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Brain patents

      

This page is updated frequently with new Brain-related patent applications.

Dynamic mesh system
A dynamic mesh system may be provided for a mesh including a network brain, a base node and a set of basic nodes. The system may provide operations to compare an old code with a new code, send a command to a base node instructing a set of basic nodes to change from an application mode to a boot mode, send a message including the new code to the set of basic nodes, update the new code on the set of basic nodes, and change the mesh by instructing the set of basic nodes to change to the application mode.
Sargon Partners


Eye-brain interface (ebi) controlling same
A method for calibrating an eye-brain interface (ebi) system controlled on the basis of eye movements and brain waves according to one embodiment of the present invention may comprise the steps of: providing an eye-brain calibration (ebc) interface for calibrating eye movements and brain waves simultaneously, wherein the ebc interface comprises a visual object and instructs a user to gaze into the visual object in a particular cognitive state; acquiring eye movements and brain waves of the user for the visual object included in the ebc interface; mapping the visual object and eye movements of the user; and mapping the particular cognitive state instructed to the user and brain waves of the user.. .
Looxid Labs Inc.


Prismatic contact lens
A class of prismatic contact lenses includes a first prism zone, having a first prism and a first optical power; and a progressive prism zone, adjacent to the first prism zone, having a progressive prism that varies from the first prism to a second prism. The prismatic contact lens can further comprise a second prism zone, adjacent to the progressive prism zone, having the second prism and a second optical power.
Eyebrain Medical, Inc.


Sensor-enabled mouthguard configured to enable monitoring of head impact data via multiple accelerometers, and data processing methods configured to analyse data derived from multiple accelerometers carried by a sensor-enabled mouthguard
Technology disclosed herein relates to sensor-enabled mouthguards. Embodiments have been particularly developed to provide sensor-enabled mouthguards configured to enable monitoring of head impact data via multiple accelerometers, and data processing methods configured to analyse data derived from multiple accelerometers carried by a sensor-enabled mouthguard.
Impact Technologies Australia Pty Ltd


Methods of assessing future memory loss by measuring polyunsaturated fatty acids
The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise determining the influx of polyunsaturated fatty acids (pu fas) into the brain from plasma in a test subject and comparing this measured influx to a normal standard influx.
Georgetown University


Oligodendroglioma drive genes
Oligodendrogliomas are the second most common malignant brain tumor in adults. These tumors often contain a chromosomal abnormality involving a pericentromeric fusion of chromosomes 1 and 19, resulting in losses of the entire short arm of the former and the long arm of the latter.
Duke University


Methods of treating brain edema
Provided are methods for treating or preventing brain edema in a subject by administering an inhibitor of slc26a11 to the subject. Also included are methods for preventing cell death, cell swelling, or elevated internal concentration of chloride ions in a cell by contacting the cell with an inhibitor of slc26a11..

Hydantoins that modulate bace-mediated app processing
In certain embodiments hydantoin compounds are provided herein that are effective to inhibit bace activity against app. Without being bound to a particular theory, it is believed the activity of the hydantoins identified herein appears to be associated with binding to bace and/or to app particularly when these moieties form a bace/app complex.
Buck Institute For Research On Aging


Methods and systems for controlling magentic fields and magnetic field induced current
Methods and systems to control magnetic fields and magnetic field induced currents, and to provide stimulations within a patient's body, e.g.: deep brain stimulation, in a non-invasive manner and with greater focus and control than has been afforded by prior known methods and systems. An array of magnetic coils is provided and positionable about a portion of a patient's body, and are configured to create a small region of a magnetic hole, or configured to create a small region of concentrated magnetic field strength, or their combination, and at depths within the patient's body in a focused region and sparing the surrounding tissues of the focused region, that have previously not been receptive to non-invasive tms methods, which are either focused but can affect only the surface and shadow areas, or that can reach certain depths but by doing so only through affecting large surface areas and deep tissue areas..
University Of Maryland, Baltimore County


Patterned stimulation for deep brain stimulation
This document discusses medical device for coupling to a plurality of implantable electrodes. The medical device includes a therapy circuit configured to deliver electrical neurostimulation energy to the plurality of implantable electrodes; and a control circuit operatively coupled to the therapy circuit.
Boston Scientific Neuromodulation Corporation


Pain management based on brain activity monitoring

This document discusses, among other things, systems and methods for managing pain of a subject. A system includes one or more physiological sensors configured to sense a physiological signal indicative of patient brain activity.
Boston Scientific Neuromodulation Corporation

Electrical microglial cell activation

A method is provided that includes positioning electrodes in or in contact with the head of a subject identified as in need of enhanced microglial cell activation. Control circuitry is activated to drive the electrodes to apply an electrical current to the brain of the subject, and to configure the electrical current to enhance microglial cell activation for taking up a substance from brain parenchyma.
Rainbow Medical Ltd.

Electrical treatment of alzheimer's disease

A method for treating hydrocephalus is provided, including disposing midplane treatment electrodes over a superior sagittal sinus of a brain, outside and in electrical contact with a skull of a head of a subject identified as suffering from hydrocephalus, and disposing lateral treatment electrodes between 1 and 12 cm of a sagittal midplane of the skull. The subject is treated by electroosmotically driving cerebrospinal fluid (csf) out of a ventricular system of the brain via a subarachnoid space of the brain to the superior sagittal sinus, by activating control circuitry to apply one or more treatment currents between (a) one or more of the midplane treatment electrodes and (b) one or more of the lateral treatment electrodes.
Rainbow Medical Ltd.

Beta amyloid staging

The present invention relates to a method of in vivo imaging and in particular to a method for the evaluation of in vivo images of beta amyloid (aβ) distribution in the brain of a subject suspected of having alzheimer's disease (ad). The method of the present invention provides more detailed information to the clinician as compared with prior art methods, facilitating identification of those subjects who will benefit most from disease modifying therapies..
Ge Healthcare Limited

Engineering synthetic brain penetrating gene vectors

A synthetic gene delivery platform with a dense surface coating of hydrophilic and neutrally charged peg, capable of rapid diffusion and widespread distribution in brain tissue, and highly effective gene delivery to target cells therein has been developed. Nanoparticles including nucleic acids, are formed of a blend of biocompatible hydrophilic cationic polymers and they hydrophilic cationic polymer conjugated to hydrophilic neutrally charged polymers such as polyethylene glycol.
The Johns Hopkins University

Nanoconjugates able to cross the blood-brain barrier

Polyvalent nanoconjugates address the critical challenges in therapeutic use. The single-entity, targeted therapeutic is able to cross the blood-brain barrier (bbb) and is thus effective in the treatment of central nervous system (cns) disorders.
Northwestern University

Conjugated biological molecules, pharmaceutical compositions and methods

Antibody drug conjugates (adc's) comprising a drug conjugated to antibody or antigen binding fragments thereof that bind to globo series antigen disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics.
Obi Pharma, Inc.

Products and methods for delivery of polynucleotides by adeno-associated virus for lysosomal storage disorders

The present invention relates to methods and materials useful for systemically delivering polynucleotides across the blood brain barrier using adeno-associated virus as a vector. For example, the present invention relates to methods and materials useful for systemically delivering α-n-acetylglucosamidinase polynucleotides to the central and peripheral nervous systems, as well as the somatic system.
Nationwide Children's Hospital, Inc

Glyceryl 3-hydroxybutyrates for traumatic brain injury

A method of treatment of mild to moderate non-penetrating closed traumatic brain injury and mild to moderate tbi due to surgical intervention using 3-hydroxybutyate glycerides is disclosed.. .
Neuroenergy Ventures, Inc.

The present invention concerns the prototypical pharmacologic profile of 3,3-diphenyl-n-(1-phenylethyl) propan-1-amine (fendiline), its enantiomers and its pharmaceutically acceptable salts characterized by their selective sigma-1 receptor affinity (vs, sigma-2 receptor: 14 to 18 nm vs 730 to 850 nm) and, therefore, prototypical allosteric antagonisms of brain n-methyl-d-aspartate receptors [nmda(−)], sodium channels [nav(−)] and discreet desensitization of muscarinic receptors [m(−)]. Of interest is the positive allosteric modulation of the γ-aminobutyric acid a (gaba) (a) and gaba (b) receptors, originating brain pro-gabaergic and anti-glutamatergic activities and also an unique pharmacological profile which antagonize all the components of the vicious circle generated in the brain by glutamate/gaba imbalance, with protective and preventive action against all the behavioral abnormalities, the cognitive deficits and neurotoxicities, in neurodegenerative (alzheimer's, parkinson's huntington's and multiple sclerosis) diseases and neurodevelopmental diseases (autism spectrum disorders and related syndromes)..

Compositions comprising a dendrimer-resveratrol complex and methods for making and using the same

Compositions and pharmaceutical compositions including a dendrimer-resveratrol complex and methods for making and using the compositions are described herein. Methods of treating cancer, cardiovascular disease, cardiac failure, diabetes, alzheimer's disease, parkinson's disease and other brain diseases, fatty liver disease, obesity, cataracts, osteoporosis, muscle wasting, sleep disorders, acoustic trauma, inflammatory disease, psoriasis, arthritis, colitis, aging, viral disease, reproductive disease, and skin conditions or disorders including administering a therapeutically effective amount of the compositions to a subject in need are also provided.
Concordia University

Embolic protection during percutaneous heart valve replacement and similar procedures

Various devices are described to provide filtering of flow from the aorta to the left carotid artery and the right carotid artery. The filters can be brought into a desired position through one or more peripheral arteries.
Lumen Biomedical, Inc.

System and methods for monitoring and improving cognitive flexibility

A system and methods for monitoring and controlling a mental state of a subject are provided. In some aspects, a method includes receiving physiological and behavioral data acquired using the plurality of sensors while the subject is performing a task, and applying, using the data, a state-space framework to determine a plurality of decoder parameters correlating brain activity and behavior with a mental state of the subject.
Trustees Of Boston University

Probe for measuring a patient's bulbocavernosus muscle reflex

A method and system to obtain and process data indicative of muscle reflexes for screening and/or diagnosing a patient with a brain injury or spinal cord injury, and especially for obtaining and processing data indicative of reflexes from the bulbospongiosus muscle. Certain embodiments employ a novel electromechanical probe for stimulating the bulbospongiosus muscle to identify a time of the stimulation so that electrical responses from electrodes on the patient's skin can be identified for analysis..
Uroval, Inc.

Brain-mobile interface optimization using internet-of-things

A brain-mobile interface (bmoi) system is provided. A control circuit is configured to execute a predictive model to generate a defined number of predicted signal features in future time based on a number of signal features extracted from a first type sensory data (e.g., electroencephalogram (eeg) data).
Arizona Board Of Regents On Behalf Of Arizona Stat E University

User input validation and verification for augmented and mixed reality experiences

A head-mounted display (hmd) system includes an hmd device worn on a head of a user. The hmd device incorporates electroencephalography (eeg) interfaces for monitoring the brain of the human subject during interaction with the hmd device.
Daqri, Llc

Selective cysteine protease inhibitors and uses thereof

The present invention relates to compounds of formula i, ii, ia-va, iva1-iva5, iiia1-iiia5 and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds for the selective inhibition of one or more cysteine proteases.
Genesis Technologies Limited

Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease

Disclosed herein are compounds which inhibit the kinase activity of dual leucine zipper (dlk) kinase (map3k12), pharmaceutical compositions, and methods of treatment of dlk-mediated diseases, such as neurological diseases that result from traumatic injury to central nervous system and peripheral nervous system neurons (e.g. Stroke, traumatic brain injury, spinal cord injury), or that result from a chronic neurodegenerative condition (e.g.
Board Of Regents, The University Of Texas System

In vitro epithelial models comprising lamina propria-derived cells

An in vitro microfluidic “organ-on-chip” is described herein that mimics the structure and at least one function of specific areas of the epithelial system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and the associated tissue specific epithelial cells and endothelial cells.
Emulate, Inc.

Patient-specific functional cranioplasty with integrated ultrasonic transmitter arrangement for neuromodulation and opening of the blood brain barrier

The invention relates to an ultrasonic transmitter arrangement (1) with a plurality of ultrasonic transmitters (2) arranged on the arrangement whose emittable ultrasonic waves are focused toward a common focus (3). The arrangement (1) is embodied as a cranial bone implant (4) that can be implanted in the cranial bones (5) of a person as a replacement for one or more parts of the cranial bone (5), with the common focus (3) of the entire arrangement being arranged in a defined region of the brain (6) in the implanted state..

Method and brain function enhancement

In one aspect, a system for in vivo and transcranial stimulation of brain tissue of a subject may include at least one light source, a controller to control operation of the light source, a signal detecting unit and a processor configured to receive signals from the signal detecting unit, analyze the signals and generate a feedback signal to the controller to control the light source until optimal results are obtained. In one embodiment, the light source is a laser instrument and the wavelength can range from 800 to 1100 nm.

Methods for delivery of optical signals to tissue for the treatment of a disease or condition

Embodiments described herein provide methods for treating various conditions and diseases using an optical signal. In one or more embodiments an apparatus is providing having an optical window, which is used to deliver an optical signal to provide stimulation to one or more tissue sites in the body such as the brain, optic nerve, eye, ganglia, spine, or other like site.
Incube Labs, Llc

Flexible complementary metal-oxide-semiconductor probes for chronic, large-scale neural stimulation and recording

Systems and methods for providing neural stimulation and recording on a subject using flexible complementary cmos probes are provided. Disclosed systems can include a flexible probe adapted for insertion into a portion of a brain of the subject, the flexible probe comprising a tail portion and a head portion.
The Trustees Of Columbia University In The City Of New York

Method of manufacturing feedthrough

A method of manufacturing a feedthrough having an enhanced hermetic sealing and used for a human implantable medical device such as a deep brain stimulator, a implantable aed, a implantable spinal cord stimulator and so on. Thus, more enhanced reproducibility and productivity in the diffusion welding and the laser hole machining may be guaranteed in the present method of manufacturing the feedthrough, compared to the conventional method using the ceramic metallizing and the brazing..
Osong Medical Innovation Foundation

System and feedback-driven neuromodulation

Systems and methods are provided for neuromodulation with simultaneous stimulation and reception of neuronal response. A closed-loop control system provides the ability to modulate any combination of at least five parameters of stimulation (magnitude, frequency, amplitude, time, and phase) based on any combination of at least five parameters of received signals.
Regents Of The University Of Minnesota

System and pain relief based on frequency based analysis of temporal nociceptive signals

An apparatus, system and technique selectively eliminates the noxious signal components in a neuronal signal by creating an interfering electrical signal that is tuned to a given frequency corresponding to the oscillatory pattern of the noxious signal, resulting in a modified neuronal signal that substantially reproduces a normal, no-pain neuronal signal. The disclosed system and technique of pain relief is based on the hypothesis that the temporal profile of pain signals encodes particular components that oscillate at unique and quantifiable frequencies, which are responsible for pain processing in the brain..

Carrier for use in delivering drug, conjugate, composition comprising same, and administrating same

The present invention provides a vesicle, a conjugate, a composition comprising the vesicle or the conjugate, for use in delivering a drug to the brain, and a method for administering the same. The composition of the present invention is a composition for administration to a subject according to a dosing regimen, comprising a carrier for drug delivery, wherein the dosing regimen comprises administering the composition to a subject who has been fasted or caused to have hypoglycemia and inducing an increase in blood glucose level in the subject, and the carrier is modified at the outer surface thereof with a glut1 ligand..
National University Corporation Tokyo Medical And Dental University

Therapeutic compositions of alpha-l-iduronidase, iduronate-2-sulfatase, and alpha-galactosidase a and methods of use thereof

The present invention provides pharmaceutical compositions comprising an a blood brain barrier peptide and a human peptide, such as an alpha-l-iduronidase (idua) protein, an iduronate-2-sulfatase protein (ids) protein, or an a galactosidase a protein (α-gal a) protein. The invention further provides methods of use for treating mucopolysaccharidosis type i (mps i), including hurler syndrome, hurler-scheie syndrome and scheie syndrome; methods of use for treating hunter syndrome; and methods of use for treating fabry disease..
Alexion Pharmaceuticals, Inc.

Drug regimen for treatment of cerebral ischemia

Treatment of subjects experiencing cerebral ischemia is improved when the treatment employs a thrombolytic and an inhibitor against vascular endothelial growth factor receptor signal transduction (vegf-rst) at a reduced, low dosage compared to that used to treat cancer patients. The treatment is also improved to permit point-of-care use by formulating protein drugs for long term stability at room temperature, providing doses appropriate for the method, and by combining the therapeutic agents with a point-of-care diagnostic for blood brain barrier integrity..
Shimojani, Llc

Glucose oxidase compositions as a neonate anticonvulsant

Neonatal seizure is different from adult seizure, and many antiepileptic drugs that are effective in adults often fail to treat neonatal seizure. Gluconic acid, a natural organic acid enriched in fruits and honey, and the glucose oxidase enzyme, is shown herein to potently inhibit neonatal epilepsy both in vitro and in vivo.
The Penn State Research Foundation

Use of levocetirizine and montelukast in the treatment of traumatic injury

The embodiments described herein include methods and formulations for treating lung and brain injury. The methods and formulations include, but are not limited to, methods and formulations for delivering effective concentrations of levocetirizine and montelukast to a patient in need.
Inflammatory Response Research, Inc.

Attention, comprehension, and drowsiness monitoring via head mounted device supporting augmented and mixed reality experiences

A head mounted display (hmd) system includes an hmd device worn on a head of a user. The hmd device incorporates electroencephalography (eeg) interfaces for monitoring the brain of a human subject during interaction with the hmd device.
Daqri, Llc

System and signatures for a multi-modal physiological periodic biomarker assessment

Methods for diagnosing autism and/or autism spectrum disorder (asd) of a subject include establishing baseline brain wave patterns of the subject by having the subject perform a series of task and measuring brain waves during the tasks using an eeg measurement device, applying a light stimulus or images to the subject's eyes and capturing eye movements and/or changes in facial expression in response to the light stimulus or images, and giving a neuropsychological and cognition battery of tasks to the subject to generate a provoked cognitive assessment of the subject. A processing device correlates the baseline brain wave patterns, eye movements and/or facial expressions, and provoked cognitive assessment of the subject to profile data indicative of autism and/or asd.
Cerora, Inc.

Systems and methods for neuro-feedback training using video games

A method and system for neuro-feedback training are disclosed. According to certain embodiments, the method may include receiving, by a processor via a communication network, a brainwave signal measured by at least one sensor attached to a user.
Brainco Inc.

Systems and methods for neuro-feedback training using iot devices

A method and system for neuro-feedback training are disclosed. According to certain embodiments, the method may include receiving, by a processor via a communication network, a brainwave signal measured by at least one sensor attached to a user.
Brainco Inc.

Low molecular weight polyethylene glycol drug conjugates having improved drug biological activity

Provided are polyethylene glycol drug conjugates of general formula (i), (ii) or (iii) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules.
Sunglory Beheer B.v.

Electrolyte for lithium secondary battery and lithium secondary battery comprising same

The present invention relates to an electrolyte for a lithium secondary battery, containing, as an electrolyte additive, at least one compound selected from the group consisting of compounds represented by chemical formulas 1 to 4 below, and can provide a lithium secondary battery which has improved anodic film forming characteristics and battery resistance characteristics at high voltages.. .
Soulbrain Co., Ltd.

Method and device for transmitting and receiving audio data

An artificial intelligence (ai) system configured to simulate functions of a human brain, such as recognition, determination, etc., by using a machine learning algorithm, such as deep learning, etc., and an application thereof. The ai system includes a method performed by a device to transmit and receive audio data to and from another device includes obtaining a voice input that is input by a first user of the device, obtaining recognition information indicating a meaning of the obtained voice input, transmitting the obtained voice input to the other device, determining whether an abnormal situation occurs, in which a second user of the other device does not understand the transmitted voice input, and transmitting the obtained recognition information to the other device, based on a result of the determination..
Samsung Electronics Co., Ltd.

Composition for etching

The disclosure is related to a composition for etching, a method for manufacturing the composition, and a method for fabricating a semiconductor using the same. The composition may include a first inorganic acid, at least one of silane inorganic acid salts produced by reaction between a second inorganic acid and a silane compound, and a solvent.
Soulbrain Co., Ltd.

Fusion protein containing bdnf

Disclosed is a fusion protein containing a brain-derived neurotrophic factor (bdnf). The fusion protein is a fusion protein of bdnf and a specific range of human anti-transferrin receptor antibody, which makes bdnf administered into the blood able to pass through the blood-brain barrier..
Jcr Pharmaceuticals Co., Ltd.

Methods for the treatment and diagnosis of alzheimer's disease and traumatic brain injuries

The invention relates to the use of hnrnpc-expressing vectors for preventing and/or treating a tauopathy, such as alzheimer's disease. The invention relates to methods for detecting a risk of developing a tauopathy such alzheimer's disease in a patient, comprising the step of detecting the level of hnrnpc in a biological sample obtained from said patient..
Universite Pierre Et Marie Curie (paris 6)

Neuroactive steroids, compositions, and uses thereof

Provided herein are 19-nor c3, 3-disubstituted steroids of formula (i): and pharmaceutically acceptable salts thereof; wherein r1, r2, r3, and r4 are as defined herein, and a is a heteroaryl ring system comprising 3 or 4 nitrogens as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus..
Sage Therapeutics, Inc.

Radiosurgical neuromodulation devices, systems, and methods for treatment of behavioral disorders by external application of ionizing radiation

Radiosurgical techniques and systems treat behavioral disorders (such as depression, obsessive-compulsive disorder (“ocd”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder.

Neurostimulators and stimulation systems

In accordance with the present invention, various embodiments of neurostimulators and stimulation systems are disclosed that provide different shapes and patterns of stimulus pulses and trains of pulses with fixed and no fixed frequencies. The neurostimulator can be configured to provide high frequency stimulation and also be implantable in the head or neck regions in order to stimulate nerves and nerve ganglions in the head and neck regions and also stimulate the brain..
The Alfred E. Mann Foundation For Scientific Research

Device and effective invasive two-stage neurostimulation

A device for stimulating neurons that includes a stimulation unit implantable in the body of a patient and having stimulation elements that stimulate neurons in the brain and/or spinal cord. A control unit controls the stimulation unit during first and second time intervals in different stimulation modes.
Forschungszentrum Juelich Gmbh

Closed loop deep brain stimulation systems and methods

The present disclosure relates generally to systems, methods, and devices for closed loop deep brain stimulation. In particular, a neural signal is measured and provided to software.
Battelle Memorial Institute

Electrical stimulation system

The present disclosure relates to an electrical stimulation system, comprising, in accordance with one exemplary embodiment of the present invention, an analysis portion recognizing a brain activation pattern of a first user by analyzing a brainwave signal of the first user measured by a first electrical stimulation apparatus; and a stimulating portion applying an electrical stimulation to the brain of a second user on the basis of the information on the recognized brain activation pattern of the first user, wherein the first electrical stimulation apparatus includes a detecting portion detecting the second user's approach.. .
Ybrain Inc.

