Follow us on Twitter
twitter icon@FreshPatents


Endometrial patents

      

This page is updated frequently with new Endometrial-related patent applications.

Conjugated biological molecules, pharmaceutical compositions and methods
Antibody drug conjugates (adc's) comprising a drug conjugated to antibody or antigen binding fragments thereof that bind to globo series antigen disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics.
Obi Pharma, Inc.


Septin proteins as novel biomarkers for detection and treatment of mÜllerian cancers
Provided herein, inter alia, are septin family proteins as novel biomarkers for the detection of müllerian cancers such as ovarian, fallopian tube, primary peritoneal, endometrial and uterine cancers as well as therapeutics targeting of septin-2 and other septin family genes and proteins via small molecule, antisense or antibody targeted treatment for treatment of the same. Thus, provided herein are molecular tools and methods for diagnosing müllerian cancers and for identifying subjects with an increased likelihood of having müllerian cancers..
University Of Rochester


Use of he4 and other biochemical markers for assessment of endometrial and uterine cancers
The disclosure relates to use of the he4/he4a marker(s) to assess endometrial and uterine cancer in a patient. The disclosure also relates to using tumors marks for diagnosis, grading and staging of endometrial and uterine cancers.
Fujirebio America, Inc.


B1sp fusion protein therapeutics, methods, and uses
Provided are methods, uses and pharmaceutical compositions for treatment of cancer with a b1sp fusion protein in a biologically effective amount sufficient to cause cell death of a prostate cancer cell or to inhibit proliferation of the prostate cancer cells. The cancer may be prostate cancer, breast cancer, ovarian cancer, bladder cancer, kidney cancer, glioblastoma or endometrial cancer.
The University Of British Columbia


Organic compositions to treat kras-related diseases
The present disclosure relates to rnai agents useful in methods of treating kras-related diseases such as a proliferative disease, including without limitation a solid or liquid cancer, adenocarcinoma, colorectal cancer, advanced and/or metastatic colorectal cancer, colon cancer, lung, non-small cell lung cancer and lung adenocarcinoma, acute myelogenous lung, bladder, brain, breast, cervical, endometrial, gastric, head and neck, kidney, leukemia, myelodysplastic syndrome, myeloid leukemia, liver, melanoma, ovarian, pancreatic, prostate, testicular, thyroid cancers, and cardio-facio-cutaneous (cfc) syndrome and noonan syndrome, and similar and related diseases, using a therapeutically effective amount of a rnai agent to kras.. .
Arrowhead Pharmaceuticals, Inc.


Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells
Described herein are compositions and methods of use of anti-trop-2 antibodies or antigen-binding fragment thereof to isolate, enrich, detect, diagnose and/or characterize circulating tumor cells (ctcs) from patients with a trop-2 positive cancer. Preferably, the antibody is an rs7, 162-46.2 or mab650 antibody.
Immunomedics, Inc.


Improved contraceptive methods and compositions and devices for use therein
The invention pertains to improved contraceptive methods based on a reversible pseudo state of the asherman's syndrome, in which the female body follows the normal natural part of the menstrual cycle that occurs in the ovary, the ovulatory cycle, and as a consequence the emotional life follows the normal mental passion patterns, but in which the normal uterine cycle and endometrium functions have been effectively switched off and the uterus resides in a quiescent phase preventing pregnancy and menstruation. The invention can also be used for preventing or suppressing abnormal endometrial bleeding..
Cadens Beheer B.v.


New pharmaceutical use and pharmaceutical composition of pyrroloquinoline quinine, its derivatives and/or its salts
The present invention relates to the use of pyrroloquinoline quinine (pqq), its derivatives and/or salts for the preparation of drugs for the treatment and/or prevention of endometriosis including adenomyosis, chocolate cyst of ovary, deeply infiltrating endometriosis and other type of endometriosis. In addition, the present invention relates to the use of pqq in combination with one or more the following antioxidants: n-acetyl-l-cysteine (nac), resveratrol, epigallocatechin gallate, vitamin e or vitamin c for the preparation of drugs for inhibiting the proliferation, oxidative stress status, invasion and migration of endometrial stromal cell.
Nanjing Shupeng Lifescience Co.,ltd


Method and hysteroscopy and endometrial biopsy
Methods and devices are described for performing a combined hysteroscopy and endometrial sampling. Techniques for improving visual images include forward facing fluid ports for clearing tissue debris and led positioning and design.
Coopersurgical, Inc.


