythm. A portable defibrillator case contains defibrillation circuitry supporting the generation and transmission of a dose of electric current.
Smart Savior

Intra-body device communication with redundant message transmission

Implantable medical devices (imd), such as but not limited to leadless cardiac pacemakers (lcp), subcutaneous implantable cardioverter defibrillators (sicd), transvenous implantable cardioverter defibrillators, neuro-stimulators (ns), implantable monitors (im), may be configured to communicate with each other. In some cases, a first imd may transmit instructions to a second imd.
Cardiac Pacemakers, Inc.

Temporal configuration of a motion sensor in an implantable medical device

Methods and devices for configuring the use of a motion sensor in an implantable cardiac device. The electrical signals of the patient's heart are observed and may be correlated to the physical motion of the heart as detected by the motion sensor of the implantable cardiac device in order to facilitate temporal configuration of motion sensor data collection that avoids detecting cardiac motion in favor of overall motion of the patient..
Cardiac Pacemakers, Inc.

Method of operating an integrated balloon catheter inflation system

An inflation system having two pressure vessels integrated into a balloon catheter. A pressurized chamber and a vacuum chamber are integrally attached to proximal end of the balloon catheter and activated by a common valve or switch.
Edwards Lifesciences Corporation

Deflectable catheter with a flexibly attached tip section

A catheter for mapping and/or ablating a region of the heart includes an intermediate section that is connected to a tip assembly at a preset angle by a flexible preshaped section that is more flexible than the intermediate section. The flexible section may absorb displacement force applied to the tip assembly, such as when the tip assembly encounters uneven tissue surface, without displacing the intermediate section.
Biosense Webster, Inc.

Counterpulsation device driver apparatus, method and system

A method of operating a counterpulsation device (cpd) in a human or animal subject is disclosed, the method including: receiving a heart beat signal indicative of the heart beat of the subject; providing counterpulsation therapy by controlling the pressure supplied to a cpd drive line in pneumatic communication with the cpd to cause the cpd to alternately fill with blood and eject blood with a timing that is determined at least in part based on the heart beat signal; while providing counterpulsation therapy, receiving a cpd drive line pressure signal indicative of the pressure in the cpd drive line; and adjusting the pressure supplied to the drive line based at least in part on the drive line pressure signal.. .
Abiomed, Inc.

Device and a augmenting heart function

A device, a kit and a method are presented for permanently augmenting the pump function of the left heart. The basis for the presented innovation is an augmentation of the physiologically up and down movement of the mitral valve during each heart cycle.
Synergio Ag

Cardiac assist device

A cardiac pump and an assist system is provided that increases blood ejection from a compromised heart. An implantable cardiac pump acting as an assist device provided includes an attachment system and locating features that enable a minimally invasive procedure to implant and deploy one or more aortic blood pumps in a patient.
Viaderm Llc

Intracardiac pumping device

The invention relates to an intercardiac pump device comprising a pump (11) whose distal end (13) is connected to a cannula (15) which is provided with a suction head (16) for sucking blood. Said strainer is provided with a non-sucking extension (20) for stabilising the position of said pump device in the heart and mechanically prolonging the cannula (15) without deteriorating hydraulic conditions.
Abiomed Europe Gmbh

Lactobacilli for treating cardiac dysfunction

The use of a bacterium of the species lactobacillus salivarius in the manufacture of a food product, dietary supplement or medicament for treating cardiac dysfunction, particularly myocardial infarction, congestive heart failure, dilated cardiomyopathy or inflammatory heart disease (including endocarditis, inflammatory cardiomegaly and myocarditis) is disclosed.. .
Dupont Nutrition Biosciences Aps

Bifidobacteria for treating cardiac conditions

This invention relates to new uses of bifidobacteria (particularly, although not exclusively, probiotic bifidobacteria), and to food products, feed products, dietary supplements and pharmaceutical formulations containing them. The bacteria are suitable for the treatment of myocardial infarction and congestive heart failure..
Dupont Nutrition Biosciences Aps

Selective inhibitors of alpha2-containing isoforms of na,k-atpase and use thereof for reduction of intraocular pressure

Provided herein are alpha2-selective na,k-atpase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.. .
Yeda Research And Development Co., Ltd.

Delivery systems and methods of implantation for prosthetic heart valves

A delivery system for delivering an implantable stented device to a lumen of a patient, the delivery system including an elongated body having a proximal end and a distal end, a driver mechanism positioned at the proximal end of the elongated body, an elongated threaded rod located axially distal to the driver mechanism, and a sheath including an elongated tubular portion having a hollow interior portion with a first diameter that is sized for compression and retention of the implantable stented device in a compressed configuration for delivery to a body lumen.. .
Medtronic, Inc.

Heart valve repair devices and methods

Devices and methods for the repair of the functioning of heart valves are provided. A device may comprise a first section having a generally spiral shape and a second section connected to the first section.
Mitralix Ltd.

Chordae tendineae adjustment

A method for improving leaflet prolapse and/or valve regurgitation associated with a heart valve involves introducing a chordae tendineae capturing device into a ventricle of a heart, the chordae tendineae capturing device comprising a central hub component and a plurality of spokes, extending the plurality of spokes outward from the central hub component, rotating the chordae tendineae capturing device in a first direction to bring at least one of the plurality of spokes into physical contact with one or more cords of chordae tendineae disposed in the ventricle, further rotating the chordae tendineae capturing device in the first direction to bring the one or more cords inward towards the central hub component, and closing the plurality of spokes at least partially over the one or more cords to secure the one or more cords.. .
Edwards Lifesciences Corporation

Methods and endovascularly replacing a heart valve

The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; and applying an external non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to change the shape of the anchor, such as by applying proximally and/or distally directed force on the anchor using a releasable deployment tool to expand and contract the anchor or parts of the anchor.
Boston Scientific Scimed, Inc.

Transcatheter delivery systems and delivery catheters for prosthetic mitral valve delivery, and methods for prosthetic mitral valve delivery using a retrograde approach

Transcatheter delivery systems, delivery catheters and associated methods for percutaneous delivery of prosthetic mitral valves using a retrograde approach are disclosed herein. A heart valve delivery system configured in accordance herewith includes a delivery catheter having an elongated tubular component and an articulation assembly at a distal end thereof.
Medtronic Vascular, Inc.

Systems, methods and devices for two-step delivery and implantation of prosthetic heart valve

A two-step delivery method, system and device is disclosed comprising, in various embodiments, a self-expanding frame. A self-expanding frame is delivered and expanded within a heart chamber followed by delivery of a prosthetic valve comprising prosthetic valves thereon into the expanded self-expanding frame, which is in turn connected to a valve connection region defined on and by the delivered and expanded frame..
4c Medical Technologies, Inc.

Covered prosthetic heart valve

A prosthetic heart valve includes a frame having a plurality of strut members, an inflow end, and an outflow end. The prosthetic heart valve further includes a leaflet structure situated at least partially within the frame, and a covering disposed around the frame.
Edwards Lifesciences Corporation

Method and device for treatment and prevention of fluid overload in patients with heart failure

Various aspects of the present disclosure are directed toward apparatuses, systems and methods that include arranging an implantable flow restriction device within the aorta of a patient. The methods may also include physical dimensions of the implantable flow restriction device..
W. L. Gore & Associates, Inc.

Dry prosthetic heart valve packaging system

Packaging for prosthetic heart valves including an assembly for stabilizing dry prosthetic tissue implants such as heart valves during storage. The packaging assembly can be used for storing a bioprosthetic heart valve without a liquid preservative solution.
Edwards Lifesciences Corporation

Method and system for eliminating a broad range of cardiac conditions by analyzing intracardiac signals providing a detailed map and determining potential ablation points

A system and method for improving ablation procedures is presented. The method may comprise measuring egm signals; performing three dimensional mapping of the egm signals; and detecting a location for ablation based on the mapping.
Biosense Webster (israel) Ltd.

Epicardial access system & methods

A method and apparatus are disclosed for a needle for gaining access to the pericardial cavity of a heart. The needle includes an elongate member (e.g.
Baylis Medical Company Inc.

Devices, creation of a peripherally located fistula

Devices, systems and methods are disclosed for the formation of an arteriovenous fistula in the limb of the patient. Embodiments include a device for the creation, modification and maintenance of a fistula that includes an integral fistula creation assembly near its distal end that passes through the skin of the patient, through a first vessel such as an artery, and into a second vessel such as a vein.
Rox Medical, Inc.

System and measuring effectiveness of autonomic neurostimulation

A system for evaluating an efficacy of vagus nerve stimulation is provided, wherein the system has a neurostimulator that is configured to perform vagus nerve stimulation, and a measuring component for evaluating the efficacy based on at least one parameter that is indicative of a myocardial contractile state of the heart. A corresponding method is also provided..
Biotronik Se & Co. Kg

Wearable devices for assisting parkinson's disease patients

A parkinson's disease (pd) sensor system, including multiple inertial sensors and a heart rate monitor, may be used to detect pd symptoms, including freezing of gait (fog). The pd sensor system may include a wrist-mounted accelerometer and heart rate monitor, and additional inertial sensors at other parts of the patient's body.
Intel Corporation

Sleep apnea therapy enhancement method and apparatus

Apparatuses, methods and storage medium associated with enhancing sleep apnea therapy are disclosed herein. In embodiments, an apparatus may comprise one or more light sources to project light onto a user; one or more optical sensors to sense light reflected off the user; and an analyzer coupled with the one or more optical sensors to receive, process and analyze the sensed light data for at least features of heart rate variability signals to determine an apnea condition of the user; wherein the determined apnea condition of the user is used to control an apap device for the user.
Intel Corporation

Apparatus and imaging and analyzing hemodynamics

The present invention images a heartbeat strength representing the strength of pulsations (beats) on a map as a new dynamics index different from the conventional waveform numerical value. A computation section according to the present invention obtains, from time-course changes of the blood flow map obtained as a result of computation of blood flow speed, a signal intensity at a fundamental frequency determined from time-series blood flow data within a predetermined region, and calculates a heartbeat strength which represents the strength of heartbeats on the basis of the signal intensity.
Softcare Co., Ltd.

Head-mounted device for capturing pulse data

Examples are disclosed herein related to a head-mounted device, such as wearable eyeglasses, to continuously monitor pulse data and blood pressure data. One example provides a head-mounted device, comprising a first optical sensor positioned to measure pulse data at a first arterial location that is a first distance from a heart, a second optical sensor spaced apart from the first optical sensor and positioned to measure pulse data at a second arterial location that is a second, different distance from the heart, and a controller wired to the first optical sensor and the second optical sensor and configured to determine blood pressure data from the pulse data measured by the first optical sensor and the second optical sensor..
Microsoft Technology Licensing, Llc

Wrist type measurement of cardiovascular health, system, and method thereof

The disclosure is related to a wrist type apparatus, and a system for measurement of cardiovascular health, and a method for the same. The wrist type apparatus is preferably a wrist type blood pressure device that includes an electrode-based module and a piezoelectric sensor module.
Kentec Inc.

Caladium plant named 'restless heart'

A new and distinct cultivar of caladium plant named ‘restless heart’, characterized by its intermediate height and upright plant habit; leaf petioles upright to outwardly leaning with development; vigorous growth habit and rapid growth rate; fancy type leaves that are very dark green in color with red-colored venation and interveinal areas that are reddish pink in color with random red orange and green coalescing spots and splotches; and petioles that are tan green and distally, tan pink in color.. .
Walters Gardens, Inc.

Sharing historical user preferences across wireless radio receivers

A method includes a media services system maintaining user preference data, including historical listening patterns associated with situational parameters user preference data from a first wireless receiver in memory. The method continues with the media service system receiving current situational parameters from a second wireless receiver and comparing the situation parameters to the historical listening patterns with situation parameters from the first wireless receiver.
Iheartmedia Management Services, Inc.

Digital radio channel error detection

A method includes determining, at a device, that transmission data indicates that first data was transmitted via a digital radio channel. The method also includes determining, at the device, that reception data indicates that second data was received via the digital radio channel.
Iheartmedia Management Services, Inc.

Primary bounding area transport protocol experts group frames

A method includes configuring a plurality of sub-bounding areas within a primary bounding area. An aggregate traffic message includes traffic information aggregated from the sub-bounding areas and is broadcast throughout the primary bounding area.
Iheartmedia Management Services, Inc.

Dynamic image processing system

A dynamic image processing system including a hardware processor that extracts a heart region from a chest dynamic image which is obtained by radiation imaging of a dynamic state at a chest, extracts a density waveform for each pixel in the extracted heart region, determines an extraction target candidate region of blood flow information based on the extracted density waveform for each pixel, and sets an extraction target region of the blood flow information in the determined extraction target candidate region of the blood flow information.. .
Konica Minolta, Inc.

Machine learning system for assessing heart valves and surrounding cardiovascular tracts

A machine learning system for evaluating at least one characteristic of a heart valve, an inflow tract, an outflow tract or a combination thereof may include a training mode and a production mode. The training mode may be configured to train a computer and construct a transformation function to predict an unknown anatomical characteristic and/or an unknown physiological characteristic of a heart valve, inflow tract and/or outflow tract, using a known anatomical characteristic and/or a known physiological characteristic the heart valve, inflow tract and/or outflow tract.
Stenomics, Inc.

Machine-learning models for predicting decompensation risk

A method for determining a risk of decompensated heart failure in a user includes receiving a first set of data that is fixed with respect to time. A machine-learning model generates one or more initial risk factors based on the first set of data.
Microsoft Technology Licensing, Llc

Biomarkers to improve prediction of heart failure risk

The present disclosure relates to the field of laboratory diagnostics. Specifically, methods are disclosed for determining a patient's risk of suffering from heart failure (hf) based on the detection of nt-probnp, troponin t, and/or a natriuretic peptide.

Method of differentiating mesenchymal stem cells into cardiomyocytes

The present invention relates to a method of differentiating mesenchymal stem cells into cardiomyocytes. When the method of the present invention is used, cardiomyocytes may be obtained from mesenchymal stem cells with high efficiency.
Chonnam National University Hospital

Crystalline forms of trisodium supramolecular complex comprising valsartan and ahu-377 and methods thereof

Novel crystalline forms of trisodium [3-((1s,3r)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate-(s)-3′-methyl-2′-(pentanoyl{2″-(tetrazol-5-ylate)biphenyl-4′-ylmethyl}amino)butyrate] hydrate, methods for their preparation, pharmaceutical compositions comprising these new forms, and use of them for treating or delaying progression or onset of diseases or disorders related to activity of angiotensin receptor 1 (at1) blockage and neprilysin (nep) inhibition, such as heart failure, are disclosed.. .

Pacing site and configuration optimization using a combination of electrical and mechanical information

An apparatus comprises a cardiac signal sensing circuit configured to sense a plurality of intrinsic cardiac signals using a plurality of cardiac pacing sites, a heart sound sensing circuit, a stimulus circuit configured to provide an electrical cardiac pacing stimulus to the plurality of pacing sites, and a control circuit electrically coupled to the cardiac signal sensing circuit and the stimulus circuit. The control circuit includes a pacing site locating circuit configured to generate an indication of a preferred pacing site as one of a) a subset of the respective cardiac pacing sites selected using the intrinsic ventricular activation time interval value, from which subset the preferred pacing site is selected using the heart sound characteristic value; or b) a subset of the respective cardiac pacing sites selected using the heart sound characteristic value, from which subset the preferred pacing site is selected using the ventricular activation time interval value..
Cardiac Pacemakers, Inc.

Bifidobacteria for treating cardiac conditions

This invention relates to new uses of bifidobacteria (particularly, although not exclusively, probiotic bifidobacteria), and to food products, feed products, dietary supplements and pharmaceutical formulations containing them. The bacteria are suitable for the treatment of myocardial infarction, dilated cardiomyopathy, inflammatory heart disease (including endocarditis, inflammatory cardiomegaly and myocarditisl, and congestive heart failure..
Dupont Nutrition Biosciences Aps

Compositions for improving or maintaining myocardial function

Compositions comprising melatonin or derivatives thereof together with coenzyme q10 and/or alpha-lipoic are provided for oral administration to act as a cardioprotective treatment for heart failure, myocardial ischemia, cardiomyopathies, cardiotoxicity, and in relation to cardiac interventions.. .
Repoceuticals Aps

Systems, devices and methods for transcatheter valve delivery

A heart valve therapy system including a delivery device and a stented valve. The delivery device includes an outer sheath, an inner shaft, an optional hub assembly, and a plurality of tethers.
Medtronic Vascular Galway

Prosthetic heart valve and delivery apparatus

Embodiments of the present disclosure provide a prosthetic heart valve usable with a heart valve delivery apparatus for delivery of the prosthetic heart valve to a native valve site via the human vasculature. In one embodiment, a self-expanding valve comprises an expandable stent that is shaped to maintain the valve in the aortic annulus against axial without anchors or retaining devices that engage the surrounding tissue.
Edwards Lifesciences Corporation

Prosthetic heart valve and method

A system for replacing a deficient native aortic valve includes an implantable prosthetic valve having a self-expandable frame and a valve assembly formed with three valve leaflets. The self-expandable frame includes three angularly spaced longitudinal bars of fixed length defining respective slots and a plurality of web-like constructions extending between and connected to the longitudinal bars.
Edwards Lifesciences Pvt, Inc.

Prosthetic aortic heart valves

A prosthetic aortic valve includes an annular, annulus inflow portion that is designed to reside in or near the patient's native aortic valve annulus, and an annular, aortic outflow portion that is designed to reside in the patient's aorta downstream from at least a portion of the valsalva sinus. The annulus inflow portion and the aortic outflow portion are connected to one another by a plurality of connecting struts that are confined to regions near the commissures of the patient's native aortic valve.
St. Jude Medical, Llc

Bowed runners and corresponding valve assemblies for paravalvular leak protection

A prosthetic heart valve for replacing a native valve includes a stent extending between a proximal end and a distal end and including a plurality of struts forming cells, the stent having a collapsed condition and an expanded condition. At least one runner is coupled a cell, the at least one runner being configured to transition from a first configuration to a second configuration when the stent moves from the collapsed condition to the expanded condition, the at least one runner projecting radially outwardly from the cell in the second configuration.
St. Jude Medical, Cardiology Division, Inc.

Actively controllable stent, stent graft, heart valve and controlling same

A delivery apparatus can include a handle portion and at least one rotatable drive shaft. The handle portion can have an actuation mechanism with a motor.
Edwards Lifesciences Cardiaq Llc

Durable multi-layer high strength polymer composite suitable for implant and articles produced therefrom

A thin, biocompatible, high-strength, composite material is disclosed that is suitable for use in various implanted configurations. The composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as a prosthetic heart valve leaflet.
W. L. Gore & Associates, Inc.

Systems, methods and devices for delivery systems, methods and devices for implanting prosthetic heart valves

Embodiments of delivery systems, devices and methods for delivering a prosthetic heart valve device to a heart chamber for expanded implementation are disclosed. More specifically, methods, systems and devices are disclosed for delivering a self-expanding prosthetic mitral valve device to the left atrium, with no engagement of the left ventricle, the native mitral valve leaflets or the annular tissue downstream of the upper annular surface during delivery, and in some embodiments with no engagement of the ventricle, mitral valve leaflets and/or annular tissue located downstream of the upper annular surface by the delivered, positioned and expanded prosthetic mitral valve device..
4c Medical Technologies, Inc.

Enhancing efficiency of repeat ablation by merging current and previous maps

A method for cardiac treatment, which includes acquiring and saving an initial map of a chamber of a heart of a patient in an initial ablation procedure, with locations of ablation lesions marked on the initial map. In preparation for a redo ablation procedure, subsequent to the initial ablation procedure, a current map of the chamber is acquired, the initial map is registered with the current map, and the locations of the ablation lesions from the registered initial map are marked and displayed on the current map..
Biosense Webster (israel) Ltd.

Processing biological data

An apparatus for determining data pertaining to the heart rate, respiratory rate, and/or blood pressure of a human subject based on pulse waveform analysis is disclosed. The apparatus comprises a control unit and a sensor unit configured for providing pulse wave data representative of a heartbeat of a subject.
Preventicus Gmbh

Conformal sensor systems for sensing and analysis of cardiac activity

Systems, methods and apparatuses for monitoring cardiac activity of an individual using a conformal cardiac sensor device are presented herein. A conformal cardiac sensor device for analyzing cardiac activity includes a flexible substrate for coupling to the user, and a heart sensor component embedded on/in the substrate.
Mc10, Inc.

Body-worn sensor for characterizing patients with heart failure

The invention provides a sensor for measuring both impedance and ecg waveforms that is configured to be worn around a patient's neck. The sensor features 1) an ecg system that includes an analog ecg circuit, in electrical contact with at least two ecg electrodes, that generates an analog ecg waveform; and 2) an impedance system that includes an analog impedance circuit, in electrical contact with at least two (and typically four) impedance electrodes, that generates an analog impedance waveform.
Tosense, Inc.

Method of ecg evaluation based on universal scoring system

The invention is designed to diagnose cardiovascular system (cvs) based on at least 148 quantitative ecg parameters including heart rate variability (hrv) ones. Parameters are rated to 100 points, divided into 7 groups with close physiological nature, 4 diagnostic criteria (evaluation of cvs regulation, myocardium state, emotion state, hr disorders) and complex index of functional state (cifs) are calculated.

Mobile ecg sensor apparatus

Disclosed systems include mobile ecg sensors, systems and methods. Some embodiments provide ecg sensors in a credit card form factor that allows a user to contact two electrically isolated electrodes to measure heart electrical signals for a lead i ecg..
Alivecor, Inc.

System and camera-based heart rate tracking

A system and method for camera-based heart rate tracking. The method includes: determining bit values from a set of bitplanes in a captured image sequence that represent the hc changes; determining a facial blood flow data signal for each of a plurality of predetermined regions of interest (rois) of the subject captured by the images based on the hc changes; applying a band-pass filter of a passband approximating the heart rate to each of the blood flow data signals; applying a hilbert transform to each of the blood flow data signals; adjusting the blood flow data signals from revolving phase-angles into linear phase segments; determining an instantaneous heart rate for each the blood flow data signals; applying a weighting to each of the instantaneous heart rates; and averaging the weighted instantaneous heart rates..
Nuralogix Corporation

Physiological signal measurement device and blood oxygen concentration algorithm applied therein

A physiological signal measurement device includes a shell, a pair of induction sheets mounted to the shell, and a circuit board assembly mounted in the shell. The circuit board assembly includes a microprocessor, a photoplethysmography sensor electrically connected with the microprocessor, and an electrocardio signal sensor.
Cheng Uei Precision Industry Co., Ltd.

Mesh transceiver for in-band on-channel broadcasting (iboc) mesh network

Digital content can be broadcast in a sideband of an analog broadcast channel using multiple digital in-band on-channel (iboc) transceivers connected in a mesh configuration to form an iboc mesh network. The digital iboc transceivers are positioned at various geographic locations, so that unlike traditional “hd” radio broadcasts, the iboc broadcast transmission is spread out over a wide area, using multiple low power digital iboc transceivers rather than being broadcast from the same location as the analog signal.
Iheartmedia Management Services, Inc.

Distributed database for synchronizing the accessibility of nodes and shared devices

A technique for an access node to synchronize the accessibility of a plurality of access nodes within a network is described. The technique receives an accessibility update and/or device update from a remote node.
Wigwag, Inc.

Vehicular personnel accountability & safety system

A system and method for monitoring fleets of vehicles and vehicle operators is disclosed. A vehicle is installed with device(s) collecting positional data such as vehicle movement and orientation with respect to other vehicles and road hazards.
Lifepass Inc.

Biomarkers for prediction of development of hypoxemia due to acute lung injury

The present invention relates to a set of biomarkers, which can be used to determine the risk of developing hypoxemia for subjects undergoing open heart surgery with the use of cardiopulmonary bypass (cpb).. .
Aalborg Universitet

Channel type induction furnace

Disclosed is a channel type induction furnace (50) provided with a furnace floor (71) that is inclined downwards from an operative rear of the furnace hearth (50) towards an opposing operative front of the hearth (50), with a wall (73a) at the front of hearth (50) comprising a bottom section (76) and a top section (77), with the front wall bottom section (76) extending further into the hearth (50) than the front wall top section (77), and the front wall bottom section (76) terminating in an upper edge (78) in abutment with the front wall top section (77), with a down-passage (9) to an induction heater (79), located proximate the front wall (73a), having an inlet in the floor (71) at a location proximate the base of the front wall (73a) and the or each up-passage (54a, 54b) having an outlet in the floor (71) at a location in abutment with the base of the front wall bottom section (76) and with the front wall bottom section (76) being provided with a vertical slot (59a, 59b) extending upwards above the or each up-passage (54a, 54b) through it and opening onto the upper edge (78) of the bottom section (76).. .
Envirosteel Inc.

Devices and systems for accessing cardiac tissue

Devices, systems, and methods for accessing the internal and external tissues of the heart are disclosed. At least some of the embodiments disclosed herein provide access to the external surface of the heart through the pericardial space for localized delivery of substances to the heart tissue.
Cvdevices, Llc

Steering engagement catheter devices, systems, and methods

Steering engagement catheter devices, systems, and methods of using the same for accessing a tissue, including internal and external tissues of a heart, are disclosed. In at least one embodiment, a steering engagement catheter is provided, comprising an elongated tube having a proximal end, a distal end, and a first wall positioned circumferentially along a length of the elongated tube, the elongated tube configured such that a delivery catheter is capable of at least partial insertion into the elongated tube, at least one steering wire having a proximal end and a distal end, the distal end of the at least one steering wire coupled to the first wall of the elongated tube at or near the distal end of the elongated tube, and a controller operably coupled to the at least one steering wire at or near the proximal end of the at least one steering wire..
Cvdevices, Llc

System and communication with an infusion device

It may desirable to monitor or control a pump remotely. For example, the pump may be positioned near the patient, with remote control or monitoring of the pump occurring in a control room.
Iradimed Corporation

Implantable intravascular ventricular assist device

The present disclosure provides intravascular ventricular assist devices for insertion into the vasculature of an individual to improve the overall blood flow of the individual. In many embodiments, the intravascular ventricular assist devices described herein provide an individual with an intravascular ventricular assist device that is sized and configured for insertion into an aortic root or pulmonary root such that its reduced size and placement provide the individual with an improved quality of life.

Redundant-impeller artificial heart

An artificial heart for use in a human recipient includes a housing within which a quartet of turbine pump segments are operative. The quartet of turbine pump segments is configured to provide a pair of redundant input and output turbine pump segment pairs each input and output pair being coupled by a curved passage providing a redundancy which, in turn, enhances the safety factor provided by the artificial heart.

Location, time, and/or pressure determining devices, systems, and methods for deployment of lesion-excluding heart implants for treatment of cardiac heart failure and other disease states

Devices, systems, and methods for treating a heart of a patient may make use of structures which limit a size of a chamber of the heart, such as by deploying one or more tensile member to bring a wall of the heart and a septum of the heart into contact. A plurality of tension members may help exclude scar tissue and provide a more effective remaining ventricle chamber.
Bioventrix, Inc.

Self-expanding heart assist device

The present invention includes a device and method for a self-expanding framework device adapted to facilitate the deployment of an extra-cardiac device. The device includes a deployment tube and a self-expanding wire framework having a structure that results in the self-expanding wire framework circumferential flaring motion and bending outwardly to advance around the heart..
Corinnova Incorporated

Transcatheter atrio-ventricular valve prosthesis

A transcatheter atrio-ventricular valve prosthesis for functional replacement of an atrio-ventricular valve in a connection channel, having a circumferential connection channel wall structure, between atrial and ventricular chambers of a heart, including an inner device to be disposed in the interior of the connection channel, the inner device having a circumferential support structure which is radially expandable and having a valve attached to the circumferential support structure, and an outer device to be disposed on the exterior of the connection channel, wherein the outer device at least partly extends around the inner device at a radial distance to the inner device, wherein the inner and outer devices form a securing mechanism for securing the circumferential connection channel wall structure therebetween.. .
Highlife Sas

Coiled anchor for supporting prosthetic heart valve, prosthetic heart valve, and deployment device

A system including an anchor for docking a prosthetic valve at a native valve of a heart can have a first end, a second end, and a central axis extending between the first and second ends, and defines an inner space coaxial with the central axis. The valve prosthesis can include a protective layer or annular ring that surrounds a bottom edge of the second frame end.
Mitral Valve Technologies Sarl

Multi-component designs for heart valve retrieval device, sealing structures and stent assembly

This invention relates to the design and function of a device which allows for retrieval of a previously implanted valve prosthesis from a beating heart without extracorporeal circulation using a transcatheter retrieval system, including a guide component to facilitate the compression of the valve and retraction into a retrieval catheter, as well as an improved prosthetic transcatheter heart valve having one or more of: a series of radially extending tines having a loop terminus to improve sealing a deployed prosthetic mitral valve against hemodynamic leaking, a pre-compressible stent-in-stent design, or an articulating cuff attached to a covered stent-valve and a commissural sealing skirt structure attached to the underside of the articulating cuff.. .
Tendyne Holdings, Inc.

Embolic protection during percutaneous heart valve replacement and similar procedures

Various devices are described to provide filtering of flow from the aorta to the left carotid artery and the right carotid artery. The filters can be brought into a desired position through one or more peripheral arteries.
Lumen Biomedical, Inc.

Methods and atrioventricular valve repair

Methods and devices are disclosed for minimally invasive procedures in the heart. In one application, a catheter is advanced from the left atrium through the mitral valve and along the left ventricular outflow tract to orient and stabilize the catheter and enable a procedure such as a “bow tie” repair of the mitral valve.
Cedars-sinai Medical Center

Sensor guided catheter navigation system

A method and a system for producing images of a subject, such as the heart of a human being. The method may comprise acquiring ultrasound images of the subject with a catheter comprising a position sensor.
Carnegie Mellon University

Ultrasound automatic determination of heart chamber characteristics

Ultrasound systems and methods for automatically determining heart chamber characteristics are provided. The systems and methods of the present invention, for example, can automatically determine chamber pressures and volumes of a patient's heart using a transthoracic or transesophageal ultrasound probe imaging the heart in 2d and/or 3d.
Koninklijke Philips N.v.

Wearable fetal monitoring system having textile electrodes

A seamless, smart fetal monitoring garment and methods of using thereof. The system includes a knitted or interwoven garment having a multiplicity of conductive textile electrodes for sensing maternal and fetal electrical vital signals.
Healthwatch Ltd.

Pain management based on respiration-mediated heart rates

This document discusses, among other things, systems and methods for managing pain of a subject. A system may include a sensor circuit configured to sense a respiration signal and a heart rate signal.
Boston Scientific Neuromodulation Corporation

Portable device and physical strength evaluation method thereof

A physical strength evaluation method of a portable device is disclosed. The physical strength evaluation method of the portable device comprises the steps of: measuring a walking speed of a user; measuring the heart rate of the user; and evaluating the physical strength of the user by using the measured heart rate when the walking speed of the user changes to a specific speed or higher..
Lg Electronics Inc.

Athletic performance monitoring system utilizing heart rate information

Athletic activity may be monitored using heart rate in addition to or instead of other types of metrics. Accordingly, multiple different activity types may be compared based on heart rate information.
Nike, Inc.

Atrial fibrillation discrimination using heart rate clustering

This document discusses, among other things, apparatus, systems, and methods to determine a first atrial fibrillation (af) indication using received information about a heart over a first period, to cluster depolarization information about the heart over the first period, and to discriminate between an atrial fibrillation (af) event and a non-af event in the first period using the determined first af indication the clustered depolarization information.. .
Cardiac Pacemakers, Inc.

System and physiological parameter monitoring

The present disclosure relates to a device, method and system (100) for calculating, estimating, or monitoring the physiological parameters of a subject. At least one processor, when executing instructions, may perform one or more of the following operations: receiving a first signal representing a pulse wave relating to heart activity of a subject, receiving a plurality of second signals representing time-varying information on the pulse wave, determining a blood oxygen level of the subject based on the plurality of second signals, identifying a first feature in the first signal, identifying a second feature in one of the plurality of second signals, computing a pulse transit time based on a difference between the first feature and the second feature, calculating a blood pressure of the subject based on the pulse transit time..
Vita-course Technologies Co., Ltd.

Novel optical interferometric scanning detector for cardiovascular function monitoring

The object of the present invention is to disclose a novel optical miniaturized handheld medical device for convenient monitoring and/or data collection of detailed signals on human cardiovascular function. The implementation consists of a number of advanced technologies, including interferometric detection, phase controlled focusing beam steering, auto-tracking scheme and algorism, and integrated optical chip assembly to enhance the device's performance and miniaturization.
Omnisensing Photonics, Llc

Risk stratification based heart failure detection algorithm

A system comprises a risk analysis module and a worsening heart failure (whf) detection module. The risk analysis module measures at least one first physiological parameter of a subject using a physiological sensor of an ambulatory medical device, and determines a heart failure (hf) risk score for the subject according to the at least one measured first physiological parameter.
Cardiac Pacemakers, Inc.

Blood pressure and cardiac monitoring system and method thereof

A blood pressure and cardiac monitoring system includes a sensing assembly, processor, memory, communication interface, and any suitable computer implemented modules communicatively coupled to each other via a bus. The sensing assembly comprises a first, second, and third sensor.
Robert Bosch Gmbh

Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion

A solution comprises a preservation mixture comprising a calcium ion source; and a buffer for maintaining a ph of the solution. The molar concentration of calcium ion (ca2+) in the solution is from 0.18 to 0.26 mmol/l, and the ph is lower than 7.4 and higher than 6.6.

Blood treatment machine having electrical heartbeat analysis

A blood treatment machine includes a blood pump; an arterial line in fluid communication with the blood pump; a venous line; and a heartbeat evaluation system including (i) a first electrode coupled to the arterial line or to a patient, (ii) a second electrode coupled to the venous line, (iii) electronic circuitry communicating electrically with the first electrode and the second electrode to sense an electrical heartbeat signal generated by the patient, and (iv) signal processing configured to use the sensed heartbeat signal to calculate at least one of (a) heart rate, (b) respiration, (c) stroke volume, (d) cardiac output, or (e) central blood volume.. .
Suntory Flowers Limited

. .