Compositions for the treatment of cancer and uses thereof

The invention pertains to compositions comprising inhibitors of pi3k, akt and/or mtor, one or more 4-quinolinemethanols and a pharmaceutically acceptable excipient. These compositions can contain subtherapeutic amounts of each active ingredient (pi3k, akt, mtor, one or more 4-quinolinemethanols and various combinations thereof).
University Of Florida Research Foundation Incorporated

Stereotactic device for implantation of permanent implants into a rodent brain

Stereotactic systems and implantation methods that can be designed for use with a specific species and further customized for use with an individual within the species are provided. The stereotactic system can include an implant jig that can model a tissue or organ in which a target tissue area is located.
The Regents Of The University Of California

Minimally invasive focused ultrasound (mifus) for brain surgery

Hifu (high-intensity focused ultrasound) sometimes fus or mifus is a highly precise medical procedure using high-intensity focused ultrasound to heat and destroy pathogenic tissue rapidly in the brain for neurosurgical purposes, by causing coagulation necrosis. Here we have described a system that uses specially designed micro-transducer heads that are placed inside the later ventricles for the purposes of mifus lesioning of brain targets under real time mri, endoscopic and doppler guidance.
The Johns Hopkins University

Systems and methods for performing transcranial ultrasound therapeutic and imaging procedures

Systems and methods are provided for performing transcranial diagnostic procedures using a transcranial ultrasound transducer array. The array elements are positioned and oriented such that far field regions respectively associated therewith spatially overlap within the brain of a patient.
Sunnybrook Research Institute

Detecting apparatus and associated imaging method

The invention concerns a detecting apparatus (12) for imaging at least two areas of a brain of a subject (10), the detecting apparatus (12) comprising:—a holder comprising:—a frame (14) devoted to be cemented on the skull of the subject (10), the frame (14) delimitating an inner portion (18) which is transparent to ultrasound waves,—a removable imaging device comprising:—a platform (16) delimitating an inner space (28), the inner space (28) facing the inner portion (18),—a fixing element (30) adapted to temporary fix and lock the platform (16) to the holder,—an ultrasound probe (32), and—a moving stage (34) holding the ultrasound probe (32) and being adapted to move the ultrasound probe (32) within the inner space (28).. .
Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris

Device based on virtual reality interactive technology and real-time monitoring technology of brain function

The present invention provides a device based on virtual reality interactive technology and real-time monitoring technology of brain function, which relates to the field of medical treatment and intelligent device. It comprises a virtual reality interactive module, a human body data collecting module, a data synchronization module, and a control module for data processing and analysis; wherein the virtual reality interactive module is responsible for providing specific virtual reality contents to induce specific emotion of a user and for collecting an interactive behavior data of the user when interacting with the virtual reality interactive module; the human body data collecting module is responsible for collecting a real-time physiological sign data of the user; the data synchronization module is responsible for synchronizing the real-time collected interactive behavior data and the real-time collected physiological sign data of the user; the control module for data processing and analysis is responsible for analysing and processing the original physiological signs data and finally obtains, in connection with big data, a health state of the brain function of the user.
South China University Of Technology

Eeg monitor with capacitive electrodes and monitoring brain waves

A wearable eeg monitor for continuously monitoring the eeg of a user through capacitive coupling to an ear canal of a user includes an ear insert (1) for positioning within the human ear canal, having at least two capacitive electrodes (16) for recording a signal. The electrodes are coated with a dielectricum for electrical insulation.
Widex A/s

Erchonia Corporation

. .

Method and filtering video

An artificial intelligence (ai) system for simulating functions such as recognition, determination, and so forth of a human brain by using a mechanical learning algorithm such as deep learning, or the like, and an application thereof are provided. A method of filtering video by a device is provided.
Samsung Electronics Co., Ltd.

Dynamic recovery from a split-brain failure in edge nodes

Some embodiments provide a method for employing the management and control system of a network to dynamically recover from a split-brain condition in the edge nodes of the network. The method of some embodiments takes a corrective action to automatically recover from a split-brain failure occurred at a pair of high availability (ha) edge nodes of the network.
Nicira, Inc.

Method and teaching and cognitive enhancement

The present invention is a teaching and learning tool built on the principle that the human sense of touch makes a significant contribution in the visualization of objects. Sighted individuals can produce visual images inside the brain (commonly referred to as the “mind's eye”) via the sense of touch, where we use our minds, rather than our eyes, to visualize concrete objects allowing us to “get a picture” of that object.

Integrated learning device

Invention item is applied as producing the brain waves of beta, alpha, theta and delta improved by integrating information of modern physiology and psychology that increases learning grade, facilitates and accelerates the learning with its effects to increment of the learning concentration of the brain waves, to remembrance and to development of the memory, then transferring these waves to the person audio-visually in specific periods of time along the learning duration.. .
Biooram Sagitim Danismanlik Ve Kozmetik ÜrÜnleri Tic. Ltd. Sti

Natural transfer of knowledge between human and artificial intelligence

A system and method for providing natural training to an ai/agent/bot. In one embodiment, the system and method include receiving a first input indicating a trainer's desire to provide knowledge or know-how to an artificially-intelligent agent; creating a first natural training session to capture the knowledge or know-how; receiving the knowledge or know-how from the trainer; sending a first response to the trainer, the first response requesting a first prompt that, when received by the artificially-intelligent agent, prompts the artificially-intelligent agent to use the knowledge or know-how captured in the first natural training session to respond; receiving a second input from the trainer including a first prompt; validating a capability of the artificially-intelligent agent to correctly respond to requests related to the knowledge or know-how captured by the first training session; and receiving additional..
Xbrain, Inc.

Method and electronic device for providing text-related image

An artificial intelligence (ai) system for simulating functions such as recognition, determination, and so forth of human brains by using a mechanical learning algorithm like deep learning, or the like, and an application thereof is provided. A method of providing a text-related image is provided.
Samsung Electronics Co., Ltd.

Speech recognition method and apparatus

A speech recognition method and apparatus for performing speech recognition in response to an activation word determined based on a situation are provided. The speech recognition method and apparatus include an artificial intelligence (ai) system and its application, which simulates functions such as recognition and judgment of a human brain using a machine learning algorithm such as deep learning..
Samsung Electronics Co., Ltd.

Devices, providing photostimulation and imaging of structures

According to exemplary embodiments of the present disclosure, it is possible to provide method, system, arrangement, computer-accessible medium and device to stimulate individual neurons in brain slices in any arbitrary spatio-temporal pattern, using two-photon uncaging of photo-sensitive compounds such as mni-glutamate and/or rubi-glutamate with beam multiplexing. Such exemplary method and device can have single-cell and three-dimensional precision.
The Trustees Of Columbia University In The City Of New York

Method for diagnosing a brain tumour in a human

An in vitro method for diagnosing a brain tumour in a human test subject comprising: determining the concentration of at least two metabolites comprised in a biofluid sample obtained from the human test subject; comparing the concentration of the at least two metabolites in the biofluid sample with the concentration of the same at least two metabolites in at least one reference standard obtained from a non-tumour bearing subject and/or a tumour bearing subject; and identifying a concentration difference for each of the at least two metabolites in the biofluid sample relative to the reference standard; wherein the concentration difference for each of the at least two metabolites in the biofluid sample correlates with the presence of a brain tumour. The invention also relates to a data-storage medium comprising data obtained by a method of the invention..
Oxford University Innovation Limited

Methods for treating neural cell swelling

A composition comprising a novel ca2+-activated, [atp]i-sensitive nonspecific cation (ncca-atp) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [ca]i.
The United States Of America As Represented By The Deparment Of Veterans Affairs

Improved cell-permeable (icp) parkin recombinant protein and use thereof

Disclosed are improved cell-permeable parkin recombinant proteins (icp-parkin) which have been developed as a protein-based anti-neurodegenerative agent for efficient bbb-penetration to effectively deliver the recombinant protein into the brain. A parkin protein, a dopaminergic neuronal cell death inhibitor, has been fused with a newly developed advanced macromolecule transduction domain (amtd) and preferably with a solubilization domain (sd) to increase the solubility/yield and cell-/tissue-permeability of the recombinant protein.
Cellivery Therapeutics, Inc.

Methods of treating cancer

Compositions and methods of treating a subject with cancer are described. The methods include administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a compound with the dual characteristics or restoring function of the c-cbl ubiquitin ligase in cancer cells and in also worsening sublethal lysosomal dysfunction, preferably in combination with an agent capable of making cancer cells more oxidized.
The University Of Rochester

Anti-human transferrin receptor antibody permeating blood-brain barrier

Disclosed are a means to convert compounds having physiological or pharmacological activity and unable to pass through the blood-brain barrier into a form that allows them to pass through the blood-brain barrier, and compounds converted thereby. The means is an anti-human transferrin receptor antibody and the converted compounds are molecular conjugates between physiologically active protein or pharmacologically active low-molecular-weight compounds and an anti-human transferrin receptor antibody..
Jcr Pharmaceuticals Co., Ltd.

Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment

This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those benzodiazepine derivatives and methods of using those derivatives or compositions in treating cognitive impairment associated with central nervous system (cns) disorders. In particular, it relates to the use of a α5-containing gabaa receptor agonist (e.g., a α5-containing gabaa receptor positive allosteric modulator) as described herein in treating cognitive impairment associated with central nervous system (cns) disorders in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, mild cognitive impairment (mci), amnestic mci (amci), age-associated memory impairment (aami), age related cognitive decline (arcd), dementia, alzheimer's disease(ad), prodromal ad, post traumatic stress disorder (ptsd), schizophrenia, bipolar disorder, amyotrophic lateral sclerosis (als), cancer-therapy-related cognitive impairment, mental retardation, parkinson's disease (pd), autism spectrum disorders, fragile x disorder, rett syndrome, compulsive behavior, and substance addiction.
Agenebio, Inc.

Psychotropic agents and uses thereof

Novel amisulpride derivatives and pharmaceutical compositions thereof are disclosed. The amisulpride derivative disclosed herein or a pharmaceutical composition thereof may have better membrane permeability compared to amisulpride.
Lb Pharmaceuticals Inc.

Low profile articulation jaw joint stabilizer device

The diagnosed soft tissue or brain injury component of concussions is generally defined by the symptoms of the temporal lobe manifestations. However, there is an undiagnosed structural fractured component of concussions occurring within the jaw joint complex which is the focus of this invention.

Methods of treating autism using light therapy

A method for treating autism. Light energy is applied externally to a patient's scalp on the skull near the frontal lobes.
Erchonia Corporation

Methods of treating a healthy brain using light therapy

Light energy is applied externally to the head of a patient who has a healthy brain to activate portions of the brain. The light is applied to the patient's scalp all over the patient's head or to desired portions of the scalp to activate desired portions of the brain.
Erchonia Corporation

Treatment of neurodegenerative diseases using light therapy

The wavelength of the applied light range from about 400-760 nm, and in a preferred embodiment is about 640 nm. The applied light energy can be applied with a pulse frequencies that mimic healthy brain function of alpha, beta, delta, and theta waves.

Support device and user terminal

A support device includes: a data acquisition unit which acquires brain activity data of a user; a stimulation unit which gives an electromagnetic stimulus corresponding to the brain activity data, to a head of the user; and a brain wave storage unit which stores a change in the brain activity data. The support device is configured to give an electromagnetic stimulus which causes alpha waves of the brain activity data to change, when acquiring the brain activity data..
Seiko Epson Corporation

Methods of delivery of transgenes for treating brain diseases

The present disclosure provides methods of treating a disease or delivering a therapeutic agent to a mammal comprising administering to the mammal's deep cerebella nuclei a recombinant adeno-associated virus (raav) particle comprising an aav capsid protein and a vector comprising a nucleic acid encoding a therapeutic agent inserted between a pair of aav inverted terminal repeats in a manner effective to infect the cns cell of the non-rodent mammal such that the cns cell expresses the therapeutic agent in the non-rodent mammal.. .
University Of Iowa Research Foundation

Novel prodrug salts

Provided are novel prodrug salts of selective aquaporin inhibitors, their use as pharmaceuticals, and pharmaceutical compositions comprising them, and novel processes for their synthesis and novel intermediates for use in their synthesis. Also provided is use of a compound for the prophylaxis, treatment, and control of aquaporin-mediated conditions.
Aeromics, Inc.

Agent for improving brain function and agent for preventing or treating cognitive impairment

An agent for improving brain function and agent for preventing or treating cognitive impairment, which comprises: 5 to 50 parts by weight of a protein; 5 to 80 parts by weight of a medium-chain fatty acid triglyceride as a lipid; and 1 to 50 parts by weight of a carbohydrate, per 100 parts by weight.. .
National Center Of Neurology And Psychiatry

Combination therapy comprising an omega-3 fatty acid, a folate species and a vitamin b12 species

The present invention provides a combined therapy comprising the use of one or more omega-3 fatty acids and one or more b vitamins and for treating cognitive impairment, such cognitive impairment disorders include, especially but not exclusively, mild cognitive impairment (mci) and alzheimer's disease (ad). The present invention also provides a treatment: for individuals suffering from cognitive impairment disorders that occur as a result of brain or cerebral atrophy, the invention includes inter alma methods of treating and/or reducing progression of brain atrophy and pharmaceutical compositions and nutritional supplements therefor..
Isis Innovation Limited

Chitosan nanofibres containing bioactive compounds

The invention relates to self-assembled nanofibers of chitosan and bioactive compounds for use as nutraceuticals or drugs. Suitable bioactive compounds include molecules of a low molecular size with acid or lactone groups, aromatic rings and hydroxyls.
Universidad De Valparaiso

Method and targeted micro vibration

In accordance with one embodiment, a method and apparatus for micro vibration, generally comprising a handheld device with a terminus having a micro vibration bar, is provided for use in combination with methods of use designed to disrupt the brain's perception of painful stimuli originating from a pain source nearby or imminently adjacent to the apparatus, thereby alleviating in part or in total the subject's perceived pain.. .

System and identification of brain injury

A method for identifying brain injuries in a test subject includes acquiring, at a selected number of instances across a selected time interval, a set of signals indicative of force from a set of force sensors when the test subject stands on a pressure measurement unit. The method includes calculating a center-of-pressure of the test subject at the selected number of instances across the selected time interval based on the acquired set of signals from the set of force sensors.
Motometrix Inc.

Diagnosis of mild traumatic brain injury

A stimulus is displayed in a visual field on a stimulus side (e.g., right or left) of a subject. An input is received from an input side of the subject.
The Research Foundation For The State University Of New York

Evaluation of inhibitory circuit and use thereof

A more practical method for evaluating an inhibitory circuit applicable to a living body, and the use thereof. Herein the action of an inhibitory circuit on an excitatory circuit is evaluated on the basis of attenuation of the brain activity produced by activation of an excitatory circuit by the input of an inhibitory circuit by performing a step for inputting an inhibitory circuit by applying a second trigger in advance of a first trigger to an excitatory circuit activated by a first trigger which is a stimulus or challenge..
Tokai Optical Co., Ltd.

Brain image reconstruction apparatus

A brain image reconstruction apparatus can reconstruct a brain image as a sharper image. A brain image reconstruction apparatus has a data acquisition unit that acquires brain activity data of a user; a brain image reconstructor that detects image information from the brain activity data and constructs a brain image; a linguistic information detector that detects linguistic information from the brain activity data; an image database that stores sample images corresponding to the linguistic information; and an image processor that superimposes the sample image with the brain image, and constructs a process image..
Seiko Epson Corporation

Brain activity estimation device

A brain activity estimation device includes a brain activity estimation portion. The brain activity estimation portion includes a blood-circulation-amount calculating unit and an estimation unit.
Tokyo Institute Of Technology

Nutritional compositions containing inositol and uses thereof

Provided are nutritional compositions containing inositol. Further disclosed are methods for promoting optimal and functional synaptic development in a target subject via administering the nutritional composition containing inositol to the target subject.
Mead Johnson Nutrition Company

Methods and compositions for cryopreservation of endothelial cells

Brain microvascular endothelial cells (bmecs) can be generated from pluripotent stem cells, and possess membrane barrier functions along with capability for maturation into other developing tissues. This cell type has not been successfully frozen with loss of significant viability and/or bmec functional properties.
Cedars-sinai Medical Center

Systems and methods for enhancing or affecting neural stimulation efficiency and/of efficacy

Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters.
Advanced Neuromodulation Systems, Inc., D/b/a St. Medical Neuromodulation Division

Test panel to measure blood neurotoxin levels in prematernal women and for the general public in relation to mental disorders of the aging

A prescribed diagnostic blood test panel is directed to countering autistic and mentally affected births and assessing the continued healthy mental state of the elderly. Six neurotoxins in the blood are analyzed, five of which can produce damage to the brain, namely aluminum, arsenic, lead, mercury and manganese.

Sensing and actuation of biological function using addressable transmitters operated as magnetic spins

Methods and apparatuses for sensing biological functions are disclosed. Sensors can be implanted in an organ, such as the brain, and a magnetic field gradient applied to the biological tissue.
California Institute Of Technology

Recombinant adeno-associated vectors for targeted treatment

Novel adeno-associated virus (aav) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues.
City Of Hope

Antitumor agent

This invention provides a composition and a method for treating or preventing a subject having a tumor that more highly expresses a tug1 gene than in normal tissues (e.g., brain tumor, breast cancer, colon cancer, prostate cancer, liver cancer, lung cancer, leukemia, or lymphoma), which composition comprises, as an active ingredient, a nucleic acid that inhibits the high expression of the tug1 gene in tumor stem cells.. .
Public University Corporation Nagoya City University

Etching composition and fabricating semiconductor device by using the same

An etching composition may include a peracetic acid mixture, a fluorine compound, an organic solvent (e.g., acetate-series organic solvent), and water. The etching composition may be used to selectively etch silicon-germanium (sige)..
Soulbrain Co., Ltd.

Antibodies against the rgm a protein and uses thereof

The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize rgm a protein. Specifically, these antibodies have the ability to inhibit the binding of rgm a to its receptor and/or coreceptors.
Abbvie Inc.

Targeted neurogenesis stimulated by aerobic exercise with brain function-specific tasks

A system targeted neurogenesis stimulated by aerobic exercise with brain function-specific tasks. A user may participate in game-like tasks that challenge specific brain functions has been developed.
Blue Goji Llc

Treatment of autoimmune diseases with deep brain stimulation

Techniques using electrical stimulation for treating an autoimmune disease by means of an implantable pulse generator and at least one electrode. An electrode lead is surgically implanted in a region of the insular cortex to deliver electrical stimulation.
Aleva Neurotherapeutics

Compositions and methods for transport across the blood brain barrier

Compositions and methods are provided including a transporter peptide derived from the loop2 domain of the neuronally-derived lynx protein which can be conjugated to an effector agent to form a transporter-effector complex for transport of the therapeutic effector agent to a target that is found across the blood brain barrier.. .
Ophidion Inc.

Method of treating neurological disorders with stem cell therapy

A method for isolating self-renewable stem cells from pluripotent stem cells (embryonic or induced) by treating the pluripotent stem cells with a combination of epidermal growth factor and basic growth factor, wherein upon treatment, the pluripotent stem cells differentiate into self-renewable neural stem cells. The self-renewable stem cells may be further induced to dopaminergic neurons through treatment with dopaminergic inducing media.
Neoneuron Llc

Composition for treating brain lesions

Some embodiments are directed to a pharmaceutical composition which includes a biocompatible polymer and a eukaryotic cell to be used as a drug for the prevention and/or treatment of tissue lesions of the central nervous system caused by cerebral vascular ischaemia. Some embodiments are also directed to a pharmaceutical kit which includes a biocompatible polymer and a eukaryotic cell for the prevention and/or treatment of tissue lesions of the central nervous system caused by cerebral vascular ischaemia.
Universite De Caen Basse-normandie

Navigated bipolar forceps

An all-in-one, light-weight navigated bipolar forceps allow the surgeon to stay focused on and not have to take their eyes off the surgical site that (s)he is operating on, such as the brain. The navigated bipolar forceps would have a navigated frame that would be positioned at the superior end of the bipolar forceps instrument.

Cannula with proximally mounted camera

A cannula system and method for accessing a blood mass in the brain. The system comprises a cannula with a camera mounted on the proximal end of the cannula with a view into the cannula lumen and the surgical field below the lumen.
Rebound Therapeutics Corporation

Sensor fusion for brain measurement

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for receiving brain activity data of a user from a brainwave sensor and user physiological data from a non-brainwave sensor, where the brain activity data represents a brainwave pattern related to a physiological activity of the user and a brainwave pattern related to a mental activity of the user. Identifying a physiological action of the user based on the user physiological data.
X Development Llc

Eyewear

A technique to detect an eye potential of a wearer of an eyewear by using an electrode abutting on the glabella of the wearer has been known, but it is desirable to surely cause the electrode to abut on the glabella so as to prevent deterioration in the detection accuracy of detecting a biosignal indicating an eye potential, myogenic potential, brain wave or the like. In view of this, an eyewear including: a frame; a first electrode that abuts on a glabella of a wearer of the eyewear; and an electrode holding unit that holds the first electrode such that a distance between the frame and the first electrode is changeable is included..
Jin Co., Ltd.

Eye sensor, system and method

An eye sensor, system and method for measuring fixational eye movements of an individual's eyeball (e.g., ocular microtremors and microsaccades) to provide a variable voltage biosignal for measuring the individual's brainstem activity is provided. The eye sensor comprises a sensor mounted on the individual's closed or opened eyelid so as to be deflected by the fixational eye movements of the eyeball.
Brainstem Biometrics, Inc.

Commissariat A L'energie Atomique Et Aux Energies Alternatives

. .

Methods and detecting and handling split brain issues in a link aggregation group

Methods and apparatus for operating a virtual node in a lag that includes a first virtual node and a second virtual node are disclosed. The first virtual node includes at least a first fellow node and a second fellow node.
Telefonaktiebolaget Lm Ericsson (publ)

Histone anti-cancer vaccines

The present invention pertains to novel immunogenic peptide sequences that can be used as vaccines in the treatment of cancer diseases such as brain cancers and specifically glioma. The cancer vaccines of the invention are designed based on the k27m mutated variant of the human histone 3.
Deutsches Krebsforschungszentrum

Psychotropic agents and uses thereof

Novel amisulpride derivatives and pharmaceutical compositions thereof are disclosed. The amisulpride derivative disclosed herein or a pharmaceutical composition thereof may have better membrane permeability compared to amisulpride.
Lb Pharmaceuticals Inc.

Methods, devices and technology frameworks configured to enable real-time monitoring of head impact data for participants in contact sports

Technology disclosed herein relates to monitoring of effects relevant to head impacts and/or injuries in humans. Embodiments of the invention have been particularly developed for enabling real-time monitoring of head impact data for participants in contact sports systems.
Impact Technologies Australia Pty Ltd

Histotripsy therapy the treatment of brain tissue

A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter.
The Regents Of The University Of Michigan

Enhanced spatial summation for deep-brain transcranial magnetic stimulation

Methods of stimulating a target deep brain region using multiple transcranial magnetic stimulation (tms) electromagnets positioned over a predetermined cortical regions each having a first-order connection to a target deep brain region and applying tms so that the applied tms induces spatial summation and thereby modulation of the target deep brain region.. .

Device for deep electrical and optical brain stimulation

A transmitter housing capable of being connected to the waveguide (50) for the injection of a predetermined wavelength.. .

Electric stimulator

An electric stimulator that effectively improves the brain function of patients suffering from brain disorders by applying electric stimulation to the brain of the patient effectively. The electric stimulator can include main electrodes h to be stuck to particular sites of the patient's body extending from the neck part to the head tip part.
Nihon Medix Co., Ltd.

Devices, monitoring brain activity and for enabling brain to rebalance

Exposure to stressors may be associated with the production of asymmetry in brain waves and can significantly affect a person's overall degree of wellbeing and conversely, asymmetry may influence a person's experience of stress. Through devices and methods that simultaneously look for asymmetries and in real time, one can create real time variable sequences of acoustical stimuli, and then one can effectively and efficiently support the brain to balance its activity between corresponding right and left lobes without one's mindful attention.
Brain State Technologies, Llc

Dna vaccine against amyloid-beta and tau

An object of the present invention is to provide a vaccine that can simultaneously reduce aβ deposition and tau deposition in the brain by means of a single molecule. The present invention provides a recombinant vector comprising dna encoding amyloid-β, dna encoding an immunoglobulin fc sequence, and dna encoding tau..
Immunotherapy Development Inc.

