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Dna Polymerase

Dna Polymerase-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Devices, systems, and methods for single molecule, real-time nucleic acid sequencing
September 13, 2018 - N°20180258472

Methods, systems, and reagents for real-time single molecule sequencing of nucleic acids, particularly long dna molecules, is described. Preferably, such methods and systems combine fret (förster resonance energy transfer)-based proximity sensing of labeled nucleotides in or near a dna polymerase's active site with fret-based monitoring of the conformational changes in the polymerase that occur during nucleotide incorporation..
Dna sequencing detection field effect transistor
International Business Machines Corporation
August 23, 2018 - N°20180237848

A semiconductor structure is provided that can be used for dna sequencing detection. The semiconductor structure includes a doped epitaxial source semiconductor material structure located on a first portion of a semiconductor substrate and a doped epitaxial drain semiconductor material structure located on a second portion of the semiconductor substrate.
Recombinant polymerases for incorporation of protein shield nucleotide analogs
Pacific Biosciences Of California, Inc.
August 09, 2018 - N°20180223352

Provided are compositions comprising recombinant dna polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing or nucleic acid amplification. Such properties include enhanced performance with large nucleotide analogs, increased stability, increased readlength, and improved detection of modified bases, and can also include resistance to photodamage, ...
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Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer ...
Nanobiosym, Inc.
July 12, 2018 - N°20180195104

The present application discloses methods and apparatuses for single molecule drug screening, discovery and validation. These methods and apparatuses allow a user to detect rapidly, using observation of single molecules, whether and how a drug candidate interferes with a target enzyme involved in a particular disease pathway.
Dna polymerases with increased 3'-mismatch discrimination
Roche Molecular Systems, Inc.
July 05, 2018 - N°20180187171

Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods.
Methods for assembling dna molecules
Synthetic Genomics, Inc.
June 14, 2018 - N°20180163254

The invention provides compositions and methods for assembling a dna molecule having a desired sequence. The methods involve contacting a dna polymerase, dntps, and a plurality of pairs of oligonucleotides.
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Polymerases engineered to reduce nucleotide-independent dna binding
Omniome, Inc.
June 07, 2018 - N°20180155698

Provided are engineered dna polymerases exhibiting modified functionality, and polynucleotides encoding same. Modified features include: (1) reduced catalytic activity in the presence of magnesium ions and/or (2) reduced affinity for primed template nucleic acid molecules in the absence of cognate nucleotide, and an ability to discriminate between cognate and non-cognate nucleotides under low salt conditions.
Dna polymerases with increased 3’-mismatch discrimination
Roche Molecular Systems, Inc.
May 24, 2018 - N°20180142221

Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods.
Dna polymerases with increased 3'-mismatch discrimination
Roche Molecular Systems, Inc.
May 24, 2018 - N°20180142220

Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods.
Pore-forming protein conjugate compositions and methods
The Trustees Of Columbia University In The City Of New York
May 17, 2018 - N°20180135121

The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore-forming protein, such as α-hemolysin, to a biomolecule, such as antibodies, receptors, and enzymes, such as dna polymerase, and the use of such pore-forming conjugates in nanopore devices and methods.. .
Dna polymerases with increased 3'-mismatch discrimination
Roche Molecular Systems, Inc.
May 17, 2018 - N°20180135034

Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods.
Dna polymerases with improved activity
Roche Molecular Systems, Inc.
May 17, 2018 - N°20180135033

Disclosed are dna polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods.
Method for detecting target nucleic acid
Ngk Insulators, Ltd.
May 03, 2018 - N°20180119211

The disclosure of the present description provides a method for detecting a target nucleic acid, whereby probe hybridization can be accomplished efficiently. To that end, a target nucleic acid is amplified using a first primer having a tag sequence complementary to a detection probe pre-associated with the target nucleic acid and a first recognition sequence that recognizes a first base ...
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Dna polymerases with increased 3'-mismatch discrimination
Roche Molecular Systems, Inc.
May 03, 2018 - N°20180119116

Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods.
Recombinant dna polymerase for improved incorporation of nucleotide analogues
Personal Genomics, Inc.
May 03, 2018 - N°20180119115

A composition comprising a recombinant dna polymerase and 3′-esterified nucleotide analogues is provided. The recombinant dna polymerase includes an amino acid sequence that is at least 90% homology with 9° n dna polymerase (seq id no: 1), and the recombinant dna polymerase includes at least two mutations at the positions corresponding to amino acid residues 141 and 143 of the 9° n dna ...
Methods and compositions for pcr
Life Technologies Coroporation
April 05, 2018 - N°20180094250

A modified thermostable pol b dna polymerase, produced by a reaction, under essentially aqueous conditions, of a thermostable pol b dna polymerase and a modifier reagent of formula i wherein the reaction results in a thermally reversible inactivation of the thermostable pol b dna polymerase activity and the 3′-5′ exonuclease activity, which polymerase is suitable for hot-start pcr. ...
Qualitative and absolute quantification kit for detecting hepatitis b virus cccdna
March 15, 2018 - N°20180073087

A composition for detecting hepatitis b virus cccdna includes an upstream primer having the dna sequence set forth in seq id no. 1, a downstream primer having the dna sequence set forth in seq id no.
Affenadenovirus (gorilla) or adenoviral vectors and methods of use
Genvec, Inc.
March 08, 2018 - N°20180066281

The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pix protein, dna polymerase protein, penton protein, hexon protein, and/or fiber protein.. .
Enzyme preparation containing thermostable dna polymerase, method for producing same, and method for detecting subject ...
National University Corporation University Of Toyama
March 01, 2018 - N°20180057860

Disclosed is a thermostable dna polymerase preparation which can illimitably reduce the risk of false positivity in the detection of a subject microorganism utilizing a gene amplification reaction and therefore enables the selective amplification of dna for detecting the subject microorganism even when the amount of the subject microorganism is small and therefore the amount of dna collected therefrom is ...
Materials and methods for the synthesis of error-minimized nucleic acid molecules
Synthetic Genomics, Inc.
February 22, 2018 - N°20180051280

The present invention provides materials and methods useful for error correction of nucleic acid molecules. In one embodiment of the invention, a first plurality of double-stranded nucleic acid molecules having a nucleotide mismatch are fragmented by exposure to a molecule having unidirectional mismatch endonuclease activity.
Dna polymerases with increased 3'-mismatch discrimination
Roche Molecular Systems, Inc.
February 15, 2018 - N°20180044648

Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods.
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