Intrusion detection using a heartbeat

A variety of techniques are disclosed for detection of advanced persistent threats and similar malware. In one aspect, the detection of certain network traffic at a gateway is used to trigger a query of an originating endpoint, which can use internal logs to identify a local process that is sourcing the network traffic.
Sophos Limited

Privacy-protecting wireless medical devices

Systems and methods are provided for protecting the privacy of wireless enabled medical device (wemd) communications, particularly against traffic-analysis attacks. In an exemplary method, a wemd measures a physiological parameter and conveys that physiological parameter to a wemd-receiver using messages that simulate at least one message from a cover device, for example by embedding physiological data in a message from a simulated cover device.
Pcms Holdings, Inc.

Cardiovascular risk event prediction and uses thereof

Methods and computer methods used to assess an individual for the prediction of risk of developing a cardiovascular (cv) event over a 1 to 5 year period are provided. The methods employ at least two biomarkers selected from mmp12, angiopoietin-2, complement c7, cardiac troponin i, angiopoietin-related protein 4, ccl18/parc, alpha-1-antichymotrypsin complex, gdf11 and alpha-2-antiplasmin, or gdf11 in combination with fstl3.
Somalogic, Inc.

Boiler ash remover based on combined flow

A boiler ash remover based on a combined flow includes a frequency-adjustable acoustic flow generator, a fixing bracket, a compressed air source, a three-way air-source electric-control valve, an air jet generator, an acoustic-jet combined transmission tube, an acoustic jet intelligent control system, and a scale measurement and control sensor. The compressed air source is connected to an inlet end of the three-way air-source electric-control valve.
Nanjing Changrong Acoustic Inc.

Kind of led light

The present invention is intended to provide a led light that could display brilliant heart shape rainbow-like lighting effects and offer flexible casing structure for easily extending the hardware capability. It has case and circuit board.

Markers to predict macrocyclic lactone drug resistance in dirofilaria immitis, the causative agent of heartworm disease

Disclosed are nucleic acid molecules from the genome of dirofilaria spp. Nematodes that contain single nucleotide polymorphisms related to reduced responsiveness of the nematodes to macrocyclic lactones.
Mcgill University

Treatments for gastrointestinal disorders

The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (ibs), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (gerd), duodenogastric reflux, crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein. Using peptides and other agents that activate the guanylate cyclase c (gc-c) receptor..
Ironwood Pharmaceuticals, Inc.

G protein-coupled receptor kinase inhibitors and methods for use of the same

Disclosed herein are novel grk inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of formula (i) and pharmaceutically acceptable salt thereof, wherein the substituents are as described..
The Regents Of The University Of Michigan

Using emotional maps and dialog display technology to improve workout experiences

Systems, apparatuses and methods may provide for technology to improve a workout experience of a user by determining an emotional state of the user, identifying a workout route based on the emotional state of the user, and outputting the workout route via a user interface device. Additionally, determining the emotional state of the user may include inferring emotions from one or more sensor information or user speech information.
Intel Corporation

Methods and systems for controlling blood pressure by controlling atrial pressure

Systems and methods for controlling blood pressure by controlling atrial pressure and atrial stretch are disclosed. In some embodiments, a stimulation circuit may be configured to deliver a stimulation pulse to at least one cardiac chamber of a heart of a patient, and at least one controller may be configured to execute delivery of one or more stimulation patterns of stimulation pulses to the at least one cardiac chamber, wherein at least one of the stimulation pulses stimulates the heart such that an atrial pressure resulting from atrial contraction of an atrium overlaps in time a passive pressure build-up of the atrium, such that an atrial pressure of the atrium resulting from the stimulation is a combination of the atrial pressure resulting from atrial contraction and the passive pressure build-up and is higher than an atrial pressure of the atrium would be without the stimulation, and such that the blood pressure of the patient is reduced..
Backbeat Medical, Inc.

Detecting and responding to anti-tachyarrhythmia shocks

In some examples, an implantable medical device determines that another medical device delivered an anti-tachyarrhythmia shock, and delivers post-shock pacing in response to the determination. The implantable medical device may be configured to both detect the delivery of the shock in a sensed electrical signal and, if delivery of the shock is not detected, determine that the shock was delivered based on detection of asystole of the heart.
Medtronic, Inc.

Autonomous implantable capsule for heart stimulation

The implant including an elongated tubular body, having at a first end a releasable device connected to an installation lead, and at a second end a member for anchoring to a heart wall, the tubular body housing a frame supporting an electronic unit. The implant further comprises an accelerometer.
Sorin Crm Sas

Assessment of coronary heart disease with carbon dioxide

The invention provides methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising co2 to a subject to reach a predetermined paco2 in the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. The invention also provides methods for increasing sensitivity and specificity of bold mri..
Cedars-sinai Medical Center

Use of pde iii inhibitors for the reduction of heart size in mammals suffering from heart disease

A phosphodiesterase type iii (pde iii) inhibitor or ca2+-sensitizing agent or a pharmaceutically acceptable derivative thereof is provided for the preparation of a medication for the reduction of the heart size of a patient suffering from heart failure.. .
Boehringer Ingelheim Vetmedica Gmbh

Heart valve coaptation device

In one embodiment, a leaflet capture device for improving the coaptation of heart valve leaflets is provided. The leaflet capture device can include a first clip portion having inner and outer portions.
Edwards Lifesciences Corporation

Prosthetic heart valve deployment systems

A quick-connect heart valve prosthesis that can be quickly and easily implanted is provided. The heart valve includes a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable coupling stent, thereby enabling attachment to the annulus without sutures.
Edwards Lifesciences Corporation

Inflatable device for improving physiological cardiac flow

An implant system for improving physiological cardiac flow in a human heart is provided including an inflatable implant for positioning at least partially within an atrium, a ventricle and a atrial/ventricular valve of the human heart and defining a surface for intercepting and redirecting hemodynamic flow into the ventricle, the inflatable implant defining a surface to engage the valve; a therapeutic apical base plate assembly attachable to the apex of the heart; and a tether connected between the inflatable implant and the therapeutic apical base plate assembly. The inflatable implant and the therapeutic apical base plate assembly are configured to reshape the ventricular wall by transducting cardiac force and/or energy generated by the heart during systole and diastole when the inflatable implant is engaged with the valve and of the therapeutic apical base plate assembly is attached to the apex..
Harmony Development Group, Inc.

Lifetime regenerative heart valve

A replacement valve for replacing a damaged heart valve having a plurality of cusps separating an upstream region from a downstream region of a passage. The replacement valve includes a flexible band having biocompatible scaffolding sized for contact with a wall surrounding the passage in the patient's heart.

Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets

A transcatheter, percutaneously implantable, prosthetic heart valve is provided that comprises a lattice frame and two or more integrated cusp and leaflet folded structures attached to the lattice frame. The two or more integrated cusp and leaflet folded structures each comprise a flat sheet of biocompatible membrane that is folded to include a substantially conical shape according to a flat folding pattern.
Colibri Heart Valve Llc

Expandable device for capturing regurgitant jet, volume, and force to effect ventricular function and remodeling

An implant system for capturing a regurgitant jet to effect preserving the atrioventricular pressure gradient and ventricular remodeling in a human heart including an expandable implant for positioning in the atrial/ventricular valve of the human heart and at least partially within the atrium and/or the ventricle, the expandable implant defining a first position for at least partially capturing the atrioventricular pressure gradient and regurgitant trans-valvular blood flow and associated driving forces during systole and a second position for steering flow from the atrium to the ventricle to enhance vorticular flow during diastole; a therapeutic apical base plate attachable to the apex of the heart; and a tethering conduit connected between the expandable implant and the therapeutic apical base plate assembly that transducts the energy and/or forces of captured regurgitant trans-valvular blood flow or atrioventricular pressure to the structures of the ventricle and the ventricular wall.. .
Harmony Development Group, Inc.

Drug delivery systems and methods

Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (csf) pulsation or the patient's heart or respiration rate).
Alcyone Lifesciences, Inc.

Method and system for assessing mental state

A computer-implemented method of assessing a mental state of a subject (106) includes receiving (302), as input, a heartbeat record (200) of the subject. The heartbeat record comprises a sequence of heartbeat data samples obtained over a time span which includes a pre-sleep period (208), a sleep period (209) having a sleep onset time (224) and a sleep conclusion time (226), and a post-sleep period (210).
Medibio Limited

Method and system for monitoring stress conditions

A computer-implemented method of assessing a stress condition of a subject (106) includes receiving (302), as input, a heartbeat record (200) of the subject. The heartbeat record comprises a sequence of heartbeat data samples obtained over a time span which includes a pre-sleep period (208), a sleep period (209) having a sleep onset time (224) and a sleep conclusion time (226), and a post-sleep period (210).
Medibio Limited

Automated ecg analysis and diagnosis system

An ecg system identifies and annotates cardiac electrophysiological signals in an ecg waveform from harmonic waveforms. Electrical impulses are received from a beating heart.

Reconstructing current dipole sources from magnetic field data on one plane

In embodiments, reconstruction of current dipole sources is accomplished by calculating the positions of the possible current dipoles in the heart with respect to the measured data plane and by converting a set of non linear equations to a set of linear equations.. .

Real-time heart rate detection method and real-time heart rate detection system therefor

A real-time heart rate detection method for use in a real-time heart rate detection system includes: (a) emitting light to a finger to generate reflected light; (b) receiving the reflected light via a sensing unit, to generate at least one initial fingerprint image; (c) generating plural initial waveform information according to the at least one initial fingerprint image; (d) selecting one among plural different bandpass filters, to filter the initial waveform information; (e) calculating an initial heart rate based upon the filtered initial waveform information; (f) checking and computing a frequency range of the obtained initial heart rate, to determine which one of the plural bandpass filters is the most preferable bandpass filter; (g) outputting a final heart rate; and repeating the step (a) to the step (g). The step (g) and the step (f) are performed at least partially in parallel..
Eosmem Corporation

Non-invasive measuring sound frequencies created by vortices in a carotid artery

A method for measuring sound from vortices in the carotid artery comprising: first and second quality control provisions, wherein the quality control compares detected sounds to pre-determined sounds, and upon confirmation of the quality control procedures, detecting sounds generated by the heart and sounds from vortices in the carotid artery for at least 30 seconds.. .
Cvr Global Inc.

Bio-sensing glasses to detect cardiovascular disease

Bio-sensing devices are embedded as part of smart eye-wear system, comprising of a pair of temples and a nose pad. A plurality of sensors disposed within the eye-glasses and are adapted to acquire, analyze, and classify biometric information to monitor and detect abnormal heart behavior and to predict congestive heart failure.
Awaire Inc.

Alarm system that processes both motion and vital signs using specific heuristic rules and thresholds

The invention provides a body-worn monitor that measures a patient's vital signs (e.g. Blood pressure, spo2, heart rate, respiratory rate, and temperature) while simultaneously characterizing their activity state (e.g.
Sotera Wireless, Inc.

Novel uses

The invention relates to the administration of inhibitors of phosphodiesterase 1 (pde1) for the treatment of diseases or disorders characterized by disruption of or damage to various cgmp/pkg mediated pathways. In one embodiment the invention relates to inhibitors of phosphodiesterase 1 (pde1) for treatment of cardiovascular disease and related disorders, e.g., congestive heart disease, atherosclerosis, myocardial infarction, and stroke..
Sunglory Beheer B.v.

Fast rendering of quadrics and marking of silhouettes thereof

Described embodiments include an apparatus that includes a display, including a screen, and a processor. The processor is configured to define a bounding region on the screen.
Biosense Webster (israel) Ltd.

Fast rendering of quadrics

Described embodiments include an apparatus that includes a display, including a screen, and a processor. The processor is configured to define a bounding region on the screen.
Biosense Webster (israel) Ltd.

Heart rate activity detecting system based on dynamic images and method thereof

Provided is a heart rate activity detecting method based on dynamic images. The method includes tracking a moving object.
Industrial Technology Research Institute

Cardiac stem cells and methods of identifying and using the same

Methods of isolating cardiac cells, including cardiac cells capable of regenerating cardiac tissue are provided. Compositions comprising cardiac cells, including cardiac cells capable of regenerating cardiac tissue are also provided.
Vestion, Inc.

Hearth oven

An oven is provided. The oven includes a housing comprising a baking surface and an enclosure.
Jade Range Llc

Rkip agonism in the treatment and prevention of heart failure

The present invention relates to a pharmaceutical composition comprising raf kinase inhibitor protein (rkip), or a fragment or a variant thereof; or an rkip agonist for use in the treatment or prophylaxis of a low transvalvular pressure gradient (pmean) in a patient. The present invention further relates to a method of treatment of a patient in need thereof, said method comprising administering to said patient a medically active amount of a compound selected from the group consisting of: a raf kinase inhibitor protein (rkip) or a functional fragment or a functional variant thereof; and a rkip agonist, wherein said patient suffers from or is likely to suffer from a low transvalvular pressure gradient (pmean).
Leibniz-institut Für Analytische Wissenschaften- Isas-e.v.

Forehearth frits, pearls and/or concentrates for fluorescence

The present invention relates to the field of forehearth fits, pearls, and/or concentrates for use in glass compositions. In particular, the present invention provides a system of forehearth frits, pearls, and/or concentrates that is capable of parting a fluorescent effect to a glass composition by adding a fluorescent glass fit, pearl or concentrate in the forehearth of a glass furnace, to form fluorescent glass and a method of using the fluorescent system of forehearth fits, pearls, and/or concentrates..
Ferro Corporation

Fixation methods for leadless cardiac devices

An implantable leadless pacing device may comprise a power source and circuitry operatively coupled to the power source. The circuitry configured to pace a patient's heart and/or sense electrical activity of the patient's heart.
Cardiac Pacemakers, Inc.

Internal thoracic vein placement of a transmitter electrode for leadless stimulation of the heart

Implantable medical device systems and methods of use including an implantable first medical device having a lead with a transducer thereon and an implantable second medical device having a receiver for receiving energy emitted by the transducer. The lead may be placed in an internal thoracic vein, and other locations may be used as well.
Cardiac Pacemakers, Inc.

Delivery devices and methods for leadless cardiac devices

Delivery devices, systems, and methods for delivering implantable leadless pacing devices are disclosed. An example delivery device may include a tubular member and a distal holding section extending distally of a distal end of the tubular member and defining a cavity therein for receiving an implantable leadless pacing device.
Cardiac Pacemakers, Inc.

Treatment of cardiac disorders by blocking sk4 potassium channel

Methods of inducing bradycardia (slowing a heart rate) in a subject in need thereof, treating a medical condition in which inducing bradycardia (slowing a heart rate) is desirable or beneficial in a subject in need thereof and/or treating a medical condition associated with cardiac arrhythmia, are provided. The methods are effected by blocking sk4 channel in san cell of the subject and/or by administering to the subject a therapeutically effective amount of a blocker of an sk4 channel.
Ramot At Tel-aviv University Ltd.

Prosthetic mitral valve

A prosthetic heart valve having an inflow end and an outflow end includes a stent having a collapsed condition, an expanded condition, and a plurality of cells arranged in circumferential rows. The stent may include one or more securement features.
St. Jude Medical, Cardiology Division, Inc.

Heart valve docking devices and systems

Docking devices for docking a prosthetic valve at a native valve of a heart can include a coiled docking anchor and a retrieval suture. The docking device and retrieval suture can be configured for improved retention and retrieval of the docking device after deployment.
Edwards Lifesciences Corporation

Low-profile heart valve and delivery system

Disclosed replacement heart valves can be designed to be delivered to a native valve site while crimped on a delivery catheter. The crimped profile of the replacement valve can be minimized by, for example, separating a frame or stent structure from a leaflet structure, along the axial direction.
Edwards Lifesciences Corporation

Implantable device for improving or remedying valvular incompetence

An implantable device for improving or remedying valvular incompetence, comprising a sealing body and at least one anchoring element (2) fastened thereto, by means of which the sealing body is able to be fastened in the heart, preferably in the atrium of the heart, wherein the sealing body comprises at least one cavity (6), which is also able to be filled with a fluid after implanting the sealing body and preferably not able to be emptied independently, and wherein, furthermore preferably, the sealing body remains expanded with constant volume during the cardiac phases as a result of the filling, characterized in that a plurality of cavities (6) are disposed about a main body (1) of the sealing body lying in the direction of longitudinal extent of the sealing body, or a single cavity (6) surrounds a main body (1) of the sealing body lying in the direction of longitudinal extent of the sealing body, wherein the main body (1) is embodied as a tube which is able to be bent out of the linear extent thereof and into the lateral surface of which a multiplicity of cuts have been introduced.. .
Coramaze Technologies Gmbh

Intravascular blood filter

Disclosed is a novel filter and delivery means. The device described within will not interfere with standard practice and tools used during standard surgical procedures and tools such as cannulas, clamps or dissection instruments including valve replacement sizing gages or other surgical procedures where the patient must be put on a heart-lung machine cross-clamping the aorta..
Claret Medical, Inc.

Method and catheter for creating an interatrial aperture

A catheter device 10 with a cutting structure or means 16 on the distal portion 14 is disclosed, along with a medical procedure for using the device. The catheter 10 is configured in such a way as to create a permanent interatrial aperture in the heart, including creating a permanent interatrial hole and/or removing tissue..
Intershunt Technologies, Inc.

Implantable devices and related methods for heart failure monitoring

Implantable devices for continuously monitoring vascular lumen dimensions, in particular in the inferior vena cava (ivc) for determining heart failure status of a patient. Related therapy systems as well as monitoring and therapy methods are also disclosed.
Foundry Innovation & Research 1, Ltd.

Systems, environment and methods for identification and analysis of recurring transitory physiological states and events using a portable data collection device

In one aspect, the systems, environment, and methods described herein support anticipation and identification of adverse health events and/or atypical behavioral episodes such as autistic behaviors, epileptic seizures, heart attack, stroke, and/or narcoleptic “sleep attacks” using a portable data collection device. In another aspect, the systems, environment, and methods described herein support measurement of motions and vibrations associated with recurring transitory physiological states and events using a portable data collection device.

Method and device for presenting st event in electrocardiogram

A method for presenting an st event in an electrocardiogram (ecg) comprises: drawing an amplitude trend graph of an st segment in the ecg; detecting an st event in the amplitude trend graph of the st segment; and marking the detected st event in the amplitude trend graph of the st segment. In the present invention, the st event is automatically detected and marked in the amplitude trend graph of the st segment, so that the st events are presented more intuitively, and the user can intuitively and quickly locate the st event in the amplitude trend graph of the st segment and quickly know a raised or depressed situation of the st event; the time of subsequent analysis and summary can be effectively reduced, and a blood supply state of the heart of the subject can be timely and quickly known..
Edan Instruments, Inc.

In-canal heart rate monitoring apparatus

A wearable computing device includes one or more processors, memory and a physiological metric sensor system, including a light source configured to direct light into tissue of a user wearing the wearable computing device, a light detector implemented a distance away from the light source and configured to detect light from the light source that reflects back from the user, and a light-blocking portion implemented between the light source and the light detector. The wearable computing device may further include an audio port directed towards an ear canal of the user and control circuitry configured to activate the light source during a period of time and generate a light detector signal indicating an amount of light detected by the light detector during the period of time..
Fitbit, Inc.

Cardiovascular disease detection

Methods and systems for detecting a heart condition include measuring a user's heart beat information. A predictive model is applied that includes multiple individual predictors and a classifier.

Humanized heart muscle

Described herein is a method for producing a chimeric non-human animal expressing a human nkx2-5, handii, tbx5 gene or a combination thereof gene comprising: a) generating a nkx2-5, handii, tbx5 or combination thereof null non-human animal cell, wherein both copies of the non-human nkx2-5, handii, tbx5 gene or combination thereof carry a mutation that prevents production of functional nkx2-5, handii, tbx5 protein or combination thereof in said non-human animal; b) creating a nkx2-5, handii, tbx5 or combination thereof null non-human blastocyst by somatic cell nuclear transfer comprising fusing a nucleus from said nkx2-5, handii, tbx5 or combination thereof null non-human animal cell of a) into an enucleated non-human oocyte and activating said oocyte to divide so as to form an nkx2-5, handii, tbx5 or combination thereof null non-human blastocyst; c) introducing human stem cells into the nkx2-5, handii, tbx5 or combination null non-human blastocyst of b); and d) implanting said blastocyst from c) into a pseudopregnant surrogate non-human animal to generate a chimeric non-human animal expressing human nkx2-5, handii, tbx5 or combination thereof.. .
Regents Of The University Of Minnesota

Sound collector, animal emotion estimation device, and animal emotion estimation method

An animal emotion estimation device includes: a sound collector configured by an elastic member having a recess, a sound concentrating microphone provided on the bottom portion of the recess, and an impact absorber covering the entire of the elastic member and the sound concentrating microphone; a harness to mount the sound collector on an animal; a converter that filters and converts the sound collected through the sound collector into a heart rate signal; an estimation portion that estimates the emotion of the animal based on the heart rate signal; and an output unit that supplies information showing the estimation estimated by the estimation portion.. .
Inupathy Inc.

A method and an determining training status

A method and apparatus for determining training status from a group of alternatives from a plurality of exercises, where a user has frequently monitored exercises with at least heart rate being measured by a host process, which outputs selected variables for calculating the training status by a child process.. .
Firstbeat Technologies Oy

Method and process for providing a subject-specific computational model used for treatment of cardiovascular diseases

A subject-specific simulation model of at least one component in the cardiovascular system for simulating blood flow and/or structural features. This simulation model can be used as a tool for cardiovascular diagnostic and/or treatment planning.
Sintef Tto As

System and semantic differentiation of individuals based on electronic medical records

This document presents a system and method to extract highly meaningful terms from unstructured fields in an emr that distinguish two different patient populations. Using this system, healthcare providers can quickly identify terms that are highly associated with a specific set of patients, for instance, chronic heart failure (chf) patients who are high utilizers of the emergency department (ed) compared to chf patients with low ed utilization.

Crystal of 5-hydroxy-4-(trifluoromethyl)pyrazolopyridine derivative

A crystal of a compound represented by the general formula (i) or a pharmacologically acceptable salt thereof has an excellent lcat-activating effect and is useful as an active ingredient in a therapeutic or prophylactic agent for arteriosclerosis, arteriosclerotic heart disease, coronary heart disease (including heart failure, myocardial infarction, angina pectoris, cardiac ischemia, cardiovascular disturbance, and restenosis caused by angiogenesis), cerebrovascular disease (including stroke and cerebral infarction), peripheral vascular disease (including diabetic vascular complications), dyslipidemia, hypo-hdl-cholesterolemia, or renal disease, particularly, an anti-arteriosclerotic agent, wherein r1 is a hydrogen atom or a hydroxy group, and r is a 2-(trifluoromethyl)pyrimidin-5-yl group or a 5-(trifluoromethyl)pyrazin-2-yl group.. .
Daiichi Sankyo Company, Limited

Process of using a submerged combustion melter to produce hollow glass fiber or solid glass fiber having entrained bubbles, and burners and systems to make such fibers

Processes and systems for producing glass fibers having regions devoid of glass using submerged combustion melters, including feeding a vitrifiable feed material into a feed inlet of a melting zone of a melter vessel, and heating the vitrifiable material with at least one burner directing combustion products of an oxidant and a first fuel into the melting zone under a level of the molten material in the zone. One or more of the burners is configured to impart heat and turbulence to the molten material, producing a turbulent molten material comprising a plurality of bubbles suspended in the molten material, the bubbles comprising at least some of the combustion products, and optionally other gas species introduced by the burners.
Johns Manville

Process for producing metals and metal alloys using mixing cold hearth

A metallurgical system for producing metals and metal alloys includes a fluid cooled mixing cold hearth having a melting cavity configured to hold a raw material for melting into a molten metal, and a mechanical drive configured to mount and move the mixing cold hearth for mixing the raw material. The system also includes a heat source configured to heat the raw material in the melting cavity, and a heat removal system configured to provide adjustable insulation for the molten metal.
Molyworks Materials Corp.

Positive pressure pulses cardio-pulmonary resuscitation device

A cardiopulmonary resuscitation, cpr, device (100, 200, 400) for delivering intrathoracic pressure pulses to a subject (290), the device comprising an air pressure generator (110, 310, 410) for delivering air to the airways of the subject (290), wherein the air pressure generator (110, 310, 410) is configured to: operate a first mode, wherein in the first mode the air pressure generator (110, 310, 410) generates a first output (412, 770a, 770b) comprising a first plurality of positive pressure pulses (771) for temporally increasing the subject's intrathoracic pressure to induce compressions of the heart of the subject (290) by increasing the volume of the subject's lungs; operate a second mode, wherein in the second mode the air pressure generator (110, 310, 410) generates a second output (414, 880) comprising a second plurality of positive pressure pulses for providing an assured airflow to the lungs of the subject (290); and deliver a resulting output (425, 986, 1086) to the airways of the subject (290), the resulting output being the superposition of the first output (412, 770a, 770b) and of the second output (414, 880); wherein said first plurality of positive pressure pulses (771) have an amplitude greater than 30 mbar and a frequency in a range of 40-240 beats per minute; and wherein said second plurality of positive pressure pulses have an amplitude smaller than 30 mbar and a frequency in a range of 3 to 20 cycles per minute.. .
Koninklijke Philips N.v.

Apparatus for performing peritoneal ultrafiltration

An apparatus for ultrafiltration of a patient being overhydrated due to congestive heart failure. The apparatus comprises a dilution syringe for removal of a portion of peritoneal fluid from the peritoneal cavity.
Triomed Ab

Heart pump with passive purge system

A heart pump assembly includes an elongate catheter with a proximal portion and a distal portion, a rotor at the distal portion of the elongate catheter, a driveshaft, and a bearing. The rotor can include an impeller blade shaped to induce fluid flow in a first axial direction.
Abiomed, Inc.

Beta-casein a2 and antioxidant capacity

Improving the antioxidant capacity in an animal by increasing the level of glutathione in the blood or tissue of the animal comprising providing a composition containing beta-casein to the animal for consumption, where the beta-casein comprises at least 75% by weight of one or more beta-caseins not capable of producing beta-casomorphin-7 on enzymatic digestion. Uses include as an oxidant, for treating or preventing the symptoms of cancer, inflammation, kwashiorkor (protein deficiency), seizure, autism, down's syndrome, chronic fatigue syndrome, alzheimer's disease, parkinson's disease, sickle cell anaemia, liver disease, cystic fibrosis, hiv, aids, infection, heart attack, stroke, and diabetes, avoiding or reducing the effects of aging, promoting the recovery of tissue following physical exercise, and promoting fertility..
The A2 Milk Company Limited

Novel prodrug salts

Provided are novel prodrug salts of selective aquaporin inhibitors, their use as pharmaceuticals, and pharmaceutical compositions comprising them, and novel processes for their synthesis and novel intermediates for use in their synthesis. Also provided is use of a compound for the prophylaxis, treatment, and control of aquaporin-mediated conditions.
Aeromics, Inc.

Use of a statin compound as local drug for treating obesity, diabetes, hypertension and hyperlipemia

The invention discloses a use of a statin compound in the preparation of local drugs for improving lipid metabolism and treating obesity, hypertension, hyperlipidemia, fatty liver and hyperglycemia; and statin compound local compositions for improving lipid metabolism and treating obesity, hypertension, fatty liver, hyperlipidemia, atherosclerosis, coronary heart disease, apoplexy and other cardiovascular and cerebrovascular diseases, and drug formulation and preparation method thereof.. .
Peking University Third Hospital

Small molecule analogs of the nemo binding peptide

The invention is directed to a method of inhibiting, within a living cell, the interaction between nf-κb essential modulator (“nemo”) with iκb kinase-β (ikk-β) at the nemo binding domain (nbd), comprising exposing the cell to an effective amount or concentration of a compound of the invention, a nemo-binding domain analog (nbda). The invention is further directed to a method of treating a condition in a patient, wherein inhibiting the interaction between nf-κb essential modulator (“nemo”) with iκb kinase-β (ikk-β) at the nemo binding domain (nbd) is medically indicated, comprising administering to the patient an effective dose of a compound of the invention.
The Scripps Research Institute

Detection of myocardial contractions indicative of perfusion

A system for assisting with a cardiopulmonary resuscitation (cpr) treatment being administered to a patient. In one aspect, the system includes electrodes to provide an ecg signal of the patient, one or more sensors configured to measure an intrinsic myocardial wall movement of the patient, and one or more processors.
Zoll Medical Corporation

Covered heart valve sizer

A heart valve sizer and sizer cover are provided for determining the size of a heart valve annulus. The valve sizer can include a handle, a shaft extending distally from the handle, a sizing element coupled to the distal end of the shaft, the sizing element being movable between a first retracted position and a second expanded position, and a sizer cover.
Edwards Lifesciences Corporation

Sealing structures for paravalvular leak protection

A prosthetic heart valve for replacing a native valve includes a collapsible and expandable stent having a proximal end and a distal end, and a valve assembly disposed within the stent, the valve assembly including a plurality of leaflets and a cuff annularly disposed about the stent. The cuff includes a surplus portion capable of forming a sealing structure having a diameter greater than a diameter of the proximal end of the stent when deployed..
St. Jude Medical, Cardiology Division, Inc.

Heart valve support making and using the same

The disclosure relates to a device for supporting functions of a heart valve and methods for making and using the same. The device includes a flow optimizer configured to be located in the valve and having a cross sectional area that reduces a regurgitation orifice of the valve during systole.
Triflo Cardiovascular Inc.

Ablation of myocardial tissues with nanosecond pulsed electric fields

An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied.
Old Dominion University Research Foundation

Non-occlusive circumferential vascular ablation device

A device for internal circumferential ablation of a tubular vascular structure includes an expandable structure having a central opening extending therethrough to allow a relatively unobstructed flow of body fluid through the tubular vascular structure. The expandable structure is expandable from a collapsed configuration to an expanded configuration, with the expandable structure being configured to be secured in a desired location on the tubular vascular structure.
Persistent Afib Solutions, Inc.

Yoke for sensing carotid stenosis

A yoke for use with infrasonic sensing elements, where the yoke is y shaped, flexible, and assists in positioning, on a human subject, the sensing elements appropriately on the carotid arteries and on the heart.. .
Cvr Global Inc.

Compact wearable phonocardiogram and electrocardiogram continuous monitoring system

Apparatus and method are provided to collect and analyze phonocardiogram (pcg) an electrocardiogram (ecg) waveforms. In one novel aspect, the pcg and ecg waveforms are collected from wearable devices.
Bayland Scientific Llc

Device and measuring pressure in a patient's heart

A device for measuring pressure in a patient's heart is provided that comprises a sensor device, which detects the difference in pressure between a point inside the heart and the space lying outside the heart inside the thorax. An element of the sensor device, such as a sensor, may be arranged on a device connected to the heart, such as a heart pump or a cardiac pacemaker..
Berlin Heart Gmbh

System and monitoring and determining patient parameters from sensed venous waveform

Devices, systems, and methods for monitoring patient hemodynamic status, systemic vascular resistance, reversal of cardiac and respiratory rates, and patient respiratory volume or effort are disclosed. A peripheral venous pressure is measured and used to detect levels, changes, or problems relating to patient blood volume.
Baxter Healthcare Sa

System and heart rate monitoring of an object

According to an example aspect of the present invention, there is provided a system for heart rate monitoring of an object, the system comprising means for measuring heart beats of the object with a first unit at a first sampling rate, determining a heart rate, determining a time difference between consecutive heart beats, determining a time of each heart beat, or determining at least a part of a wave form of a heart beat signal, wherein the first unit includes further means for changing the sampling rate as a response to the determined information.. .
Suunto Oy

Self-recoverable multitenant distributed clustered systems

A mechanism is provided for automatically recovering one or more distributed cluster nodes on a host system. Responsive to the host system recovering, restoring, or restarting, a set of distributed clustered systems affected due to the reboot of the host system and details associated with each of the set of distributed clustered systems are identified.
International Business Machines Corporation

Self-recoverable multitenant distributed clustered systems

A mechanism is provided tor automatically recovering one or more distributed cluster nodes on a host system. Responsive to the host system recovering, restoring, or restarting, a set of distributed clustered systems affected due to the reboot of the host system and details associated with each of the set of distributed clustered systems are identified.
International Business Machines Corporation

Method and system for signal decomposition, analysis and reconstruction

A system and method for representing quasi-periodic waveforms, for example, representing a plurality of limited decompositions of the quasi-periodic waveform. Each decomposition includes a first and second amplitude value and at least one time value.
Vios Medical Singapore Pte. Ltd.

Biomarkers for the detection of acute rejection in heart transplantation

The present disclosure relates to methods of diagnosing acute rejection of a cardiac allograft in a subject using genomic expression profiling, proteomic expression profiling, or both on panels of nucleic acid markers and proteomic markers.. .
The University Of British Columbia

Black heart malleable cast iron and manufacturing method thereof

A black heart malleable cast iron including carbon of not lower than 2.0% and not higher than 3.4%; silicon of not lower than 0% and not higher than 1.4%; aluminum of not lower than 2.0% and not higher than 6.0%, which are all expressed by percent by mass; and balance iron and inevitable impurities, wherein a value of a carbon equivalent ce expressed by equation (1) is not lower than 3.0% and not higher than 4.2%, where c denotes a content of the carbon expressed by percent by mass, si denotes a content of the silicon expressed by percent by mass and al denotes a content of the aluminum expressed by percent by mass: ce=c+si/3+al/8 (1).. .
Hitachi Metals, Ltd.

Recombinant adeno-associated vectors for targeted treatment

Novel adeno-associated virus (aav) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues.
City Of Hope

Micro-rna family that modulates fibrosis and uses thereof

The present invention relates to the identification of a microrna family, designated mir-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the mir-29 family are down-regulated in the heart tissue in response to stress, and are up-regulated in heart tissue of mice that are resistant to both stress and fibrosis.
The Board Of Regents, The University Of Texas System

Intracardiac capsule and an implantation accessory for use with the femoral artery

An assembly including an autonomous capsule having an anchoring member adapted to penetrate tissue of the heart and an accessory for implantation of the capsule. The accessory includes a steerable catheter with an inner lumen, having at its distal end a tubular protection tip defining a volume for housing the capsule.
Sorin Crm S.a.s.

Methods, devices, and systems for percutaneously anchoring annuloplasty rings

Apparatus, systems, and methods are provided for percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves. An annuloplasty ring includes an outer tube, an inner body member, and an anchor deployment system.
Valcare, Inc.

Percutaneous annuloplasty system with anterior-posterior adjustment

Apparatus, systems, and methods are provided for repairing heart valves through percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves. An annuloplasty ring includes an outer hollow body member including a plurality of regions.
Valcare, Inc.