Scaffolds for uterine cell growth
A method for growing polarized endometrial cells, said method comprising: (a) disposing endometrial cells on a scaffold, said scaffold comprising a silica-based glass composition, characterized by multi-modal porosity, said scaffold being to define a top side and a bottom side; (b) providing nutrients to said top and bottom sides of said scaffold and an environment to grow polarized endometrial cells on said scaffold.. .
Lehigh University


Compositions and methods for determining endometrial cancer prognosis

The present invention provides methods and compositions for determining prognosis in individual with cancer, in particular endometrial cancer. The present invention also provides methods of developing and using predictive models that are useful for determining prognosis of endometrial cancer and other similar diseases.
Quest Diagnostics Investments Llc

Methods for treating cancer with rorgamma inhibitors

The present invention provides compositions, methods, and kits comprising one or more rorγ inhibitors, alone or in combination with one or more anticancer drugs, such as an anti-androgen drug, that are useful for treating cancer, e.g., prostate cancer, such as castration-resistant prostate cancer (crpc), and numerous other types of cancer including lung cancer, breast cancer, liver cancer, ovarian cancer, endometrial cancer, bladder cancer, colon cancer, lymphoma, and glioma.. .
The Regents Of The University Of California

System and endometrial ablation

A wall of a uterus is ablated by expanding a structure in the uterus and applying energy across the wall of the structure into the uterine wall. An exterior surface of the structure conforms to an inner wall of the uterus, and the energy may cause vapor to collect between the wall and the structure.
Minerva Surgical, Inc.

Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines

The present invention relates to: use of a 2,3-dihydroimidazo[1,2-c]quinazoline compound, or of a pharmaceutical composition containing same, as a sole active agent, or of a combination of a) said compound or a pharmaceutical composition containing said compound and b) one or more further active agents, for the preparation of a medicament for the treatment or prophylaxis of endometrial cancer (hereinafter abbreviated to “ec”), particularly 1st line, 2nd line, relapsed, refractory, type i or type ii ec, or endometriosis; combinations of a) said compound and b) one or more further active agents; a pharmaceutical composition comprising said compound as a sole active agent for the treatment of endometrial cancer (hereinafter abbreviated to “ec”), particularly 1st line, 2nd line, relapsed, refractory, type i or type ii ec, or endometriosis; a pharmaceutical composition comprising a combination of a) said compound and b) one or more further active agents; use of biomarkers which is the loss of tumor suppressor pten or fbxw7, for predicting the sensitivity and/or resistance of a cancer patient to said compound and providing a rationale-based dosage to increase sensitivity and/or to overcome resistance; a method of determining the loss of tumor suppressor pten or fbxw7; and a method for determining perturbations in pik3ca, pik3cb, pik3cd, pik3cg, p1k3r1, pik3r2, pik3r3, pik3r4, pik3r5, fgfr1, fgfr2, fgfr3 and/or fgfr4.. .
Bayer Healthcare Pharmaceuticals Inc.

Method for the diagnosis of endometrial carcinoma

A method for the diagnosis of the endometrial carcinoma is disclosed.. .
Hosmotic Srl

Self-heating and hardening vibrating sensual stimulation devise

A medical, or fertility aid, or sensual device including: an outer cylindrical phallic shaped outer cover; a cylindrical phallic shaped liquid filled enclosed casing pocket; rechargeable vibrating/infrared/ultrasound core inserted into the outer cover, wherein the liquid filled pocket contains a ferrous metal disk which can be bent; and a sheath encasing the outer cover. One embodiment relates to a vibrating, and or infrared, and/or ultrasound, and heat emitting and self-hardening dildo fertility devise which offers a solution for women with endometrial or uterine caused infertility.

