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Cytosine

Cytosine-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Cytidine-5-carboxamide modified nucleotide compositions and methods related thereto
Somalogic, Inc.
July 19, 2018 - N°20180201641

Described herein are 5-position modified cytosine nucleotides and nucleosides as well as phosphoramidites and triphosphates derivatives thereof. Further provided are methods of making and using the same, and compositions and uses of the modified nucleosides as part of a nucleic acid molecule (e.g., aptamer)..
Immunostimulating oligonucleotide complex
Denka Company Limited
July 12, 2018 - N°20180193371

Provided is an immunostimulating oligonucleotide that is suitable for industrial production and has an excellent type-i ifn inducing activity even when not modified to become a phosphorothioate. This linear double-stranded oligonucleotide contains 10-100 base pairs, wherein the single-stranded oligonucleotides constituting the double-stranded oligonucleotide each contain 2-20 phosphodiester-mediated cytosine-guanine (cpg) sequences, and at least 90% of the internucleotide bonds in each single-stranded ...
Tal-tet1 fusion proteins and methods of use thereof
The General Hospital Corporation
July 05, 2018 - N°20180187168

Fusion proteins comprising a dna binding domain, e.g., a tal effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines in dna, and methods of use thereof.. .
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Selective oxidation of 5-methylcytosine by tet-family proteins
The United States Of America, As Represented By The Secretary, Department Of Health & Human Servic
June 28, 2018 - N°20180180602

The present invention provides for novel methods for regulating and detecting the cytosine methylation status of dna. The invention is based upon identification of a novel and surprising catalytic activity for the family of tet proteins, namely tet1, tet2, tet3, and cxxc4.
Selective oxidation of 5-methylcytosine by tet-family proteins
The United States Of America, As Represented By The Secretary, Department Of Health & Human
June 28, 2018 - N°20180179587

The present invention provides for novel methods for regulating and detecting the cytosine methylation status of dna. The invention is based upon identification of a novel and surprising catalytic activity for the family of tet proteins, namely tet1, tet2, tet3, and cxxc4.
Compositions and methods for analyzing modified nucleotides
New England Biolabs, Inc.
June 21, 2018 - N°20180171397

Methods and compositions are provided for identifying any of the presence, location and phasing of methylated and/or hydroxymethylated cytosines in nucleic acids including long stretches of dna. In some embodiments, the method may comprise reacting a first portion (aliquot) of a nucleic acid sample with a dioxygenase and optionally a glucosyltransferase in a reaction mixture containing the nucleic acid ...
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Systems and methods to predict autism before onset of behavioral symptoms and/or to diagnose ...
Bioscreening & Diagnostics Llc
May 24, 2018 - N°20180142298

Systems and methods to predict or diagnose autism are described. Using markers, the systems and methods can predict or diagnose autism based on significant differences in methylation of cytosine bases in many loci throughout the genome.
Measuring a level of a 5-hydroxymethylcytosine in a sample from a subject having a cancer ...
The United States Of America, As Represented By The Secretary, Department Of Health & Human Servi
May 03, 2018 - N°20180120304

Provided herein are methods and kits for measuring a level of a 5-hydroxymethylcytosine in a nucleotide sequence from a subject, wherein the subject is a subject having a cancer or suspected of having cancer.. .
Selective oxidation of 5-methylcytosine by tet-family proteins
The United States Of America, As Represented By The Secretary, Department Of Health & Human Servi
May 03, 2018 - N°20180119113

The present invention provides for novel methods for regulating and detecting the cytosine methylation status of dna. The invention is based upon identification of a novel and surprising catalytic activity for the family of tet proteins, namely tet1, tet2, tet3, and cxxc4.
Risk stratification method for a patient having a polymorphism
Helicalhelp Llc
April 12, 2018 - N°20180100195