Commissure attachment features for improved delivery flexibility and tracking

A prosthetic heart valve includes a collapsible and expandable stent having a proximal end and a distal end. A plurality of commissure attachment features (“cafs”) is disposed on the stent, with each caf including a body and a plurality of eyelets.
St. Jude Medical, Cardiology Division, Inc.

Transcatheter valve prosthesis

A heart valve system, the system including a radially self-expandable tubular body, a valve, and a tubular fabric. The tubular body having an inflow end and an outflow end.
Highlife Sas

Prosthetic heart valve

A prosthetic heart valve (1) for implantation at the mitral annulus of a heart, the prosthetic heart valve comprising: a support framework (10) reversibly transformable between a collapsed configuration and an expanded configuration; and one or more leaflets connected to the framework; wherein, in the expanded configuration: the support framework defines a fluid pathway through the prosthetic heart valve, the fluid pathway having a portion with a d-shaped cross section for engaging the mitral annulus; and the one or more leaflets allow fluid to pass through the fluid pathway in a first direction but prevent fluid from flowing in the opposite direction.. .
Ucl Business Plc

Method and system for image processing to determine blood flow

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data.
Heartflow Inc.

Evaluating prosthetic heart valve placement

A method for evaluating the placement of a prosthetic heart valve in a structure of interest. The method comprises acquiring one or more depictions of an anatomical region of interest that includes the structure of interest, wherein each depiction shows the structure of interest and/or the blood pool volume of the left ventricular outflow tract (lvot) of the patient's heart.
Henry Ford Health System

Implantable medical device and system to heat tissue

A medical implant device (18) for atrial appendage (20) is presented, suitable to transmit energy to its surrounding. The medical implant device (18) comprising an expandable structure (31,34) and a cover (32) disposed on the expandable structure is adapted to extend across the ostium (21) of the atrial appendage (20) for restricting migration of thrombi from the appendage to the blood stream in the heart (13).
Koninklijke Philips N.v.

Ultrasonic diagnosis of cardiac performance using heart model chamber segmentation with user control

An ultrasonic diagnostic imaging system has a user control by which a user positions the user's selection of a heart chamber border in relation to two myocardial boundaries identified by a deformable heart model. The user's border is positioned by a single degree of freedom control which positions the border as a function of a single user- determined value.
Koninklijke Philips N.v.

Heart-rate adaptive pulse oximetry

Embodiments are directed to methods and systems for adaptive heart rate monitoring. In one scenario, a method for adaptive heart rate monitoring includes receiving, from a pulse-oximeter, a sensor signal, where the sensor signal is photoplethysmogram waveform.
Owlet Baby Care, Inc.

Real time electroanatomical coloring of the heart

Cardiac catheterization is conducted with a probe having a plurality of sensors. The heart is displayed as a first graphic image.
Biosense Webster (israel) Ltd.

Ablation condition determination methods and systems

A method and apparatus are disclosed for determining if a previously carried out heart ablation has been effective in isolating tissue. The method involves inserting an esophageal device, e.g.
Plymouth Hospitals Nhs Trust

Method and evaluating cardiac function

A method for assessing the electrical function of a heart that includes: (1) for each of a plurality of leads of an ecg, determining a value derived from the output of that lead and which corresponds to an action potential duration; (2) for each of the plurality of leads of the ecg, determining a value derived from the output of that lead and which corresponds to a diastolic interval; (3) for each of the plurality of leads of the ecg, determining a relationship between the determined values for action potential duration and for diastolic interval; and (4) assessing the differences between the determined relationships for each of the plurality of leads. The invention further relates to apparatus and a computer program that may be used in the method..
University Of Leicester

Method and detecting atrial fibrillation

A method of detecting atrial fibrillation includes detecting a pulse signal to obtain a time pulse waveform and converting it to an energy spectrum waveform via fast fourier transform. The energy spectrum waveform includes a first frequency region, a second frequency region, and a third frequency region.

Physical ability evaluation system, electronic apparatus, physical ability evaluation server, physical ability evaluation method, physical ability evaluation program, and recording medium

A physical ability evaluation system includes an output unit that outputs a plurality of indexes related to heart beat information of a user as information related to balance of a physical ability of the user.. .
Seiko Epson Corporation

Health and fitness monitor for determining a minimum heart rate

Methods and apparatus, including computer program products, are provided for analyzing heart rate data for a fitness or health device. In some example embodiments, there may be provided an apparatus that includes at least one processor and at least one memory including program code which when executed configures the apparatus to at least: receive, from at least one heart rate sensor, a heart rate data set collected from a subject over at least one session; filter the heart rate data set to remove at least one heart rate value failing to satisfy a predetermined duration threshold; determine a minimum heart rate value from the filtered heart rate data; and provide the determined minimum heart rate.
Nokia Technologies Oy

A device and non-invasive left ventricular end diastolic pressure (lvedp) measurement

The present application relates to systems and methods for non-invasively determining at least one of left ventricular end diastolic pressure (lvedp) or pulmonary capillary wedge pressure (pcwp) in a subject's heart, comprising: receiving, by a computer, a plurality of signals from a plurality of non-invasive sensors that measure a plurality of physiological effects that are correlated with functioning of said subject's heart, said plurality of physiological effects including at least one signal correlated with left ventricular blood pressure and at least one signal correlated with timing of heartbeat cycles of said subject's heart; training a machine learning model on said computer using said plurality of signals for periods of time in which said plurality of signals were being generated during a heart failure event of said subject's heart; determining said lvedp or pcwp using said machine learning model at a time subsequent to said training and subsequent to said heart failure event.. .
Boston Scientific Scimed Inc.

Cardiovascular parameter estimation in the presence of motion

Disclosed embodiments pertain to cardiovascular parameter (e.g. Heart rate) measurements when motion is present.
Qualcomm Incorporated

System and a wearable medical simulator

A system and method for providing a medical simulation system that adds high-fidelity features to manikin simulators and standardized patients. The medical simulation system includes wearable components that contain modules for simulating pulses, heart and lung sounds, and breathing motion.
The General Hospital Corporation

Updating an electroanatomical map

Described embodiments include a system for updating a mesh, which includes a plurality of vertices, representing a surface of a heart. The system includes an electrical interface and a processor.
Biosense Webster (israel) Ltd.

Submersible inspection device and redundant wireless communicaiton with a base station

A submersible inspection device used for inspection of, for example, liquid cooled electrical transformers can include a number of separate cameras for imaging the internal structure of the transformer. The submersible can be configured to communicate to a base station using a number of wireless transmitters and receivers.
Abb Schweiz Ag

Optical micromesh for computerized devices

Multiple camera systems which use laser illumination for ranging benefit from a heartbeat to synchronize the timing of the individual lasers to eliminate collisions of multiple simultaneous laser emissions. An optical micromesh system provides for the dynamic entry and egress of mobile and stationary nodes.
Sony Interactive Entertainment Inc.

Transcriptomic biomarker of myocarditis

Molecular signatures that function as very sensitive diagnostic biomarker for myocarditis, heart disease and disorders thereof, are identified.. .
University Of Miami

Methods for treatment of cardiovascular disease

This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to diagnose and/or treat cardiovascular conditions including cardiac hypertrophy, myocardial infarction, stroke, arteriosclerosis, and heart failure..
Brigham And Women's Hospital, Inc.

Methods for treatment with bucindolol based on genetic targeting

The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer or prescribe bucindolol to a patient based on whether the patient is homozygous for the arg 389 polymorphism in the β1-adrenergic receptor (ar)..
The Regents Of The University Of Colorado, A Body Corporate

Kit for diagnosis of coronary heart disease using multi-metabolites and clinical parameters, and diagnosis of coronary heart disease using the same

The present disclosure relates to a method and a diagnostic kit for diagnosing stable angina and acute myocardial infarction early through simple blood testing and checking of clinical parameters. Unlike conventional diagnostic methods, stable angina can be diagnosed as distinguished from acute myocardial infarction according to the present disclosure by using one diagnostic platform based on the change in the in-vivo levels of biological metabolites having different metabolic pathways and clinical parameters as well as medications affecting the onset and progress of the disease through multivariable analysis..
Korea Institute Of Science And Technology

Methods for treating cardiovascular diseases

Provided herein are methods that relate to a novel therapeutic strategy for treatment of heart and/or cardiovascular diseases. The method includes administration of loxl2 inhibitors for treating, preventing, or ameliorating at least one symptom associated with heart and/or cardiovascular diseases..
Gilead Sciences, Inc.

Control device for an electric bicycle

A control device for an electric bicycle includes a motor, a battery, a micro controller, an acceleration detector and a transmitter electrically connected to each other. A physical-condition monitor detects the rider's heart rate signal.

Leadless cardiac stimulation device employing distributed logic

Systems and methods involve an intrathoracic cardiac stimulation device operable to provide autonomous cardiac sensing and energy delivery. The cardiac stimulation device includes a housing configured for intrathoracic placement relative to a patient's heart.
Cardiac Pacemakers, Inc.

Coordinating musculoskeletal and cardiovascular hemodynamics

The present invention is generally directed to methods, systems, and computer program products for coordinating musculoskeletal and cardiovascular hemodynamics. In some embodiments, a heart pacing signal causes heart contractions to occur with an essentially constant time relationship with respect to rhythmic musculoskeletal activity.
Pulson, Inc.

Congestive heart failure therapy device

Provided is a congestive heart failure therapy device that applies a positive pressure within an optimal range depending on the condition of a congestive heart failure (chf) patient. Provided is a positive pressure therapy device for congestive heart failure patients, comprising: a pressure raising unit configured to raise the pressure of air, or a gas mixture of air and other gases, to a positive pressure; an introducing unit configured to introduce the air or the gas mixture set to a positive pressure into the airways of the patient; and a blood oxygen level measurement unit configured to measure the blood oxygen level of the patient, a blood flow rate measuring unit configured to measure a blood flow rate of the patient, or a cardiac output measuring unit configured to measure a cardiac output of the patient.
Teijin Pharma Limited

Self-contained heart pump

A heart pump includes a rotative impeller partly inserted into the systemic ventricle, this rotative impeller being equipped with a membrane sutured to the outer wall of the heart in such a way as to secure the rotative impeller to the wall of the heart, a housing arranged inside the systemic ventricle in such a way as to draw up then discharge blood, a motor connected to the housing and arranged partly outside the systemic ventricle in such a way as to facilitate maintenance; an integrated management unit in the epigastric region including a power supply and a rotative impeller control unit; and a wired link between the management unit and the rotative impeller.. .
Fineheart

Dual-pump continuous-flow total artificial heart

A total artificial heart for a mammalian cardiovascular system is provided. The total artificial heart has a pump casing including an outer housing and an integral hollow support shaft extending therethrough.
Drexel University

Rapid exchange transcatheter valve delivery system

A delivery device for implanting a prosthetic heart valve. The device includes an inner shaft assembly, an outer sheath and a connector assembly.
Medtronic Vascular, Inc.

Transcatheter delivery system with two modes of actuation

A delivery device for a collapsible prosthetic heart valve, the delivery device comprising an inner shaft, a distal sheath disposed about a portion of the inner shaft and forming a compartment with the inner shaft, the compartment adapted to receive the valve, the inner shaft and the distal sheath being slidable relative to one another, and a handle including a frame, a deployment actuator, a lever, and a hub, each of the deployment actuator, the lever, and the hub being independently capable of opening and closing the compartment, a resheathing lock configured to alert a user of a position of the distal sheath relative to the inner shaft and to impede movement of the distal sheath relative to the frame, and an indicator disposed on the frame and capable of showing an extent of deployment of the valve.. .
St. Jude Medical, Cardiology Division, Inc.

Transcatheter delivery system with transverse wheel actuation

A delivery device for a collapsible prosthetic heart valve, the delivery device including an inner shaft, a distal sheath disposed about a portion of the inner shaft and forming a compartment with the inner shaft, the compartment adapted to receive the valve, the inner shaft and the distal sheath being movable relative to one another, and a handle including a frame having a longitudinal axis, a proximal end and a distal end, the handle including a deployment actuator and a hub, the deployment actuator and the hub being independently capable of opening and closing the compartment, a resheathing lock configured to alert a user of a position of the distal sheath and to impede movement of the distal sheath, and an indicator disposed on the frame and capable of showing an extent of deployment of the valve.. .
St. Jude Medical, Cardiology Division, Inc.

Prosthetic heart valve delivery system with controlled expansion

A system for repairing a defective heart valve. The system includes a delivery device, a balloon and a prosthetic heart valve.
Medtronic Vascular, Inc.

Devices, systems and methods to improve placement and prevent heart block with percutaneous aortic valve replacement

Devices, systems and methods to position a prosthetic heart valve such that the prosthetic valve does not compress conduction tissue and thereby produce heart block. Guide devices promote positioning the prosthetic valve within a native aortic valve to avoid the conduction tissue and, optionally, to center the prosthetic valve within the native heart valve.

Mechanically expanding heart valve and delivery apparatus therefor

An assembly can comprise a radially expandable and compressible annular frame, at least one linear actuator assembly coupled to the frame and at least one locking mechanism coupled to the frame. The linear actuator can be configured to apply a distally directed force and/or a proximally directed force to the frame to radially expand or compress the frame.
Edwards Lifesciences Corporation

Heart valve remodeling device

A heart valve remodeling device may include a delivery device including an inner shaft slidably disposed over a guidewire and an outer shaft slidably disposed over the inner shaft, and a braided stent fixedly attached to the inner shaft and the outer shaft. The braided stent may be translatable between an elongated configuration and a deployed configuration by movement of the inner shaft relative to the outer shaft.
Boston Scientific Scimed, Inc.

Mitral valve prosthesis for transcatheter valve implantation

A transcatheter valve prosthesis is disclosed that has a compressed, delivery configuration and an expanded configuration for deployment within a native heart valve. The valve prosthesis includes a self-expanding frame and a prosthetic valve component.
Medtronic Vascular Galway

Heart rate assistance for phase determination in echocardiography

A heart rate monitor provides a pulse or heartbeat, but without the on-going or continuous phase signal of ecg and/or with a delay relative to the actual heartbeat. For phase determination in echocardiography, the heartbeat from the heart rate monitor is used to assist in identification of phase from acquired ultrasound data.

Stand-alone continuous cardiac doppler pulse monitoring patch with integral visual and auditory alerts, and patch-display system and method

A stand-alone continuous cardiac doppler pulse monitoring patch provides visual and auditory signals that a pulse is detected or not detected in a human subject. The invention is a small patch with a peel-away adhesive surface that is applied to the skin of the subject, preferably near a large artery.

Determining c-arm angulation for valve positioning

The present invention relates to determining optimal c-arm angulation for heart valve positioning. In order to further improve the workflow in relation with the correct positioning of a valve prosthesis, it is described to provide (12) a 2d image of an aortic root of a heart of a patient, wherein the 2d image comprises three cusps of the heart in a visible and distinct manner.
Koninklijke Philips N.v.

Wrist device and arrangement for measuring and testing performance

A wrist device includes a performance measuring unit, a skin temperature measuring unit, and a processing unit. The performance measuring unit measures performance data of a user, which includes heart rate of the user measured with a pulse detector and acceleration related to movement of the user measured with an acceleration sensor.
Polar Electro Oy

Method and vital signs measurement

A method of monitoring changes in oxygen saturation of a subject by analysing a three colour channel video image of the exposed skin of the subject. Within each colour channel a normalised signal obtained by dividing the intensity signal by its mean value, and the normalised signals are averaged across plural regions of interest within the exposed skin area image of the subject.
Oxford University Innovation Limited

Diagnosis and monitoring of cardio-respiratory disorders

Methods and systems estimate cardio-respiratory parameter(s), such as from in-phase and quadrature channels. The channels may represent patient chest movement and may be generated with a sensor, such as a contactless sensor that may sense movement with radio-frequency signals.
University Of Technology Sydney

Phenotyping sensor patterns to identify and treat heart failure

This document discusses, among other things, systems and methods to receive physiologic information from a patient and to generate a heart failure status using the received physiologic information. Based on the received physiologic information, the generated heart failure status can be classified into at least one of a set of predetermined phenotype clusters..
Cardiac Pacemakers, Inc.

Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status

The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
Transmedics, Inc.

System and workstation for, and , deterring theft of a product associated with a target to be electro-optically read

Successive products associated with targets to be electro-optically read are swiped, in their respective turns, past a window in a point-of-transaction workstation. A motion detector detects movement of each product.
Symbol Technologies, Llc

Dual-display smart watch with proximal and distal (analog and electronic) displays

This invention is a dual-display smart watch with a proximal dorsal display and a distal dorsal display. In an example, the proximal and distal displays can both be electronic displays.
Medibotics Llc

Novel micro-dystrophins and related methods of use

Nucleotide sequences including a micro-dystrophin gene are provided. The micro-dystrophin genes may be operatively linked to a regulatory cassette.
University Of Washington

Cholic acid derivative, and preparation method and medical use thereof

The present invention relates to a cholic acid derivative, and a preparation method and a medical use thereof. In particular, the present invention relates to a cholic acid derivative of formula (i), a stereoisomer, or a pharmaceutically acceptable salt thereof.
Shanghai Hansoh Biomedical Co., Ltd.

Substituted 2-(chroman-6-yloxyl)-thiazoles and their use as pharmaceuticals

In which ar, r2, r3 and r4 are as defined in the claims. The compounds of the formula i are inhibitors of the sodium-calcium exchanger (ncx), especially of the sodium-calcium exchanger of subtype 1 (ncx1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke.

Methods and devices for producing trabecular fibers

A device for producing a trabecular fiber within a ventricle of a heart. The device includes a substrate and a first tissue anchor connected to the substrate.
Boston Scientific Scimed Inc.

Methods and systems for treating acute heart failure by neuromodulation

Methods of treating acute heart failure in a patient in need thereof. Methods include inserting a therapy delivery device into a pulmonary artery of the patient and applying a therapy signal to autonomic cardiopulmonary fibers surrounding the pulmonary artery.
The Cleveland Clinic Foundation

Devices, methods and systems for establishing supplemental blood flow in the circulatory system

Devices, systems and methods for establishing a blood flow conduit between a chamber in a heart of a patient and a remote location. A blood inflow cannula having an outer surface and proximal and distal end portions.
Circulite, Inc.

Pre-stressing and capping bioprosthetic tissue

A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification is disclosed. The method includes preconditioning, pre-stressing, or pre-damaging fixed bioprosthetic tissue in a manner that mimics the damage associated with post-implant use, while, and/or subsequently applying a calcification mitigant such as a capping agent or a linking agent to the damaged tissue.
Edwards Lifesciences Corporation

Risk stratification

The present invention relates to a method of in vivo imaging with meta-[123i]iodobenzylguanidine ([123i]mibg) and more particularly wherein said method is used to stratify a defined subset of subjects with heart failure into particular treatment regimens.. .
Ge Healthcare Limited

Risk stratification

The present invention relates to a method of in vivo imaging with meta-[123i]iodobenzylguanidine ([123i]mibg) and more particularly wherein said method is used to stratify a defined subset of subjects with heart failure into particular treatment regimens.. .
Ge Healthcare Limited

Method for isolation of alkaloids and amino acids, and compositions containing isolated alkaloids and amino acids

Described herein are methods to purify alkaloids and amino acids. Also described are compositions and methods to treat or prevent a disease using the purified amino acids and alkaloids.

Two step mitral valve

A dual member stent-valve for transcatheter delivery to a native heart valve needing replacement. A first component is attached to the native annulus upstream of the native leaflets maintaining native leaflet function, and is held to the native annulus by barbs that are activated by a torus balloon after the first component is fully expanded.

Methods of conformal expansion of prosthetic heart valves

A system for expanding a device in a conduit or orifice of a human body includes a balloon member that is movable from a first configuration to a second configuration. External surfaces of the balloon member can collectively have a non-cylindrical cross-section relative to a main axis of the balloon member, such that the external surfaces of the balloon member generally conform to the anatomical shape of the conduit or orifice when the balloon member is in the second configuration..
Edwards Lifesciences Corporation

Replacement heart valve

A replacement heart valve assembly has a stent frame and a replacement valve. The replacement valve has a plurality of leaflets and a valve frame.
Boston Scientific Scimed, Inc.

Paravalvular leak sealing mechanism

A collapsible and expandable stent body includes a generally tubular annulus section, one or more prosthetic valve elements mounted to the stent body, and a cuff attached to the stent body. The prosthetic valve is operative to allow flow in an antegrade direction but to substantially block flow in a retrograde direction.
St. Jude Medical, Cardiology Division, Inc.

System and replacing an inflamed or infected heart valve

The invention relates to a system for replacing a heart valve that is diseased owing to inflammation and/or an infection. The system has: a stent system with at least one expandable stent; and a replacement heart valve which is secured to the at least one stent and has at least two heart valve leaflets.

Prosthetic valves and related inventions

This invention relates to the design and function of a compressible valve replacement prosthesis, collared or uncollared, which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction.
Tendyne Holdings, Inc.

Percutaneous leaflet augmentation

In a representative embodiment, an implantable prosthetic heart valve device comprises an elongated body having first and second end portions, the body being configured to be implanted around a native leaflet of a heart valve such that the first end portion is on an atrial side of the leaflet and the second end portion is on a ventricular side of the leaflet and such that the body can coapt with and move away from an opposing native leaflet during operation of the heart valve. The device can further comprises a fastener configured to be mounted on a suture that extends from one of the first or second end portions, through the native leaflet and through the other of the first or second end portions such that the body is secured to the native leaflet..
Edwards Lifesciences Corporation

Tissue cutting device and system

The present disclosure relates to a tissue cutting system for cutting tissue of a heart, such as tissue of a septum of a heart, comprising: an outer tubular member having a proximal portion and a distal portion, said distal portion comprising a tissue resection window; a resection element axially slidably arranged inside the outer tubular member configured to resect tissue extending through the tissue resection window; at least one pressure sensor; wherein the outer tubular member and resection element are arranged to establish: a first fluid flow channel suitable for transporting resected tissue away from an area adjacent to the resection element; at least one second fluid flow channel configured to assist the first fluid flow channel in transporting resected tissue. The present disclosure further relates to a method for resecting tissue using the disclosed tissue cutting system..
Septulus Ab

Cinch and post for tricuspid valve repair

A system for repairing a tricuspid valve in a patient's heart comprising a post having a distal end and a proximal end, a capture element attached to the distal end of the post, the capture element including: a plurality of arms each having a first end and a second end, each arm attached at the first end to the post and extending both radially outwardly from the post and proximally, each arm defining an opening at the second end; a wire passing sequentially through the opening on each arm, whereby tensioning the wire draws the second end of each arm towards the post.. .
Abbott Cardiovascular Systems Inc.

Device for predicting ventricular arrhythmia and method therefor

A method for predicting ventricular arrhythmia includes a step of receiving at least one of an electrocardiogram signal and a respiration signal of a ventricular arrhythmia patient; a step of acquiring at least one of parameter values for heart rate variability and respiratory variability of the ventricular arrhythmia patient by analyzing at least one of the electrocardiogram signal and the respiration signal of the ventricular arrhythmia patient; a step of generating a ventricular arrhythmia estimation algorithm for predicting whether or not ventricular arrhythmia occurs by using the acquired parameter values; a step of predicting whether or not ventricular arrhythmia of a user occurs by applying at least one of the parameter values for the heart rate variability and the respiratory variability of the user to the ventricular arrhythmia estimation algorithm; and a step of outputting prediction results as to whether or not the ventricular arrhythmia occurs.. .
University Of Ulsan Foundation For Industry Cooperation

Sleep stage determination apparatus and sleep stage determination method

A sleep stage determination apparatus is provided with: a first normalization unit that performs a first normalization processing on the intensity of a user's heartbeat signal calculated using a gain value of gain control that is performed on the heartbeat signal so that the peak value is controlled to be constant; a second normalization unit that performs a second normalization processing on the intensity of the heartbeat signal; a third normalization unit that performs a third normalization processing on a first normalized heartbeat intensity; and a sleep stage determination unit that determines the stage of sleep on the basis of the second normalized heartbeat intensity obtained by the second normalization unit and variances indicating data variations in a predetermined period calculated for the normalized heartbeat intensity data obtained by the first normalization unit and the third normalization unit.. .
Sleep System Laboratory Inc.

Sensing at least one biological parameter, e.g., heart rate or heart rate variability of a subject

The present disclosure concerns a device for sensing at least one biological parameter (e.g., heart rate, heart rate variability) of a subject, the device comprising a contact surface configured for being brought into a contact with a skin surface of the subject. The device has at least one light source for illuminating the skin surface through the contact surface along an illumination source optical axis with illumination including at least one sensing wavelength, and at least one detector for detecting a response of said illumination at least at said wavelength, from the skin surface through the contact surface along a detector optical axis, and providing signals configured for determining said biological parameter based thereon, said illumination optical axis forming with said contact surface an acute included angle..
Cardiacsense Ltd.

Cutaneous blood flow monitoring device

A method and a device for diagnostic of skin cancer and other mammalian skin tissue pathologies are described. The method relies on determination of pathological changes in tissue vascularization and capillary blood flow.
Veriskin, Inc.

Method and computer system for processing a heart sensor output

The disclosure relates to a method and system for processing a heart sensor output, wherein a blood flow and a simulated aortic blood pressure are derived from a sensed blood pressure using an arterial flow model and values for arterial flow parameters. The simulated aortic blood pressure is matched to a part of the sensed blood pressure in the cardiac cycle by manipulating at least one of the values for the arterial flow parameters of the arterial flow model..

Heart failure management

Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors.
Cardiac Pacemakers, Inc.

Gemstone having hearts and arrows pattern and cutting the same

This disclosure relates to a round gemstone having a hearts and arrows pattern of ten hearts and arrows. The gemstone comprises a girdle, a crown and a pavilion.

Floribunda rose plant named 'wekwibysicpep'

A new variety of floribunda rose suitable for garden decoration, having flowers of lavender with a magenta heart coloration.. .
Walters Gardens, Inc.

Broadcast synchronization

A first media server delivers content for broadcast via a first media channel, and a second media server delivers media content for broadcast via a second media channel. The first media server operates in a synchronized mode, under control of the second media server during some periods of time, and during other periods of time operates in an independent mode.
Iheartmedia Management Services, Inc.

Diagnostic of heart failure

The invention relates to a method for classifying a patient at risk for heart failure, wherein said method comprises the steps of (i) measuring the concentration of igfbp2 in a sample obtained from said patient and (ii) comparing the concentration of igfbp2 measured in step (i) to a control value derived from the concentration of igfbp2 in samples from patients who are at particular stages of heart failure and/or to a control value derived from the concentration of igfbp2 in blood samples from healthy patients.. .
Centre Hospitalier Universitaire De Toulouse

Ultrasensitive high q-factor at-cut-quartz crystal microbalance femtogram mass sensor

A device for cost-effective and sensitive diagnostics is provided to detect environmental contaminants, diseases, and acute medical conditions related to heart failure. The device identifies pathogens or troponins before infection or damage to heart muscles using an ultrasensitive high q-factor at-cut quartz crystal microbalance (qcm) that can measure from a single pg to a single fg.
University Of Alberta

Protective vest apparatus and system

A protective vest and associated system are described. The vest may include at least one cooling subsystem configured to cool the torso of the wearer.

Substituted piperidinyl tetrahydroquinolines

The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, raynaud's phenomenon, crest syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.. .
Bayer Pharma Aktiengesellschaft

Substituted piperidinyl tetrahydroquinolines

The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, raynaud's phenomenon, crest syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.. .
Bayer Pharma Aktiengesellschaft

Preparation of (r,r)-fenoterol and (r,r)- or (r,s)-fenoterol analogues and their use in treating congestive heart failure

This disclosure concerns the discovery of (r,r)- and (r,s)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv

Training program customization using sensor-equipped athletic garments

An exercise feedback system monitors the performance of athletes wearing a garment with sensors while exercising. The sensors generate physiological data such as muscle activation data, heart rate data, or data describing the athlete's movement.
Mad Apparel, Inc.

Exercise biofeedback using sensor-equipped athletic garments

An exercise feedback system monitors the performance of athletes wearing a garment with sensors while exercising. The sensors generate physiological data such as muscle activation data, heart rate data, or data describing the athlete's movement.
Mad Apparel, Inc.

Devices and methods for inhibiting stenosis, obstruction, or calcification of a native heart valve, stented heart valve or bioprosthesis

The present invention relates to methods for inhibiting stenosis, obstruction, or calcification of a valve following implantation of a valve prosthesis or a native valve which develops disease via the lrp5/wnt pathway in the presence of elevated lipids due to elevated low density lipoprotein. This invention involves dispensing a combination of medications to target inflammation and attachment of the target cell and the secondary drugs to inhibit proliferation and calcification on an elastical stent, gortex graft or valve leaflet.
Concievalve Llc

Methods and compositions for treatment of heart failure

The present invention relates to methods and compositions for treating heart failure in a subject using histone deacetylase (hdac) inhibitors and/or histone acetyltransferases (hat) activators.. .
The University Of North Carolina At Chapel Hill

Combination of an h2-receptor antagonist, antacid, and alginic acid to treat episodic heartburn

A combination of an antacid, alginate, and a histamine h2-receptor antagonist, and methods of using the same for providing fast and lasting relief of symptoms of episodic heartburn are provided.. .

Method for improving kidney and/or heart function in patients with kidney disease

Disclosed herein is novel use of telbivudine for improving kidney and/or heart function of a subject suffering from a kidney disease, such as acute kidney injury (aki) or chronic kidney disease (ckd).. .

Combination therapy of cardiac myosin activator and sinus node if current inhibitor

Disclosed herein are combination therapies for the treatment of heart failure using a cardiac myosin activator, such as omecamtiv mecarbil, and a sinus node if current inhibitor, such as ivabradine. Also disclosed herein are compositions comprising a cardiac myosin activator and a sinus node if current inhibitor..
Amgen Inc.

Metabolically programmed metal chelators and uses thereof

The present invention provides compounds of formula (i), which are “metabolically programmed” metal chelators, e.g., lipophilic, absorbable (e.g., orally absorbable), and effective metal chelators that are converted in vivo to their hydrophilic, nontoxic metabolites. The present invention also provides compounds of formula (ii), which are also “metabolically programmed” metal chelators.
University Of Florida Research Foundation, Incorporated

Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin

There is disclosed a method for administration of a formulation of resiniferatoxin (rtx) to provide cardiac sympathetic afferent denervation when applied in an amount and concentration sufficient to chemically denervate vanilloid 1 receptor (trpv1)-expressing csar (cardiac sympathetic afferent reflex) afferents. There is further disclosed a method for treating heart failure or hypertension and its related indications selected from the group consisting of increased sympatho-excitation, cardiac hypertrophy, increased left ventricular end diastolic pressure (lvedp), lung edema, and combinations thereof, comprising administering an effective amount of rtx directly to a tissue site selected from the group consisting of epicardium, a t1-t4 dorsal root ganglion and intrathecally to the t1-t4 region of the spinal column..
Board Of Regents Of The University Of Nebraska

Methods and systems for rapid retraction of a transcatheter heart valve delivery system

Methods for the rapid retraction of trans-catheter heart valve delivery systems are provided. A rapid retraction trans-catheter heart valve delivery system comprises a catheter based delivery system.
Neovasc Tiara Inc.

Device and methods for self-centering a guide catheter

This document provides devices and methods for the treatment of heart conditions such as valvular stenosis. For example, this document provides devices and methods by which a guide catheter can align itself with a blood flow stream to thereby help direct a guidewire or other elongate device transmitted from the guide catheter through an orifice of a heart valve..
Mayo Foundation For Medical Education And Research

Tissue heart valve (thv) humidor packaging system

A prosthetic valve packaging system includes a jar, a lid, a lid liner, and a humectant. The jar has a closed end, an open end, a side wall and an interior sized to receive the prosthetic heart valve.
St. Jude Medical, Cardiology Division, Inc.

Method and arrangement for electromagnetic radiation based non-invasive monitoring of a performance of an anatomic object during an operation or medical intervention

An arrangement for electromagnetic radiation based non-invasive monitoring of an anatomic object during an operation includes at least one imaging device for obtaining at least two or more images of at least one surface point on a surface of the anatomic object over at least one fraction of a characteristic movement cycle from the surface of the anatomic object. In addition the arrangement includes an output for a display device or the display device, and a control unit for determining deformation based on movements of the at least one surface point over the at least one fraction of the cycle between the at least two or more images of the surface of the heart in function of time.
Tty-saatio Sr

Method and system for modeling blood flow with boundary conditions for optimized diagnostic performance

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data.
Heartflow, Inc.

Photoplethysmography (ppg) indication discontinuity detection and correction

Methods and devices for heart rate monitoring may include determining whether an adjustment triggering condition has been met. Moreover, the methods and devices may include, in accordance with a determination that the adjustment triggering condition has been met, adjusting the second sensor indication to obtain an adjusted second sensor indication based at least on the difference between the first sensor indication and the second sensor indication.
Microsoft Technology Licensing, Llc

Devices and methods for monitoring physiologic parameters

Devices and methods for monitoring physiologic parameters are described where an airway device, in one embodiment, may comprise a mouthpiece section and an opening section defining one or more airway lumens therethrough with a first sensor in fluid communication with the one or more airway lumens and a second sensor positioned upon a hand-piece for contact against a portion of the user. The first sensor may be configured to detect an airway pressure when a user inhales or exhales through the one or more airway lumens, and the second sensor may be configured to detect a physiological signal from the user.
Respirix, Inc.

System and biometric identification using sleep physiology

The claimed invention comprises software methods for user continuity and physiological state change assessments through generating biometric profiles of individuals and/or groups of individuals by using physiological input together with biomathematical modeling and machine learning techniques. Intra-individual variation in physiological variables including, but not limited to: heart rate, heart rate variability, pulse waveform and its derivatives, blood pressure, breathing rate, cardiopulmonary coupling, actigraphy and circadian rhythms characteristics, are exploited..
Lifeq Global Limited

Cardiac activation time detection

A method for characterizing an electrocardiogram, including receiving a first unipolar signal from a first location of a heart and a second unipolar signal from a second location of the heart. The method further includes generating a bipolar signal from the first and second unipolar signals, and analyzing the bipolar signal to delineate a time period during which the first and second locations generate a bipolar complex.
Biosense Webster (israel) Ltd.

Method for obtaining heart rate and electronic device for the same

An electronic device and a method are provided. The electronic device can include a motion sensor, a heart rate monitor sensor, and a processor functionally coupled with the motion sensor and the heart rate monitor sensor.
Samsung Electronics Co., Ltd.