Msi-specific frameshift peptides (fsp) for prevention and treatment of cancer

Described is a vaccine for prevention and treatment of cancer characterized by microsatellite instability (msi). The vaccine contains an msi-specific frameshift peptide (fsp) generating humoral and cellular responses against tumor cells or a nucleic acid encoding said fsp.
Ruprecht-karls-universität Heidelberg

Prevention, treatment, and amelioration of radiation induced enteritis

The present invention provides a new method of ameliorating and/or treating enteritis induced by radiation therapy, alone or in combination with other therapies, for the treatment oil for example, gastrointestinal malignancies, including colorectal, appendiceal, anal, or small bowel cancers; urogenital malignancies, including prostate, bladder, testicular, or penile cancers; gynecologic malignancies, including cervical, endometrial, ovarian, vaginal, or vulvar cancers; or osteogenic and other sarcomatous malignancies in which pelvic structures are involved, comprising the administration of a therapeutically effective amount of balsalazide to a patient in need thereof. .

Method and tissue ablation

Methods of ablating endometrial tissue are disclosed. The methods include providing an ablation device that has a catheter with a hollow shaft through which an ablative agent can travel, a first positioning element, and a second positioning element positioned on the catheter distal to the first positioning element.

Method of contraception

The invention is related to an improved method of contraception, for preventing or suppressing abnormal and/or irregular endometrial bleeding and achieving a rapid induction of amenorrhea by using an intrauterine delivery system comprising controlled release levonorgestrel over a prolonged period of time and at a therapeutic level required for contraception, and a sufficient amount of nsaid capable of suppressing abnormal and/or irregular endometrial bleeding. .

Endometrial stem cells and methods of making and using same

The invention provides pluripotent stem cells and methods for making and using pluripotent stem cells. Pluripotent stem cells, among other things, can differentiate into various cell lineages in vitro, ex vivo and in vivo.
Xon Cells, Inc.

Antibodies, pharmaceutical compositions and methods

Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to stage-specific embryonic antigen 4 (ssea-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics.
Obi Pharma, Inc.

Anti-trop-2 antibody-drug conjugates and uses thereof

Described herein are compositions and methods of use of antibody-drug conjugates (adcs) comprising an anti-trop-2 antibody or antigen-binding fragment thereof, conjugated to one or more cytotoxic drugs. Preferably, the antibody is an rs7, 162-46.2 or mab650 antibody.
Immunomedics, Inc.

Usp14 as a biomarker for predicting recurrence in endometrial and ovarian cancer

Usp14 is a biomarker for recurrent disease and inhibition of usp14 is of therapeutic benefit for women with endometrial or ovarian cancer.. .
Regents Of The University Of Minnesota

Methods and materials for treating endometrial cancer

This document provides methods and materials for detecting and/or treating endometrial hyperplasia and/or endometrial cancer. For example, this document provides methods and materials for identifying a female mammal as having endometrial hyperplasia and administering a therapy (e.g., hormone therapy) to the female mammal.
Mayo Foundation For Medical Education And Research

Anti-clusterin antibodies and antigen binding fragments and their use to reduce tumor volume

Novel antibodies and antigen binding fragments that specifically bind to clusterin are described. In some embodiments, the antibodies block the biological activity of clusterin and are useful in composition in certain cancers, more particularly in cancers, such as endometrial carcinoma, breast carcinoma, hepatocellular carcinoma, prostate carcinoma, a renal cell carcinoma, ovarian carcinoma, pancreatic carcinoma, and colorectal carcinoma.
National Research Council Of Canada

Cancer therapeutics

This invention relates to compounds that bind to wild-type cbfβ and inhibit cbfβ binding to runx proteins. The potent compounds of the invention inhibit this protein-protein interaction at low micromolar concentrations, using allosteric mechanism to achieve inhibition, displace wild-type cbfβ from runx1 in cells, change occupancy of runx1 on target genes, and alter gene expression of runx1 target genes.
University Of Virginia Patent Foundation

Methods and systems for endometrial ablation utilizing radio frequency

Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an rf ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric wall capable of non-expanded and expanded shapes.
Minerva Surgical, Inc.

Endometrial ablation devices and system

Systems and methods for endometrial ablation. The systems include a handle and elongated introducer sleeve extending to an expandable working end having a fluid-tight interior chamber.
Hermes Innovations Llc

Method and tissue ablation

Methods of ablating endometrial tissue are disclosed. The methods include providing an ablation device that has a catheter with a hollow shaft through which an ablative agent can travel, a first positioning element, and a second positioning element positioned on the catheter distal to the first positioning element.