Organic compositions to treat kras-related diseases

The present disclosure relates to rnai agents useful in methods of treating kras-related diseases such as a proliferative disease, including without limitation a solid or liquid cancer, adenocarcinoma, colorectal cancer, advanced and/or metastatic colorectal cancer, colon cancer, lung, non-small cell lung cancer and lung adenocarcinoma, acute myelogenous lung, bladder, brain, breast, cervical, endometrial, gastric, head and neck, kidney, leukemia, myelodysplastic syndrome, myeloid leukemia, liver, melanoma, ovarian, pancreatic, prostate, testicular, thyroid cancers, and cardio-facio-cutaneous (cfc) syndrome and noonan syndrome, and similar and related diseases, using a therapeutically effective amount of a rnai agent to kras.. .
Arrowhead Pharmaceuticals, Inc.

Fused bicyclic pyrimidine derivatives and uses thereof

The present invention provides novel compounds of formula (i), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., lung cancer, breast cancer, leukemia, lymphoma, melanoma, multiple myeloma, ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject.
Dana-farber Cancer Institute, Inc.

New use of inhibitor of cystine-glutamate transporter

The invention surprisingly found that agents that inhibit system xc− provide the therapeutic intervention in substance-related and addictive disorders and the treatment and/or prevention in substance-mediated brain damage and confirms that system xc− is a promising therapeutic target for substance-induced addiction and brain damage.. .
China Medical University

Multi-drug combinations that act as potent radiosensitizers

Provided is a method of treatment including administering to lung, brain or esophageal cancer cells an effective amount of radiation in conjunction with a micelle composition that includes an effective amount of paclitaxel, and one or both of 17-aag, and rapamycin, wherein the micelle includes poly(ethylene glycol)-block-poly(lactic acid) (peg-b-pla).. .
Wisconsin Alumni Research Foundation

Method and device for non-invasive anatomical and systemic cooling and neuroprotection

The present invention provides a method and device for non-invasive anatomical and systemic cooling, fluid removal and/or energy removal. The method and device provide for removal of fluid and cooling of various bodily fluid-containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a coolant into or upon the mucus-containing space or surface.
The Johns Hopkins University

Contingent acquisition and analysis of biological signal or feature thereof for epileptic event detection

We report a method comprising receiving a first indication to gather a first biological signal or feature thereof from a patient; gathering the first biological signal or feature thereof; receiving a second indication to stop gathering the first biological signal or feature thereof, wherein the second indication relates to a detection of an end of a brain state change; and stopping gathering the first biological signal or feature thereof. We also report a medical device system configured to implement the method.
Flint Hills Scientific, L.l.c.

Apparatus and measuring biologic parameters

Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body.
Geelux Holdings, Ltd.

Insertion of medical devices through non-orthogonal and orthogonal trajectories within the cranium and methods of using

An elongated device adapted for insertion, including self-insertion, through the body, especially the skull is disclosed. The device has at least one effector or sensor and is configured to permit implantation of multiple functional components through a single entry site into the skull by directing the components at different angles.

Methods, systems, and devices for imaging microscopic tumors

The disclosed apparatus, systems and methods relate to interventional magnetic resonance imaging (imri). More specifically, clinical applications of the disclosed include magnetic resonance (mr) guided procedures such as endovascular interventions, percutaneous biopsies or deep brain stimulation.
Regents Of The University Of California

Football helmet liner to reduce concussions and traumatic brain injuries

A composite multi-axial impact protection liner for a helmet is provided that reduces rotational acceleration, rotational strain rate, and rotational strain that cause concussions. In a protective helmet so equipped, one or more layers of fluid polymer, including strain thinning and strain thickening polymers, are positioned between the wearer's head and a hard helmet shell.
Zymplr Lc

Composition for preventing and treating degenerative brain disease using novel lactic acid bacteria

Provided is a composition containing lactobacillus reuteri elf corresponding to a novel lactic acid bacteria strain and 5-aminolevulinic acid. The composition may be significantly effective to prevent and treat degenerative brain disease and have excellent anti-obesity and anti-diabetes effects, such that the present invention may provide various pharmaceutical composition, health foods, and the like, using the same..
Wedea Inc.

Etching composition and fabricating semiconductor device by using the same

An etching composition selectively removes a titanium nitride film from a stacked conductive film structure including a titanium nitride (tin) film and a tantalum nitride (tan) film. The etching composition configured to etch titanium nitride (tin) includes 5 wt % to 30 wt % of hydrogen peroxide, 15 wt % to 50 wt % of acid compound, and 0.001 wt % to 5 wt % of corrosion inhibitor, with respect to a total weight of the etching composition, wherein the acid compound includes at least one of phosphoric acid (h3po4), nitric acid (hno3), hydrochloric acid (hcl), hydroiodic acid (hi), hydrobromic acid (hbr), perchloric acid (hno4), silicic acid (h2sio3), boric acid (h3bo3), acetic acid (ch3cooh), propionic acid (c2h5cooh), lactic acid (ch3ch(oh)cooh), and glycolic acid (hoch2cooh)..
Soulbrain Co., Ltd.

T cell receptor-like antibodies specific for a prame peptide

The presently disclosed subject matter provides antigen-binding proteins that specifically bind to preferentially expressed antigen of melanoma (prame), including humanized, chimeric and fully human antibodies against prame, antibody fragments (e.g., scfv, fab and f(ab)2), chimeric antigen receptors (cars), fusion proteins, and conjugates thereof. The antigen-binding proteins and antibodies bind to a prame peptide/hla class i molecule complex.
Eureka Therapeutics, Inc.

Novel compounds as rearranged during transfection (ret) inhibitors

This invention relates to novel compounds which are inhibitors of the rearranged during transfection (ret) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to ret dysfunction or where modulation of ret activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (ibs) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, von hippel-lindau syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased ret kinase activity.. .
Glaxosmithkline Intellectual Property Development Limited

Use of 4-aminopyridine to improve neuro-cognitive and/or neuro-psychiatric impairment in patients with demyelinating and other nervous system conditions

Disclosed herein are methods and compositions related to use of aminopyridines, such as 4-aminopyridine, to improve the neuro-cognitive impairments and related neuro-psychiatric impairments of patients with a demyelinating condition such as ms, traumatic brain injury, cerebral palsy, post-radiation encephalopathy.. .
Acorda Therapeutics, Inc.

Compositions for mitigating head trauma

A method for mitigating the effects of traumatic brain injury in an individual comprising is disclosed. The method includes administering an amount of a composition prior to a period wherein the traumatic brain injury is expected to occur, wherein the composition is comprised of: 300 mg and 500 milligrams (mg) of docosahexaenoic acid (dha), 50 mg/kg to 400 mg/kg (milligrams of composition per kilogram of body weight of the individual) of curcumin, and 10 mg to 100 mg of resveratrol.

System for supporting an elderly, frail and/or diseased person

The present invention relates to a system (10) for supporting an elderly, frail and/or diseased person (12), in particular a person suffering from parkinson's disease, wherein the system (10) comprises: a detection unit (14) including (i) a brain activity sensor (20) for detecting a brain activity signal relating to the brain activity of the person (12) and (ii) a motion detection unit (22) for detecting a motion signal relating to a motion of one or more body parts of the person (12); an analysis unit (16) for determining, based on the detected brain activity signal and motion signal, an activity level of the person (12) which is indicative of the motoric and cognitive activity of the person (12); and a feedback unit (18) for providing a feedback to the person (12) if the activity level of the person (12) exceeds a predetermined threshold.. .
Koninklijke Philips N.v.

Acceleration measurements for impact evaluation

The present invention comprises apparatuses and methods of detecting impacts to the head. Accelerometers attached to a user's head and neck or body is used to measure the differential acceleration of the head with respect to the neck or body.
Board Of Regents, The University Of Texas System

Systems and methods for analyzing electrophysiological data from patients undergoing medical treatments

Systems and methods for analyzing electrophysiological signals acquired from a subject are provided. In some aspects, a method includes receiving electrophysiological signals acquired from a subject using one or more sensors, and assembling a set of time-series data using the acquired electrophysiological signals.
The General Hospital Corporation

Soulbrain Co., Ltd.

. .

Systems and methods for automated detection in magnetic resonance images

Some aspects include a method of determining change in size of an abnormality in a brain of a patient positioned within a low-field magnetic resonance imaging (mri) device. The method comprises, while the patient remains positioned within the low-field mri device, acquiring first and second magnetic resonance (mr) image data of the patient's brain; providing the first and second mr image data as input to a trained statistical classifier to obtain corresponding first and second output; identifying, using the first output, at least one initial value of at least one feature indicative of a size of the abnormality; identifying, using the second output, at least one updated value of the at least one feature; determining the change in the size of the abnormality using the at least one initial value of the at least one feature and the at least one updated value of the at least one feature..
Hyperfine Research, Inc.

Medical imaging

The present invention relates to methods of assessing or obtaining an indication of the presence of a cognitive disorder by analysing microstructural changes in regions of the brain. The invention particularly relates to methods of assessing or obtaining an indication of the presence of types of dementia, for example alzheimer's disease, by analysing changes in minicolumns in regions or layers of the cortex of the brain or of the whole brain..
Isis Innovation Limited

Systems and methods for automated detection in magnetic resonance images

Some aspects include a method of detecting change in degree of midline shift in a brain of a patient. The method comprises, while the patient remains positioned within the low-field magnetic resonance imaging device, acquiring first magnetic resonance (mr) image data and second mr image data of the patient's brain; providing the first and second mr data as input to a trained statistical classifier to obtain corresponding first and second output, identifying, from the first output, at least one initial location of at least one landmark associated with at least one midline structure of the patient's brain; identifying, from the second output, at least one updated location of the at least one landmark; and determining a degree of change in the midline shift using the at least one initial location of the at least one landmark and the at least one updated location of the at least one landmark..
Hyperfine Research, Inc.

Methods of identifying glioblastoma patients as susceptible to anti-angiogenic therapy using quantitative imaging features and molecular profiling

The present invention provides methods to predict the treatment response of brain tumors such as glioblastoma multiforme to anti-angiogenic therapy based on quantitative perfusion-weighted mri that can optionally be combined with intra-tumor specific molecular profiling. Since only a subset of brain cancer patients will benefit from anti-angiogenic therapy, identification of this subset is critical so that the effectiveness of the patient's current anti-cancer treatment regimen and the patient's survival likelihood can be increased by the inclusion of an anti-angiogenic agent..
The Board Of Trustees Of The Leland Stanford Junior University

Generation of neural stem cells and motor neurons

A method of generating a population of cells useful for treating a brain disorder in a subject is disclosed. The method comprises contacting mesenchymal stem cells (mscs) with at least one exogenous mirna having a nucleic acid sequence at least 90% identical to a sequence selected from the group consisting of seq id nos: 15-19 and 27-35, thereby generating a population of cells and/or generating neurotrophic factors that may provide important signals to damaged tissues or locally residing stem cells.
Exostem Biotec Ltd.

19-nor c3, 3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof

And pharmaceutically acceptable salts thereof; wherein , r1, r2, r3a, r3b, r4a, and r4b are as defined herein, and a is a carbon bound substituted or unsubstituted 5- to 6-membered heteroaryl ring as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus..

Functionalised benzopyran compounds and use thereof

Benzopyran compounds, the preparation thereof, and their use in methods for treating cancer and reducing the incidence or risk of cancer recurrence. The cancer can be one or more of pancreatic cancer, colorectal cancer, melanoma, prostate cancer, brain cancer (including paediatric and adult), ovarian cancer, breast cancer, lung cancer, liver cancer, uterine cancer, neuroblastoma, mesothelioma, malignant ascites or peritoneal cancer..
Novogen Limited

Quinoline derivatives for diagnosis and treatment of alzheimer's disease

A new class of quinoline compounds is useful for the detection and treatment of alzheimer's disease and other neurodegenerative diseases such as amyloidoses and tauopathies. The compounds can be synthesized in radiolabeled form for use as imaging agents, which can be used for early detection of aggregates in the brain or other tissues prior to onset of symptoms, allowing early therapeutic intervention.
Northeastern University

Novel azetidine derivatives useful as modulators of cortical cathecolaminergic neurotransmission

The present disclosure relates to certain novel compounds of formula (i) and to their utility in modulation of levels of monoamines, dopamine, norepinephrine and serotonin, in cerebral cortical areas of the mammalian brain, and more specifically for the treatment of central nervous system disorders.. .
Integrative Research Laboratories Sweden Ab

Systems and methods for modulation and mapping of brain tissue using an ultrasound assembly

Methods and systems for modulation and mapping of brain tissue in a subject using an ultrasound assembly are provided. An exemplary method for modulation uses an ultrasound assembly including a housing and an ultrasound transducer joined to the housing.
The Trustees Of Columbia University In The City Of New York

Catheter assemblies

A catheter assembly for transferring fluid into and out of a ventricle in the brain is disclosed. The catheter assembly include a sheath permanently installed in the brain, a catheter removably disposed in the sheath, and a connector.
University Of Massachusetts

Hyaluronic acid derivative and neural stem cells for sci and pnt regeneration

B) contacting isolated neuronal stem cells with the hyaluronic acid derivative obtained from step a) and culturing and expanding the absorbed cells in the presence of growth or neurotrophic factors selected from βfgf (basic fibroblast growth factor), cntf (ciliary neurotrophic factor), bdnf (brain derived neurotrophic factor) and gdnf (glial derived neurotrophic factor) or mixtures thereof.. .

Humanized antibodies

The invention relates to humanized antibodies that bind to an epitope at the n-terminus of pyroglutamated amyloid beta (aβ n3pe) peptide and to preventive and therapeutic treatment of diseases and conditions that are related to accumulation and deposition of amyloid peptides, such as amyloidosis, a group of disorders and abnormalities associated with pyroglutamated amyloid peptide, like alzheimer's disease, down's syndrome, cerebral amyloid angiopathy and other related aspects. More specifically, it pertains to the use of humanized monoclonal antibodies to bind pyroglutamated amyloid beta peptide in plasma, brain, and cerebrospinal fluid to prevent accumulation or to reverse deposition of aβ n3pe within the brain and in various tissues in the periphery, and to alleviate amyloidosis.
Probiodrug Ag

Metabolic therapy for oxidative stress in the brain through targeted neuronal catabolism of n-acetyl-aspartic acid

The present invention provides a novel method of treatment for treating brain disorders that manifest oxidative stress by providing targeted populations of neurons with the ability to catabolize the acetylated amino acid derivative, n-acetylaspatic acid (naa) and further supply extraphysiological levels of atp to neurons via the targeted expression of the naa catabolic enzyme aspartoacylase (aspa) in neurons and astrocytes.. .
Rowan University

Process for preparing an animal brain extract

The present invention refers to a process for preparing an animal brain extract. It also refers to the brain extract obtainable according to said process and to the use thereof as a medicine, in particular for the prevention and/or treatment of neurodegenerative diseases and disorders of the central nervous system.
Bioiberica, S.a.

Biomolecules involved in alzheimer's disease

The invention relates to panels of biomarkers including proteins phosphatase 1 regulatory subunit 14a and/or 2′,3′-cyclic-nucleotide 3′-phosphodiesterase and/or phosphorylated tau or fragments thereof and methods using thereof for diagnosing, staging, treating and assessing the response of a treatment for a neurocognitive disorder characterised by tau toxicity, in particular for alzheimer's disease. The present invention shows that the biomarkers disclosed herein are elevated in the brain of subjects with an advanced stage of a neurocognitive disorder (braak stage v/vi) and/or are regulated in the csf of ad subjects in comparison to cognitively affected non-ad controls; and/or regulated in response to two casein kinase 1 delta inhibitors..
Electrophoretics Limited

Method of treating or inhibiting the development of brain inflammation and sepsis

A leukotriene c4 and d4 antagonist is used to treat or inhibit brain inflammation and sepsis by acting to inhibit increased capillary permeability and white blood cell extravasation. Potential candidate compounds can be screened in a non-human mammal before or after administration of an inflammation inducing agent into the subarachnoid space by determining their ability to inhibit increased capillary permeability and white blood cell extravasation..
Inflammation Research Center Company Ltd.

Use of dianhydrogalactitol and analogs or derivatives thereof in combination with platinum-containing antineoplastic agents to treat non-small-cell carcinoma of the lung and brain metastases

The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of non-small-cell lung carcinoma (nsclc) and ovarian cancer, as well as other types of malignancy, including brain metastases of nsclc. Dianhydrogalactitol acts as an alkylating agent on dna that creates n7 methylation.
Delmar Pharmaceuticals, Inc.

Brain wave processing for diagnosis of a subject

Embodiments relate to digital image processing for diagnosis of a subject. More specifically, the embodiments relate to automation of diagnoses through data interpretation.
International Business Machines Corporation

Feedback brain stimulation to enhance sleep spindles, modulate memory and cognitive function, and treat psychiatric and neurological symptoms

The present invention relates to methods for modulating bursts of oscillatory brain activity, such as sleep spindles, in a subject. The invention further relates to methods of improving memory or cognitive function in a subject and method of modulating or enhancing the frequency of occurrence, structure, amplitude, and/or synchronization of sleep spindles in a subject by detecting a burst of oscillatory brain activity in the subject and passing an oscillating current through the skull of the subject..
The University Of North Carolina A! Chapel Hill

System and attention management

The present invention discloses a system and method for attention management, adapted for managing an attention of a transport driver driving a car, and the attention management method comprises the following steps: providing a detection device to configured at the transport driver's forehead to detect a brain wave of the transport driver; using a brain wave algorithm to analyze the brain wave in order to obtain a brain wave analyzed information; determining that the brain wave analyzed information matches an attention deficiency condition or not; and making a warning sound and transmitting a warning message to a remote dispatching center if the brain wave analyzed information matches the attention deficiency condition.. .
Inventec Corporation

Apparatus and measuring biologic parameters

Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body.
Geelux Holdings, Ltd.

Systems and methods for monitoring of blood lactate and targeting of blood lactate via nutritional support

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“bes”) of a patient, are disclosed. The bes provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient.
Run Them Sweet Llc

Device and providing notification message about call request

Provided are an artificial intelligence system for simulating functions and so forth of human brains by using a mechanical learning algorithm. A method, performed by a device, of providing a notification message about a call request may include one or more of receiving the call request from another device, obtaining context information about a situation of a user if a user input accepting the call request is not received within a preset time, determining a reason for a non-response of the user by analyzing the context information, obtaining information about a relationship between the user and another user of the other device, generating a notification message describing the reason for the non-response based on the context information, determining whether to transmit the notification message to the other device based on the reason for the non-response and the information about the relationship, and transmitting the notification message to the other device based on the determination..
Samsung Electronics Co., Ltd.

Inter-patient brain registration

An inter-patient brain registration method for data normalization deformably aligns two brain images obtained from different patients even with tumor presence.. .
Sony Corporation

Brain tissue classification

A system and method are provided for brain tissue classification, which involves applying an automated tissue classification technique to an image of a brain based on a prior probability map, thereby obtaining a tissue classification map of the brain. A user is enabled to, using a user interaction subsystem, provide user feedback which is indicative of a) an area of misclassification in the tissue classification map and b) a correction of the misclassification.
Koninklijke Philips N.v.

Electroencephalograph-based user interface for virtual and augmented reality systems

An apparatus to analyze and manipulate biofeedback data is described. The apparatus includes a display that renders a simulated environment.

Method for clinically and pathologically monitoring alzheimer's disease through concentration of amyloidbeta in plasma

Provided is a method for quantifying aβ in plasma by treating the plasma with mpp and/or tcep, and a method for diagnosing, using the quantifying method, whether or not clinical cognitive deterioration and pathological aβ accumulation occur. Through cut-off values of measured values measured by the method for quantifying aβ according to the present subject matter, it is possible to identify normal, mci and ad subjects and determine whether or not accumulation of aβ in the brain occurs, and it is possible to predict progression to ad..
Seoul National University R&db Foundation

Aptamers against glioma cells

Provided are aptamers able to bind to ligands associated with cancer cells. The ligands may particularly be associated with brain cancers, such as gliomas.
University Of Central Lancashire

Electronic device, wearable device, and providing content-based somatic senses using ultrasound

Provided is an electronic device for providing somatic senses based on content. The electronic device includes: a processor configured to generate an ultrasound driving signal for evoking somatic senses corresponding to somatosensory data by stimulating a certain region of the brain of a user; and a communication interface configured to transmit the generated ultrasound driving signal to an external device, wherein the somatosensory data corresponds to the content..
Samsung Electronics Co., Ltd.

Brain penetrant amylin receptor based peptides for alzheimer's disease

Amylin receptor antagonists capable of binding to the amylin receptor and inhibiting activity of amylin or amyloid-beta protein are provided. The amylin receptor antagonists can be administered in the form of pharmaceutical compositions or the like.
The Governors Of The University Of Alberta

Novel kcnq potassium channel agonist, and preparation method therefor and use thereof

The present invention provides a compound represented by general formula i or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with rtg.
Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences

Brain neurostimulator electrode fitting

Fitting a brain neurostimulator electrode array comprises positioning at least a first electrode in a desired target structure in a first cerebral hemisphere, and positioning at least a second electrode in a corresponding target structure in a contralateral cerebral hemisphere. Electrical stimuli are applied from the first electrode to the desired target structure.
Saluda Medical Pty Ltd

Biopolymer system for tissue sealing

A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed.
Endomedix, Inc.

Use of botanical extracts for improving brain health through enhanced neurogenesis

The present invention relates generally to a method for improving brain health by orally administering a botanical extract composition in an amount effective to promote the neurogenesis process. More particularly, the present invention relates to using spearmint (mentha spicata l.) extracts in order to increase the rate of neurogenesis..
Kemin Industries, Inc.

Methods of treating neurodegenerative disorders

A method of treating a mammal with one of a central nervous system injury and a neurodegenerative disorder comprising isolating, culturing, and generating neural progenitor cells from a mammalian placenta, and transplanting the placenta derived neural progenitor cells into a brain of the mammal.. .
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College

Device for brain biopsy

Various devices and methods for guiding a biopsy surgical tool are disclosed. One type of surgical device includes a first rotational mechanism, a translational mechanism, and a second rotational mechanism.
Parseh Intelligent Surgical System

Automatic evaluating and treating visual health

A system and method is useful for treating amblyopia and other conditions by visual stimulation of the brain. Automatic discrimination between a pair or more of similar body organs, such as the eyes is accomplished for improved safety and efficacy of a treatment.
Medisim, Ltd.

Monitoring brain neural activity

Monitoring brain neural activity comprises repeatedly applying electrical stimuli to evoke neural responses in the brain. Neural responses evoked by the stimuli are recorded.
Saluda Medical Pty Ltd

Apparatus and measuring brain processing speed

The present invention is directed to an apparatus for identifying the rate of frequency at which a person perceives distinct visual images or sounds. The device, product and method comprise means for presenting the image(s) or sounds, means for selecting the distinct image(s) or sounds, means for selecting an instance number, presenting the image or sound in an amount equal to the instance number, the distinct image being displayed on a screen, the sound being presented via a speaker, at a first frequency rate at which frequency the person in unable to perceive the correct number of images or sounds, means for decreasing the frequency rate presentation of the distinct image or sound to a second frequency rate, the second frequency rate being the frequency at which the person is able to perceive individual occurrences of the image or sound in an amount equal to the instance number, and capturing the value of the second display frequency.
Infinite Mind, Lc

Shikuukankoubou Co.,ltd.

. .

Content management system using sources of experience data and modules for quantification and visualization

A semantic note taking system and method for collecting information, enriching the information, and binding the information to services is provided. User-created notes are enriched with labels, context traits, and relevant data to minimize friction in the note-taking process.
Apple Inc.

Next gen sdn with smart agent based routing (sabr)

A multi-tier solution has been disclosed which in one embodiment provides an easy way to transfer a running application from one device to another. In this embodiment, this innovative approach introduces new multi-tiers application structure which consists of face, brain and body segments, and provides users with different means of application transfer based on their needs..

