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Blood patents

      

This page is updated frequently with new Blood-related patent applications.

Method and devices for flow occlusion during device exchanges
A method of reducing the risk of clinical sequelae to catheter induced vascular injuries may include introducing a guide wire into a vascular sheath residing in a blood vessel, proximally retracting the vascular sheath while leaving the wire in place, and observing indicia of the presence or absence of a vascular injury caused to the blood vessel by the vascular sheath or a procedural catheter previously advanced through the vascular sheath. If indicia of a vascular injury are observed, the method may further involve proximally retracting the guide wire to position the inflatable balloon adjacent the injury and inflating the balloon to reduce blood flow past the injury, while leaving the guide wire in place to provide subsequent access to the injury.
Lazzeri Societa Agricola A R.l.


Dynamic analysis apparatus and dynamic analysis system
A dynamic analysis apparatus may include a setting section which sets a target region in a lung region of a chest dynamic image; a conversion section which calculates a representative value of a pixel signal value in the target region, and converts the pixel signal value; an extraction section which extracts a pulmonary blood flow signal from the image; and a calculation section which calculates a change in the pulmonary blood flow signal, and calculates a feature amount regarding pulmonary blood flow. The setting section may determine a size of the target region based on a size of a body part other than a lung blood vessel, a movement amount of a body part other than the lung blood vessel or subject information of the chest dynamic image, the subject information regarding a subject of the radiation imaging, and the setting section may set the target region..
Konica Minolta, Inc.


Decentralized competitive arbitration using digital ledgering
Disclosed techniques enable arbitration of electronic competitions using digital ledgering. A digital competition arbitration platform is based on secure, trusted digital ledgering techniques.
Firstblood Technologies, Inc.


Methods and systems for metabolite and/or lipid-based detection of colorectal cancer and/or adenomatous polyps
Described herein are sets of metabolite and lipid (e.g., fatty acid) markers that can be used in the detection of early stage colorectal cancer and/or early development of adenomatous polyps. Presented herein are illustrative pathology-linked panels.
Universal Diagnostics, S.l.


Immunoassay for free vitamin d
Disclosed is the invention to conduct immuno-adsorption of free 25(oh) vitamin d from blood or blood components, notably serum or plasma, after which the absorbed material is measured. A fluoro-alkyl surfactant is used to enhance the solubility of vitamin d and allow the measurement of free vitamin d.
Future Diagnostics B.v.


Immature platelet enumeration systems and methods
Embodiments of the present invention encompass automated systems and methods for analyzing immature platelet parameters in an individual based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (dc) impedance, radiofrequency (rf) conductivity, and/or light measurement data obtained from the biological sample with an evaluation of immature platelet conditions in the individual..
Beckman Coulter, Inc.


Method of estimating blood volume
Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. The method and devices include the use of a rbc flocculant, such as polydadmac, and an approximate blood hematocrit for the type of animal, as well as a calculated rbc packing ratio corresponding to the collection device being used.
Hemodus Medical, Llc


Apparatus and separating and concentrating fluids containing multiple components
An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus.
Biomet Biologics, Llc


Clot mitigating probe for blood analyzing instrument
Aspects of the present disclosure include a titration probe that mitigate the occurrences of titration probe clots. A bar such as segment of music wire, is extended across the tip of a titration probe and attached at both ends to the titration probe.
Instrumentation Laboratory Company


Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity
Methods for determining the hematocrit of a blood sample, and devices and systems used in conjunction with the same. The hematocrit value can be determined on its own, and further, it can be further used to determine a concentration of an analyte in a sample.
Lifescan, Inc.


16s ribosomal rna universal primers and use thereof in microbiological analysis and diagnostics

The subject-matter of the invention is a pair of primers, a method of microbiological analysis of biomaterial, application of ngs sequencing method in microbiological diagnostics of blood and diganostics set. An innovative method of body fluids diagnosing from microbiological perspective i.e.
Uniwersytet Jagiellonski

Method and system for isolating adipose-derived stem cells

The present invention refers to a non-invasive method for isolating adipose-derived stem cells from adipose tissue by illuminating the adipose tissue with at least one laser having a wavelength of between 360 nm to 480 nm or between 800 nm to 2 pm for a predetermined time for dissociating fat cells and blood vessels of the adipose tissue to release intact stem cells from the adipose tissue while maintaining the viability of the stem cells. In the preferred embodiment, the adipose tissue is illuminated with pulsed near infra-red (nir) laser and a continuous wave (cw) diode blue laser.
Agency For Science, Technology And Research

Methods and compositions for treating ulcers

The present disclosure provides compositions and methods for treating or preventing ulcers in subjects having low red blood cell levels and/or hemoglobin levels (e.g, anemia). In some embodiments, the compositions of the disclosure may be used to treat or prevent ulcers associated with anemia..
Acceleron Pharma Inc.

Systems and methods for treatment of fluid overload

Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system.
White Swell Medical Ltd

Systems and methods for treatment of fluid overload

Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system.
White Swell Medical Ltd

Assist device for sclerosing treatment of varicose veins

Assist device (10) for sclerosing treatment of varicose veins, aimed at being partially inserted into a blood vessel (20), including a tubular element (11), which has at least three ways (13, 14, 15), at least two of which (13, 14) are connected to at least one related inflatable balloon element (12, 12′, 16) by at least one through hole (30, 31), and at least one remaining way (15) of said three ways (13, 14, 15) has at least one hole (32) for the passage of a sclerosing substance (17), aimed at reaching a wall (18) of said blood vessel (20), in which at least one (16) of said at least two balloon elements (12, 12′, 16) has an elongated shape extending toward at least another balloon element (12, 12′) and a volume comprised in the range of 30% to 99% of the space inside said blood vessel.. .
I-vasc S.r.l.

Catheter systems and packaged kits for dual layer guide tubes

A catheter-based/intravascular ablation (denervation) system includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic or/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable needle delivery system is formed with self-expanding materials and include structures, near the end portion of the needles, or using separate guide tubes.
Ablative Solutions, Inc.

Baloonless endotracheal tube

Endotracheal tubes with balloons (cuffed) deform the circulation of air by applying pressure on the walls of the trachea and cause numerous complications. In the endotracheal tube analyzed in the invention, the valve system in the form of flexible membrane is used instead of balloons, during each expiration, the pressure on the trachea wall is decreased and the disorder of getting blood occurring in the mucosa of the trachea was prevented.

Single use delivery device

The invention is a single use delivery device capable of delivery of an agent (e.g., vaccine, drug, medicament, etc.) in a controlled manner and without requiring specialized skill in administering delivery of such agent. The delivery device is configured to be filled on-site and in the field with a dose of an agent, while remaining sterile and preventing the potential for contamination during the filling process.

Single use delivery device having safety features

The invention is a single use delivery device capable of delivery of an agent (e.g., vaccine, drug, medicament, etc.) in a controlled manner and without requiring specialized skill in administering delivery of such agent. The delivery device is configured to be filled on-site and in the field with a dose of an agent, while remaining sterile and preventing the potential for contamination during the filling process.

Single use delivery device prefilled with a reconstitutable agent

The invention is a single use delivery device configured to enable reconstitution of a lyophilized agent (e.g., vaccine, drug, medicament, etc.) stored within for subsequent delivery of the reconstituted fluid agent to a patient in a controlled manner and without requiring specialized skill in reconstituting the agent or administering delivery of such agent. The delivery device is prefilled with an individual dose of a lyophilized agent and configured to be filled on-site and in the field with a dose of diluent for reconstitution of the lyophilized agent, while remaining sterile and preventing the potential for contamination during the filling process.

Fluid management system and methods

A hysteroscopic fluid management system includes a saline source with an electrolyte concentration, at least one pressure mechanism for circulating saline to and from a targeted site and through a filter having filter characteristics back to the source, and a controller. The controller provides a saline inflow in a first flow path to the site and a saline outflow in a second flow path from the site through the filter and back to the source at a controlled flow rate.
Boston Scientific Scimed, Inc.

Antithrombogenic hollow fiber membranes and filters

The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses..
Interface Biologics, Inc.

Process feature graphical elements for medical treatment user interfaces

Graphical user interfaces for use with extracorporeal blood treatment systems may include one or more process feature graphical elements. The process feature graphical elements may be moved automatically or manually by users to provide indications with respect to the process features associated with and represented by the process feature graphical elements..
Gambro Lundia Ab

Apparatus for determining a parameter indicative of the progress of an extracorporeal blood treatment

An apparatus for extracorporeal treatment of blood (1) comprising a treatment unit, a blood withdrawal line, a blood return line, a preparation line and a spent dialysate line. A control unit (10) is configured to calculate values of a parameter relating to treatment effectiveness based on measures of the conductivity in the spent dialysate line.
Gambro Lundia Ab

Treatment solution delivery in an extracorporeal blood treatment apparatus

Blood treatment apparatus and methods of using the same are described herein that include two or more intermediate containers located between a treatment solution source and a port through which the treatment solution is to be delivered with the blood treatment apparatus. The weight of the intermediate containers is measured and used to control the refilling and emptying of treatment solution in the intermediate containers..
Gambro Lundia Ab

Implantable intravascular ventricular assist device

The present disclosure provides intravascular ventricular assist devices for insertion into the vasculature of an individual to improve the overall blood flow of the individual. In many embodiments, the intravascular ventricular assist devices described herein provide an individual with an intravascular ventricular assist device that is sized and configured for insertion into an aortic root or pulmonary root such that its reduced size and placement provide the individual with an improved quality of life.

Printable morphogenetic phase-specific chitosan-calcium-polyphosphate scaffold for bone repair

This invention concerns a formula for the synthesis of a printable hybrid material, formed of carboxymethyl chitosan (cmc) and polyphosphate (polyp). Both polymers are linked together by calcium ions.

Nanoconjugates able to cross the blood-brain barrier

Polyvalent nanoconjugates address the critical challenges in therapeutic use. The single-entity, targeted therapeutic is able to cross the blood-brain barrier (bbb) and is thus effective in the treatment of central nervous system (cns) disorders.
Northwestern University

Products and methods for delivery of polynucleotides by adeno-associated virus for lysosomal storage disorders

The present invention relates to methods and materials useful for systemically delivering polynucleotides across the blood brain barrier using adeno-associated virus as a vector. For example, the present invention relates to methods and materials useful for systemically delivering α-n-acetylglucosamidinase polynucleotides to the central and peripheral nervous systems, as well as the somatic system.
Nationwide Children's Hospital, Inc

Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the gi tract. Many embodiments provide a swallowable device for delivering the agents.
Rani Therapeutics, Llc

Mutated fibroblast growth factor (fgf) 1 and methods of use

The present disclosure provides fgf1 mutant proteins, such as those having an n-terminal deletion, point mutation(s), or combinations thereof, which can reduce blood glucose in a mammal. Such mutant fgf1 proteins can be part of a chimeric protein that includes a β-klotho-binding protein, an fgfr1c-binding protein, a β-klotho-binding protein and a fgfr1c-binding protein, a c-terminal region from fgf19 or fgf21.
Salk Institute For Biological Studies

Angiotensin ii alone or in combination for the treatment of hypotension

The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin ii which is effective to raise the blood pressure of the subject to a mean arterial pressure (map) of about 65 mm hg or above, and which is effective to reduce the dose of the catecholamine required to maintain a map of about 65 mm hg to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.. .
The George Washington University A Congressionally Chartered Not-for-profit Corporation

Bioeffective krill oil compositions

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and/or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process.
Aker Biomarine Antarctic As

Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment

A method of generating an isolated population of cells comprising anti-third party cells having a central memory t-lymphocyte (tcm) phenotype, the cells being tolerance-inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) contacting peripheral blood mononuclear cells (pbmc) with a third party antigen or antigens in the presence of il-21 so as to allow enrichment of antigen reactive cells; and (b) culturing the cells resulting from step (a) in the presence of il-21, il-15 and il-7 in an antigen free environment so as to allow proliferation of cells comprising the central memory t-lymphocyte (tcm) phenotype..
Yeda Research And Development Co. Ltd.

Stem cell culture media and methods of enhancing cell survival

The invention provides improved methods for preparing hematopoietic cells for transplantation and the resulting improved hematopoietic cell compositions. The invention further relates to improved culture media and methods of culturing, processing, modulating, and expanding blood cell products for hematopoietic transplantation..
Fate Therapeutics, Inc.

Potassium-binding agents for treating hypertension and hyperkalemia

The present invention generally relates to methods of treating hypertension (htn) in patients in need thereof wherein the patient optionally further suffers from chronic kidney disease (ckd) or type ii diabetes mellitus (t2dm). The invention also relates to methods of treating hyperkalemia in a patient in need thereof, wherein the patient suffers from ckd, t2dm or htn and are optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (raas) agent.
Relypsa, Inc.

Gut anti-inflammatory agents for regulation of high blood glucose levels

A method of treating high blood glucose levels is disclosed. The method includes administering gut anti-inflammatory agents such as mesalamine (5-aminosalicylic acid), sulfasalazine, asacol, delzicol, pentasa, lialda, apriso, olsalazine, balsalazide and ged-0507-34, or pharmaceutically acceptable salts, solvates, or esters of any of the foregoing.
University Health Network

Compositions and methods using same for delivering agents into a target organ protected by a blood barrier

A method of delivering a pharmaceutical agent into a target organ protected by a blood barrier is provided. The method comprising administering to a subject in need thereof an amount of liposomes which comprise the pharmaceutical agent, the amount and the liposomes are selected such that the liposomes accumulate in cells of an immune system of the subject to thereby generate liposome loaded immune cells, the liposome loaded immune cells become activated and cross the blood barrier, and an effective amount of the pharmaceutical agent is released from the liposomes in the target organ of the subject..
Biorest Ltd.

Device and ablative cutting with helical tip

Catheter devices for ablation and removal of occlusions from blood vessels and methods of using the same are provided. Catheter devices are useful to ablate, cut, dislodge, and otherwise remove occlusions within a blood vessel that may limit or prevent proper circulation.
The Spectranetics Corporation

Devices and methods for treating vascular occlusion

Systems and methods for removal of thrombus from a blood vessel in a body of a patient are disclosed herein. The method can include: providing a thrombus extraction device including a proximal self-expanding member formed of a fenestrated structure, a substantially cylindrical portion formed of a net-like filament mesh structure having a proximal end coupled to a distal end of the fenestrated structure; advancing a catheter constraining the thrombus extraction device through a vascular thrombus, deploying the thrombus extraction device by stacking a portion of the net-like filament mesh structure outside of the catheter by distally advancing the self-expanding member until the self-expanding member is beyond a distal end of the catheter; retracting the self-expanding member to unstack the portion of the net-like filament mesh structure and to capture the portion of the thrombus; and withdrawing the thrombus extraction device from the body..
Inari Medical, Inc.

Hemostatic method

A hemostatic method is performed as follows: a) an at-puncture hemostatic pressure is applied to a puncture in a blood vessel via a main geometric side, and at least one off-puncture hemostatic pressure is applied to at least one position away from the puncture via at least one auxiliary geometric side, wherein the off-puncture hemostatic pressure acts on the blood vessel either directly or indirectly. B) during the hemostatic process, an ongoing flow velocity of the blood in the blood vessel is obtained and is reduced to lower than a normal flow velocity in the blood vessel by applying the at-puncture and off-puncture hemostatic pressures simultaneously, wherein the at-puncture and off-puncture hemostatic pressures are lower than a systolic pressure in the blood vessel..
Southern Taiwan University Of Science And Technology

Personalized tourniquet for intermittent vascular occlusion

An apparatus for intermittent vascular occlusion based on a personalized tourniquet pressure (ptp) includes a dual-purpose tourniquet cuff having an inflatable bladder, a sensor module having a pulsation sensor communicating pneumatically with the inflatable bladder for sensing and characterizing pressure pulsations indicative of a distal occlusion pressure (dop) to identify a minimum pressure at which penetration of blood past the cuff is stopped, a ptp estimator responsive to the pulsation sensor for producing an estimate of a ptp, wherein the estimate of the ptp is a function of the dop, an effector module communicating pneumatically with the inflatable bladder for maintaining pressure in the bladder near the ptp during a first time period and for maintaining pressure in the bladder near a second level of pressure during a second time period, and a controller selectively operating the inflatable bladder in conjunction with the sensor module and the effector module.. .
Western Clinical Engineering Ltd.

Control device of ultrasonic diagnostic apparatus, ultrasonic diagnostic apparatus, clutter component reducing method

A control device of an ultrasonic diagnostic apparatus includes a detector that detects a doppler signal from a reception signal based on a reflected ultrasonic wave reflected on an internal portion of a subject, and a clutter component reducer that acquires a frequency spectrum based on the doppler signal and reduces a clutter component from the acquired frequency spectrum based on symmetry of the clutter component which is distinguished from asymmetry of a blood flow component in the acquired frequency spectrum.. .
Konica Minolta, Inc.

Ultrasonic diagnostic device, image processing device, and image processing method

An ultrasonic diagnostic device includes an ultrasonic probe and processing circuitry. The probe conducts ultrasonic scanning on a three-dimensional area of a subject and receives a reflected wave from the subject.
Canon Medical Systems Corporation

Appliance

An appliance includes a belt that is worn by being wound around a wrist. The appliance includes: at least a first display region that is positioned in an area of the belt that corresponds to a volar-side surface or a radius-side surface of the wrist; and a second display region that is positioned in an area of the belt that corresponds to a back-side surface of the wrist.
Omron Healthcare Co., Ltd.

Container device for collecting, storing and processing blood or a blood compound

Container device (1) for collecting, storing and processing blood or a blood compound, which comprises a tube (10) with a connector (23) on its distal end (13), a piston set (30, 50) that can move through an interior space (14) of the tube (10), and a valve set (70, 90) preventing the flow of fluid through the distal opening (16) of the tube (10). The valve set (70, 90) is operable to allow the flow of the fluid through the distal opening (16).
Biotechnology Institute, I Mas D, S.l.

Method for spectrophotometric blood oxygenation monitoring

An apparatus and method for non-invasively determining a blood oxygen parameter value of a subject's tissue is provided. An embodiment of the method includes the steps of: a) providing a spectrophotometric sensor that includes a processing portion and a transducer, b) detecting at least a portion of transmitted light after passage through the subject's tissue and producing initial signal data from the detected light; and c) using the processing portion to: (i) determine a value representative of an attenuation of at least one wavelength of light detected; (ii) determine whether the representative attenuation value is outside a predefined range of attenuation values; and (iii) determine the blood oxygen parameter value using a first interrogation or an alternate interrogation setting..
Cas Medical Systems, Inc.

Device and determining analyte levels

Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device.
Dexcom, Inc.

Imaging system for diagnosing patient condition

A system and method of characterizing a blood vessel. An imaging modality is utilized to take an image of the blood vessel that is under a first stimulated condition and an image of the blood vessel is under a second stimulated condition.
General Electric Company

System and physiological parameter monitoring

The present disclosure relates to a device, method and system (100) for calculating, estimating, or monitoring the physiological parameters of a subject. At least one processor, when executing instructions, may perform one or more of the following operations: receiving a first signal representing a pulse wave relating to heart activity of a subject, receiving a plurality of second signals representing time-varying information on the pulse wave, determining a blood oxygen level of the subject based on the plurality of second signals, identifying a first feature in the first signal, identifying a second feature in one of the plurality of second signals, computing a pulse transit time based on a difference between the first feature and the second feature, calculating a blood pressure of the subject based on the pulse transit time..
Vita-course Technologies Co., Ltd.

Novel optical interferometric scanning detector for cardiovascular function monitoring

The object of the present invention is to disclose a novel optical miniaturized handheld medical device for convenient monitoring and/or data collection of detailed signals on human cardiovascular function. The implementation consists of a number of advanced technologies, including interferometric detection, phase controlled focusing beam steering, auto-tracking scheme and algorism, and integrated optical chip assembly to enhance the device's performance and miniaturization.
Omnisensing Photonics, Llc

Blood pressure measuring apparatus and physical feature information calculating method

A blood pressure measuring apparatus includes: a triaxial acceleration sensor; an information output section which outputs information for guiding an arm of the person on which the blood pressure measuring apparatus is worn, to a pair of a first posture and a second posture between which a position of the wrist is different; a posture determiner which determines that the arm has been in each of the pair of the postures, based on an output signal of the triaxial acceleration sensor after the output of the information; and a physical feature information calculator which calculates physical feature information of the person based on moving acceleration information detected by the triaxial acceleration sensor in a period between when the arm is in one of the pair of the postures and when the arm is in the other of the pair of the postures.. .
Omron Healthcare Co., Ltd.

Biological information measurement apparatus and biological information measurement method

A biological information measurement apparatus includes: a pressure sensor including a pressure detecting element; a pressing mechanism which presses the pressure sensor against an artery in a living body; a press controller which controls a pressing force of the pressing mechanism; a blood flow sensor; a blood flow information measurer which measures blood flow information based on output of the blood flow sensor; a pressing force decider which decides a first pressing force based on blood flow information measured during a pressing force control time period when the pressing force is changed in one direction, and information of a pressure pulse wave detected during the pressing force control time period; and a record controller which records a pressure pulse wave detected in a first state where the pressing force is controlled to the first pressing force, and blood flow information measured in the first state.. .
Osaka University

Detection of peripheral arterial disease

A system for screening for peripheral artery disease (pad), including a plurality of instruments for measuring presence of blood flow derived physiological parameters, a data collection unit attached to each one of the instruments for receiving signals from each one of the instruments, and a data analysis unit for determining a likelihood of presence of pad based, at least in part, on the received signals. Related apparatus and methods are also described..
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.

Information processing device, information processing method, and program

The present technology relates to an information processing device, an information processing method, and a program for enabling continuous measurement of information in a body. The information processing device includes: a light emitting unit that emits light of a predetermined wavelength; an imaging unit that captures reflected light from an object; an analysis unit that analyzes an image captured by the imaging unit; a storage unit that stores an analysis result analyzed by the analysis unit; a communication unit that transmits the analysis result stored in the storage unit to another device; and a battery unit that generates and stores power to supply electric power to each unit, and the information processing device is embedded in a body to operate.
Sony Semiconductor Solutions Corporation

Blood pressure and cardiac monitoring system and method thereof

A blood pressure and cardiac monitoring system includes a sensing assembly, processor, memory, communication interface, and any suitable computer implemented modules communicatively coupled to each other via a bus. The sensing assembly comprises a first, second, and third sensor.
Robert Bosch Gmbh

Blood treatment machine having electrical heartbeat analysis

A blood treatment machine includes a blood pump; an arterial line in fluid communication with the blood pump; a venous line; and a heartbeat evaluation system including (i) a first electrode coupled to the arterial line or to a patient, (ii) a second electrode coupled to the venous line, (iii) electronic circuitry communicating electrically with the first electrode and the second electrode to sense an electrical heartbeat signal generated by the patient, and (iv) signal processing configured to use the sensed heartbeat signal to calculate at least one of (a) heart rate, (b) respiration, (c) stroke volume, (d) cardiac output, or (e) central blood volume.. .
Suntory Flowers Limited

National University Corporation Yamagata Universit Y

. .

Multi-junctional bleeding simulator

The present invention, when used by a live actor, allows users to safely simulate hemorrhaging in some of the most challenging blood vessels in the most challenging anatomical locations such as the carotid artery, the axillary artery, and the inguinal artery. The present invention further provides the ability for users to safely perform hemorrhage control procedures, such as compression and ligation.

Method and analyzing blood

A blood analyzing method for detecting a short sample of blood in a suction tube, when blood is sucked by the suction tube constituting a blood analyzing apparatus, includes measuring a first blood parameter by using blood that is present in a first area of a blood analysis area, blood in the blood analysis area being used to analyze the blood in the suction tube, measuring a second blood parameter by using blood that is present in a second area of the blood analysis area, the second area being different from the first area, and detecting the short sample of blood based on the first blood parameter and the second blood parameter.. .
Nihon Kohden Corporation

Diagnostic test for alzheimer's disease based on identification of a proteolytic pathway

A method for detecting circulating levels of beta amyloid peptides in an individual by administration of one or more inhibitors of an extracellular proteolytic pathway in blood and detection of the beta amyloid peptides in the blood or a fraction thereof. An example of an inhibitor is an anticoagulant.
Health Research, Inc.

Diagnostic blood test for sarcoidosis

Sarcoidosis is a multisystem disease characterized by granulomatous inflammation in affected organs. The present invention discloses kits and a system for a blood test using mycobacterial catalase-peroxidase that has a high positive predictive value for confirming a diagnosis of sarcoidosis..

Cancer diagnostic

Disclosed is the use of latrophilin expression as a biomarker for the diagnosis of haematopoietic cell cancer in a subject, together with methods for diagnosis and a kit for the detection of latrophilin expression on white blood cells collected from a subject.. .
University Of Kent, School Of Pharmacy

Immunoassay test slide

An immunoassay test slide for use in a dry chemistry analytical instrument includes a slide housing or case formed from two matable sections—a slide cover piece and a slide bottom piece. The slide housing defines an interior cavity in which is situated a sheet-like porous carrier matrix.
Idexx Laboratories, Inc.

Sample analyzer and computer program product

A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed..
Sysmex Corporation

Test sensor with multiple sampling routes

An improved disposable electrochemical test sensor designed to facilitate sampling of fluid samples. It has a fluid chamber having a novel extra wide sampling entrance.
Changsha Sinocare Inc.

Systems and methods for multiplexed hemostasis test panels

The invention features a diagnostic platform utilizing t2 magnetic resonance to directly measure integrated reactions in whole blood samples such as clotting, fibrinogen, clot contraction, and fibrinolysis to provide a comprehensive assessment of hemostatic parameters on a single instrument in minutes. The methods of the invention can be performed with less than 1 ml of blood and minimal sample handling..
T2 Biosystems, Inc.

Compound optical flow cells and manufacture and use

An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells) in liquid suspensions. Preferably manufactured by assembling, aligning, and optically joining at least two elements made from transparent material, the improved flow cell has a seamless internal flow channel of preferably non-circular cross-section in a cylindrical first element through which prepared samples can be metered and an independent second element having an external envelope suited to acquisition of optical parameters from formed bodies in such suspensions, the second element being conforming and alignable to the first element so that non-axisymmetric refractive effects on optical characterizing parameters of formed bodies passing through the flow channel in the first element may be minimized before the two elements are optically joined and fixed in working spatial relationship.
Beckman Coulter, Inc.

Method to distinguish and analyze white blood cells in the presence of red blood cells

Method for distinguishing between red blood cells and white blood cells. The method includes obliquely illuminating the blood sample with light from at least two rotational angles and analyzing light side scattered from cells in the sample to provide accurate discrimination of white blood cell types based on the anisotropy of red blood cell side scatter as compared to more isotropic white blood cell side scatter..
Massachusetts Institute Of Technology

Red blood cell dynamics for administering treatment for iron-deficiency anemia

Methods for identifying patients with anemia, distinguishing thalassemia-trait anemia from iron-deficiency anemia, and identifying pre-anemic patients several weeks before anemia becomes clinically detectable. Also, methods for detecting blood doping in athletes and for optimizing therapy with erythropoiesis stimulating agents or iron supplementation.
The General Hospital Corporation

Methods for obtaining regulatory t cells and uses thereof

Disclosed is a method for obtaining a population of human treg cells including the steps of: (a) culturing a population of human monocytes with a medium including an amount of an interleukin-34 (il-34) polypeptide in order to obtain a population of immunosuppressive macrophages; (b) co-culturing a population of human peripheral blood mononuclear cells (pbmcs) and the population of immunosuppressive macrophages obtained at step (a).. .
Centre Hospitalier Universitaire De Nantes

Sanitation systems and components thereof having a slippery surface

The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces. Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as liquid b to repel a wide range of materials, referred to herein as object a (solid a or liquid a).
President And Fellows Of Harvard College

Method for suppressing blood coagulation reaction for which lox-1 is responsible

The present invention provides an anti-blood coagulant capable of selectively suppressing a pathological blood coagulation reaction without increasing the risk of major bleeding. The anti-blood coagulant in accordance with the present invention includes a binding inhibiting component that inhibits the binding of lox-1 to at least one of factor v and factor va..
National Cerebral And Cardiovascular Center

Compositions and methods for treatment of diseases

A method for treating or preventing laminitis is provided comprising administering to an ungulate a therapeutically or prophylactically effective amount of a camelid protease inhibitor. Typically the ungulate is a horse and the camelid protease inhibitor is an inhibitor of equine metalloproteinases and equine serine proteases.

Methods and compositions for increasing red blood cells

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.. .
Acceleron Pharma Inc.

Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators

Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.
Glaxosmithkline Llc

Leukocyte and microparticles fractionation using microfluidics

This invention relates to a method for separating blood cells comprising the steps of: (a) lysing red blood cells of a blood sample and diluting said sample; (b) providing a microfluidic device comprising a spiral-shaped flow channel having at least a first end and a second end, wherein said flow channel has two inlet ports at or near said first end and at least two outlet ports at or near said second end, wherein one of the two inlet ports is located at the inner wall of the spiral-shaped flow channel and the other inlet port is located at the outer wall of the spiral-shaped flow channel and at least one of the outlet ports is connected to a container allowing the storage of blood cells; (c) introducing the sample of step (a) into the inlet port located at the outer wall of the spiral-shaped flow channel and introducing a sheath fluid into the inlet port located at the inner wall of the spiral-shaped flow channel; (d) driving said sample and the sheath fluid through the spiral-shaped flow channel; and (e) recovering the blood cell in the at least one container connected to the at least one outlet port. The present invention also relates to coupling above described method of purifying neutrophils in the native state with a method for diagnosing diabetes or an inflammatory disease in a subject, which involves further investigation of neutrophils by determining their rolling speed, the neutrophil circularity (nc) index and/or the expression of markers, such as intracellular reactive oxygen species (ros), cd1 1 b or psgl-1..
Nanyang Technological University

In vitro epithelial models comprising lamina propria-derived cells

An in vitro microfluidic “organ-on-chip” is described herein that mimics the structure and at least one function of specific areas of the epithelial system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and the associated tissue specific epithelial cells and endothelial cells.
Emulate, Inc.

Microfluidic device for real-time clinical monitoring and quantitative assessment of whole blood coagulation

A microfluidic coagulation assessment device includes a plurality of microchannels, with a blood sample driven through the microchannels at a substantially constant flow rate. A controller is configured to, in combination with a timer and a pressure sensing device, determine a first pressure value (or flow value) at an initiation of flow, a first time (tpg) at which a second pressure value is about twice the determined first pressure value, and a second time (tpf) at which a third pressure value is about (1+e) times the determined first pressure value and establish a subject coagulation model predictive of channel occlusion therefrom..
President And Fellows Of Harvard College

Separation membrane for blood processing and blood processing device including the membrane

Wherein r1 is a hydrogen atom or a methyl group; r2 is a methyl group or an ethyl group; n is 2 to 6 and m is 1 to 3; p denotes the number of repetition; and a plurality of each of r1, r2, n, and m present in one molecule may be the same or different.. .

Centrifuge and system for bodily fluid sample

The invention relates generally to health tests and needs to examine bodily fluids such as blood. The invention comprises a centrifuge and system for a bodily fluid sample.
Medigoo Oy

Using emotional maps and dialog display technology to improve workout experiences

Systems, apparatuses and methods may provide for technology to improve a workout experience of a user by determining an emotional state of the user, identifying a workout route based on the emotional state of the user, and outputting the workout route via a user interface device. Additionally, determining the emotional state of the user may include inferring emotions from one or more sensor information or user speech information.
Intel Corporation

Patient-specific functional cranioplasty with integrated ultrasonic transmitter arrangement for neuromodulation and opening of the blood brain barrier

The invention relates to an ultrasonic transmitter arrangement (1) with a plurality of ultrasonic transmitters (2) arranged on the arrangement whose emittable ultrasonic waves are focused toward a common focus (3). The arrangement (1) is embodied as a cranial bone implant (4) that can be implanted in the cranial bones (5) of a person as a replacement for one or more parts of the cranial bone (5), with the common focus (3) of the entire arrangement being arranged in a defined region of the brain (6) in the implanted state..

Methods and systems for controlling blood pressure by controlling atrial pressure

Systems and methods for controlling blood pressure by controlling atrial pressure and atrial stretch are disclosed. In some embodiments, a stimulation circuit may be configured to deliver a stimulation pulse to at least one cardiac chamber of a heart of a patient, and at least one controller may be configured to execute delivery of one or more stimulation patterns of stimulation pulses to the at least one cardiac chamber, wherein at least one of the stimulation pulses stimulates the heart such that an atrial pressure resulting from atrial contraction of an atrium overlaps in time a passive pressure build-up of the atrium, such that an atrial pressure of the atrium resulting from the stimulation is a combination of the atrial pressure resulting from atrial contraction and the passive pressure build-up and is higher than an atrial pressure of the atrium would be without the stimulation, and such that the blood pressure of the patient is reduced..
Backbeat Medical, Inc.

Cardiac health monitoring systems and methods involving hypertension relief device(s) and/or features

Systems and methods involving hypertension monitoring and/or treatment device(s) are disclosed. According to implementations herein, various combination systems, devices and methods that provide therapy and/or monitoring capabilities of a person's blood pressure, incorporating a ppg/ecg integrated sensor within the handle of a hypothermia therapy device for persons with hypertension, are provided..
Physiocue, Inc.

Method and device for enhanced blood flow

A non-invasive method and device for promoting a localized change in a flow of blood through a blood vessel in a limb segment of a body by a series of electrically stimulated contractions of muscle tissue in the limb segment, the method including the steps of: (a) providing a device including: (i) first, second and third electrodes, each adapted to operatively contact the limb segment; (ii) a signal generator, operatively connected to the electrodes, adapted to produce a series of electrical impulses to the limb segment via the electrodes, and (iii) a control unit adapted to control the signal generator to produce the series of electrical impulses; (b) positioning the electrodes on the limb segment, wherein the first electrode is positioned on a lower end of the lower leg, the second electrode is positioned on the lower leg, and the third electrode is positioned on an upper end of the lower leg, whereby the first and third electrodes are disposed on opposite ends of the lower leg, and the second electrode and one of the first and third electrodes are disposed on a same end of the lower leg; (c) effecting a sequence of muscular contractions of the lower leg, by operations including: (i) applying a first electrical impulse between the electrodes on the same end of the lower leg to induce a first muscular contraction of a first portion of the tissue; and (ii) applying at least a second electrical impulse between the first and third electrodes to induce a longitudinal muscular contraction of a second portion of the muscular tissue; and (d) repeating operations (i) and (ii), to repeatedly induce the contractions, to effect the increased flow of blood.. .

Systems and methods for treatment of fluid overload

Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system.
White Swell Medical Ltd

Valved catheters including high flow rate catheters

A pressure activated two-way slit valve assembly is designed to be used in combination with, but not limited to, a high flow rate catheter to prevent accidental ingestion of air or loss of blood if the closure cap comes off during non-use of the catheter. In addition, the potential for occlusion of the esthete due to blood clots in the catheter and catheter related infection is substantially reduced.
Angiodynamics, Inc.

Oxygen biofeedback device and methods

Supplemental oxygen is used by millions of people each year in hospitals and at home. The device and methods described allow people on supplemental oxygen through a feedback loop to optimize their blood oxygen level by measuring oxygen and/or carbon dioxide and/or other related gases in the blood.

Extracorporeal ambulatory assist lung

An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment for pressurizing blood entering the pressurizing stator compartment from the blood flow inlet.
Mississippi State University

Human-shaped graphical element for medical treatment user interfaces

Graphical user interfaces for use with extracorporeal blood treatment systems may include a human-shaped graphical element and one or more process feature graphical elements. The human-shaped graphical element may be moved automatically or manually by users with respect to the process feature graphical elements to provide indications with respect to the process features corresponding to the human-shaped graphical element and the process feature graphical elements..
Gambro Lundia Ab

Apparatus for the non-invasive measurement of the blood flow

The present invention comprises an apparatus for the non-invasive measurement of the blood flow through a shunt of a patient, wherein the apparatus has at least one bandage which can be worn by the patient as well as a plurality of sensors which are arranged in or at the bandage, which are arranged in at least one multidimensional matrix and which are configured such that they create a multidimensional matrix of measured values of at least one parameter detected by the sensors.. .
Fresenius Medical Care Deutschland Gmbh

Filter element for blood processing filter, blood processing filter, and blood processing method

The present invention provides a filter element for a blood processing filter, comprising a nonwoven fabric, wherein the rebound strength per unit basis weight (g/m2) before steam heat treatment is 0.3 (n·m2/g) or larger.. .
Asahi Kasei Medical Co., Ltd.

Alert on a dialysis machine

A dialysis machine comprising: a first sensor for detecting motion of a patient; a second sensor for detecting a health condition of the patient; a processing module for: controlling dialysis functions of a dialysis treatment; receiving information related to a status of the dialysis treatment in which toxins are removed from blood of the patient; receiving, from the first sensor, information related to the motion of the patient; receiving, from the second sensor, information related to the health condition of the patient; and identifying an emergency condition based at least in part on the information related to the motion of the patient, the information related to the health condition of the patient, and the information related to the status of the dialysis treatment; and a transceiver for: in response to identifying an emergency condition, sending a notification that includes patient information to one or more remote entities.. .
Fresenius Medical Care Holdings, Inc.