Pme-1 as a biomarker to predict and diagnose an increased risk of endometrial cancer and gene silencing of pme-1 to inhibit epithelial to mesenchymal transition

Disclosed are methods of attenuating activity of the pme-1 gene. Sirnas or shrnas are used to target against pme-1, thereby reducing the pme-1 mrna.
Medical Diagnostic Laboratories, L.l.c.

Methods and materials for treating endometrial cancer

This document provides methods and materials for treating endometrial cancer. For example, methods and materials for identifying a female mammal as having endometrial cancer and surgically removing at least the uterus of the female are provided..
Mayo Foundation For Medical Education And Research

Method for treatment of primary hormone resistant endometrial and breast cancers

The invention provides a method for treatment of primary progesterone receptor-negative (pr−) endometrial cancer comprising administering (i) cridanimod or a salt or an ester thereof and (ii) a progesterone receptor (pr) agonist. The invention further provides a method for treatment of a primary estrogen receptor-negative (er−) breast cancer, comprising administering (i) cridanimod or a salt or an ester thereof and (ii) a selective estrogen receptor modulator (serm) or a selective estrogen receptor down-regulator (serd).
Lipoxen Technologies Limited

Method for treatment of primary hormone resistant endometrial and breast cancers

The invention provides a method for treatment of primary progesterone receptor-negative (pr−) endometrial cancer comprising administering (i) cridanimod or a salt or an ester thereof and (ii) a progesterone receptor (pr) agonist. The invention further provides a method for treatment of a primary estrogen receptor-negative (er−) breast cancer, comprising administering (i) cridanimod or a salt or an ester thereof and (ii) a selective estrogen receptor modulator (serm) or a selective estrogen receptor down-regulator (serd).
Lipoxen Technologies Limited

Compositions and methods for suppressing endometrial proliferation

The subject matter of the instant invention is pertinent to the field of hormone therapy. More specifically, the subject matter of the instant invention concerns methods of treating estrogen-dependent conditions such as endometrial hyperplasia and endometrial cancer in a female undergoing estrogen and/or selective estrogen receptor modulator (serm) therapy.
Repros Therapeutics Inc.

Monoclonal antibodies that specifically block biological activity of a tumor antigen

This invention relates to novel monoclonal antibodies that specifically bind to the alpha-folate receptor. In some embodiments, the antibodies inhibit a biological activity of folate receptor-α (fr-α).
Morphotek, Inc.

Human androgen receptor dna-binding doman (dbd) compounds as therapeutics and methods for their use

A compound having the structure of formula i, wherein a is a substituted or unsubstituted aryl or heteroaryl group, d is a substituted or unsubstituted 5- or 6-membered heteroaryl or heterocyclyl group and e is a substituted or unsubstituted aryl, heteroaryl, cycloalkyl or heterocyclyl group. The compounds are used for the treatment of androgen modulated indications including cancer (prostate, breast, ovarian, endometrial or blader cancer), hair loss, acne, hirsutism, ovarian cysts, polycystic ovary disease, precocious puberty and age related macular degeneration.
The University Of British Columbia

Anti-folate receptor alpha antibodies and uses thereof

Described herein are antibodies, and antigen-binding fragments thereof, that are specific for folate receptor alpha, related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits.
Eisai R&d Management Co., Ltd.

Nitrogen-containing aromatic heterocyclic compound

As a result of studies on compounds having fgfr inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on fgfr1, fgfr2, and/or fgfr3, particularly, mutant fgfr3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a therapeutic agent for various cancers related to fgfr1, fgfr2, and/or fgfr3, such as lung cancer and hormone therapy-resistant breast cancer, stomach cancer, triple negative breast cancer, endometrial cancer, bladder cancer, and glioblastoma, particularly as a prophylactic and/or therapeutic agent for mutant fgfr3-positive bladder cancer..
Kotobuki Pharmaceutical Co., Ltd.