Biomarkers of traumatic brain injury

Provided is a method of diagnosing and/or monitoring mild traumatic brain injury (mtbi) or concussion in a subject. The method comprises determining a level of at least one mirna in a saliva sample from the subject.
The University Of Birmingham

Pro-neurogenic compounds

This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein.
Board Of Regents Of The Univeristy Of Texas System

Systems and methods for modulating the electrical activity of a brain using neuro-eeg synchronization therapy

Described are methods, devices, and systems for a novel, inexpensive, easy to use therapy for treatment of coma, post-traumatic stress disorder, parkinson's disease, cognitive performance, and/or amblyopia. Described are methods and devices to treat coma, post-traumatic stress disorder, parkinson's disease, cognitive performance, and/or amblyopia that involves no medication.
Neosync, Inc.

Systems and methods for functional restoration and rehabilitation of posture, gait and movement

A wearable electrical stimulation system for improving a motor function of a patient after the patient has a stroke. The system is deployed by positioning one stimulation unit on the head patient in electrical communication with a first portion of the patient's brain, positioning a second stimulation unit on a region of the patient comprising muscles requiring motor function improvement, and using a controller to activate the first stimulation unit and second stimulation unit.
Lyriq, Llc

Compositions for enhancing delivery of agents across the blood brain barrier and methods of use thereof

Compositions and methods for improved delivery of active agents to the brain are provided. The compositions typically include a nanocarrier, such as a polymeric nanoparticle, liposome, or nanolipagel or are in the form of a conjugate.
Yale University

Induced expression of brain derived neurotrophic factor (bdnf) for treatment of neuromuscular, neurodegenerative, autoimmune, developmental and/or metabolic diseases

A method of treating a host of neuromuscular, neurodegenerative, developmental, autoimmune and metabolic diseases/disorders related to aging, such as traumatic injury, stroke, huntington's disease, epilepsy, multiple sclerosis (ms), lupus, type-1 and type-2 diabetes, maturity onset diabetes of the young (mody), myasthenia gravis (mg), rheumatoid arthritis (ra), graves' disease, guillain-barré syndrome (gb s), metabolic syndrome, muscular dystrophy or duchenne muscular dystrophy (dmd), severe burns, aging, amyotrophic lateral sclerosis (als), friedreich's ataxia, batten disease, alzheimer's disease, optic neuritis, leber's hereditary optic neuropathy (lhon), autism, rett syndrome, batten disease, angelman's syndrome, leigh disease, fragile-x syndrome, depression, parkinson's disease, mitochondrial diseases, developmental disorders, metabolic disease disorders and/or autoimmune disorders by inducing endogenous bdnf expression with dnp treatment to protect from neuromuscular dysfunction/disorders and/or neurodegeneration and/or muscle wasting. Dnp was administered to mice daily over a range of doses, and subsequently bdnf expression in the brain showed a dose dependent and non-linear increase in expression..
Mitochon Pharmaceuticals, Inc.

Automatic brain probe guidance system

The disclosure relates to an automatic brain-probe guidance systems. Specifically, the disclosure is directed to a real-time method and system for guiding a probe to the dorsolateral oscillatory region of the subthalamic nucleus in the brain of a subject in need thereof using factored partially observable markov decision process (pomdp) via hidden markov model (hmm) represented as a dynamic bayesian network (dbn)..
Alpha Omega Neuro Technologies Ltd.

Brainwave sensor unit and brainwave measurement device using same

Disclosed are a brainwave sensor unit and a brainwave measurement apparatus using the same. The brainwave sensor unit includes first and second contact electrodes located on a supporter, the first contact electrode obtains a brainwave signal from a living body, and the second contact electrode is spaced apart and electrically insulated from the first contact electrode and is grounded..
Samsung Electronics Co., Ltd.

Taxane analogs for the treatment of brain cancer

Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at g2-m interface during mitosis but is not a substrate for mdr protein. In particular, the present application relates to the use of an orally effective abeo-taxane, alone or in combination with temozolomide or bevacizumab, for the treatment of brain cancer..
Longwood Gardens, Inc.

Mapc treatment of brain injuries and diseases

The invention relates to the treatment of various injuries, disorders, dysfunctions, diseases, and the like of the brain with mapcs, particularly in some aspects, to the treatment of the same resulting from hypoxia, including that caused by systemic hypoxia and that caused by insufficient blood supply. In some further particulars the invention relates, for example, to the treatment of hypoxic ischemic brain injury with mapcs, in children for example, and to the treatment of cortical infarcts and stroke with mapcs in adults, for example..
Longwood Gardens, Inc.

Medical image processing apparatus and medical image processing method

A medical image processing apparatus according to an embodiment includes processing circuitry configured to: extract position information of innervation from subject data; convert a subject nerve region that is based on the extracted position information into atlas data; analyze a position relation between a functional area in a brain in the atlas data and the converted subject nerve region; and convert the analysis result into the subject data.. .
Toshiba Medical Systems Corporation

Internal device of brain-machine interface system including noise reduction technique, and controlling the internal device

An internal device of a brain-machine interface system includes: an electrode group including n electrodes, n being 2 or more; an amplification element group including n amplification elements; a communicator communicating with an external device; and a controller selectively executing one of: a normal operation mode in which electroencephalogram signals acquired through the n electrodes are supplied to the amplification element group in a manner that each of the n electrodes corresponds to a respective one of the n amplification elements, and n amplified electroencephalogram signals are transmitted; and a noise-reduction operation mode in which an electroencephalogram signal acquired through an m electrode of the electrode group is supplied to the amplification element group in a manner that each m electrode corresponds to respective plural ones of the amplification elements, and an m amplified electroencephalogram signal is transmitted, m being smaller than n.. .
National Institute Of Information And Communicatio Ns Technology

Prognostic and diagnostic glycan-based biomarkers of brain damage

The present disclosure relates to glycan-based biomarkers for the diagnosis or prognosis of brain damage, such as traumatic brain injury (tbi).. .
Medicortex Finland Oy

Device for online measurement of neurotransmitters using enzymatic reactors

The invention relates to a device and a method for measuring neurotransmitters in the brain dialysate of mammals using enzymatic reactors specific to a certain neurotransmitter, which generate fluorescent derivatives when mixed. The mixture is introduced into an incubation chamber and passes through a temperature controlling system in order to set it to the optimum enzymatic reaction temperature, and the fluorescent derivative generated is passed through a flow fluorescence cell located inside the incubation chamber, where the liquid is impacted with a laser light source via an optical fiber.

Methods of maintaining, expanding, and differentiating neuronal subtype specific progenitors

Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors..
Wisconsin Alumni Research Foundation

Compositions and methods for the treatment of carboxyhemoglobinemia

Described herein is a new antidote for the rapid elimination of carbon monoxide from hemoglobin, including brain, heart, and red cell hemoglobin. The disclosed therapy involves the use of modified human globins, particularly neuroglobins modified at residue 64 and cytoglobins modified at residue 81, which bind carbon monoxide with extremely high affinity.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education

Treating degenerative dementia with low intensity focused ultrasound pulsation (lifup) device

Ultrasonic energy is used for treating degenerative dementia. A focal point of an ultrasonic transducer beam is directed at a target area of the brain to promote removal of substances that accumulate in the interstitial pathways that are at least partially responsible for the degenerative dementia.
Brainsonix Corporation

Quadruple butterfly coil

Provided herein are embodiments of a quadruple butterfly coil (qbc) configuration having enhanced focality for stimulation of specific areas of a brain for therapeutic treatment. Finite element simulations were conducted for the qbc, the qbc with a single shield, and the qbc with a double shield.
Iowa State University Research Foundation, Inc.

System and neuromorphic controlled adaptive pacing of respiratory muscles and nerves

Adaptive systems and methods for automatically determining and continuously updating stimulation parameters for adjusting ventilation to accommodate a patient's specific physiology, metabolic needs, and muscle state are disclosed herein. Having a closed loop implementation, the system may comprise a controller including a neuromorphic controlled adaptive feed-forward pattern generator/pattern shaper (pg/ps) assembly, which controls respiratory muscle movement using electrical stimulation.
The Florida International University Board Of Trustees

Minimally invasive subgaleal extra-cranial electroencephalography eeg monitoring device

A system includes an implantable body configured for implantation in a subgaleal extracranial position, the implantable body including a first electrode array including a first elongated body comprising first and second electrode contacts separated from one another by a distance selected to facilitate the detection of brain electrical activity and a unit coupled to the first electrode array. The unit includes a processor analyzing the detected brain electrical activity to determine whether an epileptic event has occurred and generating epileptic event data based on this determination and a transceiver controlled by the processor to wirelessly transmit epileptic event data to and from a remote computing device..
New York University

Hearing prosthesis emitting ultrasonic pulses

The invention relates to a hearing prosthesis having at least one acoustic converter for converting acoustic signals into electrical signals, and comprising an ultrasound device by means of which a multiplicity of focused, pulsed ultrasonic beams can be generated, wherein the ultrasound device can be fixed in the outer ear and/or outside the ear, and wherein, on the basis of electrical signals generated by the acoustic converter, the ultrasonic beams can be focused on to various physically distributed points in a region of the inner ear or in a region of the auditory pathway in the brain, while stimulating nerves.. .
Audisense Gmbh

Activation map based individualized planning for deep brain stimulation

Example apparatus and methods plan and control neuro-modulation of a distributed multi-region network in a brain. A location for a deep brain stimulation (dbs) electrode that participates in activating a combination of white matter pathways associated with the network is selected.
Case Western Reserve University

Conformal electrode arrays for electrophysiologic recording and neural stimulation within the cerebral ventricles

The present disclosure relates to an array of electrodes on a flexible scaffolding, with the ability to collapse into an axial configuration suitable for deploying through a narrow cylindrical channel. The electrode arrays can be placed into the ventricular system of the brain, constituting a minimally invasive platform for precise spatial and temporal localization of electrical activity within the brain, and precise electrical stimulation of brain tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain..
Precision Neurotechnologies Llc

Electrode and electrode pad for the electrical stimulation of brain tissue or other tissue of a patient

An electrode for the electrical stimulation of brain tissue or other tissue of a patient is configured for location between skull and scalp of the patient. The electrode has a stimulation surface which is configured for contacting the skull of the patient.
Precisis Ag

Perfusive organ hemostasis

Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in nephron-sparing surgeries, which produces a completely bloodless surgical field, allowing speedy resection. In certain embodiments, after a certain amount of time, the flow gradually resumes, with no apparent adverse consequences to the kidney.
Genzyme Corporation

Egfr-directed car therapy for glioblastoma

Glioblastoma (gb) remains the most aggressive primary brain malignancy; brain metastasis, such as breast cancer brain metastases (bcbms), are also aggressive and are associated with poor prognosis. Adoptive transfer of chimeric antigen receptor (car)-modified immune cells has emerged as a promising anti-cancer approach, yet the potential utility of car-engineered cells to treat brain cancers has not been explored.
Ohio State Innovation Foundation

Method to improve neurologic outcomes in temperature managed patients

A method of improving brain function in a hypothermic patient is provided. The method comprises administering to the patient an amount of a fibroblast growth factor 21 (fgf21) effective to increase rna binding motif 3 (rbm3) production in nerve cells of the patient.
University Of Pittsburgh-of The Commonwealth System Of Higher Education

Amidated dopamine neuron stimulating peptide restoration of mitochondrial activity

The present invention relates to the use of novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (gdnf) peptides (or “amidated dopamine neuron stimulating peptides (adns peptides)”), for treating brain diseases and injuries that result in dopaminergic deficiencies and mitochodrial dysfunction, e.g., reduced complex i enzyme activity.. .
University Of Kentucky Research Foundation

Composition for promoting production of brain-derived neurotrophic factor

An object of the present invention is to provide novel composition and agent for promoting the production of a brain-derived neurotrophic factor (bdnf) and a novel method for promoting the production of bdnf. The present invention provides a composition for promoting the production of bdnf and an agent for promoting the production of bdnf, each comprising cacao polyphenols.
Meiji Co., Ltd.

Non-peptidic gapdh aggregation inhibitor

[problem] provided is a non-peptide compound, which can be used as a gapdh aggregation inhibitor, [solution] provided is a gapdh aggregation inhibitor including as an active ingredient a compound represented by the chemical formula 1 wherein r1, r2, and r3 are each independently a hydrogen atom, a halogen atom, or an aliphatic hydrocarbon group having a carbon number of from 1 to 10, a polysulfurized derivative thereof, or a pharmaceutically acceptable salt thereof. The present compound has a gapdh aggregation inhibitory activity to suppress intracerebral aggregation of various proteins involved in cerebral neurodegenerative diseases, thereby contributing to improvement in various brain neurological diseases associated with aggregation of these proteins such as alzheimer's disease, parkinson's disease, and cerebral infarction, and prevention of advanced seriousness of these diseases..
Osaka Prefecture University Public Corporation

Nanocarrier therapy for treating invasive tumors

Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the invasiveness of the tumors, and inhibits tumor metastasis.
Children's Healthcare Of Atlanta, Inc.

System for characterizing brain condition

A sensitive measure of brain condition simultaneously evaluates multiple measurements of water diffusion in brain tissue combined so as to correct for covariance between the different data types of the multipoint measurements and compares the multipoint measurements to a corresponding multipoint measure representing normal brain tissue to provide a distance indicating a likelihood of atypical brain conditions.. .
Wisconsin Alumni Research Foundation

Wrist rigidity assessment device for use in deep brain stimulation surgery

It is disclosed an articulation rigidity assessment device for assessing the rigidity of the articulation when a bending motion is imposed to a limb of said articulation around a predetermined rotation axis of the articulation, said device comprising: a one-axis angular velocity sensor for attaching to said limb such that the axis of measurement is parallel to the axis of rotation of the imposed bending motion; a data processor configured to process the signal of the angular velocity sensor and to distinguish between non-rigid and rigid states of the articulation using the processed angular velocity signal. The articulation may be the wrist articulation of the patient and the limb is the respective hand.
Inesc Tec - Instituto De Engenharia De Sistemas E Computadores, Tecnologia E CiÊncia

Ocular micro tremor (omt) sensor, system and method

An eye sensor, system and method for measuring fixational eye movements of an individual's eyeball (e.g., ocular microtremors and microsaccades) to provide a variable voltage biosignal for measuring the individual's brain stem activity. The eye sensor comprises a sensor mounted on the individual's closed or opened eyelid so as to be deflected by the fixational eye movements of the eyeball.
Brainstem Biometrics, Inc.

System and brain event capture monitoring and evaluating with respect to accumulated histories

A method for diagnosing and rapidly introducing treatment to a subject suffering visible or non-visible traumatic brain injury is provided. A wearable array of electroencephalography (eeg) sensors in electrical communication with a communications capability to one or more subjects is present.

Brain electrode apparatus, measuring signal outputted from brain nervous tissue, and applying signal to brain nervous tissue

A brain electrode apparatus is a brain electrode apparatus including an electrode that is capable of being inserted into a brain, and the brain electrode apparatus includes a long-shaped probe, an electrode part formed on the probe, and an inserting member that is detachably inserted in a first hole formed on a plane face of the probe having flexibility. Further, the probe includes a first area on the electrode part side with respect to the position where the first hole is formed, and a second area on the opposite side of the electrode part side with respect to the position where the first hole is formed, and the inserting member is inserted into the first hole in a state where the probe is bent at the position of the first hole such that the second area overlaps the first area..
Promoveo Llc

Temporary or long term implantation device for intracranial probes having hematoma detection apparatus, and using device thereof

A biopsy needle surrounded by a peel away sheath chemically impregnated with a blood detection composition enabling a user (e.g., a surgeon) to accurately and timely determine the existence of a blood pooling or hematoma when passing an implantable (e.g., deep brain stimulation probes) or non-implantable (e.g., biopsy needle) device into a region of the subject's body (e.g., a brain) to gather tissue for further analysis. A biopsy needle may be provided wherein the needle is tightly surrounded by a peel-away sheath that is chemically impregnated with a blood detection composition.

System and ocular function tests

A system for use in performing ocular examinations, such as convergence and accommodation useful in diagnosing traumatic brain injury (including concussion), includes an assessment device. The assessment device includes a portable carrier having a visual target and a distance measurement component.
Brainscope Company, Inc.

Rehabilitation system

A rehabilitation system includes: a brain activity measuring device which measures brain activity of a patient who carries out training based on a set amount of training; a motion measuring device which measures a motion state of a paralyzed site of the patient; a spasticity state determiner which determines a spasticity state based on the brain activity and the motion state; an updater which updates the amount of training based on a result of determination by the spasticity state determiner; and a presentation device which presents the updated amount of training to the patient.. .
Seiko Epson Corporation

Automatic detection and identification of brain sulci in mri

Disclosed is a method for determining a position of a brain sulcus in the brain of a patient, the method comprising executing, on at least one processor of at least one computer, steps of: acquiring, at the at least one processor, patient image data describing a digital medical image of at least part of the brain; acquiring, at the at least one processor, atlas data describing an image-based model of the at least part of the brain; determining, by the at least one processor and based on the patient image data and the atlas data, mapping data describing a transformation between the patient image data and the atlas data; and determining, by the at least one processor and based on the patient image data and the atlas data and the mapping data, sulcus position data describing the position of the brain sulcus in the digital medical image.. .
Brainlab Ag

Display control device, control method thereof, and display control system

A display control device, a control method thereof, and a display control system are provided. The display control method includes: acquiring a gaze position on a display image while eyes are gazing at a current display image, and acquiring a current brain wave while the eyes are gazing at the current display image; determining a control instruction corresponding to the current brain wave according to the current brain wave, in condition that a characterized parameter of the current brain wave meets a preset condition; executing an operation corresponding to the control instruction on the display image being gazed.
Boe Technology Group Co., Ltd.

Methods of assessing gfap status in patient samples

Disclosed herein are improved methods of assessing glial fibrillary acidic protein (gfap) status in a subject (such as for examples, as a measure of traumatic brain injury or for other clinical reasons).. .
Abbott Laboratories

Methods of assessing uch-l1 status in patient samples

Disclosed herein are improved methods of assessing ubiquitin carboxy-terminal hydrolase l1 (uch-l1) status in a subject (such as for example, as a measure of traumatic brain injury or for other clinical reasons). Also disclosed herein are methods of assessing a subject's glial fibrillary acid protein (gfap) and uch-l1 status in subject (such as, for example as a measure of traumatic brain injury or for other clinical reasons)..
Abbott Laboratories

Methods of generating oligodendrocytes and cell populations comprising same

A method of generating a population of cells useful for treating a brain disorder in a subject is disclosed. The method comprises contacting mesenchymal stem cells (mscs) with at least one exogenous mirna having a nucleic acid sequence at least 90% identical to a sequence selected from the group consisting of seq id nos: 15-19 and 27-35, thereby generating a population of cells and/or generating neurotrophic factors that may provide important signals to damaged tissues or locally residing stem cells.
Exostem Biotec Ltd.

Method for treatment of depression using synaptic pathway training

Disclosed are methods of treating depression, mania, post-traumatic stress disorder (ptsd), and various other neurologic conditions using synaptic pathway training. Methods of synaptic pathway training include, generally, achieving a favorable treatment result by activating a synaptic pathway using a pharmacologic agent, such as treating refractory symptoms of depression with ketamine, following by potentiation of the favorable result by repeatedly stimulating the activated pathway.

Modified ube3a gene for a gene therapy approach for angelman syndrome

Angelman syndrome (as) is a genetic disorder occurring in approximately one in every 15,000 births. It is characterized by severe mental retardation, seizures, difficulty speaking and ataxia.
University Of South Florida

Pharmaceutical composition for prevention, treatment or delay of alzheimer's disease or dementia containing g protein-coupled receptor 19 agent as active ingredient

The present invention relates to a pharmaceutical composition for preventing, treating or delaying an alzheimer's disease (ad) or dementia including a g protein-coupled receptor19 (gpcr19) agonist or its pharmaceutically acceptable salt as an active ingredient and a food composition for preventing, treating or delaying an alzheimer's disease or dementia. The gpcr19 agonist according to the present invention has an effect of improving cognitive and behavioral disorders without harming the health of objects when administrated to the objects and has an effect of preventing the alzheimer's disease or dementia or delaying or treating the progression of the disease in the objects with the disease by suppressing apoptosis of the brain tissue, enhancing immunity, and reducing formation of an amyloid β (aβ) plague..
Seoul National University R&db Foundation

Amelioration of radiation-induced cognitive dysfunction

Treatment with 2-amino substituted nicotinamides ameliorates the cognitive dysfunction resulting from radiation of the brain.. .
Neuralstem, Inc.

Flexible vascular occluding device

A vascular occluding device for modifying blood flow in a vessel, while maintaining blood flow to the surrounding tissue. The occluding device includes a flexible, easily compressible and bendable occluding device that is particularly suited for treating aneurysms in the brain.
Covidien Lp

Method for positron emission tomography (pet) imaging analysis for classifying and diagnosing of neurological diseases

A method of using pet imaging includes using pet images obtained using a radiotracer for the determination of the progressive course of regional brain pet activities for a progressive neurodegenerative disease (e.g., mci, ad, and cte). The method may be used for the automatic staging of neurodegenerative disease for a particular patient/subject based on regional intensity and spatial patterns of the brain signals measured by pet imaging.
The Regents Of The University Of California

Head-mounted display eeg device

Methods, systems, and devices are disclosed for monitoring electrical signals of the brain. In one aspect, a system for monitoring electrical brain activity associated with visual field of a user includes a sensor unit to acquire electroencephalogram (eeg) signals including a plurality of eeg sensors circumnavigating the head of a user, and a head-mounted frame for docking a personal electronic device over the user's eyes to present visual stimuli, in which the visual stimuli is configured to evoke eeg signals exhibited by the user, in which the assessment indicates if there is a presence of visual field defects in the user's visual field..
Ngoggle

Neurofeedback eyeglasses

Thermal measurements of the forehead can be indicative of brain activity, and as such, may be useful for conducting brain-related treatments, such as neurofeedback. In one embodiment, a system for conducting a neurofeedback session includes an inward-facing head-mounted thermal camera (cam) and a user interface.
Facense Ltd.

Method for sampling cerebral insular cortex activity

Disclosed herein is a technique for observing the insular cortex activity by using electroencephalograms. A method for sampling cerebral insular cortex activity includes: recording electroencephalograms (eegs) provided by a plurality of eeg electrodes; creating a three-dimensional model in the form of a mesh in which a subject's brain is decomposed into a plurality of sites according to the subject's brain structure and positioning the plurality of eeg electrodes by reference to an image representing the subject's brain and head structure; creating a forward model by modeling a correlation between the activities of the respective brain sites of the three-dimensional model and an electroencephalogram distribution of the positioned eeg electrodes; and associating, by reference to information about a region of interest measured by functional magnetic resonance imaging (fmri) and the forward model, data about the electroencephalograms recorded with the cerebral activity of the region of interest..
Hiroshima University

Method and system for incorporating physiological self-regulation challenge into geospatial scenario games and/or simulations

A method of providing physiological self-regulation challenges prior to participating in a series of activities or exercises at a series of predefined locations includes determining a physiological goal associated with each location. A sensing device measures a physiological state of a user, and a mobile communication device communicates to a user whether or not the user has achieved the physiological goal for the challenge.
U.s.a. As Represented By The Administrator Of Nasa

Wireless intracranial monitoring system

Some embodiments of the present disclosure comprise improved systems and methods for monitoring physiological parameters such as intracranial pressure (“icp”), intracranial temperature, and subject head position. For example, in some embodiments, an implantable apparatus for measuring icp can be implanted into a subject skull.
Branchpoint Technologies, Inc.