Blood collection canister assembly

A blood collection canister assembly enables a user to collect and transfer blood and includes liner and lid assemblies. The liner assembly is formed from a flexible liner material and defines an inner liner space.
Ecomed Solutions Llc

Expansible cardiovascular stent with collagen covering membrane

Disclosed is an expansible cardiovascular stent with a collagen covering membrane, comprising a reticular and tubular stent (1) and a covering membrane attached to the reticular and tubular stent. The reticular and tubular stent (1) and the covering membrane both have a certain extensibility.
Dongguan Dianfu Product Design Co., Ltd.

Carrier for use in delivering drug, conjugate, composition comprising same, and administrating same

The present invention provides a vesicle, a conjugate, a composition comprising the vesicle or the conjugate, for use in delivering a drug to the brain, and a method for administering the same. The composition of the present invention is a composition for administration to a subject according to a dosing regimen, comprising a carrier for drug delivery, wherein the dosing regimen comprises administering the composition to a subject who has been fasted or caused to have hypoglycemia and inducing an increase in blood glucose level in the subject, and the carrier is modified at the outer surface thereof with a glut1 ligand..
National University Corporation Tokyo Medical And Dental University

Therapeutic compositions of alpha-l-iduronidase, iduronate-2-sulfatase, and alpha-galactosidase a and methods of use thereof

The present invention provides pharmaceutical compositions comprising an a blood brain barrier peptide and a human peptide, such as an alpha-l-iduronidase (idua) protein, an iduronate-2-sulfatase protein (ids) protein, or an a galactosidase a protein (α-gal a) protein. The invention further provides methods of use for treating mucopolysaccharidosis type i (mps i), including hurler syndrome, hurler-scheie syndrome and scheie syndrome; methods of use for treating hunter syndrome; and methods of use for treating fabry disease..
Alexion Pharmaceuticals, Inc.

Drug regimen for treatment of cerebral ischemia

Treatment of subjects experiencing cerebral ischemia is improved when the treatment employs a thrombolytic and an inhibitor against vascular endothelial growth factor receptor signal transduction (vegf-rst) at a reduced, low dosage compared to that used to treat cancer patients. The treatment is also improved to permit point-of-care use by formulating protein drugs for long term stability at room temperature, providing doses appropriate for the method, and by combining the therapeutic agents with a point-of-care diagnostic for blood brain barrier integrity..
Shimojani, Llc

Allogenic tumor cell vaccine

The described invention provides a tumor cell vaccine comprising genetically modified tumor cell line of a particular tumor type that stably expresses high levels of two or more immunomodulators. According to some embodiments, an immunogenic amount of the tumor cell line variants may be selected for concomitant expression of two or more of recombinant membrane expressed igg1, cd40l, tnf-alpha, as well as membrane and soluble forms of gm-csf, and flt-3l peptides that are effective to elicit an anti-tumor immune response compared to the parent unmodified tumor cell line as measured in vitro by a one-way mixed lymphocyte tumor reaction assay using human peripheral blood mononuclear cells and the genetically modified allogeneic cell vaccine candidate.
Alloplex Biotherapeutics

Modulation of factor xa inhibitor-mediated blood loss by partial and transient administration of antidote

The present disclosure provides unit dose formulations and methods to reduce, stop or prevent bleeding in a patient undergoing anticoagulant therapy with a factor xa inhibitor. The methods entail at least partial neutralization of the factor xa inhibitors the unit dose formulations and methods of the present disclosure can be effective even after actual bleeding has initiated..
Portola Pharmaceuticals, Inc.

Herbal topical composition for muscle and joint health, recovery from exertion, and for pain management

A topical liniment composition that boost muscle relaxation, increase blood flow, and increase cutaneous delivery of herbal extract that contains polyphenols derived from red chili, black pepper, cinnamon, and turmeric includes a quantity of castor-mineral oil-camphor solution, a quantity of eucalyptus oil, a quantity of clove oil, a quantity of peppermint oil, a quantity of frankincense oil, a quantity of herbal extract concentrate solution, and a quantity of castor oil. Aforementioned ingredients are heterogeneously mixed with each other to formulate the topical liniment composition at standard temperature and pressure (stp).

Use of fk506 for the treatment of pulmonary arterial hypertension

A method for reducing pulmonary hypertension in a mammal that employs fk506 is provided. In certain embodiments, the method comprises administering fk506 to a mammal having pulmonary arterial hypertension associated with defective mbpr2 signaling at a dosage sufficient to reduce blood pressure in the pulmonary artery of the mammal..
The Board Of Trustees Of The Leland Stanford Junior University

Therapeutic agent for dyslipidemia

The present invention addresses the problem of providing a pharmaceutical combination composition and drug combinations for the prevention and/or treatment of dyslipidemic conditions such as atherosclerosis, hypercholesterolemia, low hdl blood disease in mammals including humans. A pharmaceutical composition for the prevention and/or treatment of dyslipidemia, etc.
Kowa Company, Ltd.

Methods of treating hypertriglyceridemia

In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.. .
Amarin Pharmaceuticals Ireland Limited

Tripulse release stimulant formulations

A single dosage form that delivers a tripulse (i.e., three pulses) release profile is provided. The dosage form includes at least three dosage units inside the final dosage form.
Cingulate Therapeutics Llc

Rejuvenation of billions of eyelids and eyes

A system and method for preventing and reducing droopy and puffy eyelids and for preserving and restoring visual acuities and preventing and reducing presbyopia and visual losses. The system comprises an apparatus having diverse structures for modulating and controlling the circulations and volumes of blood and fluids in eyelids, eyes and surrounding soft tissues and a means for avoiding the compression and disruptions of the circulations and physiology of the corneas and lenses, networked repositories for predicting and extrapolating trends of developments of said conditions and the needs of utilizations of said system and networked machines for producing individual customized apparatuses for fitting said organs and tissues of individuals..

Expandable device for capturing regurgitant jet, volume, and force to effect ventricular function and remodeling

An implant system for capturing a regurgitant jet to effect preserving the atrioventricular pressure gradient and ventricular remodeling in a human heart including an expandable implant for positioning in the atrial/ventricular valve of the human heart and at least partially within the atrium and/or the ventricle, the expandable implant defining a first position for at least partially capturing the atrioventricular pressure gradient and regurgitant trans-valvular blood flow and associated driving forces during systole and a second position for steering flow from the atrium to the ventricle to enhance vorticular flow during diastole; a therapeutic apical base plate attachable to the apex of the heart; and a tethering conduit connected between the expandable implant and the therapeutic apical base plate assembly that transducts the energy and/or forces of captured regurgitant trans-valvular blood flow or atrioventricular pressure to the structures of the ventricle and the ventricular wall.. .
Harmony Development Group, Inc.

Orthopaedic or biologic support structure, methods of making and methods of use

A support 70 for use with tissue or bone is described, the support 70 having one or more spaced apart brace members 72, and at least one elongated linking member 80 for linking to the one or more spaced apart brace members 72. The support 70 may be provided in use in combination with a biologic glue, the biologic glue comprising a first portion containing stabilized blood product, and a second portion containing a growth factor, the first portion and the second portion comingled when or after the support is introduced to the tissue or bone in a subject in need thereof.
Buck Medical Research Ltd.

Catheter apparatuses for modulation of nerves in communication with pulmonary system and associated systems and methods

Devices and systems for the selective positioning of an intravascular neuromodulation device are disclosed herein. Such systems can include, for example, an elongated shaft and a therapeutic assembly carried by a distal portion of the elongated shaft.
Medtronic Ardian Luxembourg S.a.r.l.

Energy treatment instrument, treatment system, and controller

An energy treatment instrument includes a first grasping piece, and a second grasping piece which opens or closes relative to the first grasping piece and which grasps a blood vessel between the first grasping piece and the second grasping piece. In accordance with the kind of blood vessel grasped between the first grasping piece and the second grasping piece, an actuation state of the energy treatment instrument is switched between a first mode to coagulate a blood vessel of a circulatory system, and a second mode to coagulate a blood vessel of a pulmonary circulation in contrast to the first mode..
Olympus Corporation

Coaptive surgical sealing tool

A coaptive surgical sealing tool may be similar to an ordinary hemostat with long (50, 60, 70 or 80 mm) thin jaws for sliding into the liver parenchyma, without tearing the larger blood vessels. The jaws are spring loaded and are designed for uniform compression, and to avoid closing too quickly.
City Of Hope

Ablation applicator with a matrix filled with particles

An ablation applicator for an ablation device for ablating tissue of a blood vessel having a tubular body defining an inner lumen to which an ablation medium is conductable, a control mechanism for converting the tubular body between a passive operation mode for inserting the ablation applicator into the blood vessel and an active operation mode for ablating tissue of the blood vessel, and an ablation medium supply line for supplying the ablation medium to the inner lumen and positioned within the inner lumen and having a number of openings for passing the ablation medium from the ablation medium supply line to the inner lumen for thermally contacting the ablation medium with the tubular body wherein at least some of the openings are distributed along the ablation medium supply line with a predetermined spacing between neighboring openings. The ablation device can include a first temperature sensor arranged within the inner lumen and an ablation medium return line inside the tubular body made from a material that defines the active shape of the applicator..
Afreeze Gmbh

Flexible intra-vascular aneurysm treatment stent

An intra-vascular aneurysm-treatment stent and a method for lowering pressure within an aneurysm bubble in a blood vessel. A stent coil is insertable into a blood vessel, the coil made of a material sufficiently flexible to move around curves, loops, and corners in the blood vessel.

Systems and methods for acute treatment to limit intracerebral hemorrhage growth

A method for the hemostasis of perforating and bleeding vessel related to intracerebral hemorrhage (ich) includes navigating an occlusion device into a parent artery and then deploying the occlusive device to transiently occlude bleeding vessels to reduce blood flow and local blood pressure until hemostasis is achieved, while maintaining flow within the parent artery. Embodiments of the occlusion device include a catheter, an expandable member sized for insertion into the mid-cerebral artery (mca) and having a length sufficient to occlude at least one ostia of the lenticulostriate arteries (lsa), with a flow path for blood provided from a proximal side of the expandable member to a distal side of the expandable member, and a semi-permeable contacting member about the expandable member and adapted to be in contact with a wall of the mca adjacent the ostia, the semi-permeable member permitting a reduce flow of blood through the ostia..
Cerepeutics, Llc

Anti-migration surgical ligation clip

The present disclosure provides a surgical clip for ligating a blood vessel or tissue structure. The surgical clip includes a first leg member including a first inner surface and a first plurality of protrusions disposed on the first inner surfaces.
Nanova Biomaterials, Inc.

Device for connecting hollow organs, especially blood vessels, by surgery

A sleeve for enforcing the end of a hollow organ so that it can be connected with a further end of a hollow organ, the sleeve comprising a cylindrical shape and being configured to be pushed over the end of the hollow organ and for turning-over the end of the hollow organ projecting from the sleeve around an end of the sleeve, wherein the sleeve has an adjustable diameter.. .
King Faisal Specialist Hospital & Research Centre

Apparatus and k-edge based interior tomography image processing

Provided are an apparatus and method for k-edge based interior tomography image processing. The apparatus efficiently performs tomography image reconstruction by acquiring different material images using an energy-selective detector, such as a photon counting detector.
Rensselaer Polytechnic Institute

Method and device for diagnosis of breast disease

The present invention relates to a method and a device for diagnosis of breast disease and, more specifically, to an x-ray mammography device and method, which allow positions of an x-ray radiation field and a thermogram acquisition means to be controlled such that the center axis of the x-ray radiation field and a visual axis of the thermogram acquisition means are the same, so as to acquire each of a mammogram and a breast thermogram having the same center, and generates a fusion image so as to obtain a structural image and an image of a physiological change (body temperature and the activity of blood vessels) of breast tissue, thereby improving an early diagnosis and diagnosis ability for breast disease.. .
Industrial Education Cooperation Organization Deagu Health College

Systems and methods including a human-shaped graphical element

Graphical user interfaces for use with extracorporeal blood treatment systems may include a human-shaped graphical element and one or more process feature graphical elements. The human-shaped graphical element may be moved automatically or manually by users with respect to the process feature graphical elements to provide indications with respect to the process features corresponding to the human-shaped graphical element and the process feature graphical elements..
Gambro Lundia Ab

System for collecting blood samples from a patient, and corresponding sample collection device and pumps for extracting blood from a patient

A system for taking blood samples from a patient, including a peristaltic pump having a rotor with a moving surface and a fixed surface for lodging therebetween a flexible tube and a head member for attachment of a sample holder tube support member, and a blood sampling device including a needle holder having a tubular portion for supporting a hypodermic needle having a connection base, the needle holder including a conduit with an inlet and an outlet, where the inlet has the tubular portion, the sample holder tube support member, and the flexible tube having a first end in fluid communication with the needle holder and a second end in fluid communication with the support member.. .
Cliniclab S.l.

Portable clinical analysis system for hematocrit measurement

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof..
Abbott Point Of Care Inc.

Calibration of glucose monitoring sensor and/or insulin delivery system

Disclosed are methods, apparatuses, etc. For calibrating glucose monitoring sensors and/or insulin delivery systems.
Medtronic Minimed, Inc.

Non-invasive intracranial pressure monitoring system and method

A system which includes a first sensor placed proximate to a perfusion field of an artery receiving blood which emanates from the cranial cavity is configured to monitor pulsations of the artery receiving blood which emanates from the cranial cavity artery. A second sensor placed proximate to a perfusion field of an artery which does not receive blood emanating from the cranial cavity configured to monitor pulsations of the artery which does not receive blood emanating from the cranial cavity.
Vivonics, Inc.

Blood pressure monitor cuff, manufacturing the same, and blood pressure monitor

A blood pressure monitor cuff is formed by stacking an outer circumferential layer arranged on a side opposite to that of a measurement site and a fluid bladder arranged on the measurement site side. The outer circumferential layer and the fluid bladder are formed of an elastomer material.
Omron Healthcare Co., Ltd.

Automated fitted cuff blood pressure and arm circumference measuring device

A blood pressure device having a cylindrical drum cuff housing adapted to measure the circumference of either a right or left arm and administer a blood pressure test. The drum cuff housing is connected to a knuckle support assembly adapted to provide freedom of movement for postural positioning before and during the blood pressure test..
Higi Sh Llc

Blood pressure measurement system using force resistive sensor array

A novel and useful pressure sensor array incorporating sensor elements constructed from electrically conductive film as a substrate. Examples of commercially available electrically conductive (i.e.
Livemetric (medical) S.a.

Viscoelasticity characteristics acquisition device, viscoelasticity characteristics acquisition method, viscoelasticity characteristics acquisition program, and recording medium recording said program

A viscoelastic characteristics acquisition device is a device that acquires viscoelastic characteristics of a blood vessel of an inspection target, and includes a pulse wave acquisition unit that acquires a time waveform corresponding to a volume pulse wave of the inspection target, a spectrum acquisition unit that acquires a volume pulse wave spectrum by performing fourier transform on the time waveform, an input unit to which values corresponding to maximum blood pressure and minimum blood pressure of the inspection target are input, and an analysis unit that acquires the viscoelastic characteristics on the basis of the values corresponding to the maximum blood pressure and the minimum blood pressure and the volume pulse wave spectrum at a frequency equal to or higher than a frequency corresponding to the pulse of the inspection target.. .
Hamamatsu Photonics K.k.

Reliable estimation of pulse transit time in motion for cuffless blood pressure estimation

Apparatuses, systems, and methods described herein can enable reliable estimation of pulse transit time (ptt) for a user in motion for cuffless blood pressure estimation. In one embodiment, a method involves receiving an electrocardiographic (ecg) signal and a photoplethysmographic (ppg) signal and detecting r-wave peaks in the ecg signal.
Intel Corporation

System and providing user feeedback of blood pressure sensor placement and contact quality

A novel and useful system and method for generating user feedback related to the quality of the placement and contact of a blood pressure sensor on a user's body. The sensor is incorporated in a wearable blood pressure measurement device that is capable of analyzing and providing feedback regarding the quality of placement and contact of the pressure sensor array.
Livemetric (medical) S.a.

Blood pressure ratio calculation device, blood pressure ratio calculation method, blood pressure ratio calculation program, and recording medium recording said program

A blood pressure ratio calculation device is a device for calculating a maximum-minimum blood pressure ratio corresponding to a ratio between a maximum blood pressure value and a minimum blood pressure value of an inspection target, and includes an input unit for inputting a relative blood pressure waveform corresponding to temporal change in relative blood pressure of the inspection target, a spectrum generation unit for generating a relative blood pressure waveform spectrum by performing fourier transform on the relative blood pressure waveform, and an analysis unit for calculating the maximum-minimum blood pressure ratio on the basis of the relative blood pressure waveform spectrum.. .
Hamamatsu Photonics K.k.

Auxiliary device for blood pressure measurement and blood pressure measuring equipment

The present invention discloses an auxiliary device for blood pressure measurement, including an audio collection part, an image collection part, and a terminal device. The present invention further provides blood pressure measuring equipment.

Alarm system that processes both motion and vital signs using specific heuristic rules and thresholds

The invention provides a body-worn monitor that measures a patient's vital signs (e.g. Blood pressure, spo2, heart rate, respiratory rate, and temperature) while simultaneously characterizing their activity state (e.g.
Sotera Wireless, Inc.

Compositions and methods for attracting insects

Disclosed are compositions for attracting insects (e.g., harmful or troublesome insects such as blood-sucking and biting insects, ticks and mites) to an object (e.g., insect trap) or area (e.g., field, orchard). Also disclosed are methods for attracting insects involving treating (or exposing) the object or area with a composition containing compounds described herein (e.g., a pro-fragrance compound selected from the group consisting of an acetal, a ketal, hemiacetal and mixtures thereof, wherein at least one of a parent aldehyde, ketone, or alcohol of the pro-fragrance acetal or ketal is a fragrance compound), and optionally a carrier or carrier material..
The United States Of America, As Represented By The Secretary Of Agriculture

Injectable preserving medium for preserving cells from placental blood, from bone marrow and from peripheral blood

The present invention relates to a solution for the preservation of cells from placental blood, from bone marrow and from peripheral blood. .
Centre National De La Rescherche Scientifique

Systems and methods for the treatment of aneurysms

Systems and method for treating aneurysms are provided which utilize formulations that form polymer foams in situ. The formulations generally have a buoyancy greater than or less than blood, and either float to the top of the aneurysm and foam from the top down or sink to the bottom and foam from the bottom up..
Sunglory Beheer B.v.

Low molecular weight polyethylene glycol drug conjugates having improved drug biological activity

Provided are polyethylene glycol drug conjugates of general formula (i), (ii) or (iii) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules.
Sunglory Beheer B.v.

Intravascular devices and delivery systems and uses thereof

In general, the invention features an intravascular device, a delivery system, and methods for filtering or deflecting emboli or other large objects from entering a protected secondary vessel or vessels the intravascular device of the invention may prevent passage of a particle in a blood vessel from passing through a filter supported by a frame, upper and lower stabilizers, and a wire. The wire may be used to stabilize the device upon its deployment and installation within a blood vessel.
Sunglory Beheer B.v.

Interactive intravascular procedure training and associated devices, systems, and methods

Devices, systems, and methods of intravascular procedure training are provided. In some instances, the method includes outputting, from a computing device to a display device in communication with the computing device, a first visual representation of a blood vessel; determining, using the computing device, a first course of action based on the first visual representation of the blood vessel; receiving, at an input device in communication with the computing device, a user input associated with a second course of action; comparing, using the computing device, the first and second courses of action; and outputting, from the computing device to the display, a comparison of the first and second courses of action.
Koninklijke Philips N.v.

Method and determining biometric indicators using multiple fluorescent markers

Disclosed are methods for determining biometric indicators such as plasma volume, hematocrit and glomerular filtration rate, in mammalian subjects such as humans. The methods utilize a plurality of fluorescent tags having distinct fluorescent characteristics, which may be associated with a single static molecule, or wherein the static molecule is labeled with a fluorescent tag and a dynamic molecule is labeled with another fluorescent tag.
Pharmacophotonics, Inc. D/b/a Fast Biomedical

Intergrin alpha v beta 6 for diagnosis/prognosis of colorectal carcinoma

The invention relates to a method for diagnosis of colorectal carcinoma in a patient, including detecting, in a blood sample obtained from said patient, an indicator protein selected from integrin subunit alpha(v) and integrin subunit beta(6) or their heterodimer.. .
Universitat Zurich

Monocyte integrin based microfluidic assay for evaluating coronary diseases

A diagnostic system for assessing cardiovascular health is provided that incorporates a microfluidic platform and sensors that capture inflammatory monocytes. The portable microfluidic platform shears activated monocytes in a small volume of blood (˜50 μl) over a glass substrate that mimics the stress and molecular constituents of an inflamed artery.
The Regents Of The University Of California

Measuring frequency of pathogen-specific t cells in peripheral blood

A method for detecting and quantifying of the frequency of t cells to multiple antigenic peptide epitopes comprising: measuring intracellular ca2+ signaling in individual t cells that are labeled with ca2+ sensitive fluorophore; wherein said t cells are placed on the glass bottom of a well-covered with antibodies or other capturing proteins specific for non-stimulatory t cells' surface receptors and wherein a peptide antigens are injected into the well and the peptide binds to mhc molecules on the t-cell surface, wherein an increase in the intracellular concentration of ca2+ in responding t cells leads to rise in intracellular fluorescence that is detected by fluorescent microscope and wherein the response rate of said detected fluorescence can be utilized to determine the quantity of responding t cells and the efficiency of said cells.. .
Thomas Jefferson University

Point of care sepsis assay device and method

Disclosed is a point of care sepsis assay comprising a disposable assay cartridge with a sample inlet for a blood sample, a filter to isolate blood plasma, a source of multivalent cations to cause a turbidity change in the plasma sample and a transparent window to measure the change in turbidity and the use of said assay in the diagnosis of sepsis.. .
Sepsis Limited

Allogeneic autophagosome-enriched composition for the treatment of disease

A method is presented for screening cells that produce allogeneic autophagosome enriched compositions able to induce expression of a selective marker on a subpopulation of peripheral blood mononuclear cells, the method comprising contacting a cell with a proteasome inhibitor, contacting the cell with a lysosome inhibitor, harvesting the resulting autophagosomes, determining a molecular signature of the harvested autophagosomes, and selecting cells that divert one or more toll-like receptor agonist and/or one or more molecular chaperones to the harvested autophagosomes. By screening for cells that divert one or more toll-like receptor agonist and/or one or more molecular chaperones to the harvested autophagosomes, enriched populations of autophagosomes may be generated which may illicit a specific immune response against numerous cancer types.
Providence Health & Sevices-oregon

Method for diagnosing fibromyalgia using micrornas

Method of diagnosing fibromyalgia based on micrornas. The invention provides a method for the molecular diagnosis of fibromyalgia patients, based on the analysis of the possible alteration of the levels of specific micrornas in peripheral blood mononuclear cells.
Universidad CatÓlica De Valencia "san Vicente MÁrtir"

High-purity galactooligosaccharide compositions, preparations, and applications thereof

Provided is a method of preparing a high-purity galactooligosaccharide composition by fermentation of a low-purity galactooligosaccharide mixture with a yeast strain, kluyveromyces lactis atcc 8585. The high-purity galactooligosaccharide composition includes at least 99% of galactooligosaccharides selected from the group consisting of galactotriose, galactotetrose, galactooligosaccharides with five or more sugar units, and combinations thereof and lower than 1% of monosaccharides and disaccharides.
King-prebiotics Biotechnology (tw) Co., Ltd.

High-purity galactooligosaccharide compositions, preparations, and applications thereof

Provided is a method of preparing a high-purity galactooligosaccharide composition by fermentation of a low-purity galactooligosaccharide mixture with a yeast strain, kluyveromyces lactis atcc 8585. The high-purity galactooligosaccharide composition includes at least 99% of galactooligosaccharides selected from the group consisting of galactotriose, galactotetrose, galactooligosaccharides with five or more sugar units, and combinations thereof and lower than 1% of monosaccharides and disaccharides.
King-prebiotics Biotechnology (tw) Co., Ltd.

Magnetic nanostructure for detecting and isolating cell-free dna comprising cationic polymer and magnetic-nanoparticle-containing conductive polymer

Provided is a magnetic nanostructure for detecting and isolating cell-free dna (cfdna) that including a cationic polymer and a magnetic-nanoparticle-containing conductive polymer. The magnetic nanostructure for detecting and isolating cfdna according to the subject matter can significantly improve detection and extraction efficiencies of dna present in a urine, csf, blood plasma, or blood sample, and exhibits an enhanced sensitivity.
National Cancer Center

Cell composition depleted from tcrab and cd45ra positive cells

The invention is directed to a method for the preparation of a cell population from a sample originating from bone marrow or blood, comprising the steps a) dividing the sample into a first fraction containing 50 to 99% of the cells of the sample and a second fraction containing 50 to 1% of the cells of the sample, b) labeling the cells of the first fraction with a first marker against tcr alpha/beta, c) labeling the cells of the second fraction with a second marker against cd45ra, d) removing the labeled cells from the first and second fraction and combining the remaining cells to a cell population. Furthermore, the invention is directed to a cell composition and the use of the cell composition.
Miltenyi Biotec Gmbh

Fusion protein containing bdnf

Disclosed is a fusion protein containing a brain-derived neurotrophic factor (bdnf). The fusion protein is a fusion protein of bdnf and a specific range of human anti-transferrin receptor antibody, which makes bdnf administered into the blood able to pass through the blood-brain barrier..
Jcr Pharmaceuticals Co., Ltd.

Compounds suitable for treatment of haemophilia

The present invention relates to vwf compounds as well as compositions suitable for treatment of blood clotting diseases.. .
Novo Nordisk A/s

Method and device for detecting cellular targets in bodily sources using carbon nanotube thin film

A device and method detect cellular targets in a bodily source by utilizing a biofunctional pad comprised of a thin film of carbon nanotubes (cnt's). When antibodies are absorbed by the cnt's, cellular targets having markers matching the antibodies may be detected in a bodily source placed upon the biofunctional pad by measuring the conductivity of the thin film using conductive contacts electrically coupled to the thin film, as the binding of the receptors in the cellular targets to the antibodies changes the free energy in the thin film.
University Of Louisville Research Foundation, Inc.

Method for separating blood plasma and metering thereof

A capillary driven microfluidic device with blood plasma separation means that can be used to separate, meter and transfer a blood sample. The blood separation means can be arranged as a capillary pump by the configuration of a porous membrane and the microfluidic device..
Capitainer Ab

Blood vessel optical fiber guide wire

A blood vessel optical fiber guide wire includes at least one of optical fiber core wire, a wire wrapping layer and a hydrophilic coating capable of improving compatibility with body liquids and reducing the resistance. The optical fiber core wire is disposed in a core of the optical fiber guide wire.

Internal thoracic vein placement of a transmitter electrode for leadless stimulation of the heart

Implantable medical device systems and methods of use including an implantable first medical device having a lead with a transducer thereon and an implantable second medical device having a receiver for receiving energy emitted by the transducer. The lead may be placed in an internal thoracic vein, and other locations may be used as well.
Cardiac Pacemakers, Inc.

Method and the dialysis of blood

Apparatus for use in dialyzing a patient comprising a hemodialysis catheter comprising an elongated body having a proximal and a distal end, wherein the distal end terminates in a substantially planar distal end surface; first and second lumens extending from the proximal end to the distal end, wherein the lumens terminate on the distal end surface in first and second mouths, arranged in side-by-side configuration, and further wherein the lumens are separated by a septum; and first and second longitudinal slots formed in the distal end of the elongated body and communicating with the interiors of the lumens, the slots opening on the distal end surface; wherein the slots each have a length and a width, relative to the dimensions of the lumens and the rate of blood flow to be passed through the hemodialysis catheter, so as to minimize undesirable recirculation of dialyzed blood.. .
Medical Components, Inc.

Chamber for blood treatment system and method using same

A chamber is provided for a blood treatment system and has at least one space defined by a chamber wall, at least one blood inlet, and at least one inlet for a further fluid, which are connected with the space. Both the at least one blood inlet and the at least one inlet for the further fluid are formed on tube sections that protrude into the space of the chamber.
Fresenius Medical Care Deutschland Gmbh

Catheter pump with positioning brace

A catheter pump assembly is provided that includes an elongate body assembly, a shaft, and an impeller. The assembly has a proximal end, a distal end and at least one lumen extending therebetween.
Tc1 Llc

Composition for treating hyperlipidemia comprising oxyntomodulin derivative

The present invention relates to a composition for preventing or treating hyperlipidemia, fatty liver disease or arteriosclerosis, comprising an oxyntomodulin derivative as an active ingredient. The oxyntomodulin derivative has a high ability to activate glp-1 receptor and glucagon receptor compared to native oxyntomodulin and has the effects of reducing the blood total cholesterol, low-density cholesterol and triglyceride levels that were increased by high-fat diet, and increasing high-density cholesterol levels and the high-density cholesterol/low-density cholesterol ratio.
Hanmi Pharm, Co., Ltd

Therapeutic uses of elsiglutide

The invention relates to therapeutic uses of elsiglutide, particularly for protecting and stimulating bone marrow and peripheral blood cell type activity or immune-response in patients compromised due to the administration of chemotherapeutic agents. The invention further provides uses of elsiglutide to enhance the antitumor activity of cytotoxic chemotherapeutic agents and target specific biological agents..
Helsinn Healthcare Sa

Methods for prevention and treatment of acute renal injury

The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or exposure to a nephrotoxic agent, such as a radiocontrast dye.
Cornell University

Production and use of red blood cells

The present disclosure relates to the production of red blood cells from hematopoietic stem cells, by differentiating such cells in the presence of a protein that induces cell survival and proliferation.. .
Taiga Biotechnologies, Inc.

Inverted leaflet prosthetic valve

Prosthetic valve embodiments are described herein that include a frame and a valve member mounted within the frame. The valve members can have a plurality of leaflets that are affixed to one another along their inflow edges, with articulating edges projecting from the inflow edges in the outflow direction.
Edwards Lifesciences Corporation

Intravascular blood filter

Disclosed is a novel filter and delivery means. The device described within will not interfere with standard practice and tools used during standard surgical procedures and tools such as cannulas, clamps or dissection instruments including valve replacement sizing gages or other surgical procedures where the patient must be put on a heart-lung machine cross-clamping the aorta..
Claret Medical, Inc.

Aorticorenal ganglion detection

Devices and methods that regulate the innervation of the kidney by detection and modification of the aorticorenal ganglion. Devices for percutaneous detection and treatment of the aorticorenal ganglion via a blood vessel to modify renal sympathetic activity..

Energy treatment instrument, treatment system, and controller

An energy treatment instrument includes a first grasping piece, and a second grasping piece which opens or closes relative to the first grasping piece and which grasps a blood vessel between the first grasping piece and the second grasping piece. An actuation state of the energy treatment instrument is switched between a first mode to coagulate the blood vessel when a branch of the blood vessel is not present within a predetermined range from a position where the blood vessel is grasped, and a second mode to coagulate the blood vessel when the branch of the blood vessel is present within the predetermined range..
Olympus Corporation

Vascular graft securement apparatuses and related kits and methods

Some of the present apparatuses include a flexible vascular graft defining a lumen and a hub having a distal end con figured to penetrate a blood vessel, a proximal end, and a wall extending between the distal end and the proximal end that defines an interior passageway. In some apparatuses, the vascular graft is non-removably coupled to the hub, and the lumen of the vascular graft is in communication with the interior passageway of the hub.
Scott & White Healthcare

Devices and methods for reshaping blood vessels

Veins and other blood vessels may be reshaped by introducing an implant through the vessel walls with anchors positioned on opposite sides of the wall. The anchors typically include an elongate body having coils or other anchors formed therein.
Sano V Pte Ltd

Creating a vascular tree model

A method for vascular modeling is disclosed. The method, in some embodiments, comprises receiving a plurality of 2-d angiographic images of a portion of a vasculature of a subject, and processing the images to automatically detect 2-d features, for example, paths along vascular extents, which are projected into 3-d to determine homologous features among blood vessels.
Cathworks Ltd.

Blood vessel detection apparatus, magnetic resonance imaging apparatus and program

An mri apparatus comprises a image producing unit 101 for producing an image of a first body part containing a blood vessel; a defining unit 108 for defining a slice intersecting the image based on a reference position q within the first body part, the slice being defined so that an angle of the slice is changeable with respect to the blood vessel ve; a unit for obtaining an index vi for deciding whether or not the blood vessel ve is contained within the slice for each angle θ; and a determining unit 111 for determining an angle of the slice at which the blood vessel ve is contained in the slice based on the index vi.. .
General Electric Company

Blood sample optimization system and blood contaminant sequestration device and method

Blood sample optimization systems and methods are described that reduce or eliminate contaminates in collected blood samples, which in turn reduces or eliminates false positive readings in blood cultures or other testing of collected blood samples. A blood sample optimization system can include a blood sequestration device located between a patient needle and a sample needle.
Kurin, Inc.

Processing apparatus and processing method

A processing apparatus having a processor acquiring image data indicating oxygen saturation distribution inside an object by using signals derived from acoustic waves generated from a plurality of wavelengths of light. The processor acquires an oxygen saturation at a first position of a blood vessel of the object, generated by image reconstruction using signals, acquires a first correction amount to correct the oxygen saturation at the first position of the blood vessel, and acquires a second correction amount to correct the oxygen saturation in a second position of the object other than the first position, based on the first correction amount..
Canon Kabushiki Kaisha

Method and device for presenting st event in electrocardiogram

A method for presenting an st event in an electrocardiogram (ecg) comprises: drawing an amplitude trend graph of an st segment in the ecg; detecting an st event in the amplitude trend graph of the st segment; and marking the detected st event in the amplitude trend graph of the st segment. In the present invention, the st event is automatically detected and marked in the amplitude trend graph of the st segment, so that the st events are presented more intuitively, and the user can intuitively and quickly locate the st event in the amplitude trend graph of the st segment and quickly know a raised or depressed situation of the st event; the time of subsequent analysis and summary can be effectively reduced, and a blood supply state of the heart of the subject can be timely and quickly known..
Edan Instruments, Inc.

Fluid bladder, blood pressure measurement cuff, blood pressure monitor, and blood pressure measurement method

A fluid bladder has a first fluid bladder region that inflates due to receiving a supply of fluid and is contained in a portion of an outer circumferential surface of a measurement site in a lengthwise direction of a cuff, the portion corresponding to a first half surface, where an artery is. Also, the fluid bladder has an expansion region that is expanded due to an action from outside, and is contained at a portion of the outer circumferential surface of the measurement site that corresponds to a second half surface, in the lengthwise direction of the cuff.
Omron Healthcare Co., Ltd.

Touch-type blood pressure measurement apparatus and method

A touch-type blood pressure measurement apparatus is provided. The touch-type blood pressure measurement apparatus include: a touch sensor configured to generate a contact area signal when a finger of a user is in contact with the touch sensor; at least one photoplethysmogram (ppg) sensor configured to generate a ppg signal of the user while the finger is in contact with the touch sensor; a force sensor configured to generate a touch force signal of the finger in contact with the touch sensor; and a controller configured to obtain a blood pressure of the user based on the contact area signal, the ppg signal, and the touch force signal..
Samsung Electronics Co., Ltd.

Medical measuring device

A measuring device for the non-invasive measurement of physiological parameters is suited to detect and localize by way of self diagnosis diseases such as, for example, inflammations, tumors or arteriosclerosis. The measuring device includes at least one optical measuring unit, an evaluation unit processing the measuring signals, and a unit for the acquisition of local tissue parameters such as fat content, water content and/or blood perfusion.

Blood pressure measurement instrument, and korotkoff's sound recognition

A blood pressure measurement instrument includes: a cuff capable of being worn at a measured position on a body of a user, a pressure sensor, a sound sensor, a pressure regulator, and a processor. The pressure regulator is configured to regulate a pressure applied to the measured position by the cuff; the pressure sensor is configured to acquire the pressure applied to the measured position by the cuff during a period of time when the pressure is changed; the sound sensor is positioned between the cuff and the measured position in a measuring process and is configured to acquire blood flow sound at the measured position; and the processor is connected with the pressure sensor and the sound sensor and is configured to determine a blood pressure value of the user according to acquisition results of the pressure sensor and the sound sensor..
Boe Technology Group Co., Ltd.