Systems and methods for endometrial ablation

A system for treating uterine tissue having a seal assembly configured for positioning in a patient's cervical canal and uterine cavity; an expandable distal balloon portion; an expandable elongate medial balloon portion configured for movement between a first transversely expanded shape for engaging a cervical canal and a second transversely non-expanded shape for trans-cervical insertion; and a fluid source in communication with distal balloon portion and medial balloon portion for expansion of said balloon portions.. .

Stem cell therapy in endometrial pathologies

The invention generally relates to the ability of autologous cd133+ bone marrow stem cells (bmdsc) to induce endometrial regeneration and treat endometrial pathologies such as asherman's syndrome and endometrial atrophy. Methods to induce endometrial regeneration are provided, which comprises administering an effective amount of autologous cd133+ bone marrow derived stem cells (bmdsc) into uterine arteries of a subject in need thereof to induce endometrial regeneration..
Igenomix S.l.

Vagina evaluation device and uterus evaluation device

A non-invasive and accurate vagina evaluation device and uterine evaluation devices are provided that measure the receptivity (uterine implantation capacity) of the mother's body to a fertilized egg implanting itself into the uterus. A first vagina evaluation device includes: a main body stretchable and expandable after insertion into a vagina, followed by air injection thereinto; four electrodes brought into contact with the vagina wall as the main body expands and stretches; and fixation means configured to fix the interval of arrangement of the electrodes.
Osaka University

Method of treating endometriosis

The present invention is a method of treating or preventing endometriosis by means of administering stem cells to a patient. The stem cells are preferably drawn from umbilical cord tissue and/or umbilical cord blood and are preferably combined with a liquid carrier to form a stem cell solution.
Predictive Therapeutics, Llc

Bcl6 expression in eutopic endometrium as a marker for endometriosis and subfertility

Methods for identifying subjects as candidates for embryo implantation are provided. In some embodiments, the methods include providing a sample of endometrium isolated from a subject during the second half of the subject's menstrual cycle and determining whether the subject is a candidate based on the expression of bcl6 in the sample.
Greenville Health System

Compositions and methods for modulating the immune system

A novel class of embryo derived peptides are described (preimplantation factor) that were generated synthetically and were tested on peripheral blood immune cells and shown to block activated but not basal immunity, inhibiting cell proliferation and creating a th2 type cytokine bias, in addition pif enhance endometrial receptivity by increasing adhesion molecules expression. Pif biological activity appears to be exerted by specific binding to inducible receptors present on the several white cell lineages.
Bioincept, Llc

Use of eribulin and mtor inhibitors as combination therapy for the treatment of cancer

Methods for treating cancer (e.g., breast cancer, lung cancer, pancreatic cancer, primitive neuroectodermal tumors, lung cancer, ovarian cancer, endometrial cancer, pharyngeal cancer, esophageal cancer, and sarcoma) in a subject (such as an human patient) in need thereof by administering eribulin (e.g., eribulin mesylate, i.e., e7389, halaven) in combination with one or more mammalian target of rapamycin (mtor) inhibitors (e.g., everolimus, ridaforolimus, and temsirolimus), and kits therefor are provided.. .
Eisai R&d Management Co., Ltd.

Systems and methods for endometrial ablation

An endocervical seal has a sleeve with a passageway for receiving an intrauterine interventional or diagnostic tool. The sleeve has a coaxially disposed outer balloon with a distal portion configured to inflate in a cervical os and a proximal portion configured to inflate in a cervical canal..
Minerva Surgical, Inc.

Antibodies, antibody drug conjugates and methods of use

This invention relates to antibody drug conjugates (adc), antibody conjugates (ac) and novel antibodies. Particularly, the adc, ac and antibodies disclosed herein specifically bind to the human anti-müllerian hormone type ii receptor (amhr-ii) and can be used to treat and/or identify amhr-ii expressing cancers, such as prostate cancer, breast cancer and gynecologic cancers expressing amhr-ii, such as ovarian cancer, in particular metastatic ovarian cancer, serous cancer, hypernephroma, endometrioid, colloidal epithelium, prostate cancer, germ cell cancer, endometrial cancer, mixed müllerian malignant tumor of the uterus, leiomyosarcoma, or endometrial stromal sarcoma..
Gamamabs Pharma

Methods and systems for endometrial treatment

Methods of treating endometrial dysfunction are described including retrieval of endometrial cells including endometrial stem cells from a fertile donor and transplantation of endometrial cells or tissue into a host suffering from endometrial dysfunction. In certain embodiments, methods include genetic modification, tissue culturing, or cryopreservation of the endometrial cells prior to transplantation.
Celmatix Inc.