Flat panel test hardware and technology for assessing ballistic performance of helmet personnel protective equipment

A testing apparatus to assess ballistic performance of helmet personnel protective equipment having a flat helmet analogue with a helmet shell material in flat panel form and at least one helmet suspension pad; head surrogate components including a skull skin surrogate, a skull bone surrogate, and a brain tissue surrogate; a pressure indicating film adjacent to the head surrogate components; and one or more pressure sensors in the brain tissue surrogate. Also disclosed is the related method for assessing ballistic performance of helmet personnel protective equipment..
The Government Of The United States Of America, As Represented By The Secretary Of The Navy

Systems and methods for monitoring of fractional gluconeogenesis and targeting of fractional gluconeogenesis via nutritional support

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“bes”) of a patient, are disclosed. The bes provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient.
Run Them Sweet Llc

Systems and methods for monitoring of fractional gluconeogenesis and targeting of fractional gluconeogenesis via nutritional support

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“bes”) of a patient, are disclosed. The bes provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient.
Run Them Sweet Llc

Btg International Limited

. .

Automatic 3d brain tumor segmentation and classification

A fully automatic brain tumor segmentation and classification method and system improve the healthcare experience with machine intelligence. The automatic brain tumor segmentation and classification method and system utilize whole tumor segmentation and multi-class tumor segmentation to provide accurate analysis..
Sony Corporation

Lens with off-axis curvature center

An off-axis curvature center lens is characterized by an x-y-z coordinate system of the convergence-reducing lens, the off-axis curvature lens comprising a distance-vision region with a non-negative distance-vision optical power, having a front distance-vision surface with a center of front distance-vision curvature, and a rear distance-vision surface with a center of rear distance-vision curvature and a near-vision region with an optical power within 0.5d of the distance-vision optical power, having a front near-vision surface with a center of front near-vision curvature, and a rear near-vision surface with a center of rear near-vision curvature; wherein at least one of an x-coordinate of the center of front near-vision curvature is nasal relative to an x-coordinate of the center of front distance-vision curvature, and an x-coordinate of the center of rear near-vision curvature is temporal relative to an x-coordinate of the center of rear distance-vision curvature.. .
Eyebrain Medical,inc.

Eye-strain reducing lens

An eye-strain reducing lens is characterized by an x-y-z coordinate system, and includes a distance-vision region, having a non-negative distance-vision optical power, configured to refract a light ray, directed by a source at a distance-vision region point at a distance-vision x-distance from a center of the coordinate system, to propagate to an eye-center-representative location; and a near-vision region, having a near-vision optical power that matches the distance-vision optical power within 0.5 d, configured to refract a light ray, directed by the source at a near-vision region point at a near-vision x-distance from the center of the coordinate system, to propagate to the same eye-center representative location, wherein the near-vision x-distance is smaller than the distance-vision x-distance.. .
Eyebrain Medical, Inc.

Low-convergence spectacles

A convergence-reducing lens of a low-convergence spectacle is characterized by a central normal of the convergence-reducing lens that defines a z-axis, and a center of the convergence-reducing lens defines a tangential, centered x-v plane, together defining an x-y-z coordinate system, the convergence-reducing lens comprising a distance-vision region, having a non-negative distance-vision optical pourer, configured to refract a light ray, directed parallel to the z-axis at a distance-vision region point at an x-distance from a y-z plane of the coordinate system, to intersect the y-z-plane at a distance-vision intersection z-distance; and a near-vision region, having a near-vision optical power that matches the distance-vision optical power within 0.5 d, configured to refract a light ray, directed parallel to the z-axis at a near-vision region point at the x-distance of the distance-vision region point, to intersect the y-z-plane at a near-vision intersection z-distance that is greater than the distance-vision intersection z-distance.. .
Eyebrain Medical, Inc.

Novel compounds as rearranged during transfection (ret) inhibitors

This invention relates to novel compounds which are inhibitors of the rearranged during transfection (ret) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to ret dysfunction or where modulation of ret activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (ibs) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, von hippel-lindau syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased ret kinase activity.. .
Glaxosmithkline Intellectual Property Development Limited

Implantable medical device for providing chronic condition therapy and acute condition therapy using vagus nerve stimulation

Disclosed herein are methods, systems, and apparatus for treating a medical condition in a patient using an implantable medical device (imd). The imd is capable of generating a first electrical signal for treating a medical condition, for example epilepsy.
Cyberonics, Inc.

Organic compounds

The present invention relates to novel pyridinoxy phenylpropanamines, their pharmaceutical compositions and methods of use. In addition, the present invention relates to therapeutic methods that penetrate the blood-brain barrier and regulate the norepinephrine and serotonin transporters (“net/sert”)..
Intra-cellular Therapies, Inc.

Therapeutic agents containing cannabis flavonoid derivatives targeting kinases, sirtuins and oncogenic agents for the treatment of cancers

An embodiment of the invention provides a cannabis-based flavonoid pharmaceutical composition including any one or more selected, from among the group of apigenin, cannflavin. A.
Flavocure Biotech Llc

Item of headwear for cooling the head

Headwear for cooling the neurocranium region of a user's head and thereby the user's brain. In particular, the headwear provides selective cooling to specific areas of the parietal region, the frontal region, the temporal region and the occipital region of the cranium associated with the drainage system of the brain following a traumatic injury..

Brain connectivity analysis system and brain connectivity analysis method

Provided is a technique for comprehensively understanding the relationship between brain regions. A brain connectivity analysis system herein includes a memory configured to have stored therein a connectivity analysis program for analyzing the connectivity; and a processor configured to read the connectivity analysis program from the memory and analyze the connectivity.
Hitachi, Ltd.

System and temporal and spatial detection of seizure onset

Many electrodes are positioned inside a skull for obtaining several electric voltage variation wave information. A processing unit computes subtract operation between two neighboring electrical voltage variation wave information respectively and then can obtain electrical voltage difference waves.
Chung Shan Medical University Hospital

Brain-protecting helmet lining apparatus and method

A brain-protecting helmet lining apparatus and method providing pad liners made of a viscoelastic material which deforms in a time-dependent and nonlinear way, and has a capability of storing strain energy when deformed, while dissipating some energy through hysteresis, where, in use, the viscoelastic material will deform, under slight pressure applied consistently, to closely fit the user's head and prevent unwanted movement of the head within the helmet, but upon the application of strain over a short pulse of time from a blow or checked momentum, the viscoelastic material will resist deformation which would loosen the fit to the user's head, and will store and partially dissipate the strain energy, protecting the head and brain of the user.. .

Method and system for automated brain tumor diagnosis using image classification

A method and system for classifying tissue endomicroscopy images are disclosed. Local feature descriptors are extracted from an endomicroscopy image.
Siemens Aktiengesellschaft

Methods of in vitro differentiation of midbrain dopamine (mda) neurons

The presently disclosed subject matter provides for in vitro methods of inducing differentiation of human stem cells into midbrain dopamine neurons, and precursors thereof, and cells generated by such methods. The presently disclosed subject matter also provides for uses of such cells for treating neurodegenerative disorders..
Memorial Sloan-kettering Cancer Center

Progesterone phosphate analogs and uses related thereto

This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation such as those resulting from traumatic brain injury or stroke..
Emory University

Biological co-processor (bcp)

Embodiments may provide a general-purpose, relatively inexpensive, ai-driven implant that is able to adapt to and modulate any given neuron, circuit, or region in the brain, as well as individual cells of any type of tissue. For example, in an embodiment, a method for interacting with living tissue may comprise attaching a device to a body of a person or animal, the device comprising plurality of carbon fibers in contact with the living tissue, receiving by the carbon fibers signals from the living tissue, processing the received signals by the device, and transmitting the processed signals..

Devices, delivering coffee-derived volatiles

Devices, systems and methods are provided for delivering coffee-derived volatiles to a user, particularly for the treatment of addiction. The coffee volatiles are selected and delivered by devices and systems which allow for concentrated delivery to the olfactory system of the user in a controlled manner.

Endoscope handle with a rigid surgical suction for endoscopic micro-neurosurgery of the brain

A handle for endoscope for two handed micro neurosurgery of the brain comprising adjustable rigid surgical suction, channel for endoscope, surgical suction control hole.. .

Novel methods of use of tetrahydroberberine (thb)

Tetrahydroberberine (thb), isolated from the chinese herb “corydalis ambigua”, exhibits a variety of pharmacological effects, although mechanisms of action are unclear or entirely unknown. Described herein are novel methods of using tetrahydroberberine (thb), thb analogs or derivatives, tetrahydroprotoberberines (thpb).
Dignity Health

Unitary multilumen cranial bolt

A unitary multilumen cranial bolt for use in multimodal monitoring of a plurality of physiological parameters in brain tissue incorporates a plurality of lumens, each lumen directing a catheter borne sensor through a bore hole in the cranium and into brain tissue of a patient. The lumens are configured to cause the catheters to splay outward as they enter the cranial cavity and reach their intended depth of penetration.
Thermal Technologies, Inc.

Suggest activities according to the dominant nostril

Brain activity, and in particular which hemisphere is relatively more effective, is correlated with the dominant nostril (i.e., the nostril through which most of the air is exhaled when breathing through the nose). Since each side of the brain plays a different role in different types of activities, it may be better to conduct certain activities when a certain nostril is dominant.
Facense Ltd.

Method for estimating perceptual semantic content by analysis of brain activity

A perceptual semantic content estimation method includes: (a) inputting, to data processing means, brain activity induced in a subject by a training stimulation and detected as an output of a brain activity detection means and an annotation of a perceptual content; (b) associating a sematic space representation of the training stimulation and the output of the brain activity detection means in a stored semantic space and storing the association in a training result information storage means; (c) inputting, to the data processing means, an output when the brain activity detection means detects brain activity induced by a novel stimulation, and obtaining a probability distribution in the semantic space which represents perceptual semantic contents for the output of the novel stimulation-induced brain activity by the brain activity detection means on the basis of the association; and (d) estimating a highly probable perceptual semantic content on the basis of the probability distribution.. .
National Institute Of Information And Communications Technology

Method for determining the perceptiveness of a subject

The perceptive faculties of a subject are determined by way of a brain-computer interface 20. At least two mutually distinguishable types of stimuli sa, sb which are applicable to a subject are prescribed.

Electrical stimulation and bio-potential measurement device

An electrical stimulation and bio-potential measurement device is provided. The electrical stimulation and bio-potential measurement device comprises at least one electrode module which comes into contact with the scalp of a user, a current supply unit, connected to the at least one electrode module, for supplying a current to the at least one electrode module so that the at least one electrode module can apply electrical stimulation to the user, and a signal processing unit, connected to the at least one electrode module, for processing bio-potential signals detected by the at least one electrode module, wherein the current supply unit comprises at least one switch which is arranged between the at least one electrode module and a voltage source for supplying the current..
Y-brain Inc.

Identify the dominant nostril using thermal measurements

Brain activity, and in particular which hemisphere is relatively more effective, is correlated with the dominant nostril (i.e., the nostril through which most of the air is exhaled when breathing through the nose). Thus, identifying which of the nostrils is dominant may have various applications.
Facense Ltd.

Dietary supplement for improving brain health

Compositions that can be used to improve human health, and in particular brain health are provided. In some embodiments the composition comprises inositol, n-acetyl l-tyrosine, pyrroloquinoline quinone (pqq), choline bitartrate, l-theanine and acetyl-l-carnitine.
Ovata B.v.

Brain and neural treatments comprising peptides and other compositions

The present invention generally relates to compositions and methods for treatment of subjects in need of muscle growth, muscle repair, improved muscular and neuromuscular control, and treatments for neuromuscular and neurological disorders, including brain disorders. In some cases, the composition may include nitric oxide and/or peptides such as thyrotropin-releasing hormone (trh) and/or gnrh (gonadotropin-releasing hormone).
Ovata B.v.

Image classification by brain computer interface

A method of classifying an image is disclosed. The method comprises: applying a computer vision procedure to the image to detect therein candidate image regions suspected as being occupied by a target; presenting to an observer each candidate image region as a visual stimulus, while collecting neurophysiological signals from a brain of the observer; processing the neurophysiological signals to identify a neurophysiological event indicative of a detection of the target by the observer; and determining an existence of the target in the image is based, at least in part, on the identification of the neurophysiological event..
Innereye Ltd.

Methods for inducing neurogenesis

A method for inducing neurogenesis in the brain of a mammal includes administering a light treatment from an led light source.. .
The Litebook Company Ltd.

Brain stimulation programming

A programming system allows a user to program therapy parameter values for therapy delivered by a medical device by specifying a desired therapeutic outcome. In an example, the programming system presents a model of a brain network associated with a patient condition to the user.
Medtronic, Inc.

Adaptive deep brain stimulation using frequency sub-bands

Techniques are disclosed for delivering electrical stimulation therapy to a patient. In one example, a medical system delivers electrical stimulation therapy to a tissue of the patient via electrodes.
Medtronic, Inc.

Adaptive deep brain stimulation using movement desynchronization

Techniques are disclosed for delivering electrical stimulation therapy to a patient. In one example, a medical system delivers electrical stimulation therapy to a tissue of the patient via electrodes.
Medtronic, Inc.

Skull implanted electrode assembly for brain stimulation

A skull-implantable electrode assembly for delivering pulses of electric current to a patient's brain, comprising an electrode housed in an insulated conduit and threaded through an electrically-conductive cannulated skull screw. Details of the exterior construction are discussed, as well as electrode arrangements and methods of treating a medical ailment of a patient..
King Abdullah International Medical Research Center

Adaptive deep brain stimulation using homeostatic window

Techniques are disclosed for defining a homeostatic window for controlling delivery of electrical stimulation therapy to a patient. In one example, a method includes generating and delivering electrical stimulation therapy to tissue of a patient via electrodes.
Medtronic, Inc.

Compositions for mitigating head trauma

Compositions and methods and provided for preventing or mitigating the effects of traumatic brain injuries, such as concussions. The compositions comprises between 100-11500 mg docosahexaenoic acid (dha), 100-3000 mg curcumin, and 100-3000 mg of resveratrol.

Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity

Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.. .
Auspex Pharmaceuticals, Inc.

Access sheath for brain surgery

A surgical sheath system for performing surgery of the head includes a flexible tubular braided sheath which is radially expandable. An expansion tube is insertable into the sheath to radially expand the sheath.
Spiway Llc

Robotic guide for brain biopsy

Various robotic guides for a biopsy surgical tool are disclosed, of which one includes a main shaft, an end-effector mounted on a distal end of the main shaft, a roll/yaw actuating mechanism, a translational actuating mechanism, and a pitch actuating mechanism. Optionally, the roll/yaw actuating mechanism includes a first actuating mechanism and a second actuating mechanism.
Parseh Intelligent Surgical System

Automated detection of spreading depolarizations

Computer-implemented methods and automated systems for real-time detection of spreading depolarizations in a brain injured patient, based an algorithm of (a) providing a reference data base of spreading depolarization waveform templates generated from eeg recordings of confirmed spreading depolarizations (sd) in a reference brain-injured patient cohort; (b) recording an eeg of the brain injured patient to generate recorded eeg waveforms; (c) detecting a slow potential change present in a recorded eeg waveform by applying a power spectral density estimate to the recorded waveform; (d) comparing a detected spc to a reference database of sd waveform template to identify a candidate sd; and (e) rejecting a candidate sd as a false positive based on overall signal power and amplitude analysis and identifying a non-rejected candidate sd as a detected sd.. .
University Of Cincinnati

System and automatic prediction and prevention of migraine and/or epilepsy

The present invention relates to the field of detecting/preventing migraine attacks. In particular, a system and method for detecting and preventing a migraine episode in a user are provided.
Koninklijke Philips N.v.

Takeda Pharmaceutical Company Limited

. .

Method and information retrieval

This disclosure relates to methods and apparatus for generating criteria for information retrieval tasks. A quantifying unit is trained through machine learning to assign relevance values to functional brain imaging potentials measured from a person.
Helsingin Yliopisto

Preventing split-brain scenario in a high-availability cluster

As disclosed herein is a tool for preventing split-brain scenario, including determining, by a processor, that a first node of a ha cluster is unable to communicate with a second node of the ha cluster, and initiating, by a processor, by the first node, a handshake operation with a connected client, wherein the handshake operation comprises requesting that the client determine a status of the second node and receiving, from the client, a response indicating the status of the second node. Further, accepting, by a processor, new requests in response to determining that the second node is unavailable, and requesting, by a processor, restoration of communications between the first node and the second node in response to determining that the second node is available..
International Business Machines Corporation

Preventing split-brain scenario in a high-availability cluster

As disclosed herein is a tool for preventing split-brain scenario, including determining, by a processor, that a first node of a ha cluster is unable to communicate with a second node of the ha cluster, and initiating, by a processor, by the first node, a handshake operation with a connected client, wherein the handshake operation comprises requesting that the client determine a status of the second node and receiving, from the client, a response indicating the status of the second node. Further, accepting, by a processor, new requests in response to determining that the second node is unavailable, and requesting, by a processor, restoration of communications between the first node and the second node in response to determining that the second node is available..
International Business Machines Corporation

Wearable electronic, multi-sensory, human/machine, human/human interfaces

A wearable haptic humaxi/machine interface (hhmi) receives electrical activity from muscles and nerves of a user. An electrical signal is determined having characteristics based on the received electrical activity.

Hybrid computer interface system

A hybrid system is used to perform screen object manipulation and or external device control. In a first portion of the hybrid system a single camera is used to provide the tracking of a user's pupil.

Regulatory brain specific ctyoplasmic rnas (bc rnas) and methods of use thereof in diagnosis and treatment of neuropsychiatric lupus

Compositions and methods for diagnosing an increased risk of npsle are provided.. .
The Research Foundation For State University Of New York

Time-varying magnetic field therapy using multistable latching mechanisms

The invention provides wearable devices for effecting transcranial magnetic stimulation to be used by patients who have suffered brain injuries. Permanent magnets are shifted or rotated to deliver a time-varying magnetic field, preferably about the locus of the injury.
Rhode Island Board Of Education, State Of Rhode Island And Providence Plantations

System and neurostimulation

A brain stimulation method and system are provided, wherein neuronal signals of a patient are continuously sensed by at least one sensor device and based on the sensed signals, stimulation signals are applied to the patient by at least one stimulation device, wherein the sensed signals are transmitted to a body-external, portable processing device wherein the sensed signals are evaluated, and based on the evaluated signals stimulation control signals are generated and transmitted to the stimulation device where based on the stimulation control signals the stimulation signals are generated.. .
C/o Cortec Gmbh

Visual prosthesis employing virtual neural electrode arrays

The present disclosure relates to a method of generating visual percepts using conformal electrode arrays. The electrode arrays can be placed into the ventricular system or cerebral venous sinuses, which function as minimally invasive techniques for precise spatial and temporal localization of electrical activity within the brain, and precise electrical stimulation of brain tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain.
Precision Neuro Technologies Llc

Providing sensory stimulation based on slow wave periodicity

The present disclosure pertains to a system configured to provide sensory stimulation to a subject (12) during a sleep session. The system includes one or more sensory stimulators (16) configured to provide sensory stimulation to the subject; one or more sensors (18) configured to generate output signals conveying information related to brain activity of the subject; and one or more processors (20) configured to detect individual slow waves in the subject; control the one or more sensory stimulators to provide sensory stimulation to the subject based on the detected individual slow waves; predict a timing for occurrence of a predicted slow wave based on the previously detected individual slow waves; and responsive to not detecting the predicted slow wave at the predicted timing control the one or more sensory stimulators to provide sensory stimulation at the predicted timing for occurrence of the predicted slow wave..
Koninklijke Philips N.v.

Method for lowering thyrotropin levels in adults

The inventor has discovered that a particular dosage of alpha glycerylphosphoryl choline administered to adult males results in a reduction of thyrotropin serum. Thytotropin levels are depressed with increased dopamine levels in the brain, and cdp-choline has been shown to increase dopamine and dopamine receptor density in the cns.
University Of Louisiana At Lafayette

Medicinal agent and beverage/food for preventing cerebral dysfunction and improvidng same

Provided is method for improving depression of a patient by administering to a patient suffering from depression an effective dose of sepiapterin or a pharmaceutically acceptable salt of sepiapterin in an amount from 0.1 to 100 mg/kg of body weight per day. The sepiapterin or salt of sepiapterin entering the patient's bloodstream and passing the patient's blood-brain barrier to enter a neuron, and the sepiapterin or salt of sepiapterin converting to tetrahydrobiopterin in a neuron of the brain and the tetrahydrobiopterin facilitating biosynthesis of an aromatic monoamine in the patient's brain to provide an elevated level of an aromatic monoamine in the patient's brain to improve depression of the patient.

Calculation of perfusion parameters in medical imaging

A method of determining a residue function in brain tissue, from medical images acquired after introducing contrast agent into the blood, correcting for contrast agent leakage into the tissue, comprising: a) providing time signals indicating contrast agent concentration for leaking voxels, a time signal indicating average contrast agent concentration for non-leaking voxels, and an artery input function, all derived from the images; b) fitting the leaking voxel signals to a model time signal with a free parameter for leakage rate, the model assuming that the concentration of contrast agent perfusing through a leaking voxel has a same shape as a function of time as the average contrast agent concentration for non-leaking voxels; c) using the best fit leakage rate parameter to make a correction for leakage to the leaking voxel signals; and d) deconvolving the corrected signals from the artery input function, to find the residue function.. .
Algotec Systems Ltd.

Wearable brain sensors

A wearable apparatus for wearing on a head of a user, the apparatus has a band assembly comprising an outer band member comprising outer band ends joined by a curved outer band portion of a curve generally shaped to correspond to the users forehead; a flexible inner band member comprising inner band ends joined by a curved inner band portion of a curve generally shaped to correspond to the user's forehead, the inner band member is attached to the outer band member at least by each inner band end respectively attached to a respective one of the outer band ends; at least one brainwave sensor disposed inwardly along the curved inner band portion to provide a flexible conductive surface; and a deformable attachment that connects the flexible inner band member to the outer band, the deformable attachment allowing the inner band to conform to the user's forehead shape, the deformable attachment having a biasing component to urge the at the at least one brainwave sensor towards the user's forehead when worn by the user.. .
Interaxon Inc.

Stress detection method and apparatus

Embodiments of the present disclosure provide techniques and configurations for an apparatus for stress event detection. In some embodiments, the apparatus may be a wearable device and may include at least one first sensor disposed on the wearable apparatus to generate a first sensor signal indicative of a brain activity of a user, at least one second sensor disposed on the wearable apparatus to generate a second sensor signal indicative of a heart rate of the user, and at least one third sensor disposed on the wearable apparatus to generate a third sensor signal indicative of a respiration rate of the user.
Intel Corporation

Method and monitoring an organ of a patient

An apparatus for determining tissue versus fluid components of an organ include a detector that generates a detector signal based on electrical signals derived from tissue and fluid. The apparatus includes a signal processor in communication with the detector which subtracts in real time a tissue component from the detector signal and produces a fluid volume signal.
Board Of Regents, The University Of Texas System

Head-mounted electrode array

A headset for defecting brain electrical activity may include a flexible substrate having first and second ends each configured to engage an ear of a subject and dimensioned to fit across the forehead of a subject. The headset may also include a plurality of electrodes disposed on the substrate and configured to contact the subject when the headset is positioned on the subject.
Brainscope Company, Inc

Brain activity detection system, devices and methods utilizing the same

Brain activity detection technologies are disclosed. In some embodiments the technologies include a brain activity detection system that includes a sensor block including that includes at least one reference electrode and at least one sense electrode.
Intel Corporation

Label-free single and multi-photon fluorescence spectroscopy to detect brain disorders and disease: alzheimer, parkinson and autism from brain tissue, cells, spinal fluid and body fluids

A label free single or multi-photon optical spectroscopy for measuring the differences between the levels of fluorophores from tryptophan, collagen, reduced nicotinamide adenine dinucleotide (nadh), and flavins exist in brain samples from a of alzheimer's disease (ad) and in normal (n) brain samples with label-free fluorescence spectroscopy. Relative quantities of these molecules are shown by the spectral profiles of the ad and n brain samples at excitation wavelengths 266 nm, 300 nm, and 400 nm.