Passport-controlled firewall

A method, and associated system and computer program product, for modifying rules in a firewall infrastructure are described. A unit of deployment including application code and a signed passport is received at a requestor module on a server.
International Business Machines Corporation

Wearable device charger

Wrist-mounted monitors (e.g., heart rate monitors) can include rechargeable power sources, which can be recharged at a single charging base. Each of the monitors can be placed at a respective charging station of the charging base.
The Prophet Corporation

Marking sparse areas on maps

Values of a physiologic parameter at respective measured points in a heart are obtained. A 3-dimensional model of the heart is constructed, which includes first spatial elements that include the measured points and second spatial elements that do not include the measured points.
Biosense Webster (israel) Ltd.

Lgr5+ somatic stem cells

A method for treating a condition, comprising administering to a subject in need thereof a composition that contains somatic stem cells that are 2 to less than 6 micrometers in size and lgr5+, wherein the condition is selected from the group consisting of neurodegenerative disorder, muscle-degenerative disease, cancer, metabolic disorder, autoimmune disorder, inflammatory disorder, heart disorder, circulatory disorder, a condition associated with aging, and damaged tissue.. .
Stembios Technologies, Inc.

Independently automated loading system for unitized loads into a covered multi-level transporter

An automated mechanical loading system for loading seedling carriers into a transporter bin for transport to the field for planting. The system of the present invention includes a transport bin having a plurality of rails mounted on the inside walls of the bin for accepting a plurality of carriers, power driven projections slidably mounted on sleds which are fixedly mounted to the top frame of a lift for urging one or more carriers into a preselected set of opposing rails in the bin.
Greenheart Farms, Inc.

Method and intrachamber resynchronization

Methods, apparatus, and systems are provided to control contraction of the heart. At least one sensing element receives signals indicating electrical activity of sinus rhythm of the heart.
Mirowski Family Ventures, Llc

Heart assist system and methods

A system for drawing blood from a heart of a patient, includes a blood pump, an outflow cannula and a flexible cannula assembly. The cannula assembly further includes a flexible cannula body including a proximal end, a distal end, an inner wall defining a lumen, and an outer wall.
Circulite, Inc.

Cmlck gene transfer

The invention relates to compositions and methods for cmlck gene transfer. In some aspects, the invention provides compositions and methods for treating advanced heart failure in a subject by cmlck gene transfer, in particular, by administering to a subject an effective amount of a polynucleotide vector that encodes a cmlck protein, expressing the cmlck protein from the polynucleotide vector in the heart cells of the subject, and improving ventricular function of the heart.
Zensun (shanghai) Science & Technology, Co., Ltd.

Therapeutic ozone agent and treatment

The use of a medical therapeutic ozone agent in vivo to treat a variety of disorders including, but not limited to hypoxic conditions, autoimmune disease, fibrotic disease, inflammatory disease, neurodegenerative disease, infectious disease, lung disease, heart and vascular disease, metabolic disease, and cancer, wherein the therapeutic ozone agent is administered in a therapeutically effective amount, which can convert carbon monoxide to carbon dioxide, thereby treating or preventing the disease in a patient.. .

Uniform chest compression cpr

An elevation device for the performance of cpr includes a base and a support coupled to the base that is configured to incline relative to the base so as to bend an individual at the individual's waist, thereby elevating an individual's heart, head, and shoulders relative to horizontal. The elevation device includes a chest compression device coupled with the support.

Methods of repositioning a transcatheter heart valve after full deployment

A device for repositioning an implant within a lumen of a subject including (a) a catheter having forward and rearward ends and a collapsible and expansible stop element mounted adjacent the forward end of the catheter, the stop element being adapted to engage a wall of the lumen when expanded and to provide one or more passages extending from a rear side of the stop element to a forward side of the stop element when the stop element is expanded and engaged with the wall of the lumen and (b) one or more snares, each snare having engagement features, the stop element and the snares being constructed and arranged so that the snares can be positioned extending through the one or more passages with their engagement features forward of the stop element.. .
St. Jude Medical, Cardiology Division, Inc.

Implantable device for improving or treating a heart valve insufficiency

The invention relates to an implantable device for improving or treating a heart valve insufficiency, comprising a closure body (1) and at least one anchoring element fastened thereto, by means of which the closure body (1) can be fastened in the heart, preferably in the atrium of the heart, in which the anchoring element comprises a plurality of contact strips (2) extending between the closure body (1) and a shared connecting element (3) which is spaced from the closure body (1), wherein, due to a shape change of the contact strips (2), the connecting element (3) can be brought into a first and a second position each spaced from the closure body, wherein, in the first position, the connecting element (3) is spaced farther apart from the closure body (1) than in the second position, and in the second position, the connecting element (3) is arranged between the contact strips (2).. .
Coramaze Technologies Gmbh

Fixation devices, heart valve leaf repair

Devices, systems and methods for repairing a valve in a patient's heart includes a two or more fixations devices, each fixation device being attachable to the free end of a target tissue, such as a valve leaflet, the fixation devices being coupled together by a coupling device capable of repositioning and coupling the fixation devices in order to re-position the free ends of the valve leaflets.. .
Abbott Cardiovascular Systems Inc.

Cardiac implant delivery system

The present disclosure relates to delivery systems for delivering and deploying interventional devices to a targeted area within a body, such as delivering a replacement heart valve to a targeted heart valve. A delivery device includes a steerable catheter and a replacement valve delivery system positioned within the steerable catheter and configured to be translatable within the steerable catheter.
Evalve, Inc.

Stent features for collapsible prosthetic heart valves

A prosthetic heart valve includes a stent having an expanded condition and a collapsed condition. The stent includes a plurality of distal cells, a plurality of proximal cells, a plurality of support struts coupling the proximal cells to the distal cells, and at least one support post connected to a plurality of proximal cells.
St. Jude Medical, Llc

Prosthetic heart valve having leaflet inflow below frame

Embodiments of a prosthetic heart valve are disclosed. An implantable prosthetic valve can include an annular frame having an inflow end, an outflow end and a central longitudinal axis extending from the inflow end to the outflow end.
Edwards Lifesciences Corporation

Heart valve bioprosthesis and manufacturing method thereof

A heart valve bioprosthesis (100) and a manufacturing method thereof are provided. The heart valve bioprosthesis (100) comprises: a support frame (1), valve leaflets (2) and a valve auxiliary structure.
Hangzhou Jiahezhongbang Biotechnology Co., Ltd.

Aligning a cardiac model

A method (94) for aligning a cardiac model can include receiving (95) an initial position signal from three position sensors (17, 39, 40) disposed along a distal end of a coronary sinus catheter (13) positioned in a coronary sinus (41) of a heart (10). The method (94) can include receiving (96) a subsequent position signal from the three position sensors (17, 39, 40).
St. Jude Medical, Cardiology Division, Inc.

Adjustable heart valve implant

Systems and methods are provided for repairing a heart valve, such as a mitral, tricuspid or aortic valve, using an adjustable and removable implant that can be delivered to the heart through the apex in a simplified and non-invasive manner. The implant can include a prosthetic valve portion coupled to a proximal end of a shaft, and an anchor portion coupled to a distal end of the shaft.

Ultrasound doppler monitoring system

The disclosure is directed to a novel doppler ultrasound system and method for monitoring physiological parameters, such as blood flow and heart rate in which signal clarity and accuracy is improved by actively filtering out system, environmental and background signal noise.. .
Huntleigh Technology Limited

Ultrasound imaging apparatus and controlling the same

In accordance with one aspect of the present disclosure, an ultrasound imaging apparatus comprising: a display portion configured to display an ultrasonic image of a heart of an object; an input portion configured to receive a command for setting a region of interest (roi) of the displayed ultrasonic image of the heart; and a controller configured to set the roi of the ultrasonic image of the heart based on the command for setting the roi input through the input portion and control at least one image of the set roi and the ultrasonic image of the heart to be displayed together on the display portion.. .
Samsung Medison Co., Ltd.

Intra-cardiac echocardiography with magnetic coupling

This document provides devices and methods for interventional treatment of heart conditions. For example, this document provides devices and methods that enhance intra-cardiac echocardiography visualization of interventional devices such as trans-septal puncturing needles..
Mayo Foundation For Medical Education And Research

Contactless blood pressure monitoring of a patient

Contactless blood pressure monitoring, includes: illuminating a blood vessel of a patient with infrared (‘ir’) light; receiving, by an ir camera through a polarizing filter, ir light reflected by the patient; capturing at a time based on a heartrate of the patient, a first ir image of the blood vessel of the patient when the blood vessel is distended; determining, from the first image, a maximum diameter of the blood vessel; capturing at a time based on the heartrate of the patient, a second ir image of the blood vessel of the patient when the blood vessel is contracted; determining, from the second ir image, a minimum diameter of the blood vessel; and calculating blood pressure of the patient in dependence upon the maximum and minimum diameters of the blood vessel.. .
International Business Machines Corporation

Contactless blood pressure monitoring of a patient

Contactless blood pressure monitoring, includes: illuminating a blood vessel of a patient with infrared (‘ir’) light; receiving, by an ir camera through a polarizing filter, ir light reflected by the patient; capturing at a time based on a heartrate of the patient, a first ir image of the blood vessel of the patient when the blood vessel is distended; determining, from the first image, a maximum diameter of the blood vessel; capturing at a time based on the heartrate of the patient, a second ir image of the blood vessel of the patient when the blood vessel is contracted; determining, from the second ir image, a minimum diameter of the blood vessel; and calculating blood pressure of the patient in dependence upon the maximum and minimum diameters of the blood vessel.. .
International Business Machines Corporation

Wearable device for healthcare and method thereof

The present invention relates to a wearable device for healthcare and method for using the device. More specifically, the wearable device is worn on a finger for measuring the health data of the user, selected from one or more of heart rate, blood oxygen saturation, heart rate variability.
Belun Technology Company Limited

Method and medical device for discriminating between a supraventricular tachycardia and a ventricular tachycardia

A method for automatically discriminating between a supraventricular tachycardia event and a ventricular tachycardia event is provided. The method includes sensing a first cardiac signal using a first electrode pair and a second cardiac signal using a second electrode pair during a heartbeat, applying a first algorithm to the first cardiac signal to determine whether the first cardiac signal is indicative for a supraventricular tachycardia or indicative for the ventricular tachycardia; applying a second algorithm to the second cardiac signal to determine whether the second cardiac signal is indicative for the supraventricular tachycardia or indicative for the ventricular tachycardia, the second comparison algorithm being different from the first comparison algorithm; and assigning to a heartbeat-specific indicator a first value indicative for the ventricular tachycardia when at least one of the first cardiac signal and the second cardiac signal have been determined to be indicative tor the ventricular tachycardia..
Medtronic, Inc.

Wearable device

A wearable device is provided. The wearable device according to one embodiment of the present invention includes a body member including a heartbeat sensor, a first band member and a second band member respectively coupled to both ends of the body member, and a flexible battery having a portion accommodated inside the body member and both remaining ends accommodated inside the first band member and the second band member..
Amogreentech Co., Ltd.

Ornamental sweetpotato plant named 'ncornsp-021shjb'

‘ncornsp-021shjb’ is a moderately compact, to compact, non-twining, slightly upright variety producing many short shoots. It is distinguishable from other cultivars by its purple heart shaped leaves that are entire with a cordate base; a moderately compact to compact habit and semi-erect mounding plant architecture.
Koppe Royalty B.v.

Ornamental sweetpotato plant named 'ncornsp-020bwgwe'

‘ncornsp-020bwgwe’ is a compact, non-twining, upright variety producing many short shoots. It is distinguishable from other cultivars by its yellow green heart shaped leaves with dentate to serrate irregular projecting points (i.e.
Koppe Royalty B.v.

Method and device for audio recording

An acquisition system includes a processor, one or more sensors operatively coupled to the processor where the one or more sensors acquire at the ear, on the ear or within an ear canal, one or more of acceleration, blood oxygen saturation, blood pressure or heart-rate, and the one or more sensors configured to monitor a biological state or a physical motion or both for an event. The event can be a detection of a discrepancy when compared with a set of reference data by the one or more sensors or the biological state or the event can be one of a detection of an abrupt movement of a headset operatively coupled to the processor, a change in location of an earpiece operatively coupled the processor, a touching of the headset, a recognizing of a voice command, a starting or ending of a phone call, or a scheduled time..
Staton Techiya Llc

Medical device

A medical apparatus is provided that includes an implantable element, in particular a heart pump, and a control unit for the implantable element, which control unit is connected to the implantable element by means of a first connection. The problem of arranging an antenna of a radio module on the control unit expediently and favourably is solved in that the control unit is configured for arrangement outside the patient's body and has a predetermined orientation relative to the patient's body and has a radio module, wherein an antenna of the radio module is arranged in such a way that the region in which the patient's body is intended to be positioned, as considered from the control unit, is shielded from the antenna at least in part by electromagnetically shielding, in particular electrically conductive parts of the control unit or housing thereof..
Berlin Heart Gmbh

Histomorphometric classifier to predict cardiac failure from whole-slide hematoxylin and eosin stained images

Methods, apparatus, and other embodiments predict heart failure from wsis of cardiac histopathology using a deep learning convolutional neural network (cnn). One example apparatus includes a pre-processing circuit configured to generate a pre-processed wsi by downsampling a digital wsi; an image acquisition circuit configured to randomly select a set of non-overlapping rois from the pre-processed wsi, and configured to provide the set of non-overlapping rois to a deep learning circuit; a deep learning circuit configured to generate an image-level probability that a member of the set of non-overlapping rois is a failure/abnormal pathology roi using a cnn; and a classification circuit configured to generate a patient-level probability that the patient from which the region of tissue represented in the wsi was acquired is experiencing failure or non-failure based, at least in part, on the image-level probability..
Case Western Reserve University

Therapeutics targeting igfbp7 for the treatment or prevention of heart failure and metabolic diseases

Insulin-like growth factor-binding protein 7 (igfbp7) has been identified herein as a therapeutic target for the treatment or prevention of heart diseases, metabolic diseases, and other related disease or conditions. Igfbp7 inhibitors having igfbp7 expression and/or activity reducing properties are described herein.
Ottawa Heart Institute Research Corporation

Antigen-binding proteins that antagonize leptin receptor

The present invention provides antibodies and antigen-binding fragments of antibodies that bind to leptin receptor (lepr), and methods of using the same. According to certain embodiments, the invention includes antibodies and antigen-binding fragments of antibodies that bind lepr and antagonize lepr signaling.
Regeneron Pharmaceuticals, Inc.

Benzothiazole or benzoxazole compounds as sumo activators

Provided are sumo activators, which can enhance sumoylation of serca2a, which are useful in the treatment of heart failure, cardiovascular diseases, cancer, neurodegenerative disorders, viral infection, bacterial infection, liver disease, inflammation, and other diseases.. .
Icahn School Of Medicine At Mount Sinai

System and anatomical mapping of tissue and planning ablation paths therein

Methods for ablating tissue in a patient having atrial fibrillation comprise advancing an elongate flexible shaft through a patient's vasculature into a chamber of a heart. The elongate flexible shaft has an energy source and a sensor.
Vytronus, Inc.

Implantable medical device for atrial deployment

An implantable medical device (imd) may be deployed within a patient's right atrium at a location near a right atrial appendage of the patient's heart in order to pace the patient's heart and/or to sense electrical activity within the patient's heart. In some cases, an imd may be implanted within the right atrial appendage.
Cardiac Pacemakers, Inc.

Systems, devices, and methods for setting cardiac pacing pulse parameters for a cardiac pacing device

Systems, devices, and methods for pacing a heart of a patient are disclosed. A device may include a leadless cardiac pacemaker (lcp) that includes a power supply, a pair of electrodes, and a controller operably connected to the electrodes and the power supply.
Cardiac Pacemakers, Inc.

Method and monitoring tissue fluid content for use in an implantable cardiac device

Techniques for using multiple physiological parameters to provide an early warning for worsening heart failure are described. A system is provided that monitors a multiple diagnostic parameters indicative of worsening heart failure.
Medtronic, Inc.

Cardiac device acclimation profile

This document discusses, among other things, systems and methods to acclimate a patient to therapy from an implantable medical device. For instance, an implantable medical device can include pulse generation circuitry, sensing circuitry, and a controller.
Cardiac Pacemakers, Inc.

Neurostimulation and recording of physiological response for the treatment of chronic cardiac dysfunction

Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone.
East Tennessee State University

System and rate modulated cardiac therapy utilizing a temperature senor

A cardiac rhythm management system provides an increase in pacing rate as a combination of responses to three characteristics of a relative-temperature signal: a dip, a positive slope, and a positive magnitude. The relative-temperature signal is the difference between a short-term and a long-term temperature average.
Pacesetter, Inc.

Chordae tendineae management devices for use with a valve prosthesis delivery system and methods of use thereof

Embodiments hereof relate to methods of delivering a valve prosthesis to an annulus of a native valve of a heart, the native valve having chordae tendineae. A chordae management catheter is positioned within a ventricle of the heart, the chordae management catheter having a displacement component at a distal end thereof.
Medtronic Vascular, Inc.

Integrated stroboscopic eyewear for sensory training

A wireless, programmable and customizable, integrated stroboscopic, eyewear device used as a training tool to enhance the user's sensory processing systems and overall neuro capability (including the underlying pyscho-motor functions). This device functions to elevate and improve the user's perceptual and cognitive processing skills and further measures and collects sensory data from the user during training including heart rate and other bio statistics.
Blw Ip, Llc

Cartridge and increasing myocardial function

The present invention relates to a cytopheretic cartridge for use in treating and/or preventing inflammatory conditions that affect myocardial function and to related methods. The cartridge can be used in treating a subject with myocardial dysfunction, such as a subject with chronic heart failure and/or acute decompensated heart failure..
Cytopherx, Inc.

Carbohydrate composition extracted from panax ginseng and its use in the treatment of ischemic conditions

Methods of treating a subject suffering from an ischemic condition and of preventing an ischemia-reperfusion injury in a subject suffering from an ischemic condition, particularly, but not exclusively ischemic heart disease and the subject is in particular a human, includes administering an effective amount of a carbohydrate composition extracted from panax ginseng to the subject. The carbohydrate composition of the present invention extracted from panax ginseng shows exceptional cardio-protective effect and, thus, provides a highly advantageous and highly promising treatment option for treatment of ischemic conditions and prevention of ischemia-reperfusion injury.
Macau University Of Science And Technology

Bisphosphonate compositions and methods for treating heart failure

The present invention provides for methods and compositions for treating and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, functional analogue or a pharmaceutically effective salt thereof.. .
Duke University

Sacubitril-valsartan dosage regimen for treating heart failure

The present invention relates to sacubitril-valsartan dosage regimens for the treatment of heart failure in a patient.. .
Novartis Ag

Devices for adjusting the curvature of cardiac valve structures

An interventional curvature device for temporarily adjusting the structure of a heart during a heart valve repair procedure in order to enhance the effectiveness of the heart valve repair procedure. The curvature device is adjustable between a collapsed configuration with a profile suitable for delivery of the device to a coronary sinus and great cardiac vein of a patient, and an expanded configuration for lodging of the device at the coronary sinus and great cardiac vein.
Evalve, Inc.

Medical device, kit and constricting tissue or a bodily orifice, for example, a mitral valve

A device, kit and method may employ an implantable device (e.g., annuloplasty implant) and a tool to implant such. The implantable device is positionable in a cavity of a bodily organ (e.g., a heart) and operable to constrict a bodily orifice (e.g., a mitral valve).
Kardium Inc.

Prosthetic heart valve delivery apparatus

Certain embodiments of the present disclosure provide a prosthetic valve (e.g., prosthetic heart valve) and a valve delivery apparatus for delivery of the prosthetic valve to a native valve site via the human vasculature. The delivery apparatus is particularly suited for advancing a prosthetic heart valve through the aorta (i.e., in a retrograde approach) for replacing a diseased native aortic valve.
Edwards Lifesciences Corporation

Mitral heart valve storage and handling system

An improved holder and storage system for a tissue-type prosthetic mitral heart valve that constricts the commissure posts of the valve and prevents suture looping. A rod axially movable relative to the holder tensions lengths of attachment sutures that extend between the commissure post tips to create a tent and flex the tips inward, thus helping to prevent looping of any of an array of pre-implanted sutures around the leading tips during delivery of the valve.
Edwards Lifesciences Corporation

Leaflet engagement elements and methods for use thereof

The present invention relates to apparatus for methods for endovascularly replacing a patient's heart valve. The apparatus includes an expandable anchor with leaflet engagement elements on the proximal end of the anchor and a replacement valve.
Boston Scientific Scimed, Inc.

Transcatheter valve prosthesis

A heart valve system, the system including a radially self-expandable tubular body and a valve. The tubular body having an inflow end and an outflow end, and the tubular body including a proximal-most end at the inflow end and a distal-most end at the outflow end.
Highlife Sas

Transcatheter valve prosthesis

A heart valve system, the system including a radially self-expandable tubular body and a valve. The tubular body having an inflow end and an outflow end such that the outflow end includes a proximal section and a plurality of beams.
Highlife Sas

Transcatheter valve prosthesis

A heart valve system, the system including a radially self-expandable tubular body, a valve, and a tubular fabric. The tubular body having an inflow end and an outflow end.
Highlife Sas

Transcather valve prosthesis

A heart valve system, the system including a radially self-expandable tubular body, a valve, and a tubular fabric. The tubular body having an inflow end and an outflow end and including a plurality of struts with at least one motion buffer component integrated in the tubular body.
Highlife Sas

Transcatheter valve prosthesis

A heart valve system, the system including a radially self-expandable tubular body, a valve, and a tubular fabric. The tubular body having an inflow end and an outflow end.
Highlife Sas

Prosthetic valves, frames and leaflets and methods thereof

Described embodiments are directed toward prosthetic heart valve leaflets of particular shapes that control bending character. In accordance with an embodiment, a prosthetic heart valve comprises a leaflet frame having a generally tubular shape with attached film.
W. L. Gore & Associates, Inc.

Mitral valve prosthesis with atrial anchoring

A method of treating a mitral valve without open-heart surgery is disclosed. An expandable prosthesis comprises an anchoring portion and an occluding member coupled to the anchoring portion.
Edwards Lifesciences Ag

Methods of delivery of heart valves

A prosthetic heart valve can include a valve frame having a wireform portion and a stent portion. The wireform and stent portions can be undetachably coupled together via a plurality of upright struts so as to form a one-piece prosthetic heart valve frame.
Edwards Lifesciences Corporation

Heart valve delivery system with valve catheter

An assembly for treating a native valve in a human heart includes a prosthetic heart valve having an expandable frame and a valvular structure. The assembly also includes a tubular sleeve and a valve catheter disposed within the sleeve.
Edwards Lifesciences Corporation

Valve delivery system having an integral displacement component for managing chordae tendineae in situ and methods of use thereof

Embodiments hereof relate methods of delivering a valve prosthesis to an annulus of a native valve of a heart. A valve delivery system is introduced into a ventricle of the heart via a ventricular wall of the heart.
Medtronic Vascular, Inc.

Systems and methods for reduction of atrial fibrillation

Embodiments of the present invention are directed to ablation catheter systems configured, for example, to ablate tissue adjacent an ostium of the pulmonary vein in a left atria of a heart. In one embodiment, an ablation catheter system includes a handle and a catheter coupled to the handle defining a lumen extending through a length of the catheter, the catheter including a distal end thereof.
Coherex Medical, Inc.

Lesion assessment by dielectric property analysis

Devices and methods for tissue lesion assessment and/or creation based on dielectric properties are disclosed. In some embodiments, one or more probing frequencies are delivered via electrodes including an electrode in proximity to a tissue (for example, myocardial tissue).
Navix Internationl Limited

Patent foramen ovale closure method

The present invention relates to devices for closing a passageway in a body, for example a patent foramen ovale (pfo) in a heart, and related methods of using such closure devices for closing the passageway. The method includes introducing a mechanical closure device into an atrium of the heart and transeptally deploying the closure device across the interatrial septum to provide proximation of the septum secundum and septum primum..
Cordis Corporation

Data processing assessing a condition of a myocardium

The invention concerns a data processing apparatus for processing t-wave information or st-segment information from an electrical signal from a myocardium of a heart of a human or animal, for an assessment of a condition of at least a part of the myocardium or the whole myocardium, characterized in that the data processing apparatus is configured to derive a t-wave deviation value from a difference of at least two t-wave parameters or st-segment parameters, wherein each of the two parameters belongs to another t-wave or st-segment from the same heart. Further, an assessment apparatus for assessing the condition of at least a part of a myocardium of a heart of an individual human or animal, a method for providing data for an assessment of a condition of at least a part of a myocardium of a heart of a human or an animal, wherein the method includes processing t-wave information from an electrical signal from at least a part of a myocardium and a diagnosis method for diagnosing a condition or a disease of a heart are proposed.
Alekseev Alekseev Siegle Röder Gbr

Method for detecting heart rate and heart rate monitoring device using the same

A method of controlling an emitted light strength for a heart rate monitoring (hrm) device is disclosed. The method includes steps of obtaining a surface condition of a skin of a user; determining an emitted strength of an emitted light according to the surface condition of the skin; and determining the heart rate of the user according to the emitted light with the emitted strength..
Htc Corporation

Sowing unit for a sowing machine

A sowing unit for a sowing machine that comprises a coupling device, a joint device provided between the coupling device and a support device with separate fastening points for functional components, and a sowing heart which meters a work product is disclosed. The support device has a proximal support arm, which couples to the joint device, and a distal support arm, which, on a side of the proximal support arm facing away from the joint device, extends away from said proximal support arm, and on which the sowing heart is arranged laterally in the area of an assembly section in such a way that a rear side of the sowing heart is arranged so as to be located opposite to the assembly section of the distal support arm and a front side of the sowing heart is arranged so as to be unobstructed by the support device..
Kverneland As

Devices for reducing left atrial pressure, and methods of making and using same

A device for regulating blood pressure between a patient's left atrium and right atrium comprises an hourglass-shaped stent comprising a neck region and first and second flared end regions, the neck region disposed between the first and second end regions and configured to engage the fossa ovalis of the patient's atrial septum; and a one-way tissue valve coupled to the first flared end region and configured to shunt blood from the left atrium to the right atrium when blood pressure in the left atrium exceeds blood pressure in the right atrium. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits.
Longwood Gardens, Inc.

Method for an audio/video live broadcast in an html5-based browser

The invention discloses a method for an audio/video live broadcast in a html5-based browser. There is a webrtc-based communication channel built between a client end and a host end to do transmission for a video stream and an audio stream as well as a message transmission.
Shanghai Hode Information Technology Co.,ltd.

Multilevel intelligent interactive mobile health system for behavioral physiology self-regulation in real-time

An automated method for personal health management of a user having a personal user profile, the method including repeatedly measuring a plurality of health parameters by a mobile electronic device, the health parameters including a heart rate variability, a blood pressure, a motion activity, and a weight of the user, calculating a base line dataset by the computing device for each one of the plurality of health parameters for a predetermined period of time, comparing recently measured health parameters from the step of repeatedly measuring with the base line dataset, providing on a display that is operatively connected to the computing device a first raw feedback on a health performance of the user based on the step of comparing, repeatedly prompting the user to answer contextual questions, the contextual questions related to at least one of physical, mental, emotional, and behavioral status of the user, and generating a second detailed feedback based on the personal user profile, the baseline data set, the measured health parameters, and a given context, to determine values for a plurality of health segments, and providing the second detailed feedback to the display of the user, based on a request by the user that includes the given context and data of the plurality of health segments.. .
Talislife Sàrl

Method for expressing social presence of virtual avatar, using change in pupil size according to heartbeats, and system employing same

A method of producing a realistic virtual avatar by using a change in a pupil size according to heartbeats. The method tracks and records, in real time, a change in a pupil size of the actual user according to heartbeats of the actual user and applies the same to an eye model of a virtual avatar so as to synchronize the pupil size of the eye model with the pupil size of the actual user..
Sangmyung University Seoul Industry-academy Cooperation Foundation

Method for diagnosis and prognosis of chronic heart failure

Present application relates to methods for determining whether a subject has heart failure or is at risk of having heart failure, specifically that of heart failure with reduced left ventricular ejection fraction (hfref) and a heart failure with preserved left ventricular ejection fraction (hfpef), comprising determining the level of selected mirna(s) observed in a sample obtained from the subject and wherein an altered level of the mirna(s) compared to control indicates that the subject has heart failure or is at risk of developing heart failure. Also encompassed are methods of determining an altered risk of death or disease progression to hospitalization and death based on alteration of selected mirnas in a sample from the subject and kits thereof..
National University Of Singapore

Compositions and methods for the treatment of carboxyhemoglobinemia

Described herein is a new antidote for the rapid elimination of carbon monoxide from hemoglobin, including brain, heart, and red cell hemoglobin. The disclosed therapy involves the use of modified human globins, particularly neuroglobins modified at residue 64 and cytoglobins modified at residue 81, which bind carbon monoxide with extremely high affinity.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education

Sk and ik channel agonists for treatment of heart failure

The present invention provides compounds that are improved potassium channel agonists. Pharmaceutical compositions including a pharmaceutically acceptable carrier and a compound of the present invention are also provided.
The Trustees Of Columbia University In The City Of New York

Systems and methods for activity level pacing

Systems, devices, and methods for pacing a heart of a patient are disclosed. An illustrative method may include determining a motion level of the patient using a motion sensor of an implantable medical device secured relative to a patient's heart, and setting a pacing rate based at least in part on the patient's motion level.
Cardiac Pacemakers, Inc.

Systems and methods for activity level pacing

Systems, devices, and methods for pacing a heart of a patient are disclosed. An illustrative method may include determining a motion level of the patient using a motion sensor of an implantable medical device secured relative to a patient's heart, and setting a pacing rate based at least in part on the patient's motion level.
Cardiac Pacemakers, Inc.

Use of a separate device in managing the pace pulse energy of a cardiac pacemaker

A medical system may include a first medical device such as a leadless cardiac pacemaker (lcp) that is configured to pace a patient's heart and a second medical device that is configured to have a capture threshold capability. The second medical device may monitor the patient's heart to ascertain whether the pacing pulses from the first medical device are capturing the heart, and to send the first medical device instructions to alter an energy level of subsequent pacing pulses..
Cardiac Pacemakers, Inc.

Responsive neurostimulation for the treatment of chronic cardiac dysfunction

Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone.
East Tennessee State University

Catheter system for acute neuromodulation

A neuromodulation system includes a first therapy element adapted for positioning within a superior vena cava, and a second therapy element adapted for positioning within a pulmonary artery. The first therapy element is carried on a first elongate flexible shaft, and the second therapy element is carried on a second elongate flexible shaft.
Interventional Autonomics Corporation

Systems for establishing supplemental blood flow in the circulatory system

A blood circulation assist system comprising an inflow cannula having a lumen and an insertion device configured to be received therein and to facilitate insertion of a portion of the inflow cannula into a heart chamber. The insertion device includes a shaft having distal and proximal end portions and a plurality of lumens.
Circulite, Inc.

Enalapril compositions

Provided herein are stable enalapril powder compositions for oral liquid formulation. Also provided herein are methods of using enalapril oral liquid formulations for the treatment of certain diseases including hypertension, heart failure and asymptomatic left ventricular dysfunction..
University Of Kansas

Heart valve prosthesis delivery delivery of heart valve prosthesis with introducer sheath

The present disclosure relates to a delivery system, a catheter system and a method for the minimally invasive application of prostheses to an individual in need thereof and a method for loading a prosthesis onto a catheter system and/or a delivery system.. .
Jenavalve Technology, Inc.

Implant

An implant for implantation around a circumferential tissue structure in a heart, includes a flexible elongated component having a longitudinal axis and a first distal end portion, a second distal end portion and an intermediate portion extending between the first and second distal end portions, and an inner lumen extending longitudinally between the first and second distal end portions and through the intermediate portion; and a locking member for allowing the first distal end portion to be fixedly connected to the second distal end portion so as to provide the elongated component as a closed loop. The first distal end portion is provided with a first distal opening which connects the inner lumen with an outside of the component.
Highlife Sas

Prosthetic mitral valve

A prosthetic heart valve having an inflow end and an outflow end includes a stent having a collapsed condition, an expanded condition, and cells arranged in circumferential rows. The stent has an anterior side configured to be disposed adjacent an anterior native valve leaflet and a posterior side configured to be disposed adjacent a posterior native valve leaflet.
St. Jude Medical, Cardiology Division, Inc.

Prosthetic mitral valve holders

Valve holders and introducers for delivering a prosthetic heart valve to an implant site are in various embodiments configured to facilitate insertion of prosthetic valves through small incisions or access sites on a patient's body. The valve holders can also be configured to reduce or eliminate the occurrence of suture looping or other damage to the prosthetic valve during implantation.
Edwards Lifesciences Corporation

Prosthetic heart valves with elastic support structures and related methods

Prosthetic heart valves having elastic leaflets and an elastic support structure are described. The support structure can exhibit a precursory transition from the closed position to the open position.
Foldax, Inc.

Replacement valve and anchor

Apparatus for endovascularly replacing a patient's heart valve, including: a replacement valve adapted to be delivered endovascularly to a vicinity of the heart valve; an expandable anchor adapted to be delivered endovascularly to the vicinity of the heart valve; and a lock mechanism configured to maintain a minimum amount of anchor expansion. The invention also includes a method for endovascularly replacing a patient's heart valve.
Boston Scientific Scimed, Inc.

Replacement valve and anchor

Apparatus for endovascularly replacing a patient's heart valve, including: a replacement valve adapted to be delivered endovascularly to a vicinity of the heart valve; an expandable anchor adapted to be delivered endovascularly to the vicinity of the heart valve; and a lock mechanism configured to maintain a minimum amount of anchor expansion. The invention also includes a method for endovascularly replacing a patient's heart valve.
Boston Scientific Scimed, Inc.

