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Gene-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Stable heterodimeric antibody design with mutations in the fc domain
Zymeworks Inc.
July 12, 2018 - N°20180194860

The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g. Ch2 and ch3) to accomplish selectivity between the various fc receptors involved in modulating effector function, beyond those achievable with a natural homodimeric (symmetric) fc molecule, and increased stability and purity of the resulting variant fc heterodimers.
Endoglin antibodies
Tracon Pharmaceuticals, Inc.
July 12, 2018 - N°20180194854

The present application relates to compositions of humanized and humanized/deimmunized anti-endoglin antibodies and antigen-binding fragments thereof. One aspect relates to antibodies having one or more modifications in at least one amino acid residue of at least one of the framework regions of the variable heavy chain, the variable light chain or both.
Methods for tumor treatment using cd3xcd20 bispecific antibody
Regeneron Pharmaceuticals, Inc.
July 12, 2018 - N°20180194841

The present invention relates to a method (dosage regimen) for administering a cd3×cd20 bispecific antibody to a human patient, comprising (a) administering a first dose of said antibody in a specific dosage; and consecutively (b) administering a second dose of said antibody after a period of time, wherein said second dose exceeds said first dose. The methods of ...
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Disruption of the interaction between amyloid beta peptide and dietary lipids
The Trustees Of Columbia University In The City Of New York
July 12, 2018 - N°20180194822

The present invention relates to methods of treating neurodegenerative disorders associated with alzheimer's disease (ad), parkinson's disease (pd) and synucleinopathies, such as dementia with lewy bodies, down syndrome (ds) and associated cognitive disorders, multiple system atrophy, and rare neuroaxonal dystrophies, such as niemann-pick type c disease (npc) and gaucher's disease comprising administering an inhibitor to disrupt the interaction between a&#...
Novel binding proteins based on di-ubiquitin muteins and methods for generation
Navigo Proteins Gmbh
July 12, 2018 - N°20180194819

The present invention refers to new binding proteins based on di-ubiquitin modified in 12, 13, or 14 positions selected from positions r42, i44, h68, v70, r72, l73, r74, k82, l84, q138, k139, e140, s141, and t142 of di-ubiquitin and being able to bind specifically with high affinity to selected targets. Furthermore, the invention provides a method for the generation of said binding proteins.
Method for reconstructing aspergillus niger to increase citrate production
Jiangsu Guoxin Union Energy Co Ltd
July 12, 2018 - N°20180194814

The invention discloses a method for increasing citrate production from genome reconstructed aspergillus niger. The method is to insert a gene of low affinity glucose transporter, lgt1, to genome of a.
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Use of pentapeptide-3 kttks or hexapeptide-3 kttksf for treating degenerative joint disease
Advanced Healthtech Biopeptide Laboratories Co., Ltd.
July 12, 2018 - N°20180194805

Use of pentapeptide-3 kttks or hexapeptide-3 kttksf for treating degenerative joint disease is disclosed. A pharmaceutical composition comprising an effective amount of pentapeptide-3 kttks or hexapeptide-3 kttksf and a pharmaceutically acceptable carrier is also disclosed..
Substituted 4-phenyl-pyridines
Helsinn Healthcare Sa
July 12, 2018 - N°20180194788

Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (nk1) receptor. The compounds have the general formula (i):.
Use of amine carboxyboranes as therapeutic delivery of carbon monoxide and as general drug delivery ...
University Of Alaksa Anchorage
July 12, 2018 - N°20180194784

Disclosed is a method of delivering therapeutic carbon monoxide to the cells and tissues of a patient which comprises administering thereto a compound of the formula xby1y2c(o)v (i) or pharmaceutically acceptable salts thereof. In addition, disclosed is a method of delivering a drug to a diseased cell or tissue by administering a compound of formula i ...
Bicyclic alkyne derivatives and uses thereof
Agency For Science, Technology And Research
July 12, 2018 - N°20180194771

The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazpyrimidine compounds) that act as inhibitors of the map kinase interacting kinases mnk2a, mnk2b, mnk1a, and mnk1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the prevention and treatment of diseases (e....
Third generation taxoids and methods of using same
July 12, 2018 - N°20180194744