Inducing neurogenesis within a human brain

Methods and apparatus for inducing neurogenesis within a human. The invention utilizes an implantable signal generator to deliver high frequency stimulation to deep brain tissue elements.
Eternal Plant Boijl B.v.

Systems, methods, and devices having stretchable integrated circuitry for sensing and delivering therapy

System, devices and methods are presented that integrate stretchable or flexible circuitry, including arrays of active devices for enhanced sensing, diagnostic, and therapeutic capabilities. The invention enables conformal sensing contact with tissues of interest, such as the inner wall of a lumen, a the brain, or the surface of the heart.
Mc10, Inc.

3d imaging

A three-dimensional (3d) imaging method and device, generating a 3d image by only one imaging apparatus. The imaging apparatus is configured to perform the following three functions: converting source light to linear polarized light (s11), transforming, by faraday effect, the linear polarized light into mixed polarized light comprising two polarized lights having different polarization directions (s12), and displaying, according to the mixed polarized light, an image (s13).
Guangzhou Uc Network Technology Co., Ltd.

Metabolomics profiling of central nervous system injury

A method of diagnosing central nervous system injuries such as acquired brain injury (abi) and/or acquired spinal cord injury (asi), including mild tbi (concussion or blast wave), mild asi (contusion, stretch or partial cord transection), non-tbi brain injury and/or non-tsi spinal cord injury in a subject (animal or human). The method includes (a) obtaining a biological test sample from the subject, identifying metabolites in the subject's sample using metabolomics thereby obtaining a subject's metabolite matrix and generating a subject's profile using the patient's metabolite matrix; and (b) using multivariate statistical analysis and machine learning to compare the subject's profile with predetermined set of profiles of cns injuries and a predetermined set of profiles of controls to determine if the subject has a cns injury..
London Health Sciences Centre Research Inc.

Recombinant protein-based the delivery of silencer rna to target the brain

The present invention relates to the design and development of recombinant protein for the delivery of silencer rna complex to mediate rna interference since it represents a novel therapeutic approach to modulate several neurodegenerative disease-related genes across the blood-brain barrier (bbb). To overcome challenges due to this barrier for biologics and other biological complex, the present invention describes a method wherein peptide having sequence gggghlnilstlwkyrc represented by seq id no.
Council Of Scientific & Industrial Research

System and operating remote controlled toys using brainwaves

A system and method for controlling a remote control assembly with precision using signals detected by low-cost brainwave sensors. A brainwave detection unit senses brainwaves and produces corresponding data signals.

Coil use in transcranial magnetic stimulation increasing current generated by induced electric field

A coil apparatus for use in a transcranial magnetic stimulation apparatus is provided in which the coil apparatus includes a coil arranged to oppose a surface of a head of a human to generate a current by an induced electric field in a magnetic stimulation-target region in a brain by electromagnetic induction, and to stimulate neurons. The coil apparatus includes the coil configured by winding a conductive wire along a predetermined reference surface; and a magnetic body arranged between the head and the coil to oppose the coil, and arranged at a position at an opposite side of the head.
Osaka University

Magnetic stimulation coils and ferromagnetic components for reduced surface stimulation and improved treatment depth

A tms device may include treatment coils and ferromagnetic components that are configured to be disposed proximate to corresponding ones of the treatment coils. The treatment coils and ferromagnetic components of the tms device may cooperatively generate a magnetic field that exhibits one or more characteristics that differ from those of a magnetic field that is generated by the treatment coils alone.
Neuronetics, Inc.

Wireless midfield systems and methods

Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters.
The Board Of Trustees Of The Leland Stanford Junior University

Identification of compromised components in a medical system

In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity..
Medtronic, Inc.

Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrilary tangles

Or their pharmaceutically acceptable salts, which may be suitable for imaging tau aggregates, b-sheet aggregates, beta-amyloid aggregates or alpha-synuclein aggregates, and hence are useful in binding and imaging tau aggregates in alzheimer's patients. More specifically, this invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (pet) imaging to study tau deposits in brain in vivo to allow diagnosis of alzheimer's disease and other neurodegenerative diseases characterized by tau pathology.

Intranasal administration of guanidinylated aminoglycosides

This disclosure relates to intranasal administration of conjugates comprising guanidinylated aminoglycosides (“guanidinoglycosides”) and a polypeptide (e.g., an enzyme, antibody, or polypeptide growth factor). For example, such administration methods are useful for delivering a polypeptide to the brain and/or cerebrospinal fluid.
The Regents Of The University Of California

Methods of treating cognitive impairments or dysfunction

The present disclosure provides methods for treating one or more of cognitive deficits or cognitive impairments associated with or caused by mild brain injuries, chemotherapy treatment, chemotherapy medication, post-chemotherapy cognitive impairment (pcci), chemo brain, and other disorders arising from cognitive dysfunction in a subject by administering to the subject an effective amount of a composition comprising ghrelin or a ghrelin variant.. .
Oxeia Biopharmaceuticals, Inc.

Brain, spinal, and nerve injury treatment

A treatment for brain, spinal and nerve injury comprising use of a substance p receptor antagonist optionally in combination with a magnesium compound. There is also provided a formulation for use in this treatment comprising a substance p receptor antagonist and a magnesium compound..
Eustralis Pharmaceuticals Limited

Compositions and methods for treating microbiota-related psychotropic conditions and diseases

In alternative embodiments, the invention provides compositions and methods for treating, ameliorating and preventing various disorders and conditions in manunals, including genetically-predisposed and chronic disorders, where the microbial or bacterial flora of the bowel is at least one causative or symptom-producing factor, for example, where the microbial or bacterial flora of the bowel manufactures neurotoxins or neurotoxic agents that enter the body through the gastrointestinal (01) tract, e.g. The colon, and reach the systemic space, e.g., by neural streaming or via the circulation, to reach the central nervous system (cns), including the brain, the peripheral nervous system (pns), and other nervous systems.

Catheter with jet impingement cooled thermoelectric module

Cryocatheter including an elongated flexible catheter member having a short rigid catheter tip for introduction into a therapy site and a heat exchange arrangement for freezing the catheter tip to a cryo-temperature from between about −15° c. To about −30° c.
Berger Thermal Research Ltd.

Helmet omnidirectional energy management systems

An embodiment of a safety helmet for protecting the human head against repetitive impacts, moderate impacts and severe impacts so as to significantly reduce the likelihood of both translational and rotational brain injury and concussions includes an outer shell, an outer liner disposed within and coupled to the outer shell, and an inner liner disposed within and coupled in spaced opposition to the outer liner by a plurality of isolation dampers for omnidirectional movement of the inner liner relative to the outer liner and the outer shell.. .
6d Helmets, Llc

Diagnostic method

A method of detecting the presence, or monitoring the severity of a condition characterised by the presence of fragments of a marker protein in the brain of a patient. The method comprises: (i) providing a sample comprising macrophages obtained from the patient; and (ii) detecting the presence of the marker protein or fragments thereof in the macrophages.
Suntory Flowers Limited

Blood brain barrier models and methods to generate and use the same

The present disclosure generally relates to a process to prepare a cell culture system that mimics the structure of blood brain barrier (bbb) and are useful to study the functions thereof. In particular, the present invention relates to a direct-contact coculture and triculture systems prepared by plating bmecs on a pre-formed lawn of coculture of astrocytes and pericytes on the apical surface of a culture-chamber to achieve a truly direct contact triculture model for bbb.
Purdue Research Foundation

Dna-methylation based classifying tumor species

The present invention pertains to methods for classifying tumorous diseases based on their specific genomic dna methylation profile. The invention provides a method that allows for a classification of a tumor sample obtained from a patient by analysing a multitude, preferably genome wide, collection of cpg positions by comparison to a classification rule derived from a set of methylation data acquired from pre-classified tumor species.
Ruprecht-karls-universität Heidelberg

Widespread gene delivery to motor neurons using peripheral injection of aav vectors

The present invention relates to compositions and methods, in particular to methods based on systemic injection of raav, for delivering genes to cells of the central nervous system in mammals, such as brain neurons or glial cells, and in particular to motor neurons or glial cells of the spinal cord the invention also relates to methods of treating motor neuron disorders in mammals by expression of therapeutic genes. The invention stems from the unexpected discovery that peripheral injection of aav vectors leads to a bypass of the blood brain barrier and a massive infection of motor neurons.
Centre National De La Recherche Scientifique

1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2-yl carbamate derivatives as magl inhibitors

And pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating magl-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, traumatic brain injury, depression, anxiety, alzheimer's disease, a metabolic disorder, stroke, or cancer.. .

Ultrasonic stimulation device using guide framework

A guide framework for positioning an ultrasonic transducer which emits a focused ultrasound to a target point in carrying out surgery to apply ultrasonic stimulation to a subject's brain, includes a body in a shape of a mask that is laid on the subject's face, and a positioning hole formed through an inner surface and an outer surface of the mask body, the positioning hole into which the ultrasonic transducer is inserted, wherein the inner surface of the mask body is formed to conform a facial contour of the subject, and when the guide framework is laid on the subject's face and the ultrasonic transducer is disposed at the positioning hole, the position of the target point is naturally disposed at a preset stimulation site of the brain. An ultrasonic stimulation device includes an ultrasonic transducer and the guide framework for positioning the ultrasonic transducer..
Korea Institute Of Science And Technology

Central base coils for deep transcranial magnetic stimulation

A transcranial magnetic stimulation coil which is location-specific for medial brain regions or lateral brain regions is designed with multiple spaced apart stimulating elements having current flow in a first direction, and multiple return elements having current flow in a second direction which is opposite the first direction. The multiple stimulating elements are distributed around a central axis of the coil..
Brainsway Ltd.

Method of correlating brain activity

The present invention includes systems and methods of using real-time neurofeedback to improve the correspondence between first-person experience and specific brain activation patterns in a manner that minimally affects the experience itself. The present invention provides meditators the ability to enhance their control over their own brain activity, such as posterior cingulate cortex (pcc) activation.
Yale University

Compositions of medicinal plants for reducing the effects of aging, prevention and treatment of age-related neurodegenerative diseases, and treatment of anxiety and sleep disorders

Compositions comprising extracts prepared from mixtures of the herbal plants radix bupleurum chinense dc (“b”), rhizoma corydalis yanhusuo wt wang (“y”), caulis polygonum multiflorum thunb (“p”) and flos albizia julibrissin durazz (“a”) are provided. The byp, bya, bpa, by, bp, yp and bypa extracts significantly decreased one or more of the effects of accelerated aging in mice exposed to d-galactose, including spatial memory deficit, and elevated oxidative stress marker malondialdehyde and pro-inflammatory cytokines tnf-alpha and il-6 in the brain, indicating efficacy in reducing the damage of aging, and preventing and treating alzheimer's disease and/or parkinson's disease.
Pharmacogenetics Limited

Nutritional composition with human milk oligosaccharides and uses thereof

The present disclosure generally relates to pediatric nutritional compositions including a human milk oligosaccharide or a precursor thereof. Further, the nutritional compositions may include a prebiotic mixture of galacto-oligosaccharide and/or polydextrose, a probiotic, such as lactobacillus rhamnosus gg, and human milk oligosaccharides.
Mead Johnson Nutrition Company

Small molecule therapeutic compounds that reduce the incidence of intracerebral hemorrhage and brain microhemorrhages

The described invention relates to small molecule therapeutic compounds capable of reducing the incidence of intracerebral hemorrhage and brain microhemorrhages identified using zebrafish and mouse models of intracerebral hemorrhage and brain microhemorrhages.. .
St. Michaels Hospital

Modeling blood-brain barrier in vitro

Synthetic human blood vessels can be constructed using human brain derived endothelial cells and incorporated into a tissue model that contains astrocytes and other neurons and microglia. Multi-cell type microvessels incorporate cell types such as astrocytes and pericytes in order to construct a highly representative blood-brain barrier in vitro model with a functional lumen containing brain-derived microvascular endothelial cells and a polymer wall containing human astrocytes and/or pericytes..
The Government Of The United States Of America, As Represented By The Secretary Of The Navy

Methods of protecting against brain injury

The present disclosure provides methods of maintaining brain function, memory function and reducing the prevalence of mild traumatic brain injury in an individual at risk of experiencing a mild traumatic brain injury. The present disclosure also provides methods for administering various human dietary supplements to individuals at risk of experiencing a mild traumatic brain injury..
Natural Alternatives International, Inc.

Composition comprising siallyllactose for use in enhancing learning skills and memory function

This invention relates to the use of a nutritional composition comprising sialylated oligosaccharides for enhancing cognitive development and learning skills in mammals. The nutritional composition comprises 3′-siallylactose (3′-sl) and 6′-siallylactose (6′-sl) in a weight ratio between 10:1 and 1:10 and is specifically for use in enhancing learning skills and/or enhancing memory function in an individual by increasing the sialic acid (neu5ac) concentration in the brain of said individual..
Nestec S.a.

Raumedic Ag

. .

. .

Development of spinal cord on a microfluidic chip

The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems..
Cedars-sinai Medical Center

Blood brain barrier transport molecules and uses thereof

The disclosure provides transporter molecules capable of carrying agents of interest across the blood brain barrier. Also provided are polynucleotides encoding transporter molecules, methods making transporter molecules, and methods of using transporter molecules, e.g., for the diagnosis, prevention, or treatment of central nervous system diseases, disorders, or injuries..
Medimmune Limited

Dicam-specific antibodies and uses thereof

Novel antibodies directed against dual ig domain containing cell adhesion molecule (dicam) are described. These anti-dicam antibodies are capable of detecting dicam by western blot and/or flow cytometry, blocking the interaction between dicam and its ligand αvβ3 integrin, and/or blocking the migration of inflammatory cytokine-secreting th17 lymphocytes across the blood brain barrier.
Centre Hospitalier De L'université De Montréal

Ang (1-7) derivative oligopeptides and methods for using and producing the same

The present invention provides oligopeptides, in particular, ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment..
Arizona Board Of Regents On Behalf Of The University Of Arizona

Inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease

Disclosed herein are compounds which inhibit the kinase activity of dual leucine zipper (dlk) kinase (map3k12), pharmaceutical compositions, and methods of treatment of dlk-mediated diseases, such as neurological diseases that result from traumatic injury to central nervous system and peripheral nervous system neurons (e.g. Stroke, traumatic brain injury, spinal cord injury), or that result from a chronic neurodegenerative condition (e.g.
Board Of Regents, The University Of Texas System

Skull implanted magnet assembly for brain stimulation

A skull-implantable magnet assembly for delivering a static magnetic field to a patient's brain, comprising a rod-shaped magnet housed within a skull screw, removably attached to a casing housing at least one flat magnet, is described. Details of the exterior construction are discussed, as well as magnet arrangements and methods of treating a brain tumor or neurological ailment of a patient..
King Abdullah International Medical Research Center

Therapy device with current titration

An ect system capable of focusing the electrical signals on a specific portion of the patient's brain is provided. The ect system includes a means of applying unidirectional electrical signals and asymmetric electrodes for focusing the signals on the patient.
Mecta Corporation

Neuronal specific targeting of caveolin expression to restore synaptic signaling and improve cognitive function in the neurodegenerative brain and motor function in spinal cord

The invention provides an expression system for producing caveolin-1 in neuronal cells or neural stem cells comprising a neuron-specific regulatory element and a nucleic acid sequence encoding caveolin-1.. .
The Regents Of The University Of California

Regulation of brain biogenic amines associated with depression by a formulation from botanical source

Provided herein are anti depressant and anxiolytic herbal formulations including: 225-450 mg of nyctanthes arbortristis, 250-550 mg ocimum tenuiflorum, 200-450 mg hippophae salcifolia, and optionally additives selected from minerals, vitamins, salt, filler and binder. Also provided are methods of making such formulations and methods of using such formulations for treating or improving brain function..

Treatment for ischemic stroke

Granulocyte colony-stimulating factor (g-csf; a stem cell enhancer and facilitator), detc-meso (a glutamate receptor partial antagonist and anti-excitotoxicity agent), and sulindac (a potent anti-oxidant and anti-inflammatory agent) each can protect brain tissue exposed to a cerebral ischemia/reperfusion injury, and minimize the size of infarcts that develop as a result of the injury. When administered in combination, these agents are effective at protecting brain tissue and minimizing the size of an infarct resulting from the injury at much lower concentrations compared to using a single agent..
Chs Pharma, Inc.

System and assessing electrical activity using an iterative sparse technique

Three-dimensional electrical source imaging of electrical activity in a biological system (e.g., brain or heart) may involve sensor array recording, at multiple locations, of signals (e.g. Electrical or magnetic signals) of electrical activity.
Regents Of The University Of Minnesota

Transmission transmitting brain parameter sensor data

The result is a transmission apparatus which is designed for use in a domestic patient environment.. .

Method for training and development of craft skills

A method of learning is provided that is dedicated to advancing the expertise of participants in a workforce by utilizing advanced cognitive processes that deepen mastery of complex subject matter. The method is designed to deliver brain-based, customized learning activities that utilize multiple senses and educational touch points.
Society Of Cable Telecommunications Engineers, Inc.

Volition and visual enhancing processes embedded in wearable device

The interaction of human functions and internet data assisted by a wearable computational device that allows direct volition manifestation over internet links on offer employing eye tracking web navigation technology is a brain empowering revolution. A wearable computational device that incorporates a video camera that feeds life video of our surroundings back to the user of this device has resolved the natural human limitation to multitask while on the move.

Apparatus and detecting brain fingerprint using causal connectivity of brainwave

When a brain fingerprint is detected, a predetermined visual stimuli is output on a screen of a display, causal connectivity formed by unique eeg signals of a subject between two or more brain regions from among a predetermined plurality of brain regions is detected on the basis of the eeg signals of the subject who selectively attends to a part corresponding to a letter or symbol conceived by the subject from among the visual stimuli output on the screen of the display, an activation pattern of causal connectivity between brain regions is recognized on the basis of the detected causal connectivity, and the subject is identified by using the recognized unique activation pattern of causal connectivity between brain regions as a brain fingerprint.. .
Korea University Research And Business Foundation

Systems and methods for monitoring of blood lactate and targeting of blood lactate via nutritional support

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“bes”) of a patient, are disclosed. The bes provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient.
Run Them Sweet Llc

Methods for differentiating pluripotent cells

Methods are provided, in some aspects, for differentiating pluripotent cells into midbrain dopaminergic (da) neurons using a mono-smad inhibition or inhibition of smad signaling with only one smad inhibitor. In some embodiments, mono-smad inhibition utilizes a single inhibitor of bone morphogenic protein (bmp) for differentiating pluripotent cells into midbrain da neurons..
Cellular Dynamics International, Inc.

19-nor neuroactive steroids and methods of use thereof

Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to formula (1): and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, tinnitus, and status epilepticus..
Sage Therapeutics, Inc.

Composition and treating metabolic disorders

Bromocriptine citrate administered to a vertebrate, animal or human, can be used for any purpose including, e.g., the long-term modification and regulation of metabolic disorders, including prediabetes, obesity, insulin resistance, hyperinsulinemia, hyperglycemia and type 2 diabetes mellitus (t2dm) and/or, e.g., the treatment of other medical disorder(s) including immune or endocrine disorders or diseases. Bromocriptine citrate is administered over a limited or extended period at a time of day dependent on re-establishing the normal circadian rhythm of central dopaminergic activity of healthy members of a similar species and sex.
Veroscience Llc

Immunotherapy compositions and methods for treatment of tauopathy and transgenic mouse

This disclosure describes, in one aspect, immunogens effective for treating and/or diagnosing tauopathy, and immunotherapeutic compositions and methods involving those immunogens. Generally, the immunogen includes an antigen presentation component and a microtubule-associated tau protein (mapt) component linked to at least a portion of the antigen presentation component.
Stc. Unm

Topical regional neuro-affective therapy with caryophyllene

A method of treating a disease state or condition in humans via topical brainstem afferent stimulation therapy via the administration of caryophyllene to the back of the neck of a human patient to provide regional neuro-affective therapy is disclosed. In certain embodiments, the drugs are incorporated into a pharmaceutically acceptable topical carrier, e.g., a cream, gel, lotion or foam..
Afgin Pharma, Llc

System and noninvasive identification of cognitive and behavioral goals

A brain machine interface system for use with an electroencephalogram to identify a behavioral intent of a person is disclosed. The system includes an electroencephalogram configured to sense electromagnetic signals generated by a brain of a person.
Teledyne Scientific & Imaging, Llc

Stroke catheter for use in revascularization procedures and using same

A method of removing vascular blockage includes providing a catheter system, comprising an outer catheter, a bypass catheter, and a guidewire. In the catheter system, the bypass catheter is slidably disposed within the outer catheter.

Sleep tracking systems, methods, and devices

Provided are mechanisms and processes for tracking sleep. Devices may include an accelerometer configured to measure macro and micro sensitivity movement of head, movement of throb of vessels close to the ear, monitor changes in heart rate and pulse rate and blood pressure.

Diagnostic brain injury based on emg frequency power spectra analysis

A method and a device for diagnosing brain injury (e.g. Concussion) based on analysis of electromyogram (emg) signals and presence of neurological modulation impairment of motor activity are described.

Dynamic display customizing a controller in a display system

A method, or corresponding dynamic display system, for customizing a controller of a display system includes presenting a visual stimulus to a subject at at least one known location relative to the subject's eye gaze; measuring brain activity of the subject's left and right brain hemispheres in response to the subject's viewing of the stimulus; processing the measured brain activity to determine a frequency-dependent metric of the measured brain activity; assessing independent cognitive capacities of the subject's left and right brain hemispheres based on the frequency-dependent metric; and adjusting a function of the controller in the display system according to the assessed independent capacities, such as by adjusting the function to change a stimulus load in a visual hemifield according to the brain activity in the contralateral brain hemisphere. Example applications include head-up display (hud), augmented reality (ar) or virtual reality (vr) display systems, and brain injury assessment systems..
Massachusetts Institute Of Technology

Shear-thickening fluid cowl for cervical spine protection

The described invention, shear-thickening fluid cowl for cervical spine protection, is a hollow hood connected to the wearer's helmet and rear body-armor plate. It is composed of baffles and shear-thickening fluid.

Generation of an inducible pericyte-specific cre mouse model

Pericytes are mural cells of brain capillaries that degenerate in multiple neurological disorders. Pericytes regulate neurovascular functions, but their role in the adult brain and disease is still poorly understood because of the lack of adequate pericyte-specific experimental models.
University Of Southern California

Impact-driven traumatic brain injury testing apparatus

The present invention provides an apparatus and methods to quantitatively measure a physical perturbation to a human head model by a mechanical impact of a blunt trauma. The apparatus is configured to obtain a set of non-contact measurement data from the human head model upon the mechanical impact.

Biguanide compound and use thereof

The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis..
Immunomet Therapeutics Inc.

Electrical stimulation device

Provided is an electrical stimulation device. The electrical stimulation device includes a first electrode that contacts a first portion of the head of a user to apply a current to the head of the user, a second electrode that contacts a second portion that is different from the first portion of the head of the user to apply a current to the head of the user, a controller that performs a control such that polarities of the first electrode and the second electrode can be changed based on a reference comprising at least one of a reference time, a reference ph index, and a reference number of uses..
Y-brain Inc

Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors

Systemic administration of intact, bacterially derived minicells results in rapid accumulation of the minicells in the microenvironment of a brain tumor, in therapeutically significant concentrations, without requiring endothelial endocytosis/transcytosis across the blood brain barrier or any other mechanism by which, pursuant to conventional approaches, nanoparticles have entered into that microenvironment. Accordingly, a wide variety of brain tumors, both primary and metastatic, can be treated by administering systemically a therapeutically effective amount of a composition comprised of a plurality of such minicells, each minicell being a vehicle for an active agent against the tumor, such as a radionuclide, a functional nucleic acid or a plasmid encoding one, or a chemotherapeutic agent..
Engeneic Molecular Delivery Pty Ltd

Recombinant glut1 adeno-associated viral vector constructs and related methods for restoring glut1 expression

The present invention relates to recombinant glut1 adeno-associated viral vector (raav) constructs and related methods for restoring glut1 expression in glut1 deficient mammals. In certain embodiments, the raav further comprises a chicken β-actin promoter wherein the raav is capable of crossing the blood-brain barrier (bbb).
University Of Massachusetts

Human cord blood as a source of neural tissue repair of the brain and spinal cord

The present invention relates to the use of umbilical cord blood cells from a donor or patient to provide neural cells which may be used in transplantation. The isolated cells according to the present invention may be used to effect autologous and allogeneic transplantation and repair of neural tissue, in particular, tissue of the brain and spinal cord and to treat neurodegenerative diseases of the brain and spinal cord..
Saneron Ccel Therapeutics, Inc.