Supra and sub-annular mitral valve delivery system

Methods are described herein for delivering a replacement mitral valve to a native mitral valve location. In one method, ventricular anchors of the replacement mitral valve are released and allowed to reverse orientation while positioned in the left atrium of a human heart.
Edwards Lifesciences Corporation

Contact quality assessment by dielectric property analysis

Devices and methods for assessing tissue contact based on dielectric properties and/or impedance sensing are disclosed. In some embodiments, one or more probing frequencies are delivered via electrodes including an electrode in proximity to a tissue (for example, myocardial tissue).
Navix International Limited

Patient-specific virtual intervention laboratory to prevent stroke

The present application relates to systems and methods for performing a computerized cardiac simulation for at least one of diagnosis, risk assessment or treatment planning including: receiving, by a computer, a plurality of three-dimensional cardiac images of a subject's heart such that each three-dimensional cardiac image corresponds to a different phase of a single cardiac cycle of the subject's heart; modeling structure, using the computer, of the left atrium of the subject as a function of time using the plurality of three-dimensional cardiac images of the subject's heart; modeling blood flow, using the computer, within, into and out of the left atrium of the subject as a function of time using computational fluidic dynamics and using structure of said left atrium obtained from at least one of said plurality of three-dimensional cardiac images or said modeling structure of said left atrium; simulating at least one of time dependent structural function or time-dependent blood flow of said left atrium using results from said modeling structure and said modeling blood flow for a selected period of time; and providing information to a user from said simulating for use in at least one of diagnosis, risk assessment or treatment planning for a physiological effect related to function of said left atrium of the subject.. .
The Johns Hopkins University

Method and detecting instantaneous fetal heart rate of doppler fetal heart sound based on time-frequency analysis

The present disclosure relates to medical monitoring and provides a method and an apparatus for detecting an instantaneous fetal heart rate of a doppler fetal heart sound based on time-frequency analysis. The method comprises: pre-processing a doppler fetal heart sound using a band pass filter; applying time-frequency analysis to the pre-processed ultrasound doppler fetal heart sound, so as to obtain a time-frequency graph of the ultrasound doppler fetal heart sound by stft for simple and fast calculation; applying a cross correlation method to obtain an instantaneous of the fetal heart sound by: selecting a characteristic band from the time-frequency graph of the doppler fetal heart sound, selecting a characteristic template based on a priori knowledge of the heart sound signal, calculating a cross-correlation function between the characteristic band and the characteristic template to plotting a cross correlation curve; and calculating an instantaneous heart rate of the ultrasound doppler fetal heart sound signal by calculating intervals between peaks of the cross correlation curve.
Guangdong University Of Technology

Heart activity detector for early detection of heart diseases

In an embodiment, a heart activity detector is provided. In the embodiment, the heart activity detector is comprised of a multi-channel stethoscope connected to one or more processors.
Awaire Inc.

Wearable monitoring device

A system, method, and device for monitoring a physiological characteristic and/or response of a user includes a wearable monitoring device for displaying a status level of a physiological characteristic and/or response. When attached to or against the user's body, the wearable monitoring device includes an optical signal assembly configured to generate an optical signal based on a reflection or transmission of light from a detected travel of blood and/or pulse wave of the user and received by one or more sensors disposed along the user's extremity.
Garmin Switzerland Gmbh

Electrophysiological mapping catheter

Disclosed are various examples and embodiments of a cardiac mapping catheter configured for electrophysiological (ep) mapping and suitable for intravascular insertion in a patient's heart, and methods of making same. The cardiac mapping catheter comprises a plurality support arms having electrodes disposed thereon.
Ablacon Inc.

Medical information bracelet

A medical information bracelet for storing and retrieving medical information from a user. The medical information bracelet includes a housing disposed on an elongated strap, wherein the housing comprises a visual display screen and a non-transitory computer readable medium.

System and monitoring and treating arrhythmia and cardiac function via the intrinsic cardiac nervous system

The present invention includes systems and methods for measuring, monitoring and treating arrhythmia and cardiac function via the intrinsic cardiac nervous system. The systems and methods compare neural signatures of the intrinsic cardiac nervous system that are associated with both healthy and diseased myocardial tissue to identify and target afferent intrinsic cardiac neurons for which signaling has been affected by diseased cardiac tissue.
The Regents Of The University Of California

Systems and methods for measuring cardiac strain

A method for rapid computation of three-dimensional displacement and lagrange strain in a high resolution filed of phase data obtained with displacement encoding with stimulated echoes (dense) in magnetic resonance images of the myocardium. The method includes semi-automated segmentation of a region of a heart, phase unwrapping the images in three dimensions, and a custom radial point interpolation method (rpim).
Washington University

Devices, systems, and methods for epicardial cardiac monitoring

Devices, systems, and methods for remotely monitoring physiologic cardiovascular data are disclosed. At least some of the embodiments disclosed herein provide access to the external surface of the heart through the pericardial space for the delivery of the sensor to the epicardial surface of the heart.
Cvdevices, Llc

Selection of preferred content

A user can specify particular news, weather, traffic, or other perishable content received on a particular internet radio station or other media channel. The user can customize the station so that wherever the user is currently located, he can receive perishable content related to a preferred geographic location or other category.
Iheartmedia Management Services, Inc.

Technique simulator

A procedure simulator that includes an animal heart to which a first balloon is inserted into a left ventricle of the heart and to which a second balloon is inserted into a right ventricle of the heart. A pump system makes the first balloon and the second balloon expand and contract via an operating fluid (l).
Terumo Kabushiki Kaisha

System and a blood flow simulator

A blood flow simulator generates a compression and expansion in a test fluid that emulates the pressure waveform created by a heartbeat in blood flow. The blood flow simulator stores a plurality of pressure waveform files that include actual data recorded from a heartbeat, arterial pressure waveform, or venous pressure waveform.
Sanmina Corporation

Podcast interface

A method of and apparatus for content assembly is provided by which an automation playlist of media events is created and published as a podcast. The publishing includes a podcast automation interface defining: a web syndication format, one or more rss (really simple syndication) channels for the publishing of the podcast, one or more rss (really simple syndication) variables for the publishing of the podcast, a podcast feed, wherein the podcast automation interface is used to create or update a local copy of one or more of: an rss file or a web feed and distribute the podcast over a network..
Iheartmedia Management Services, Inc.

Rules based playlist generation

A playlist can be generated based on a chart or list including ranked media items, e.g. Songs, videos, etc., by automatically including the highest ranked media items to the playlist, but only adding some of the lower ranked media items to the playlist.
Iheartmedia Management Services, Inc.

Detection and identification of a human from characteristic signals

One or more sensors are configured for detection of characteristics of moving objects and living subjects for human identification or authentication. One or more processors, such as in a system of sensors or that control a sensor, may be configured to process signals from the one or more sensors to identify a person.
Resmed Sensor Technologies Limited

Systems and methods for arrhythmia detection

Systems and methods for detecting cardiac arrhythmias such as an atrial fibrillation (af) are described herein. The af detection system includes a sensor circuit to sense a physiological signal, a heartbeat processor to recognize a plurality of beat patterns using cycle length of two more consecutive cardiac cycles.
Cardiac Pacemakers, Inc.

Subcutaneous vascular access assemblies and related devices and methods

Vascular access devices, assemblies, kits, and related methods are disclosed. A vascular access assembly may include a first tubular conduit, a second tubular conduit, and an expandable stent graft that is coupled adjacent to a peripheral end of the second tubular conduit.
Merit Medical Systems, Inc.

Methods and oxygenation and/or co2 removal

Described is an apparatus for oxygenation and/or co2 clearance of a patient, comprising: a flow source or a connection for a flow source for providing a gas flow, a gas flow modulator, a controller to control the gas flow, wherein the controller is operable to: receive input relating to heart activity and/or trachea gas flow of the patient, and control the gas flow modulator to provide a varying gas flow with one or more oscillating components with a frequency or frequencies based on the heart activity and/or trachea flow of the patient.. .
Fisher & Paykel Healthcare Limited

Substrate having an electron donating surface with metal particles comprising palladium on said surface

There is disclosed a substrate with an electron donating surface, characterized in having metal particles on said surface, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of said metal particles is from about 0.001 to about 8 μg/cm2. Examples of coated objects include contact lenses, pacemakers, pacemaker electrodes, stents, dental implants, rupture nets, rupture mesh, blood centrifuge equipment, surgical instruments, gloves, blood bags, artificial heart valves, central venous catheters, peripheral venous catheters, vascular ports, haemodialysis equipment, peritoneal dialysis equipment, plasmapheresis devices, inhalation drug delivery devices, vascular grafts, arterial grafts, cardiac assist devices, wound dressings, intermittent catheters, ecg electrodes, peripheral stents, bone replacing implants, orthopaedic implants, orthopaedic devices, tissue replacing implants, intraocular lenses, sutures, needles, drug delivery devices, endotracheal tubes, shunts, drains, suction devices, hearing aid devices, urethral medical devices, and artificial blood vessels..
Bactiguard Ab

Neuregulin based methods for treating heart failure

The present invention features methods of treating patients with chronic heart failure by administering a neuregulin polypeptide within a dosage range which is both effective and safe.. .
Zensun (shanghai) Science & Technology, Co., Ltd.

Actively controllable stent, stent graft, heart valve and controlling same

A delivery apparatus comprises a handle portion and at least one rotatable drive shaft. The handle portion has an actuation mechanism and a display.
Edwards Lifesciences Cardiaq Llc

Sizing methods for a valved conduit graft

A sizing tool for use in implanting a composite valved conduit having a prosthetic heart valve on a distal end attached to a conduit graft that extends to a proximal end. The tool includes a proximal handle and a distal shaft, a prosthetic heart valve sizer having an axis affixed to a distal end of the shaft, and a conduit graft replica having an axis mounted on the shaft proximal to the heart valve sizer.
Edwards Lifesciences Corporation

Replacement heart valve with diaphragm

A replacement heart valve system may include a delivery sheath and a replacement heart valve. The replacement heart valve may include a mesh anchor member disposed within the delivery sheath in an elongated delivery configuration, the mesh anchor member being expandable to a deployed configuration when unconstrained by the delivery sheath.
Boston Scientific Scimed, Inc.

Low profile heart valve and delivery system

Apparatus for endovascularly replacing a patient's heart valve, including: a delivery catheter having a diameter of 21 french or less; an expandable anchor disposed within the delivery catheter; and a replacement valve disposed within the delivery catheter. The invention also includes a method for endovascularly replacing a heart valve of a patient.
Boston Scientific Scimed, Inc.

Everting heart valve

The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an expandable anchor configured for endovascular delivery to a vicinity of the patient's heart valve.
Boston Scientific Scimed, Inc.

Self-actuating sealing portions for paravalvular leak protection

A prosthetic heart valve for replacing a native valve includes a collapsible and expandable stent having a proximal end and a distal end, and a valve assembly including a plurality of leaflets, the valve assembly being disposed within the stent. The heart valve further includes a first plurality of elongated legs coupled to the stent and transitionable from an extended configuration to a relaxed configuration.
St. Jude Medical, Cardiology Division, Inc.

Replacement valve and anchor

Apparatus for endovascularly replacing a patient's heart valve, including: a replacement valve adapted to be delivered endovascularly to a vicinity of the heart valve; an expandable anchor adapted to be delivered endovascularly to the vicinity of the heart valve; and a lock mechanism configured to maintain a minimum amount of anchor expansion. The invention also includes a method for endovascularly replacing a patient's heart valve.
Boston Scientific Scimed, Inc.

Replacement valve and anchor

Apparatus for endovascularly replacing a patient's heart valve, including: a replacement valve adapted to be delivered endovascularly to a vicinity of the heart valve; an expandable anchor adapted to be delivered endovascularly to the vicinity of the heart valve; and a lock mechanism configured to maintain a minimum amount of anchor expansion. The invention also includes a method for endovascularly replacing a patient's heart valve.
Boston Scientific Scimed, Inc.

Methods and apparatuses for deploying minimally-invasive heart valves

An assembly includes an expandable prosthetic heart valve, a catheter shaft, and a stabilization device. The expandable prosthetic heart valve has a valve body and a plurality of leaflets coupled to the valve body.
Edwards Lifesciences Corporation

Transseptal insertion device

A transseptal insertion device is provided including device housing, a pusher slidably disposed in the device housing and a guide element extending from the pusher. The device housing is configured to be inserted into the right atrium of a patient's heart and the guide element can then be advanced from the device housing and against the cardiac septum to facilitate stable puncturing of the cardiac septum by a needle carried by a catheter inserted through the device housing, to provide access to the left atrium.

Automatic extraction of disease-specific features from doppler images

An automatic extraction of disease-specific features from doppler images to help diagnose valvular diseases is provided. The method includes the steps of obtaining a raw doppler image from a series of images of an echocardiogram, isolating a region of interest from the raw doppler image, the region of interest including a doppler image and an ecg signal, and depicting at least one heart cycle, determining a velocity envelope of the doppler image in the region of interest, extracting the ecg signal to synchronize the ecg signal with the doppler age over the at least one heart cycle, within the region of interest, calculating a value of a clinical feature based on the extracted ecg signal synchronized with the velocity envelope, and comparing the value of the clinical feature with clinical guidelines associated with the clinical feature to determine a diagnosis of a disease..
International Business Machines Corporation

Heart rate and pulse monitoring device

Methods, devices and systems for obtaining heart rate by obtaining apical and non-apical heart rate datum using first and second heart rate monitoring devices. The apical and non-apical heart rate data are input into a heart rate verification module (hrvm) that includes a number of programming instructions for effecting the invention.

Detecting and suppressing noise signals of a differential voltage measuring system

Methods, noise detection devices, and differential voltage measuring systems are provided for detecting noise signals for the purpose of measuring cardiac movements in a patient. In the method, contact is made with the patient by at least two measuring electrodes having at least one associated measuring channel.

Method and heart rate monitoring

A method and apparatus for monitoring heart rate. The method includes receiving a digital heart monitoring signal, determining the integrity of said signal with a “hand detect” signal that confirms electrical connection to the subject, dividing the digital heart monitoring signal into at least one frame, generating a folded correlation value for the center sample in the at least one frame, identify the number of peaks folded correlation values based on amplitude and distance parameters of the digital heart monitoring signal in the at least one frame, removing false peaks and collecting peaks corresponding to a length of time, determining the heart rate based on the identified peaks wherein the identified peaks relate to a minimum distance between valid heart beat peaks based on a heart rate estimate, computing the weighted average of heart rate value based on the number of previous heart rate values..
Texas Instruments Incorporated

Physiological sensor delivery device and method

An intravascular sensor delivery device for measuring a physiological parameter of a patient, such as blood pressure, within a vascular structure or passage. In some embodiments, the device can be used to measure the pressure gradient across a stenotic lesion or heart valve.
Acist Medical Systems, Inc.

Systems, devices, and methods for contact measurement and modulation of material properties

Materials and devices are provided for the sensing and manipulation of biomechanical and physiochemical properties of tissues or tissue surfaces. Examples of use include soft tissues such as skin or adipose tissues or more dense tissues such as muscle or heart or dense tissues such as bone.
Board Of Trustees Of Teh University Of Illinois

System and replacing a heart valve that is diseased owing to inflammation or an infection

The invention relates to a system for replacing a heart valve that is diseased owing to inflammation and/or an infection. The system has: a stent system with at least one expandable stent; and a replacement heart valve which is secured to the at least one stent and has at least two heart valve leaflets.
State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization

Magnetic resonance imaging apparatus and operating the same

A magnetic resonance imaging (mri) apparatus, including a processor and a memory connected to the processor, wherein the processor is configured to control a radio frequency (rf) coil to apply a first pulse sequence to a first slice from among a plurality of slices of an object during a first rr interval of a heart, and acquire a first magnetic resonance (mr) signal corresponding to the first pulse sequence from the rf coil, control the rf coil to apply a second pulse sequence to a second slice from among the plurality of slices during a second rr interval of the heart, and acquire a second mr signal corresponding to the second pulse sequence from the rf coil, reconstruct a first mr image from the first mr signal, and reconstruct a second mr image from the second mr signal.. .
Samsung Electronics Co., Ltd.

Blood pump with separate mixed-flow and axial-flow impeller stages, components therefor and related methods

A rotordynamic pump for delivering continuous flow of fluids, such as blood, is provided. In one embodiment, the pump includes a stator housing having an inlet and an outlet.
Worldheart Corp.

System and crossing a native heart valve with a guidewire

A system for crossing a heart valve with a guidewire includes an advancement motor and a controller. The controller controls when the advancement motor advances and retracts the guidewire.
Medtronic Vascular, Inc.

System for monitoring and controlling sleep

A system for monitoring and controlling a heart rate includes an interface for communicating with a heart rate monitor and a haptic device. The system also includes a processor and memory.
Icon Health & Fitness, Inc.

Transcatheter device and system for the delivery of intracorporeal devices

An intracorporeal device for delivery into a patient is provided. The intracorporeal device includes a proximal end and a distal end.
Nuheart As

A therapeutic gene cocktail for heart regeneration

A combination of active agents selected from a foxm1 enhancer, an id1 enhancer, and a jnk3 inhibitor and the uses thereof in promoting cardiomyocyte proliferation and treating heart diseases in a subject in need of the treatment.. .
Academia Sinica

Heart valve sizing ring and method

A device for measuring heart valve for sizing a heart valve reinforcement ring, includes a handle having a first shaft and a second shaft; an inner ring coupled to the first shaft; an outer ring coupled to the second shaft; and a trigger mechanism configured and arranged to force the inner ring and outer ring together wherein an outer surface of the inner ring engages an inner surface of the outer ring; the inner surface of the outer ring and the outer surface of the inner ring having reciprocal mating surfaces configured and arranged to grip sutures therebetween when coupled together.. .

Apparatus and heart valve repair

A device and method for repairing a mitral valve leaflet 2, 3. The device 10 includes a body 16 having an annular wall 18 and at least one aperture 22 through the annular wall 18.
St. Jude Medical, Inc.

Annuloplasty procedures, related devices and methods

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation.

Device and delivery of an implant through a catheter

Disclosed herein is a delivery system for percutaneous heart valve repair, the delivery system including a steerable sheath configured to provide percutaneous access into a heart and to deliver an implant. The system may also have a steering mechanism configured to manipulate and orient the implant, a ball joint mechanism configured to connect the steerable sheath to the steering mechanism, a main knob assembly configured to advance and retract a multilumen shaft assembly, a stabilizing tool including a plurality of prongs configured to engage the implant within the heart to make an intimate contact with the heart tissue using a stabilizer and a tongue assembly, and a back assembly including: the actuation mechanism, a suture routing mechanism, a tip lock mechanism, and a back cover configured to protect all sutures being cut by mistake..
Valcare, Inc.

Stented prosthetic heart valve delivery system having an expandable bumper

Delivery devices for delivery of a stented prosthetic heart valve. Various delivery devices include an outer sheath assembly including an outer sheath connected to a capsule that is advanced proximally to retain the prosthetic valve, which is secured over an inner shaft assembly of the delivery device.
Medtronic Vascular, Inc.

Transcatheter the delivery of intracorporeal devices

A method is provided for the transcatheter delivery of an intracorporeal device and includes establishing a device delivery pathway in a patient. The device delivery pathway extends at least from an entry point into the patient to an exit point from the patient.
Nuheart As

Delivery system for a valve prosthesis

A heart valve prosthesis and delivery systems are provided for replacing a cardiac valve. The heart valve prosthesis includes a self-expanding frame includes a portion having a crimp that provides additional flexibility to the self-expanding frame in the collapsed configuration..
Medtronic, Inc.

Health monitoring kit

A health monitoring kit includes a package unit, a scale, a display band, and a heart monitor. The package unit includes a base panel with a base face, a first upper panel, and a second upper panel.
Under Armour, Inc.

Aortic leaflet repair using shock wave applicators

Described herein are shock wave devices and methods for the treatment of calcified heart valves. One variation of a shock wave device may comprise an elongated flexible tube carried by a sheath.
Shockwave Medical, Inc.

Deploying and fixating an implant across an organ wall

Implant deployment device for delivering and deploying an implant. Includes: deployment device body for pushing implant in subject's blood vessel, across an interatrial septum and into subject's heart left atrium; and a handle operatively connected to deployment device and having controls assigned to selectively operate positioning of the deployment device, to facilitate determining compression extent of an implant body, and detaching of deployment device from the implant.
Vectorious Medical Technologies Ltd

Cardiac injury device

A device, method, and use of a device for temporary management of a wound, such as a wound in a heart. The device has a shaft, a blood flow blocking membrane at the first end of the shaft for blocking blood flow through the wound, and an abutment member that is mounted to the shaft and is axially movable along the shaft towards and away from the blood flow blocking membrane for abutting the wound and holding the blood flow blocking membrane adjacent the wound.

System and predicting acute cardiopulmonary events and survivability of a patient

A method of producing an artificial neural network capable of predicting the survivability of a patient, including: storing in an electronic database patient health data comprising a plurality of sets of data, each set having at least one of a first parameter relating to heart rate variability data and a second parameter relating to vital sign data, each set further having a third parameter relating to patient survivability; providing a network of nodes interconnected to form an artificial neural network, the nodes comprising a plurality of artificial neurons, each artificial neuron having at least one input with an associated weight; and training the artificial neural network using the patient health data such that the associated weight of the at least one input of each artificial neuron is adjusted in response to respective first, second and third parameters of different sets of data from the patient health data.. .
Nanyang Technological University

Non-invasive monitoring lusitropic myocardial function in relation to inotropic myocardial function

A system and method for non-invasively monitoring the hemodynamic state of a patient by determining on a beat-by-beat basis the ratio of lusitropic function to inotropic function as an index of myocardial well-being or pathology for use by clinicians in the hospital or by the patient at home. In one embodiment of the system a smartphone running an application program that is connected through the internet to the cloud processes electronic signals, first, from an electrocardiogram device monitoring electrical cardiac activity, and second, from a seismocardiogram device monitoring mechanical cardiac activity in order to determine such ratio as an instantaneous measurement of the hemodynamic state of the patient, including such states as sepsis, myocardial ischemia, and heart failure..
The Cooper Health System

System and synchronizing external compression of a limb for increased blood

Embodiments relate to devices, systems and methods of assisting blood flow return to the heart from a limb. The device comprising a wearable garment (115) and a compression apparatus (110) embedded in the garment (115) for applying an external compression according to a compression sequence to a muscle of a limb of a user based on real-time measurements regarding a cardiac cycle having a diastolic phase and systolic phase of the user and real-time measurements of muscle activity.
Lockheed Martin Corporation

Method for processing virtual machine cluster and computer system

The present disclosure provides a method for managing a virtual machine cluster. The method includes: sending, by the first virtual machine, a first heartbeat message to at least two neighboring virtual machines in the n virtual machines, so that the at least two neighboring virtual machines detect the first heartbeat message, where a result of detecting the first heartbeat message is used to determine a status of the first virtual machine, and the first virtual machine establishes a neighbor relationship with the at least two neighboring virtual machines according to the information about the n virtual machines; and detecting, by the first virtual machine as a neighboring virtual machine of a second virtual machine in the at least two virtual machines, a second heartbeat message sent by the second virtual machine..
Huawei Technologies Co., Ltd.

Eyeglasses that measure facial skin color changes

Described herein are systems and methods for detecting a physiological response based on facial skin color changes (fscc) recognizable in images taken with an inward-facing head-mounted visible-light camera (vcamin). Some examples of physiological responses whose manifestation involves fscc include emotional responses (which at times may be hidden to the naked eye), and physiological signals such as a heart rate, heart rate variability, and/or a breathing rate.
Facense Ltd.

Heartbeat monitoring of virtual machines for initiating failover operations in a data storage management system, using ping monitoring of target virtual machines

An illustrative “vm heartbeat monitoring network” of heartbeat monitor nodes monitors target vms in a data storage management system. Accordingly, target vms are distributed and re-distributed among illustrative worker monitor nodes according to preferences in an illustrative vm distribution logic.
Commvault Systems, Inc.

Implementing automatic switchover

One or more techniques and/or computing devices are provided for automatic switchover implementation. For example, a first storage controller, of a first storage cluster, may have a disaster recovery relationship with a second storage controller of a second storage cluster.
Netapp Inc.

Heartbeat monitoring of virtual machines for initiating failover operations in a data storage management system, including operations by a master monitor node

An illustrative “vm heartbeat monitoring network” of heartbeat monitor nodes monitors target vms in a data storage management system. Accordingly, target vms are distributed and re-distributed among illustrative worker monitor nodes according to preferences in an illustrative vm distribution logic.
Commvault Systems, Inc.

Heartbeat monitoring of virtual machines for initiating failover operations in a data storage management system, including virtual machine distribution logic

An illustrative “vm heartbeat monitoring network” of heartbeat monitor nodes monitors target vms in a data storage management system. Accordingly, target vms are distributed and re-distributed among illustrative worker monitor nodes according to preferences in an illustrative vm distribution logic.
Commvault Systems, Inc.

Dynamic and adaptive approach for failure detection of node in a cluster

The present disclosure discloses a method and a network device for failure detection of nodes in a cluster. Specifically, a network device transmits data to another device at a first time.
Aruba Networks, Inc.

Inhibitors of myh7b and uses thereof

The present invention provides nucleic acid inhibitors of myh7b and compositions thereof. The present invention also provides methods of treating or preventing a cardiac disorder such as cardiac hypertrophy, myocardial infarction, or heart failure in a subject by administering to the subject an inhibitor of myh7b.
Miragen Therapeutics, Inc.

Cartridge and increasing myocardial function

The present invention relates to a cytopheretic cartridge for use in treating and/or preventing inflammatory conditions that affect myocardial function and to related methods. The cartridge can be used in treating a subject with myocardial dysfunction, such as a subject with chronic heart failure and/or acute decompensated heart failure..
Cytopherx, Inc.

Anatomic fit of a percutaneous vad for right heart support

An apparatus is disclosed including: a cannula having a shape closely matched to the anatomy of the right ventricle of the human heart, where the cannula has an outflow port configured to be located proximal the pulmonary artery and an inflow port located proximal the inferior vena cava. In some embodiments, the cannula is a close fit to the anatomy of at least 90%, 95%, or more of the population..
Abiomed, Inc.

Ldl quantitation and methods of use

The present invention features, in certain aspects, methods of promoting endocytosis of ldl with α1pi or peptides derived from α1pi. The present invention also provides methods for decreasing ldl levels in response to α1pi augmentation therapy.

Enzyme-responsive nanoparticles

Described herein, inter alia, are compositions and methods for using block copolymers and polymeric micelles for treating myocardial infarction, cardiomyopathy, or heart failure in a subject in need thereof.. .
The Regents Of The University Of California

Systems and methods for delivering and deploying an artificial heart valve within the mitral annulus

The present disclosure describes devices, systems, and methods for loading, delivering, positioning, and deploying an artificial heart valve device at the mitral annulus. A delivery system includes a delivery member coupled to a handle assembly and extending distally from the handle assembly.

Expandable valve prosthesis with sealing mechanism

A prosthetic heart valve includes at least one sealing member. The sealing member is adapted to conform to any surface irregularities found on the inner surface of the valve annulus, including any calcium deposits formed on the valve leaflets.
Mayo Foundation For Medical Education And Research

Prosthetic heart valve with cusp positioners

A prosthetic heart valve has three cusp regions positioned at an inflow end intermediate three commissure regions positioned at an outflow end thereof. A support frame including three cusp positioners is fixed with respect to a leaflet frame and located intermediate each pair of adjacent commissure regions.
Edwards Lifesciences Corporation

Vascular filter

An inferior vena cava filter (340) for use in the inferior vena cava (4) to capture thrombus (8) passing through the inferior vena cava (4) towards the heart and lungs to prevent pulmonary embolism comprises a proximal support hoop (302), a distal support hoop (312) and a plurality of support struts (303) extending between the proximal support hoop (302) and the distal support hoop (312). The filter (340) also comprises a plurality of capture arms (121) which are movable from a capturing configuration to an open configuration.
Novate Medical Limited

Reconstruction of flow data

Described herein are technologies for facilitating reconstruction of flow data. In accordance with one aspect, the framework receives a four-dimensional projection image dataset and registers one or more pairs of temporally adjacent projection images in the image dataset.
Siemens Healthcare Gmbh

Heart sound processing detecting cardiopathy

A heart sound processing method for detecting cardiopathy includes: partitioning heart sound data to obtain a plurality of heart sound data fragments; converting the heart sound data fragments with continuous wavelet transformation to obtain cwt (continuous wavelet transformation) data; converting the heart sound data fragments with short-time fourier transformation to obtain stft (short-time fourier transformation) data; and comparing the cwt data and the stft data with at least one ultrasound data sample of cardiopathy to seek at least one correlation between time and frequency for identifying cardiopathy.. .
National Kaohsiung University Of Applied Sciences

Heart rate detection architecture

There is provided a system architecture including a ppg hardware module and a mems hardware module. The ppg hardware module processes ppg raw data, which is generally composed of analog signals or digital signals.
Pixart Imaging Inc.

Method and monitoring heartbeats

A ballistocardiographic method and monitoring system calculates an indicator of the average heart rate of a test subject within a time interval. The test subject may be a fetus inside a mother's belly, or infant lying in the same bed as an adult.
Murata Manufacturing Co., Ltd.

Wearable and unobtrusive multi-sensor array and pulse wave velocity imaging

Novel and advantageous systems, devices, and methods for pulse wave velocity (pwv) imaging that enable precise central blood pressure (bp) estimation are provided. A multi-sensor array can provide two-dimensional pwv, thereby achieving the pwv imaging and precise central bp estimation.
The Chinese University Of Hong Kong

Biological signal processing device and blood pressure measurement system

An r-wave of a heartbeat signal accompanied by periodic fluctuation is detected to obtain the average value of an rr interval. Further, a waveform of a heart sound signal, which periodically fluctuates in synchronization with the heartbeat signal, is forcibly repositioned at an interval equivalent to the average value of the rr interval.
Ai Technology Inc.

Methods, systems and devices for measuring heart rate

A system and method of tracking activity includes a motion sensor, a light source and a light detector. The light detector is configured to capture an amount of the light that is reflected back to the light detector, at least a first portion of the light reflected back to the light detector is reflected from a blood vessel disposed under a skin adjacent to the housing.
Fitbit, Inc.

Blood pressure and cardiac monitoring system and method thereof

A blood pressure and cardiac monitoring system includes a sensing assembly, a processor, a memory, a communication interface, and any suitable computer implemented modules communicatively coupled to each other via a bus. The sensing assembly comprises of a first sensor (single or multi-axes) located at a first axis of a target generating a first time-dependent motion waveform representative of one or more contractile properties of the target's heart and a second sensor (single or multi-axes) located at a second axis of the target generating a second time dependent motion waveform representative of the target's blood flow.
Robert Bosch Gmbh

Analytic identity measures for physical access control methods

A personal electronic device enables access to and occupancy of a secure space by providing measures of behaviors, personal attributes, history of transactions and movements that are used to validate continuous authentication and authorization of the device's possessor. This addresses the vulnerability of a misplaced, lost, or stolen electronic credential.

Signal continuity assessment using embedded watermarks

Methods, apparatus, and systems use embedded watermarks to determine whether the segments of a multimedia content has been rearranged. The embedded watermarks are recovered from the content and one or more attributes associated with the recovered watermarks are identified.
Verance Corporation

Heartbeats and consensus in verifiable outsourced ledgers

Heartbeat consensus forming for the state of a digital ledger built upon a blockchain to provide users with the ability to securely, accurately, and verifiably share state information between distrustful parties is provided herein. The digital ledger is hosted in a networked environment, accessible by multiple parties.
Microsoft Technology Licensing, Llc.

Platform communication protocol

A host chipset heartbeat may be utilized, in some embodiments, to handle interrupts from external devices on a power efficient basis. The availability of the host chipset heartbeat may be signaled to external devices and those external devices may time their activities to a period of time when not only are resources available, but the assertion of the activity is advantageous because the host chipset is already transitioning from a lower power consumption state..
Intel Corporation

Crystalline form of ahu377, preparation method and use thereof

The present disclosure relates to a novel crystalline form of a compound of formula (i), preparation method and use thereof. The novel crystalline form in the present disclosure has good stability, low hygroscopicity, and remarkable purification effect in process.
Crystal Pharmatech Co., Ltd

Athletic tracking device

An activity tracking device having at least two different models. One model would be a fitness smart watch version, with or without extra sliders, buttons or watch facing touch screen selection for tracking water and fruit/vegetable intakes, and with the typical smart watch features, including a pedometer, heart-rate monitor, altimeter, stop watch, vibrating notifications, alerts, etc.

Atrial tracking in an intracardiac ventricular pacemaker

An intracardiac ventricular pacemaker is configured to detect a ventricular diastolic event from a motion signal received by a pacemaker control circuit from a motion sensor. The control circuit starts an atrial refractory period having an expiration time set based on a time of the detection of the ventricular diastolic event.
Medtronic, Inc.

Enabling and disabling anti-tachyarrhythmia pacing in a concomitant medical device system

An implantable medical device comprising a signal generator configured to generate and deliver anti-tachyarrhythmia pacing (atp) to a heart of a patient and processing circuitry. The processing circuitry is configured to detect an enable event, responsive to detecting the enable event, enable the delivery of atp by the signal generator, detect a disable event indicating that another implantable medical device cannot be relied upon to deliver an anti-tachyarrhythmia shock, and responsive to detecting the disable event, disable delivery of atp..
Medtronic, Inc.

Heart pump driveline power modulation

Systems and method for powering an implanted blood pump are disclosed herein. The system can be a mechanical circulatory support system.
Tc1 Llc

Method for suppressing increase in heart rate during exercise, and composition for suppressing increase in heart rate

There is provided a method comprising orally administering a composition before and/or during exercise. The composition contains a casein hydrolysate containing a free amino acid and a peptide, or a mixture of the free amino acid and the peptide.
Asahi Calpis Wellness Co., Ltd.

Compositions and methods for cognitive health and memory

The present disclosure is a compound, a method of making the compound and method of using such compound preferably in the form of a dietary supplement that, when administered, is capable of treating heart disease and heart-related disorders, among other symptoms. The unique combination of the composition is preferably administered orally.
Script Essentials, Llc

Transapical mitral valve replacement

A prosthetic heart valve includes a collapsible and expandable stent having an outflow end and an inflow end, a plurality of commissure features attached to the stent, a plurality of anchoring features disposed on legs of the stent, the plurality of anchoring features being coupleable to a delivery device for repositioning, and a valve assembly disposed within the stent. The anchoring features may be configured to attach to heart tissue to help secure the prosthetic heart valve in an operating position..
St. Jude Medical, Cardiology Division, Inc.

Valve replacement using rotational anchors

Features for a heart valve device are described. The device may include a frame with anchors configured to secure the device to tissue.
Millipede, Inc.