Duocarmycin adcs for use in treatment of endometrial cancer

The present invention relates to duocarmycin-containing antibody-drug conjugates (adcs) for use in the treatment of human solid tumours expressing her2, wherein the human solid tumour expressing her2 is endometrial cancer, in particular uterine serous carcinoma (usc). In particular, the present invention relates to duocarmycin-containing adcs for use in the treatment of endometrial cancer, notably usc, with her2 ihc 2− or 1+ and her2 fish negative tumour tissue status..
Yale University

Methods for detecting, diagnosing and treating endometrial cancer

The present invention relates to methods for detecting, diagnosing and/or treating endometrial cancer by detecting in a biological sample from a patient the levels of one or more of the metabolites: c14.2, pc ae c38:1, 3-hydroxybutyric acid, c18:2, pc ae c40:1, and c6 (c4:1-dc). In some embodiments, the method also includes diagnosing the patient with endometrial cancer when the one or more metabolites in the biological sample is at a different level than a statistically validated threshold for the one or more metabolites, and ultrasound indicates endometrial cancer in the patient.
William Beaumont Hospital

Therapeutic immune modulation by stem cell secreted exosomes

Disclosed are methods, compositions of matter, and protocols useful for the induction of a therapeutic immune modulatory response through administration of exosomes derived from a stem cell source. In one embodiment, said stem cell source is endometrial regenerative cells.
Xon Cells, Inc.

Device for endometrial ablation having an expandable seal for a cervical canal

Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an rf ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric wall capable of non-expanded and expanded shapes and for conforming to an asymmetric or symmetric shape of the patient's cervix.
Minerva Surgical, Inc.

Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells

Described herein are compositions and methods of use of anti-trop-2 antibodies or antigen-binding fragment thereof to isolate, enrich, detect, diagnose and/or characterize circulating tumor cells (ctcs) from patients with a trop-2 positive cancer. Preferably, the antibody is an rs7, 162-46.2 or mab650 antibody.
Immunomedics, Inc.

Detection of chromosomal abnormalities associated with endometrial cancer

The methods and compositions described herein address the need for diagnostic method that could be offered to women during yearly checkups to allow for early detection, diagnosis and classification, and treatment of endometrial cancer. In addition, these methods and compositions address the current need for improving diagnostic accuracy of biopsy procedures in symptomatic patients..
Abbott Molecular

Aryl naphthyl methanone oxime(s) and process for preparation thereof

The present invention relates to substituted aryl naphthyl methanone oximes of general formula (i), their process for preparation and their derivatives, salts, pharmaceutical composition thereof and their use in treatment of chronic myelogenous leukemia, acute myelogenous leukemia, lymphoma, multiple myeloma, solid tumor forming cell- lines including such as breast cancer, endometrial cancer colon cancer, prostate cancer and killing of drug resistant cancer stem cells, as subject in need thereof.. .
Council Of Scientific & Industrial Research

Systems and methods for endometrial ablation

A device for endometrial ablation having an elongated shaft with a working end comprising an expandable-contractable frame, a complaint energy-delivery surface carried by the frame, the surface and the frame being configured to engage against the interior of a patient's uterine cavity when the working end is inserted into the cavity and the frame is expanded.. .
Minerva Surgical, Inc.

Method of evaluating female genital cancer

According to the method of evaluating female genital cancer of the present invention, amino acid concentration data on concentration values of amino acids in blood collected from a subject to be evaluated is measured, and the state of female genital cancer including at least one of cervical cancer, endometrial cancer, and ovarian cancer in the subject is evaluated based on the concentration value of at least one of thr, ser, asn, gln, pro, gly, ala, cit, val, met, ile, leu, tyr, phe, his, trp, orn, lys, and arg contained in the measured amino acid concentration data of the subject.. .
Ajinomoto Co., Inc.