Phosphodiesterase inhibitors to repair brain and/or retinal injury in human newborns

The present disclosure concerns the use of a phosphodiesterase inhibitor, such as, for example, sildenafil, to repair a brain and/or a retinal injury in a newborn. The phosphodiesterase inhibitor can be used in a premature or a term baby that has been exposed to hyperoxia or hypoxia which caused a brain and/or a retinal injury..

Method of treating a brain tumor

Disclosed herein are methods of treating a brain tumor by administering plinabulin. Some embodiments relate to treatment of glioblastoma multiforme by administering plinabulin..
Beyondspring Pharmaceuticals, Inc.

System and intraoperative characterization of brain function using input from a touch panel device

Systems and methods are provided for performing an intraoperative assessment of brain function based on input that is obtained using a touch panel device, in response to a task, and in the presence of an intervention that is applied to a selected region of the brain. The intervention may be stimulation of the selected region of the brain, such as direct cortical stimulation.
Providence St Joseph's And St Michael's Healthcare

Wireless wearable brain blood-oxygen monitoring system

The wireless wearable brain blood-oxygen monitoring system provided by the present application comprises a monitoring control device, a detection device, a fixing device and a flexible printed circuit board; said monitoring control device is used for processing a first optical signal to generate a digital signal and sending said digital signal to a portable mobile terminal; said detection device is used for receiving the first optical signal sent by said monitoring control device, and calculating a degree of blood-oxygen saturation in a detected area according to an incident light intensity and an emergent light intensity of the first optical signal; said flexible printed circuit board is used for fixing a photoelectric conversion means in said detection device; said fixing device is used for fitting said monitoring control device and said detection device to the forehead. The present application can make the brain blood-oxygen monitoring system to monitor in real time and can make it portable..
Institute Of Automation Chinese Academy Of Sciences

Intraoperative guidance system for tumor surgery

The current invention pertains to a system and methods of identifying a site in a tissue of a patient as neoplastic or normal. The system comprises a source of electromagnetic signals; an optical probe which delivers the electromagnetic signals to a working end of the probe; a spectrometer which acquires diffuse reflectance electromagnetic signals returned from the site probed by the optical probe.
The Florida International University Board Of Trustees

Geo-poland Sp. Z.o.o.

. .

Method and stimulating stereoscopic depth perception of stereoscopic data inside head mounted displays when viewing panoramic immersive stereoscopic content

Apparatuses and methods are provided that stimulate realistic 3d depth perception from 3d image data. The solution helps the brain perceive a more realistic depth by placing an object, which may or may not be transparent, in virtual 3d space such that the object appears close to the user inside the panoramic viewer in order to give the brain a close point to reference in 3d space where it might normally struggle to perceive depth at the border of two opposing perceptions of 3d depth for the brain..

Apparatus for augmenting human vision

The functional effect of having additional color-sensing cone types in the human eye is implemented by an encoding of some spectral information differently for the left and right eyes. This different encoding for identical features seen by the left and right eyes is interpreted as a perceptively different feature by the human brain, allowing additional spectral information to be conveyed through the limited tristimulus sensitivity of the human eye..
Wisconsin Alumni Research Foundation

Brain actuated control utilizing visually evoked potentials

A brain-to-computer interface providing brain actuated control of hardware or software associated with said computer is effected by releasably attaching a plurality of high-impedance dry ag/ag—cl electrodes to selected locations on a human user's scalp; providing a low-noise, high-gain, instrumentation amplifier electrically associated with said plurality of electrodes; utilizing a high-resolution analog-to-digital (a/d) converter electrically associated with said instrumentation amplifier and said computer to digitize electroencephalographic signals detected by said plurality of electrodes; and, analyzing said digitized electroencephalographic signals utilizing a computer algorithm to detect steady-state evoked potentials in response to visual stimuli for use in providing control inputs to said hardware or software.. .

Diagnostic pediatric acute-onset neuropsychiatric syndrome (pans) and pediatric autoimmune neuropsychiatric disorder associated with streptococci infection (pandas)

The present invention provides a panel of at least five clinical analyses or tests (using serum samples) to determine the risk of pediatric acute-onset neuropsychiatric syndrome (pans) and/or pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (pandas) in an individual. These include enzyme linked immunosorbent assays (elisas) to measure antibody titers against neuronal antigens present in the brain; the neuronal antigens include lysoganglioside, tubulin, dopamine receptor d1, dopamine receptor d2, serotonin receptor 5ht2a, and serotonin receptor 5ht2c.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv

Epcam aptamers and conjugates thereof

The present disclosure relates to an epcam aptamer or an epcam aptamer conjugate having bi-functional activity and to uses thereof. In particular, the present disclosure also relates to an aptamer conjugate which binds to the transferrin receptor (tfr) and epcam which is useful for treatment of brain tumours and/or brain metastasis..
Deakin University

Vaccines for preventing meningococcal infections

The present invention stems from the finding that the interaction between the β2 adrenoceptor (β2ap) and type iv pilus-associated proteins initiates a process leading to the opening of the blood brain barrier. The invention therefore pertains to a vaccine for preventing the spreading of meningococci into the meningeal space, wherein said vaccine allows the production of antibodies inhibiting the interaction between the type iv pilus-associated proteins and the β2ap..
Universite Paris Descartes

Prodrugs riluzole and their use

Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process..
Biohaven Pharmaceutical Holding Company Ltd.

N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and n-(4- hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamides and their therapeutic use

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted n-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as hmc compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, inflammation and/or joint destruction and/or bone loss; disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; inflammatory and autoimmune disorders, for example, rheumatoid arthritis; psoriasis; psoriatic arthritis; chronic obstructive pulmonary disease (copd); asthma; atherosclerosis; inflammatory bowel disease; ankylosing spondylitis; multiple sclerosis; systemic lupus erythematosus; sjogren's syndrome; a disorder associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, or paget's disease; cancer, such as a haematological malignancy, such as multiple myeloma, leukemia, or lymphoma, or a solid tumour cancer, such as bladder cancer, breast cancer (female and/or male), colon cancer, renal cell carcinoma, kidney cancer, lung cancer, pancreatic cancer, gastric cancer, prostate cancer, brain cancer, skin cancer, thyroid cancer, basal cell ameloblastoma, or melanoma; a disorder associated with fibrosis, such as systemic sclerosis or scleroderma; or a rare vasculitide, such as behçet's disease.
Pimco 2664 Limited

Ancillary device for electrical stimulation device and electrical stimulation device

Provided are an ancillary device for an electrical stimulation device and an electrical stimulation device. The ancillary device is usable for an electrical stimulation device including at least one electrode that contacts the head of a user to apply a current to the head of a user, and includes a reverse current supplier that contacts the at least one electrode of the electrical stimulation device, and a controller that controls the reverse current supplier such that a reverse current is supplied to the at least one electrode to neutralize the at least one electrode..
Y-brain Inc

High-resolution brain machine interface with magnetically-responsive array switches coupled to an internal antenna

A neuronal tissue-machine interface apparatus includes an array of magnetically-responsive switches positioned in close proximity or contact to neuronal tissue of a human subject, wherein a magnetic environment of the plurality of magnetically-responsive switches varies along the array, and an antenna that is electrically connected to the array, wherein a subset of the magnetically-responsive switches respond to electromagnetic energy received by the antenna, and wherein the response of the subset of the magnetically-responsive switches includes modulation of an electrical current conducted by the subset of the magnetically-responsive switches.. .
Weinberg Medical Physics, Inc.

Electrical stimulation device

Disclosed is an electrical stimulation device. The electrical stimulation device includes at least one electrode unit that contacts the head of a user to apply a current to the head of the user, and a current providing module that provides a current to the at least one electrode unit, wherein the current providing module includes a plurality of pads disposed on a path for providing the current to the at least one electrode unit to be spaced apart from each other, and wherein the current providing module provides the current to the at least one electrode unit if the plurality of pads are connected to each other by a conductive material..
Y-brain Inc.

Delivery of polynucleotides using recombinant aav9

The present invention relates to adeno-associated virus 9 methods and materials useful for systemically delivering polynucleotides across the blood brain barrier. Accordingly, the present invention also relates to methods and materials useful for systemically delivering polynucleotides to the central and peripheral nervous systems.
Nationwide Children's Hospital

Methods for enhancing the delivery of molecules across the blood brain barrier

The present invention relates to methods and compositions for enhancing the delivery of an agent across the blood brain barrier utilizing a composition comprising an inhibitor of pikfyve.. .
Lam Therapeutics, Inc.

Composition for preventing, ameliorating, or treating neurological disease containing osmotin peptide as active ingredient

A method of preventing or treating neurological disease includes administering to a subject in need thereof, a composition comprising an osmotin peptide selected from the group consisting of (a) an osmotin peptide having the amino acid sequence of seq id no: 1, and (b) an osmotin peptide having at least one amino acid residue substitution, deletion or insertion in the amino acid sequence of seq id no: 1. When a subject is treated with the osmotin peptide, nerve cells show no increase in growth rate, have little cytotoxicity, and suppress cell death, and when the osmotin peptide is administered to an animal model, the osmotin peptide infiltrated into the hippocampus of the brain and the hypothalamus of the brain, which is the deep part of the brain.
Industry-academic Cooperation Foundation Gyeongsang National University

Riluzole prodrugs and their use

Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process..
Biohaven Pharmaceutical Holding Company Ltd.

A protecting against carbonyl stress induced ischemia-reperfusion injury in the diabetic brain via administration of n-acetylcysteine

A method for one of preventing and minimizing diabetes pathology in a mammal, comprising administering to the mammal an effective amount of n-acetylcysteine (nac).. .
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College

Systems and methods for in vivo detection of electrophysiological and electrochemical signals

Systems and methods for measuring electrophysiological and electrochemical signals in a portion of a body of a subject are provided. The structure includes an array of electrochemical sensors made of miniaturized multi-layer graphene, an array of electrophysiological electrodes, an integrated front-end readout circuit, and narrow silicon shafts with metal spines.
New York University

Ang-(1-7) derivative oligopeptides for the treatment of pain and other indications

The present invention provides oligopeptides, in particular, ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/or impairment, pain, and traumatic brain injury..
Hogenboom Phloxen

Physiological phantoms incorporating feedback sensors and sensing materials

Disclosed herein are physiological phantoms incorporating sensors and sensor materials integrated with a tissue phantom of an anatomical part. The sensors and sensor materials include small diameter optical fibers containing bragg gratings, thermochromic materials, electrical strain gauges, flexible strain gauges, shape sensing cables, electrochromic materials and etc.

A novel nervous system-specific transmembrane proteasome complex that modulates neuronal signaling through extracellular signaling via brain activity peptides

The inventors surprisingly found that neural stimulation caused the synthesis and degradation of proteins into peptides which were then secreted into the cell media within minutes of stimulation by a novel neural-specific and membrane bound proteasome (neuronal membrane proteasome or nmp) that is transmembrane in nature. These secreted, activity-induced, proteasomal peptides (snapps) range in size from about 500 daltons to about 3000 daltons.
The Johns Hopkins University

Detecting dementia and alzheimer's disease associated biomarkers stabilized on solid support materials

Embodiments of the invention provides a method for detecting one or more biomarkers derived from a body fluid, comprising performing one or more assays for the biomarkers from a sample of the body fluid, whereby the sample is previously preserved on a solid support; wherein a change in the biomarkers provides an indication of a biological event in the brain. The invention also provides related methods for identifying a person as being at risk of dementia or alzheimer's disease, monitoring a person for the onset or progression of dementia or alzheimer's disease, evaluating the effectiveness of a potential pharmaceutical agent..
Ge Healthcare Uk Limited

Identification of a 5-gene expression signature predicting clinical outcome of patients with brain tumors

High-grade gliomas are the most common brain tumors in humans and are essentially incurable. The defining hallmark of these high-grade gliomas is the presence within the tumor mass of highly tumorigenic cellular subpopulations that fuel tumor aggressiveness.
The Trustees Of Columbia University In The City Of New York

Method for improving learning

The invention is directed to a method for improving learning and/or memory (e.g., auditory, visual, somatosensory or motor) in adults and children of an age which is beyond the early critical period for learning, said method comprising inhibiting (i) ecto-5′-nucleotidase (nt5e, aka cd73) or (ii) a1 adenosine receptor (a1r, aka adora1) expression or function in the brain. The invention is also directed to a method for treating learning and memory defects and neurological diseases associated with an abnormal auditory, visual, or somatosensory perception by inhibiting nt5e or a1r expression or function in the brain..
St. Jude Children's Research Hospital, Inc.

Point-and-click programming for deep brain stimulation using real-time monopolar review trendlines

A system and method for selecting leadwire stimulation parameters includes a processor iteratively performing, for each of a plurality of values for a particular stimulation parameter, each value corresponding to a respective current field: (a) shifting the current field longitudinally and/or rotationally to a respective plurality of locations about the leadwire; and (b) for each of the respective plurality of locations, obtaining clinical effect information regarding a respective stimulation of the patient tissue produced by the respective current field at the respective location; and displaying a graph plotting the clinical effect information against values for the particular stimulation parameter and locations about the leadwire, and/or based on the obtained clinical effect information, identifying an optimal combination of a selected value for the particular stimulation parameter and selected location about the leadwire at which to perform a stimulation using the selected value.. .
Boston Scientific Neuromodulation Corporation

Systems and methods for selective memory enhancement and/or disruption

Systems and methods are disclosed for selectively reinforcing or weakening memory associations. At least one current generator provides an electrical current including a plurality of oscillating pulses with at least one predetermined frequency.

Dry electrode

Disclosed is a dry electrode that electrically stimulates while contacting skin of a user, the dry electrode including a main body including a conductive body, and a nonconductive cover that surrounds the conductive body such that an area of the conductive body is exposed, and a patch detachably mounted on an area of the main body, in which the conductive body is exposed, one surface of the patch contacting the conductive body and an opposite surface of the patch contacting the skin of the user, the patch being configured to receive a current from the main body to electrically stimulate the skin of the user.. .
Y-brain Inc

Implantable intraventricular sampling and infusion access device

In some embodiments, a device may include an intraventricular access device and an infusion device. The intraventricular access device may include more than one catheter and a container.
Cerebral Therapeutics Llc

Peptides for assisting delivery across the blood brain barrier

The present invention provides compositions and methods useful for delivering agents to target cells or tissues, for example nerve cells and other cells in the central nervous system. The compositions and methods are useful for delivering agents across the blood-brain barrier.
Children's Medical Center Corporation

Rvg derived peptides

The invention relates to short rvg derived peptides for use in delivering therapeutic agents across the blood brain barrier and to target cells, for example those cells in the central nervous system. The invention provides method and compositions to treat diseases, such as neurodegenerative diseases, with therapeutic agents associated with targeting peptides..
United Arab Emirates University

Method for prolonging and enhancing anti-tumor vaccine response

A method for treating a tumor includes administering (i) a vaccine that contains stage-specific embryonic antigen 4 conjugated to a carrier, (ii) an antibody that binds specifically to ssea-4, and (iii) immune cells expressing a chimeric antigen receptor that specifically binds to ssea-4. The tumor, which expresses ssea-4, can be a breast, colon, gastrointestinal, kidney, lung, liver, ovarian, pancreatic, rectal, stomach, testicular, thymic, cervical, prostate, bladder, skin, nasopharyngeal, esophageal, oral, head and neck, bone, cartilage, muscle, lymph node, bone marrow, or brain tumor..

Methods of treating mild brain injury and post-traumatic stress disorder

The present disclosure provides methods for treating post-traumatic stress disorder (ptsd) and other neurological disorders in a subject, comprising administering to the subject an effective amount of a composition comprising ghrelin.. .
The Regents Of The University Of California

Method of inhibiting microglial cell migration and treating traumatic brain injury

Disclosed herein is a method of inhibiting microglial cell migration in the brain of a mammalian subject in need thereof, including subjects suffering from the symptoms of traumatic brain injury (tbi) and subjects suffering from a hematoma in the brain comprising administering an effective amount streptolysin o (slo) wherein microglial migration is inhibited providing therapeutic benefits to subjects suffering from diseases characterized by microglial cell migration and activation.. .
Beech Tree Labs, Inc.

Cns delivery of mrna and uses thereof

The present invention provides, among other things, methods and compositions for effective delivery of messenger rna (mrna) to the central nervous system (cns). In particular, the present invention provides methods and compositions for administering intrathecally to a subject in need of delivery a composition comprising an mrna encoding a protein, encapsulated within a liposome, such that the administering of the composition results in the intracellular delivery of mrna in neurons in the brain and/or spinal cord.
Translate Bio, Inc.

Brain-functional near infrared spectroscopy device and measurement method

Provided is a multi-channel brain-functional near infrared spectroscopy device capable of easily levelling detector noise. The following control is performed: setting transmittances of all of optical attenuators to 1, setting intensities of all of light sources to a maximum light intensity within a safe irradiation range; determining the effective illumination intensity of each light source probe i as well as a minimum effective illumination intensity and a maximum effective illumination intensity thereof; changing the transmittance ai of each optical attenuator i on the light source probe side to [the minimum effective illumination intensity/effective illumination intensity of each light source probe i], thereby levelling the effective illumination intensity; and increasing the intensities of all of the light sources by w=[the maximum effective illumination intensity/the minimum effective incident efficiency] times, and determining the effective detection rate of each detector probe j as well as the minimum effective detection rate thereof; and performing control so as to level the effective detection rate by changing the transmittance aj of each optical attenuator j on the detector probe side to [the minimum effective detection rate/effective detection rate of each detector probe j], thereby equalizing detector noise among all the channels k..
National Institute Of Advanced Industrial Science And Technology

Device to reduce traumatic brain injury

A device for reducing traumatic brain injury comprises a first sensor, a first linkage element, and a processing element. The first sensor is coupled to a head component and configured to measure an acceleration of a user's head and to generate a sequence of real-time measured samples.

Neurofeedback headgear for monitoring brain activity

A neurofeedback headgear is provided. The neurofeedback headgear comprises a head receiving portion, a brim portion, an eeg sensor assembly and an emitter.
Neuroservo Inc.

Interactive helmet system and method

An interactive helmet system and method for reducing brain injuries may provide a helmet and at least one inflatable air pouch. The at least one inflatable air pouch may remain in an active position and may pressurize or further inflate in response to an impact with a surface.
Joshua R&d Technologies, Llc

Systems and methods for monitoring of fractional gluconeogenesis and targeting of fractional gluconeogenesis via nutritional support

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“bes”) of a patient, are disclosed. The bes provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient.
Run Them Sweet Llc

Systems and methods for monitoring of blood lactate and targeting of blood lactate via nutritional support

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“bes”) of a patient, are disclosed. The bes provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient.
Run Them Sweet Llc

Sentinel Oncology Limited

. .

Method and system for analysing sound

The present invention relates to a method and system for analysing audio (eg. Music) tracks.
X-system Limited

Computing system and operating the computer system

The present disclosure provides a computing system, a method of operating the computing system, and a non-transitory tangible computer readable medium for providing cloud-computing services via a data communication network arrangement to one or more users. The computing system includes a data server arrangement for providing the cloud-computing services.
Adbrain Ltd

Quantifying mass effect deformation with structural radiomics in brain tumor patients

Methods and apparatus quantify mass effect deformation in diagnostic images of patients demonstrating glioblastoma multiforme (gbm). One example apparatus includes an image acquisition circuit that acquires an image of a region of tissue demonstrating gbm pathology, a delineation circuit that segments a tumor region from the image, a pre-processing circuit that generates a pre-processed image by pre-processing the segmented image, a registration circuit that registers the pre-processed image with a template image of a healthy brain, a deformation quantification circuit that computes a set of differences between a position of a brain sub-structure represented in the registered image relative to the position of the brain sub-structure represented in the template image.
Case Western Reserve University

Automatic 3d brain tumor segmentation and classification

A fully automatic brain tumor segmentation and classification method and system improve the healthcare experience with machine intelligence. The automatic brain tumor segmentation and classification method and system utilize whole tumor segmentation and multi-class tumor segmentation to provide accurate analysis..
Sony Corporation

A novel person identification and personality assessment based on eeg signal

The present invention relates a novel system and method for person identification and personality assessment based on electroencephalography (eeg) signal. More particularly, this invention relates to a novel method of eeg recording and processing to map the inherent and unique properties of brain in the form of highly specific brain signature to be used as means for person identification and personality assessment..

System and synchronizing identifiers associated with users

Disclosed is a method for synchronizing identifiers associated with a plurality of users. The method comprises receiving the data associated with a plurality of users, and thereafter integrating the data associated with the plurality of users and a pre-stored data of the identity management system in such a way to maximize the scale and quality of overall data.
Adbrain Ltd

Methods and compositions for diagnosing brain injury or neurodegeneration

Methods and compositions for diagnosing brain injury, neurodegeneration; or a predisposition thereto, in a subject are provided. Particularly, the present invention relates to specific antigen antibody reactivities useful in diagnosing brain injury, neurodegeneration or a predisposition thereto, in a subject..
Immunarray Usa, Inc.

Method for selection of agents influencing intestinal motility disorders and pain

A method is provided for evaluating agents for the treatment of different intestinal motility disorders, using distinct methodological parts related to musculature and nerves of the gi tract which communicate with the brain. In particular, the present invention provides a method for the selection of an agent effective for the treatment of an intestinal motility disorder, wherein said method comprises: a) a step of spatiotemporal (st) mapping carried out on a gastrointestinal segment to analyse the effect of said agent on gastrointestinal motility; and b) a step of ex vivo nerve bundle recording carried out on a gastrointestinal segment to analyse the effect of said agent on mesenteric afferent nerve firing.
Biogaia Ab

Modulators of the p70s6 kinase for use in the treatment of brain disorders and triple-negative breast cancer

And wherein, in each substituent consisting of or containing c1-4 hydrocarbyl, the c1-4 hydrocarbyl is selected from c1-4 alkyl, c2-4 alkenyl, c2-4 alkynyl, cyclopropyl, cyclobutyl and cyclopropylmethyl.. .

Compounds for stabilizing ryanodine receptors from aberrant levels of calcium release

Disclosed herein are methods and compositions comprising compounds capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods comprising these compounds for treating neuronal or neurological disorders, including alzheimer's disease, parkinson's disease, huntington's disease, fronto-temporal dementia, pick's disease, chronic traumatic encepholopathy, traumatic brain injury, stroke, cerebellar ataxia, multiple sclerosis, down syndrome, and aging-related cns disorders..
Rosalind Franklin University Of Medicine And Science

Novel methods, compounds, and compositions for anesthesia

Methods of treatment useful in the inducement or maintenance of anesthesia in a subject are provided. The methods comprise administering to a subject in need of anesthesia a compound disclosed herein.
The United States Government As Represented By The Department Of Veterans Affairs

Method and improving cognitive performance

A method for delivering electrical stimulation to alter a cognitive state of a user, the method comprising: monitoring a brain signal from the user via one or more intracranial electrodes implanted in the brain of the user while the user is presented with a stimulus; comparing the brain signal to a testing phase biomarker, wherein the testing phase biomarker is derived from a cognitive test performed on a contributor during a testing phase; delivering electrical stimulation to a brain of the user based on the comparing step to steer the brain of the user towards a high performance cognitive state.. .
The Trustees Of The University Of Pennsylvania

Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes

The present invention provides for compositions and methods for treating, ameliorating or preventing a lysosomal storage disease by administering to a patient suffering front a lysosomal storage disease a p97 conjugated with art enzyme which is capable of transportation into the lysosomes of cells on either sides of the blood brain barrier.. .
Bioasis Technologies, Inc.