Method to measure non-invasive blood pressure from patient sensor system

A system and method for enhancing the determination of the blood pressure of a patient is disclosed. The system includes a wireless blood pressure sensing device that obtains blood pressure data from the patient and wirelessly transmits the data to a host system.
General Electric Company

Method for producing blood chimeric animal

The present invention discloses a novel means capable of producing a blood chimeric animal in which a state of retaining blood cells originating in a heterologous animal, such as a human, at a high percentage is sustained for a long period of time, even in cases where a medium to large domestic animal is used as a recipient. The method for producing a non-human animal that retains blood cells originating in a heterologous animal, according to the present invention, comprises transplanting hematopoietic cells of a heterologous animal into a non-human animal, in which hematopoietic cells the function of a gene that acts on the hematopoietic system is modified.
The University Of Tokyo

Calla lily plant named 'bloody mary'

‘bloody mary’ is a new variety of calla lily plant having inflorescences with a red-colored spathe that produces 2-10 inflorescences per tuber. The height of the top of an inflorescence above the soil can reach up to 48 cm.
Sunglory Beheer B.v.

. .

Eye motion detection method, program, program storage medium, and eye motion detection device

Provided is a method to easily detect eye motions in the eye moving direction, which has resistance to a fluctuation in background light and to a displacement of the position of a camera. The method includes the steps of: detecting a white area of the eye from the eye area; determining a blood vessel image to be used for a template blood vessel image in the white area of the eye; detecting a nth blood vessel image, which matches the template blood vessel image; calculating a nth moving amount of the eye based on a difference between the reference position and the detection position of the nth blood vessel image, which matches the template blood vessel image; and calculating a nth rotation angle of the eye to detect eye motions in the information processing apparatus..

Blood vessel analysis apparatus, medical image diagnosis apparatus, and blood vessel analysis method

According to one embodiment, a structuring circuitry temporarily structures a dynamical model of analysis processing based on the time-series medical image. The identification circuitry identifies a latent variable of the dynamical model so that at least one of a prediction value of a blood vessel morphology and a prediction value of a bloodstream based on the temporarily structured dynamical model is in conformity with at least one of an observation value of the blood vessel morphology and an observation value of the bloodstream measured in advance.
Toshiba Medical Systems Corporation

Method and process for providing a subject-specific computational model used for treatment of cardiovascular diseases

A subject-specific simulation model of at least one component in the cardiovascular system for simulating blood flow and/or structural features. This simulation model can be used as a tool for cardiovascular diagnostic and/or treatment planning.
Sintef Tto As

Image processing apparatus and image processing method

An image processing apparatus determines an exceptional frame of a plurality of frames forming a moving image captured by an ophthalmic apparatus including an aberration correction device, and applies image processing of a blood vessel area for a frame, among the plurality of frames, which has not been determined as the exceptional frame.. .
Canon Kabushiki Kaisha

Rapid and sensitive forensic toxicology in post-mortem subjects using oral fluid testing

The present invention provides a rapid, sensitive method for forensic drug testing in a post-mortem subject using oral fluid collected from the post-mortem subject. The method comprises collecting a sample of oral fluid from a post-mortem subject, analyzing the oral fluid sample qualitatively to detect the presence of one or more non-naturally occurring drugs, analyzing the oral fluid sample quantitatively to determine concentration of the one or more non-naturally occurring drugs in the post-mortem subject, and identifying the one or more non-naturally occurring drugs in the post-mortem subject.

Bin1 expression as a marker of cancer

Provided are methods for screening a subject for cancer. The methods involve obtaining a blood sample from the subject and determining a level of bridging integrator 1 (bin1) isoforms comprising exon 12a in the sample.
Sarcotein Diagnostics, Llc

Systems and methods for assessing blood platelet function

A method carried out by a system configured to analyze blood. The method includes causing a ferromagnetic object to move in a chamber housing blood after clot initiation has been implicated.
Medtronic, Inc.

Composition for high stringency cell treatment and antigen retrieval

The present invention relates to a cell treatment composition for the permeabilization of fixed blood cells, to the use of said composition, to a method for the treatment of a biological sample comprising fixation of said sample and subsequently contacting said biological sample with said cell treatment composition. The invention further relates and to a kit comprising said cell treatment composition..
Beckman Coulter, Inc.

Allogeneic autophagosome-enriched composition for the treatment of disease

A method is presented for screening cells that produce allogeneic autophagosome enriched compositions able to induce expression of a selective marker on a subpopulation of peripheral blood mononuclear cells, the method comprising contacting a cell with a proteasome inhibitor, contacting the cell with a lysosome inhibitor, harvesting the resulting autophagosomes, determining a molecular signature of the harvested autophagosomes, and selecting cells that divert one or more toll-like receptor agonist and/or one or more molecular chaperones to the harvested autophagosomes. By screening for cells that divert one or more toll-like receptor agonist and/or one or more molecular chaperones to the harvested autophagosomes, enriched populations of autophagosomes may be generated which may illicit a specific immune response against numerous cancer types.
Providence Health & Sevices-oregon

Method and system for estimating whether a female is pregnant based on a blood sample

A method for estimating whether a female is pregnant, said method comprising measuring allele presences (d) for a plurality of genetic markers of at least one chromosome, different from the x and y chromosome, in a sample of cell-free dna from a potentially pregnant female; each allele presence representing the presence at a genetic marker of at least one of: a reference allele of maternal or foetal origin, and an alternative allele of maternal or foetal origin; based on said measured allele presences, determining a homozygous fraction (fho) thereof which is associated with purely homozygous genetic markers; and estimating whether the female is pregnant based on said fraction.. .
Multiplicom Nv

Dendritic cell generator

Devices, systems, and methods can be used for the automated production of dendritic cells (dc) from dendritic cell progenitors, such as monocytes obtained from peripheral blood. The invention makes it possible to obtain sufficient quantities of a subject's own dc for use in preparing and characterizing vaccines, for activating and characterizing the activation state of the subject's immune response, and to aid in preventing and/or treating cancer or infectious disease..
Northeastern University

Diblock copolymers and polynucleotide complexes thereof for delivery into cells

Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic ph, and a second block that has hydrophobic groups.
Phaserx, Inc.

Anti-human transferrin receptor antibody permeating blood-brain barrier

Disclosed are a means to convert compounds having physiological or pharmacological activity and unable to pass through the blood-brain barrier into a form that allows them to pass through the blood-brain barrier, and compounds converted thereby. The means is an anti-human transferrin receptor antibody and the converted compounds are molecular conjugates between physiologically active protein or pharmacologically active low-molecular-weight compounds and an anti-human transferrin receptor antibody..
Jcr Pharmaceuticals Co., Ltd.

Pharmaceutical composition for the prevention and treatment of cardiovascular disease comprising the peptide having the ability to inhibit angiotensin-1 converting enzyme as an active ingredient

The present invention relates to a peptide separated from the fraction of oyster enzyme hydrate displaying the ability of suppressing angiotensin converting enzyme (ace) and a pharmaceutical composition for the prevention and treatment of cardiovascular disease comprising the said peptide as an active ingredient. Particularly, the peptide separated from the fraction of the oyster enzyme hydrate of the present invention significantly inhibits ace activity, and thus brings blood pressure regulating effect and antihypertensive effect.
Industry-academic Cooperation Foundation Gyeongsang National University

Maleate salts of a quinazoline derivative useful as an antiangiogenic agent

The present invention relates to azd2171 maleate salt, to particular crystalline forms of azd2171 maleate salt, to processes for their preparation, to pharmaceutical compositions containing them as active ingredient, to their use in the manufacture of medicaments for use in the production of antiangiogenic and/or vascular permeability reducing effects in warm-blooded animals such as humans, and to their use in methods for the treatment of disease states associated with angiogenesis and/or increased vascular permeability.. .
Astrazeneca Ab

Device for pelvic limb blood flow

A structure including left and right footplates and weight shafts provided at left and right sides in a blood circulation exercise interlocking device, providing a pelvic limb blood circulation ankle interlocking device comprising a vertical supporter configured at the center of a lower plate of a main body in a vertical direction, left and right auxiliary vertical supporters configured to be parallel in a vertical direction at left and right sides of the vertical supporter, rotary shafts configured at the same position as the left and right auxiliary vertical supporters in a horizontal direction of the vertical supporter, left and right rotary bars configured at left and right sides of the rotary shaft to be coupled with a rotating device, weights made of heavy metals at the upper ends of the left and right rotary bars, and left and right footplates configured at left and right rotation lower ends.. .

Method for controlling a device for extracorporeal blood gas exchange, device for extracorporeal blood gas exchange, as well as control device for controlling a device for extracorporeal blood gas exchange

A method controls a device for extracorporeal blood gas exchange. The device has a membrane as a gas-liquid barrier between a bloodstream and a gas stream.
Drägerwerk Ag & Co. Kgaa

Treatment of cancer by manipulating the immune system

The present invention relates to the treatment of cancers. Specifically, the invention pertains to a method for the extracorporeal treatment of one or more body fluids (e.g., blood or cerebrospinal fluid, csf) in two stages characterized by removing a body fluid (e.g., blood or csf) from a living body diseased with a type of cancer, passing the body fluid through a first stage of applying a treatment to at least one antigen in the body fluid.
Marv Enterprises, Llc

Renal therapy system with cassette-based blood and dialysate pumping

A renal therapy system with cassette-based blood and dialysate pumping is disclosed. An example system includes a blood pump actuator, a dialysis fluid pump actuator, a dialysis fluid heater, a dialyzer, and a disposable unit.
Baxter Healthcare S.a.

Apparatus for extracorporeal blood treatment

An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. Spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood through the filtration unit (2), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant..
Gambro Lundia Ab

Blood pump

Apparatus and methods are described, including a catheter (20) configured to be placed inside a blood vessel of a subject. A first impeller (28) is disposed on the catheter, and a second impeller (28) is disposed on the catheter, proximally to the first impeller.
Magenta Medical Ltd.

Systems and methods for recovering white blood cells from a leukoreduction filter

A method of recovering white blood cells from a leukoreduction filter, the method comprising providing a solution comprising a sugar, flowing a volume of the solution through a leukoreduction filter containing captured white blood cells, and collecting elute from the leukoreduction filter, wherein the elute comprises the solution and recovered white blood cells.. .
Fenwal, Inc.

Immunoadsorption

Upon administration of raav vectors the humoral immune response (neutralizing antibodies) is the first barrier that needs to be overcome. Surprisingly it was found that by using immunoadsorption for depletion of immunoglobulins from the blood (plasma), subjects can be highly efficiently treated with raav vectors, i.e.
Uniqure Ip B.v.

Beta-casein a2 and antioxidant capacity

Improving the antioxidant capacity in an animal by increasing the level of glutathione in the blood or tissue of the animal comprising providing a composition containing beta-casein to the animal for consumption, where the beta-casein comprises at least 75% by weight of one or more beta-caseins not capable of producing beta-casomorphin-7 on enzymatic digestion. Uses include as an oxidant, for treating or preventing the symptoms of cancer, inflammation, kwashiorkor (protein deficiency), seizure, autism, down's syndrome, chronic fatigue syndrome, alzheimer's disease, parkinson's disease, sickle cell anaemia, liver disease, cystic fibrosis, hiv, aids, infection, heart attack, stroke, and diabetes, avoiding or reducing the effects of aging, promoting the recovery of tissue following physical exercise, and promoting fertility..
The A2 Milk Company Limited

Composition and methods for treatment of loss of fluids leading to hypotension and/or hypovolemia

The present invention is directed to a composition containing at least one salt, at least one natural or synthetic saccharide, and at least one natural or synthetic high molecular weight, non-ionic, hydrophilic polymer. When in a liquid form, the composition is ready for infusion or injection to patients that suffer from loss of fluids that causes reduced volume and/or pressure in the systemic circulation.
Cellphire, Inc.

Pet food compositions

Described herein are pet food compositions comprising a blood glucose management component comprising soy isoflavone and yeast beta-glucan (β-glucan); along with methods of making and using same.. .
Hill's Pet Nutrition, Inc.

Compositions and methods that modulate white blood cells or neutrophils in a companion animal

White blood cells and/or neutrophils in a companion animal can be improved by adjusting the diet of the animal to increase the amount of a compound which positively or negatively modulates the white blood cells and/or neutrophils or adjusting the diet of the animal to decrease the amount of a compound which positively or negatively modulates the white blood cells and/or neutrophils.. .
Nestec Sa

Treatment of restenosis using temsirolimus

Described herein are methods for distributing temsirolimus to a tissue surrounding a blood vessel for treating vascular diseases. Also disclosed are injectable compositions of temsirolimus for delivery into the tissue surrounding a blood vessel for treating vascular diseases..
Mercator Medsystems, Inc.

Chitosan nanofibres containing bioactive compounds

The invention relates to self-assembled nanofibers of chitosan and bioactive compounds for use as nutraceuticals or drugs. Suitable bioactive compounds include molecules of a low molecular size with acid or lactone groups, aromatic rings and hydroxyls.
Universidad De Valparaiso

Long acting liraglutide compositions

The present invention relates to a long acting composition comprising, therapeutically effective amount of liraglutide, a block or a graft copolymer comprising hydrophilic and hydrophobic moieties or mixtures thereof, at least one amphipath, and an aqueous vehicle, wherein the composition is in the form of a gel which is rendered injectable when forced through a needle by means of a plunger. The composition provides effective blood glucose control for about 6 days to about 14 days after single administration to a subject in need thereof, in particularly for about a week..
Sun Pharma Advanced Research Company Limited

Sublingual therapeutic solutions and methods

Supplement formulations of estrogen blocker, glycogen manager, and muscle recovery solutions and sublingual therapies for increasing absorption rates thereof. The sublingual delivery systems allow the body to absorb up to 94.9% of each dose directly into the bloodstream, completely bypassing the digestion process.

Methods for delivering entanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the gi tract. Many embodiments provide a swallowable device for delivering the agents.
Rani Therapeutics, Llc

Blood bag and blood bag label with such a label

The present invention relates to an adhesive label intended to be secured to a blood bag made of pvc, kraton, polypropylene or the like, wherein the adhesive label comprises a flexible support and a layer of pressure-sensitive adhesive deposited on one of the surfaces of the support; wherein the label is noteworthy in that the support has a mineral filler rate of silica and/or calcium carbonate (caco3) and/or the like, of less than 50%, and wherein at 115° c., the support has an elongation greater than or equal to 2% when a test piece 1.5 cm wide of the support is suspended under tension by a weight of 375 g for 75 minutes, and wherein the blood bag at 115° c. Has an elongation of at least 100% when a 1.5 cm wide test piece of a blood bag is suspended under tension by a weight of 375 g for 75 minutes..
Adhex Technologies

Method of air reduction in stent graft delivery device

Methods of reducing air within a stent graft delivery device are disclosed, utilizing various flushing techniques. A port in a manifold that includes a pusher catheter coaxially disposed about a guide wire catheter is flushed.
Cook Medical Technologies Llc

Stent apparatus and treatment methods

There is disclosed a method of treating hypoxia in tissue of a blood vessel, the method comprising placing a stent in the vessel, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall. There is disclosed a method of treating a subject with diabetic atherosclerosis, the method comprising placing a stent in a blood vessel of the subject, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall..
Veryan Medical Limited

Catheter-based apparatuses and methods

Blood flow into vascular tissue is filtered in a manner that can also be useful for trapping particulates while allowing the flow of blood. Consistent with one or more embodiments, a filter apparatus includes a filter, an outer delivery sheath such as a catheter, and one or more shafts that are operable to manipulate the shape of the filter for positioning within vascular tissue.
Transverse Medical, Inc.

Catheter-based apparatuses and methods

Blood flow into vascular tissue is filtered in a manner that can also be useful for trapping particulates while allowing the flow of blood. Consistent with one or more embodiments, a filter apparatus includes a filter, an outer delivery sheath such as a catheter, and one or more shafts that are operable to manipulate the shape of the filter for positioning within vascular tissue.
Transverse Medical, Inc.

Method for treatment of varicocele

A minimally invasive method for treating varices in especially sensitive areas, including pelvic varices in females, varicoceles, and also oesophageal varices is presented. The method comprises the steps of making a micro incision into the blood vessels of a patient, endoscopically inserting a catheter device into the blood vessel of a patient and advancing the distal end of the catheter to reach the varix or varices.
Biolitec Unternehmensbeteiligungs Ii Ag

Non-occlusive circumferential vascular ablation device

A device for internal circumferential ablation of a tubular vascular structure includes an expandable structure having a central opening extending therethrough to allow a relatively unobstructed flow of body fluid through the tubular vascular structure. The expandable structure is expandable from a collapsed configuration to an expanded configuration, with the expandable structure being configured to be secured in a desired location on the tubular vascular structure.
Persistent Afib Solutions, Inc.

Apparatus and method to stop bleeding

A hemostatic device is provided to stop bleeding at a puncture site on the wrist of a patient, the device comprising a transparent flexible band to be wrapped at the site where the bleeding is to be stopped, a curved frame having an inner peripheral side and possessing a first curved portion in its first half and a second curved portion in its second half, a first balloon provided on the inner peripheral side in the first half of the curved frame and a second balloon provided on the inner peripheral side in the second half of the curved frame. The bleeding from a first artery is stopped by compressing the first artery at the puncture site using inflation of the first balloon and the blood flow in the first artery is increased by compression of a second artery using inflation of the second balloon..
Vasoinnovations, Inc.

Photoplethysmography apparatus

The invention relates to a photoplethysmography apparatus (100), comprising a source of light (110) configured to provide source light (130) of at least a first and a second spectral position directed at a tissue (140); alight detector (120) configured to detect scattered source light, and to provide at least a first and a second sensor signal (127, 29) indicative of the scattered source light of the first and second spectral position; and a processing unit (150). The processing unit is configured to calculate a corrected sensor signal (160), indicative of a variation in blood absorbance within the tissue, by removing a tissue-path error signal component, indicative of a variation in optical path length through the tissue over time, and a light-coupling error signal component, indicative of a variation of source light intensity of the source light emitted at the tissue, from the at least first and second sensor signals..
Koninklijke Philips N.v.

Regional oximetry sensor

A regional oximetry sensor has a sensor head attachable to a patient skin surface so as to transmit optical radiation into the skin and receive that optical radiation after attenuation by blood flow within the skin. The sensor includes windows that press into the skin to maximize optical transmission.
Masimo Corporation

System and monitoring and determining patient parameters from sensed venous waveform

Devices, systems, and methods for monitoring patient hemodynamic status, systemic vascular resistance, reversal of cardiac and respiratory rates, and patient respiratory volume or effort are disclosed. A peripheral venous pressure is measured and used to detect levels, changes, or problems relating to patient blood volume.
Baxter Healthcare Sa

Brain activity estimation device

A brain activity estimation device includes a brain activity estimation portion. The brain activity estimation portion includes a blood-circulation-amount calculating unit and an estimation unit.
Tokyo Institute Of Technology

Gel based livestock feed, manufacture and use

The gel feed may then be fed to the livestock. In another aspect of the present invention, piglets are weaned by feeding the gel feed for at least seven days directly after weaning.

Methods and compositions for cryopreservation of endothelial cells

Brain microvascular endothelial cells (bmecs) can be generated from pluripotent stem cells, and possess membrane barrier functions along with capability for maturation into other developing tissues. This cell type has not been successfully frozen with loss of significant viability and/or bmec functional properties.
Cedars-sinai Medical Center

System for washing red blood cells to reduce hemolysis

A system for washing red blood cells, comprising a separator configured to separate a quantity of blood into concentrated red blood cells having a hematocrit of at least 60% and a volume of 150-250 ml, and a supernatant component. The system comprises a flow controller configured to remove the supernatant component to provide an initial red blood cell concentrate; combine 50-500 ml of an additive solution with the red blood cell concentrate to provide an intermediate red blood cell product intended for storage for 42 days or less, wherein the intermediate red blood cell product at the end of storage has an osmolarity value between 202-479 mosm/l; and wash the intermediate red blood cell product comprising the osmolarity value between 202-479 mosm/l with a washing solution having an osmolarity value higher than that of the intermediate red blood cell product comprising the osmolarity value between 202-479 mosm/l..
Fenwal, Inc.

Test panel to measure blood neurotoxin levels in prematernal women and for the general public in relation to mental disorders of the aging

A prescribed diagnostic blood test panel is directed to countering autistic and mentally affected births and assessing the continued healthy mental state of the elderly. Six neurotoxins in the blood are analyzed, five of which can produce damage to the brain, namely aluminum, arsenic, lead, mercury and manganese.

Methods of diagnosing clostridium difficile infection or recurrence in a subject

Methods are described for identifying cdi patients as well as cdi patients at risk for recurrence. Embodiments include: (1) flow cytometry of circulating peripheral blood mononuclear cells (pbmc) to phenotype for the less efficient immunoglobulin response to bacterial toxins and surface antigens that characterizes patients who will become recurrent; (2) stratification by means of complete blood count (cbc) using a coulter counter to detect the differences in lower angle light scatter (lal), which has a larger range in the recurrent population; and (3) stratification by means of complete blood count (cbc) using a coulter counter to detect the lower axial light loss (al2) exhibited in recurrent patients..
University Of Cincinnati

Method and determining a probability of colorectal cancer in a subject

A method of determining a probability that a human test subject has colorectal cancer as opposed to not having colorectal cancer is disclosed. The method comprises, for each gene of a set of one or more genes selected from the group consisting of anxa3, clec4d, il2rb, lmnb1, prrg4, tnfaip6 and vnn1: determining a level of rna encoded by the gene in blood of the test subject, thereby generating test data; providing positive control data representing levels of rna encoded by the gene in blood of human control subjects having colorectal cancer, and providing negative control data representing levels of rna encoded by the gene in blood of human control subjects not having colorectal cancer; and determining a probability that the test data corresponds to the positive control data and not to the negative control data, where the probability that the test data corresponds to the positive control data and not to the negative control data represents the probability that the test subject has colorectal cancer as opposed to not having colorectal cancer..
Genenews, Inc.

Methods for the detection of genomic copy changes in dna samples

The present invention includes compositions and methods useful for the detection of a mutational change, snp, translocation, inversion, deletion, change in copy number, or other genetic variation within a sample of cellular genomic dna or cell-free dna (cfdna). In some embodiments, the compositions and methods of the present invention provide an extremely high level of resolution that is particularly useful in detecting copy number variations in a small fraction of the total cfdna from a biological sample (e.g., blood)..
Resolution Bioscience, Inc.

Preservation of cell-free nucleic acids

A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids..
Streck, Inc.

Recombinant adeno-associated vectors for targeted treatment

Novel adeno-associated virus (aav) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues.
City Of Hope

Copolymer and medical device, separation membrane module for medical use, and blood purifier including the same

A copolymer has blood compatibility and antithrombotic properties of greatly suppressing protein adhesion to be usable even when in contact with a biological component such as blood for a long period of time, and a medical device uses the copolymer. The copolymer is characterized by including a hydrophilic unit and a hydrophobic unit, wherein the hydrophobic unit contains at least one type of a carboxylic acid vinyl unit, and the number of carbon atoms at the terminal of a side chain of the carboxylic acid vinyl unit is 2-7..
Toray Industries, Inc.

Substituted aromatic compounds and pharmaceutical uses thereof

The present invention relates to substituted aromatic compounds of formula i and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, a nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders..
Prometic Pharma Smt Limited

Integrated patient monitor system

A point-of-care medical testing system integrated with a patient monitor is disclosed. The system may include a microfluidic cartridge configured to receive a blood sample and generate a sensory signal dependent on a concentration of a biomarker in the blood sample.
Pooyandegan Rah Saadat Co.

Occluding catheter and dynamic prevention of stroke

A system for use in prevention of stroke is provided that has a shaft that carries an occluding balloon. The occluding balloon is inflated to occlude blood flow through at least one of a right carotid artery and a left carotid artery.

Intravenous catheter stopper

A stopper is provided for preventing blockage of a cannula of an intravenous catheter in-between uses including a hub having a connector for securing to the catheter, and a stylet having a length and a shape configured to fill a lumen of the cannula, where the hub is configured to place the stylet within the lumen of the cannula, and where the stylet is configured to prevent blood from clotting within the lumen of the cannula when inserted in a patient between uses. In some implementations, the stopper can have a movable stylet.
King Abdullah International Medical Research Center

Infusion pump system and methods

Some embodiments an infusion pump system can be configured to activate an alarm in response to a calculated prediction of the user's future blood glucose levels. Optionally, the predictive calculation of the user's future blood glucose levels can be based at least in part upon a recent blood glucose level, a trend of blood glucose levels over time, and an insulin load of the user..
Bigfoot Biomedical, Inc.

Dialysis bloodline set and use

A dialysis bloodline set includes an arterial chamber with upper, lower and central portions, in which the central portion forms a vertical riser tube having a maximum section area less than that of the lower portion. The lower portion has a shoulder which is positioned to deflect blood entering the lower portion to flow across the aperture at the lower end of the riser tube.
Oxyless Limited

Pump, system with a blood pump and producing a blood pump

The invention relates to a blood pump made of titanium with a measuring device for determining flow based on acoustic flow measurement methods, and a blood pump with a temperature sensor and/or a pressure sensor, and a system with a blood pump and an inlet cannula and/or an outlet connector and a method for producing a blood pump with a measuring device.. .
Heartware, Inc.

Device for controlling a blood flow produced in a hemorrhagic area

A device for controlling blood flow occurring in a haemorrhagic zone of a biological tissue, includes a flexible plate arranged to be placed opposite this zone, the flexible plate including: substantially leaktight peripheral supporting elements, for applying on the tissue so that the zone is surrounded; a back wall delimiting, with the supporting elements, opposite the zone, a hollow space; connecting elements connecting the hollow space, externally to the flexible plate, to an external aspiration source for creating a vacuum in the hollow space for aspirating and tightly applying the surface of the tissue against the peripheral supporting elements; and a hollow stud placed between the zone and the back wall and hollowed out in its centre on the side of the zone along an axis substantially perpendicular to the back wall, and arranged to be in contact with the zone when the vacuum is created in the space.. .
Centre Hospitalier Universitaire De Grenoble

Compositions and methods for transport across the blood brain barrier

Compositions and methods are provided including a transporter peptide derived from the loop2 domain of the neuronally-derived lynx protein which can be conjugated to an effector agent to form a transporter-effector complex for transport of the therapeutic effector agent to a target that is found across the blood brain barrier.. .
Ophidion Inc.

Truncated von willebrand factor polypeptides for treating hemophilia

The invention relates to a polypeptide comprising a truncated von willebrand factor (vwf) for use in the treatment of a blood coagulation disorder, wherein the polypeptide carries a half-life extending moiety and is administered in molar excess over factor viii and/or endogenous vwf.. .
Csl Behring Recombinant Facility Ag

Antidiabetic oral insulin biguanide combination

Pharmaceutical dosage forms, comprising insulin, a delivery agent that facilitates insulin transport in a therapeutically effective amount to the bloodstream and a biguanide, such as metformin, are disclosed for oral administration to a patient for the treatment of diabetes. Also disclosed are methods for achieving improved glucose tolerance and glycemic control in a diabetic mammal without any statistically significant increase in weight, risk of hypoglycemia or hyperinsulinemia, and the need for monitoring blood glucose concentrations or hba1c levels, and methods for reducing the incidence and/or severity of one or more disease states associated with chronic dosing of insulin; for prophylactically sparing (3-cell function or for preventing (3-cell death or dysfunction in a mammal with impaired glucose tolerance or early stage diabetes mellitus; and for long-term protection from developing (or delaying the onset of) overt or insulin dependent diabetes in a mammal with impaired glucose tolerance or early stage diabetes..
Emisphere Technologies, Inc.

Methods of obtaining mononuclear blood cells and uses thereof

Methods of obtaining mononuclear blood cells are provided. Also provided are methods of using the obtained cells for treating diseases such as cancer, infectious disease, autoimmune disease, allergy, and graft rejection..
Biolinerx Ltd.

Use of a block polymer comprising a block of poly(3-(methacryloylamino)propyltrimethylammonium chloride) (pmaptac) for the neutralization of heparin

The subject of the invention is use of block polymers with a block of poly(3-methacryloylpropyltrimethylammonium chloride) to direct neutralization of heparin, especially unfractionated heparin and low molecular weight heparins in the blood and other body fluids.. .
Uniwersytet Medyczny W Bialymstoku

Combination sis and vacuum bandage and method

A wound care bandage for treating a wound is provided. The bandage includes an sis layer to be placed on the wound surface and a cover to be placed over the wound.
Kci Medical Resources Unlimited Company

Concurrent treatment of oral and systemic maladies using direct current electricity

A method and apparatus for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing electricity are provided for non-human animals. Electrodes are used to deliver an electrical current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits.
Biolectrics Llc

Method and system for image processing to determine blood flow

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data.
Heartflow Inc.

Evaluating prosthetic heart valve placement

A method for evaluating the placement of a prosthetic heart valve in a structure of interest. The method comprises acquiring one or more depictions of an anatomical region of interest that includes the structure of interest, wherein each depiction shows the structure of interest and/or the blood pool volume of the left ventricular outflow tract (lvot) of the patient's heart.
Henry Ford Health System

Total laparoscopic two-stage surgical resection of side of liver of patient via liver-surrounding band method

The present invention discloses a completely laparoscopic staged hepatectomy using round-the-liver ligation, which is carried out as follows: (1) a complete laparoscopic operation is performed with general anesthesia using round-the-liver ligation, the branches of the portal vein of the hemiliver to be removed are ligated, meanwhile a tourniquet is used to tighten the connecting part between the right and the left hemilivers to block the communicating blood flow between the hemiliver to be removed and the hemiliver to be reserved, a drainage tube is put into the peritoneal cavity at the hepatic hilus, then close the peritoneal cavity, and the operation is completed; (2) the patient gradually resumes eating after the first operation, and recuperate for 6-15 days to make the volume of the hemiliver to be reserved increase to the expected volume of the future liver remnant, in which the expected volume of the future liver remnant should be at least 30-40% of the standard liver volume; (3) after the volume of the hemiliver to be reserved has increased to the expected volume of the future liver remnant, a complete laparoscopic liver resection is carried out with general anesthesia to remove the diseased hemiliver, and then the patient is nursed to be completely recovered.. .

Implantable medical device and system to heat tissue

A medical implant device (18) for atrial appendage (20) is presented, suitable to transmit energy to its surrounding. The medical implant device (18) comprising an expandable structure (31,34) and a cover (32) disposed on the expandable structure is adapted to extend across the ostium (21) of the atrial appendage (20) for restricting migration of thrombi from the appendage to the blood stream in the heart (13).
Koninklijke Philips N.v.

Cannula with proximally mounted camera

A cannula system and method for accessing a blood mass in the brain. The system comprises a cannula with a camera mounted on the proximal end of the cannula with a view into the cannula lumen and the surgical field below the lumen.
Rebound Therapeutics Corporation

Device for detecting blood flow disturbance

A blood flow disorder detection device includes: a sensor sheet including a flexible substrate and a plurality of sensors provided on the flexible substrate; and an analyzer that analyzes outputs of the plurality of sensors. The plurality of sensors measure different types of blood flow information of a living tissue, the blood flow information being obtained by attaching the sensor sheet to the living tissue.

Method and system for dealing with breathing anomalies

A system for dealing with breathing anomalies can monitor a subject for indications of breathing anomalies while the subject is sleeping. For example, the system can monitor blood oxygen saturation utilizing a pulse oximeter placed on a finger or toe, breathing rate utilizing a camera, or another appropriate physiological parameter.
Sensory Innovation Solutions, Inc.

Blood collection device

The application relates to a blood collection device comprising: a cannula hub defining a chamber; an in-let cannula defining an axis and having a distal end and a lumen extending therethrough, the inlet cannula being mounted to the cannula hub such that the distal end of the inlet cannula is external of the cannula hub and such that the lumen through the inlet cannula communicates with the chamber; an outlet cannula having a proximal end and a lumen extending therethrough, the outlet cannula being mounted to the cannula hub such that the proximal end of the outlet cannula is external of the cannula hub and such that the lumen of the outlet cannula communicates with the chamber; a closed sleeve mounted over a portion of the outlet cannula disposed externally of the cannula hub; and a venting mechanism providing communication between the chamber and ambient surroundings.. .
Poly Medicure Limited

Blood lancet with hygienic tip protection

The invention concerns lancets with a lancet needle, the tip of the lancet needle being embedded in an elastic material. Furthermore the invention concerns lancets where the tip of the lancet needle is surrounded by a hollow body which partially consists of an elastic material that can be pierced by the tip of the lancet needle during the lancing process and which reseals the tip of the lancet needle in the hollow body when it is retracted.
Roche Diabetes Care, Inc.

Biological information measurement system and biological information measurement method

A biological information measurement system includes a light emitting portion, a light receiving portion, a light detection portion, a wireless transmission portion, a reception portion that receives information to specify a change corresponding to an increase or a decrease in the concentration or the amount of hemoglobin, wirelessly transmitted from the wireless transmission portion, and a determination portion that monitors information regarding a change in a blood flow based on the information for specifying a change corresponding to an increase or a decrease in the concentration or the amount of hemoglobin, received by the reception portion, over time, and determines whether or not a rate of the change in a blood flow exceeds a predetermined reference value in a case where there is a change in the information regarding a change in a blood flow according to a timing of chest compressions of the subject.. .
Trilobite Co., Ltd.

System and tracking signal of wire

The system includes a stand surrounding a working area, a signal detector receiving a signal generated by the wire, and a positioning module disposed on the stand. The positioning module is configured to drive the signal detector moving forward and backward on a two-dimensional plane in the working area.
Metal Industries Research & Development Centre

Method and detecting atrial fibrillation

A method of detecting atrial fibrillation includes detecting a pulse signal to obtain a time pulse waveform and converting it to an energy spectrum waveform via fast fourier transform. The energy spectrum waveform includes a first frequency region, a second frequency region, and a third frequency region.

A device and non-invasive left ventricular end diastolic pressure (lvedp) measurement

The present application relates to systems and methods for non-invasively determining at least one of left ventricular end diastolic pressure (lvedp) or pulmonary capillary wedge pressure (pcwp) in a subject's heart, comprising: receiving, by a computer, a plurality of signals from a plurality of non-invasive sensors that measure a plurality of physiological effects that are correlated with functioning of said subject's heart, said plurality of physiological effects including at least one signal correlated with left ventricular blood pressure and at least one signal correlated with timing of heartbeat cycles of said subject's heart; training a machine learning model on said computer using said plurality of signals for periods of time in which said plurality of signals were being generated during a heart failure event of said subject's heart; determining said lvedp or pcwp using said machine learning model at a time subsequent to said training and subsequent to said heart failure event.. .
Boston Scientific Scimed Inc.

Combined physiological sensor systems and methods

A combined physiological sensor and methods for detecting one or more physiological characteristics of a subject are provided. The combined sensor (e.g., a forehead sensor) may be used to detect and/or calculate at least one of a pulse blood oxygen saturation level, a regional blood oxygen saturation level, a respiration rate, blood pressure, an electrical physiological signal (eps), a pulse transit time (ptt), body temperature associated with the subject, a depth of consciousness (doc) measurement, any other suitable physiological parameter, and any suitable combination thereof.
Covidien Lp

Photoacoustic, noninvasive, and continuous blood glucose measurement device

A photoacoustic, noninvasive, and continuous blood glucose measurement device includes: a diode laser for irradiating a living body with a pulsed laser signal having a specific wavelength; and an ultrasound transducer for measuring a photoacoustic signal in a form of ultrasonic waves generated by a reaction of the living body with the pulsed laser signal.. .
Postech Academy-industry Foundation

Apparatus and measuring blood flow of vessels

An apparatus and a method for measuring blood flow of vessels are provided. A light source, a light splitting module, a reference arm module, a sample arm module, a probing module, and a control system are arranged; the sample arm module includes a scanning unit and an optical-path shifting device; a probe light is obtained from the light splitting module, and a main light of the probe light is on a rotating shaft of the scanning unit; the probe light is reflected by the scanning unit to the optical-path shifting device, when the optical-path shifting device is in a first position and in a second position respectively, the probe light scans a vessel in fundus to obtain a first phase shift signal and a second phase shift signal blood flow rates and total blood flow of all the vessels near an optic disc are determined..
Shenzhen Certainn Technology Co., Ltd.

Blood tracking and delivery devices and methods

A blood tracking and delivery system server has processing circuitry configured to receive blood data at a blood database center, wherein a) the blood data is sorted and indexed into a plurality of database tables, b) each entry of a blood donor data table is cross-referenced to respective indexed entries of a blood classification data table, and c) each indexed entry of a blood recipient data table is cross-referenced to respective indexed entries the blood classification data table; receive a blood supply request; cross-match the blood criteria for the recipient with donor blood criteria from the blood donor data tables; and determine a delivery route for the blood supply cross-matched to the blood recipient destination, where an unmanned aerial vehicle uav is configured to deliver the blood supply to the blood recipient destination.. .

Self correction for spatial orientation and motion of portable clinical analyzers

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof..
Abbott Point Of Care Inc.