Prosthetic valve and deployment system

A prosthetic heart valve, for example a tricuspid valve, may include a flexible membrane and a frame. The frame may be attached to the periphery of the tricuspid orifice.
Trisol Medical Ltd.

Buckle pad

A replacement heart valve implant may include an expandable anchor member actuatable between a delivery configuration and a deployed configuration, a plurality of locking mechanisms configured to maintain the expandable anchor member in the deployed configuration, one or more valve leaflets attached to each of the plurality of locking mechanisms, and at least one polymeric laminate corresponding to each locking mechanism, each of the at least one polymeric laminate sized and configured for mounting between a first portion of the corresponding locking mechanism and the expandable anchor member.. .
Boston Scientific Scimed, Inc.

Devices and methods for left atrial appendage closure

Closure devices and methods for ligating tissue, such as the left atrial appendage, generally, include an elongate body having a first lumen therethrough, a snare loop assembly, a vacuum tube, and an imaging device. The snare loop assembly may include a snare and a suture loop releasably coupled to the snare and may at least partially extend from a distal end of the elongate body.
Sentreheart, Inc.

Method and device for processing bio-signals

A method for computing the heart rate value of an user, including detecting a time-dependent optical waveform including a pulse induced by the heartbeat with an optical pulse sensor attached to the user, detecting of a time-dependent accelerometer waveform by an inertial sensor arranged in proximity of the optical pulse sensor, computing of frequency components of the time-dependent optical waveform by a mathematical transform, computing of frequency components of the time-dependent accelerometer waveform by the mathematical transform, first removing of computed frequency components of the time-dependent accelerometer waveform that are below a pre-defined threshold, second removing the computed frequency components of the time-dependent optical waveform that are matching the computed frequency components, third removing the computed frequency components after the second removing that are below a pre-defined threshold, and choosing one of the computed frequency components from the third removing as the heart rate.. .
Smartcardia Sa

System and cardiac monitoring using adaptive sensitivity/specificity levels

Embodiments of the present disclosure describe methods of adaptive arrhythmia detection comprising monitoring ecg signals of a patient via a patient medical device, detecting and capturing ecg segments based on a heart rate threshold and an initial sensitivity level associated with the heart rate threshold; and adjusting the sensitivity level based on previously captured ecg segments. Embodiments of the present disclosure further describe patient medical devices comprising one or more electrodes and sensing circuitry for monitoring ecg signals of a patient; and a processing module configured to receive the monitored ecg signal, wherein the processing module detects and captures ecg segments based on a plurality of heart rate thresholds and one or more sensitivity levels associated with each of the heart rate thresholds, and adjusts at least one of the one or more sensitivity levels associated with each of the heart rate thresholds..
Medtronic Monitoring, Inc.

System and cardiac monitoring using rate-based sensitivity levels

A system and method for detecting arrhythmic electrocardiogram (ecg) signals includes defining a plurality of threshold heart rates and rate-dependent sensitivity levels for detecting arrhythmic ecg episodes, wherein more clinically relevant heart rates are assigned rate-dependent sensitivity levels with higher sensitivities. Ecg signals are monitored by a medical device, and monitored ecg signals are processed using the plurality of threshold heart rates and rate-dependent sensitivity levels to detect and capture arrhythmic ecg segments..
Medtronic Monitoring, Inc.

Apparatus and ecg-like waveform

A medical apparatus configured to generate, without multiple electrodes, a signal corresponding to electrical impulses of a heart, and to display a waveform of that signal, comprising: a pulse unit comprising sensor(s) for receiving a single channel pulse signal waveform from a live tissue and for generating a digital pulse signal; a memory buffer; one or more processors configured to constantly apply a derivative function to the digital pulse signal and initiate a display signal to display a waveform of the derivative function during a period of time, wherein the waveform of the derivative function has a shape of an ecg signal waveform of the subject taken during the period of time, wherein the derivative function includes Δp(t)/Δt, wherein p represents the pulse signal waveform and t is a time variable; and a digital display or printer device configured to display or print the waveform. Multiple channel embodiment also included..
Cnoga Medical Ltd.

Apparatus and determining bio-information of target using impulse radar

An apparatus and method for determining bio-information of a target using an impulse radar are provided. The method may include generating a frame set by accumulating frames received at preset time intervals, determining a first magnitude spectrum of the frame set corresponding to a first frequency axis by performing a frequency conversion of frames included in the frame set in a sampler index axis direction, determining a second magnitude spectrum of the frame set corresponding to the first frequency axis and a second frequency axis by performing a frequency conversion of the first magnitude spectrum in a time axis direction, determining a third magnitude spectrum of the frame set by adding up values of the second magnitude spectrum for each second frequency, and determining a frequency indicating a peak in the third magnitude spectrum as a heartbeat frequency of the target..
Daegu Gyeongbuk Institute Of Science And Technology

System and physiological parameter monitoring

A device (110), method and system (100) for calculating, estimating, or monitoring the blood pressure of a subject are disclosed. A first signal representing heart activity of a subject may be received.
Vita-course Technologies Co., Ltd.

System and blood pressure monitoring

A device (110), method and system (100) for calculating, estimating, or monitoring the blood pressure of a subject. At least one processor, when executing instructions, may perform one or more of the following operations.
Vita-course Technologies Co., Ltd.

Method and system for detecting user heart rate using live camera feed

A system and method for detecting a heart rate of a user using a portable electronic device is provided. The system includes a first camera mounted to the portable electronic device for taking a series of photographs of the user, a memory for storing the series of photographs including the rgb tone colour details of each pixel for each photograph, and a processor for removing the red and blue tones from each image and for measuring the variation in green tone between each image thereby detecting the heart rate of the user..
Ocr Labs Pty Ltd

Magnetic resonance imaging apparatus and magnetic resonance imaging method

A magnetic resonance imaging apparatus according to an embodiment includes processing circuitry and sequence control circuitry. The processing circuitry sets a pattern based on information on heartbeats or pulsebeats of a subject, the pattern being an imaging condition of a pulse sequence for collecting data at a plurality of timings along a relaxation curve of longitudinal magnetization in synchronization with heartbeats or pulsebeats and the pattern defining a relation between heartbeats or pulsebeats, an inversion pulse, and a data collection timing.
Toshiba Medical Systems Corporation

Instrumented toilet seat

A toilet seat with handles is disclosed. The handles include light transmitters and light receivers.

Animal models for cardiomyopathy

Genomically modified livestock animals having a modification in one or more genes implicated in heart failure are provided. The animals provide models for various pathologies in heart failure including dilated cardiomyopathy and hypertrophic cardiomyopathy and can be used for investigation of new treatment methods including interventional devices, biologics and pharmaceuticals.
Recombinetics, Inc.

Internet-of-things-based safety system

Building safety system architecture, methods, and mediums. A method includes receiving substantially-continuous heartbeat communications from a plurality of safety control devices over a packet data network.
Siemens Industry, Inc.

Device for providing health information and advice to shoppers

A product assistant device may attach to a shopping cart or other baggage cart and provide information and guidance on products within a retail space. The assistant device may provide physiological information from sensors such as heart rate, blood pressure, or other non-invasively measured characteristics via a display.
Ach Food Companies, Inc.

Methods for detecting an increased risk for coronary heart disease

The invention relates generally to an allele on human chromosome 9 associated with increased risk for coronary heart disease and the use or detection of such an allele in determining whether a human has an increased risk for coronary heart disease. In one aspect, the invention relates to methods for detecting a predisposition or propensity or susceptibility for coronary heart disease in a human, comprising detecting the presence of an allele on human chromosome 9 that is associated with an increased risk for coronary heart disease in a human.
Board Of Regents, The University Of Texas System

Treadmill and monitoring system

A monitoring and computing system for use with a treadmill, includes an intelligent sensing and computing system includes the data collection box and the sensors. The sensors includes the infrared sensor for sensing the speed, the six axes sensor for sensing the slope and the step frequency, the electrocardiogram sensor for sensing the heartbeat.
Foxconn Interconnect Technology Limited

Method and pain management using heart sounds

An example of a pain management system may include a heart sound sensor, a heart sound sensing circuit, a heart sound detector, a parameter generator, and a pain analyzer. The heart sound sensor may be configured to sense a heart sound signal.
Boston Scientific Neuromodulation Corporation

Sleep system

A sleep assistance device is provided-for, including a housing, a contactless biometric sensor, a processor, memory, and a speaker. The processor may detect a user's sleep state by reading signals from the contactless biometric sensor based on at least one of a detected change in heartrate, body movement, or respiration.
Bose Corporation

Cannula system with sterile connector, blood pump, and patient harness

A system for assisting a patient's heart has a pump, an oxygenator, a holder having a pump receiving portion for removably receiving the pump and an oxygenator receiving portion for removably receiving the oxygenator, and a harness configured to surround at least a portion of a patient's torso. The holder is connected to the harness.
Cardiac Assist, Inc.

Lisinopril formulations

Provided herein are stable lisinopril oral liquid formulations. Also provided herein are methods of using lisinopril oral liquid formulations for the treatment of certain diseases including hypertension, heart failure and acute myocardial infarction..
Silvergate Pharmaceuticals, Inc.

Dietary supplements containing dehydrated strawberry

Compositions and processes are disclosed for a capsule, tablet, or pill comprised of powdered strawberries. Fresh strawberries are washed, de-calyxed, and then processed into a dry pulp.

Prosthetic device for heart valve reinforcement and remodeling procedures

A prosthetic heart valve reinforcement ring is disclosed for reinforcing a natural heart valve with leaflets. The prosthetic ring includes a ring body sized and dimensioned to fit around the annulus of the heart valve.

Apical control of transvascular delivery of prosthetic mitral valve

Apparatus and methods are described herein for use in the delivery and deployment of a prosthetic mitral valve. In some embodiments, after a prosthetic valve has been at least partially delivered from a delivery sheath into the left atrium of a heart, a valve positioning device can be used to engage with and position the prosthetic valve within the mitral annulus.
Tendyne Holdings, Inc.

Devices and methods for transcatheter heart valve delivery

A delivery device for a collapsible prosthetic heart valve includes an operating handle and a catheter assembly. The operating handle may include a housing defining a movement space therein, a carriage assembly moveable in a longitudinal direction within the movement space, a deployment actuator coupled to the housing and rotatable relative to the housing, and a coupling assembly rotationally fixed to the deployment actuator.
St. Jude Medical, Cardiology Division, Inc.

Tethers for prosthetic mitral valve

This invention relates to the design and function of a single-tether compressible valve replacement prosthesis which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed combats the process of wear on anchoring tethers over time by using a plurality of stent-attached, centering tethers, which are themselves attached to a single anchoring tether, which extends through the ventricle and is anchored to a securing device located on the epicardium..
Tendyne Holdings, Inc.

Prosthetic heart valve with reduced stitching

An implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration includes an annular frame including a plurality of angled strut members, and a skirt member secured to the frame. The skirt member includes a plurality of extension portions wrapped around at least one strut member adjacent the extension portions.
Edwards Lifesciences Corporation

Prosthetic heart valve

A prosthetic heart valve includes a valve frame (2), on which a plurality of valve leaflets (8) are fixed, and a fastening area for fastening in a blood vessel, which axially adjoins the valve frame (2). A stabilizing ring (14) is arranged in the fastening area.

Valved stent for mitral and tricuspid heart valve replacement

An implantable valved stent for a patient's heart is formed by a stent supporting a cloth structure. The valved stent includes an upper mounting portion and a lower valved portion.
Peijia Medical Co., Ltd.

Heart valve prosthesis

A heart valve prosthesis includes a downstream first axial end (6) and an upstream second axial end (8) and a stitching ring (10) extending in an arcuate manner for stitching in a blood vessel. The arcuate course of the stitching ring (10) is formed by three arcs (12) and three transition regions (14).

Device and improving heart valve function

The invention is a method for reducing regurgitation through a mitral valve. The device and method is directed to an anchor portion for engagement with the heart wall and an expandable valve portion configured for deployment between the mitral valve leaflets.
Edwards Lifesciences Ag

Assistive device for a cardiac valve

A device for reducing heart valve regurgitation including a plug for placing between natural heart valve leaflets, the plug shaped so that, upon systole, the natural heart leaflets coapt upon the plug, a frame attached to the plug by a bridging element, for supporting the plug between the natural heart valve leaflets, the frame having at least one dimension in a plane of the heart valve annulus which is wider than the diameter of the heart valve annulus, and a plurality of anchors attached to the device, for preventing the device from being swept upstream of the heart valve annulus upon systole. Related apparatus and methods are also described..
Mitrassist Medical Ltd.

Systems and methods for patient-specific modeling of the heart for prediction of targets for catheter ablation of ventricular tachycardia in patients with implantable cardioverter defibrillators

A system, computer-readable medium and method can include receiving three-dimensional imaging data of a subject's heart, the subject having an icd, wherein the icd causes an imaging artifact in the three-dimensional imaging data that includes regions that are free of the artifact and regions that are affected by the artifact; segmenting the regions that are free of the artifact into a plurality of normal tissue regions and remodeled tissue regions for the subject; extrapolating from the regions that are free of the artifact to provide extrapolated three-dimensional imaging data corresponding to the regions that are affected by the artifact; and simulating at least one of electrophysiological or electromechanical activity of the subject's heart using the segmented and extrapolated three-dimensional imaging data, the simulating including providing a preselected alteration of electrophysiological or electromechanical behavior of the subject's heart for a target of said subject-specific cardiac ablation procedure.. .
The Johns Hopkins University

Vital signs monitoring system

A vital signs monitoring system comprises a processing unit (300) for estimating an activity energy expenditure (aee), a first activity energy expenditure determining unit (320) for determining a first activity energy expenditure (aeehr) based on heart rate data (hr), a second activity energy expenditure determining unit (330) for determining a second activity energy expenditure (aeeac) based on motion data (ac), and a weighting unit (340) for determining a first and second weighting factor (whr, wac) based on a first and second probability relating to a high exertion (hh) and relating to a low exertion (hl), and activity energy expenditure calculating unit (350) for computing an overall activity energy expenditure (aeeo) based on the first activity energy expenditure (aeehr) weighted by the first weighting factor (whr) and on the second activity energy expenditure (aeeac) weighted by the second weighting factor (wac).. .
Koninklijke Philips N.v.

Sleep assessment using a home sleep system

A sleep assessment device is provided for, including biometric sensors for detecting a heart rate, respiration, or movement of a user. The device detect a user's sleep state by reading signals from the biometric sensor and logs detected information in a sleep record.
Bose Corporation

Sleep quality scoring and improvement

A sleep scoring device is provided for, including a contactless biometric sensor, a processor, memory, and a microphone. The sleep scoring device may detect a user's sleep state by reading signals from the contactless biometric sensor based on at least one of a detected change in heartrate, body movement, or respiration, and log the biometric information.
Bose Corporation

Systems and methods for facilitating exercise monitoring with real-time heart rate monitoring and motion analysis

Systems and methods for facilitating exercise monitoring are provided. A representative method includes: using a processor, having processor circuitry, to: obtain motion readings reported from an inertial sensor of a wearable device and corresponding to a scheduled training types; receive the schedule and a target status of a target training count or a target training time corresponding to each of the training types; determine the current training type based on the schedule; select one of the computing models based on the current training type; compare the set of matching characteristics corresponding to the current training type and the motion readings until the target status has been attained for the current training type; select a next training type based on the schedule; select another one of the computing models based on the next training type; determine activity information associated with the schedule; and compute an exercise amount of the user based on the target status, the activity information, and the schedule..
Cm Hk Limited

Stress detection method and apparatus

Embodiments of the present disclosure provide techniques and configurations for an apparatus for stress event detection. In some embodiments, the apparatus may be a wearable device and may include at least one first sensor disposed on the wearable apparatus to generate a first sensor signal indicative of a brain activity of a user, at least one second sensor disposed on the wearable apparatus to generate a second sensor signal indicative of a heart rate of the user, and at least one third sensor disposed on the wearable apparatus to generate a third sensor signal indicative of a respiration rate of the user.
Intel Corporation

Echolocation locating a catheter tip

A system for locating the tip of a catheter inside a human body is provided. The system includes a housing; a sound emitter and a sound sensor housed in the housing; a waveform generator configured to generate a fixed waveform at a desired frequency and having desired characteristics and output the fixed waveform to the sound emitter; a peripherally inserted central catheter fluidly coupled to the housing and configured to propagate the fixed waveform toward a heart of a patient; a sound sensor housed within said housing, said sound configured to sense sound waves reflected from the heart as the peripherally inserted central catheter is progressed toward a heart of a patient; and a waveform analyzer operably coupled to the output of the waveform generator and input from the sound sensor, the waveform analyzer operable to determine the difference between the output and input..
Medical Components, Inc.

Method and monitoring an organ of a patient

An apparatus for determining tissue versus fluid components of an organ include a detector that generates a detector signal based on electrical signals derived from tissue and fluid. The apparatus includes a signal processor in communication with the detector which subtracts in real time a tissue component from the detector signal and produces a fluid volume signal.
Board Of Regents, The University Of Texas System

Apparatus and feature extraction and classification of fetal heart rate

Provided are a device and method for receiving a fetal heart rate (fhr) signal at each interval during a monitoring period, receiving a uterine pressure (up) signal at each of the intervals to obtain a plurality of fhr-up signal pairs, and extracting a feature value for each fhr-up signal pair, with the feature value being extracted from a predefined alphabet of feature values.. .
The Research Foundation For The State University Of New York.

Cardiovascular assist system that quantifies heart function and faciltates heart recovery

The systems, devices, and methods presented herein use a heart pump to obtain measurements of cardiovascular function. The heart pumps described herein can operate in parallel with and unload the heart.
Massachusetts Institute Of Technology

Blood pressure calculation method based on pulse return wave transmission time, and blood pressure monitor

A method for calculating blood pressure based on pulse return wave transmission time, and a blood pressure monitor have been provided. The method includes the following steps: s1: collecting and storing pulse waveform data at a fingertip; s2: processing said pulse waveform data to obtain a heart rate and parameters of a plurality of pulse periods, detecting time axis coordinates of a primary wave starting point spl1 of a pulse wave and a growth point spl2 of a return wave in each of said pulse periods, and calculating a corresponding pulse return wave transmission time rwtt: rwtt=spl2−spl1; s3: calculating the pulse return wave transmission time rwtt in each of said pulse periods to form a rwtt array; and s4: calculating systolic and diastolic pressures based on said rwtt array and the heart rate..
Hangzhou Nanochap Electronics Co., Ltd.

Method and system for visualization of heart tissue at risk

Exemplified methods and systems facilitate presentation of data derived from measurements of the heart in a non-invasive procedure (e.g., via phase space tomography analysis). In particular, the exemplified methods and systems facilitate presentation of such measurements in a graphical user interface, or “gui” (e.g., associated with a healthcare provider web portal to be used by physicians, researchers, or patients, and etc.) and/or in a report for diagnosis of heart pathologies and disease.
Analytics For Life

Lactuca sativa cultivar cvx-35

According to the invention, there is provided a novel romaine lettuce cultivar, designated cvx-35. ‘cvx-35’ is described as a vigorous romaine cultivar recommended for the main lettuce growing regions of california and arizona.
Central Valley Seeds, Inc.

Peperomia plant named 'piccolo banda'

A new cultivar of peperomia plant named ‘piccolo banda’ that is characterized by small heart shaped leaves and light green leaves with brown veins on the upper surface.. .
Eternal Plant Boijl B.v.

Systems, methods, and devices having stretchable integrated circuitry for sensing and delivering therapy

System, devices and methods are presented that integrate stretchable or flexible circuitry, including arrays of active devices for enhanced sensing, diagnostic, and therapeutic capabilities. The invention enables conformal sensing contact with tissues of interest, such as the inner wall of a lumen, a the brain, or the surface of the heart.
Mc10, Inc.

Biofeedback virtual reality system and method

The present disclosure relates to optimizing an individual's heart-rate cycle using a biofeedback virtual reality system so as to facilitate coherence and resonance, by which a subject's emotional state, stress levels and performance may be concurrently improved. In an embodiment, a biofeedback virtual reality system and method as disclosed herein accesses an individual's current coherence state and based upon that analysis, provides a virtual environment related to the individual's current coherence state and allows the individual to progress to alternative virtual environments that represent “better” or more coherent states.
Merlin Digital General Trading Llc

Processing timestamps and heartbeat events for automatic time progression

An event processing system for processing events in an event stream is disclosed. The system is configured for configuring a stream processor to micro-batch incoming events from a stream source.
Oracle International Corporation

Wireless midfield systems and methods

Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters.
The Board Of Trustees Of The Leland Stanford Junior University

Leadless cardiac stimulation systems

Various configurations of systems that employ leadless electrodes to provide pacing therapy are provided. In one example, a system that provides multiple sites for pacing of myocardium of a heart includes wireless pacing electrodes that are implantable at sites proximate the myocardium using a percutaneous, transluminal, catheter delivery system.
Cardiac Pacemakers, Inc.

Compositions and methods for cardiac therapy

Provided herein are methods and compositions for cardiac therapy. Such compositions include extracellular-matrix (ecm)-based products that can be used to support tissue repair.
The Regents Of The University Of California

Methods and compositions for enhancing cardiac contractility for treatment of heart failure

The invention provides a therapeutically-effective method for treatment of heart failure (hf), chronic heart failure, and heart failure post myocardial infarction (mi). This method treats heart failure by enhancing cardiac contractility in a patient by activating β-arrestin 2 to enhance sarco(endo) plasmic reticulum ca−2 atpase (serca-2a) small ubiquitin-like modifier-ylation (sumolation).
Nova Southeastern University

Herbal supplement ''optimal cholesterol''

“optimal cholesterol” utilizes edible nature plant extracted by a variety of technology, it is one of the nature plant medicines which can treat atherosclerotic coronary heart disease, cerebral vascular disease and systemic vascular disease in the world. Its function is to soften the arterial blood vessels, and to treat arteriosclerosis, protect and repair the vascular endothelial cells; soft plaque, fibrous plaque and calcified plaque are removed during the process of preventing plaque rupture, bleeding, erosion and ulcer; regulate micro-circulation, enhance the ability of coronary artery blood supply, adjust heart rate, furthermore, there's none toxic side effects after long-term use..

Methods and materials for treating calcific aortic valve stenosis

This document provides methods and materials involved in treating cardiovascular conditions such as calcific aortic valve stenosis. For example, methods and materials for using sgc agonists or a combination of sgc agonists and pde5a inhibitors to reduce calcification of heart valves and/or vessels or to slow progression of aortic sclerosis to calcific aortic valve stenosis are provided..
Mayo Foundation For Medical Education And Research

Methods and compositions for treating degenerative and ischemic disorders

Model systems have shown that shifting a cell's reliance from oxidative phosphorylation (oxphos) to glycolysis can protect against cell death. Exploiting the therapeutic potential of this strategy, however, has been limited by the lack of clinically safe agents that remodel energy metabolism.
The General Hospital Corporation

Steerable lesion excluding heart implants for congestive heart failure

Devices, systems, and methods for treating a heart of a patient may make use of one or more implant structures which limit a size of a chamber of the heart, such as by deploying a tensile member to bring a wall of the heart toward (optionally into contact with) a septum of the heart.. .
Bioventrix, Inc.

Apparatuses and methods for at least partially supporting a valve leaflet of a regurgitant heart valve

An apparatus for partially supporting a leaflet of a regurgitant heart valve comprises at least one subvalvular device including a subvalvular supporting portion including a leaflet-contacting upper supporter surface longitudinally spaced from an oppositely facing lower supporter surface. A supporter perimeter wall extends longitudinally between the upper and lower supporter surfaces, with at least a portion contacting a subvalvular cardiac wall adjacent to the heart valve.

Assembly for replacing a heart valve or coronary angioplasty assembly including a delivery catheter with or without introducer

The present invention relates to an assembly for replacing a heart valve or coronary angioplasty assembly, including an insertion sheath (13) of an introducer (1) or a delivery catheter (1′), which is smaller in size than an introducer, intended for being inserted into an artery of a human body. The invention essentially involves integrating the metal substrate of an electrode of the cardiac stimulator directly into the sheath for insertion into the artery of a patient..

Stent cell bridge for cuff attachment

A prosthetic heart valve includes a collapsible stent extending from an inflow end to an outflow end, and a cuff having an inflow end an outflow end. The stent includes first and second circumferential rows of cells defined by first and second pluralities of struts, respectively.
St. Jude Medical, Cardiology Division, Inc.

Prosthetic heart valve with paravalvular leak mitigation features

A prosthetic heart valve includes a collapsible and expandable stent with a valve assembly disposed therein. A first cuff is positioned on the lumenal or ablumenal surface of the stent.
St. Jude Medical, Cardiology Division, Inc.

Multiple aperture sling for mitral heart valves

A sling with multiple openings may be installed in a mitral valve annulus. Within each opening, individual valves may be placed.
Infinity Patent Holdco Llc

Heart valve pinch devices and delivery systems

Pinch devices and access systems that can be used to secure a prosthetic heart valve to a heart valve annulus and to treat valvular insufficiency. A pinch device can be a separate expandable element from the prosthetic heart valve that is first advanced to the annulus and deployed, after which an expandable prosthetic heart valve can be advanced to within the annulus and deployed.
Edwards Lifesciences Corporaton

Device and mitral valve regurgitation treatment

A mitral valve replacement device is adapted to be deployed at a mitral valve position in a human heart. The device has an atrial flange defining an atrial end of the device, a ventricular portion defining a ventricular end of the device, the ventricular portion having a height ranging between 2 mm to 15 mm, and an annulus support that is positioned between the atrial flange and the ventricular portion.
Sino Medical Sciences Technology, Inc.

Method and system for image processing to determine blood flow

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data.
Heartflow, Inc.

Methods and devices for diastolic assist

The devices and method described herein allow for therapeutic damage to increase volume in these hyperdynamic hearts to allow improved physiology and ventricular filling and to reduce diastolic filling pressure by making the ventricle less stiff. For example, improving a diastolic heart function in a heart by creating at least one incision in cardiac muscle forming an interior heart wall of the interior chamber where the at least one incision extends into one or more layers of the interior heart wall without puncturing through the interior heart wall and the incision is sufficient to reduce a stiffness of the interior chamber to increase volume of the chamber and reduce diastolic filing pressure..

Methods of ablating tissue using a catheter injection system

At the present time, physicians often treat patients with atrial fibrillation (af) using radiofrequency (rf) catheter systems to ablate conducting tissue in the wall of the left atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use.
Ablative Solutions, Inc.

System for repeated delivery of implantable devices

Disclosed herein is a medical tool adapted to engage and disengage with leadless pacemakers to allow for the repeated use of the tool in delivering and implanting multiple leadless pacemakers into a patient heart in a serial or repeated manner. The tool includes a handle, an attachment mechanism, a torque portion, and a rotation limiter.
Pacesetter, Inc.

Blood pressure measuring device and blood pressure measuring method using the same

There is provided a blood pressure measuring device comprising: a first heart rate measuring module configured to measure a first heart rate at a first location of an examinee's body; a second heart rate measuring module configured to measure a second heart rate at a second location of the examinee's body, wherein the first location is different from the second location, wherein a first spacing between the first location and a heart of the examinee is different from a second spacing between the second location and the heart of the examinee; and a blood pressure estimation module configured to estimate a blood pressure of the examinee based on the first and second heart rates measured by the first and second heart rate measuring modules.. .
Gwangju Institute Of Science And Technology

Systems, devices, and methods for performing trans-abdominal fetal oximetry and/or trans-abdominal fetal pulse oximetry using a fetal heartbeat signal

Light reflected from a pregnant woman's abdomen and fetus contained therein that has been received by a detector and converted into a reflected electronic signal may be received by a processor. A portion of the reflected electronic signal that is reflected from the fetus may be isolated and the isolated portion of the reflected electronic signal may be analyzed to determine a fetal hemoglobin oxygen saturation level of the fetus.
Raydiant Oximetry, Inc.

Method and determining cardiac performance in a patient with a conductance catheter

An apparatus for determining cardiac performance in the patient includes a plurality of electrodes adapted to be placed in the patient and in communication with a heart chamber of the patient for measuring conductance and blood volume in the heart chamber of the patient; and a processor for determining instantaneous volume of the ventricle based on measurement of complex admittance at a plurality of frequencies to identify mechanical strength of the chamber, the processor in communication with the electrodes. A method for determining cardiac performance in a patient..
Board Of Regents, The University Of Texas System

Cvhr shape measurement devices

In some embodiments, a device to measure a shape of cyclic variation of heart rate (cvhr) comprises a processor to detect cvhr from time series data of cardiac or pulse wave inter-beat interval, heart rate, or pulse rate; acquire at least one shape property index with respect to a waveform of the detected cvhr; and evaluate health risk based on the at least one shape property index. The cvhr appears periodically in the time series data.
Suzuken Co., Ltd.

System and simulating fetal heart rate for noninvasive intra-partum fetal monitoring

A method and apparatus to simulate a fetal heart rate to train clinicians in using a doppler probe. The apparatus includes an enclosure housing a bladder, with a piece of deformable material to be placed in contact with the bladder and the doppler probe.
Dynasthetics, Llc

Dynamic assignment of media advertising orders to broadcast inventory

A planning system can receive media advertising orders including flexibility attributes indicating whether the orders are flexible with regard to various different circumstances. The planning system can obtain both booked an unbooked inventory from a traffic and billing system, and determine associations or re-associations between the advertising orders and the booked and unbooked inventory based on the flexibility attributes.
Iheartmedia Management Services, Inc.

User identification via motion and heartbeat waveform data

The disclosure relates to methods, devices, and systems to identify a user of a wearable fitness monitor using data obtained using the wearable fitness monitor. Data obtained from motion sensors of the wearable fitness monitor and data obtained from heartbeat waveform sensors of the wearable fitness monitor may be used to identify the user..
Fitbit, Inc.

Compositions and methods for metabolic profiling in subjects with heart failure with preserved ejection fraction

Disclosed herein are compositions and methods for targeted metabolomics profiling to provide absolute quantification of a broad array of metabolic intermediates of fatty acids, amino acids, and carbohydrate metabolism for hfpef. In an aspect, the disclosure relates to a method for assessing risk of death or a major adverse cardiac event (mace) in a subject diagnosed with heart failure with preserved ejection fraction (hfpef).
Duke University

Isolation of pulmonary arterial endothelial cells from patients with pulmonary vascular disease and uses thereof

The present disclosure provides methods of obtaining, recovering and culturing pulmonary arterial endothelial cells from an individual patient subjected to a right heart catheterization in regard to diagnosis of pulmonary hypertension. These isolated pulmonary arterial endothelial cells from an individual patient may be utilized to generate cellular phenotyping profile for the cell population, allowing generation of a personalized pharmacotherapy regime to assist the clinician in treatment and prognosis of the disorder for an individual patient..
Allegheny-singer Research Institute

P63 inactivation for the treatment of heart failure

Embodiments of the disclosure include methods and compositions for in situ cardiac cell regeneration, including transdifferentiation of cardiac cells to cardiomyocytes. In particular embodiments, in situ cardiac cell regeneration encompasses delivery of p63 shrna and one or both of hand2 and myocardin, and in specific embodiments further includes one or more of gata4, mef2c, and tbx5.
Baylor College Of Medicine

Method and device for preparing non-embryonic stem cells

The invention relates to a process for preparing a non-expanded tissue derivative, that is not subjected to cell proliferation in vitro, comprising a vascular-stromal fraction enriched in stem and multipotent elements, such as pericytes and/or mesenchymal stem cells, or for preparing non-embryonic stem cells obtained from a tissue sample or from said derivative, wherein said tissue derivatives or said cells are subjected to vibrations derived from a heart sound such to control the degree of differentiation or possible differentiation of said stem and multipotent elements into several other types of cells that is to optimize their potency. The invention relates also to a device for carrying out said process, to stem cells obtainable by the process as well as a drug for the regeneration of an animal tissue..
Llpogems International S.p.a.

Method and system for providing interactivity based on sensor measurements

There is provided a system for providing interactivity to a guest of an experiential venue, based on sensor measurement of the guest. The system comprises a sensor configured to sense a guest variable of the guest, where the sensor may be a biometric sensor, a facial recognition sensor, a voice stress analysis sensor, a gesture recognition sensor, a motion tracking sensor, or an eye tracking sensor, and may sense heart rate or another guest variable.
Disney Enterprises, Inc.

System and cardiac resynchronization

Various embodiments include methods for conducting cardiac resynchronization therapy and systems implementing the method. Various embodiments may include generating, using a processing unit, a three-dimensional (3d) activation map showing the propagation of electrical signals through a heart of a patient, identifying a stimulation point on the heart for cardiac resynchronization; generating real-time images of the heart, displaying, on a display unit, the stimulation point on the real-time images as a virtual stimulation point, implanting a pacing device into the patient at the identified stimulation point, such that the pace maker is aligned with the virtual stimulation point in the real-time images, and stimulating the heart using the pacing device..
Catheter Precision, Inc.

Bioelectric stimulator

Described is a low voltage, pulsed electrical stimulation device for controlling expression of, for example, follistatin, a muscle formation promotion protein, by tissues. Epicardial stimulation is especially useful for heart treatment.
Cal-x Stars Business Accelerator, Inc.

Transseptal puncture using the same

Devices and methods for performing a transseptal puncture procedure using a device which includes either an untapered or tapered blunt end cannula disposed in an introducer carrying a sharp guidewire disposed longitudinally through the lumen of the blunt cannula, and a blunt end dilator wherein the guidewire is flexible and has an atraumatic shape at its tip. The cannula gives the more flexible introducer a defined shape and steerabilty allowing an ordinarily skilled physician to easily access a selected location on the septal wall of the heart for transseptal puncture and introducer placement thereacross without employing an exposed sharp end needle during the procedure..
Pressure Products Medical Supplies Inc.

Emergency cpr sanitation separation device and use

A rescue device for a heart attack victim and a method of rescuing a heart attack victim is provided. The device includes a first tube that is configured to be inserted into the victim's mouth so as to assist in performing cpr and restoring normal breathing by creating a high-pressure environment within the victim's mouth and thus inflating the victim's lungs.

3d filter for prevention of stroke

The present invention relates to implantable endoluminal prostheses and methods of using such devices in preventing clots migration to avoid ischemic strokes. The implantable endoluminal prosthesis is suitable for deployment from the aortic annulus to the aorta and comprises a self-expandable braided framework able to expand from a radially compressed state in a delivery configuration to a radially expanded state, and a radially collapsible valve body comprising an impermeable material.
Frid Mind Technologies

Method and catheter for creating an interatrial aperture

A catheter device with a cutting structure or means on the distal portion is disclosed, along with a medical procedure for using the device. The catheter is utilized in such a way as to create a permanent interatrial aperture in the heart, including creating a permanent interatrial hole and/or removing tissue..
Intershunt Technologies, Inc.