Low molecular weight polyethylene glycol drug conjugates having improved drug biological activity

Provided are polyethylene glycol drug conjugates of general formula (i), (ii) or (iii) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules.
Jenkem Technology Co., Ltd. (tianjin)

Low molecular weight polyethylene glycol drug conjugates having improved drug biological activity

Provided are polyethylene glycol drug conjugates of general formula (i), (ii) or (iii) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules.
Jenkem Technology Co., Ltd. (tianjin)

Compositions for enhancing brain activity

C) a synergistic combination of (a) and (b).. .

Production of midbrain dopaminergic neurons and methods for the use thereof

Methods are provided for efficient production of midbrain dopaminergic (da) neurons. In some aspects, methods involve differentiation and selection of da neurons for a transgenic pluripotent cell population (e.g., cells comprising a selectable marker gene).
Cellular Dynamics International, Inc.

Bolaamphiphilic compounds, compositions and uses thereof

Where hg1, hg2 and l1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering biologically active drugs into animal or human brain..

Compounds and methods for treating neurological and cardiovascular conditions

The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.. .
The Board Of Regents Of The University Of Texas Sy

Methods of treating apoptosis and altering programmed cell death

In one aspect, a method of altering programmed cell death includes administering to an individual in need thereof a therapeutically effective amount of isomyosmine or a pharmaceutically acceptable salt thereof. In other aspects, isomyosmine is administered to treat a wound, hemochromatosis, traumatic brain injury, or disorders associated with chronic oxidative stress.
Mymd Pharmaceuticals, Inc.

Mebendazole polymorph for treatement and prevention of tumors

Mebendazole is an antiparasitic drug with over 40 years of safe use. Recently mebendazole was repurposed for glioblastoma therapy.
The Johns Hopkins University

Tissue-orientation-based simulation of deep brain stimulation

The present invention relates to a medical data processing method for determining an orientation of nerve fibres relative to a non-physiological electric field, the method comprising the following steps which are constituted to be executed by a computer: a) acquiring patient medical image data describing a patient medical image of an anatomical body part of a patient's body, the anatomical body part including nerve tissue comprising white matter nerve fibres; b) acquiring diffusion image data describing a diffusion-enhanced image of the anatomical body part; c) acquiring atlas data describing a spatial distribution of grey value-based tissue classes in a model body part representing a model of the anatomical body part; d) determining, based on the patient image data and the diffusion image data and the atlas data, fibre orientation data describing an orientation of the white matter nerve fibres; e) acquiring electric field orientation data describing an orientation of the non-physiological electric field which is an electric field simulated around a simulated electrode virtually placed in a predetermined spatial relationship relative to the anatomical body part; f) determining, based on the fibre orientation data and the electric field orientation data, relative orientation data describing a relative orientation between the orientation of the white matter nerve fibres and the orientation of the electric field.. .
Brainlab Ag

Methods and tools for diagnosing insulin resistance and assessing health status using nmr relaxation times for water

The subject invention pertains to a method that involves at least three steps: (1) acquisition of a nmr data set or spin relaxation curve for plasma, serum or whole blood samples, or for tissues monitored from outside the body, (2) analysis of the nmr data or relaxation curve to extract the t2 and/or t1 relaxation times for water (or surrogates thereof), and (3) conversion of the water t2 and/or t1 values (or surrogates thereof) into a measure of someone's health status (referred to as a t2 or t1 health score depending on the value (t1 or t2 or both t1 and t2) associated with the score). The t1 and/or t2 health score utilizes a statistical database derived from previous studies of subjects ranging from normal, healthy individuals to those having varying degrees of hidden or non-hidden metabolic abnormalities, such as inflammation, insulin resistance, lipid abnormalities (dyslipidemia), oxidative stress, brain abnormalities, cognitive impairment or other disorders, and provides a measure of a subject's overall metabolic and brain health status..
University Of North Texas Health Science Center At Fort Worth

Headgear with displaceable sensors for electrophysiology measurement and training

A method and system provides for headgear usable for electrophysiological data collection and analysis and neurostimulation/neuromodulation or brain computer interface for clinical, peak performance, or neurogaming and neuromodulation applications. The headgear utilizes dry sensor technology as well as connection points for adjustable placement of the bi-directional sensors for the recoding of electrophysiology from the user and delivery of current to the sensors intended to improve or alter electrophysiology parameters.
Evoke Neuroscience, Inc.

Enebrain Co., Ltd.

. .

Auto-calibration of probabilistic tracking parameters for dti fibre tractography and compilation of tract probability comparison scales

1. A medical data processing method of determining information describing the probable position of a neural fibre in a patient's brain, the method comprising the following steps which are constituted to be executed by a computer: a) acquiring patient-specific medical image data describing the brain of the patient; b) acquiring atlas data defining an image-based model of a human brain; c) determining, based on the patient-specific medical image data and the atlas data, seed region data describing seed regions (a, b) in the patient-specific medical image data in which the ends of neural fibres of the patient's brain may be located; d) determining, based on the patient-specific medical image data and the seed region data, neural fibre tract data describing a plurality of potential tracts (t1, t2, t3) which a specific neural fibre may take through the patient's brain; e) determining, based on the atlas data and the neural fibre tract data, a figure of merit for each one of the potential tracts (t1, t2, t3)..
Brainlab Ag

Method and constructing a neuroscience-inspired artificial neural network with visualization of neural pathways

A method and apparatus for constructing one of a neuroscience-inspired artificial neural network and a neural network array comprises one of a neuroscience-inspired dynamic architecture, a dynamic artificial neural network array and a neural network array of electrodes associated with neural tissue such as a brain, the method and apparatus having a special purpose display processor. The special purpose display processor outputs a display over a period of selected reference time units to demonstrate a neural pathway from, for example, one or a plurality of input neurons through intermediate destination neurons to an output neuron in three-dimensional space.
University Of Tennessee Research Foundation

Data view system for computer network management

A gui system for accessing and displaying computer network data dynamically. Network data regarding network devices and interfaces are typed into different categories.
Netbrain Technologies, Inc.

Bk channel-modulating peptides and their use

The present invention concerns peptides and nucleic acids encoding the peptides, and their use for modulating large conductance ca2+ activated k+ (bk) channel activity in cells; for treating conditions such as presbycusis (age-related hearing loss), audiogenic seizures, alcohol addiction, cancer, and neurodegenerative disease; and for delivering a cargo moiety to the brain of a subject through the blood-brain barrier.. .
Board Of Regents, The University Of Texas System

Method, system and non-invasive neurostimulation therapy of the brain

The present invention is a portable non-invasive system, apparatus and method for performing light therapy or photobiomodulation upon the brain tissues through the skull and/or nostrils of a living mammalian subject for the medical purpose of stimulating the brain in-vivo. The present invention utilizes the transcranial and/or intranasal pathways as points of anatomic access and follows established principles for the conceptual approach that irradiation of the brain tissue with low level light energy of certain fixed parameters would achieve major therapeutic effects in-vivo..

Optogenetic control of endothelial cells

The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to transport therapeutics across the vascular barrier into tissues such as the brain and the lung, with high spatial and temporal precision, and for controlling vascular properties such as vascular tone, arterial diameter, and vascular growth..
Massachusetts Institute Of Technology

Neurostimulation using ac and/or dc stimulation pulses

Neurostimulation is performed using electrical ac and/or dc stimulation pulses. Brain and/or spinal cord stimulation of a patient is achieved using an implanted neurostimulation device.
Precisis Ag

Catheter and guide tube for intracerebral application

A catheter for use in neurosurgery, and a method of positioning neurosurgical apparatus. The catheter has a fine tube arranged for insertion into the brain parenchyma of a patient with an external diameter of not more than 1.0 mm.
Renishaw (ireland) Limited

Engineered receptor/ligand system for delivery of therapeutic agents

Provided herein are compositions and methods related to targeted delivery of a therapeutic or diagnostic agent to a subject utilizing an engineered receptor-ligand system, such as an engineered dockerin-cohesin system. As described herein, previously-developed targeted delivery systems for delivering therapeutic and diagnostic agents to a tissue of interest have drawbacks that have not been addressed to date.
University Of Florida Research Foundation, Inc.

Therapeutic intervention guidance system for atopic eczema and a providing therapeutic intervention guidance

A therapeutic intervention guidance system for atopic eczema includes a device measuring a skin surface moisture level and a trans-epidermal water loss (tewl) value of a subject, a process comparing the skin surface moisture level and the tewl value with a predetermined level and value, and an outcome providing a therapeutic intervention guidance based on the comparison. A method of providing therapeutic intervention guidance for atopic eczema includes measuring a skin surface moisture level and a trans-epidermal water loss (tewl) value of a subject, comparing the skin surface moisture level and the tewl value with a predetermined level and value, and providing a therapeutic intervention guidance based on the comparison..
Sphingobrain Co. Ltd.

Pharmaceutical composition for inhibiting growth of cancer stem cells, containing aldehyde inhibitor and biguanide-based compound

The present invention relates to a pharmaceutical composition for inhibiting growth of cancer stem cells, containing an aldehyde inhibitor and a biguanide-based compound. The pharmaceutical composition according to the present invention contains a combination of an aldehyde inhibitor and a biguanide-based compound, which can effectively inhibit the growth of cancer stem cells such as neurospheres and can also inhibit the proliferation, invasion and metastasis of cancer cells, thereby preventing and/or treating cancer such as brain cancer..
National Cancer Center

Robot for minimally invasive neurosurgery

A robotic device for performing intracranial procedures, comprising a baseplate for mounting on the subject's skull and a rotatable base element rotating on the baseplate. The rotatable base element has a central opening through which a cannulated needle can protrude such that it can rotate around an axis perpendicular to the baseplate.
Technion Research & Development Foundation Ltd.

Early diagnosis and treatment of alzheimer disease and mild cognitive impairment

Methods, systems and devices for detecting and treating cognitive impairment conditions by inducing stimulation to a predetermined region of the brain and measuring neural activity response to the stimulation and evaluating a neuroplasticity of neural-structures in a predetermined brain region, then stimulating the predetermined brain region to treat the cognitive impairment condition.. .
Nibs Neuroscience Technologies Ltd.

System and method to assess risk of changes to brain white matter based on head impact dose equivalent number

A system to assess risk of changes to brain white matter includes a sensor system adapted to measure an energy of each impact to an individual belonging to a sub-population that causes a repetitive head impact (rhi). A head impact dose equivalent number (hiden) process calculates a hiden for a most recent rhi event based on the energy of the most recent rhi event, a time of the most recent rhi, and all previously recorded rhi events available in a non-volatile memory.
University Of Rochester

Wearable physiological monitoring device

The present invention discloses a wearable physiological monitoring device for providing brain activity information and deciding a breathing guiding signal in a neurofeedback section, for being a basis for a user to perform a self-regulation about brain function. The device includes a wearable structure for mounting plural eeg electrodes and/or optical sensor on the head and/or an ear of the user so as to obtain information about brain activity and respiratory behavior..

Hearing assistance system comprising an eeg-recording and analysis system

A hearing assistance system comprises an input unit for providing electric input sound signals ui, each representing sound signals ui from a multitude nu of sound sources si, an electroencephalography (eeg) system for recording activity of the auditory system of the user's brain and providing a multitude ny of eeg signals yj, and a source selection processing unit receiving said electric input sound signals ui and said eeg signals yj, and in dependence thereof configured to provide a source selection signal Ŝx indicative of the sound source sx that the user currently pays attention to using a selective algorithm that determines a sparse model to select the most relevant eeg electrodes and time intervals based on minimizing a cost function measuring the correlation between the individual sound sources and the eeg signals, and to determine the source selection signal Ŝx based on the cost functions obtained for said multitude of sound sources.. .
Oticon A/s

Methods for improved measurements of brain volume and changes in brain volume

Methods of the disclosure may include obtaining a first set of medical images at a first time point and a second set of medical images at a second time point, each set including at least two medical images. First and second algorithms may be used to calculate, respectively, first and third brain volume (bv) values at the first time point based on two or more images from the first set of medical images and second and fourth bv values at the second time point based on two or more images from the second set of medical images.
Biogen Ma Inc.

Method and system for providing a brain computer interface

A method for providing a brain computer interface that includes detecting a neural signal of a user in response to a calibration session having a time-locked component and a spontaneous component; generating a user-specific calibration model based on the neural signal; prompting the user to undergo a verification session, the verification session having a time-locked component and a spontaneous component; detecting a neural signal contemporaneously with delivery of the verification session; generating an output of the user-specific calibration model from the neural signal; based upon a comparison operation between processed outputs, determining an authentication status of the user; and performing an authenticated action.. .
Arctop, Inc.

Methods and apparatuses for determining head movement

The present application discloses various methods and apparatuses for determining a head movement, wherein a method for determining a head movement disclosed comprises: acquiring, in response to a head movement of a human body, brain electricity detection information of a human body; and determining the head movement corresponding to the brain electricity detection information. The present application provides a new solution for head movement recognition, by which accuracy of head movement recognition is improved..
Beijing Zhigu Rui Tuo Tech Co., Ltd.

Use of an anti-alpha-synuclein antibody to diagnose an elevated level of alpha-synuclein in the brain

This disclosure relates to the use of anti-α-synuclein antibody to diagnose an elevated level of α-synuclein in the brain. Specifically, the disclosure relates to the method of assessing the levels of α-synuclein in a blood plasma or csf following administration to the test subject of an anti-α-synuclein antibody or antigen-binding fragment thereof, which can bind α-synuclein with sufficient activity to alter the net efflux of α-synuclein from brain to blood, or from brain to csf..
Biogen International Neuroscience Gmbh

Monoclonal antibody for the diagnosis, treatment and/or prevention of brain tumors and brain lesions

The invention relates to the use of the monoclonal antibody nilo1 for the diagnosis, treatment and/or prevention of brain tumors and lesions. Particularly, the invention relates to methods for the diagnosis of brain tumors and brain lesions in which cells marked with said antibody, or with immunologically active fragments thereof, are detected.
Consejo Superior De Investigaciones Cientificas (csic)

Editing profiling of pde8a pre -mrna: use as specific biomarker of adars activities in human tissues to diagnose and to predict and assess therapeutic efficacy and/or efficiency or potential drug side effects

The present invention relates to the use of the editing profile of pde8a pre-mrna as a specific bio marker of adars activities in evolved primate, particularly in human tissues. The present invention also relates to an in vitro method for predicting in human an alteration of the mechanism of the adars catalysed pre-mrna editing of target genes, by analysing the pde8a pre-mrna editing profile in a peripheral tissue sample containing cells expressing said pde8a pre-mrna, such as blood sample.
Alcediag

Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof

The present invention relates to methods of generating and expanding hitman embryonic stem cell derived mesenchymal-like stem/stromal cells. These hes-mscs are characterized at least in part by the low level of expression of il-6.
Imstem Biotechnology, Inc.

A direct conversion human fibroblasts into neural stem cells using small molecules

The present invention relates to a method of converting human fibroblasts into neural stem cells, and more particularly, to a method of directly converting human fibroblasts into neural stem cells using only a combination of small-molecule compounds without any introduction of a foreign gene, and to the use of the neural stem cells. The method of directly converting human fibroblasts into neural stem cells using only small-molecule compounds without any introduction of a foreign gene makes it possible to obtain genetically stable neural stem cells in an amount sufficient for use in cell therapy by deriving them from human fibroblasts.
Korea University Research And Business Foundation

Antibodies against p97 and conjugates thereof

Provided are conjugates between (a) an antibody or antigen-binding fragment thereof that binds to p97 (melanotransferrin; mtf) and (b) an agent of interest, and related compositions and methods, for example, to improve pharmacokinetics and/or delivery of the agent of interest across the blood-brain barrier (bbb) and into tissues of the central nervous system (cns).. .
Bioasis Technologies, Inc.

Antibody molecules and peptide delivery systems for use in alzheimer's disease and related disorders

The present invention relates to antibody molecules and peptide delivery systems for use in the treatment and management of alzheimer's disease and related disorders. In particular, the antibody molecules preferentially bind oligomeric forms of beta-amyloid peptide, in single domain format, and the peptide delivery systems facilitate specific transport of such antibody molecules, as well as other cargo molecules, across the blood-brain barrier.
Technophage, InvestigaÇÃo E Desenvolvimento Em Biotecnologia, S.a.

Fusion protein comprising leptin and methods for producing and using the same

The present invention provides fusion proteins comprising leptin and a second protein. The presence of the second protein provides increased biological activity and/or increased half-life in vivo.
Askgene Pharma, Inc.

Diagnosis and treatment of chronic pain

Methods, systems and devices for treating chronic pain by inducing stimulation to a predetermined region of the brain and measuring neural activity response to the stimulation and evaluating a neuroplasticity and/or excitability of neural-structures in a predetermined brain region, then stimulating the predetermined brain region to treat the chronic pain.. .
Nibs Neuroscience Technologies Ltd.

Prolonged anti-diabetic effect of fibroblast growth factor 1 (fgf1)

Disclosed are compositions and methods for inducing sustained diabetes remission by single administration of fgf1 to the brain. The composition and methods described herein result in basal glucose clearance by using a dosage of fgf1 that is lower than that needed for systemic efficacy and is devoid of the risk of hypoglycemia and changes in body weight, food intake, hepatic glucose production, insulin secretion or insulin sensitivity..
University Of Washington

Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment

A method for the treatment of a neurodegenerative, psychiatric or neurological disease associated with a cholinergic deficit comprising administering gln-1062 or a pharmaceutically acceptable salt thereof by nasal administration to a patient in need thereof.. .
Neurodyn Life Sciences Inc.

System of joint brain tumor and cortex reconstruction

System for performing fully automatic brain tumor and tumor-aware cortex reconstructions upon receiving multi-modal mri data (t1, t1c, t2, t2-flair). The system outputs imaging which delineates distinctions between tumors (including tumor edema, and tumor active core), from white matter and gray matter surfaces.
Sony Corporation

Method to exercise eyes, hands and feet coordination

As depicted in figs. 1-7, the eye detects that the foot is slower than the hand and the information is sent immediately from the eye to the brain.

Method for detecting hematoma, portable detection and discrimination device and related systems and apparatuses

Featured are methods, apparatus and devices for detecting a hematoma in tissue of a patient. In one aspect, such a method includes emitting near infrared light continuously into the tissue from a non-stationary near infrared light emitter and continuously monitoring the tissue using a non-stationary probe so as to continuously detect reflected light.
The Henry M. Jackson Foundation For The Advancemen Of Military Medicine, Inc.

Dual eeg non-contact monitor with personal eeg monitor for concurrent brain monitoring and communication

Aspects of the disclosure can provide a method and device for detecting eeg signals of a first person in proximity to the device. The device can include a non-contact eeg directional circuit having non-contact sensors, the non-contact eeg directional circuit being configured to detect the eeg signals produced by a brain of the first person without making contact with the first person.
Freer Logic, Inc.

Immunotherapy for clearing pathological tau conformers

The present invention relates to methods of treating and preventing alzheimer's disease or other tauopathies in a subject by administering a tau protein, its immunogenic epitopes, or antibodies recognizing the tau protein or its immunogenic epitopes under conditions effective to treat or prevent alzheimer's disease of other tauopathies. Also disclosed are methods of promoting clearance of from the brain of the subject and of slowing progression of tangle-related behavioral phenotype in a subject..
New York University

Graphene membrane film for solvent purification, producing same, and solvent purification system using same

Described embodiments include a graphene membrane film for solvent purification and related method, and a solvent purification system using same. The graphene membrane film for solvent purification is formed having a plurality of stacked graphene plate-shaped flakes, and at least one pair of the plurality of stacked graphene plate-shaped flakes comprises a physical bond or a chemical bond connecting layers.
Soulbrain Co., Ltd.

Device for non-invasive neuro-stimulation by means of multichannel bursts

A device is provided for the stimulation of neurons that includes a non-invasive stimulation unit to generate stimuli in multiple stimulation channels, where the stimulation unit stimulates a neuron population in the brain and/or spinal cord of a patient in different locations for each of the stimulation channels. Moreover, the device includes a control unit that controls the stimulation unit to generate repetitive bursts in each of the stimulation channels, where each of the bursts includes multiple stimuli and is designed so that they do not reset the phase of the neuronal activity of the respective stimulated neurons..
Forschungszentrum Juelich Gmbh

Blood brain barrier receptor antibodies and methods of use

The present invention relates to antibodies that bind to receptors expressed on the blood brain barrier and methods of using the same.. .
Genentech, Inc.

Methods and compositions for treating brain diseases

The present disclosure provides methods for treating or preventing huntington's disease (hd) in a subject in need thereof, comprising administering a therapeutic agent that activates mtorc 1 function and/or increases ras homolog enriched in striatum (rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment, and methods for modulating mhtt-associated metabolic phenotypes and/or reversal of striatal atrophy by administering a therapeutic agent that activates mtorc1 function and/or increases ras homolog enriched in striatum (rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment.. .
University Of Iowa Research Foundation

Method for treatment of internal disorders via activation of dermatomal nervous receptors

A system and method for treating neural lesions is disclosed. The inventive method comprises determining the location of a neural lesion in a patient and applying a selected modality to a dermatomal region on the patient to compensate for the existence of the neural lesion.

Image processing apparatus, image processing method, and program

An image processing device includes: an image data acquisition unit for acquiring spect image data of a brain; a brain-region roi definition unit for defining a brain-region roi in the spect image; a striatum roi definition unit for defining a striatum roi in the spect image; and a threshold determination unit for, based on counts in the spect image's background which is the brain-region roi except the striatum roi, determining a threshold for distinguishing ventricles and sulci in the spect image; a region distinction unit for distinguishing between a region whose number of counts is smaller than or equal to the threshold and a region whose number of counts is larger than the threshold.. .
Nihon Medi-physics Co., Ltd.

Devices which prompt diverse brain states to upgrade brain performance

An electronic device that includes an electronic calendar containing scheduled events, the device further including a) software that matches an event with an optimal brain state, and b) means for convening to the user of the device such optimal brain state when the calendar indicates that the event is imminent or has arrived.. .

Insertion of medical devices through non-orthogonal and orthogonal trajectories within the cranium and methods of using

The invention comprises an elongated device adapted for insertion, including self-insertion, through the body, especially the skull. The device has at least one effector or sensor and is configured to permit implantation of multiple functional components through a single entry site into the skull by directing the components at different angles.

Prediction of preictal state and seizure onset zones based on high frequency oscillations

A seizure preemption system including electrodes for recording simultaneous electroencephalographic (eeg) signals from a subject, a controller electrically coupled to the electrodes, and a neuromodulator electrically coupled to the controller. The controller is configured to sample the simultaneous eeg signals, identify high frequency oscillation (hfo) events in each eeg signal, and extract one or more features from each eeg signal to yield hfo profiles for the hfos recorded from each eeg signal.
Seton Healthcare Family

Vibrating footwear device and entertainment system for use therewith

Methods of enhancing a sensory experience to simulate a live event are provided. One includes providing an audible signal representing sound information; generating a vibration signal based on the audible signal and enhanced information that would be present at the live event; and providing the vibration signal to at least one vibration device for stimulating nerve receptors in a foot area, the vibration signal synchronized with the audible signal to produce a perception in the brain of being present at the live event.
Sonicsensory, Inc.