Apparatus for extracorporeal blood treatment comprising all-round display

An apparatus for extracorporeal blood treatment comprising a control unit and a display device, wherein the apparatus for extracorporeal blood treatment is equipped with a person locating and identifying device and the person locating and identifying device and the display device are in contact of information exchange with each other via the control unit and the person locating and identifying device is adapted to obtain and to process information about the position of a person being located in the environment of the apparatus for extracorporeal blood treatment, and the display device is adapted to display on a display information in response to the position of the person so that it is visible from the position of the person.. .
B. Braun Avitum Ag

System and determining risk of diabetes based on biochemical marker analysis

A method for predicting risk of gestational diabetes mellitus (gdm) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of pai-2 and stnfr1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing gdm.. .
Wallac Oy

Methods for diagnosis and prognosis of cancers of epithelial origin

Adam 12 expression and activity are up regulated in patients that have cancers of epithelial origin, such as breast cancer, colon cancer, prostate cancer, liver cancer, bladder cancer, pancreatic cancer, ovarian cancer, cervical cancer, lung cancer, and skin cancer, as well as others: accordingly, the present invention is directed to methods for prognostic evaluation, and diagnosis of cancers of epithelial origin. In particular, the presence of adam 12 in a biological sample is indicative of cancer of epithelial origin.
Children's Medical Center Corporation

Blood test method

A blood test method includes providing a blood sample containing an anticoagulant containing an ethylenediaminetetraacetic acid (edta) salt other than a sodium, potassium, or calcium salt of edta, and then measuring a blood count and an electrolyte in the provided blood sample.. .
Arkray, Inc.

Kit for diagnosis of coronary heart disease using multi-metabolites and clinical parameters, and diagnosis of coronary heart disease using the same

The present disclosure relates to a method and a diagnostic kit for diagnosing stable angina and acute myocardial infarction early through simple blood testing and checking of clinical parameters. Unlike conventional diagnostic methods, stable angina can be diagnosed as distinguished from acute myocardial infarction according to the present disclosure by using one diagnostic platform based on the change in the in-vivo levels of biological metabolites having different metabolic pathways and clinical parameters as well as medications affecting the onset and progress of the disease through multivariable analysis..
Korea Institute Of Science And Technology

Automated slide assessments and tracking in digital microscopy

The present disclosure provides methods for automated slide assessments made in conjunction with digital image-based microscopy. Automated methods of acquiring patient information and specimen information from prepared slides, and digitally linking such information into patient-tagged specimen data, are provided.
Abbott Laboratories

Marker for prenatal diagnosis and monitoring

The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal dna present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal dna and in maternal dna and provides these new diagnostic methods, which distinguish fetal dna from maternal dna and detect prenatal disorders based on abnormalities in fetal dna level and methylation status..
The Chinese University Of Hong Kong

Genomic alterations in the tumor and circulation of pancreatic cancer patients

Pancreatic adenocarcinoma has the worst overall mortality of any solid tumor, with only 7% of patients surviving after 5 years. To evaluate the clinical implications of genomic alterations in this low cellularity tumor type, we deeply sequenced the genomes of 101 enriched pancreatic adenocarcinomas from patients who underwent potentially curative resections and used non-invasive approaches to examine tumor specific mutations in the circulation of these patients.
The Johns Hopkins University

Method for preparing natural killer cells using irradiated pbmcs, and anti-cancer cell therapeutic agent comprising the nk cells

Provided is a method for preparing natural killer cell with high efficiency using irradiated peripheral blood mononuclear cells, more particularly to a method for proliferating highly activated nk cells using a combination of irradiated peripheral blood mononuclear cells (pbmcs) and a cd16 antibody and an anti-cancer cell therapeutic composition containing the natural killer cells (nk cells) prepared thereby. Further provided is a method for large-scale proliferation of activated nk cells with high efficiency using a combination of irradiated peripheral blood mononuclear cells (pbmcs) and a cd16 antibody without the use of cancer cells or genetically modified feeder cells having safety issues as feeder cells.
Korea Institute Of Radiological & Medical Sciences

Tfpi inhibitors and methods of use

The invention provides peptides that bind tissue factor pathway inhibitor (tfpi), including tfpi-inhibitory peptides, and compositions thereof. Peptide complexes also are provided.
Baxalta Incorporated

Diaryl isoxazoline compound

The present invention concerns compounds of formula (i) or an n-oxide or salt thereof and their use for controlling parasites in and on warm-blooded animals or fish.. .
Elanco Tiergesundheit Ag

Cationic lipid

Wherein each symbol is as defined in the description, is superior in the stability in blood and tumor accumulation property. A nucleic acid-introducing agent using the cationic lipid can achieve high nucleic acid delivery efficiency of nucleic acid to be delivered into the cytoplasm..

Red blood cell washing system

A blood washing system including a rotor defining an internal chamber and a skimmer assembly configured to move a withdrawal needle within the internal chamber. A multi-component fluid, such as a whole blood sample, can be fed into the internal chamber via a feed tube, where the rotor can be rotated to fractionate the multi-component fluid.

Blood washing and separation system

A separation rotor having an outer wall defining a separation chamber and an inner annular wall dividing the separation chamber into an inner annular space and an outer annular space. The separation rotor can be rotated to move heavier and/or denser components of the multi-component fluid into the outer annular space.

Separators for blood collection tubes

Sample collection tubes and methods of producing the same are provided. Contemplated collection tubes comprise a tube having a separator substance disposed therein.
University Of Maryland

Red blood cell elutriation wash system

A funnel element having an open end and a closed pointed end configured to receive a multi-component fluid containing a solid fraction. The solid fraction can comprise cellular material that sediments toward the closed pointed end to form a cell pack.

Application of high-intensity focused ultrasound system to treatment of essential hypertension

An application of a high-intensity focused ultrasound system to treatment of essential hypertension. A treatment process includes: conducting ultrasonic positioning measurement on both sides of perirenal fat tissue of a patient, setting a therapeutic window and parameters of the system, and setting corresponding power parameter of the system, so as to make local temperature of the tissue during treatment reach 40-70° c., wherein treatment portions are both sides, and treatment scope is one third to all of the whole tissue; starting the system to treat one side of the tissue according to the set parameters and then the other.
Nanjing Khons Medtech Co., Ltd.

Systems and methods for reducing or altering oral bacteria and methods for manufacturing the same

A method and apparatus for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing direct current electricity and methods for manufacturing the same. Electrodes are used to deliver a direct current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits.
Biolectrics Llc

Conductive pad for pain relieving and muscle training

A conductive pad for pain relieving and muscle training, comprises an electrode sheet electrically connected to a control unit and a conductive gel for attaching onto the human body. The conductive gel is added with a substance for pain relieving and muscle training, which is capsaicin, menthol, lidocaine, or other substitutes in an amount of 0.001% to 30% by mass.
Jkh Health Co., Ltd.

Length-adjustable catheter and method that employs a length-adjustable catheter to treat vascular pathologies

The current document is directed to length-adjustable catheters and methods that employ length-adjustable catheters to treat malformations, constrictions, obstructions, lesions, and blockages within patients' blood vessels. The length of the shaft of a length-adjustable catheter, to which the current application is directed, can be adjusted over a range of lengths prior to and during medical procedures.
Cti Vascular Ag

Congestive heart failure therapy device

Provided is a congestive heart failure therapy device that applies a positive pressure within an optimal range depending on the condition of a congestive heart failure (chf) patient. Provided is a positive pressure therapy device for congestive heart failure patients, comprising: a pressure raising unit configured to raise the pressure of air, or a gas mixture of air and other gases, to a positive pressure; an introducing unit configured to introduce the air or the gas mixture set to a positive pressure into the airways of the patient; and a blood oxygen level measurement unit configured to measure the blood oxygen level of the patient, a blood flow rate measuring unit configured to measure a blood flow rate of the patient, or a cardiac output measuring unit configured to measure a cardiac output of the patient.
Teijin Pharma Limited

Composite fluid separation

Embodiments are described that include systems and methods for separating components of a composite fluid, e.g., whole blood. Some embodiments provide for processing a composite fluid by subjecting a volume of the fluid to a first centripetal acceleration for an initial separation, followed by a second centripetal acceleration for a second separation..
Terumo Bct, Inc.

Devices, methods, and systems for priming, separating, and collecting blood components

A photopheresis system (200) is disclosed, and that may be configured to execute one or more protocols. These protocols include: 1) protocols (400; 430; 460) for purging air out of a centrifuge bowl (210) used by the photopheresis system (200); 2) protocols (500; 510 550) for assessing the installation/operation of one or more pressure domes (330) used by the photopheresis system (200); and 3) protocols (580; 600; 660; 700; 740) for collecting buffy coat from blood processed by the photopheresis system (200)..
Mallinckrodt Hospital Products Ip Limited

System and removing fat from salvaged blood

A method for removing fat from salvaged blood includes transferring salvaged blood from a reservoir to a blood component separation device, and separating the blood into a plurality of blood components. The method may then transfer a volume of unwashed blood components from the blood component separation device back toward the reservoir, and recentrifuge the blood components remaining within the blood component separation device.
Haemonetics Corporation

Methods and devices for removal of immunosuppressive ligands

The present disclosure relates to methods of removing soluble nkg2d ligands, including soluble mica, soluble micb and soluble ulbp proteins, from blood to treat diseases characterized by abnormal levels of soluble nkg2d ligands. Further provided are systems and devices for carrying out the therapeutic methods..
Novelogics Biotechnology, Inc.

Methods and systems for establishing retrograde carotid arterial blood flow

Interventional procedures on the carotid arteries are performed through a transcervical access while retrograde blood flow is established from the internal carotid artery to a venous or external location. A system for use in accessing and treating a carotid artery includes an arterial access device, a shunt fluidly connected to the arterial access device, and a flow control assembly coupled to the shunt and adapted to regulate blood flow through the shunt between at least a first blood flow state and at least a second blood flow state.
Silk Road Medical, Inc.

Dialysis catheter

A dialysis catheter including a first portion having a first diameter, an elongated distal portion having a second smaller diameter, and a transition portion the first portion includes first and second independent blood withdrawal lumens extending in the first portion, the first withdrawal lumen terminating in the transition portion in a first terminal opening and the second withdrawal lumen terminating in a second terminal opening, the first and second terminal openings being radially spaced and axially adjacent. A longitudinally extending blood delivery lumen extends in the first portion and terminates in a delivery opening in the distal portion of the catheter, the first and second terminal openings positioned proximally of the delivery opening and each of the first and second terminal openings having a curved wall surrounding a portion of the terminal opening..
Argon Medical Devices, Inc.

Control system

A control system for controlling a quantity of blood in a blood reservoir (10) of a perfusion system supplied by a venous line (v), wherein a pump (20) circulates blood from the blood reservoir (10) through an outgoing line(a), comprises a venous flow sensor (22) to measure a venous blood flow rate,an outlet flow sensor (24) to measure an outgoing blood flow rate, and a controller to control the pump (20) to prevent the outgoing blood flow rate from exceeding the venous blood flow rate. Thereby,a decrease of blood in the blood reservoir(10) can be arrested..
Spectrum Medical Ltd.

Dialysis machine

A disposable cartridge for use in a hemodialysis machine has a blood flow path for carrying a volume of blood to be treated in a dialyser and a dialysate flow path, isolated from the blood flow path, for delivering a flow of dialysate solution through the dialyser. The cartridge is received in an engine section of the machine.
Quanta Dialysis Technologies Limited

Aortic pump devices and methods

A disclosed apparatus or method can include or use a non-transluminally implantantable blood pump housing, which can be sized and shaped to be implanted at an aortic valve of a human subject, the pump housing can include: a pump housing cross-sectional profile size that is larger than is passable via a blood vessel of the human subject; and a power connection, configured for being electrically connected to an intravascular lead that is sized and shaped to extend from the pump housing through a subclavian artery of the human subject.. .
Berlin Heart Gmbh

Self-contained heart pump

A heart pump includes a rotative impeller partly inserted into the systemic ventricle, this rotative impeller being equipped with a membrane sutured to the outer wall of the heart in such a way as to secure the rotative impeller to the wall of the heart, a housing arranged inside the systemic ventricle in such a way as to draw up then discharge blood, a motor connected to the housing and arranged partly outside the systemic ventricle in such a way as to facilitate maintenance; an integrated management unit in the epigastric region including a power supply and a rotative impeller control unit; and a wired link between the management unit and the rotative impeller.. .
Fineheart

Blood component pooling device, system and method

A device for pooling a blood component stored in source containers includes a pump or pumps configured to pump a fluid in a first direction and a second direction and receive a pump line having a first end connected to the source containers. A pool clamp is configured to receive a pool line having a first end connected to a second end of the pump line and a second end connected to a pool container.
Fenwal, Inc.

Filter element for blood processing filter and blood processing filter

The present invention provides a filter element for a blood processing filter, comprising a nonwoven fabric, wherein the quantity of crystallization heat of the uncrystallized portion of the nonwoven fabric is 5 j/g or smaller before steam heat treatment.. .
Asahi Kasei Medical Co., Ltd.

Glycemic control using intrinsic factor bound to a vitamin b12 conjugate of a glucagon-like peptide-1 receptor agonist

The present invention provides compositions and methods for lowering blood glucose. More specifically, the present invention provides compositions comprising a complex comprising if and b12 conjugated to a peptide comprising a glp-1 agonist.
Syracuse University

Methods of reducing extravasation of inflammatory cells

A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue.
Acorda Therapeutics, Inc.

Composition and uses thereof

The invention relates to compositions comprising pinus pinaster stem bark extract, papain, and aloe vera extract, and methods of manufacturing same. There are also described methods of treating or preventing a variety of conditions, including treating or preventing elevated blood glucose, pre-diabetes, type 2 diabetes, autoimmune diseases, reducing or decreasing inflammation, treating or preventing diseases characterised by elevated levels of inflammation, and lowering blood cholesterol, said methods comprising administering an effective amount of a composition according to the invention to a subject in need thereof.
Arborvitae Health And Wellbeing Pty. Ltd.

Methods for detecting risk of having a bloodstream infection and compositions for reducing the risk

Provided herein is a method for determining the relative abundance of total bacterial in a sample. Optionally, the method also includes determining whether the subject has a risk of bloodstream infection after chemotherapy, such as a chemotherapy used to prepare a subject for a hematopoietic stem cell transplantation procedure.
Centre Hospitalier Universitaire De Nantes

Treatment of graft versus host disease in transplant patients

The present invention relates to a method of treating patients who undergo hematopoietic stem cell transplantation (hsct) with peripheral blood mobilized stem cells for hematological malignancies and for whom the risk for severe acute graft versus host disease (gvhd) is considerable.. .
Kyorin Pharmaceutical Co., Ltd.

Treating vasculature related diseases or disorders using nanoparticles

The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder.
The Regents Of The University Of California

Spray-dried blood products and methods of making same

The present invention is directed to a method of preparing dehydrated blood products, comprising the steps of: (a) providing a hydrated blood product; (b) spray-drying the hydrated blood product to produce a dehydrated blood product, as well as dehydrated blood products made by the method. The present invention is directed to a method of treating a patient suffering from a blood-related disorder, comprising the steps of: (a) rehydrating a therapeutic amount of the dehydrated blood products to produce a rehydrated therapeutic composition; and (b) administering the rehydrated therapeutic composition to the patient.
Entegrion, Inc.

Stable glucagon peptide formulations

There is provided glucagon formulations suitable for preparing coatings on microneedle patches for the transdermal delivery of glucagon. The coated patches may be used for the treatment of low blood sugar in diabetic patients.
Zp Opco, Inc.

Vascular implant

A vascular graft configured for occluding a vasculature of a patient including a biocompatible polymeric textile structure formed of a plurality of filaments spaced to enable blood flow through spaces between the filaments. The textile structure forms a tubular body having a first longitudinally extending opening.
Naurogami Medical, Inc.

Intravascular stent and manufacturing method thereof

Disclosed herein is an intravascular stent for being implanted into blood vessels and a method for manufacturing the same. The intravascular stent is woven by at least one weaving wire, and the stent is in a tubular structure.
Suzhou Innomed Medical Device Co., Ltd.

Ivc filter with translating hooks

A filter with translating hooks is described. The filter can include strut members having first and second struts connected by a connecting portion.
C.r. Bard, Inc.

Method and invasive device tracking using organ timing signal generated from mps sensors

Apparatus for generating an organ timing signal relating to an inspected organ within the body of a patient, including a medical positioning system, and a processor coupled with the medical positioning system, the medical positioning system including at least one reference electromagnetic transducer placed at a reference location, at least one inner electromagnetic transducer attached to a surgical tool inserted in a blood vessel in the vicinity of the inspected organ, and a medical positioning system processor coupled with the reference electromagnetic transducer and the inner electromagnetic transducer, the medical positioning system processor determining the three-dimensional position of the inner electromagnetic transducer, by processing transmitted electromagnetic signals transmitted from one of the reference electromagnetic transducer and the inner electromagnetic transducer with detected electromagnetic signals detected by the other of the reference electromagnetic transducer and the inner electromagnetic transducer, the medical positioning system processor further generating medical positioning system data sets, each of the medical positioning system data sets including a collection of three-dimensional position coordinate readings demonstrating the motion trajectory of the surgical tool over time, the processor generating the organ timing signal from the medical positioning system data sets by detecting and identifying periodic motion frequencies in the medical positioning system data sets, and filtering the periodic motion frequencies from the medical positioning system data sets.. .
Mediguide Ltd.

Shock wave balloon catheter with insertable electrodes

A translatable shock wave treatment apparatus is suitable for use in treating calcified lesions in vascular structures having small diameters. An elongate member carrying a collapsed angioplasty balloon is first inserted into the occluded blood vessel.
Shockwave Medical, Inc.

Tissue sampling devices, systems and methods

Methods, devices, and systems are described herein that allow for improved sampling of tissue from remote sites in the body. A tissue sampling device comprises a handle allowing single hand operation.

Devices and methods for collecting and stabilizing biological samples

The present invention generally relates to devices and methods for collecting and stabilizing biological samples, and more particularly, for collecting and stabilizing blood or other bodily fluids from a user's fingertip, earlobe, heel or other locations. The present invention also relates to sample collection devices that simplify the process for mixing the biological samples with an additive or additives, provide for efficient storage and safe transport of the samples, and provide for easy access to the samples for subsequent processing..
Dxterity Diagnostics Incorporation

Stand-alone continuous cardiac doppler pulse monitoring patch with integral visual and auditory alerts, and patch-display system and method

A stand-alone continuous cardiac doppler pulse monitoring patch provides visual and auditory signals that a pulse is detected or not detected in a human subject. The invention is a small patch with a peel-away adhesive surface that is applied to the skin of the subject, preferably near a large artery.

Synthetic data-driven hemodynamic determination in medical imaging

In hemodynamic determination in medical imaging, the classifier is trained from synthetic data rather than relying on training data from other patients. A computer model (in silico) may be perturbed in many different ways to generate many different examples.
Siemens Healthcare Gmbh

Stroke detection using blood pressure surge

This document discusses, among other things, systems and methods for detecting stroke. A system may comprise a sensor circuit for sensing a physiological signal, and a second sensor to detect a physical state change.
Cardiac Pacemakers, Inc.

Arterial and venous blood metrics

A medical device including a probe configured to be orally inserted into a lumen extending into the thorax of the subject, a plurality of electrodes, and a control circuit. The probe includes a first electrode.
Zoll Medical Corporation

Apparatus and measuring biologic parameters

Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body.
Geelux Holdings, Ltd.

Method and vital signs measurement

A method of monitoring changes in oxygen saturation of a subject by analysing a three colour channel video image of the exposed skin of the subject. Within each colour channel a normalised signal obtained by dividing the intensity signal by its mean value, and the normalised signals are averaged across plural regions of interest within the exposed skin area image of the subject.
Oxford University Innovation Limited

Analyte sensor receiver apparatus and methods

Receiver apparatus for use with an analyte sensor, and methods of operation and manufacturing. In one embodiment, the analyte sensor is an implanted/implantable blood glucose sensor, including oxygen-based detector elements.
Glysens Incorporated

Opticoustic sensor

A physiological sensor has an optic assembly, an acoustic assembly and an attachment assembly. The optic assembly has an optic transducer that is activated so as to transmit a plurality of wavelengths of light into a tissue site and to detect the light after attenuation by pulsatile blood flow within the tissue site.
Masimo Corporation

System and methods for respiratory measurements using breathing gas samples

There is provided a method that includes receiving pulse-oximetry measurements (spo2) of a patient's peripheral arterial blood oxygen saturation during a first time period, and receiving breathing samples of the patient. The method further includes determining, using breathing samples of the patient, oxygen partial pressure measurements (pao2) and carbon dioxide partial pressure measurements (paco2) from exhaled air of the patient during a steady-state breathing of the patient during the first time period.
Medipines Corporation & The Regents Of The University Of California

Cuff designs and methods

A low-profile blood pressure measurement system and methods of use are disclosed. The system includes an expandable member or structure that has a multi-compartment structure and/or is mounted on a rigid surface or structure.
Apple Inc.

Aortic stenosis classification

According to one implementation, a medical device includes a display, a blood pressure sensor for sensing an arterial blood pressure of a patient and for generating a blood pressure signal, an analog-to-digital converter (adc) for receiving the blood pressure signal and for converting the blood pressure signal to blood pressure data in digital form, and a hardware processor for executing an aortic stenosis diagnostic software code. The hardware processor executes the aortic stenosis diagnostic software code to receive the blood pressure data from the adc, and to identify parameters indicative of aortic stenosis in the patient, based on the blood pressure data.
Edwards Lifesciences Corporation

Near-infrared lasers for non-invasive monitoring of glucose, ketones, hba1c, and other blood constituents

An imaging device includes laser diodes (lds) generating near-infrared wavelength light, lenses configured to deliver the light to tissue, a first receiver having one or more detectors, and a first part with at least one of the lds capable of being pulsed. The first receiver receives light reflected from the tissue and is synchronized to the pulsed light and configured to perform a time-of-flight measurement.
Omni Medsci, Inc.

Folic acid, metal complexes for rumen by-pass nutritional supplementation of ruminants

A method and composition for dietary supplementation of ruminants with folic acid in a manner that assures the folic acid will not be consumed by rumen bacteria and instead will pass through to the intestine and to the animal's blood serum in order to enhance milk production. The folic acid in water is mixed with a water soluble metal salt of zinc, copper, iron or manganese or mixtures thereof to form a metal folate complex..
Zinpro Corporation

Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status

The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
Transmedics, Inc.

Gas depletion and gas addition devices for blood treatment

Devices for the preparation of depleted blood products that provide for the depletion of oxygen, carbon dioxide, or oxygen and carbon dioxide are described. In addition, devices for the replenishment of oxygen and other gases to an anaerobic blood product are described.
New Health Sciences, Inc.

Medical guide element with diameter transition

Improved methods for percutaneously creating, entering and/or dilating an opening in the wall of a blood vessel or other anatomic structure. The improvement comprises deploying a guide element having a proximal segment and a distal segment, the diameter of said distal segment being greater than the diameter of said proximal segment at their juncture, and which at said juncture forms an abrupt circumferential step comprising a proximally-facing surface.
Suphatchatwong Innovation Co., Ltd.

. .

. .

Wireless pairing of personal health device with a computing device

Systems and methods for the wireless pairing of a personal health device (phd) (e.g., blood glucose monitor) with a computing device (e.g., smartphone) are disclosed herein. In an embodiment, the phd communicates a private key to the computing device via a first communication medium (e.g., light signal, audio signal, pattern).
Trividia Health, Inc.

Dual-display smart watch with proximal and distal (analog and electronic) displays

This invention is a dual-display smart watch with a proximal dorsal display and a distal dorsal display. In an example, the proximal and distal displays can both be electronic displays.
Medibotics Llc

Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method

The present invention is directed to a cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, in particular a blood sample, comprising a cartridge body having at least one measurement cavity formed therein and having at least one probe element arranged in said at least one measurement cavity for performing a test on said sample liquid; and a cover being attachable on said cartridge body; wherein said cover covers at least partially said at least one measurement cavity and forms a retaining element for retaining said probe element in a predetermined position within said at least one measurement cavity. The invention is directed to a measurement system and a method for measuring viscoelastic characteristics of a sample liquid..
C A Casyso Gmbh

A device for visual detection of bilirubin

The present invention discloses a diagnostic device or kit for visual detection of bilirubin. Said diagnostic device or kit comprises chitosan stabilized gold nanoclusters based luminescence source, cu2+ ions source for quenching luminescence intensity of said gold nanoclusters and recovery of quenched luminescence intensity in the presence of bilirubin.
Indian Institute Of Technology, Guwahati

Analysis of cell-free dna in urine and other samples

Diseases (e.g., cancer) of a particular organ can be detected by analyzing cell-free dna. Some embodiments may use an organ-associated sample that is from a particular organ or passes through the particular organ, as may occur, for example, in urine, saliva, blood, and stool samples.
The Chinese University Of Hong Kong

Sensor

The present invention provides a urine analyzer comprising: a. At least one discrete test area configured to perform a colorimetric test specific for an analyte selected from the group consisting of glucose, protein, ph, blood, ketone bodies, bilirubin, and any combination thereof, wherein each discrete test area is configured to perform a different colorimetric test; b.
Expro3, Llc.

Device and detecting creatinine and albumin to creatinine ratio

An electrochemically active, creatinine-binding device is provided to detect and measure quantitatively, creatinine in biological samples. The device of the present invention is also provided with a device to detect and measure quantitatively creatinine and albumin bioanalytes, simultaneously and to determine albumin to creatinine ratio (acr).
Indian Institute Of Science

Flowcell particle analysis in blood samples

The present disclosure relates to apparatus, systems, compositions, and methods for analyzing a sample containing particles. In some aspects the system comprises an analyzer which may be a visual analyzer.
Iris International, Inc.

Rotor for a fluid pump and method and mold for the production thereof

The invention relates to a rotor for a compressible fluid pump, in particular a blood pump that can be introduced through a blood vessel into a patient's body, wherein said rotor comprises one or more conveying elements (15), is compressible and expandable between a first compressed state and a second radially expanded state, is made at least partially from a plastic reinforced with reinforcing elements, in particular fibers (10, 11, 13, 18, 19, 55, 56, 62, 63) and is provided for rotation about an axis of rotation (14). According to the invention, the rotor is tensioned in the first, compressed state and free from external stresses in the second, expanded state.
Ecp Entwicklungsgesellschaft Mbh

Rotor for a fluid pump, and method and mold for manufacturing same

Disclosed is a rotor for a compressible fluid pump, in particular a blood pump that can be introduced into a patient's body through a blood vessel; said rotor comprises one or more impeller elements, is compressible and expansible between an expanded state and a compressed state, is made at least in part of a fiber-reinforced plastic material, is provided for rotating about an axis of rotation, and is characterized in that in the expanded state of the rotor, a first percentage, i.e. More than 30%, in particular more than 50%, of the fibers runs substantially straight between the first end thereof lying closest to the axis of rotation and a second end lying further away from the axis of rotation.
Ecp Entwicklungsgesellschaft Mbh

Method for predicting treatment efficacy of peginterferon plus ribavirin treatment in a subject suffering from hepatitis c

The present invention provides a method for predicting treatment efficacy of peginterferon plus ribavirin treatment in a subject suffering from chronic hepatitis c comprising: (a) measuring gene expression levels of genes comprising rsad2, loc26010, herc5, herc6, ifi44, serping1, ifitm3 and ddx60 of a blood sample from the subject after one week of the peginterferon plus ribavirin treatment; and (b) calculating a gene score according to cumulative fold change of the gene expression levels, when the gene score is equal to or higher than a cut-off value, the method predicts successful treatment of chronic hepatitis c with the peginterferon plus ribavirin treatment for the subject.. .
Kaohsiung Medical University

Blood-based biomarkers of tumor sensitivity to pd-1 antagonists

The present disclosure describes baseline and on treatment blood-based gene signature biomarkers that are predictive of tumor sensitivity to therapy with a pd-1 antagonist. The on-treatment biomarkers comprise a pd-l1 gene signature or an interferon gamma gene signature and the baseline gene signature biomarker comprises genes associated with the oxidative phosphorylation pathway.
Merck Sharp & Dohme Corp.

Method for determining the risk of bronchopulmonary dysplasia of preterm infants

Provided is a method for determining the risk of bronchopulmonary dysplasia (bpd) of a preterm infant. The method comprises detecting the expression level of ephb2 in a primary culture of mesenchymal stem or stromal cells (mscs) derived from a placenta-related tissue of the infant's mother or umbilical cord blood of the infant..
Meribank Biotech Co., Ltd.

Bacterial detection cartridge

Described herein are methods and apparatus for rapid detection of microorganisms in biological samples (e.g. Blood) for analysis to determine the presence or absence of infectious microorganisms in the samples.
Becton Dickinson And Company

Method for producing blood coagulation factor vii, and blood coagulation factor vii

A process for producing blood coagulation factor vii in 3 human cell lines (hepg2, sk-hep, hkb-11) and to select the best recombinant protein producer. The murine line bhk-21 was used as control.
FundaÇÃo Hemocentro De RibeirÃo Preto - Fundherp

Methods of isolating t cells and t cell receptors having antigenic specificity for a cancer-specific mutation from peripheral blood

Disclosed are methods of isolating t cells and tcrs having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation. Also disclosed are related methods of preparing a population of cells, populations of cells, tcrs, pharmaceutical compositions, and methods of treating or preventing cancer..
The United States Of America,as Represented By The Secretary,department Of Health And Human Service

Generating induced neural progenitor cells from blood

The present disclosure provides a method of generating induced neural progenitor cells from cd34+/cd45+ blood cells using a pou domain containing gene or protein and inhibitors of smad and gsk-3β, without traversing the pluripotent state. Also provided are uses and assays of the cells produced by the methods of the disclosure..
Mcmaster University

Novel hybrid actriib ligand trap proteins for treating muscle wasting diseases

The present disclosure describes novel hybrid soluble actriib-ecd polypeptides which fully retain binding affinity for myostatin and activin a but demonstrate significantly reduced binding to bmps, especially bmp-9. The novel compositions described herein can be used to prepare novel hybrid actriib ligand trap proteins, which can be used for modulating the growth of muscle, bone, cartilage, fat, fibroblast, blood and neuronal tissue to counteract muscle wasting, bone loss, anemia, inflammation and fibrosis in a therapeutically meaningful manner.
Alivegen Usa, Inc.

System for portable and easy-to-use detection of analytes with mobile computing device

This system takes in raw cellular material collected using a provided swab, blood collection device, urine collection device, or other sample collection device and transforms that biological material into a digital result, identifying the presence, absence and/or quantity of nucleic acids, proteins, and/or other molecules of interest.. .
Cue Inc.

Methods and devices for treating erectile dysfunction

Methods and devices for treating erectile dysfunction are disclosed. Methods are aimed at reducing blood outflow from penile tissue by delivering energy to specific penile tissue that controls blood outflow from the penile tissue and causing remodeling of the specific penile tissue.
Ohh- Med Medical Ltd.

Medical electrical lead having biological surface and methods of making and using same

An implantable electrical lead suitable for left sided cardiac placement, the implantable medical electrical lead having an external blood contacting surface having an external coating including a monolayer of at least one biological agent that promotes endothelialization covalently attached to a polymeric lead surface.. .
Medtronic, Inc.

Vascular catheter permitting the injection of a volume of the plug type

The present invention relates to a single-lumen vascular catheter (1) to be inserted into a blood flow channel for the injection of a product by the venous or arterial route, comprising a tube (2) having a hollow longitudinal body with a lumen (3), the lumen (3) extending along the full length of the tube (2) and being intended to permit the injection of a given volume (4) of product at a prescribed flow rate the tube (2) having lateral orifices (5) which are of substantially identical size and are arranged in the longitudinal body substantially symmetrically about the longitudinal axis, near a distal end (6) of the tube (2), an end surface (7) at the distal end (6) of the tube (2) reducing a total surface area of the lumen (3) starting from the distal end (6) of the tube (2).. .
Centre National De La Recherche Scientifique (cnrs)

Slack-time heating system for blood and fluid warming

Presented herein are various systems, methods, and apparatuses for heating infusate by an induction heater e.g., an electromagnetic heater, and storing thermal energy in a reservoir of thusly heated infusate. In certain embodiments, a system includes a reservoir for containing an infusate, a fluid heater, a diversion valve, a patient line, and a recirculation line..
Belmont Instrument, Llc

Rapid infuser with advantageous flow path for blood and fluid warming

Presented herein are a system for heating fluid, which, in certain embodiment, comprises a fluid separator, a conduit, and a plurality of inductors. The system demonstrates a single flow path without compromising advantages of the existing blood warmers, such that the heat exchanger would not experience stagnant flow that may cause overheating of a local flow path..
Belmont Instrument, Llc

Method and system for a hybrid control-to-target and control-to-range model predictive control of an artificial pancreas

Described and illustrated is a system for management of diabetes that includes an infusion pump, glucose sensor and controller with a method programmed into the controller. The infusion pump is configured to deliver insulin to a subject.
Animas Llc

Arrangement with a blood pump and a gas exchanger for extracorporeal membrane oxygenation

The invention relates to an arrangement having a blood pump and a gas exchanger for extracorporeal membrane oxygenation. According to the invention, the blood pump is designed as a pulsatile blood pump and is arranged with the gas exchanger in the same housing.
Hemovent Gmbh

Apparatus for performng an extracorporeal blood treatment

An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32); a control unit (12) is configured for calculating a sodium concentration value for the blood; the estimation of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the isoconductive sodium concentrate and of an offset contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate and phosphate.. .
Gambro Lundia Ab

Devices, methods and systems for establishing supplemental blood flow in the circulatory system

Devices, systems and methods for establishing a blood flow conduit between a chamber in a heart of a patient and a remote location. A blood inflow cannula having an outer surface and proximal and distal end portions.
Circulite, Inc.

Patient behavior sensitive controller

A method of controlling an implantable blood pump of a living patient. The method includes receiving one or more pump signals indicating at least one from the group consisting of a motor speed of the blood pump, power supplied to the blood pump, and differential pressure exerted by the blood pump.
Heartware, Inc.

System for ventricular circulatory support

The invention relates to a system for ventricular circulatory support, comprising a device (2) for applying a magnetic field to a magnetised body fluid (1), particularly blood, in a region of a vessel (3), particularly a blood vessel. The system also comprises a control device designed to actuate said device (2) for applying a magnetic field such that, in the region of the vessel (3), a magnetically-induced force acts on the magnetised body fluid (1) in the longitudinal direction of said vessel (3)..

Compositions and methods for monitoring biometric indicators

Methods of measurement of biometric indicators in a mammalian subject are described. Biometric indicators of interest include hematocrit, plasma volume, volume of distribution, and glomerular filtration rate.
Pharmacophotonics, Inc.

Compositions and methods for delivery of agents

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo..
Modernatx, Inc.

Systems and methods for sympathetic cardiopulmonary neuromodulation

Methods, devices and systems are described for decreasing the activity of the sympathetic nervous innervation to and from the lungs and the vessels supplying the lungs to treat pulmonary medical conditions such as asthma. In one embodiment, the method may involve advancing an intravascular instrument to a target location in a blood vessel within the intercostal vasculature to ablate either or both the sympathetic afferent and efferent nerves lying within the paravertebral gutter including the visceral fibers that travel to the cardiothoracic cavity and abdominopelvic viscera and the t1 to t4/5 sympathetic chain.
Reflex Medical, Inc.

Method for preparing broccoli protein peptide, broccoli protein peptide prepared therefrom and use thereof

Provided is a method for preparing a broccoli protein peptide. The method uses a broccoli protein as the raw material, and obtains a broccoli protein peptide powder through the steps of preprocessing, enzymatic hydrolysis, terminating enzymatic hydrolysis, separation, and drying and the like.
Zhejiang Teley Biotechnology Co., Ltd.

Trans10:cis12 isomer of conjugated linoleic acid as a therapeutic and preventative agent for hypertension specific to pregnancy

Described herein are compositions and methods for the use of t10:c12 conjugated linoleic acid to reduce hypertension in pregnant women. Advantageously, by reducing blood pressure, the compositions will also reduce the risk of pre-term birth.
Wisconsin Alumni Research Foundation

Intravascular delivery of nanoparticle compositions and uses thereof

The present invention provides methods of delivering a composition comprising nanoparticles that comprise a macrolide and an albumin by directly injecting the nanoparticle composition into the blood vessel wall or the tissue surrounding the blood vessel wall. The methods can be used for inhibiting negative remodeling or vascular fibrosis in the blood vessel and are useful for treating various diseases..
Abraxis Bioscience, Llc

Medical protocol for improving human sexual function

A medical procedure for improving human sexual function in a patient is disclosed. The medical procedure includes drawing blood from the patient, processing the blood that was drawn to produce platelet rich plasma (prp) from said blood, and anesthetizing a portion of a penile shaft of a male patient or anesthetizing a portion of a vulva and an anterior vaginal wall of a female patient.
The Anti-aging Group, Llc

Procedures for vascular occlusion

A method of reducing blood flow within an aneurysm includes: injecting a contrast agent into a blood vessel including an aneurysm; expanding a stent, from a delivery device, across the aneurysm; and confirming that a stagnated area forms in the aneurysm. The stagnated area can form a crescent shape, a mushroom shape, a hemispherical shape, and/or a flat side.
Covidien Lp

Paravalvular leak sealing mechanism

A collapsible and expandable stent body includes a generally tubular annulus section, one or more prosthetic valve elements mounted to the stent body, and a cuff attached to the stent body. The prosthetic valve is operative to allow flow in an antegrade direction but to substantially block flow in a retrograde direction.
St. Jude Medical, Cardiology Division, Inc.