Wherein: r1 represents a methyl group or a fluorine; r2 represents an alkyl or alkenyl group having one to six carbon atoms; or a cycloalkyl or cycloalkenyl group having three to seven ring carbon atoms; r3 represents an alkyl, alkenyl, dialkylamino, alkylamino, or alkoxy group having one to six carbon atoms; a cycloalkyl or cycloalkenyl group having three to seven ...
Compositions and methods of treating retinal disease
Aldeyra Therapeutics, Inc.
July 12, 2018 - N°20180194733

Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of a2e and/or lipofuscin, and, more specifically, for preventing the formation and/or accumulation of a2e are disclosed. .
18f - tagged inhibitors of prostate specific membrane antigen (psma) and their use as imaging ...
Ruprecht-karls-universitaet Heidelberg
July 12, 2018 - N°20180194729

The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers and imaging agents for various disease states of prostate cancer.. .
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Methods of making levulinic acid and alkyl levulinates from saccharides
Battelle Memorial Institute
July 12, 2018 - N°20180194711

Unique methods have been developed to convert polysaccharides into value-added products, such as levulinic acid and alkyl levulinates. The polysaccharides are heated in the presence of water, an alcohol, and an acid to cleave the polysaccharide, and the resulting monosacchrides or monosaccharide acetals or both are contacted with an acid in the presence of an alcohol at a higher temperature.
Method for manufacturing succinic acid
Purac Biochem B.v.
July 12, 2018 - N°20180194706

The invention pertains to a method for preparing succinic acid comprising the steps of —providing an aqueous magnesium succinate solution to an acidification step, wherein the magnesium succinate solution is acidified by the addition of hydrogen chloride, thereby obtaining an aqueous solution comprising succinic acid and magnesium chloride; —subjecting an aqueous solution comprising succinic acid and magnesium chloride ...
Production of aromatic hydrocarbons
Oh Pharmaceutical Co. Ltd
July 12, 2018 - N°20180194701

A process for producing aromatic hydrocarbons from a light alkane feedstock such as an ethane-containing hydrocarbon stream is disclosed. The process comprises: contacting a light alkane feedstock comprising at least 50% ethane with a bi-functional aromatization catalyst in a fluidized bed reactor of bubbling or turbulent fluidization regime.
Indoor food waste fermentation and recycling process
Industrial Organic Pbc
July 12, 2018 - N°20180194698

A process for fermenting and recycling food waste that is fully enclosed, eliminating noxious odors, and therefore installable in a wide variety of urban settings at scale. Generally the steps of the process include intake, shredding and grinding, inoculation and acceleration, heterolactic fermentation, separation of solids and liquids, drying and distillation, and post-processing of liquid and solid byproducts.
Microbial soil enhancements
July 12, 2018 - N°20180194697

A method enhances soil by preparing a microbial solution with microbes, a growth medium, and water; iteratively and selectively breeding generations of microbes to arrive at a predetermined microbial solution in a concentrated form of at least 1×107 cfu/ml (colony-forming units per milliliter); and storing the microbial solution in a container for enriching the soil with micronutrients, microbial cultures ...
Melt infiltration with siga and/or siin alloys
General Electric Company
July 12, 2018 - N°20180194689

Methods for forming a ceramic matrix composite (cmc) are generally provided. The method may include melt infiltrating a silicon mixture into a ceramic matrix composite preform, with the silicon mixture including siga, siin, or a mixture thereof.
Transparent rare earth aluminum garnet ceramics
Konoshima Chemical Co., Ltd.
July 12, 2018 - N°20180194685

Provided is a transparent rare earth aluminum garnet ceramic that has a high light transmission rate and can be mass produced. The transparent rare earth aluminum garnet ceramic is represented by general formula r3al5o12 (r is an element selected from the group consisting of rare earth elements having an atomic number of 65 to 71) and comprises si and y ...
Process for producing cement using a secondary fuel
Subcoal International B.v.
July 12, 2018 - N°20180194681

The invention provides a process for producing cement, the process comprising providing heat to a cement manufacturing process using a secondary fuel, wherein the secondary fuel comprises cellulose and plastic and is in the form of pellets of a size between about 3-25 mm thickness, having a calorific value of about 16 gj/ton or more, and wherein said secondary fuel ...
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