Occluder for occluding an atrial appendage and production process therefor

An occlusion device and a production process for it are described. The occlusion device consists of a mesh or braiding of at least one wire or thread wherein the occlusion device has been given a suitable design using a reshaping and/or heat-treatment process, is self-expandable, and is configured for secure anchoring in an atrial appendage of the left or right atrium of a heart.
Occlutech Holding Ag

System and treating heart tissue

Some embodiments of a system or method for treating heart tissue can include a control system and catheter device operated in a manner to intermittently occlude a heart vessel for controlled periods of time that provide redistribution of blood flow. In particular embodiments, the system and methods may be configured to monitor at least one input signal detected at a coronary sinus and thereby execute a process for determining a satisfactory time period for the occlusion of the coronary sinus.
Miracor Medical Systems Gmbh

Apparatus and heart valve repair

A device 10 for gathering tissue of a heart valve leaflet 2 may include an outer tube 16 extending in an elongation direction, a capture tool 22 moveable in the outer tube between a contained position and a use position, and a tissue securing component 32 disposed at a distal end 17 of the outer tube and adapted to be applied to tissue 8 captured by the capture tool to hold the captured tissue in a gathered configuration. The capture tool may include a first element 20 and a second element 22 that are moveable relative to one another in the elongation direction.
St. Jude Medical, Llc

Method and treating valvular disease

An apparatus for treating or preventing a valvular disease comprises: a ultrasound probe located externally to a heart of patient, able to produce ultrasound waves focused inside the heart and suitable to generate, at a focal spot, a pressure sufficient to result in cavitation, an imaging device for mapping in real time a treatment region of a cardiac valve of the patient, the treatment region comprising at least one leaflet of the cardiac valve, a controller configured for driving the ultrasound probe to emit a sequence of focused ultrasound waves, the controller being further configured for steering the focused ultrasound waves so as to scan the entire treatment region to soften the tissues of the treatment region. A method for treating or preventing valvular disease, carried out using the apparatus is also provided..
Cardiawave

Imaging systems including multi-tap demodulation pixels for biometric measurements

Imaging systems include multi-tap demodulation pixels for biometric measurements such as heart rate or blood oxygen level. Using multi-tap demodulation pixels can, in some cases, help facilitate the generation of differential signals to remove background noise and achieve a higher dynamic range for the biometric measurements..
Heptagon Micro Optics Pte. Ltd.

Sleep stage estimating apparatus, biological data estimating apparatus, sleep stage estimating method, biological data estimating method, sleep stage estimating program, and biological data estimating program

The estimation of the sleep stage at a time point where data does not exist, is enabled. An acquiring unit configured to acquire biological data indicating a wave of a heartbeat; a parameter estimating unit configured to estimate a parameter by using the biological data, with respect to a mathematical expression defining a medium frequency component of the wave of the heartbeat by using the parameter; and a sleep stage estimating unit configured to estimate a sleep stage from a value of the medium frequency component at any time point, based on the mathematical expression to which the estimated parameter is applied, are included..
The University Of Electro-communications

Sleepiness calculation device

A sleepiness calculation device is provided. In a smartphone, i/f obtains heart rate of the subject measured by a heartbeat sensor and measurement time, determines active state of a subject in the state discriminant section, and send it to a server.
Pioneer Corporation

Methods, systems, and identification, characterization, and treatment of rotors associated with fibrillation

Some embodiments described herein relate to a method that includes defining an electro-anatomical model of a heart. The electro-anatomical model can include conduction patterns for multiple patterns or phases identified by a measurement instrument.
Aftx, Inc.

Wearable cardiac electrophysiology measurement devices, software, systems and methods

Disclosed are wearable devices, such as rings and bracelets, for monitoring and diagnosing cardiovascular conditions of a wearer, along with related systems, algorithms and methods. The disclosed wearable devices can continuously monitor the wearer's cardiovascular status by measuring heart rate, motion, blood oxygenation, and/or other properties of the wearer.
Upmc

System to diagnose and manage orthostatic intolerance

An apparatus includes a posture sensing circuit configured to detect a change in posture of a subject; a cardiac signal sensing circuit configured to generate a sensed cardiac signal, wherein the sensed cardiac signal includes heart rate information of the subject; a physiologic sensing circuit configured to generate a sensed physiologic signal, wherein the physiologic signal includes information related to blood pressure of the subject; a storage buffer; and a control circuit operatively coupled to the posture sensing circuit and the storage buffer. The control circuit is configured to initiate storage of the heart rate information and the information related to blood pressure in response to a detected change in posture of the subject..
Cardiac Pacemakers, Inc.

Devices, systems, and methods for physiology monitoring

Software applications, devices, systems, and methods are provided for monitoring, recording, and tracking cardiac health related metrics using an associated computing device. The software applications may monitor, record, and track physiological data such as cardiac electrical activity, heart rate, and blood pressure.
Alivecor, Inc.

Method, device and system for amending heartbeat type

The present disclosure relates to a method, device and system for amending a heartbeat type. The method includes: displaying an interface for presenting heartbeat waveforms; based on a user interface provided on the interface for presenting the heartbeat waveforms, detecting a currently triggered heartbeat type; and when detecting that at least one electrocardiogram waveform on the interface for presenting the heartbeat waveforms is selected, amending a heartbeat type of the selected at least one electrocardiogram waveform as the currently triggered heartbeat type.
Edan Instruments, Inc.

Micro powered ultra-high resolution electromagnetic sensor with real time analog circuitry based artifact cancellation

An ultra-miniature and micro-powered system, apparatus, and method utilizing electromagnetic imaging via minute eddy currents, analog circuit averaging and artifact cancellation, that attaches to the outside of clothing and measures internal bodily functions including but not limited to heart rate, respiration rate, and wetness of underclothing. .
Xtrava Inc

Anti-histone therapy in acute kidney injury

Acute kidney injury (aki) is often associated with damage to remote organs, such as lungs or heart. Aki induces kidney tubular necrosis as well as netosis, programmed neutrophil death leading to neutrophil extracellular traps (nets).
Immunomedics, Inc.

Seat recliner assembly with hollow cross member

A seat recliner assembly for a vehicle may include first and second recliner hearts, a hand lever, and a cross member. The first recliner heart may be mounted to a bracket.
Fisher & Company, Incorporated

Cardiac resynchronization using fusion promotion for timing management

Methods, systems and devices for providing cardiac resynchronization therapy (crt) to a patient using a leadless cardiac pacemaker and an extracardiac device. The extracardiac device is configured to analyze one or more qrs complexes of the patient's heart, determine whether fusion pacing is taking place, and, if not, to communicate with the leadless cardiac pacemaker to adjust intervals used in the crt in order to generate desirable fusion of the pace and intrinsic signals.
Cardiac Pacemakers, Inc.

Transcatheter guidewire delivery systems, catheter assemblies for guidewire delivery, and methods for percutaneous guidewire delivery across heart valves

Transcatheter guidewire delivery systems, catheter assemblies and associated methods for percutaneous guidewire delivery across heart valves are disclosed herein. A catheter assembly configured in accordance herewith includes an elongated tubular component and an alignment assembly at a distal portion of the tubular component and which is adapted to be located at a target location adjacent a heart valve of a patient.
Medtronic Vascular, Inc.

Transcatheter guidewire delivery systems, catheter assemblies for guidewire delivery, and methods for percutaneous guidewire delivery across heart valves

Transcatheter guidewire delivery systems, catheter assemblies and associated methods for percutaneous guidewire delivery across heart valves are disclosed herein. A catheter assembly configured in accordance herewith includes an elongated tubular component and an alignment assembly at a distal portion of the tubular component and which is adapted to be located at a target location adjacent a heart valve of a patient.
Medtronic Vascular, Inc.

Cardiac pump implantation device and method

A system and method for implanting a ventricular assist device (“vad”) within the heart includes one or more tools, each having a tool body with a passage. Each tool body can be engaged with an anchor ring assembly secured to the heart.
Heartware, Inc.

Blood pump assembly and use thereof

The invention provides a blood pump for use with an intravascular ventricular assist system (ivas), as well as a method for utilizing the blood pump to treat heart failure.. .
Nupulsecv, Inc.

Anti-suction blood pump inlet

A heart pump assembly includes an impeller blade coupled to a rotor or a drive shaft, a cannula, a distal projection coupled to a distal end of the cannula and a blood inlet having a plurality of apertures. The plurality of apertures are radially oriented and disposed about a circumference of the cannula.
Abiomed, Inc.

Treatment of heart disease

Disclosed herein are methods, compositions and kits for treating cardiac stem cells to be administered to a subject in need thereof, e.g., with a damaged myocardium. The methods, composition and kits of the invention can be used to treat cardiovascular diseases such as heart failure, myocardial infarction and an age-related cardiomyopathy..
Aal Scientifics, Inc.

Enalapril formulations

Provided herein are stable enalapril oral liquid formulations. Also provided herein are methods of using enalapril oral liquid formulations for the treatment of certain diseases including hypertension, heart failure and asymptomatic left ventricular dysfunction..
Silvergate Pharmaceuticals, Inc.

Methods of steering and delivery of intravascular devices

A method of delivering a rigid intravascular device to a target location in a patient's heart includes positioning a distal tip of an elongated member of the intravascular device delivery system in a right atrium of a heart and moving the distal tip of the elongated member into a left atrium of the heart. The method includes advancing an inner steerable catheter of the elongated member longitudinally distally relative to an outer sleeve of the elongated member a first longitudinal distance; deflecting at least a portion of the inner steerable catheter a first deflection amount; then advancing an inner steerable catheter of the elongated member longitudinally distally relative to an outer sleeve of the elongated member a second longitudinal distance; and then deflecting at least a portion of the inner steerable catheter a second deflection amount..

Repositionable endoluminal support structure and its applications

A prosthetic heart valve includes a frame, a valve component, and a skirt. The frame has first and second end portions, a central longitudinal axis extending between the first and second end portions, and a plurality of struts interconnected by a plurality of joints.
Edwards Lifesciences Cardiaq Llc

Heart valve prosthesis and separate support flange for attachment thereto

A valve prosthesis assembly for implantation into a native valve site. The valve prosthesis assembly includes a valve prosthesis with a prosthetic valve component and a frame.
Medtronic Vascular, Inc.

Prosthetic heart valve devices and methods of valve replacement

A stented valve having at least one leaflet made of pericardium or other material having a relatively thin profile at the annulus. The leaflets are attached via chords to a stent frame, where the chords are positioned to mimic the native valve anatomy and functionality.
Medtronic, Inc.

Prosthetic heart valve with paravalvular leak mitigation features

A prosthetic heart valve includes a collapsible stent and a valve assembly disposed within the stent. A first cuff is disposed adjacent the stent.
St. Jude Medical, Cardiology Division, Inc.

Heart valve docking system

Docking devices can be configured to be positioned at a native valve of a human heart to provide structural support for docking a prosthetic valve. The docking devices generally have coiled structures that define an inner space in which the prosthetic valve can be held.
Edwards Lifesciences Corporation

Multi-portion replacement heart valve prosthesis

A replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame.
Edwards Lifesciences Corporation

Heart valve docking coils and systems

Anchoring or docking devices configured to be positioned at a native valve of a human heart and to provide structural support for docking a prosthetic valve therein. The docking devices can have coiled structures that define an inner space in which the prosthetic valve can be held.
Edwards Lifesciences Corporation

Perivalvular occlusion device and methods

An occlusion device intended for blocking perivalvular leak channels that are found following heart valve implantation between the heart valve and the surrounding tissue. The occlusion device has a stent and a covering that is attached to the stent surface.

Method and system for image processing to determine blood flow

Systems and methods are disclosed for evaluating cardiovascular treatment options for a patient. One method includes creating a three-dimensional model representing a portion of the patient's heart based on patient-specific data regarding a geometry of the patient's heart or vasculature; and for a plurality of treatment options for the patient's heart or vasculature, modifying at least one of the three-dimensional model and a reduced order model based on the three-dimensional model.
Heartflow, Inc.

Apparatus and intra-cardiac mapping and ablation

An intra-cardiac mapping system is based on locating the ports through which blood flows in or out the heart chambers. For many procedures, such as ablation to cure atrial fibrillation, locating the pulmonary veins and the mitral valve accurately allows to perform a maze procedure.
Kardium Inc.

Jugular access left atrial appendage closure device

A left atrial appendage closure device system may include an access sheath having a lumen, a delivery sheath slidably disposed within the lumen of the access sheath, and a left atrial appendage closure device slidably disposed within a distal portion of the delivery sheath. The access sheath may include a pre-curved portion adjacent a distal tip of the access sheath.
Cardiac Pacemakers, Inc.

Transcatheter aortic valve implantation assembly with integrated imager

A transcatheter aortic valve implantation (tavi) delivery system includes a sheath, a replacement valve assembly disposed within a distal end of the sheath, and a nose cone proximate the distal end of the sheath. A forward section of the nose cone is configured to facilitate passage of the nose cone through the heart valve.
Tyco Electronics Corporation

Safety monitoring with wearable devices

Disclosed herein are system, method, and computer program product embodiments for detecting an irregularity in a user's vital signs and alerting of a potential emergency using wearable devices. An embodiment operates by receiving, from a sensor component coupled to a wearable computing device, real-time heart rate information associated with a user wearing the wearable computing device.
Zoi Inc.

System and health monitoring including a user device and biosensor

A biosensor unit is coupled to a user device and may communicate with the user device over a short range wireless or wired interface. The biosensor unit includes an optical sensor used to obtain an oxygen saturation level, a heart rate and a respiration rate of a user.
Sanmina Corporation

Exercise test evaluation system, exercise test evaluation apparatus, exercise test evaluation method, and non-transitory computer readable recording medium

An exercise test evaluation system includes an acceleration sensor that is worn by a user during an exercise test and acquires acceleration values of a foot of the user, a heart rate sensor that is worn by the user and measures a heart rate of the user, and a processor. The processor acquires a first maximum acceleration value and a second maximum acceleration value, calculates a reliability score using the first and second maximum acceleration values, acquires a walking velocity and a heart rate of the user and estimates a maximum oxygen intake amount using the user's walking velocity and heart rate if the reliability score is equal to or higher than a specific threshold value, and estimates the maximum oxygen intake amount using the user's walking velocity if the reliability score is lower than the specific threshold value..
Panasonic Intellectual Property Management Co., Ltd.

Amplitude spectrum area considerations for an external medical monitoring and treatment device

A medical monitoring and treatment device that includes a therapy delivery interface, a plurality of therapy electrodes coupled to the therapy delivery interface, a plurality of electrocardiogram sensing electrodes to sense electrocardiogram signals of a patient, a sensor interface to receive the electrocardiogram signals and digitize the electrocardiogram signals, and at least one processor coupled to the sensor interface and the therapy delivery interface to analyze the digitized electrocardiogram signals, to detect a cardiac arrhythmia based on the digitized electrocardiogram signals, and to control the therapy delivery interface to apply electrical therapy to the patient based upon the detected cardiac arrhythmia. The at least one processor is further configured to analyze a frequency domain transform of the digitized electrocardiogram signals, to determine a metric indicative of a metabolic state of a heart of the patient, and to accelerate or delay application of the electrical therapy based upon the metric..
Zoll Medical Corporation

Detecting unmeasurable loads using heart rate and work rate

A method and a system for determining an energy expenditure of a user by detecting unmeasurable loads using heart rate and work rate are described. Time-stamped heart rate data and work rate data can be collected by one or more sensing modules.
Apple Inc.

Quantitative differentiation of inflammation from solid tumors, heart and nerve injury

D-histo, a non-invasive diagnostic method, renovated from diffusion basis spectrum imaging (dbsi) is provided for quantitatively detecting and distinguishing inflammation from solid tumors, heart and nerve injury. For example, the d-histo methods disclosed herein provide an accurate diagnosis of prostate cancer, distinguishing it from prostatitis and bph that missed by currently available methods of diagnosing prostate cancer (multiparameter mri, needle biopsy).
Washington University

Methods and systems for therapeutic neuromodulation

Systems, methods and computer-readable media are disclosed for providing therapeutic auditory stimulation. Consistent with disclosed embodiments, a system for providing therapeutic auditory stimulation may comprise a diagnostic unit that computes an eeg spectral density of a patient and a heart rate spectral density of a patient and provides values for one or more eeg frequency bands and one or more heart rate frequency bands.
Biosensor, Inc.

System and methods for assessing heart function

Systems and methods can be used to provide an indication of heart function, such as an indication of mechanical function or hemodynamics of the heart, based on electrical data. For example, a method for assessing a function of the heart can include determining a time-based electrical characteristic for a plurality of points distributed across a spatial region of the heart.
Cardioinsight Technologies, Inc.

System and assessing electrical activity using an iterative sparse technique

Three-dimensional electrical source imaging of electrical activity in a biological system (e.g., brain or heart) may involve sensor array recording, at multiple locations, of signals (e.g. Electrical or magnetic signals) of electrical activity.
Regents Of The University Of Minnesota

Electronic device and measuring heart rate based on infrared rays sensor using the same

A method for determining a heart rate (hr) using an infrared rays (ir) sensor and an electronic device is provided. An image is received using an ir sensor, at least one region of interest (roi) for measuring the hr is determined in the received image, and the hr is determined based on the at least one determined roi..
Samsung Electronics Co., Ltd.

Automatic estimation of pulse deficit

Methods, systems, and devices for determining pulseless electrical activity (pea) are described. The method may include determining by using a first sensor on a person, a heart rate of the person based on sensed electrical activity of the person.
Covidien Lp

Method and device for computing optical hemodynamic blood pressure

Device for measuring blood pressure hemodynamically in blood vessels at one or more body locations comprising light source; at least three sensors including an array of at least three optical sensors, for receiving light and for obtaining a signal over time comprising temporal per pixel information for at least two wavelengths of light, and corresponding to a flow of blood within a blood vessel over time; a processing unit configured to receive the signal and generate a continuous dynamic blood pressure reading by using the temporal per pixel information for the at least two wavelengths of light to produce heart rate signals from the blood flow, and by applying a modified windkessel model on the signal such that the blood pressure also depends on a spatial temporal pressure resistance function over time that depends on a body location of the blood flow over time, the pressure resistance function representing elastance/stiffness.. .
Cnoga Medical Ltd.

Body-worn sensor for characterizing patients with heart failure

The invention provides a sensor for measuring both impedance and ecg waveforms that is configured to be worn around a patient's neck. The sensor features 1) an ecg system that includes an analog ecg circuit, in electrical contact with at least two ecg electrodes, that generates an analog ecg waveform; and 2) an impedance system that includes an analog impedance circuit, in electrical contact with at least two (and typically four) impedance electrodes, that generates an analog impedance waveform.
Tosense, Inc.

Systems and methods for determining an intensity level of an exercise using photoplethysmogram (ppg)

Disclosed systems and methods relate to determining an intensity level of an exercise using a photoplethysmogram (ppg) sensor. A method of determining an intensity level of an exercise for a user according to one embodiment of the present disclosure includes detecting, by a device, body signals from the user using a ppg sensor.
Apple Inc.

Device and the geometric determination of electrical dipole densities on the cardiac wall

Disclosed are devices, systems, and methods for determining the dipole densities on heart walls. In particular, a triangularization of the heart wall is performed in which the dipole density of each of multiple regions correlate to the potential measured at various located within the associated chamber of the heart.
Acutus Medical, Inc.

Monitoring device to identify candidates for autonomic neuromodulation therapy

A monitoring system and method for measuring and analyzing physiological signals to assess whether neuromodulation therapy would be successful for a patient. The system includes an external patch device that can be adhered to the chest of the patient in order to measure physiological signals, including heart signals via ecg and respiration via impedance measurement.
Biotronik Se & Co. Kg.

System and detecting active streams using a heartbeat and secure stop mechanism

One embodiment of the present invention sets forth a technique for identifying active streaming connections associated with a particular user account. Each active streaming connection transmits heartbeat packets periodically to a server that tracks the receipt of the heartbeat packets.
Netflix, Inc.

Baby monitor

Systems and methods are described herein for monitoring and capturing information associated with target subjects, such as babies. For example, the systems and methods provide a capture device, such as a camera, that captures capture time of flight (tof) data from a target subject.
Egw Technologies Llc

Baby monitor

Systems and methods are described herein for monitoring and capturing information associated with target subjects, such as babies. For example, the systems and methods provide a capture device, such as a camera, that captures capture time of flight (tof) data from a target subject.
Egw Technologies Llc

End of service summary report for mobile cardiac outpatient telemetry

A method for filtering ecg data includes receiving ecg data of a patient, generating an ecg report comprising a plurality of pages, and presenting priority information on a first page of the plurality of pages. The priority information includes information identifying the patient, monitoring summary information including an indication of a total duration of a monitoring period, heart rate summary information including an average heart rate, a fastest heart rate, and a slowest heart rate, representative arrhythmia summary information including a count of ecg strips containing each of a plurality of types of cardiac arrhythmia, and atrial fibrillation summary information including an indication of atrial fibrillation burden during the monitoring period.
Braemar Manufacturing, Llc

Method of producing galvannealed steel sheet

A method of producing a galvannealed steel sheet whereby favorable coating appearance can be obtained with high coating adhesion even in the case of galvannealing a steel strip whose si content is 0.2 mass % or more, and a decrease in tensile strength can be prevented by lowering the alloying temperature. Mixed gas of humidified gas and dry gas, and dry gas are supplied to a soaking zone in an annealing furnace.
Jfe Steel Corporation

Vehicle data selection system for modifying automated driving functionalities and method thereof

The systems and methods provided herein are directed to the uploading and transmission of vehicle data to a remote system when a physiological event for a driver has been detected using one or more sensors. Information such as the driver's heart rate, temperature, voice inflection or facial expression may be monitored to detect the physiological event.
Honda Motor Co., Ltd.

Vehicle occupant detection system

A living vehicle occupant detection system has a control unit that is mounted within a vehicle, a temperature sensor which is mounted within the interior passenger compartment of the vehicle and is communicatively coupled (either wired or wirelessly) to the control unit, and a life detection unit that will indicate the presence and location of a heartbeat within the interior of the vehicle and that is communicatively coupled (either wired or wirelessly) to the control unit. A carbon monoxide (co) sensor may also be installed within the interior of the vehicle to optimize co detection and is coupled (either wired or wirelessly) to the control unit..

Pose and heart rate energy expenditure for yoga

A method and a system for determining an energy expenditure of a user while practicing yoga are described. A heart rate sensing module can measure the user's heart rate.
Apple Inc.

Low-energy defibrillation with nanosecond pulsed electric fields

Methods for terminating fibrillation in a fibrillating heart employing nanosecond pulsed electric fields (nspefs) are disclosed. Nspef defibrillation demonstrates its effectiveness as a new defibrillation modality, achieving reliable defibrillation with energies that are an order of magnitude lower than those needed for conventional defibrillation (millisecond shocks with mono- and bi-phasic waveforms).
Old Dominion University Research Foundation

Trans septal implantable medical device

An implantable medical device (imd) includes a housing that is configured to be positioned at least in part in a chamber of a heart, and in some cases, in a right ventricle (rv) proximate an rv facing side of the ventricular septum of the heart. When so provided, an rv electrode may be fixed relative to the housing to be proximate the rv facing side of the ventricular septum.
Cardiac Pacemakers, Inc.

Cardiac modulation facilitation methods and systems

A method of facilitating therapeutic neuromodulation of a heart of a patient includes positioning an electrode in a pulmonary artery, positioning a sensor in vasculature, delivering via a stimulation system first and second electrical signals of a series of electrical signals to the electrode. The second electrical signal differs from the first electrical signal by a magnitude of a first parameter of a plurality of parameters.
Cardionomic, Inc.

Cardiac pacing

A cardiac pacing system that includes an implantable pulse generator and electrical leads that include a lead body portion having a distal end and a proximal end, a connector configured to electrically connect the proximal end of the lead body to the pulse generator, and at least one electrode disposed at the distal end of the lead body for delivering electrical stimulation to a patient's heart, wherein the distal end of the lead body is configured to terminate within the mediastinum of the thoracic cavity of the patient, proximate to the heart.. .
Atacor Medical, Inc.

Method of using an intra-esophageal balloon system

A method is disclosed for selective inflation of an inflatable body, such as a balloon, received through an oral cavity and into the esophagus of a patient. The inflatable body is operably coupled to a pressurized fluid source.
Niazi Licensing Corporation

Heart pump cuff

At least some embodiments of the disclosure may advantageously limit bleeding and the occurrence of blood leaks after heart pump implantation. In some embodiments, a base may be provided that includes a flexible layer mechanically coupled with a conduit.
Tc1 Llc

Pluripotent stem cell that induces repair and regeneration after myocardial infarction

An object of the present invention is to provide a novel medical application for use in regenerative medicine that uses pluripotent stem cells (muse cells). The present invention provides a cell preparation for treating myocardial infarction, and particularly serious massive myocardial infarction and heart failure associated therewith, that contains pluripotent stem cells positive for ssea-3 isolated from biological mesenchymal tissue or cultured mesenchymal cells.
Tohoku University

Preeclampsia

The invention provides a method of treating preeclampsia, fetal growth restriction (fgr or iugr), obesity in pregnancy, post-partum cardiomyopathy (heart failure in mothers), cancer and diabetic retinopathy, cardiomyopathy, myocardial infarction, wet microdegeneration and other disorders where angiogenesis is aberrant either diminished or exacerbated, comprising modulating the activity of micro rna (mirna). Also provided are an mirna modulator or a combination thereof or functional fragments or homologues thereof for use in the treatment of preeclampsia, fetal growth restriction, obesity in pregnancy, cancer, and diabetic retinopathy, cardiomyocyte infarction, wet microdegeneration as well as other disorder where angiogenesis is aberrant either diminished or exacerbated.
Aston University

Sizing device and positioning a prosthetic heart valve

A sizing device for a collapsible prosthetic heart valve includes a collapsible and expandable stent. The stent has an annulus section at a first end with a first diameter and an aortic section at a second end with a second diameter.
St. Jude Medical, Cardiology Division, Inc.

Heart valve regurgitation anchor and delivery tool

A heart valve anchor apparatus may include a body having a proximal portion and a distal portion. The body may include a first radially expandable portion at the proximal portion of the body, a second radially expandable portion at the distal portion of the body, and a root portion extending from the first radially expandable portion to the second radially expandable portion, the root portion having an outer extent.
Mayo Foundation For Medical Education And Research

Prosthetic heart valve with retention elements

Described embodiments are directed toward centrally-opening leaflet prosthetic valve devices having a leaflet frame and a leaflet construct. The leaflet construct is at least partially coupled to a leaflet frame outer side of the leaflet frame and being coupled thereto by a retention element..
W. L. Gore & Associates, Inc.

Prosthetic heart valve formation

A prosthetic heart valve includes a base and a plurality of polymeric leaflets. Each leaflet has a root portion coupled to the base, and each leaflet has an edge portion substantially opposite the root portion and movable relative to the root portion to coapt with a respective edge portion of at least one of the other leaflets of the plurality of leaflets.
Boston Scientific Scimed, Inc.

Transcatheter valve replacement

A prosthetic heart valve having an inflow end and an outflow end includes a collapsible and expandable stent, a collapsible and expandable valve assembly disposed within the stent and having a plurality of leaflets, and a deformable frame having a first end and a second end. The frame includes braided wires forming a body having a lumen extending therethrough for receiving the stent and the valve assembly, the body having a plurality of diameters from the first end to the second end..
St. Jude Medical, Cardiology Division, Inc.

Preventing non-target embolization

Devices, methods and kits for preventing or reducing non-target microparticles deposition and embolization, in conjunction with delivering microparticles (e.g., embolization material) via a blood vessel to a target bodily part. Applicable for entrapping infiltrated microparticles within heart right atrium.
Accurate Medical Therapeutics Ltd.

Subxiphoid connective lesion ablation system and method

Instrument and systems for applying ablative energy to epicardial tissue via a subxiphoid access surgical approach. The instrument has a head assembly sized and shaped for a subxiphoid surgical approach to a patient's heart and defines a contact face.
Medtronic, Inc.

Ultrasonic diagnosis of cardiac performance by single degree of freedom chamber segmentation

An ultrasonic diagnostic imaging system has a user control by which a user positions the user's selection of a heart chamber border in relation to two machine-drawn heart chamber tracings. The user's border is positioned by a single degree of freedom control which positions the border as a function of a single user-determined value.
Koninklijke Philips N.v.

Mattress for resting or sleeping of a person

A mattress for resting or sleeping of a person includes a sensor arranged in connection with the mattress for determining the heart rate and/or the heart rate variation and/or breathing disturbances and/or the respiratory frequency and/or the categories of sleep that are affected by the person's movements and/or micromovements. An electronic unit is connected to the sensor with a cable.
Emfit Oy

Systems and methods for determining individualized energy expenditure

A method and a system for determining an individual energy expenditure are described. In some embodiments, an energy expenditure can be calculated based on a combination of biometrics, heart rate and work rate.
Apple Inc.

Sleep tracking systems, methods, and devices

Provided are mechanisms and processes for tracking sleep. Devices may include an accelerometer configured to measure macro and micro sensitivity movement of head, movement of throb of vessels close to the ear, monitor changes in heart rate and pulse rate and blood pressure.

Heartbeat detecting device and biological signal processing device

The difference between the current value and the last value of an rr interval is compared with a predetermined reference differential value, and an attenuation time constant of a peak-hold section is controlled according to the comparison result.. .
Ai Technology Inc.

Electronic system to control the acquisition of an electrocardiogram

It is disclosed an electronic system to control the acquisition of an electrocardiogram. The system comprises a portable electronic device and a mobile electronic device.
D-heart S.r.l.

Systems and methods for variable filter adjustment by heart rate metric feedback

A physiological signal processing system for a physiological waveform that includes a cardiovascular signal component provides a variable high pass filter that is responsive to the physiological waveform, and that is configured to high pass filter the physiological waveform in response to a corner frequency that is applied. A heart rate metric extractor is responsive to the variable high pass filter and is configured to extract a heart rate metric from the physiological waveform that is high pass filtered.
Valencell, Inc.

Crumbling caloric stockpile tracker

A fitness system may include a mobile device configured to, in response to receiving a caloric depletion rate based on data received from an activity tracker and a current food article having a caloric value, display a depiction of the food article defined by a difference between the caloric value and an aggregated caloric depletion based on the caloric depletion rate. The caloric depletion rate may include a basal metabolic rate.

Wireless radio module

According to one aspect, there is provided a wireless radio module comprising a millimeter wave wireless communication transceiver configured to output radar signals for physiological measurement, a millimeter wave antenna array connected to the millimeter wave wireless communication transceiver and configured to transmit the radar signals and to receive reflected radar signals, and a processing unit configured to analyze the received reflected radar signals to determine changes in a spectrum reflecting at least one of heart rate or respiration.. .
Microsoft Technology Licensing, Llc

Weight scale and corresponding preventing advancement of congestive heart failure

A weight scale (100) for assisting with management of congestive heart failure and other ailments includes a housing (101) that can define a substantially flat planar surface (102). A weight measurement device (202) measures a weight of a user.
Medline Industries, Inc.

Diastolic endocardial accelerations for heart failure monitoring

Systems and methods for monitoring patients with cardiac diseases are described. A system may include an accelerometer sensor for sensing an epicardial or endocardial acceleration (ea) signal.
Cardiac Pacemakers, Inc.

Femoral arterial cannula capable of guiding bidirectional perfusion flow

The present invention relates to a cannula for femoral arterial bidirectional (a heart direction and a distal lower extremity direction) perfusion. The cannula, which has a cannula tube to be inserted into a blood vessel of the femoral artery, includes a perfusion guide channel formed as a concave part from a predetermined portion of an inner circumferential surface at an end of the cannula tube to the opposite end thereof in a length direction and further includes a through-hole provided at a boundary portion between the perfusion guide channel and the cannula tube in an end direction of the cannula tube, or includes a through-hole provided in a predetermined portion of to an inner circumferential surface of an end of the cannula tube and a guide cover provided at an upper portion of the through-hole to cover the upper portion of the through-hole and guide perfusion.
Samsung Life Public Welfare Foundation

Systems and methods to reduce injury in the heart

This document discusses, among other things, systems and methods to reduce ischemic or metabolic injury to a patient's heart. A system to reduce ischemic or metabolic injury to a patient's heart may include a pulse generator for generating electrical pulses or shock, a pacing lead with at least one pacing electrode configured to deliver electrical pulses received from the pulse generator to the patient's heart, a controller configured to control timing of electrical pulses to reduce wall stress of the heart, and a reservoir, fluidically coupled to a lumen and a pump, wherein the pump is configured, under control of the controller, to move contents from the reservoir through the lumen to an area of the heart with the reduced wall stress, wherein the contents include autologous respiration-competent mitochondria or other respiratory-promoting agents..
Cardiac Pacemakers, Inc.

Mesh enclosed tissue constructs

A heart valve leaflet including a thermoplastic polyurethane (tpu) mesh material that has a stiffness that is comparable to a native heart valve leaflet, such that it functionally mimics a native heart valve leaflet. The heart valve leaflets optionally include one to three layers of cells cultured on each side of the mesh material.
The Regents Of The University Of California

Methods and compositions for preventing and treating damage to the heart

Provided herein are methods and compositions for preventing and treating damage to the heart subsequent to myocardial infarction (mi) resulting from harmful fibrotic remodeling, thereby improving cardiac function and reducing mortality from subsequent heart failure.. .
The Regents Of The University Of California

Novel methods

Provided are uses of selective aquaporin inhibitors, e.g., of aquaporin-4 or aquaporin-2, e.g., certain phenylbenzamide compounds, for the treatment or prophylaxis of transplant rejection and the protection of the heart during heart surgery. Provided is the use of selective aquaporin inhibitors, e.g., of aquaporin-4 (aqp4) or aquaporin-2 (aqp2) for the treatment or prophylaxis of transplant rejection and for the protection of the heart during heart surgery..
Aeromics, Inc.

Devices and methods for the treatment of heart valve insufficiencies

Disclosed herein are various embodiments directed to a device for minimally invasive medical treatment. The device being a hollow tube with a first end, a second end, and one or more anchors configured to extend outward from the exterior of the hollow tube.
Valcare, Inc.