Process for the preparation of a topography for improved blood coagulation and/or cell attachment on a body made of titanium or a titanium alloy

A process for the preparation of a topography for improved blood coagulation and/or cell attachment on a body made of titanium or a titanium alloy. The process includes the subsequent steps of: a) etching at least a portion of the surface of the body with a first etching solution including a mineral acid, and b) etching the surface etched under a) with a second etching solution different than the first etching solution, the second etching solution including hydrofluoric acid..
Straumann Holding Ag

Method and treating a patient by intentionally occluding a blood vessel, including inducing weight loss in a patient by intentionally occluding the celiac artery

Intentionally occluding a blood vessel so as to create hypoperfusion in a gastrointestinal organ serviced by the blood vessel, whereby to interfere with normal gastrointestinal function and thereby induce weight loss in a patient.. .

Ultrasonic blood flow imaging display method and ultrasonic imaging system

An ultrasonic blood flow imaging display method and an ultrasonic imaging system. The system comprises: a probe (1); a transmitting circuit (2), configured to excite the probe (1) to transmit an ultrasonic beam to a scanning target; a receiving circuit (4) and a beam forming module (5), configured to receive an echo of the ultrasonic beam to obtain an ultrasonic echo signal; a data processing module (9), configured to obtain, according to the ultrasonic echo signal, blood flow velocity vector information and doppler blood flow velocity information about a target point in the scanning target and at least part of ultrasonic images of the scanning target, and superposing the ultrasonic images and the doppler blood flow velocity information to form a doppler color blood flow graph; and a display (8), configured to contrastively display the blood flow velocity vector information and the doppler color blood flow graph.
Shenzhen Mindray Bio-medical Electronics Co., Ltd.

Medical image-processing apparatus, x-ray ct apparatus, and medical image-processing method

A medical image-processing apparatus according to embodiments includes processing circuitry. The processing circuitry is configured to acquire image data including a blood vessel of a subject.
Toshiba Medical Systems Corporation

System for the localized measurement of radiotracer in the body

Various embodiments of a device for in-vivo measurements radiopharmaceuticals used for diagnosis and radiotherapy is presented. In some embodiments, the present disclosure relates to a scintillation device having a cannula that may include scintillation material and a delivery lumen, wherein the device may be used to both deliver material to the patient (e.g., deliver radiotracers used in radiopharmaceuticals) and measure levels of radioactive material in, for example, the patient's blood both during and after administration of the radioactive material.
Lucerno Dynamics, Llc

Noise reduction processing circuit and method, and biological information processing device and method

A noise reduction processing circuit of the disclosure includes an adaptive filter that receives, as an input signal, a body motion signal that is filtered on a basis of a transfer function, that is calculated by modeling an influence of body motion on a blood flow, and a subtractor that outputs an error signal obtained by subtracting an output value of the adaptive filter from an observed signal.. .
Sony Corporation

Apparatus and system for diabetes management

An apparatus and system diabetes management. The apparatus comprises a body which houses: (i) at least a first memory for storing data inputs corresponding at least to one or more components in a patient's present insulin dosage regimen and the patient's blood-glucose-level measurements determined at a plurality of times; (ii) a processor operatively connected to the at least first memory, the processor programmed at least to determine from the data inputs corresponding to the patient's blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the one or more components of the patient's present insulin dosage regimen; (iii) a display screen operatively connected to the processor, (iv) a quantity of insulin; (v) a needle communicating with the quantity of insulin for delivering insulin to the patient; (vi) means for effecting delivery of a portion of the quantity of insulin to the patient via the needle; and (vii) metering means for controlling the portion of the quantity of insulin delivered to the patient via the needle..
Hygieia, Inc.

Sensor for depth of anesthesia and cerebral blood oxygen saturation

Provided is an integrated depth-of-anesthesia/cerebral-oxygen-saturation detection sensor. Particularly, the depth-of-anesthesia/cerebral-oxygen-saturation detection sensor includes a strap and a sensing unit that is arranged on the strap, and sensing unit includes a depth-of-anesthesia sensor and a cerebral oxygen saturation sensor that are arranged on the same plane.
Charm Engineering Co., Ltd.

Active-pulse blood analysis system

An active-pulse blood analysis system has an optical sensor that illuminates a tissue site with multiple wavelengths of optical radiation and outputs sensor signals responsive to the optical radiation after attenuation by pulsatile blood flow within the tissue site. A monitor communicates with the sensor signals and is responsive to arterial pulses within a first bandwidth and active pulses within a second bandwidth so as to generate arterial pulse ratios and active pulse ratios according to the wavelengths.
Masimo Corporation

Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, a processor configured to receive the output signal from the at least one light detector based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area with a ratio factor, eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and then determine a blood glucose level associated with a sample present in the target area based on the calculated attenuance with the processor..
St. Louis Medical Devices, Inc.

Method for noninvasively determining blood glucose concentration

The invention ensures enhanced accuracy of determination of glucose concentration in blood due to reducing of the error of measurements caused by presence of water and melanin in the biomaterial under survey.. .

Non-invasive monitoring of physiological conditions

This document provides methods and materials related to the non-invasive measurement of analytes in blood.. .
Mayo Foundation For Medical Education And Research

Fluid bladder, fluid bladder manufacturing method, blood pressure measurement cuff, and blood pressure monitor

A fluid bladder includes multiple segment bladders that are each formed by folding one sheet in half in a width direction x extending along an artery passing through the measurement site, welding or adhering edge portions on a side opposite to the folding location for folding in half, and welding or adhering edge portions in a lengthwise direction y. The multiple segment bladders are stacked in a width direction orthogonal to the measurement site and integrated, and the folding locations are arranged alternatingly on opposite sides in the width direction..
Omron Healthcare Co., Ltd.

Cutaneous blood flow monitoring device

A method and a device for diagnostic of skin cancer and other mammalian skin tissue pathologies are described. The method relies on determination of pathological changes in tissue vascularization and capillary blood flow.
Veriskin, Inc.

Method and device for ascertaining a blood pressure curve

The invention relates to a method and a device for ascertaining a time-dependent blood pressure curve. Time- and volume-dependent blood flow values are detected in a noninvasive manner in a tissue section with a good blood flow as photoplethysmography values p(t) using a photoplethysmography sensor.
Cis Forschungsinstitut Fuer Mikrosensorik Gmbh

Method and computer system for processing a heart sensor output

The disclosure relates to a method and system for processing a heart sensor output, wherein a blood flow and a simulated aortic blood pressure are derived from a sensed blood pressure using an arterial flow model and values for arterial flow parameters. The simulated aortic blood pressure is matched to a part of the sensed blood pressure in the cardiac cycle by manipulating at least one of the values for the arterial flow parameters of the arterial flow model..

System and methods for improved diabetes data management and use employing wireless connectivity between patients and healthcare providers and repository of diabetes management information

Methods, devices and a system for disease management are provided that employ diagnostic testing devices (e.g., blood glucose meters) and medication delivery devices (e.g., insulin delivery devices) for providing data to a repository in real-time and automatically. Repository data can be analyzed to determine such information as actual test strip use, patient health parameters to outside prescribed ranges, testing and medication delivery compliance, patient profiles or stakeholders to receive promotional items or incentives, and so on.
Becton, Dickinson And Company

Molecular imaging methods for diagnosis and evaluation of ocular and systemic diseases

This invention relates generally to minimally-invasive, in vivo methods of detecting one or more ligands on an intraluminal surface of a blood vessel using microparticles coated with one or more ligand binding partners. More particularly, in certain embodiments, the invention relates to minimally-invasive, in vivo methods of detecting endothelial and leukocyte antigens that are predictive of diabetic retinopathy (dr) and/or other conditions using protein-conjugated microparticles detectable by a non-invasive detection system, for example, a scanning laser ophthalmoscope.
Massachusetts Eye And Ear Infirmary

Method and device for the non-invasive indirect identification of sites of alterations of the blood-retinal barrier

Methods and devices for detecting sites of low optical reflectivity from optical coherence tomography, oct, of the retina are provided. The method includes segmenting retinal layers from oct data, calculating optical reflectivity of each segmented retinal layers from the oct data, and detecting sites of low optical reflectivity from the calculated optical reflectivity of the segmented retinal layers.
Aibili - AssociaÇÃo Para InvestigaÇÃo BiomÉdica E InovaÇÃo Em Luz E Imagem

Connected medical devices

This invention describes how users can capture digital artifacts from any medical device using their mobile device. Some examples of medical devices included, but are not limited to a medical id card, medical id bracelet, electronic medical records, blood pressure machines, blood glucose, scales, inhalers, inr, prescription bottles and trays, pulse oximeter, etc.
Walters Gardens, Inc.

Insulin management

A method of administering insulin includes receiving blood glucose measurements of a patient at a data processing device from a glucometer. Each blood glucose measurement is separated by a time interval and includes a blood glucose time associated with a time of measuring the blood glucose measurement.
Aseko, Inc.

Medical image processing apparatus, medical image processing method, and x-ray ct apparatus

A medical image processing apparatus according to an embodiment includes processing circuitry. The processing circuitry acquires image data including image data of a blood vessel of a subject.
Toshiba Medical Systems Corporation

Device and methods of using device for detection of hyperammonemia

The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflurinated membrane that comprises an ionomer in contact with an alkali buffer in a vessel configured to receive a sample, such as whole blood.
Children's National Medical Center

Aptasensor for detecting female-specific trace of blood and detection apparatus using the same

The present invention relates to an aptasensor for detecting a female-specific trace of blood including an aptamer which is used as a biosensor and emits light as the aptamer is bound to the female-specific trace of blood, and a detection apparatus using the same. The aptasensor for detecting a trace of blood to discriminate genders from the trace of blood at a crime scene has a configuration in which the aptasensor emits light as the aptasensor is binding to the female-specific trace of blood, so that genders of a suspect and a victim is distinguished from each other at the crime scene..
Republic Of Korea (national Forensic Service Director Ministry Of The Interior And Safety)

Diagnostic of heart failure

The invention relates to a method for classifying a patient at risk for heart failure, wherein said method comprises the steps of (i) measuring the concentration of igfbp2 in a sample obtained from said patient and (ii) comparing the concentration of igfbp2 measured in step (i) to a control value derived from the concentration of igfbp2 in samples from patients who are at particular stages of heart failure and/or to a control value derived from the concentration of igfbp2 in blood samples from healthy patients.. .
Centre Hospitalier Universitaire De Toulouse

Mobile sickle cell diagnostic tool

Implementing a mobile device configured to detect sickle cell traits in a blood sample. The device comprises a mobile device with a camera operatively coupled to a microscope lens.

Blood test kit and analyzing method using the same

An object is to provide a blood test kit and a blood analysis method capable of performing a blood test with a small amount of blood at high accuracy by visualizing a volume of blood collection and keeping the volume constant. Provided is a blood test kit for analyzing a concentration of a target component in a blood sample using a normal component homeostatically present in blood, the kit including: a blood collection instrument for collecting the blood sample; a diluent solution for diluting the collected blood sample; and a storing instrument for storing the diluted blood sample, in which the blood collection instrument is a capillary..
Fujifilm Corporation

Method of pooling blood samples

The disclosure provides methods of pooled analysis of samples containing red blood cells, such as whole blood cell samples. The methods are particularly useful for screening whole blood samples collected from many individuals to be used for transfusions and the like.
Gen-probe Incorporated

Methods and compositions for diagnosing or detecting lung cancers

A multi-analyte composition for the diagnosis of lung cancer or lung disease comprises a ligand selected from a nucleic acid sequence, polynucleotide or oligonucleotide capable of specifically complexing with, hybridizing to, or identifying an mrna gene transcript from a mammalian blood sample, and an additional ligand selected from a nucleic acid sequence, polynucleotide or oligonucleotide capable of specifically complexing with, hybridizing to, or identifying an mirna of a gene from a mammalian blood sample. Each ligand and additional ligand binds to a different gene transcript or mirna and the gene transcripts and mirna identified form a characteristic profile of a stage of lung cancer or lung disease.
The Wistar Institute Of Anatomy And Biology

Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells

The present invention relates to methods, kits and compositions for expansion of hematopoietic stem/progenitor cells and providing hematopoietic function to human patients in need thereof. In one aspect, it relates to kits and compositions comprising a notch agonist and an aryl hydrocarbon receptor antagonist.
Novartis Institute For Functional Genomics, Inc., Dba The Genomics Institute Of The Novartis

Cleaning and separating medical waste

The present invention comprises a method of shredding treated medical waste, cleaning it of all traces of biological gunk, and sorting it into separate components for recycling. To clean biological gunk from materials, all materials must be first shredded into small parts to expose the interior.

Use of infrared light absorption for vein finding and patient identification

Disclosed is a medical system for displaying and recording injection sites of patients. After patient identification based on the patient's vein patterns, the system can retrieve and display previous injection sites (e.g., for blood draw or injection) of the patient as overlaid at actual positions of the injection sites.
Becton, Dickinson And Company

Blood purification apparatus

A blood purification apparatus comprising: a blood circuit including an arterial blood circuit and a venous blood circuit and that is capable of extracorporeally circulating blood of a patient from a distal end of the arterial blood circuit to a distal end of the venous blood circuit; a blood purification device provided between the arterial and the venous blood circuit of the blood circuit and that is capable of purifying the blood flowing in the blood circuit; a dialysate introduction line for introducing dialysate into the blood purification device and a dialysate drain line for discharging drain liquid from the blood purification device; a liquid delivery pump provided to the dialysate introduction line and that is capable of causing the dialysate in the dialysate introduction line to flow; a heating device that is capable of heating the dialysate to be introduced from the dialysate introduction line into the blood purification device; a temperature-detecting device that is capable of detecting a temperature of the dialysate heated by the heating device; and a control device that is capable of controlling at least the liquid delivery pump and the heating device, wherein the control device is configured so that, if a dialysate temperature detected by the temperature-detecting device is higher than or equal to a predetermined value, the liquid delivery pump is controlled to cause the dialysate in the heating device to flow to an upstream side or a downstream side with respect to the heating device without allowing the dialysate to be introduced into the blood purification device.. .
Nikkiso Company Limited

Method and preparing a medical solution

The present invention relates to a method for preparing a medical solution from at least one first liquid component and at least one second liquid component, wherein the first component and the second component are conveyed with a respective conveying means to obtain a mixed solution, wherein the conveying means are operated such that a modulation of the concentration of the first and second components takes place and the conductivity or a parameter of the mixed solution correlating with the conductivity is measured at a measurement point, wherein the modulation of the concentrations takes place in a desired state such that no modulation or a specific desired modulation of the measured conductivity or of the parameter correlated with the conductivity occurs. The present invention furthermore relates to an apparatus for preparing a medical solution as well as to a blood treatment device having such an apparatus..
Fresenius Medical Care Deutschland Gmbh

Extracorporeal blood treatment apparatus

An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.. .
Gambro Lundia Ab

Flow estimation using hall-effect sensors

Methods and apparatus for estimating flow rate in a blood circulation assist system employing impeller eccentricity. A method includes magnetically rotating an impeller within a blood flow channel of a blood pump.
Tc1 Llc

Closed disposable multiple sterile blood bag system for fractionating blood with the corresponding method

Disclosed is a multiple bag system for fractionating blood, the system including a fluid collecting bag including at least one outlet port; at least first and second sampling bags, each including at least one inlet port and at least one outlet port; and a fluid transfer unit to transfer fluid from the collecting bag to the sampling bags. The fluid transfer unit includes an acoustic sorter.
Aenitis Technologies

Immobilised biological entities

There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an anti-coagulant entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which anti-coagulant entity is covalently attached to said surface through a linker comprising a thioether.. .
Carmeda Ab

A treating a wound, comprising the step of administering a composition including a substance p

The pharmaceutical composition of the present invention reduces a wound size, generates new blood vessels, shows dermal and epidermal regeneration effects, matures granulation tissues, and synthesizes collagen, and thus may be used for wound healing.. .

Agent containing imidazole dipeptide

An agent uses at least one selected from the group consisting of an imidazole dipeptide and a metabolite thereof as an active ingredient. The present invention also provides an agent for improving a neuropsychologic function, which contains at least one selected from the group consisting of an imidazole dipeptide and a metabolite thereof as an active ingredient.
National Center Of Neurology And Psychiatry

Compositions, kits and methods for treating type ii diabetes mellitus

Disclosed herein are methods for treating type ii diabetes mellitus. In particular, the present invention relates to methods of using an extract of hedychium coronarium koenig and a blood glucose reduction agent, to synergistically reduce the blood glucose level of the subject having type ii diabetes mellitus..
Vitnovo, Inc.

Composition for preventing or treating liver disease comprising pogostemonis herba extract

The present invention relates to a composition having a pogostemonis herba extract which can be effectively used for preventing or treating liver disease. It has been specifically confirmed that the pogostemonis herba extract of the present invention can be used to effectively reduce alt and il-6 levels in blood, tlr 4 protein expression level within a liver.
Research & Business Foundation Sungkyunkwan University

Method of treating or inhibiting the development of brain inflammation and sepsis

A leukotriene c4 and d4 antagonist is used to treat or inhibit brain inflammation and sepsis by acting to inhibit increased capillary permeability and white blood cell extravasation. Potential candidate compounds can be screened in a non-human mammal before or after administration of an inflammation inducing agent into the subarachnoid space by determining their ability to inhibit increased capillary permeability and white blood cell extravasation..
Inflammation Research Center Company Ltd.

Multifunction joint brace

A multifunction joint brace that includes a belt that is wrapped about a user's waist, ankle, neck, wrist, hand or elbow and positions three electrically powered heating elements that are activated to apply low, medium, and high levels of heat to areas of muscle and tissue to relieve pain temporarily and increase blood flow to the affected area. The brace is in the central region.

Apparatus and treating eye diseases

A method, device, or system for treating eye disorders or conditions, comprising restoring or increasing blood flow or blood flow rate in an artery that supplies blood to or in the eye, thereby increasing the amount of oxygen that reaches the eye or a portion thereof.. .
Ocudyne Llc

Device and methods for self-centering a guide catheter

This document provides devices and methods for the treatment of heart conditions such as valvular stenosis. For example, this document provides devices and methods by which a guide catheter can align itself with a blood flow stream to thereby help direct a guidewire or other elongate device transmitted from the guide catheter through an orifice of a heart valve..
Mayo Foundation For Medical Education And Research

Atrial appendage blood filtration systems

Instrumentation for percutaneous delivery of blood filtration devices to atrial appendages includes a curved access sheath and a delivery tube. A compressed filter device attached to a tether wire is loaded in the delivery tube.
Atritech, Inc.

Mouth piece for cooling of oral tissue of a patient during chemotherapy treatment

The invention is directed to a mouth piece for cooling of oral tissue of a patient during chemotherapy treatment. The mouth piece includes a cooling medium contained within the top element and the bottom element and able to retain a cooling environment within the mouth sufficient to reduce capillary blood flow to the patient's mouth.

Radio frequency electro-thrombectomy device

A device is designed to remove blockages in a lumen such as a thrombus, blood clot, or embolus. The device comprises a manipulating wire and a structure that can conduct electrical current to a lumen blockage.
The Hong Kong University Of Science And Technology

Method and system for modeling blood flow with boundary conditions for optimized diagnostic performance

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data.
Heartflow, Inc.

System and biometric identification using sleep physiology

The claimed invention comprises software methods for user continuity and physiological state change assessments through generating biometric profiles of individuals and/or groups of individuals by using physiological input together with biomathematical modeling and machine learning techniques. Intra-individual variation in physiological variables including, but not limited to: heart rate, heart rate variability, pulse waveform and its derivatives, blood pressure, breathing rate, cardiopulmonary coupling, actigraphy and circadian rhythms characteristics, are exploited..
Lifeq Global Limited

Computer-accessible medium for determining arterial input function

An exemplary system, method and computer-accessible medium for determining an arterial input function (aif) of a mammal(s) can be provided, which can include, for example, receiving information related to a global circulatory system of the mammal(s), and determining the aif based on the information by modeling a blood flow in the global circulatory system of the mammal(s) in terms of an input response function(s). The input response function(s) can include a delayed input response function(s).
Albert-ludwigs-universifat Freiburg

Blood pressure meter

A blood pressure meter includes a pump and a first fluid path provided inside a main body. The first fluid path feeds a fluid from the pump to a fluid bladder or discharges the fluid from the fluid bladder.
Omron Healthcare Co., Ltd.

Apparatus and measuring biologic parameters

Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body.
Geelux Holdings, Ltd.

Short-wave infrared super-continuum lasers for early detection of dental caries

A wearable device includes a measurement device having light emitting diodes (leds) measuring a physiological parameter. The measurement device modulates the leds to generate an optical beam having a near-infrared wavelength between 700-2500 nanometers.
Omni Medsci, Inc.

Measurement system

A measurement system may comprise a sensor wire and a transceiver unit. The sensor wire may comprise an insertable portion configured to be inserted in a blood vessel of a patient's body and two sensors disposed within the insertable portion at a distal end of the sensor wire.
St. Jude Medical Coordination Center Bvba

Method and system for classifying optic nerve head

Provided are a method and system for identifying and classifying the owner, age and health of an optic nerve head and its vasculature based on analysis of vector relationships of blood vessels and the neuroretinal rim within an image of the optic nerve head to each other.. .
Delphinium Clinic Ltd.

Blood-vessel recognition system

Unnecessary emission of strong laser light is automatically prevented. Provided is a blood-vessel recognition system including: a laser-light source; a blood-vessel recognition probe that has a probe body that is inserted into a body and a laser-light emitting unit that is provided on the probe body and that emits laser light supplied from the laser-light source; an in-use-state determining unit that determines whether the blood-vessel recognition probe is in an in-use state in which the laser light emitted from the laser-light emitting unit is radiated onto living tissue in the body; and a control unit that controls the laser-light source on the basis of a determination result obtained by the in-use-state determining unit, such that the intensity of the laser light is reduced when the blood-vessel recognition probe is not in the in-use state, compared with when the blood-vessel recognition probe is in the in-use state..
Olympus Corporation

Systems and methods for monitoring of blood lactate and targeting of blood lactate via nutritional support

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“bes”) of a patient, are disclosed. The bes provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient.
Run Them Sweet Llc

Platelet storage methods and compositions for same

Disclosed are compositions and methods for slowing, preventing, or reversing platelet damage, particularly as may occur during blood banking or during refrigeration of platelets. The composition may include one or more of a rac inhibitor, a cdc42 inhibitor, a rhoa inhibitor, or a combination thereof.
Children's Hospital Medical Center

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Laboratoires Invalv

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Stemlab, S.a.

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Location-based wireless diabetes management systems, methods and apparatus

Embodiments provide systems, methods and apparatus for diabetes management using location-based reminders. Embodiments include requesting a user select a diabetes management related task to be reminded to perform; requesting the user select a location at which the user is to be reminded to perform the selected diabetes management related task; monitoring the user's location; detecting the user has entered the selected location; triggering the reminder in response to detecting the user has entered the selected location; and presenting the reminder to the user.
Ascensia Diabetes Care Holdings Ag

System and simulating arterial pressure pulses

A method and apparatus to simulate arterial blood pressure pulses to train clinicians in the use of oscillometric blood pressure monitors is described. The apparatus comprises a bladder or blood pressure cuff placed in a rigid enclosure with a known volume.
Dynasthetics, Llc

Basal insulin management

An improved basal insulin management system and an improved user interface for use therewith are provided. User interfaces are provided that dynamically display basal rate information and corresponding time segment information for a basal insulin program in a graphical format.
Insulet Corporation

Blood test apparatus

A first rack of a first color and a second rack of a second color respectively hold blood collecting tubes. After a test is finished, the first and second racks are disposed at a carrying-out section.
Nihon Kohden Corporation

Diagnostic detection device and detecting human chorionic gonadotropin or derivative in urine, blood, saliva, or other body fluid

A diagnostic detection device and method with higher sensitivity to detect human chorionic gonadotropin (hcg) or derivative in urine, blood, saliva, or other body fluid for pregnancy test, detection of hcg doping in sports, or diagnosis of other diseases and conditions related to hcg abnormalities is disclosed. It harnesses the power of material capable of transporting specimen by capillary action, sandwich complex technique with a mobile anti-hcg antibody conjugated with a specific marker, hcg or derivative, and an immobile anti-hcg antibody, and a highly sensitive detection system for the marker or change of conditions of the marker.

Method for identifying marker proteins for the diagnosis and risk stratification of blood coagulation disorders

The invention relates to a method for identifying marker proteins for the purpose of diagnosis and risk stratification of blood coagulation disorders.. .
Leibniz-institut FÜr Analytische Wissenschaften - Isas - E.v.

Liquid biopsy detection of leukemia using closed-loop microfluidics

This invention describes a one-step technique for the simultaneous label-free detection and concentration of blast cells from a blood sample. Enrichment of blast cells is achieved using a closed loop microfluidics system, allowing continuous removal of waste and non-target cells to generate concentrated samples of high purity without the need for specific targeting of proteins by antibodies.
Massachusetts Institute Of Technology

Portable clinical analysis system for immunometric measurement

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof..
Abbott Point Of Care Inc.

Device for whole blood separation

Separation of the cellular components of whole blood, or other biological fluid, from plasma or serum can be achieved for assay analysis. A device for facilitating separation can include, for example, a capillary tube that accurately draws target blood volume, a pad that chemically interacts with red-blood cells, such that the red blood cells become chemically and/or physically trapped within pad material, a mechanism for plasma recovery from the pad upon diffusion or active mixing, and a dropper tip that facilitates dispensing the mixture onto a test device.
Quidel Corporation

Method and determining markers of health by analysis of blood

Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time.
Nueon Inc.

Serum- or plasma-separating composition, blood-test container, and stabilizing serum- or plasma-separating composition

There is provided a serum- or plasma-separating composition less likely to cause separation between a liquid organic compound and a thixotropy imparting component and capable of maintaining a homogeneous blended state for a prolonged period. The serum- or plasma-separating composition comprises a liquid organic compound, a thixotropy imparting component, and a thermoplastic elastomer..
Sekisui Medical Co., Ltd.

Biosensors for detecting cholesterol and oxldl in blood sample

The present invention provides biosensors for detecting cholesterol and oxldl in blood sample. The present invention relates to a paper-based colorimetric biosensor and an electrochemical biosensor each for detecting cholesterol and oxldl in blood sample.

Basophil analysis system and method

Provided herein are systems and methods for analyzing blood samples, and more specifically for performing a basophil analysis. In one embodiment, the systems and methods include: (a) staining a blood sample with an exclusive cell membrane permeable fluorescent dye; and then (b) using measurements of light scatter and fluorescence emission to distinguish basophils from other wbc sub-populations.
Abbott Laboratories

Method for hematology analysis

A method whereby one or more fluorescent dyes are used to bind and stain nucleic acids in certain blood cells, such as, for example, white blood cells, nucleated red blood cells, and reticulocytes, and to induce fluorescent emissions upon excitation of photons from a given source of light, such as, for example, a laser, at an appropriate wavelength. More particularly, this invention provides a method whereby a fluorescent trigger is used in a data collection step for collecting events that emit strong fluorescence, in order to separate white blood cells and nucleated red blood cells from red blood cells and platelets without the need for using a lysing agent..
Abbott Laboratories

Method for measuring coagulation of blood samples using viscoelastic tests (vet)

This disclosure provides a method for measuring coagulation of blood or plasma samples using viscoelastic tests (vet) wherein the measuring is performed in the presence of immobilised endothelial cells.. .
Ca Casyso Gmbh

Blood biomarkers for appendicitis and diagnostics methods using biomarkers

The invention relates to methods and kits for diagnosing and/or treating appendicitis in a subject, comprising obtaining a biological sample from said subject; detecting rna expression levels of at least three or more biomarkers in the biological sample and comparing the expression levels of said at least three or more biomarkers to a control sample wherein an increase or decrease in the level of expression of said at least three or more biomarkers as compared to the control sample is indicative of appendicitis.. .
The George Washington University A Congressionally Chartered Not-for-profit Corporation

Method for determining p1/p2 blood type and detection kit thereof

The present invention provides a method for determining p1/p2 blood type, including steps of providing a biological sample of a subject, detecting a genotype for single nucleotide polymorphism rs2143918 or rs5751348 in a4galt gene of the biological sample and determining a phenotype of the subject based on the genotype. Further, the present invention also provides a kit for determining p1/p2 blood type, including a primer pair for detecting a genotype for single nucleotide polymorphisms rs2143918 or rs5751348 in a4galt gene of a nucleic acid sample of a subject..
National Taiwan University

System for improving diabetes testing and reducing counterfeiting

A diabetes test system for measuring blood glucose levels is provided, which includes a glucose meter, at least one diabetic test strip, and a container or pouch for storing the diabetes test strips and protecting them during transport. Methods of packaging diabetes test strips are also provided.

Immobilized plasminogenase composition, preparation process, use and device comprising such a composition

Disclosed is an enzymatic composition including:—at least one enzyme, termed plasminogenase, for converting, into plasmin, plasminogen from a blood plasma medium including plasminogen;—a solid support that is insoluble in aqueous solution, the solid support having dimensions suitable for being able to be retained on a filter having a cut-off threshold of less than or equal to 0.22 μm. The plasminogenase is bound to the solid support and remains bound to this support on contact with a blood plasma medium.
Arcadophta

Compositions and methods for reprogramming adult cells through the stemness of a platelet rich fraction of blood containing platelet-like cells in humans

The described invention provides a method of functionally reprogramming adult cells to an immature cell type that expresses one or more embryonic biomarkers with a platelet rich fraction comprising platelet-like cells from umbilical cord blood or peripheral blood, and expanding the immature cell type in vitro under culture conditions to generate an insulin-producing cell population that expresses human beta-cell specific transcription factors and is functionally equivalent to human pancreatic beta-cells. It further provides a pharmaceutical composition comprising a cell product containing a therapeutic amount of an insulin-producing cell population, wherein the insulin-producing cell population expresses human beta-cell specific transcription factors and is functionally equivalent to human pancreatic beta-cells, and a method for treating a recipient subject suffering from a disease characterized by hyperglycemia with the pharmaceutical composition..
Hackensack University Medical Center

Use of macrophage inflammatory protein-1beta (mip-1beta) inhibitor to protect pancreas and prevent blood sugar from rising

The present invention relates to a use of a macrophage inflammatory protein-1β (mip-1β) inhibitor to protect the pancreas and prevent blood sugar from rising. The present invention relates to a use of a macrophage inflammatory protein-1β (mip-1β) inhibitor to protect the pancreas, and to prevent blood sugar from rising in a diabetic subject..
National Yang-ming University

Minimally-invasive collection system for collecting biological samples for quantifying heavy metals, other toxicants, pathogens, and biomarkers

Disclosed are devices, kits, compositions, and methods for collecting, transporting, and detecting toxicants, pathogens, and biomarkers in a biological sample. The devices, kits, compositions and methods may be utilized to collect and transport dried blood samples from a skin prick and detect toxicants, pathogens, and biomarkers in the dried blood samples..
Northwestern University

Systems and methods for platelet concentration with a spinning membrane separator

A method for automated processing of a blood product, the method comprising providing a reusable separation apparatus controlled by a microprocessing unit, said apparatus configurable with settings and configured to associate with a disposable circuit comprising a separator and in communication with a source blood product having a first concentration and first volume. The apparatus and disposable circuit are configured to flow the source blood product into an inlet of the separator and separate supernatant of the source blood product from a first outlet of the separator into a filtrate container.
Fenwal, Inc.

Selective cell destruction through electromagnetic resonance

Methods and devices for selectively destroying a cell or population of cells in cell cultures, fluids, blood or in the tissue or organs of a subject using electromagnetic resonance by targeting one, or more, specific protein(s) and/or nucleic acid(s) within the cell or cell population are described.. .
The Charles Stark Draper Laboratory, Inc.

Method and controlling spinal cord stimulation to treat hypertension

An example of a system for modulating blood pressure may include a blood pressure monitoring circuit, a blood pressure modulation device, and a control circuit. The blood pressure monitoring circuit may be configured to sense signals and generate one or more blood pressure parameters indicative of the blood pressure and/or a vascular resistance and one or more activity parameters indicative of an activity level and/or a postural change using the sensed signals.
Boston Scientific Neuromodulation Corporation

Systems and methods for detecting and visualizing blood vessels

The present invention relates to systems and methods for detecting and visualizing blood vessels. One of the implementations of a blood vessel detecting and visualizing system comprises a sensing device, a processing circuitry, and a visualization device.

Filtering needle provided with rotationally cuttable and removable intake tube and filtering syringe

Provided are a filtering needle, which has a rotationally cuttable and removable intake tube coupled thereto, and a filtering syringe using same. The present invention relates to a filtering needle, which overcomes the shortcoming of a conventional filtering syringe in which while the conventional filtering syringe performs a filtering intake and the discharge of an injectable solution using one needle, glass fragments, which do not flow deeply into the inner channel of a filter but remain between the needle and the filter, are introduced into a human body via the needle during an injection, the filtering needle being characterized in that while an intake part (20) provided with an intake tube, which is slightly larger than the needle, and capable of being spirally cut is placed over a needle part (10) and then rotationally removed therefrom, a connecting tube (24) inside the intake part and embedded in an inlet (16) comes out and simultaneously interlocks with a rotary plate plug (14) of the needle part, thereby closing the inlet (16) connected to the filter (15) and opening an outlet (17) connected to the needle (11).

Aspirator syringe with blood detector

An aspirator syringe comprising a blood-detecting spectrometer. The syringe may accommodate a standard drug cartridge and may provide manual or automatic movement of a plunger for aspiration and injection.
University Of Dammam

Blood gas exchanger with restriction element or elements to reduce gas exchange

A gas exchanger with a restriction element or elements to reduce gas exchange as desired to avoid hypo-capnia and hyper-oxygenation in small patients. The gas exchanger includes a gas exchanger housing with an outer wall and a core which defines an inner wall and having a blood inlet for receiving a blood supply and a blood outlet.
Sorin Group Italia S.r.l.

Calibration flowmeters in blood dialysis system

Provided is a calibration method for flowmeters in a blood dialysis system, whereby highly accurate calibration can be performed even by omitting a reference flowmeter not directly relating to dialysis therapy. This calibration method comprises: while preventing outflow into a blood channel in a blood purifier, supplying a liquid to a channel, said channel passing through an inflow flowmeter and an outflow flowmeter; and then calibrating the inflow flowmeter and the outflow flowmeter correction whereby, at the time of liquid supply, a value measured by the outflow flowmeter is equalized to a value measured by inflow flowmeter..
Nikkiso Co., Ltd.

Blood purification apparatus

A blood purification apparatus in which the error in the amount of discharge from a blood pump that is caused by the change in the suction pressure of the blood pump is reduced. A blood purification apparatus includes a blood circuit through which blood of a patient is extracorporeally circulated; a dialyzer connected to proximal ends of an arterial blood circuit and a venous blood circuit and that purifies the blood extracorporeally circulating through the blood circuit; a squeezable tube connected to the arterial blood circuit; a blood pump allowing liquid in the squeezable tube to flow by squeezing the squeezable tube in a lengthwise direction while compressing the squeezable tube in a radial direction; and a pressure-detecting device attached to a predetermined position of the arterial blood circuit that is nearer to a distal end than a position where the blood pump is provided, the pressure-detecting device being capable of detecting a suction pressure of the blood pump..
Nikkiso Company Limited

Blood pump for the invasive application within a body of a patient

The invention relates to a blood pump for the invasive application within a body of a patient comprising a rotor (43, 27) which is drivable about an axis of rotation and is radially compressible or expandable and which has a hub (18, 28) and at least one impeller blade (14, 15, 16, 17, 29, 30) fastened thereto, as well as comprising a housing (19, 19′) which is compressible or expandable in the radial direction by an axial stretching or axial compression. The object of making both the rotor and the housing expandable and compressible in as simple a manner as possible is achieved in accordance with the invention in that a control body (21) is provided which passes through the hub (18) in the longitudinal direction, which is freely axially displaceable relative to the hub and which is coupled to the housing on the distal side of the rotor such that it exerts pulling and/or compression forces on the housing by a movement in the longitudinal direction with respect to the housing..
Ecp Entwicklungsgesellschaft Mbh

Heart assist system and methods

A system for drawing blood from a heart of a patient, includes a blood pump, an outflow cannula and a flexible cannula assembly. The cannula assembly further includes a flexible cannula body including a proximal end, a distal end, an inner wall defining a lumen, and an outer wall.
Circulite, Inc.

