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Glycosaminoglycan

Glycosaminoglycan-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Glycosaminoglycan compositions and methods for treating connective tissue damage
Arthrodynamic Holdings, Llc
August 09, 2018 - N°20180221413

A pharmaceutical preparation and method for treating connective tissue damage in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of a glycosaminoglycan composition comprising chondroitin sulfate, hyaluronan, and n-acetyl d-glucosamine, wherein the connective tissue is skin.. .
Ophthalmic formulations comprising cooperative complexes of low- and high-molecular-weight hyaluronic acid
Altergon S.a.
August 09, 2018 - N°20180221404

Disclosed are ophthalmic formulations which use complexes called l/h-ha, obtainable by subjecting at least two fractions of hyaluronic acids and/or other glycosaminoglycans with different molecular weights to an appropriate heat cycle.. .
Treatment of cognitive impairment of mucopolysaccharidosis type iiia by intrathecal delivery of heparan n-sulfatase
Shire Human Genetic Therapies, Inc.
July 26, 2018 - N°20180207242

The present invention provides, among other things, effective treatment for sanfilippo syndrome type a (mps iiia) based on intrathecal delivery of recombinant heparan n-sulfatase (hns) enzyme. The present invention also includes methods of treating sanfilippo syndrome type a (mps iiia) syndrome by intrathecal administration of a recombinant hns enzyme at a therapeutically effective dose and an administration interval for a ...
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Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
Halozyme, Inc.
July 05, 2018 - N°20180185506

The invention relates to the discovery of novel soluble neutral active hyaluronidase glycoproteins (shasegps), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active shasegp domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain.
Method of making a hydrolyzed collagen gel
June 28, 2018 - N°20180179249

The method of making a hydrolyzed collagen gel is a manufacturing method for producing a hydrolyzed collagen gel to be used as a topical wound treatment. A first volume of purified water is initially heated to a temperature ranging from about 71° c.
Methods of making and using polyphenols complexed with a protein, peptide, amino acid, polysaccaride, disaccharide, ...
May 24, 2018 - N°20180140709

The present invention a polyphenol complexes with amino acids, peptides, proteins, glycosaminoglycans, polysaccharides, mucopolysaccharide, disaccharides, monosaccharides, amino sugars, glycol-proteins, dna/rna oligonucleotides, mrna, sirna, antibodiesor other micro- or macro biomolecules.. .
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Supramolecular glycosaminoglycans
Northwestern University
May 10, 2018 - N°20180125924

Provided herein are glycosylated peptide amphiphiles (gpas), supramolecular glyconanostructures assembled therefrom, and methods of use thereof. In particular, provided herein are glycosaminoglycan (gag) mimetic peptide amphiphiles (pas) and supramolecular gag mimetic nanostructures assembled therefrom that mimic the biological activities of gags, such as heparin, heparan sulfate, hyaluronic acid etc..
Glycosaminoglycan esters, processes for their preparation and their use in formulations for ophthalmic use
Hyalblue S.r.l.
May 03, 2018 - N°20180117077

Glycosaminoglycan esters, wherein at least part of the hydroxyl groups present on the n-acetylglucosamine residue are esterified with an apocarotenoid, their preparation, and their use in formulations for ophthalmic use are described.. .
Methods and kits for assaying endoglycosidase activity
Bio-techne Corporation
April 05, 2018 - N°20180095084

A method for assaying endoglycosidase activity includes providing a proteoglycan having a glycosaminoglycan chain with a non-reducing end; treating the proteoglycan with a glycosyltransferase to incorporate a carbohydrate into the non-reducing end of the glycosaminoglycan chain, wherein the carbohydrate includes a click chemistry moiety; adding a label to the proteoglycan, wherein the label includes a click chemistry moiety that reacts ...
Method for sulfating glycosaminoglycan
Seikagaku Corporation
March 29, 2018 - N°20180086853

An object of the present invention is provide a method for sulfating a glycosaminoglycan in a solution of a non-organic solvent. In the present invention, sulfation reaction of a glycosaminoglycan is performed with a sulfating agent in a strongly basic solution of a non-organic solvent.
Detection of oligosaccharides
Biomarin Pharmaceutical Inc.
March 22, 2018 - N°20180080059