Collapsible cardiac implant and deployment system

A collapsible device, such as an annuloplasty ring or prosthetic heart valve, is configured to be collapsed prior to being introduced into a patient via minimally-invasive access points such as port holes or intercostal incisions. A holder is configured to hold the collapsible device, and to selectively collapse the device for introduction into the patient and then re-enlarge the device at the desired deployment site.
Edwards Lifesciences Corporation

Heart chamber prosthetic valve implant with elevated valve section and single chamber anchoring for preservation, supplementation and/or replacement of native valve function

Various embodiments of the present invention comprise a single-chamber collapsible and expandable prosthetic valve implant device with an elevated valve section and comprising the following capabilities: (1) preservation of native valve functionality; (2) initial preservation of native valve functionality with subsequent full replacement of native valve functionality; (3) full replacement of native valve functionality; and/or (4) mitigation of the prolapsing distance of the dysfunctional leaflets by preventing the anterior excursion of the prolapsing leaflets above the upper annular surface and into the left atrial chamber in order to preserve native leaflet functionality for as long as possible. The expanded and implanted device does not extend beyond the boundaries of the subject heart chamber, e.g., the left atrium, thereby enabling the preservation of any remaining native valve functionality with subsequent full replacement of native valve functionality if and when needed..
4c Medical Technologies, Inc.

Heart chamber prosthetic valve implant with base, spring and dome sections with single chamber anchoring for preservation, supplementation and/or replacement of native valve function

Various embodiments of the present invention comprise a single-chamber collapsible and expandable prosthetic valve implant device comprising the following capabilities: (1) preservation of native valve functionality; (2) initial preservation of native valve functionality with subsequent full replacement of native valve functionality; (3) full replacement of native valve functionality; and/or (4) mitigation of the prolapsing distance of the dysfunctional leaflets by preventing the anterior excursion of the prolapsing leaflets above the upper annular surface and into the left atrial chamber in order to preserve native leaflet functionality for as long as possible. The expanded and implanted device does not extend beyond the boundaries of the subject heart chamber, e.g., the left atrium, thereby enabling the preservation of any remaining native valve functionality with subsequent full replacement of native valve functionality if and when needed..
4c Medical Technologies, Inc.

Heart chamber prosthetic valve implant with base, mesh and dome sections with single chamber anchoring for preservation, supplementation and/or replacement of native valve function

Various embodiments of the present invention comprise a single-chamber collapsible and expandable prosthetic valve implant device comprising the following capabilities: (1) preservation of native valve functionality; (2) initial preservation of native valve functionality with subsequent full replacement of native valve functionality; (3) full replacement of native valve functionality; and/or (4) mitigation of the prolapsing distance of the dysfunctional leaflets by preventing the anterior excursion of the prolapsing leaflets above the upper annular surface and into the left atrial chamber in order to preserve native leaflet functionality for as long as possible. The expanded and implanted device does not extend beyond the boundaries of the subject heart chamber, e.g., the left atrium, thereby enabling the preservation of any remaining native valve functionality with subsequent full replacement of native valve functionality if and when needed..
4c Medical Technologies, Inc.

Two stage cellularization strategy for the fabrication of bioartificial hearts

In some embodiments, the present disclosure pertains to a method of fabricating an artificial heart muscle (ahm) patch. In some embodiments, the method comprises obtaining and/or isolating cells from a subject.
University Of Houston System

Bioprosthetic heart valves having adaptive seals to minimize paravalvular leakage

A packaged bioprosthetic heart valve comprising a bioprosthetic heart valve, an adaptive seal and a package. The bioprosthetic heart valve comprises an at least partially dehydrated biological tissue leaflet structure coupled to a supporting frame.
Edwards Lifesciences Corporation

Apparatus and intra-cardiac mapping and ablation

An intra-cardiac mapping system is based on locating the ports through which blood flows in or out the heart chambers. For many procedures, such as ablation to cure atrial fibrillation, locating the pulmonary veins and the mitral valve accurately allows to perform a maze procedure.
Kardium Inc.

Medical processing apparatus, ultrasound diagnostic apparatus, and medical processing method

According to one embodiment, a medical processing apparatus according to an embodiment includes processing circuitry. The processing circuitry acquires a body mark that schematically shows a positional relationship of a plurality of structures in a heart.
Toshiba Medical Systems Corporation

Dual energy x-ray coronary calcium grading

Methods and apparatus for grading coronary calcium, including an example apparatus that includes a set of logics and a memory that stores a set of radiographic images. The set of logics includes an image acquisition logic that acquires a set of radiographic images of a region of tissue, the set of radiographic images including a low-energy reference x-ray image and a higher-energy floating x-ray image, a registration logic that produces a set of registered images from a plurality of members of the set of radiographic images, an enhancement logic that produces a set of calcium-enhanced images from the set of registered images, a post-enhancement logic that produces a bone image from the set of calcium-enhanced images, and a grading logic that computes a coronary heart disease prediction score based, at least in part, on the bone image and a set of features extracted from the bone image..
Case Western Reserve University

Sensors for prosthetic heart devices

Prosthetic heart devices may be implanted into the heart with a sensor coupled to the device, the sensor being configured to measure physiological data, such as blood pressure, in the heart. Devices that may employ such sensors include prosthetic heart valves and occlusion devices, although sensor systems may be deployed in the heart separate from other implantable devices.
St. Jude Medical, Cardiology Division, Inc.

Optical monitoring apparatus and methods

An apparatus includes a digital camera configured to capture a plurality of images of a region of a body of a subject, a photoplethysmography (ppg) sensor configured to sense blood flow information from the subject, and a processor in communication with the digital camera and the ppg sensor. The processor is configured to analyze a blood flow information signal from the ppg sensor and determine a heart rate frequency and/or a breathing rate frequency of the subject.
Valencell, Inc.

Method for recording diagnostic measurement data of a heart of an examination object in a heart imaging by means of a magnetic resonance device

A method is disclosed for recording diagnostic measurement data of a heart of an examination object in a heart imaging via a magnetic resonance device. In an embodiment, the method for recording diagnostic measurement data of a heart of an examination object in a heart imaging, via a magnetic resonance device, includes carrying out of at least two overview recordings of the heart of the examination object, wherein overview measurement data is acquired; and carrying out of at least two diagnostic recordings of the heart of the examination object based on the acquired overview measurement data.
Siemens Healthcare Gmbh

Identifying ecg signals having the same morphology

A method, including selecting an initial set of electrocardiograph (ecg) signals taken over a single heartbeat of a human subject, the set having respective morphologies to be used as a template for an arrhythmia of the subject, and receiving a subsequent set of ecg signals taken over a subsequent heartbeat of the human subject. The method also includes performing a cross-correlation between the initial set and the subsequent set, so as to generate a correlation coefficient that is a measure of a goodness of fit between geometries of the initial set and the subsequent set, and, when the correlation coefficient exceeds a threshold coefficient, accepting the subsequent heartbeat as having been caused by the arrhythmia..
Biosense Webster (israel) Ltd.

System and rotor detection in cardiac fibrillation

Various embodiments are described herein for detecting a rotor at a location of a heart that experiences cardiac fibrillation. This generally involves obtaining a plurality of bipolar egms for a recording duration using a circular bipolar electrode array positioned at the location of the heart; detecting a dominant periodicity cycle length (cl) and identifying periodic activations for each bipolar egm associated with the dominant periodicity cl; tracking the identified periodic activations across each bipolar egm to define rotational activations and determining when a path taken by the tracked rotational activations corresponds to a rotational activation pattern of a rotor; and detecting the rotor when a number and completeness of the tracked rotational activations meet predefined rotor criteria..
University Health Network

Episodical and continuous ecg monitoring

Monitoring heart activity using a wearable device, including receiving, from the wearable device, an electrocardiograph (ecg) signal and a motion signal associated with an individual upon contact with the wearable device; in response to receiving the ecg signal and the motion signal associated with the individual, determining, by a computing device, a position of the wearable device in contact with the individual; and determining, by the computing device, a heart activity monitoring mode for operating the wearable device, based on the position of the wearable device in contact with the individual.. .
Huami Inc.

Method and terminal for obtaining fetal heart

A method for obtaining fetal heart rate which includes: transmitting an ultrasonic pulse wave towards an abdomen of a pregnant woman according to a preset period; receiving a pulse echo and a fetal heart echo corresponding to the ultrasonic pulse wave in each period, and processing the pulse echo and the fetal heart echo independently to obtain a corresponding pulse rate of the pregnant woman and the fatal heart rate; outputting the fetal heart rate when a difference value between the fetal heart rate and the pulse rate of the pregnant woman is not lower than a preset threshold. Furthermore, a system and an apparatus for obtaining fetal heart rate are also provided.
Edan Instruments, Inc.

Heart mapping system

A method of determining physiological information for an internal body surface using an open catheter comprising multiple sensors. Sensor potentials are obtained and used to determine catheter potentials within the catheter, and the physiological information for the internal body surface is determined using at least some of the catheter potentials..
Shu Ming

Controlling audio tempo based on a target heart rate

A method for controlling an audio output comprises playing a first audio file having a first tempo, measuring a first heart rate of a user, determining whether the first heart rate of the user is greater than a target heart rate, and playing a second audio file having a second tempo, the second tempo is slower than the first tempo, responsive to determining that the first heart rate of the user is greater than the target heart rate.. .
International Business Machines Corporation

Adaptor to allow electrogram visualization and pacing from temporary epicardial wires

A connector block that permits simultaneous and continuous interconnection of the three leads of the epicardial pacing wires, the pacemaker, and the ecg monitor on clear separately labeled connectors is provided. Circuitry is provided that allows the display of epicardial signals on the telemetry unit, while still preserving the ability to pace the heart from the pacemaker.
Wisconsin Alumni Research Foundation

System and locating a catheter tip

A system for locating the tip of a catheter inside a human body is provided. The system includes a sound sensor for sensing the magnitude wave form generated by sound pressure as a picc is progressed toward a heart of a patient; and monitoring means operably coupled to the sensor for measuring the magnitude of wave form generated by the sound sensor..

Realtime feedback response system and methods of using the same

Provided herein are apparatus and methods of relaxation. In particular, disclosed herein includes a system that provides realtime or near realtime feedback response to a user in order to achieve a relaxation response.

Systems and methods for treating pulmonary hypertension

A system for treating heart disease, such as pulmonary hypertension or right heart failure, including an implantable component and external components for monitoring the implantable component is provided. The implantable component may include a compliant member, e.g., balloon, coupled to a reservoir via a conduit.
Aria Cv, Inc.

Therapeutic mirnas for treating heart and skeletal muscle diseases

The present disclosure describes the role for mir-322(424)/503 in the differentiation of cardiac precursor cells. Thus, the use of these molecules in the programming of resident stem/progenitor cells into cardiomyocytes, both in vitro and in vivo.
University Of Houston System

Use of nadph in preparing medicines for treatment of heart diseases

The use of reduced nicotinamide adenine dinucleotide phosphate (nadph) in preparing medicines for the treatment of heart diseases, and medicines for the treatment of heart diseases using nadph as the active ingredient, said heart diseases including cardiac damage, myocardial infarction, and cardiomyopathy.. .
Chongqing Institute Of Bench-to Bed Bioengineering Technology Co., Ltd.

Devices for remodeling a valve annulus and ventricle

Devices and related methods of use are provided for improving heart function. In one embodiment of the present disclosure, a device includes a ring-like structure configured to be secured to a heart valve; at least one elongate member extending from the ring-like structure, wherein an end of the elongate member is configured to be secured to heart geometry other than a heart valve; and an adjustment mechanism for simultaneously altering a dimension of the ring-like structure and a length of the elongate member..
Edwards Lifesciences Corporation

Delivery system with inline sheath

Systems and methods for delivering and implanting heart valves are disclosed. The delivery systems can include an integrated introducer.
Medtronic, Inc.

Delivery systems for prosthetic heart valve

A delivery apparatus for a prosthetic heart valve includes a shaft, an inner balloon, and an outer balloon. The shaft has a lumen extending from a proximal end portion to a distal end portion and a plurality of openings formed in the distal end portion.
Edwards Lifesciences Corporation

Delivery devices for implantable medical devices and methods of manufacturing same

This disclosure describes, among other things, methods, devices, and systems for non-invasive evaluation of a patient's vascular system and custom design and manufacture of one or more components of a delivery device for delivery and deployment of an implantable medical device, such as a prosthetic heart valve. For example, a delivery sheath can be 3d printed to have varying durometers at one or more areas along its length and/or circumference so that it can more easily bend and flex as it traverses particularly tortuous anatomical features..
Medtronic Vascular, Inc.

Valve leaflet attachment in collapsible prosthetic valves

A prosthetic heart valve includes a stent having a collapsed condition and an expanded condition. The stent includes a plurality of cells, each cell being formed by a plurality of struts, and a plurality of commissure features.
St. Jude Medical, Cardiology Division, Inc.

Prosthetic heart valve using pericardium and manufacturing same

A prosthetic heart valve using a pericardium is disclosed where: three hetero-biological tissue slices, which are extracted in a quadrangular shape from a bovine pericardium or a porcine pericardium, are prepared; each hetero-biological tissue slice is folded so as to form an inner tissue slice inside and an outer tissue slice outside, the outer tissue slice being longer than the inner tissue slice; each of the inner tissue slice and outer tissue slice is coupled by sewing in a semicircular shape with a first coupling thread such that each inner tissue slice forms a pulmonic valve slice inside the first coupling thread and a fixing slice outside the first coupling thread such that each hetero-biological tissue slice is formed in a cylindrical shape by allowing each slice to be adjacent to each other. The disclosed prosthetic heart valve has increased durability and prevents reverse blood flow..
Taewoong Medical Co., Ltd.

Medical device for use in bodily lumens, for example an atrium

A device positionable in a cavity of a bodily organ (e.g., a heart) may discriminate between fluid (e.g., blood) and non-fluid tissue (e.g., wall of heart) to provide information or a mapping indicative of a position and/or orientation of the device in the cavity. Discrimination may be based on flow, or some other characteristic, for example electrical permittivity or force.
Kardium Inc.

Medical device for use in bodily lumens, for example an atrium

A device positionable in a cavity of a bodily organ (e.g., a heart) may discriminate between fluid (e.g., blood) and non-fluid tissue (e.g., wail of heart) to provide information or a mapping indicative of a position and/or orientation of the device in the cavity. Discrimination may be based on flow, or some other characteristic, for example electrical permittivity or force.
Kardium Inc.

Medical device for use in bodily lumens, for example an atrium

A device positionable in a cavity of a bodily organ (e.g., a heart) may discriminate between fluid (e.g., blood) and non-fluid tissue (e.g., wall of heart) to provide information or a mapping indicative of a position and/or orientation of the device in the cavity. Discrimination may be based on flow, or some other characteristic, for example electrical permittivity or force.
Kardium Inc.

Medical device for use in bodily lumens, for example an atrium

A device positionable in a cavity of a bodily organ (e.g., a heart) may discriminate between fluid (e.g., blood) and non-fluid tissue (e.g., wall of heart) to provide information or a mapping indicative of a position and/or orientation of the device in the cavity. Discrimination may be based on flow, or some other characteristic, for example electrical permittivity or force.
Kardium Inc.

Methods and apparatuses for remodeling tissue of or adjacent to a body passage

Medical devices and methods for making and using the same are disclosed. An example method may include a method for treating a patient having congestive heart failure.
Vessix Vascular, Inc.

System and determining the fertility phase of a female

An electronic system for determining a fertility phase of a female human comprises a wearable device (1) that includes a first sensor system (101), configured to determine heart rate and heart rate variability of the female human, and a second sensor system (102), configured to determine acceleration of the female human. The electronic system further comprises a processor (13, 30), configured to detect during menstrual cycles sleep phases with resting pulse, using the heart rate variability and the acceleration, to determine a change in the resting pulse during a menstrual cycle using the heart rate, and to determine the fertility phase using a time of the change in the resting pulse.
Ava Ag

System and non-invasive measurement of pressure inside a body including intravascular blood pressure

A device system and method for the non-invasive ultrasound measurement of the intravascular blood pressure is presented, wherein the blood pressure measurements are performed by means of the registration of the distances changes between the surface of the active piezoelectric transducer radiating an ultrasound beam into the localization area of the blood vessel or the heart chamber and the surface elements of the passive ultrasound beam reflector implanted into the blood vessel or the heart chamber. The invention is applicable to any medium transparent for ultrasound waves with the need to measure pressure changes of the liquid..
Pi-harvest Holding Ag

Cuffless blood pressure measurement using handheld device

A method for determining blood pressure is disclosed. The method comprises determining a plurality of heart sounds using a microphone of a handheld device and determining a pulse wave using a camera of the handheld device.

Method and real-time non-invasive optical monitoring of decompression sickness state

Described herein is a device and system and method for the detection of naturally occurring gas bubbles in the bloodstream; in one embodiment, a wireless optical device may be placed on various parts of the body including a finger or earlobe or is coupled with the scuba mouthpiece and detects certain vital signs such as heart rate, blood oxygen saturation (spo2) and respiration rate by analyzing the photoplethysmogram (ppg) from a miniature sensor. There is also a method and apparatus for real-time non-invasive optical monitoring of actual state of decompression sickness are presented.

Ambulatory heart monitor with conductive adhesive connection to electronics module

An ambulatory monitor includes a conductive adhesive for electrically coupling a data recording module with a patient adhereable flexible patch. The ambulatory monitor includes a skin adhereable flexible patch and a data recording module that can be mounted to and demounted from the patch..
Cardiac Insight, Inc.

Automatic heart rate diagnostics

In some examples, processing circuitry of a medical device system determines, for each of a plurality of periods, a plurality of heart rates of a patient based on a cardiac electrogram signal, and identifies a first subset of the plurality of heart rates as nighttime heart rates and a second subset of the plurality of heart rates as resting heart rates. The processing circuitry determines a representative nighttime heart rate based on the first subset of the plurality of heart rates, determines a representative resting heart rate based on the second subset of the plurality of heart rates, and determines a nocturnal dip base on the representative nighttime heart rate and the representative resting heart rate.
Medtronic, Inc.

Deep learning based isocenter positioning and fully automated cardiac mr exam planning

A computer-implemented method of performing deep learning based isocenter positioning includes acquiring a plurality of slabs covering an anatomical area of interest that comprises a patient's heart. For each slab, one or more deep learning models are used to determine a likelihood score for the slab indicating a probability that the slab includes at least a portion of the patient's heart.
Siemens Healthcare Gmbh

Introduced to electromedical equipment for automated triage of newborn with possible congenital heart defects

The present patent refers to improvements introduced in electromedical equipment, applied to automated triage of newborn babies with purpose to detect possible congenital heart defects by means of little heart test, through dedicated software (ds) implanted in memory (1-g), georeference block (1-m), pendrive (3), external hd (4), energy and supply assembly (e) provided with dc02215v j4 connector, cable and power supply, plug (p) positioned at the rear panel of the apparatus (1), internal and external connections (c) with magnets arranged into two rows at the rear part of the apparatus (1), of “c”-shape metallic base (2) with two front flanges (2-a), aiming to increase the number of users, increase flexibility of test protocol and change the usability in order to minimize errors, bringing advantages of higher testing speed, improved interface with user, better measurement quality, lower cost, higher usage versatility, and lighter weight and smaller size of equipment.. .
Hi Technologies Sa

Koninklijke Philips N.v.

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Lockstep networking

Exemplary methods, apparatuses, and systems configure a recurring heartbeat for a first field device to operate in synchronization with a second field device and a base station. The first field device turns off radio power for a hibernation period.
Gthrive, Inc

Media substitution triggered by broadcast watermark

An attention marker can be transmitted to a radio receiver using an out-of-band transmission. One or more watermarks can be inserted in an over-the-air broadcast.
Iheartmedia Management Services, Inc.

Smart watch with automatic voice recording and alarm

A wearable accoutrement such as a wristwatch records noises within a wearer's vicinity, and white noises may be filtered out to output pure human voices. The voice recording feature can be activated manually or automatically during a “panic mode” as indicated by a loud noise or sudden biological changes such as an increase in heart rate or body temperature, the accoutrement can also monitor other environmental elements such as light, motion and audio and may be paired with a wireless phone such that noise from a stressful event can be sent to a remote server which processes the data.
Sony Corporation

Server control of multiple media players in a playback page

A playback page, which can include embedded media players and a user interface that functions as an internet media station tuner, can be transmitted from a web server to a web browser running on a client computer. In response to receiving a message from the playback page indicating a user-selected media station, the web server transmits a message instructing the media station to transmit a tagged media stream to one media player (a content playback instance), and transmits a browser file to an advertisement server.
Iheartmedia Management Services, Inc.

Real-time user authentication using integrated biometric sensor

A computing device includes a housing, a processor, memory, a human interface device (i.e., a keyboard or a trackpad), and a biometric sensor integrated into the housing. The biometric sensor is configured for capturing biometric data (i.e., heartbeat data or a vein scan) from one or more of hands of a user of the device while the user's fingers are interacting with the human interface device.
Google Inc.

Method for smelting saprolite ore

Provided is a smelting method whereby a reaction for reducing pellets, said pellet being formed by using a saprolite ore as a starting material, can be effectively conducted and thus an iron/nickel alloy having a nickel grade of, for example, 16% or greater can be obtained. The method comprises: a pellet production step (s1) for producing the pellets from the saprolite ore; and a reduction step (s2) for heating and reducing the obtained pellets in a smelting furnace.
Sumitomo Metal Mining Co., Ltd.

Lid-closing device with rocker

A lid-closing device has a rototranslating pin stressed by a spring, mounted in a box and having a head adapted to hook a hook of a lid, and a rocker pivoted in the box and connected to the rototranslating pin and to a heart-shaped cam. The rocker is completely rigid and not flexible and is pivoted in the box in such manner to leave clearance in order to permit the rocker to translate so that the follower of the rocker can follow the tracks of the heart-shaped cam.
Cebi Italy S.p.a.

Pacing device with autonomous anti-tachycardia pacing

In an example, an apparatus is described that includes an implantable housing, a heart signal sensing circuit configured to sense intrinsic electrical heart signals, a ventricular tachyarrhythmia (vt) detector circuit, operatively coupled to the heart signal sensing circuit, the detector circuit operable to detect a vt based on the sensed heart signals, a processor configured to control delivery of an anti-tachyarrhythmia pacing (atp) therapy based on the detected vt, and an energy delivery circuit configured to deliver the atp therapy in response to the detected vt, wherein the apparatus does not include a shock circuit capable of delivering a therapeutically-effective cardioverting or defibrillating shock.. .
Cardiac Pacemakers, Inc.

Injectable subcutaneous string heart device

A method for subcutaneously implanting a heart device in a patient using an implantation device involves making a first incision in the vicinity of the sternum of the patient and a second incision in the lumbar region of the patient posterior to the vertebral column of the patient. The implantation device is inserted through the first incision to the second incision, and a guidewire is placed through the implantation device via the second incision to the first incision.
Newpace Ltd.

Vagus nerve and carotid baroreceptor stimulation system

Systems and methods are provided for delivering vagus nerve stimulation and carotid baroreceptor stimulation to patients for treating chronic heart failure and hypertension. The vagus nerve stimulation and carotid baroreceptor stimulation therapies may be provided using a single implantable pulse generator, which can coordinate delivery of the therapies..
Cyberonics, Inc.

Systems and methods for improving heart-rate variability

The present invention discloses neuro-stimulation systems and methods for affecting cardiovascular function, particularly for improving heart rate variability and treating arrhythmia.. .
Ziv Healthcare Ltd

Sleep apnea bi-level positive airway pressure machine with advanced diagnostics and self-cleaning capabilities

A new continuous/bi-level positive airway pressure device (c/bipap) is operable which includes both a device with a bi-directional mode of operation in a housing and a user mask to deliver air and oxygen flows and direct exhaled air to a control device. A control system receives inputs for oxygen, carbon monoxide, heart rate and air flow, both inhaled and exhale pressure and varies the input of air and oxygen and adjust the negative pressure in response to those readings.

Suction detection methods and devices

A method of detecting a suction condition during operation of a rotary blood pump with an inlet connected to a ventricle of the heart of a patient, an outlet connected to an artery of the patient, a rotor, and a control circuit configured maintain the rotor at a set rotational speed. The method includes measuring the rotational speed of the rotor at a plurality of times during each of a plurality of speed measurement intervals.
Heartware, Inc.

Heart rate determination based on vad current waveform

The present disclosure provides for methods and systems for determining heart rate of a patient. Based on motor current signals of a ventricular assist device (vad), each of first, second and third events in the measured current signal may be detected, the first event being indicative of a rise or fall in the current signal, the second event being indicative of a rise or fall in the current signal in the opposite direction as the first event, and the third event being indicative of a rise or fall in the current signal in the same direction as the first event.
Heartware, Inc.

Biological valve for venous insufficiency

A bioprosthetic valve for repairing a deep venous insufficiency in a subject includes a single leaflet from a xenogeneic heart valve attached at natural margins of attachment to a patch of valve wall tissue. The patch may extend axially above and below the leaflet and circumferentially on either side of the leaflet to provide a region for attaching the patch to a fenestration in a host vein.
Hancock Jaffe Laboratories, Inc.

Methods for detecting cardiac damage

The present mention relates to a method for detecting heart damage in a patient. The invention also relates to methods for treatment of patients identified as having heart damage.
Acorda Therapeutics, Inc.

Treatment of cardiac remodeling and other heart conditions

The present disclosure provides novel methods for treating cardiac remodeling and heart conditions using specific compounds, as well as compositions, and pharmaceutical formulations. In some embodiments, the compounds may inhibit acetylation of mef2 transcription factors..
University Of Miami

Use of biocompatible microdroplets for the treatment of atherosclerosis, heart disease and stroke

A pharmacologically acceptable emulsion of biocompatible solvent microdroplets is provided for treating atherosclerosis, heart disease and stroke. Intravenous administration of the biocompatible solvent microdroplets enables the microdroplets to bind and dissolve free cholesterol, cholesterol esters or other fatty compounds within the plaque.

Self-adjusting attachment structure for a cardiac support device

A cardiac support device includes a jacket and elastic attachment structure for self-securing the jacket to a heart. The attachment structures can include undulating metal and polymer elements, a silicone band and elastomeric filaments on a base end of the jacket..
Mardil, Inc.

Apparatus and methods for delivery, repositioning, and retrieval of transcatheter prosthetic valves

Apparatus and methods are described herein for use in the delivery and deployment of a prosthetic mitral valve into a heart. In some embodiments, an apparatus includes a catheter assembly, a valve holding tube and a handle assembly.
Tendyne Holdings, Inc.

Retaining mechanisms for prosthetic valves

Prosthetic valve systems for replacing a native valve exhibiting regurgitation comprises a support structure and a transcatheter heart valve (thv) that is separate from the support structure. The support structure can be configured to be positioned such that it extends annularly around the native valve leaflets.
Edwards Lifesciences Corporation

Techniques for securing prosthetic valves using helical anchors

A distal portion of a catheter is transluminally advanced to a heart of a subject. Via an atrium of the heart, a ventricular anchor-helix is transluminally advanced out of the distal portion of the catheter to a ventricular site in a ventricle of the heart.
Mitraltech Ltd.

Prosthetic heart valve

A prosthetic heart valve can include a radially collapsible and expandable annular frame having a plurality of struts defining openings. The prosthetic heart valve can further include a plurality of leaflets that regulate the flow of blood through the frame.
Edwards Lifesciences Corporation

Retaining mechanisms for prosthetic valves

Disclosed herein are representative embodiments of methods, apparatus, and systems used to deliver a prosthetic heart valve to a deficient valve. In one embodiment, for instance, a support member is positioned to at least partially surround the native leaflets of a valve.
Edwards Lifesciences Corporation

Apparatuses and methods for cutting a tissue bridge and/or removing a heart valve clip or suture

Disclosed is an instrument having an elongated shaft, a first member configured in the elongated shaft such that the first member can be deployed from a first portion of the instrument. The first member, when deployed, is configured over a tissue bridge within a heart, the tissue bridge having a clip or suture.
Mitracore Technologies Inc.

Electronic acoustic stethoscope with ecg

A noninvasive system for detecting and processing pcg and ecg waveforms includes an electronic acoustic stethoscope and a server computer. Heart sounds of a patient are measured using an acoustic transducer of a chestpiece of the electronic acoustic stethoscope, the heart sounds are sent to an earpiece of the electronic acoustic stethoscope, and a pcg waveform is created.

Early allergy detection, notification and management systems and methods

A watch-like early allergy detection, notification and management system is equipped with a motion detector as well as one or more physiological sensors to measure heart rate, skin color change, skin galvanic response, oxygen saturation and blood pressure to detect early symptoms of an allergic reaction. False alarms are reduced by simultaneously measuring ambient temperature and physical activity of the subject.

Drowsiness detection program medium, drowsiness detection method, and drowsiness detection apparatus

A drowsiness detection method that causes a computer to execute a process, the process includes: performing frequency analysis on heartbeat data obtained from a subject; and determining a state of the subject by calculating entropy in a predetermined frequency bandwidth with a peak as a reference, where the peak is within a predetermined frequency range of frequency distribution obtained from the frequency analysis result, determining that the subject is in a relaxation state in a case where the calculated entropy is less than a predetermined threshold value, and determining that the subject is in a drowsiness state in a case where the entropy is equal to or greater than the threshold value.. .
Fujitsu Limited

Device for detecting heart rate and heart rate variability

One or more sensors and/or sensing techniques are used individually or in combination to detect and/or measure heart rate and/or heart rate variability. The sensors may be wearable and/or portable and may operate on different principles and may include different power profiles.
Koninklijke Philips N.v.

Device and estimating the heart rate during motion

A processing unit which is adapted to measure a signal quality of the heart rate signal, to calculate the heart rate based on the heart rate signal if said signal quality is above a predefined threshold, and to estimate the heart rate based on the motion signal if said signal quality is below said threshold.. .

File transmission method, apparatus, and distributed cluster file system

A file transmission method includes: obtaining file information of a to-be-transmitted file from a distributed coordination node cluster; determining that at least one slave push node stores the to-be-transmitted file according to the file information of the to-be-transmitted file and heartbeat information of the at least one slave push node; wherein the heartbeat information of the at least one slave push node contains file information stored in the at least one slave push node, and the to-be-transmitted file is retrieved by the at least one slave push node from a file storage node cluster; generating a file transmission path, wherein the file transmission path comprises at least one destination node cluster; sending the file transmission path to the at least one slave push node, so that the at least one slave push node sends the to-be-transmitted file to the at least one destination node cluster through the file transmission path.. .
Tencent Technology (shenzhen) Company Limited

Media asset distribution with prioritization

Media delivery subsystems can deliver media files, received from a media distribution device, to end users. The media distribution device can determine a current order of distribution, specifying an order in which the media distribution device currently intends to transmit the media files, and transmit a preview message indicating the current order of distribution.
Iheartmedia Management Services, Inc.

Monitoring of replicated data instances

Replicated instances in a distributed computing environment provide for automatic failover and recovery. A component monitors the status of event processors in a set or bucket and handles the failure of an event processor.
Amazon Technologies, Inc.

System and melting light gauge metal stock

An exemplary furnace system for melting stock metal includes a main hearth and a side well subsystem, which includes a melting well disposed downstream of the main hearth for receiving flow from the main hearth, an input flow inducer disposed upstream of the melting well and downstream of the main hearth, and an output flow inducer disposed downstream of the melting well and upstream of the main hearth. The input flow inducer drives molten metal into the melting well, thereby forming a differential metal head in the melting well.
Altek Europe Ltd

Accurate cardiac event detection in an implantable cardiac stimulus device

Signal analysis in an implanted cardiac monitoring and treatment device such as an implantable cardioverter defibrillator. In some examples, detected events are analyzed to identify changes in detected event amplitudes.
Cameron Health, Inc.

Leadless medical system for quantifying ventricle to ventricle dyssynchrony

A medical system includes two or more leadless implantable medical devices, each implanted in a different ventricle of the heart and each including a housing, a first electrode secured relative to the housing, a second electrode secured relative to the housing, and a pressure sensor secured relative to the housing. Each of the leadless implantable medical devices may further include circuitry in the housing operatively coupled to the corresponding first electrode, second electrode, and pressure sensor.
Cardiac Pacemakers, Inc.

Leadless cardiac pacemaker for generating cardiac pressure volume loop

A leadless cardiac pacemaker (lcp) configured to sense cardiac activity and to pace a patient's heart. The lcp may include a housing, a first electrode secured relative to the housing, a second electrode secured relative to the housing, and a pressure sensor secured relative to the housing and coupled to the environment outside of the housing.
Cardiac Pacemakers, Inc.

Method and system for determining a cardiac cycle pace time in accordance with metabolic demand in a leadless cardiac pacemaker system

A leadless cardiac pacemaker (lcp) is configured to sense cardiac activity and to pace a patient's heart and is disposable within a ventricle of the patient's heart. The lcp may include a housing, a first electrode and a second electrode that are secured relative to the housing and are spaced apart.
Cardiac Pacemakers, Inc.

Method and system for utilizing an atrial contraction timing fiducial in a leadless cardiac pacemaker system

A leadless cardiac pacemaker (lcp) is configured to sense cardiac activity and to pace a patient's heart and is disposable within a ventricle of the patient's heart. The lcp may include a housing, a first electrode and a second electrode that are secured relative to the housing and are spaced apart.
Cardiac Pacemakers, Inc.

Cardiac volume sensing via an implantable medical device in support of cardiac resynchronization therapy

An implantable medical device (imd) configured to be implantable in a ventricle of a patient's heart may include a housing, a first electrode secured relative to the housing, a second electrode secured relative to the housing, the second electrode spaced from the first electrode, and circuitry in the housing operatively coupled to the first electrode and the second electrode. The circuitry may be configured to identify a measure of impedance between the first electrode and the second electrode at each of a plurality of times during a cardiac cycle.
Cardiac Pacemakers, Inc.

Method and system for determining pace timing in a leadless cardiac pacemaker system

A leadless cardiac pacemaker (lcp) is configured to sense cardiac activity and to pace a patient's heart and is disposable within a ventricle of the patient's heart. The lcp may include a housing, a first electrode and a second electrode that are secured relative to the housing and are spaced apart.
Cardiac Pacemakers, Inc.

Ventricular assist devices and integrated sensors thereof

A ventricular assist device for intraventricular placement inside a heart of a m