Method of treating endometrial tissue disease by altering an epithelial to mesenchymal transition

The present invention is a method of treating endometrial tissue disease and in particular a method of treating endometriosis and adenomyosis by administering an epithelial-to-mesenchymal transition altering compound. The compound may be a natural compound or a synthetic compound.

Preventing or mitigating chemotherapy induced alopecia using vitamin d

The invention provides methods and pharmaceutical compositions for preventing or mitigating chemotherapy-induced alopecia (cia). The pharmaceutical compositions of the invention comprise an effective amount of a vitamin d compound in a topical formulation.
Berg Llc

System and endometrial ablation

A wall of a uterus is ablated by expanding a structure in the uterus and applying energy across the wall of the structure into the uterine wall. An exterior surface of the structure conforms to an inner wall of the uterus, and the energy may cause vapor to collect between the wall and the structure.
Minerva Surgical, Inc.

Methods of diagnosing, classifying and treating endometrial cancer and precancer

Diagnostic and therapeutic applications for endometrial cancer are described. The diagnostic and therapeutic applications are based on certain activation mutations in the fgfr2 gene and its expression products.
Washington University

Substituted 1,2,3,4-tetrahydroisoquinoline derivatives for the treatment of hormone-dependent diseases

Provided are compounds of general formula a and a′, wherein x1 and x2 are each c, ch or n; r3 and r4 are each h, optionally substituted c1-c30 saturated or unsaturated chemical group, or together form an optionally substituted c5-c8 cycle; z1; z2 and z3 are each n or ch; v is c═o, c═s or ch2; n is from 1 to 12; w1 and w2 are each h, ch2, o or s; and r1 and r2 are each h, cr1c6 alkyl, c1c6 aryl, c1c12 alkylaryl, optionally substituted phenyl, c1c6 alkoxy, c1c6 thioalkoxy, f, cl, br or i. These compounds inhibit steroid sulfatase (sts), act as selective estrogen receptor modulators (serms), increase alkaline phosphatase (alp) activity, and are useful in the treatment of medical conditions involving hormones such as breast cancer, prostate cancer, endometriosis, osteoporosis, benign prostatic hyperplasia and endometrial cancer..
UniversitÉ Laval

Methods and systems for endometrial ablation utilizing radio frequency

Methods, systems and devices for endometrial ablation. In accordance with a method, a working end of an rf ablation device is positioned in a patient uterus to contact endometrial tissue, the working end comprising a dielectric wall capable of non-expanded and expanded shapes.
Minerva Surgical, Inc.

Endometrial sample collector

A non-invasive endometrial sample collector has an outer body of absorbent material configured for insertion into a vaginal cavity of a patient such that a distal end of the body is positioned proximate a uterine cervix of the patient. The collector has an internal collection assembly disposed within the outer body of absorbent material.
Innova-tech, Llc

Method for separation of sporadic cells from body fluids, and carrying out said method

Method for gentle separation of viable sporadic cells from body fluids such as blood, from malignant effusions, bronchoalveolar lavage fluid, peritoneal lavage fluid and amniotic fluid, based on a filter membrane which is in an intimate contact with an absorbent material. Using the present method it is possible to isolate for example circulating and disseminated tumor cells, endometrial cells and circulating trophoblast cells, allowing subsequent detection, quantification, characterization and especially culturing of said cells.
Metacell, S.r.o.

Prevention, treatment, and amelioration of radiation induced enteritis

The present invention provides a new method of ameliorating and/or treating enteritis induced by radiation therapy, alone or in combination with other therapies, for the treatment oil for example, gastrointestinal malignancies, including colorectal, appendiceal, anal, or small bowel cancers; urogenital malignancies, including prostate, bladder, testicular, or penile cancers; gynecologic malignancies, including cervical, endometrial, ovarian, vaginal, or vulvar cancers; or osteogenic and other sarcomatous malignancies in which pelvic structures are involved, comprising the administration of a therapeutically effective amount of balsalazide to a patient in need thereof. .