Provided herein are processes for detecting oligosaccharides in a biological sample. In specific instances, the biological sample is provided from an individual suffering from a disorder associated with abnormal glycosaminoglycan accumulation..
Method and composition for treating cystitis
Nanologix Research, Inc.
March 15, 2018 - N°20180071216

A medicament for treating cystitis and a method of treatment are provided. An agent to repair the damaged glycosaminoglycan (“gag”) layers lining the urothelium, noted in cystitis, such as pentosan polysulfate, hyaluronic acid, chondroitin, etc., is provided in a liposomal carrier.
Glycosaminoglycan-coated metallic nanoparticles and uses thereof
Lancaster University Business Enterprises Ltd.
February 22, 2018 - N°20180049992

The present invention is a composition comprising a plurality of nanoparticles of at least one noble metal each coated with a plurality of linker molecules, at least some of which are attached to at least one of a plurality of glycosaminoglycan chains.. .
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Methods and compositions for intrathecally administered treatment of mucupolysaccharidosis type iiia
Shire Human Genetic Therapies, Inc.
February 08, 2018 - N°20180036386

The present invention provides, among other things, effective treatment for sanfilippo syndrome type a (mps ida) based on intrathecal delivery of recombinant heparin n-sulfatase (hns) enzyme. In some embodiments, the present invention includes methods of treating sanfilippo syndrome type a (mps ma) syndrome by intrathecal administration of a recombinant hns enzyme at a therapeutically effective dose and an administration interval ...
Multi-step connective tissue stabilization method and stabilized tissue formed thereby
Clemson Unviersity
February 08, 2018 - N°20180036261

A multi-step stabilization method for connective tissue is described. Stabilized tissues can exhibit increased resistance to degradation due to enzyme activity, fatigue and storage.
Cartilage compositions and methods for modifying proteoglycan content
Isto Technologies, Inc.
December 21, 2017 - N°20170360989

The present disclosure relates to cartilage repair compositions and methods for modifying the proteoglycan content of the compositions. Specifically, the methods relate to serum free, collagen free neocartilage made from chondrocytes that can be used for implants.
Glycosaminoglycan-based materials as an engineered biocompatible cellular matrix
Purdue Research Foundation
December 14, 2017 - N°20170354758

Disclosed herein is a cross-linked polymeric system comprising thiolated hyaluronic acid (ha), thiolated chondroitin sulfate (cs), and functionalized polyethylene glycol (peg), wherein said functionalized peg cross-links thiolated ha and thiolated cs. Methods of fabrication and utilization of the same are also claimed.
Determination of glycosaminoglycan levels by mass spectrometry
Shire Human Genetic Therapies, Inc.
December 07, 2017 - N°20170350900

Detecting glycosaminoglycans (gags) and/or determining the level of one or more glycosaminoglycans can be useful, e.g., in identifying or monitoring various medical conditions, the status of patients having various medical conditions, and/or the response to treatment of individuals having various medical conditions. The present invention provides methods for detecting glycosaminoglycans and/or determining the level of glycosaminoglycans ...
Method for manufacturing fungal pharmaceutical composition
Taipei Medical University
November 30, 2017 - N°20170342170

The present invention provides a method for manufacturing fungal pharmaceutical composition, used for extracting a glycosaminoglycan fiber from a fungal cell wall. Differing from the glycosaminoglycan fiber produced by using a fabrication method proposed by taiwan patent no.
Peptide and complex of same, scaffold for tissue repair and surface treatment method for same, ...
Jms Co., Ltd.
November 16, 2017 - N°20170327539

A peptide that enables surface treatment of a scaffold for tissue repair that makes it possible to accelerate the repair of living tissue without using a material that negatively affects the repair of living tissue, a complex containing this peptide, a scaffold for tissue repair surface treated using this peptide or this complex, a surface treatment method for a scaffold ...
Pharmaceutical extracts and uses thereof
November 02, 2017 - N°20170312305

The invention provides an isolated extract comprising glycosaminoglycans from whelk and/or cockle species.. .
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