Xbp1, cd138, and cs1 peptides, pharmaceutical compositions that include the peptides, and methods of using such peptides and compositions

The disclosure features, inter alia, immunogenic xbp1-, cd138-, and cs1-derived peptides (and pharmaceutical compositions thereof). The peptides can be used in a variety of methods such as methods for inducing an immune response, methods for producing an antibody, and methods for treating a cancer (e.g., breast cancer, colon cancer, pancreatic cancer, a blood cancer, e.g., leukemia or a plasma cell disorder such as multiple myeloma or waldenstrom's macroglobulinemia).
Dana-farber Cancer Institute, Inc.

Pharmaceutical composition for preventing and treating eye diseases, containing, as active ingredient, fusion protein in which tissue-penetrating peptide and anti-vascular endothelial growth factor preparation are fused

The present invention relates to a pharmaceutical composition for preventing and treating eye diseases, comprising, as an active ingredient, a fusion protein in which a tissue-penetrating peptide and an anti-vascular endothelial growth factor (anti-vegf) preparation are fused. More particularly, the present invention relates to: a pharmaceutical composition for preventing and treating eye diseases, comprising, as an active ingredient, a fusion protein in which a tissue-penetrating peptide and an anti-vegf preparation are fused; a method for prepraring an anti-vegf preparation, which overcomes resistance and has an improved efficacy, the method comprising the steps of transforming a host cell with a recombinant vector comprising a nucleic acid sequence encoding a fusion protein in which a tissue-penetrating peptide and an anti-vegf preparation are fused, culturing the cell, and recovering a fusion protein from the cell; a method for treating eye diseases, comprising administering an effective dose of the fusion protein according to the present invention to a subject in need thereof; and use of the fusion protein according to the present invention for preparing an agent for treating eye diseases.
Ildong Pharm Co., Ltd.

Method of treating low blood pressure

A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of angiotensin ii, or ang ii, to the patient..
The George Washington University A Congressionally Chartered Not-for-profit Corporation

Method for enhancing insulin like growth factor 1 receptor expression of mesenchymal stem cell, isolating mesenchymal stem cell, and use of mesenchymal stem cell

A method for enhancing an insulin like growth factor 1 receptor expression of a mesenchymal stem cell is provided. The method includes culturing a plurality of mesenchymal stem cells expressing insulin-like growth factor 1 receptors in media containing human cord blood serum to enhance the insulin like growth factor 1 receptor expression of the mesenchymal stem cells..
China Medical University

Kai1 protein controlling cell cycle of hematopoietic stem cell, and use thereof

Provided is a kai1 protein controlling the cell cycle of a hematopoietic stem cell and a use thereof, and more specifically, a composition including a kai1(cd82) polypeptide or a gene encoding the same for controlling the cell cycle of a hematopoietic stem cell, or a pharmaceutical composition for preventing or treating blood tumors. Further provided, kai1(cd82) is expressed only in a hematopoietic stem cell (lt-hsc) which is the uppermost stem cell in the hierarchy of the hematopoietic stem cell, can obtain an lt-hsc with high purity using the kai1, and thus can inhibit various side effects of hematopoietic stem cell transplantation by transplanting only an lt-hsc with high purity.
Seoul National University R & Db Foundation

Process for removing growth factors from platelets

In vitro and in vivo application of sub-atmospheric, negative pressure on growth factor starting material, such as whole blood, extracts growth factors from the platelet granules of the growth factor starting material in a non-destructive medium without activating the clotting process. The extracted growth factors are released into a growth factor composition containing blood plasma, extracellular fluid or interstitial fluid depending upon the type and location of the growth factor starting material.
Pgfx Patent Holdings, Llc

Methods for the storage of whole blood, and compositions thereof

Methods and compositions for improved clinical outcomes for trauma patients receiving whole blood transfusion. Methods and compositions for improved clinical outcomes for blood transfusions for cancer patients are also provided..
New Health Sciences, Inc.

Methods of producing enriched populations of tumor reactive t cells from peripheral blood

Methods of obtaining a cell population enriched for tumor-reactive t cells, the method comprising: (a) obtaining a bulk population of peripheral blood mononuclear cells (pbmcs) from a sample of peripheral blood; (b) specifically selecting cd8+ t cells that also express pd-1 and/or tim-3 from the bulk population; and (c) separating the cells selected in (b) from unselected cells to obtain a cell population enriched for tumor-reactive t cells are disclosed. Related methods of administering a cell population enriched for tumor-reactive t cells to a mammal, methods of obtaining a pharmaceutical composition comprising a cell population enriched for tumor-reactive t cells, and isolated or purified cell populations are also disclosed..
The United States Of America,as Represented By The The Secretary, Department Of Health And Human Ser

Novel dietary supplements

Compositions and methods for improving nitric oxide levels in a subject, comprising administering to a subject, a composition comprising dietary nitrate derived from potassium nitrate, beet root (whole plant, powder, plant extract), and/or nitrate-rich leafy green portions (whole plant, powder, plant extract) that improve functional nitric oxide levels in subjects as shown by increasing salivary bioconversion of nitrate to nitrite, a necessary a required step for nitric oxide mediated health benefits. The disclosed novel compositions improve cardiac health, lowers blood pressure, intraocular pressure, and ldl and restores nitric oxide mediated cardiovascular benefits, including but not limited, restoring endothelium function and improving flow mediated dilation..
Berkeley Nox Limited

Inhalation of nitric oxide for treating respiratory diseases

A method of treating a human subject which is effected by intermittent inhalation of gaseous nitric oxide at a concentration of at least 160 ppm is disclosed. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder that can be treated via the respiratory tract.
Advanced Inhalation Therapies (ait), Ltd.

Impact of electrolytes on tumors and various diseases

I am filing 8 claims, 7 of them are based on the impact received from electrolytes. At the moment i feel that this is a gray area with heavy regulations which are preventing people from receiving enormous benefits from i.v.

Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor

The invention relates to a pharmaceutical combination which comprises (a) a phosphoinositide 3-kinase inhibitor compound of formula (i) and (b) a mtor inhibitor for the treatment of a target of rapamycin (mtor) kinase dependent disease, especially a cancer disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human.. .
Novartis Ag

Renal neuromodulation methods and systems for treatment of hyperaldosteronism

Methods for treating hyperaldosteronism with therapeutic renal neuromodulation and associated systems and methods are disclosed herein. One aspect of the present technology, for example, is directed to methods that at least partially inhibit sympathetic neural activity in renal nerves proximate a renal blood vessel of a human patient.
Medtronic Ardian Luxembourg S.a.r.l.

System and device for engulfing thrombi

A system for removing a thrombus from a blood vessel includes a stent retriever, a catheter configured to receive the stent retriever in a collapsed configuration, wherein the stent retriever is movable relative to the catheter, a sheath having a tubular body and defining a distal opening and a proximal opening, and a wire coupled to the stent retriever for positioning the stent retriever. The wire extends through the proximal opening and the distal opening of the sheath.

Shaped delivery sheath and methods

Embodiments relate to delivery systems for accessing a blood vessel. The delivery systems include a shaped accessory sheath having a default shape that may be temporarily altered to facilitate insertion through a patient's blood vessel and returned to the default shape after insertion to facilitate a medical procedure.
W. L. Gore & Associates, Inc.

Ultrasound doppler monitoring system

The disclosure is directed to a novel doppler ultrasound system and method for monitoring physiological parameters, such as blood flow and heart rate in which signal clarity and accuracy is improved by actively filtering out system, environmental and background signal noise.. .
Huntleigh Technology Limited

Imaging wire positioning

The imaging system includes a wire, a second signal transmission unit and a computer system. At least one first signal transmission unit is disposed on the wire which is configured to enter a blood vessel in a human body.
Metal Industries Research & Development Centre

Contactless blood pressure monitoring of a patient

Contactless blood pressure monitoring, includes: illuminating a blood vessel of a patient with infrared (‘ir’) light; receiving, by an ir camera through a polarizing filter, ir light reflected by the patient; capturing at a time based on a heartrate of the patient, a first ir image of the blood vessel of the patient when the blood vessel is distended; determining, from the first image, a maximum diameter of the blood vessel; capturing at a time based on the heartrate of the patient, a second ir image of the blood vessel of the patient when the blood vessel is contracted; determining, from the second ir image, a minimum diameter of the blood vessel; and calculating blood pressure of the patient in dependence upon the maximum and minimum diameters of the blood vessel.. .
International Business Machines Corporation

Method and systems for correcting for arterial compliance in a blood pressure assessment

A system for monitoring blood pressure of a subject includes a primary system for determining a first blood pressure and a corrective system. The corrective system includes a cuff configured to be operated in an inflation phase and a deflation phase, a sensor array which produces inflation and deflation phase output signals, and a processor.
Welch Allyn

Contactless blood pressure monitoring of a patient

Contactless blood pressure monitoring, includes: illuminating a blood vessel of a patient with infrared (‘ir’) light; receiving, by an ir camera through a polarizing filter, ir light reflected by the patient; capturing at a time based on a heartrate of the patient, a first ir image of the blood vessel of the patient when the blood vessel is distended; determining, from the first image, a maximum diameter of the blood vessel; capturing at a time based on the heartrate of the patient, a second ir image of the blood vessel of the patient when the blood vessel is contracted; determining, from the second ir image, a minimum diameter of the blood vessel; and calculating blood pressure of the patient in dependence upon the maximum and minimum diameters of the blood vessel.. .
International Business Machines Corporation

Determining an early warning score based on wearable device measurements

A method and systems for determining an early warning score for a health status of a patient are provided. An example method includes acquiring, during a predetermined time period via sensors integrated into a wearable device worn on a wrist of the patient, initial values of medical parameters of patient.
Chronisense Medical Ltd.

Wearable device for healthcare and method thereof

The present invention relates to a wearable device for healthcare and method for using the device. More specifically, the wearable device is worn on a finger for measuring the health data of the user, selected from one or more of heart rate, blood oxygen saturation, heart rate variability.
Belun Technology Company Limited

Scanned laser vein contrast enhancer using a retro collective mirror

The present invention is a miniature vein enhancer that includes a miniature projection head. The miniature projection head may be operated in one of three modes, afm, dbm and rtm.
Accuvein, Inc.

Artery locating device and automated sampling device for arterial blood gas measurement

Method and device for using energy transduction for novel use in locating an underlying artery, particularly a more superficial artery like the radial artery. The method includes placing or scanning the device containing an electrical system, which comprises of an arterial pressure or motion transducer converted to visible light energy on the overlying skin in the region of the vessel.

Portable phlebotomy kit

Described herein are various systems, methods, apparatuses, and kits for phlebotomy. In certain embodiments, the phlebotomy kit or system includes a blood collection tube, a needle assembly, a holder for the blood collection tube, a bandage, a tourniquet, a wipe, and an absorbent pad.
Orig3n, Inc.

Tissue profile wellness monitor

A tissue profile wellness monitor measures a physiological parameter, generates a tissue profile, defines limits and indicates when the tissue profile exceeds the defined limits. The physiological parameter is responsive to multiple wavelengths of optical radiation after attenuation by constituents of pulsatile blood flowing within a tissue site.
Masimo Corporation

Living body monitoring system, portable electronic apparatus, living body monitoring program, computer readable recording medium, living body monitoring method, display device and display method

A living body monitoring system includes an output unit that outputs information regarding a load applied on a user's body on the basis of information regarding a change in an altitude of a point where the user is located and information regarding a change in a blood oxygen amount of the user.. .
Seiko Epson Corporation

Blood pressure measurement device with a mems pump and control the same

This invention discloses a blood pressure measurement device including a cuff having a bladder wrap around an object to be measured, a mems pump for inflating the bladder with air, a pressure sensor for monitoring the pressure in the bladder, and a microcontroller for controlling the pressure sensor to continuously receive pressure signals during the process of inflating the bladder, converting the pressure signals into blood pressure values, and controlling a drive voltage level of the mems pump to maintain an air inflation speed of the mems pump in a predetermined inflation speed range. The invention further discloses a method for controlling a fixed frequency change of the blood pressure measurement device..
Microlife Corporation

Blood pressure determinations

Methods and devices for blood pressure monitoring may include receiving one or more sensor measurements from the at least one sensor. The methods and devices may further include determining at least one of a first blood pressure indication using a first regression representation based on the one or more sensor measurements, a second blood pressure indication using a second regression representation based on the one or more sensor measurements, or a third blood pressure indication using a third regression representation based on the one or more sensor measurements.
Microsoft Technology Licensing, Llc

Retrieval float

The disclosed device is a retrieval float for use during spear fishing and diving. The retrieval float allows a diver to send marine organisms that have been caught by various underwater methods to the surface.
Toothless, Inc.

Iduronate-2-sulfatase and use thereof

Provided is a modified iduronate-2-sulfatase (ids) gene constructed by inserting the nucleotide of seq id no: 2 into a wild-type ids gene. In addition to being negatively charged, the improved ids enzyme encoded by the modified gene exhibits a sufficient retention time in blood to target the bone, so that it is more effective for treating hunter syndrome..
Koppe Royalty B.v.

Masimo Corporation

. .

Method and device for audio recording

An acquisition system includes a processor, one or more sensors operatively coupled to the processor where the one or more sensors acquire at the ear, on the ear or within an ear canal, one or more of acceleration, blood oxygen saturation, blood pressure or heart-rate, and the one or more sensors configured to monitor a biological state or a physical motion or both for an event. The event can be a detection of a discrepancy when compared with a set of reference data by the one or more sensors or the biological state or the event can be one of a detection of an abrupt movement of a headset operatively coupled to the processor, a change in location of an earpiece operatively coupled the processor, a touching of the headset, a recognizing of a voice command, a starting or ending of a phone call, or a scheduled time..
Staton Techiya Llc

Blood glucose management device for calculating bolus insulin

A method of operating a glucose management device. The glucose management device includes one or more processing components, a housing, a user interface including a display and a user-input mechanism, and a memory.
Ascensia Diabetes Care Holdings Ag

Family genetic history storage system for storing dna information on an identification certificate

A family genetic history storage system for storing dna information on an identification certificate includes a selected area for attaching an identification indicators with at least one dna blood sample storage area. It includes a means for storing the blood sample for future use and analysis while protecting it from environmental contamination.

Using an nfc enabled mobile device to manage digital medical artifacts

This invention describes how users can use an nfc enabled mobile device to manage medical digital artifacts such as a medical id, basic patient information, patient contact information, emergency contact information, primary care physician information, health insurance information including co-pay and deductibles, prescriptions, office visit summary, appointment cards, electronic medical records (emr), lab results, blood type, organ/donor status, vital signs, diagnostic data, immunization records, payments and transaction history, pictures, etc using an nfc enabled device, users can also pay for prescriptions as well as pay for medical services.. .
Blaze Mobile

Predictive test for aggressiveness or indolence of prostate cancer from mass spectrometry of blood-based sample

A programmed computer functioning as a classifier operates on mass spectral data obtained from a blood-based patient sample to predict indolence or aggressiveness of prostate cancer. Methods of generating the classifier and conducting a test on a blood-based sample from a prostate cancer patient using the classifier are described..
Biodesix, Inc.

Representative waveform providing apparatus and method

A representative waveform providing apparatus and method, a blood pressure estimation apparatus, and a wearable device are provided. The representative waveform providing apparatus may include a signal obtainer configured to obtain a periodic signal and a processor configured to determine a representative waveform of the periodic signal by using a dynamic time warping algorithm..
Samsung Electronics Co., Ltd.

Blood test kit and blood analysis method

An object of the present invention is to provide a blood test kit and a blood analysis method capable of performing a blood test with a small amount of blood at high accuracy by visualizing a volume of blood collection and keeping the volume constant. According to the present invention, a blood test kit including a diluent solution for diluting components of a blood sample; and at least one transparent container for storing the components of the blood sample and the diluent solution, in which at least one constituent component included in the blood test kit is marked with a graduation for measuring the components of the blood sample and a liquid volume of the diluent solution, is provided..
Fujifilm Corporation

Blood analysis method and blood test kit

An object of the present invention is to provide a blood analysis method in which a high level of repeatability and reproducibility is achieved with respect to measurement values in a blood sample, and a blood test kit which is used for the blood analysis method. According to the present invention, a blood analysis method including a step of diluting a collected blood sample with a diluent solution; a step of quantitatively determining sodium ions in the diluent solution of the blood sample by using a solution containing β-galactosidase and at least one substrate which is convertible by β-galactosidase so as to determine a dilution factor from a normal value of serum and blood plasm sodium ions which are homeostatically present in the blood and the quantitative value of sodium ions; and a step of analyzing a concentration of a target component to be measured in the blood sample from the determined dilution factor and a measurement value of a concentration of the target component to be measured in the blood sample, in which the diluent solution is a diluent solution which does not contain sodium ions, is provided..
Fujifilm Corporation

Methods of treating with tumor membrane vesicle-based immunotherapy and predicting therapeutic response thereto

Disclosed herein is a method for treating a subject having, or at risk of having, a triple negative breast cancer, comprising administering to the subject a therapeutically effective amount of an immunotherapeutic agent and a tumor membrane vesicle (tmv), wherein the tmv comprises a lipid membrane, and a b7-1 and/or il-12 molecule anchored to the lipid membrane. Also disclosed is method for predicting the likelihood a human subject having a cancer will respond therapeutically to a tmv immunotherapy, wherein the method comprises obtaining a blood or serum sample from the subject; measuring the amount of a set of biomarkers in the sample, wherein the biomarkers include at least ifn-gamma, tnf-alpha, and il-2, and wherein an increase in the level of the biomarkers as compared to a control indicates an increased likelihood the subject will respond therapeutically to the tmv immunotherapy..
Emory University

Biomarker detection and self-separation of serum during capillary flow

Molecularly imprinted polymers (mips) are utilized to detect diseases and minimize false negative/positive scenarios. Mips are implemented on a nano-electric circuit in a biochip where interactions of mips and an antigen/antibody (ag/ab) are detected, and disease specific biomarkers diagnosed.
New Jersey Institute Of Technology

Sobriety monitoring system

A system and method of monitoring sobriety using a hand-held breath testing device that, on receipt of a user's breath, generates a breath test signal comprising substance content data and user identification data, and wirelessly transmits the breath test signal to a breath test signal receiving station. The breath test signal includes substance content data and user identification data.
Bi Mobile Breath, Inc.

Blood test kit, member thereof, and manufacturing the same

An object is to perform analysis of a target component contained in a small volume of blood sample at high accuracy using a normal component homeostatically present in blood. Provided is a blood test kit for analyzing a concentration of a target component in a blood sample by using a normal component homeostatically present in blood, the kit including: a diluent solution for diluting a blood sample; and a member selected from the group consisting of a first storing instrument in which the diluent solution is stored, a separating instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separating instrument, a second storing instrument for storing the recovered blood plasma, and a sealing instrument for keeping the stored blood plasma in the second storing instrument, in which an amount of the normal component which is derived from the member and may be contained in the diluent solution is defined..
Fujifilm Corporation

Blood analysis method and blood test kit

An object of the present invention is to provide a blood analysis method in which a high level of repeatability and reproducibility is achieved with respect to measurement values in a blood sample of 50 μl or less, and a blood test kit which is used for the blood analysis method. According to the present invention, a blood analysis method including a step of diluting a collected blood sample with a diluent solution; a step of determining a dilution factor by using a normal value of a normal component which is homeostatically present in the blood; and a step of analyzing a concentration of a target component in the blood sample, in which a volume of the blood sample is 50 μl or less, a dilution factor of blood plasma components in the blood sample is 14 or higher, and the diluent solution is a diluent solution which does not contain the normal component which is homeostatically present in the blood, is provided..
Fujifilm Corporation

Blood test kit and blood analysis method

An object of the present invention is to provide a blood test kit of which a component in a small volume of blood can be mailed in a safe state by controlling the influence of the outside temperature during the mailing, and a highly accurate blood analysis method in which coefficient of variation of a measurement value is reduced. According to the present invention, a blood test kit including a diluent solution for diluting a blood sample; a separating means for recovering blood plasma components from the diluted blood sample; a container for storing the blood plasma components recovered from the diluted blood sample; and a cold insulation means for cold-insulating the container, is provided..
Fujifilm Corporation

Method of measuring blood component, sensor used in the method, and measuring device

The present invention provides a method of measuring a component in blood, by which an amount of the component can be corrected accurately by measuring a hematocrit (hct) value of the blood with high accuracy and high reliability and also provides a sensor used in the method. The method of measuring a component in blood using a biosensor comprising a first electrode system including a first working electrode on which at least an oxidoreductase that acts upon the component and a mediator are provided and a first counter electrode and a second working electrode on which the mediator is not provided.
Panasonic Healthcare Holdings Co., Ltd.

Biological information measurement device, and biological informatoin measurement method using same

The present invention has an object of improving the measurement accuracy in a biological information measurement device, e.g., for measuring a blood glucose level. The device is configured to be able to change at least one of i) a voltage value to be applied to the second input terminal and the third input terminal (i.e., the blood component measurement counter electrode 7 and the blood component measurement working electrode 6) in the second biological information measurement mode d and ii) a voltage application time during which a voltage is applied to the second input terminal and the third input terminal in the second biological information measurement mode d based on the first biological information in the first biological information measurement mode a.
Panasonic Healthcare Holdings Co., Ltd.

Small volume in vitro analyte sensor

A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent.
Abbott Diabetes Care Inc.

System and optimizing insulin dosages for diabetic subjects

A method and system for optimizing insulin dosages for diabetic subjects which includes a processor for calculating basal and bolus dosages to be recommended for meal types including breakfast, lunch, dinner, snack, or at miscellaneous times. The bolus calculations are specifically directed to time periods which are taken from either pre-meal, post-meal, bedtime, mid-sleep or miscellaneous times.
Aseko, Inc.

Nucleated red blood cell analysis system and method

Systems and methods for analyzing blood samples, and more specifically for performing a nucleated red blood cell (nrbc) analysis. The systems and methods screen a blood sample by means of fluorescence staining and a fluorescence triggering strategy, to identify nuclei-containing particles within the blood sample.
Abbott Laboratories

White blood cell analysis system and method

Systems and methods for analyzing blood samples, and more specifically for performing a white blood cell (wbc) differential analysis. The systems and methods screen wbcs by means of fluorescence staining and a fluorescence triggering strategy.
Abbott Laboratories

System and analyzing blood cell

Provided are a system and a method for analyzing a blood cell. The system includes a laser generator installed around a moving path, along which an analysis target blood cell moves, to generate a laser beam; a plurality of photodetectors configured to detect a laser beam generated as a result of refraction, reflection, transmission or fluorescence of the laser beam generated from the laser generator and incident upon the analysis target blood cell; and an optical fiber configured to focus the laser beam generated from the laser generator and to irradiate the focused laser beam to a measurement point existing on the moving path, wherein the optical fiber transfers a laser beam scattered through a blood cell to the photodetectors; and an analysis apparatus configured to analyze the analysis target blood cell by using the laser beam detected by the photodetectors..
New Optics, Ltd.

Pressure measurement devices, methods, and systems

A pressure measurement pod for blood circuits can include a flexible, moveable, fluid-impermeable diaphragm and can be formed via either a one-shot or a two-shot molding process. A method of manufacturing a pressure measuring device can include providing first and second major mold parts having recesses defining major parts of a housing, and inserting pins in the first and second major mold parts, the pins being shaped to define a flow channel of a molded pressure measuring pod.
Nxstage Medical, Inc.

Lyophilization

Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma..
Terumo Bct, Inc.

Circulating tumor and tumor stem cell detection using genomic specific probes

The present disclosure comprises a method of detecting circular tumor cells and methods of detecting, evaluating, or staging cancer in a patient, as well as a method of monitoring treatment of cancer in a patient using the claimed method. In other embodiments, the method provides for directed to a method of determining the level of circulating tumor cells (ctcs) in a sample having blood cells from a patient by contacting a sample having blood cells from a patient..
Board Of Regents, The University Of Texas System

Blood component measurement device and blood component measurement method

Provided are a blood component measurement device and the like capable of further suppressing the errors in measuring blood components. A first current value that is generated by oxidation-reduction when a first voltage is applied to a first electrode pair 21, 22 composing a biosensor 1 is measured, a second current value that is generated when a second voltage is applied to a second electrode pair 23, 24 composing the biosensor 1 is measured, and then the first current and the second current are converted to give a blood component amount.
Panasonic Healthcare Holdings Co., Ltd.

Methods for controlling obesity using minimally invasive means

Methods for controlling obesity using minimally-invasive procedures including introducing embolic crystal particles that are naturally occurring and mostly non-toxic salts into the arterial capillaries feeding the sections of the stomach where the appetite inducing hormone, ghrelin, is produced to limit the blood flow to the region reducing appetite; introducing a virus vector or antisense oligonucleotide to inhibit the production of ghrelin and reduce the appetite; and introducing a soluble embolic particle with a virus vector or antisense oligonucleotide which will inhibit the flow of blood initially and then dissolve and release the inhibit vector to the region, generating ghrelin to control the appetite.. .

Biologic sample collection devices and methods of production and use thereof

Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a modified polycaprolactone (pcl). Methods of production and use thereof are also described herein.
Diomics Corporation

Thrombin-thrombomodulin fusion proteins as protein c activators

Compositions and methods for regulating the blood coagulation pathway are disclosed. More particularly, the present disclosure relates to thrombin-thrombomodulin fusion proteins, vectors, host cells and methods for preparing the thrombin-thrombomodulin fusion proteins.
Saint Louis University

Medical sample transportation container

A portable apparatus for transport and incubation of a medical sample in a blood culture flask includes a sealable container having a thermally insulated compartment for receiving the blood culture flask and a heater for heating the medical sample to a temperature suitable for pre-culturing of the sample. An agitator is provided for agitating the sample in the blood culture flask..
Q-linea Ab

Containers, bottles, drums, vats, and tanks having a slippery surface

The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces. Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as liquid b to repel a wide range of materials, referred to herein as object a (solid a or liquid a).
President And Fellows Of Harvard College

Antigen-binding proteins that antagonize leptin receptor

The present invention provides antibodies and antigen-binding fragments of antibodies that bind to leptin receptor (lepr), and methods of using the same. According to certain embodiments, the invention includes antibodies and antigen-binding fragments of antibodies that bind lepr and antagonize lepr signaling.
Regeneron Pharmaceuticals, Inc.

Antibodies that modulate immunity to drug resistant and latent mtb infections

The invention is directed to compositions and methods for stimulating, enhancing or modulating the immune system of a patient before or after infection by a pathogen, and in particular multidrug resistant (mdr) mtb and extremely drug resistant (xdr) mtb. Compositions of the invention contain non-naturally occurring antigens that generate an effective cellular and/or humoral immune response to mtb and/or antibodies that are specifically reactive to mtb antigens.
Longhorn Vaccines And Diagnostics, Llc

Bortezomib-based delivery system

The invention relates to a class of molecules obtained for conjugating a species or substrate to bortezomib by means of bonds of the boronic diester type which are stable in a neutral environment but which are capable of being degraded in a slightly acid environment (ph=4.5-5.0) releasing the drug bortezomib and which can also be conjugated on the surface of a cro-nanosystem (a type of substrate) for the delivery of drugs in such a way as to become a constituent thereof. They represent a class of bortezomib prodrugs with respect to hydrolysis of the boronic ester.
Nanosilical Devices S.r.i.

Nitrite salts of 1,1-dimethylbiguanide, pharmaceutical compositions, and methods of use

Provided herein are nitrite salts of 1,1-dimethylbiguanide; and isotopic variants thereof; and pharmaceutically acceptable hydrates and solvates thereof. Also provided herein are their pharmaceutical compositions and methods of use for treating, preventing, or ameliorating one or more symptoms of diseases associated with and/or caused by an abnormal blood glucose level.
Novomedix, Llc

Microorganism nucleic acid purification from host samples

The present disclosure provides systems, devices, and methods for purifying microorganism nucleic acid from a host sample, such as a whole blood sample from a human. In certain embodiments, devices and systems with multiple filters are employed and provide for the selective removal of blood cells and host nucleic acids from a sample in order to enrich for microorganism nucleic acid..
Abbott Molecular Inc.

Methods for segregating particles using an apparatus with a size-discriminating separation element having an elongate leading edge

The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are unable to pass through a narrower passageway bounded by a segregating step, resulting in segregation of the particles.
Angle North America, Inc.

Electrodes and electrode positioning systems for transvascular neuromodulation

Electrode systems for transvascular stimulation of target nerves include electrode arrays, elements promoting blood flow between electrode surfaces and surrounding vascular walls, electrodes shaped to promote more even current density than electrodes having angular edges, features for retaining the electrode systems with blood vessels, and features for using electrode-carrying elements to asymmetrically distend blood vessel walls towards target nerve structures.. .
Neurotronik Ip Holding (jersey) Limited

Systems and methods for treatment of fluid overload

Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system.
White Swell Medical Ltd

Methods and detecting and reacting to insufficient hypoglycemia response

A method for providing blood glucose data is provided. In response to a suspension of a continuous basal insulin delivery, by an insulin delivery pump, the method identifies a condition indicating continuing hypoglycemia that continues when basal insulin delivery is suspended; and performs an action, by the insulin delivery pump, based on identifying the condition..
Medtronic Minimed, Inc.

Infusion and blood collection devices and methods

An infusion and blood collection device allows clean blood collections into a collection tube via a previously installed angiocatheter without interrupting the administration of intravenous therapies after initial installation. The device optionally includes passive control of the blood collection flow rate to prevent contamination of the collected blood draw with the iv therapy fluid being simultaneously infused through the angiocatheter.
Medtg Llc

Detection of a disruption of a fluid connection between two fluid containing systems

A monitoring system (9) performs a method for detecting a disruption of a fluid connection between a first fluid containing system and a second fluid containing system. The monitoring system generates a monitoring signal (m1) which is representative of a fluid pressure in respect of the first fluid containing system and which is responsive to the disruption of the fluid connection, and a tracking signal (t1) which corresponds to and is more smoothed over time than the monitoring signal (m1).
Gambro Lundia Ab

Autoimmune mechanical immunomodulation

The present disclosure describes a novel therapeutic apheresis system and, more specifically, methods and an apparatus for performing therapeutic apheresis. The present disclosure provides highly efficient methods for therapeutic apheresis that modulate the immune system, thereby resulting in treatment of one or more underlying immunological disease processes.
Amina Sciences Llc

Systems and methods for oxygenator performance evaluation

Systems and methods for monitoring oxygenator performance in extracorporeal circuit systems or the like. More particularly, the disclosure relates to systems and methods including a controller programmed to determine oxygenator apparatus flow impedance as a function of an inlet pressure measurement, an outlet pressure measurement and a blood flow rate measurement.
Medtronic Vascular, Inc.

Dialysis system

A dialysis system includes a filtration system capable of filtering a water stream, a water purification system capable of purifying said water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process, and a dialyzer system. The dialyzer may be a microfluidic dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream..
Outset Medical, Inc.

Intravascular ventricular assist device

One aspect of an intravascular ventricular assist device is an implantable blood pump where the pump includes a housing defining a bore having an axis, one or more rotors disposed within the bore, each rotor including a plurality of magnetic poles, and one or more stators surrounding the bore for providing a magnetic field within the bore to induce rotation of each of the one or more rotors. Another aspect of the invention includes methods of providing cardiac assistance to a mammalian subject as, for example, a human.
Heartware, Inc.

Nanoparticle-medicated genetic delivery of growth inhibiting genes on balloon angioplasty to suppress intimal hyperplasia

The invention provides methods, devices, and reagents for treating a disease or a condition in a blood vessel, such as a venous or arterial disease or condition.. .
Board Of Education Of The Vocational Schools In Th E County Of Bergen

Sheath introducer for peripheral artery catheterization procedures

A sheath introducer facilitates the insertion of a catheter into a peripheral artery. The sheath introducer comprises longitudinally extending exterior and interior surfaces, the interior surface defining a lumen in which blood flow occurs.

Compositions for enhancing delivery of agents across the blood brain barrier and methods of use thereof

Compositions and methods for improved delivery of active agents to the brain are provided. The compositions typically include a nanocarrier, such as a polymeric nanoparticle, liposome, or nanolipagel or are in the form of a conjugate.
Yale University

Composition for preventing or treating bone disease, obesity and lipid-related metabolic disease

The present invention relates to a functional composition for preventing, alleviating or treating bone disease and lipid-related metabolic disease, and more particularly to a composition which comprises a combination of probiotics and a vitamin complex, which is capable of effectively preventing, alleviating or treating bone disease, obesity and lipid-related metabolic disease by synergistic effects on antioxidant activity, a reduction in blood lipid levels and the promotion of in vivo absorption of calcium and iron.. .
Cell Biotech Co., Ltd.

Compositions comprising cinnamaldehyde and zinc and methods of using such compositions

Compositions comprise an amount of cinnamaldehyde that is orally tolerable, thus avoiding an unpleasant mouth feeling, and also tolerable in the gastrointestinal tract. The cinnamaldehyde is supplemented by zinc, and the combination can be effective to increase at least one of energy expenditure, sympathetic nervous system activity, or fat oxidation.
Nestec S.a.

Microporous zirconium silicate for the treatment of hyperkalemia

The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. Potassium ions, from the gastrointestinal tract at an elevated rate without causing undesirable side effects.
Zs Pharma, Inc.

Inhalation of nitric oxide for treating respiratory diseases

A method of treating a human subject which is effected by intermittent inhalation of gaseous nitric oxide at a concentration of at least 160 ppm is disclosed. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder that can be treated via the respiratory tract.
Advanced Inhalation Therapies (ait), Ltd.

Contraceptive compositions and methods for improved efficacy and modulation of side effects

Compositions and methods for the delivery of progestin hormones that have binding affinity to the sex hormone binding globulin (shbg) are disclosed. The compositions combine such progestins with non-progestin shbg ligands to displace at least part of the progestin from shbg in the blood plasma, thereby increasing its bioavailability.
Agile Therapeutics, Inc.

Treatment using dantrolene

Provided are low-volume, safe for injection formulations of dantrolene yielding significant advantages over the currently approved and marketed dantrolene for malignant hyperthermia (mh) threatening anesthetic crisis. Once dantrolene can be made immediately available to patients triggered of mh, the anesthesiologist will be able to focus exclusively on the management of the patient's physiologic status in this complex and evolving crisis, not on the laborious and time consuming reconstitution process of the rescue agent.
Lyotropic Therapeutics, Inc.

Rivastigmine-containing sustained-release pharmaceutical composition

The present invention relates to a rivastigmine-containing sustained-release pharmaceutical composition and, more specifically, to a rivastigmine-containing sustained-release pharmaceutical composition, which is a sustained-release preparation containing a ph-dependent delayed release phase, wherein, by controlling the release of the pharmaceutical composition to be minimized in the stomach at the initial stage of administration, the pharmaceutical composition can lower the maximum blood concentration (cmax) compared with existing products while arriving at an effective blood concentration, thereby reducing side effects, and thereafter, maintaining the effective blood concentration through the sustained-release of main ingredients. As a result, the pharmaceutical composition according to the present invention exhibits the same effect as in the existing twice-a-day dosing through only the once-a-day dosing, and can increase the treatment efficiency of patients through the improvement in the convenience of administration of patients..
Navipharm Co., Ltd.

Intravascular heat exchange catheter with non-round coiled coolant path

A catheter has a hollow conduit through which working fluid from a heat exchange system flows. The conduit in turn is configured to extend along a longitudinal central axis in a continuously varying non-constant azimuthal orientation so that it defines a non-round enclosed passageway through which blood can flow to exchange heat through a wall of the conduit with the working fluid flowing within the conduit..
Zoll Circulation, Inc.

Mitral valve prosthesis with atrial anchoring

A method of treating a mitral valve without open-heart surgery is disclosed. An expandable prosthesis comprises an anchoring portion and an occluding member coupled to the anchoring portion.
Edwards Lifesciences Ag

Application of radiofrequency catheter ablation system to treatment of essential hypertension

An application of a radiofrequency catheter ablation system to treatment of essential hypertension. The treatment process is under ultrasonic guidance, an electrode needle is made to penetrate into target tissue of a patient, electrification is conducted to start ablation, the needle is withdrawn or made to penetrate into the other side of the target tissue for target ablation after reaching ablation temperature and duration time, and overall ablation treatment is completed.
Nanjing Khons Medtech Co., Ltd.

Materials and methods of using the same to improve structural integrity of a wall of a mammalian luminal organ

Materials and methods of using the same to improve structural integrity of a wall of a mammalian luminal organ. In an exemplary method of method for reinforcing a wall of a luminal organ, the method comprises the steps of inserting at least part of a needle into a blood vessel of a patient, advancing a distal end of the needle within the blood vessel to a location adjacent to a wall of a luminal organ of interest, piercing the wall of the luminal organ using the needle so that a tip of the needle is present within the wall of the luminal organ, injecting a substance through the needle and out of a distal portion of the needle so that at least some of the substance is present outside of the needle and inside of the wall of the luminal organ to reinforce the wall of the luminal organ..

Intravascular catheter having an expandable incising portion for incising atherosclerotic material located in a blood vessel

A method for performing balloon catheterization of a zone of attention is provided. An intravascular device has an expandable portion secured to a distal end of a catheter tube.