A risk stratification method for a patient in a disease state and specifically patients presenting a tumor, includes determining if the patient is a homozygote or heterozygote and further determining the allelic expression for the patient, cc, t/c, or c/t. For patients having the cytosine methylated, they have a t/c allelic expression and patients without a methylated ...
Recombinant vectors
Tocagen Inc.
March 29, 2018 - N°20180087035

This disclosure provides modified cytosine deaminases (cds). The disclosure further relates to cells and vector expressing or comprising such modified cds and methods of using such modified cds in the treatment of disease and disorders..
Catalytic strands of minimal hammerhead ribozymes and methods of using the same
The Regents Of The University Of California
March 22, 2018 - N°20180080022

Provided are minimal hammerhead ribozymes and catalytic strands thereof. Aspects of the present disclosure include a catalytic strand of a minimal hammerhead ribozyme, the catalytic strand including a catalytic core region, a stem i-forming region, a stem ii region, and a stem iii-forming region.
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Selective oxidation of 5-methylcytosine by tet-family proteins
The United States Of America, As Represented By The Secretary, Department Of Health & Human Servic
February 15, 2018 - N°20180044632

The present invention provides for novel methods for regulating and detecting the cytosine methylation status of dna. The invention is based upon identification of a novel and surprising catalytic activity for the family of tet proteins, namely tet1, tet2, tet3, and cxxc4.
Cell therapeutic agent for cancer treatment and combination therapy with same
Ajou University Industry-academic Cooperation Foundation
February 08, 2018 - N°20180037869

The present disclosure relates to a method for preparing cells for cancer treatment and a kit for cancer treatment comprising cells prepared by the method. The preparation method of the present disclosure can provide f cells, which, in spite of having no difference in the proliferative capacity compared with mesenchymal stem cells expressing cytosine deaminase that are harvested and used ...
Fluorocyclopentenylcytosine methods of use
January 25, 2018 - N°20180021338

Or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof. The disclosed subject matter further provides a method of treating one or more symptoms of cancer comprising administering to a subject in need thereof a compound of formula (i) and a process for preparing such..
Minimizing errors using uracil-dna-n-glycosylase
Abbott Molecular Inc.
January 18, 2018 - N°20180016641

Provided herein is technology relating to enzymatic modification of nucleic acids and particularly, but not exclusively, to methods and compositions relating to using uracil-dna-n-glycosylase for minimizing or eliminating errors in a dna sequence due to deamination of cytosine residues.. .
Quantitative substrate utilization in microbial ecology using stable isotope probing
Arizona Board Of Regents On Behalf Of Northern Arizona University
January 04, 2018 - N°20180002745

Methods modifying conventional sip so that isotopic incorporation into the genomes of individual microbial taxa can be quantified are described. Further, methods to quantify the baseline densities of the dna of individual microbial taxa without exposure to isotope tracers and then to quantify the change in dna density of each taxon caused by isotope incorporation are described.
Method for fragmenting a nucleic acid for sequencing
Population Genetics Technologies Ltd.
November 23, 2017 - N°20170335371

Providing herein, among other things, is a method for preparing a nucleic acid for sequencing. In some embodiments, the method comprises a) amplifying a nucleic acid template using a dntp mix that contains 5-methyl dctp, thereby producing product nucleic acid molecules that contains methylcytosines; b) digesting the product nucleic acid molecules with a methylation-dependent restriction endonuclease, thereby cleaving the product ...
Cancer marker and cancer determination method
Wako Pure Chemical Industries, Ltd.
November 09, 2017 - N°20170321247

The invention relates to a cancer marker, consisting of a portion of or all of the nucleotide sequence represented by seq id no: 1 in a foxb2 gene derived from a cell, and being continuous nucleotide sequences comprising at least the nucleotide sequence represented by seq id no: 2 or 3, wherein 30% or more of cytosines of the -cg- sequences present in said ...
Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections
November 02, 2017 - N°20170312283

Compounds, compositions, and methods of treatment and prevention of hiv infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine jak inhibitors.
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