Endometrial lining tissue treatment device

An endometrial tissue treatment device includes an elongate positioning member and an energy applicator coupled to a distal end of the positioning member, the energy applicator including a tissue contacting member and an expandable-collapsible support structure underlying the tissue contacting member, the expandable-collapsible support structure comprising a substantially non-compliant elongate balloon disposed within the tissue contacting member that, when inflated, has a length oriented substantially transverse to the positioning member, including a first closed end that positions a corresponding first corner portion of the tissue contacting member in a first cornu of a uterine cavity, and a second closed end that positions a corresponding second corner portion of the tissue contacting member in a second cornu of a uterine cavity, with a lengthwise portion of the balloon positioning a distal facing portion of the tissue contacting member for contacting a fundal wall of a uterus.. .
Hologic, Inc.

Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds

Biomarkers are provided that predict whether a subject having endometrial cancer will or will not respond to a therapy comprising lenvatinib or a pharmaceutically acceptable salt thereof (e.g., lenvatinib mesylate). The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for and treating a subject having, suspected of having, or at risk of developing an endometrial cancer..
Eisai R&d Management Co., Ltd.

Asrgl1 in endometrial cancer

There is provided a method for determining whether a mammalian subject having an endometrial cancer belongs to a first or a second group, wherein the prognosis of subjects of the first group is better than the prognosis of subjects of the second group, comprising the steps of: a) evaluating an amount of asrgl1 in at least part of a sample earlier obtained from the subject and determining a sample value corresponding to the evaluated amount; b) comparing said sample value with a predetermined reference value; and if said sample value is higher than said reference value, c1) concluding that the subject belongs to the first group; and if said sample value is lower than or equal to said reference value, c2) concluding that the subject belongs to the second group.. .
Atlas Antibodies Ab

Ras inhibitors and uses thereof

Described herein are compounds of formulae (i)-(ii), and pharmaceutically acceptable salts, and pharmaceutical compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases such as cancers (e.g., lung cancer, large bowel cancer, pancreas cancer, biliary tract cancer, or endometrial cancer), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases in a subject..
Dana-farber Cancer Institute, Inc.

Msi-specific frameshift peptides (fsp) for prevention and treatment of cancer

Described is a vaccine for prevention and treatment of cancer characterized by microsatellite instability (msi). The vaccine contains an msi-specific frameshift peptide (fsp) generating humoral and cellular responses against tumor cells or a nucleic acid encoding said fsp.
Ruprecht-karls-universitat Heidelberg

Treatment of endometriosis, angiogenesis and/or endometrial lesion growth

Synuclein-gamma (sncg) inhibitors are useful for inhibiting or treating angiogenesis, endometriosis and/or endometrial lesion growth. They also potentiate efficacy of other hormonal agents in treating angiogenesis, endometriosis and/or endometrial lesion growth..
Syng Pharmaceuticals Inc.

Methods of diagnosing endometriosis

The present invention provides biomarkers for the diagnosis and prognosis of endometriosis. Generally, the methods of this invention find use in diagnosing or for providing a prognosis for endometriosis by detecting the expression levels of biomarkers, which are differentially expressed (up- or down-regulated) in endometrial cells from a patient with endometriosis.
The Regents Of The University Of California

Minimally invasive access channels into bodily regions

The present invention discloses access devices and methods to create an access channel for introduction of one or more working devices into an anatomical region. The access channel is created using a visualization modality that is later removed before inserting one or more working devices through the access channel.
Microcube, Llc

Duocarmycin adcs for use in treatment of endometrial cancer

The present invention relates to duocarmycin-containing antibody-drug conjugates (adcs) for use in the treatment of human solid tumours expressing her2, wherein the human solid tumour expressing her2 is endometrial cancer, in particular uterine serous carcinoma (usc). In particular, the present invention relates to duocarmycin-containing adcs for use in the treatment of endometrial cancer, notably usc, with her2 ihc 2− or 1+ and her2 fish negative tumour tissue status..
Yale University

Compositions and methods for modulating the immune system

A novel class of embryo derived peptides are described (preimplantation factor) that were generated synthetically and were tested on peripheral blood immune cells and shown to block activated but not basal immunity, inhibiting cell proliferation and creating a th2 type cytokine bias, in addition pif enhance endometrial receptivity by increasing adhesion molecules expression. Pif biological activity appears to be exerted by specific binding to inducible receptors present on the several white cell lineages.
Bioincept, Llc