Intravascular catheter with incising devices

An intravascular device is provided having a flexible catheter tube with an expandable portion located on an end thereof. The expandable portion has a plurality of struts capable of being moved between an expanded and a collapsed position.

Axial lengthening thrombus capture system

Disclosed herein are systems and methods to remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (pe), deep vein thrombosis (dvt), cerebrovascular embolism, and other vascular occlusions.. .
Kp Medcure, Inc.

System and blood typing using ppg technology

A biosensor identifies a blood type using photoplethysmography (ppg) technology. A ppg circuit obtains a plurality of spectral responses at a plurality of wavelengths detected from skin of a user.
Sanmina Corporation

Lancet holding device and methods of use thereof

A blood lancing device and, more particularly, to an ergonomic blood lancet holding device and methods of use thereof that allow for single-handed operation, particularly by individuals with limited or no operational function in one arm or hand and by individuals with body tremors. Additional embodiments provide a universal lancet securing means for detachable holding of various proprietary lancet shapes, designs and formats that are presently or may become commercially available.

System and methods for processing analyte sensor data

Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor.
Dexcom, Inc.

Long-term implantable monitoring system & methods of use

Methods and systems include a long-term implantable ultra-filtrate monitoring system that uses micro-porous membranes to produce an ultra-filtrate of tissue interstitial fluid or blood plasma. The ultra-filtrate is transported through a sensor to detect a level of analyte in the ultra-filtrate.
Thomas Jefferson University

Blood pressure measurement device, blood pressure measurement method, and recording medium

A blood pressure measurement device estimates blood pressure based on first internal pressure of cuff during a first period and korotkoff sound during the first period or based on the first internal pressure during the first period and first pulse wave during the first period; calculates timings when the first pulse wave satisfies a predetermined condition, a third period between timings, and pressure of first internal pressure during the third period and generates first information where the third period and the pressure are associated; generates blood pressure information where the calculated first information and the estimated blood pressure are associated; and specifies the first information matching or resembling second information generated based on second internal pressure of the cuff during second period and second pulse wave during the second period, and estimates the blood pressure associated with the specified first information as blood pressure during the second period.. .
Nec Corporation

Method and system for evaluating blood vessel

A method and system for evaluating physiological properties of a segment of blood vessel is provided. The method includes: acquiring a first measurement and a second measurement respectively at the first point and the second point; obtaining a transfer function configured to produce an output given an input, using the first measurement and the second measurement as the input and the output respectively; and determining the physiological properties of the section of the blood vessel based on the transfer function.
The Uab Research Foundation

Scanned laser vein contrast enhancer imaging in an alternating frame mode

The present invention is a miniature vein enhancer that includes a miniature projection head. The miniature projection head may be operated in one of three modes, afm, dbm, and rtm.
Accuvein, Inc.

Efficient and interactive bleeding detection in a surgical system

A bleeding detection unit in a surgical system processes information in an acquired scene before that scene is presented on a display unit in the operating room. For example, the bleeding detection unit analyzes the pixel data in the acquired scene and determines whether there are one or more initial sites of blood in the scene.
Intuitive Surgical Operations, Inc.

Mapc treatment of brain injuries and diseases

The invention relates to the treatment of various injuries, disorders, dysfunctions, diseases, and the like of the brain with mapcs, particularly in some aspects, to the treatment of the same resulting from hypoxia, including that caused by systemic hypoxia and that caused by insufficient blood supply. In some further particulars the invention relates, for example, to the treatment of hypoxic ischemic brain injury with mapcs, in children for example, and to the treatment of cortical infarcts and stroke with mapcs in adults, for example..
Longwood Gardens, Inc.

Devices for reducing left atrial pressure, and methods of making and using same

A device for regulating blood pressure between a patient's left atrium and right atrium comprises an hourglass-shaped stent comprising a neck region and first and second flared end regions, the neck region disposed between the first and second end regions and configured to engage the fossa ovalis of the patient's atrial septum; and a one-way tissue valve coupled to the first flared end region and configured to shunt blood from the left atrium to the right atrium when blood pressure in the left atrium exceeds blood pressure in the right atrium. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits.
Longwood Gardens, Inc.

Multilevel intelligent interactive mobile health system for behavioral physiology self-regulation in real-time

An automated method for personal health management of a user having a personal user profile, the method including repeatedly measuring a plurality of health parameters by a mobile electronic device, the health parameters including a heart rate variability, a blood pressure, a motion activity, and a weight of the user, calculating a base line dataset by the computing device for each one of the plurality of health parameters for a predetermined period of time, comparing recently measured health parameters from the step of repeatedly measuring with the base line dataset, providing on a display that is operatively connected to the computing device a first raw feedback on a health performance of the user based on the step of comparing, repeatedly prompting the user to answer contextual questions, the contextual questions related to at least one of physical, mental, emotional, and behavioral status of the user, and generating a second detailed feedback based on the personal user profile, the baseline data set, the measured health parameters, and a given context, to determine values for a plurality of health segments, and providing the second detailed feedback to the display of the user, based on a request by the user that includes the given context and data of the plurality of health segments.. .
Talislife Sàrl

Insulin management

A method of managing insulin includes receiving blood glucose measurements on a computing device from a glucometer. The blood glucose measurements are separated by a time interval.
Aseko, Inc.

Subcutaneous outpatient management

A method of administering insulin includes receiving subcutaneous information for a patient at a computing device and executing a subcutaneous outpatient program for determining recommended insulin dosages. The subcutaneous outpatient program includes obtaining blood glucose data of the patient from a glucometer in communication with the computing device, aggregating blood glucose measurements to determine a representative aggregate blood glucose measurement associated with at least one scheduled blood glucose time interval, and determining a next recommended insulin dosage for the patient based on the representative aggregate blood glucose measurement and the subcutaneous information.
Aseko, Inc.

Diabetes management therapy advisor

A method includes obtaining training data for a plurality of patients of a patient population. The training data includes training blood glucose history data including treatment doses of insulin administered by the patients of the patient population and one or more outcome attributes associated with each treatment dose.
Aseko, Inc.

Pre-symptomatic diagnosis of a viral illness

A method for a pre-symptomatic diagnosis of a viral illness includes obtaining a biological sample with a peripheral blood mononuclear cell from a subject. The method further includes stimulating the biological sample, where the stimulation of the biological sample includes adding to the biological sample a predetermined amount of antigen configured to trigger a t-cell ifn-γ response in the biological sample and a predetermined amount of reagent configured to capture the t-cell ifn-γ response.
The Johns Hopkins University

Cxcl13 as an indicator of germinal activity and immune response

Presented herein are methods of detecting and/or monitoring germinal center activity in a subject according to an amount of cxcl13 in the blood of a subject. Also presented herein are methods of determine the efficacy of a vaccine or antigen at inducing an immune response.
La Jolla Institute For Allergy And Immunology

Biomarker for psychiatric and neurological disorders

The purpose of the present invention is to provide: a biomarker for psychiatric and neurological disorders, in particular, a biomarker for diagnosing psychiatric and neurological disorders; and a test kit and test method for psychiatric and neurological disorders. The inventors discovered that there is a significant increase in the concentration of free κ immunoglobulin chains and free λ immunoglobulin chains in the blood samples from patients with psychiatric and neurological disorders.
Resvo Inc.

Method for the in vitro prediction of the probability of a patient developing severe dengue, based on a blood sample

A kit for in vitro prediction of severe dengue includes a binding partner specific for leucine-rich alpha-2 glycoprotein, a binding partner specific for vitamin d-binding protein, and a binding partner specific for ferritin. The kit may further include at least one binding partner specific for a dengue virus protein wherein the dengue virus protein is the ns1 protein, the envelope protein, or the prm protein..
Biomerieux

Immunochromatographic test strip and detection method using immunochromatography for detecting target in red blood cell-containing sample

A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions..
Sekisui Medical Co., Ltd.

Hepatocyte culture device capable of enhancing accumulation and excretion of hepatic metabolite in and into bile canaliculus-like structure, and evaluating candidate compound sensitive to excretion into bile or blood and hepatic metabolite of said candidate compound using said hepatocyte culture device

The present invention is a hepatocyte culture device enhancing accumulation and excretion of a hepatic metabolite in and into a bile canaliculus-like structure, the device including: a first cell culture containing a plurality of hepatocytes; a portable culture vessel in which the bile canaliculus-like structure can be established between the hepatocytes in the first cell culture, and that has, on an outer surface of the culture vessel, a membrane through which a physiologically active substance can pass; and a second cell culture capable of improving excretion activity of a hepatic metabolite in the first cell culture, in which the first cell culture cultured in the portable culture vessel is disposed on the second cell culture to be co-cultured.. .
National Agriculture And Food Reserach Organization

Process for separating nucleated cells from non-nucleated red blood cells

The present disclosure provides processes for the separation of nucleated cells from non-nucleated red blood cells, populations of cells obtainable by the processes of the disclosure, and devices and kits useful in the processes of the disclosure.. .
Mesotex, Inc.

Blood coagulation analysis method, blood coagulation analyzer, and computer program

A blood coagulation analysis method according to an embodiment includes: calculating blood coagulation time based on data which represents a coagulation curve indicating a temporal change in an optical detection value of a blood specimen added with a measurement reagent; and determining an early reaction error by using a result of determination of conformity between a shape of the coagulation curve represented by the data and a shape of a reference coagulation curve.. .
Sysmex Corporation

Method of measuring hematocrit and testing blood

A method of measuring hematocrit and a method of testing blood are provided. The method for measuring hematocrit includes the following steps.
Industrial Technology Research Institute

Method for measuring blood components and biosensor and measuring instrument for use therein

The present invention provides a method of measuring a component in blood, by which the amounts of blood cells and an interfering substance can be measured with high accuracy and high reliability and the amount of the component can be corrected accurately based on the amounts of the blood cells and the interfering substance. In a sensor for measuring a blood component, a first working electrode 13 measures a current that flows during a redox reaction of a blood component, a second working electrode 17 measures the amount of blood cells, and a third working electrode 12 measures the amount of an interfering substance.
Panasonic Healthcare Holdings Co., Ltd.

Biological fluids concentration assembly

A biological fluids concentration device, including a tube-in-tube assembly, is disclosed. The tube-in-tube assembly receives biologic fluids and may then be placed in the bucket of a centrifuge and spun to separate out the components of the biological fluid by their various densities.
Alliance Partners Llc

Method and automated analysis

An apparatus for pretreatment of a sample of whole blood in a discrete fluid analyzing instrument comprises automated means for handling and analyzing the sample and means for performing a pretreatment step on the sample or a sub-sample of the sample. The means for pretreatment are used for immobilizing at least one substance or analyte from the sample or sub-sample wherein the substance or analyte is reversibly immobilized.
Thermo Fisher Scientific Oy

Strain sensing element, pressure sensor, microphone, blood pressure sensor, and touch panel

According to one embodiment, a strain sensing element provided on a deformable substrate, includes: a first magnetic layer; a second magnetic layer; and an intermediate layer. The second magnetic layer includes fe1-yby (0<y≤0.3).
Kabushiki Kaisha Toshiba

Non-invasive automatic monitoring of pet animal's core temperature

A system, device and method monitoring whether a core temperature of a warm-blooded pet animal is within a normal range for the pet animal comprises a sensing assembly including (i) a skin temperature sensor positioned such that a sensing surface of the skin temperature sensor faces the animal, the skin temperature sensor configured to produce a skin temperature output, (ii) an ambient temperature sensor spaced away from the animal and configured to produce an ambient temperature output, and (iii) an accelerometer for sensing an acceleration of the pet animal and producing an acceleration output; and a processor for receiving the outputs, calculating an activity level from the acceleration data and determining whether the core temperature of the pet animal is within the normal range based on a pre-defined function relating the skin temperature ts, the ambient temperature ta, and the activity level of the pet animal.. .
Petpace Ltd.

Novel risk biomarkers for lung cancer

Methods and kits for determining a risk of a subject, or subjects for developing lung cancer is disclosed. The method comprises determining a level of catalytic activity of n-methylpurine dna glycosylase (mpg), or apurinic/apyrimidinic endonuclease 1 (ape1), or both, or mpg and 8-oxoguanine dna glycosylase (ogg1), or mpg and ape1 and ogg1 in peripheral blood cells of a subject, wherein levels of mpg above a predetermined reference value, or ape1 or ogg1, or a integrated dna repair score below a predetermined reference value is indicative of an increased risk of developing lung cancer..
Yeda Research And Development Co. Ltd.

Modified cells for production of blood cells

A genetically modified cell (e.g., stem cell) containing a complete or partial gene deletion of one or more genes of a blood group antigen (bga) biosynthesis or transportation pathway is provided. The systems and methods provided herein facilitate the generation of blood substitutes (e.g., blood cells)..
Shanghai Sidansai Biotechnology Co., Ltd

Method for inactivation/removal of coagulation factors by precipitation

A method for inactivation or removal of coagulation factors vii, fvii, fviia, fix, fixa, fx, fxi and fxia inor from protein containing solutions obtained from blood, blood plasma, plasma fractions or by recombinant means wherein the protein containing solution is contacted with an organic acid or its salt while being stirred.. .
Octapharma Ag

Compositions and methods for the treatment of carboxyhemoglobinemia

Described herein is a new antidote for the rapid elimination of carbon monoxide from hemoglobin, including brain, heart, and red cell hemoglobin. The disclosed therapy involves the use of modified human globins, particularly neuroglobins modified at residue 64 and cytoglobins modified at residue 81, which bind carbon monoxide with extremely high affinity.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education

Peptide with anti-obesity and anti-diabetes activity and use thereof

A peptide and a peptide complex of the present invention exhibit an anti-obesity effect by inhibiting fat accumulation and decomposing already accumulated fat, and exhibit an excellent effect with respect to diabetes by effectively reducing blood sugar. The peptide and the peptide complex of the present invention decrease the expression of pparγ, acc, and ap2, which are adipogenic markers, increase the expression of phsl, ampk-α1, cgi-58, and atgl, which are lipolytic factors, and reduce the size of fat cells and blood cholesterol values.
Caregen Co., Ltd.

Pde10 inhibitors and related compositions and methods

Compounds that inhibit pde10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as parkinson's disease, huntington's disease, alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, bell's palsy, cerebral palsy, sleep disorders, pain, tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided.
Omeros Corporation

Sk and ik channel agonists for treatment of heart failure

The present invention provides compounds that are improved potassium channel agonists. Pharmaceutical compositions including a pharmaceutically acceptable carrier and a compound of the present invention are also provided.
The Trustees Of Columbia University In The City Of New York

Measuring cartridge and liquid transport method

A measuring cartridge and a liquid transporting method capable of improving measurement accuracy of plasma components by suppressing contamination of blood cell components when transferring plasma components separated by centrifugation are provided. The measuring cartridge 10 includes a first storage part 31 and a second storage part 32 which is disposed in a direction away from the rotating shaft 20 with respect to the first storage part 31 and has a width in the rotation direction around the rotating shaft 20 larger than that of the first storage part 31; a separation chamber 30 for separating the blood sample into a blood cell component and a plasma component by utilizing centrifugal force caused by rotation around the rotating shaft 20, a flow path connected to an inner wall of at least one of the first storage part 31 or second storage part 32.
Sysmex Corporation

Catheter-based devices and associated methods for immune system neuromodulation

Catheter-based devices and associated methods for immune system neuromodulation of human patients are disclosed herein. One aspect of the present technology is directed to methods of treating a human patient diagnosed with an immune system condition.
Medtronic Ardian Luxembourg S.a.r.l.

Catheter system for acute neuromodulation

A neuromodulation system includes a first therapy element adapted for positioning within a superior vena cava, and a second therapy element adapted for positioning within a pulmonary artery. The first therapy element is carried on a first elongate flexible shaft, and the second therapy element is carried on a second elongate flexible shaft.
Interventional Autonomics Corporation

Abrading balloon catheter for extravasated drug delivery

A method of extravasated drug delivery is disclosed, including inserting a catheter with a first balloon, a second balloon, and a third balloon positioned between the first and second balloons and having a wall with an abrasive outer surface, into a bodily cavity, inflating the first and second balloons to create a chamber therebetween, stimulating a flow of blood cells by inflating the third balloon until the abrasive outer surface abrades tissue, and delivering the agent to the chamber. A balloon catheter system is also provided including a balloon having a wall with an abrasive outer surface for abrading tissue, a catheter having a first lumen for supplying fluid to the balloon to inflate the balloon such that the abrasive surface stimulates a flow of blood cells, and a second lumen for supplying an agent to tissue..
Sanovas Intellectual Property, Llc

Controlling the uniformity of pecvd deposition

A method and apparatus for plasma modifying a workpiece such as a syringe barrel, cartridge barrel, vial, or blood tube is described. Plasma is provided within the lumen of the workpiece.
Sio2 Medical Products, Inc.

System for managing glucose levels in patients with diabetes or hyperglycemia

A blood glucose maintenance system for use by hyperglycemic individuals measures their blood glucose level and calculates an appropriate glucose or insulin dosage based on the measurement. Recheck intervals responsive to dosage history are determined.
Indiana University Health, Inc.

Warburg effect targeted chemotherapy apparatus

A system for chemotherapy delivery comprises a plurality of slots to receive a corresponding one of a plurality of cartridges; a plurality of pumps, wherein each of the plurality of pumps is configured to be connected to the corresponding one of the plurality of cartridges, and the plurality of pumps are configured to pump at least one drug contained in at least one of the plurality of cartridges to a patient according to a treatment protocol; a blood glucose sensor communicatively coupled to the plurality of pumps, and configured to measure a blood glucose level of the patient; a processor connected to the plurality of pumps and the blood glucose sensor and configured to adjust a delivery property of the at least one drug according to the measured blood glucose level of the patient.. .
Cure Cancer Worldwide Llc

Blood treatment device priming devices, methods, and systems

Simple-to-use systems, methods, and devices for priming replacement blood treatment devices, for swapping the blood treatment devices out, for replacing swapped-out blood treatment devices, and other related operations are described. In embodiments, a blood treatment device can be primed while a therapy is still running.
Nxstage Medical, Inc.

Bioartificial liver device

A bioartificial liver device including a bioreaction chamber having a plurality of semi-permeable membranes and a plurality of filter spaces each confined by two adjacent semi-permeable membranes; a plurality of liver cell perfusion ports each communicating with one of the filter spaces for introducing the liver cells into the filter spaces, and a positive peristaltic pump. In the device, the semi-permeable membranes are disposed substantially horizontal with respect to the ground, and the positive peristaltic pump is adapted to drive the plasma flow from the bottom wall of the device to the top wall.
Wuhan Togo Meditech Co., Ltd

Integrated on-line monitoring and thermostatic heating bioartificial liver device

An integrated on-line monitoring and thermostatic heating apparatus for a bioartificial liver device, the apparatus including a blood inlet, a blood pump, an arterial drip chamber, a bioreactor module, a venous drip chamber, and a blood reinfusion port which are connected in sequence. The bioreactor module includes a thermostatic water tank and a bioreactor disposed in the thermostatic water tank.
Wuhan Togo Meditech Co., Ltd

Systems for establishing supplemental blood flow in the circulatory system

A blood circulation assist system comprising an inflow cannula having a lumen and an insertion device configured to be received therein and to facilitate insertion of a portion of the inflow cannula into a heart chamber. The insertion device includes a shaft having distal and proximal end portions and a plurality of lumens.
Circulite, Inc.

Method for conveying a medium with a pump and pump comprising a rotor, a housing and a drive

A method for conveying blood or priming liquid as a medium using a blood pump, measures gas in the medium in a feed line to the pump, in or on the pump, and the pump power is increased only for a short time as a function of the measured gas. A blood pump, in particular a centrifugal pump or diagonal pump, includes a rotor, a housing and a drive, the pump including a gas detector which acts upon the drive when gas is detected..
Xenios Ag

Single-piece volute

A blood pump casing including a unitary body. The unitary body defines an inlet chamber extending along a first axis and having a first radius perpendicular to the first axis.
Heartware, Inc.

Device for cardiocirculatory assistance

A device for cardiocirculatory assistance constituting a pump for a blood flow includes a body, a pair of covers, and a pair of membranes. The device is provided with a circuit for the passage of a gas or gaseous fluid alternatively under pressure and depressurization so that a reciprocating pumping motion of the membranes is established..
Ellebi Fin Llc

Wound-healing and hemostatic sponge of squid ink polysaccharide/chitosan, preparation method and use thereof

A wound-healing and hemostatic sponge of squid ink polysaccharide/chitosan, a preparation method and use thereof are provided. The sponge comprises squid ink polysaccharide and chitosan as carriers and calcium chloride as an initiator for blood coagulation, and the wound-healing and hemostatic sponge of squid ink polysaccharide/chitosan is achieved via a lyophilization technology.
Guangdong Ocean University

Perfusive organ hemostasis

Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in nephron-sparing surgeries, which produces a completely bloodless surgical field, allowing speedy resection. In certain embodiments, after a certain amount of time, the flow gradually resumes, with no apparent adverse consequences to the kidney.
Genzyme Corporation

Fluorescent compound comprising a fluorophore conjugated to a ph-triggered polypeptide

The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided..
Yale University

Thrombus imaging aptamers and methods of using same

Provided herein are imaging agents, antidotes to the imaging agents and methods of using the same to image a thrombus or blood clot or thrombin including sites of thrombin accumulation and to diagnose and treat thrombosis. The imaging agents include an aptamer capable of binding the thrombus or thrombin in particular linked to a reporter moiety.
Duke University

Composition for preventing or treating obesity or lipid-related metabolic disease

The present invention provides a pharmaceutical composition and a food composition for preventing or treating lipid-related metabolic disease, which contain, as active ingredients, probiotics and a vitamin b complex. When the composition comprising the probiotics and the vitamin b complex is used, it may further promote in vivo absorption of the vitamin b complex, and may induce a synergistic effect on a reduction in blood lipid levels, thereby exhibiting an effect on the alleviation, prevention or treatment of obesity and lipid-related metabolic disease..
Cell Biotech Co., Ltd.

Pharmaceutical compositions for combination therapy

The present application relates to a pharmaceutical composition comprising a combination of an fxr agonist and at least one additional therapeutic agent that lowers the glucose level in the blood, stimulates insulin secretion, and/or increases insulin sensitivity. The present application relates to use of the pharmaceutical composition for the treatment or prevention of a fxr mediated disease or condition, such as nafld and nash, a disease or condition related to an elevated level of glucose in the blood, decreased secretion of insulin, and/or decreased insulin sensitivity such as hyperglycemia, diabetes, obesity, and insulin resistance, or for lowering the glucose level in the blood, stimulating insulin secretion, and/or increasing insulin sensitivity..
Intercept Pharmaceuticals, Inc.

Myoelectric prosthesis and method

A method of transferring intrinsic hand muscles along with a respective nerve and blood supply; and allowing signal detection by a surface electrode is provided. The method further includes transferring muscles of a forearm along with a respective nerve and blood supply; and allowing signal detection by a surface electrode..

Prosthesis for repairing a blood vessel and method

A prosthesis for repairing a blood vessel, wherein the prosthesis is inserted intraluminally and fixed in the vessel so as to isolate a diseased section thereof and maintain the flow of blood from the vessel to collateral vessels involved the diseased section, and the prosthesis comprises a stent support and a flexible fabric liner of woven material comprising a plurality of concentric layers, wherein each of said layers has a very open fabric web which allows the passage of blood flow through the layers during the installation or the prosthesis but which allows the sealing of layers once the prosthesis is installed. A method is also provided for safe installation of the prosthesis..

Patient-specific virtual intervention laboratory to prevent stroke

The present application relates to systems and methods for performing a computerized cardiac simulation for at least one of diagnosis, risk assessment or treatment planning including: receiving, by a computer, a plurality of three-dimensional cardiac images of a subject's heart such that each three-dimensional cardiac image corresponds to a different phase of a single cardiac cycle of the subject's heart; modeling structure, using the computer, of the left atrium of the subject as a function of time using the plurality of three-dimensional cardiac images of the subject's heart; modeling blood flow, using the computer, within, into and out of the left atrium of the subject as a function of time using computational fluidic dynamics and using structure of said left atrium obtained from at least one of said plurality of three-dimensional cardiac images or said modeling structure of said left atrium; simulating at least one of time dependent structural function or time-dependent blood flow of said left atrium using results from said modeling structure and said modeling blood flow for a selected period of time; and providing information to a user from said simulating for use in at least one of diagnosis, risk assessment or treatment planning for a physiological effect related to function of said left atrium of the subject.. .
The Johns Hopkins University

Methods and systems for optimizing perivascular neuromodulation therapy using computational fluid dynamics

Methods and systems for optimizing perivascular neuromodulation therapy using computational fluid dynamics. Digital data regarding three-dimensional imaging of a target blood vessel and corresponding hemodynamic data are inputs to generating a computational fluid dynamics (cfd) model.
Medtronic Ardian Luxembourg S.a.r.l.

Devices and methods for excluding the left atrial appendage

Devices and methods are described for occluding the left atrial appendage (laa). The device excludes the laa from blood flow to prevent blood from clotting within the laa and subsequently embolizing, particularly in patients with atrial fibrillation.
Conformal Medical, Inc.

String phantom with four independent parameters for evaluation of doppler ultrasonography instruments

Doppler ultrasound systems are valuable diagnostic tool for investigation of vascular blood flow pattern and velocity. Error in blood velocity measurements made by doppler instruments will cause probable misdiagnosis in clinical practice.

Wearable monitoring device

A system, method, and device for monitoring a physiological characteristic and/or response of a user includes a wearable monitoring device for displaying a status level of a physiological characteristic and/or response. When attached to or against the user's body, the wearable monitoring device includes an optical signal assembly configured to generate an optical signal based on a reflection or transmission of light from a detected travel of blood and/or pulse wave of the user and received by one or more sensors disposed along the user's extremity.
Garmin Switzerland Gmbh

System and a biosensor integrated in a vehicle

A vehicle includes one or more integrated biosensors, such as finger sensors or other user touchpoints. The integrated biosensors are configured to obtain biosensor data, such as a patient's vitals or concentrations of substances in the blood flow of a user.
Sanmina Corporation

Blood pressure estimation by wearable computing device

According to one aspect of the present disclosure, a method for estimating blood pressure is provided, comprising training a machine learning model on a cohort data set. The cohort data set may include subject-specific contextual data, time-varying features, and blood pressure measurements for a plurality of subjects.
Microsoft Technology Licensing, Llc

System and methods of determining etiology of undiagnosed symptomatic events

Embodiments describe a method of determining etiology of undiagnosed events comprising monitoring electrocardiogram signals and blood pressure of a patient via a medical device, capturing one or more of an ecg segment and a bp reading in response to a triggering event, classifying one or more of the ecg segment and bp reading as normal or abnormal, and determining etiology of undiagnosed symptomatic events based on the classification. Embodiments further describe a medical device comprising sensors for monitoring ecg signals and bp of a patient, circuitry for capturing one or more of ecg segments and bp readings of a patient in response to a triggering event, and a processor for communicating one of more of captured ecg segments and captured bp readings to a remote monitoring center directly or indirectly where the captured ecg segments and captured bp readings are classified as normal or abnormal..
Medtronic Monitoring, Inc.

Medical information bracelet

A medical information bracelet for storing and retrieving medical information from a user. The medical information bracelet includes a housing disposed on an elongated strap, wherein the housing comprises a visual display screen and a non-transitory computer readable medium.

Computer-based diabetes management

A computer-based method includes receiving, from a computer-based user interface, user-specified information about one or more events influential on the user's blood glucose level, generating, with a computer-based processor, a plurality of estimated trajectories of the user's blood glucose level as influenced by the one or more events, receiving a set of data that represents actual blood glucose measurements for the user, and identifying, with the computer-based processor, which of the estimated trajectories represents a best fit to the set of data that represents the actual blood glucose measurements for the user. At least some of the actual blood glucose measurements occurred later in time than a start time of the one or more events influential on the user's blood glucose level.
Bigfoot Biomedical, Inc

Multiport blood collection device

A multiport blood collection device includes a rearward retaining portion including three couplers, each configured to receive a respective blood sample container, a forward adapter portion configured to receive a connector through which tubing coupled to a hypodermic needle is coupled to the device, and a branched passageway within the device to simultaneously divert blood extracted by the hypodermic needle from the tubing through the connector to respective blood sample containers inserted in each of the couplers. The paths through the multiport blood collection device to each of the couplers are coplanar, are symmetric about the device body, and have the same diameter.
S2 Medtech, Llc

Strain sensing element, pressure sensor, microphone, blood pressure sensor, and touch panel

According to one embodiment, a strain sensing element is provided on a film unit configured to be deformed. The strain sensing element includes a functional layer, a first magnetic layer, a second magnetic layer, and a spacer layer.
Kabushiki Kaisha Toshiba

Blood pressure signal acquisition using a pressure sensor array

A system and method for blood pressure signal acquisition using a pressure sensor array. A solution is provided for a non-inflatable, non-invasive, continuous blood pressure waveform and blood pressure acquisition system.
Guardlyff S.a.

Computer-implemented identifying zones of stasis and stenosis in blood vessels

In a first aspect, the current invention concerns a computer-implemented method, system and computer program product for identifying a zone in a blood vessel system with a risk level for stasis, comprising the following steps: a) providing an angiogram of a blood vessel system, said angiogram comprising a time series of images of said blood vessel system, at least some of said images showing a contrast agent present in said blood vessel system; b) identifying at least one zone within said blood vessel system on a multitude of images of said time series; c) characterising variations in grey-scale intensity in said zone across at least part of said time series of images; d) characterising an outflow of said contrast agent from said zone on the basis of said variations in intensity in said zone; and e) providing a local risk level for stasis in said zone. In further aspects, the current invention also concerns a computer-implemented method, system and computer program product for identifying a zone in a blood vessel with a risk level for stenosis and stent malpositioning, and for measuring the coronary flow reserve (cfr)..
Coronary Technologies Sarl

Temporary or long term implantation device for intracranial probes having hematoma detection apparatus, and using device thereof

A biopsy needle surrounded by a peel away sheath chemically impregnated with a blood detection composition enabling a user (e.g., a surgeon) to accurately and timely determine the existence of a blood pooling or hematoma when passing an implantable (e.g., deep brain stimulation probes) or non-implantable (e.g., biopsy needle) device into a region of the subject's body (e.g., a brain) to gather tissue for further analysis. A biopsy needle may be provided wherein the needle is tightly surrounded by a peel-away sheath that is chemically impregnated with a blood detection composition.

Methods, systems and devices for creating a blood flow pathway to treat a patient

Provided is a system for creating an arteriovenous flow pathway in a patient, comprising: a vessel-to-vessel guidewire; a needle delivery device constructed and arranged to place the vessel-to-vessel guidewire from a starting vessel to a target vessel; a flow creation device constructed and arranged to be advanced over the vessel-to-vessel guidewire and to create a flow pathway between the starting vessel and the target vessel; and a stent for positioning in a vessel. At least one of the starting vessel or the target vessel is a vein, and the other of the starting vessel or the target vessel is an artery.
Rox Medical, Inc.

High temporal resolution doppler oct imaging of retinal blood flow

Techniques are introduced to improve the ability of oct to determine more accurately the nature of the flow of fluids in the eye, including faster measurements of the flow and a method to reduce geometric uncertainties due to eye movements.. .
Carl Zeiss Meditec, Inc.

Ophthalmic image display device and ophthalmic imaging device

An ophthalmic image display device having, a display controller that displays a b mode image, a blood vessel enhanced image representing a same cross section as the b mode image, and one or more front images individually formed based on a three dimensional data set acquired by performing optical coherence tomography on a subject's eye in a predetermined layout. Further, the display controller displays a cross section position indicator that indicates a position of a cross section of the b mode image over at least one of the one or more front images.
Kabushiki Kaisha Topcon

Method for cooking a chicken with an overcooked rice crust

The present invention relates to a method for cooking a chicken with an overcooked rice crust. The method may include a pre-processing step of thoroughly removing the contents and the blood from a raw chicken; a chicken-seasoning step of soaking the pre-processed chicken in mixed water of clean water and a salting agent for seasoning the chicken for a certain period of time; a high-temperature cooking step of filling the inside the belly of the salted chicken with glutinous rice and angelica gigas and roasting the chicken with oak firewood and oak-wood charcoal; and an overcooked rice crust cooking step of flatly pushing and laying the glutinous rice, boiled within the belly of the chicken, on agalmatolite with a high-heat maintenance rate, laying the chicken on the said glutinous rice, and cooking in such a manner of making a gratine of overcooked rice crust at a high temperature..
Kyelimwon F&b

Systems and methods for medical diagnosis and biomarker identification using physiological sensors and machine learning

Predictive healthcare systems utilize the signal produced by physiological and, in some embodiments, environmental sensors to infer, computationally, a physiological parameter of the patient. The physiological sensors may include a vibro-acoustic sensor in contact with a patient over at least the frequency band 0.001 hz to 40 khz and a bio-electric sensor.

Technique simulator

A procedure simulator that includes an animal heart to which a first balloon is inserted into a left ventricle of the heart and to which a second balloon is inserted into a right ventricle of the heart. A pump system makes the first balloon and the second balloon expand and contract via an operating fluid (l).
Terumo Kabushiki Kaisha

System and a blood flow simulator

A blood flow simulator generates a compression and expansion in a test fluid that emulates the pressure waveform created by a heartbeat in blood flow. The blood flow simulator stores a plurality of pressure waveform files that include actual data recorded from a heartbeat, arterial pressure waveform, or venous pressure waveform.
Sanmina Corporation

Methods and kits for labeling, detection and isolation of foxp3+ regulatory t cells, isolated population of foxp3+ regulatory t cells thus obtained and uses thereof

Disclosed is a method for labeling, detecting and/or isolating foxp3+ treg cells from a biological sample containing peripheral blood mononuclear cells (pbmc) or lymphocytes including the following steps of: (i) coupling the surface of pbmc or lymphocytes to a capture moiety which binds to the cell through a cell surface molecule and to interleukin-34 (il34), (ii) culturing the lymphocytes under conditions wherein il34 is secreted, released and specifically captured by the capture moiety, (iii) labeling the il34 expressing lymphocytes with a label moiety, and (iv) optionally detecting and/or isolating the il34 expressing lymphocytes which are foxp3+ treg cells. Also disclosed is an isolated population of foxp3+ treg cells obtainable by the method and uses thereof..
Centre Hospitalier Universitaire De Nantes

Collecting components of a fluid

Embodiments are described for separating/collecting components from a multi-component fluid such as whole blood. Some embodiments provide for controlling the amount of a component, such as platelets, introduced into a separation chamber to ensure that the density of fluid in the separation chamber does not exceed a particular value.
Terumo Bct, Inc.

Total protein measurement using whole blood refractometry

An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions.
Instrumentation Laboratory Company

Biological fluids concentration assembly

A biological fluids concentration device, including a tube-in-tube assembly, is disclosed. The tube-in-tube assembly receives biologic fluids and may then be placed in the bucket of a centrifuge and spun to separate out the components of the biological fluid by their various densities.
Alliance Partners Llc

Cold storage health monitoring system

A monitoring system for a cold storage device such as a vapor compression refrigerator or freezer. The monitoring system learns operating characteristics of the cold storage device and issues alarm notifications when abnormal behavior is detected.
Emanate Wireless, Inc.

Identifying presence and composition of cell-free nucleic acids

This disclosure describes example techniques and systems for identifying the presence and/or composition of nucleic acids in the blood of a host organism of a model species harboring tissue of a donor organism of another species. For example, the technique may involve identifying the presence and composition of nucleic acids in the blood of a mouse harboring tissue of a human or another companion animal.
Regents Of The University Of Minnesota

Treatment of cancers with micro-rna inhibitors

The invention relates to the treatment and prevention of cancers, including blood-based cancers and breast cancers, by administering agents that inhibit the activity of micrornas, including mir-22. Inhibitors can include oligonucleotides that are at least partially complementary to these mirnas.
Beth Israel Deaconess Medical Center

Secreted ap2 and methods of inhibiting same

A method of reducing a symptom of a clinical disorder characterized by aberrantly elevated circulating ap2 is carried out by administering to a subject an inhibitor of secreted ap2, secretion of ap2, or a serum ap2 blocking agent. For example, glucose intolerance is reduced following administration of such an inhibitor or agent.
President And Fellows Of Harvard College

Pyridyl benzothiophenes as kinase inhibitors

This invention is directed to compounds, which are useful as protein kinase (pk) inhibitors and can be used to treat such diseases as cancer, blood vessel proliferative disorders, fibrotic disorders, mesangial cell proliferative disorders, metabolic diseases inflammatory disorders and neurodegenerative disorders.. .
Allergan, Inc.

Centrifuge

Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (prp) and or platelet poor plasma (ppp) can be obtained rapidly and is ready for immediate injection into the host.
Dsm Ip Assets, B.v.

Venous anatomy drug delivery balloon

Balloon catheters that deliver therapeutic agents are functional only for treatment of the arterial anatomy and result in inefficient dispersion of the therapeutic agent to the arterial tissue due to dispersion through the secondary balloon holes under high pressure. A method and drug delivery balloon device for efficient drug delivery to the targeted point of the anatomy comprising a first balloon wholly enveloped by a second balloon composed of a porous membrane that delivers the therapeutic agent to the targeted point upon the introduction of low pressure to the secondary balloon membrane.
Divergent Life Sciences Llc

Systems and methods for peripheral vascular cannulation

Systems and method for peripheral cannulation are provided. Systems include cannulas defining fenestrations that can be exposed or occluded by a cover slip to selectively expose fenestrations to blood flow in an artery or vein..
The Cleveland Clinic Foundation

Implantable blood conveying device, manipulating device and coupling device

An implantable component is described which is connectable to a manipulating device in a self-retaining manner by a coupling device, which provides a first coupling element and a second coupling element. The implantable component can thus be really positioned by the manipulating device which can, for example, already be connected to the implantable component before a therapeutic procedure and can be separated therefrom again after the surgical procedure.
Berlin Heart Gmbh

Devices and methods for managing chest drainage

Disclosed is a chest drainage system which reduces or eliminates pooling of blood/liquid and/or clogging/clotting in the drainage tube and/or chest tube, and provides objective and accurate measures of drained fluid volume and chest air leak. The chest drainage system continuously monitors chest tube and drainage tube status and clears pooled liquid in the drainage tube, and/or a clogged chest tube when necessary to restore negative pressure to the chest..
Esculon, Llc

Drug-eluting device for prophylaxis or treatment of a disease or pathology

The invention disclosed herein generally relates to particular intravascular drug-eluting delivery devices and methods for manufacture and use in either the prophylaxis or treatment of a disease or pathology. In one aspect, the drug eluting prosthesis is implanted into a patient's blood vessel upstream of a disease site..
Fluid Biotech Inc.

Substrate having an electron donating surface with metal particles comprising palladium on said surface

There is disclosed a substrate with an electron donating surface, characterized in having metal particles on said surface, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of said metal particles is from about 0.001 to about 8 μg/cm2. Examples of coated objects include contact lenses, pacemakers, pacemaker electrodes, stents, dental implants, rupture nets, rupture mesh, blood centrifuge equipment, surgical instruments, gloves, blood bags, artificial heart valves, central venous catheters, peripheral venous catheters, vascular ports, haemodialysis equipment, peritoneal dialysis equipment, plasmapheresis devices, inhalation drug delivery devices, vascular grafts, arterial grafts, cardiac assist devices, wound dressings, intermittent catheters, ecg electrodes, peripheral stents, bone replacing implants, orthopaedic implants, orthopaedic devices, tissue replacing implants, intraocular lenses, sutures, needles, drug delivery devices, endotracheal tubes, shunts, drains, suction devices, hearing aid devices, urethral medical devices, and artificial blood vessels..
Bactiguard Ab

Clay-based hemostatic agents

A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting.
Z-medica, Llc

Therapeutic pooled blood apoptotic cell preparations and uses thereof

Cell preparations comprising a pooled and enriched, mononuclear apoptotic cell population, and a method of preparing this cell preparation are described. The pooled mononuclear apoptotic cell preparation may be obtained from pooled, allogeneic white blood cell fractions that are pooled prior to or following induction of apoptosis.
Enlivex Therapeutics Ltd.

Methods of treatment and pharmaceutical compositions using bcn057 or bcn512

The present disclosure is directed to method of treatment for treating or ameliorating various conditions pertaining such as bone marrow recovery (or blood cell production), fibrosis, inflammatory diseases, inhibition of cancer cell growth, propagation or malignancy, thrombocytopenia, wound healing, and conditions related to stem cells by the administration of bcn057, 512, or an analog thereof.. .
Bcn Biosciences L.l.c.

Internal shunt and treating glaucoma

A surgical technique and device wherein an indwelling tube is placed in the eye of a patient having glaucoma. The tube diverts aqueous humor from the anterior chamber to the suprachoroidal space from which it is removed by blood flowing in the choroidal and uveal tissues.
Novartis Ag

Implantable flow adjuster

An implantable flow adjuster (20) includes proximal and distal support rings (22, 24) which support a flow adjuster panel (26). The flow adjuster panel (26) divides the lumen through the device (20) into two sections, one of reducing cross sectional area and the other of increasing of increasing cross sectional area.
Cook Medical Technologies Llc

Method of removing a thrombus from a blood vessel

A method for mechanically capturing and removing a thrombus from a blood vessel includes advancing a guidewire into the thrombus. A self-expanding body is allowed to expand in the blood vessel, wherein the self-expanding body is fixed to a distal end portion of an elongate catheter.

Method of treating migraine headache using ultrasound and electrocautery or radiofrequency ablation

A method for treating headaches caused by a blood vessel irritating an associated nerve. The method is performed using a doppler ultrasound device and a treatment device (e.g., electrocautery or radiofrequency ablation).

Embolus removal device with blood flow restriction and related methods

A clot removal device has an expandable treatment member having a distal tip and a proximal end, a delivery wire having a distal end coupled to the proximal end of the expandable treatment member, and a flow restrictor carried along the delivery wire at a location that is separate and proximal from the expandable treatment member. The flow restrictor has a body with a distal section and a proximal section, the distal section being covered and the proximal section being uncovered.
Neurovasc Technologies, Inc.

Flexible vascular occluding device

A vascular occluding device for modifying blood flow in a vessel, while maintaining blood flow to the surrounding tissue. The occluding device includes a flexible, easily compressible and bendable occluding device that is particularly suited for treating aneurysms in the brain.
Covidien Lp

Fluid titration system

A fluid titration system has an optical sensor, a physiological monitor, a titration controller and an infusion device. The optical sensor transmits multiple wavelengths of light into a tissue site of a person and detects the optical radiation after attenuation by pulsatile blood flowing within the tissue site.
Masimo Corporation

Electronic providing blood sugar care service

An apparatus and a method for providing blood sugar care service are provided. The method includes obtaining blood sugar information of a user, when the blood sugar information is obtained for a predetermined time unit, generating a blood sugar profile based on the blood sugar information obtained during the predetermined time unit, comparing the generated blood sugar profile and a previously generated blood sugar profile, setting a blood sugar profile proximate to a normal blood sugar range as a target profile, and providing a state of blood sugar of the user based on the set target profile, thereby providing a customized blood sugar care state suitable to each user in consideration of the state of blood sugar of individuals..
Samsung Electronics Co., Ltd.

Blood glucose monitoring device and monitoring method thereof

Embodiments of the present disclosure provide a blood glucose monitoring device and a monitoring method thereof, which can reduce the influence of the oral environment on the measurement accuracy. The blood glucose monitoring device comprises: a housing; a micro-current stimulation module connected to two electrodes and generating a current, the two electrodes being located on a surface of the housing and the current stimulating the parotid gland of a user through the two electrodes to produce fresh saliva; a saliva glucose acquisition module configured to acquire a glucose concentration in the saliva; a control processing module configured to control the micro-current stimulation module to work and to obtain a blood glucose concentration value from the glucose concentration..
Boe Technology Group Co., Ltd.

Device, evaluating the microcirculation of blood in a tissue

A device for evaluating the microcirculation of blood in human or animal tissue. The device having a housing with an open end for contact with said tissue and thus delimit a study area of said tissue.

Device for treatment of aneurysm

A device for treating a vascular aneurysm of a human or mammal patient, comprising an implantable member adapted to hold fluid, the implantable member being adapted to be placed against an outside of a blood vessel having the aneurysm, exercise a pressure on the aneurysm to prevent or reduce an expansion of the aneurysm, follow an outer contour of the aneurysm, and provide a pressure that is equal or less than the diastolic blood pressure of the human or mammal patient.. .

Cannula insertion detection

Sensors are disclosed that detect whether a cannula is properly inserted to its full depth in a subject's skin. The sensors may be used with a blood glucose monitor, or with a continuous insulin infusion pump, infusion set, or other system involving intermittent or continuous testing and/or drug delivery..
Becton, Dickinson And Company

Non-invasive intracranial pressure monitoring system and method thereof

A system which includes a first sensor placed proximate to a perfusion field of an artery receiving blood which emanates from the cranial cavity is configured to monitor pulsations of the artery receiving blood which emanates from the cranial cavity artery. A second sensor placed proximate to a perfusion field of an artery which does not receive blood emanating from the cranial cavity configured to monitor pulsations of the artery which does not receive blood emanating from the cranial cavity.
Vivonics, Inc.

Device for extraction of peaks from continuous intracranial pressure waveform and detection the same

The present invention relates to a device and a method for detecting a peak of an intracranial pressure (icp) waveform using a morphological feature of an arterial blood pressure waveform. A peak extracting method of an icp waveform using a morphological feature of an arterial blood pressure waveform according to an aspect of the present invention includes: extracting a pulse onset from a continuous icp waveform based on systolic peak from arterial blood pressure waveform; dividing individual icp waveforms in the continuous icp waveform based on the pulse onset; deriving a derivative value from each of the icp waveforms to extract a peak, a trough, and a flat; calculating latencies from the pulse onset extracted in each of the icp waveforms to the extracted peaks to cluster peaks with a similar time interval and generate a peak cluster; searching a notch from each of the icp waveforms based on the latency of a dicrotic notch of the arterial blood pressure waveform; and extracting p1, p2, and p3 peaks from each of the icp waveforms by referring to the searched notch of the icp..
Korea University Research And Business Foundation

System and non-invasively monitoring intracranial pressure

A system and method for non-invasively monitoring intracranial pressure are provided. In some aspects, the method comprises acquiring diffuse correlation spectroscopy data at a temporal resolution greater than a pulsatile frequency of cerebral blood flow of a subject using one or more optical sensors placed about a subject, and determining a pulsatile cerebral blood flow using the acquired data, the method also includes correlating the determined pulsatile cerebral blood flow with physiological data acquired from the subject, and estimating an intracranial pressure based on the correlation.
The General Hospital Corporation

An improved blood pressure measurement system

A blood pressure measurement system is able to measure actual blood pressures. More specifically, the blood pressure sensor or sphygmomanometer is able to detect high frequencies that exist only between systole and diastole, and thus identify aspects such as micro-pulses associated with the opening and closing of an artery to achieve accurate blood pressure readings..
A C Cossor & Son (holdings) Limited

Physiological sensor delivery device and method

An intravascular sensor delivery device for measuring a physiological parameter of a patient, such as blood pressure, within a vascular structure or passage. In some embodiments, the device can be used to measure the pressure gradient across a stenotic lesion or heart valve.
Acist Medical Systems, Inc.

Method, apparatus, and program for outputting index

A method for outputting an index for determining a condition of a blood vessel includes acquiring a diastolic blood pressure for each of upper and lower limbs of a living body, calculating a ratio of the diastolic blood pressure acquired in the acquiring step of the lower limb to the diastolic blood pressure acquired in the acquiring step of the upper limb, and outputting the ratio of the diastolic blood pressures calculated in the calculating step.. .
Nihon Kohden Corporation

Personalized pediatric nutrition products comprising human milk oligosaccharides

The present disclosure generally relates to personalized nutritional compositions for pediatric subjects, wherein the nutritional composition can include one of three distinct profiles of human milk oligosaccharides (hmos). The present disclosure also relates to methods for determining the composition of hmos present in or that would be present in the breast milk of the mother of a pediatric subject as determined by the mother's secretor status and/or lewis blood group, and providing to the pediatric subject a nutritional composition comprising an hmo profile most similar to the hmos present or that would be present in the breast milk of the subject's mother..
Mead Johnson Nutrition Company

Systems and methods for monitoring of fractional gluconeogenesis and targeting of fractional gluconeogenesis via nutritional support

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“bes”) of a patient, are disclosed. The bes provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient.
Run Them Sweet Llc

Systems and methods for monitoring of fractional gluconeogenesis and targeting of fractional gluconeogenesis via nutritional support

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“bes”) of a patient, are disclosed. The bes provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient.
Run Them Sweet Llc

Device and simulation of surface bleedings

The invention relates to a device to simulate a surface bleeding, comprising: —a source of a blood liquid, in particular a synthetic blood liquid or a blood liquid having been removed from a human body; a pump system connected to the source of blood liquid and configured to provide a controlled flow of said blood liquid; a wound simulator having an open chamber connected to the pump system to receive the controlled flow of blood liquid, wherein the wound simulator comprises a set of interchangeable plates, each plate having a plurality of holes arranged through said plate according to a specific pattern, wherein the specific pattern is different for each plate of the set of interchangeable plates, and. Each plate being adapted to be removably mounted on the wound simulator to close the open chamber, so that blood liquid flows out of the chamber through the holes of the plate mounted on the wound simulator.
Biom'up

Pet blood tester, pet blood test system, and pet blood testing method thereof

A pet blood tester includes a reader configured to read identification information of a pet from a tag; an analyzer configured to analyze blood of the pet to acquire information on the blood; a storage; a controller configured to receive stored body information of the pet corresponding to the identification information from at least one of an external device and the storage if the stored body information of the pet corresponding to the identification information is stored in at least one of the external device and the storage; and an inputter configured to receive input body information of the pet from a user if the body information of the pet corresponding to the identification information is not stored in at least one of the external device and the storage, wherein the controller is further configured to provide a blood test result and diagnosis information for the pet, based on the information on the blood, and the stored body information of the pet or the input body information on the blood.. .
Samsung Electronics Co., Ltd.

52-gene signature in peripheral blood identifies a genomic profile associated with increased risk of mortality and poor disease outcomes in idiopathic pulmonary fibrosis

The clinical course of idiopathic pulmonary fibrosis (ipf) is difficult to predict. Described herein is a peripheral blood 52-gene expression signature useful to improve outcome prediction in ipf..
Yale University

Method for discriminating symptom of hepatic disease

Provided is a noninvasive method for determining the presence of a symptom of a hepatic disease such as nonalcoholic fatty liver disease with a higher diagnostic accuracy. A method for discriminate between nonalcoholic fatty liver (nafl) and nonalcoholic steatohepatitis (nash), the method comprising: (1) a step of measuring the quantities of marker molecules contained in blood collected from a subject; (2) a step of determining an index value from a normalized score calculated based on the quantities of the marker molecules belonging to the same group; and (3) a step of determining that the subject is possibly affected with nash in the case that the index value is larger than a reference value..
Sumitomo Dainippon Pharma Co., Ltd.

Methods and devices for integrating analyte extraction, concentration and detection

Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum.
The Regents Of The University Of California

Blood pump with separate mixed-flow and axial-flow impeller stages, components therefor and related methods

A rotordynamic pump for delivering continuous flow of fluids, such as blood, is provided. In one embodiment, the pump includes a stator housing having an inlet and an outlet.
Worldheart Corp.

Systems and methods for autologous biological therapeutics

An autologous cell concentrating system and method are disclosed. The system has a blood separation component, a first vessel, a second vessel, a first valve, a second valve, and a concentration and flow logic and control component.
Greyledge Technologies, Llc

Composition enriched in anti-a and /or anti b polyclonal immunoglobulins

The present invention relates to a composition highly enriched in anti-a and/or anti-b polyclonal immunoglobulins, comprising human polyclonal immunoglobulins, characterized in that at least 80% by weight of the human polyclonal immunoglobulins present in the composition are human anti-a and/or anti-b polyclonal immunoglobulins. The invention also relates to a method for preparing such a composition, and to the use of the composition for preparing a positive control that can be used in a method for assaying anti-a and/or anti-b activity of human normal immunoglobulins, and to use of the composition for determining an individual's blood type..
Laboratoire Francais Du Fractionnement Et Des Biotechnologies

Surgical drain line stripping devices

Medical drain lines tend to become clogged with blood or pus and thereafter lose their efficacy. Devices can be used for stripping blockages from medical drainage lines.
Mayo Foundation For Medical Education And Research

Apparatus and measuring recirculation

An apparatus for measuring recirculation using thermodilution during extracorporeal blood treatment including a temperature varying unit arranged to cyclically heat and/or cool blood in a venous tube segment of the blood tube system for a quasi-continuous recirculation measurement; and a detecting device configured to measure a variation of a physical parameter resulting from the heating and/or cooling. The detecting device is arranged to detect, in a case free from recirculation, a first physical parameter and to detect, in a case afflicted with recirculation, a physical parameter varied by the cooling and/or heating of the blood by the temperature varying unit as a second physical parameter in the blood tube system.
B. Braun Avitum Ag

Vad integrated flow sensor

A blood pump with an integrated flow sensor is provided. The blood pump may include an implantable pump for pumping blood having a housing, a flow path extending within the housing and at least one movable element within the housing for impelling blood along the flow path and a sensor for measuring the flow rate of blood through the pump.
Heartware, Inc.

Silver motor stator for implantable blood pump

In one embodiment of the present invention, an implantable blood pump includes a housing defining a flow path, a rotor positioned within the flow path, and a motor including a stator, positioned outside of said housing, the stator including a length of silver wire, wherein the silver wire is not positioned within a hermetically sealed compartment once the blood pump is ready for implantation into a patient in need thereof. The present invention may also include a method of implanting the implantable blood pump including the step of implanting the blood pump within the patient and within or adjacent to the vasculature..
Heartware, Inc.

Organic compounds

The present invention relates to novel pyridinoxy phenylpropanamines, their pharmaceutical compositions and methods of use. In addition, the present invention relates to therapeutic methods that penetrate the blood-brain barrier and regulate the norepinephrine and serotonin transporters (“net/sert”)..
Intra-cellular Therapies, Inc.

Treatment of peripheral vascular disease using protein solutions

Methods of treating peripheral vascular disease comprising administering a protein solution site of a defect at least two proteins from the group il-1ra, stnf-ri, stnf-rii, igf-i, egf, hgf, pdgf-ab, pdgf-bb, vegf, tgf-β1, and sil-1rii. The solution may also comprise white blood cells, platelets, concentrated bone marrow aspirate, and combinations thereof..
Biomet Biologics,llc.

Aortic valve reconstruction training kit

A training kit is provided for practicing aortic valve reconstruction. The aortic valve reconstruction training kit is provided with a blood vessel model and multiple valve leaflet models, and the blood vessel model has a base-capped or base-uncapped cylindrical form having an opening formed on at least the top part thereof.
Japanese Organization For Medical Device Development, Inc.

Medical devices and methods of use

Systems, and methods of disassembling systems that includes a medical device, a shaft that is optionally steerable, and a handle assembly. The methods can include providing a system after it has been exposed to a blood environment of a subject, disconnecting a medical device electrical contact from an electrical contact on the printed circuit board, moving the medical distally relative to the sheath and out of the distal end of the sheath, and cleaning at least a portion of the medical device..

Blood vessel sizing device

Medical devices and methods that provide for improved accuracy when positioning of a synthetic structure, such as a mems device or a stent, within a biological feature of a patient, such as a blood vessel, are disclosed. A blood vessel sizing device is configured for placement on the skin of a patient near a feature of interest (e.g.
Sizer Llc

Methods, devices, and systems for blood flow

Various exemplary methods, systems, and devices for blood flow are provided. In general, an implant can be configured to be implanted in bone and to delay clotting of blood flowing from the bone.
Medos International Sarl

Devices and methods for a totally percutaneous collapsible aortic punch

A method and device for perforating an aortic valve to remove excessive calcium deposits on aortic valve leaflets improves the implantation of tavi replacement valves in patients. By removing excessive calcium deposits, the radial pressure exerted by implanted tavi replacement valves is reduced, such that there is less blood leakage around the valve and less stress on the cardiac conductive system.

Devices and methods for improving transcatheter aortic valve implantation

A method and device for perforating an aortic valve to remove excessive calcium deposits on aortic valve leaflets improves the implantation of tavi replacement valves in patients. By removing excessive calcium deposits, the radial pressure exerted by implanted tavi replacement valves is reduced, such that there is less blood leakage around the valve and less stress on the cardiac conductive system.

Deploying and fixating an implant across an organ wall

Implant deployment device for delivering and deploying an implant. Includes: deployment device body for pushing implant in subject's blood vessel, across an interatrial septum and into subject's heart left atrium; and a handle operatively connected to deployment device and having controls assigned to selectively operate positioning of the deployment device, to facilitate determining compression extent of an implant body, and detaching of deployment device from the implant.
Vectorious Medical Technologies Ltd

Cardiac injury device

A device, method, and use of a device for temporary management of a wound, such as a wound in a heart. The device has a shaft, a blood flow blocking membrane at the first end of the shaft for blocking blood flow through the wound, and an abutment member that is mounted to the shaft and is axially movable along the shaft towards and away from the blood flow blocking membrane for abutting the wound and holding the blood flow blocking membrane adjacent the wound.

Apparatus and determining blood flow velocity

Apparatus and method comprising an ultrasound transmitter, for placement at a first location on the body of a subject, to emit an ultrasound pulse; an ultrasound receiver, for placement at a second location on the body, to detect an emitted ultrasound pulse; and a controller in communication with the transmitter and receiver. The controller causes an ultrasound pulse to be emitted by the transmitter; receives a measurement signal from the receiver; determines, based on the received measurement signal, a time of arrival at the receiver, t1 s of a first part of the emitted ultrasound pulse; determines, based on the received measurement signal, a time of arrival at the receiver, t2, of a second part of the ultrasound pulse; and calculates, using t1 and t2, a flow velocity of blood in a blood vessel between the first location and the second location..
Koninklijke Philips N.v.

Non-invasive glucose monitoring system

A blood monitoring system employs a finger holder capable of receiving and stabilizing fingers of various sizes. A blood monitoring system employs a bandpass filter array capable of reducing optical crosstalk..
Medika Healthcare Co., Ltd.

System and synchronizing external compression of a limb for increased blood

Embodiments relate to devices, systems and methods of assisting blood flow return to the heart from a limb. The device comprising a wearable garment (115) and a compression apparatus (110) embedded in the garment (115) for applying an external compression according to a compression sequence to a muscle of a limb of a user based on real-time measurements regarding a cardiac cycle having a diastolic phase and systolic phase of the user and real-time measurements of muscle activity.
Lockheed Martin Corporation

Medical image processing apparatus

According to one embodiment, a medical image processing apparatus includes first specifier, second specifier, determiner and display controller. First specifier collates an ischemic region calculated from a blood vessel visualized into a three-dimensional image in a plurality of phases with a dominating region of the blood vessel, and specifies a culprit vessel in the ischemic region.
Toshiba Medical Systems Corporation

Sekisui Medical Co., Ltd.

. .

Qiagen Gmbh

. .

User reminding method and apparatus, and terminal device

A user reminding method and apparatus, and a mobile terminal includes, obtaining, by a terminal device, a physical status of a user and a first blood pressure value of the user when a time difference between a current time and a preset reminding time is less than a first threshold; determining a first safety level based on the physical status and the first blood pressure value; and sending a first reminding signal in a manner corresponding to the first safety level.. .
Huawei Technologies Co., Ltd.

Blood management method, blood management server apparatus, and blood management system

A blood management method, a blood management server apparatus, and a blood management system are provided. The blood management method includes acquiring information about a blood recipient, determining a transfusable blood for the blood recipient based on the blood recipient information, searching for the determined transfusable blood in a blood supplier database (db), and transmitting a request for use of the transfusable blood or a blood donation request for the transfusable blood according to whether the transfusable blood is found in the blood supplier database (db)..
Samsung Electronics Co., Ltd.

Sample handling system

A sample processing system is configured for analyzing, preprocessing, or carrying out other operations for a biological sample such as blood or urea. With the sample processing system, it is possible to store samples to be stored in a thermally insulated state or specimens required for accuracy control in the thermally insulated state for preventing evaporation or denaturing of the samples and specimens.
Hitachi High-technologies Corporation

Analyte detection and methods therefor

Disclosed are methods and systems for analyte detection in a sample and more particularly, a biological sample. Methods and systems particularly relate to differentiating and/or identifying cell types in biological samples, such as blood samples, by adding antibodies specific to predetermined cd antigens.
Orphidia Limited

Electrode assembly for measurement of platelet function in whole blood

A platelet impedance measurement system including an electrode assembly allows for measurement of platelet function in blood. The assembly includes a substrate that acts as a substantially rigid base and includes an electrode.
Ca Casyso Gmbh

Methods for complete blood count measurement

The disclosure relates to devices and methods for analyzing blood cells in a sample. In various embodiments, the present disclosure provides devices and methods of performing complete blood count (cbc) testing.
Cytochip Inc.

Lubricant regulating agent

The present invention makes the insertion perception during actual surgery to be equivalent to the insertion perception of a catheter into a blood vessel model when water is used as the circulating fluid. A lubricant regulating fluid primarily composed of water is mixed with an aqueous metal salt and a surfactant as a lubricant regulating agent of the lubricant regulating fluid.
Fain-biomedical Inc.

Engineered opsonin for pathogen detection and treatment

The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (mbl), which is an abundant natural serum protein that is part of the innate immune system.
President And Fellows Of Harvard College

2-acylaminopropoanol-type glucosylceramide synthase inhibitors

Or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by structural formula (i) or a pharmaceutically acceptable salt thereof.

Plastic salt container for bloody mary mixes

A plastic salt container (1) is provided comprising a top lid (2) having outside threads (4) and inside threads of the top lid (2) which threadedly engage the base of the container (3) and more specifically, respectively engage outside threads (6) and inside threads (7) of the container base (3). The salt container (1) is fastened together by the internal threading of the top, outside thread (4) interlocking with the base's outside threads (6) and also the top lid inside threads (5) interlocking with the base's inside threads (7).

Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the gi tract. Many embodiments provide a swallowable device for delivering the agents.
Rani Therapeutics, Llc

Multi-use blood control safety catheter assembly

A valve actuator that moves in a catheter assembly between a first position where a valve is closed and a second position where the valve is open, the valve actuator including a shaft portion at a distal end of the valve actuator that is configured to pierce the valve, a mating portion at a proximal end of the valve actuator that is configured to engage a luer device, a diameter reduction region that connects the shaft portion and the mating portion, and a plurality of windows that extend through the valve actuator for flushing fluid, the plurality of windows being disposed in the diameter reduction region, wherein each of the plurality of windows does not extend a full length of the diameter reduction region.. .
Becton, Dickinson And Company

Catheter for insertion into branched blood vessel

A branch blood vessel insertion catheter has a catheter body having a lumen penetrating therethrough from a distal end of the catheter body to a proximal end thereof to allow a guide wire to be inserted therethrough. The catheter body has an inner layer, a wire-wound reinforcing member provided on an outer surface of the inner layer, and an outer layer covering both the inner layer and the reinforcing member.
Terumo Clinical Supply Co., Ltd.

Infusion pump system and methods

Some embodiments an infusion pump system can be configured to modify alarm limit parameters as the user's insulin load increases or decreases. Moreover, in particular embodiments, the infusion pump system can be configured to provide a “missed bolus” or “missed meal” alarm in response to the user's blood glucose characteristics, the user's insulin load information, or the like..
Bigfoot Biomedical, Inc.

Targeted apheresis using binding agents or ligands immobilized on membranes

This invention teaches a method of targeted apheresis that can be used to treat a variety of different diseases including infectious diseases, autoimmune disorders, and reducing circulating biomarkers associated with certain disorders e.g. Pre-eclampsia.

Dialysate free artificial kidney device

A device and method are described for the treatment of blood, which device may be used in conjunction with or in place of a failed kidney. The device includes an ultrafiltration unit to remove proteins, red and white blood cells and other high molecular weight components, a nanofiltration unit to remove glucose, at least one electrodeionization unit to transport ions from the blood stream, and a reverse osmosis unit to modulate the flow of water, to both the blood and urine streams.
Curion Research Corporation

Ventricular assist devices

An implantable blood pump includes a control unit storing patient specific settings. The control unit is configured to store patient specific settings.
Tc1 Llc

Kits, formulations and solutions having enzymatically- permissive amounts of visualization agents and uses thereof

The invention relates to a proteolytic enzyme which is capable of forming fibrin when it reacts with fibrinogen, a fibrin-glue kit and a fibrin-glue formulation comprising an enzymatically-permissive concentration of a visualization agent and to their use in methods for prevention and/or reduction of adhesions and/or methods for promotion of blood coagulation sealing or filling body surfaces.. .
Omrix Biopharmaceuticals Ltd.

A treatment and compounds for use therein

The present invention relates generally to a method of therapeutically or prophylactically treating ischaemia-induced myocardial tissue damage, in particular ischaemia-reperfusion-induced myocardial tissue damage. More particularly, the present invention relates to a method of reducing the extent of ischaemia-induced myocardial tissue damage in a mammal by selectively upregulating fpr1-mediated erk signalling.
Monash University

Injectable formulation

An object of the present invention is to provide a sustained-release injectable preparation which is in a medication administration form that can provide the effect of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1h-quinolin-2-one for a prolonged period of time, the preparation releasing a therapeutically effective amount of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1h-quinolin-2-one for at least one week. The present invention provides an injectable preparation containing 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1h-quinolin-2-one or a salt thereof as an active ingredient, which releases the active ingredient in such a manner that its blood concentration is maintained for at least one week..
Otsuka Pharmaceutical Co., Ltd.

Pharmaceutical composition for treatment or prevention of neurodegenerative diseases

There is provided a pharmaceutical composition for treatment or prevention of a neurodegenerative disease, comprising an rxr agonist as an active ingredient, which is a compound represented by formula (1) or (2). The pharmaceutical composition is effective in treatment or prevention of neurodegenerative diseases such as dementia, parkinson's disease and multiple sclerosis with reducing side effects such as enlargement of the liver and elevation of blood triglyceride level.
National University Corporation Okayama University

Identification and use of very long chain dicarboxylic acids for disease diagnosis, chemoprevention, and treatment

A method for determining colorectal cancer risk includes obtaining a blood sample of the subject, isolating serum or edta plasma from the blood sample, analyzing the serum or edta plasma to determine plasma levels of very long chain dicarboxylic acid (vlcdca 28:4), comparing the determined plasmas level of vlcdca 28:4 of the subject with a predetermined range of plasma levels of vlcdca 28:4 of diagnosed subjects having colorectal cancer, and determining a colorectal cancer risk exists when the determined plasma level of vlcdca 28:4 is within the predetermined range of plasma levels of vlcdca.. .
Lincoln Memorial University

Hyaluronic acid-based amphiphilic polymer, preparation method and application thereof

Disclosed are a hyaluronic acid-based amphiphilic polymer, preparation method and application thereof. A main chain of the amphiphilic polymer is a hydrophilic hyaluronic acid and can be employed in active targeting, and a side chain thereof is a hydrophobic group represented by formula (1).
Brightgene Bio-medical Technology Co., Ltd.

Platelet-like proteo-microparticles and using such in drug delivery

Proteo-microparticles such as proteoliposomes comprising a microparticle (e.g., a liposome) and platelet membrane proteins, wherein the proteo-microparticles are capable of binding to monocytes, neutrophils, or other circulating blood cells capable of migrating to an injured site. Also provided herein are uses of the proteoliposomes for delivering a therapeutic agent via monocytes to an injured site..
Academia Sinica

Composition for serum or plasma separation, and container for blood collection

Wherein r3 is an alkyl group having 1 to 4 carbon atoms; and r1 and r2 are independently a hydrogen atom or a linear or branched alkyl group having 1 to 8 carbon atoms.. .

Mechanical compression device for treating or preventing deep vein thrombosis and associated complications

A portable, mechanical compression device for preventing or treating deep vein thrombosis and extremity edema is provided herein. The device includes a frame that is placed in whole or in part around a limb, and a plurality of compression units that compress the limb, thereby mechanically facilitating circulation.
Institute For Cancer Research D/b/a The Research Institute Of Fox Chase Cancer Center

Methods for delivering and using a stent

Disclosed is a method, apparatus, and kit for assisting the expansion of a self-expanding stent, especially within highly curved or tortuous blood vessels. An elongated pusher having an expandable distal mesh portion can be positioned within a self-expanding stent, expanding during delivery to provide extra expansion force to the stent to ensure the stent properly expands..
Microvention, Inc.

Expandable valve prosthesis with sealing mechanism

A prosthetic heart valve includes at least one sealing member. The sealing member is adapted to conform to any surface irregularities found on the inner surface of the valve annulus, including any calcium deposits formed on the valve leaflets.
Mayo Foundation For Medical Education And Research

Percutaneuous temporary aortic valve

Methods and apparatuses for regulating aortic regurgitation are provided. A catheter shaft is advanced through vasculature so that a flexible occluding membrane coupled to the catheter shaft is positioned within the aorta, typically the ascending aorta above the sinus of valsalva and coronary ostia.
Hocor Cardiovascular Technologies Llc

Blood filter devices, systems, and methods of using the same to detect the presence of a thrombus within said filter devices

Blood filter devices, systems, and methods of using the same to detect the presence of a thrombus within said filter devices. A device of the present disclosure for detecting a thrombus or other blood particulate matter of a threshold size within a vessel can comprise a filter having a head and a plurality of legs extending distally therefrom, configured to capture the thrombus or other blood particulate matter of at least a threshold size, and at least one impedance element positioned distal to the head and configured to detect a presence of the thrombus or other blood particulate matter of at least a threshold size within the filter by obtaining data within a bloodstream when the filter is positioned within the bloodstream..
3dt Holdings, Llc

Spiral electrode for neuromodulation therapy

Catheters having spiral electrodes and methods for their use in neuromodulation therapy. A therapeutic assembly is disposed at a distal portion of a neuromodulation catheter and is adapted to be located at a target location within a target blood vessel of a human patient.
Medtronic Ardian Luxembourg S.a.r.l.

Methods for facilitating revascularization of occlusion

This patent document discloses methods for facilitating revascularization of an occlusion in a blood vessel. A method can include engaging a first guide within a vessel wall adjacent to a distal cap of the occlusion and advancing the first guide, in a retrograde direction, to a subintimal position near a proximal cap of the occlusion.
Vascular Solutions, Inc.

Skin tag removal assembly

A skin tag removal assembly for non surgical remove of skin tags includes a pair of straws. A string is extended through each of the straws.

Blood vessel analysis device and operating method thereof

A blood vessel analysis device includes a photoelectric detector, a processor and an ultrasonic detector. The photoelectric detector detects a blood vessel and generates a detecting signal.
National Kaohsiung University Of Applied Sciences

Combined mimo array and phased array for blood velocity detection

A system includes at least one piezoelectric transducer array having a plurality of piezoelectric transducer elements. The transducer array is configured to be placed on an area of skin.
Robert Bosch Gmbh

Micro-mechanical adjustment system for piezoelectric transducers

A system for detecting blood velocity within a blood vessel includes a transducer array including a plurality of transducers. Each of the transducers includes a carrier substrate; at least one spacer extending upwardly from substrate, a transducer element attached to spacer such that the piezoelectric transducer is spaced apart from the substrate, and setting electrodes positioned on the upper surface of the substrate under the piezoelectric transducer.
Robert Bosch Gmbh

Phased array for detecting artery location to measure blood velocity

A system for detecting artery location to measure blood velocity includes a first piezoelectric transducer array including a plurality of transducer elements, each of the transducer elements being supported on a first ceramic substrate, the first ceramic substrate having a planar lower surface configured to be placed on a surface of an area of skin of a user, the first ceramic substrate being configured to couple an ultrasonic signal emitted by the transducer elements to the skin. A phase control system is configured to supply each of the transducer elements with an electrical actuation signal, the electrical actuation signal being phase shifted for each of the transducer elements.
Robert Bosch Gmbh

Single piezoelectric transmitter and receiver to detect blood velocities

A system for detecting blood velocity within a blood vessel includes a piezoelectric transducer supported on a ceramic substrate. The ceramic substrate supports the piezoelectric transducer at a fixed angle of incidence that is greater than 0° and less than 90°.
Robert Bosch Gmbh

Medical information processing apparatus and medical information processing method

A medical information processing apparatus according to an embodiment includes processing circuitry. The processing circuitry acquires a first index value obtained based on fluid analysis that is performed based on an image including a blood vessel of a subject, the first index value being related to blood flow at each of positions in the blood vessel.
Toshiba Medical Systems Corporation

Medical information processing apparatus, x-ray ct apparatus, and medical information processing method

A medical information processing apparatus according to an embodiment includes processing circuitry. The processing circuitry obtains image data rendering a blood vessel of patient.
Toshiba Medical Systems Corporation

Illumination optics for a visible or infrared based viewing or imaging blood vessels

Synchronously with respect to camera frames or through user selection, switching on and off light sources which has the effect of 1) dynamically changing the overall angular distribution of light thus changing surface level reflectance; 2) revealing and through processing removing unwanted patterning caused by optical defects or contaminants on optical surfaces or surface hair; 3) moving illumination patterns to permit contrast enhancement in all areas of the surface.. .

Pulse photometer

A pulse photometer includes a light emitter, a light detector, a first signal separator that separates a first signal component and a first noise component, a second signal separator that separates a second signal component and a second noise component, a first determining section, a second determining section, and a concentration calculating section that calculates a concentration of a light absorption material in blood of the subject based on a fundamental frequency of the first signal component or a fundamental frequency of the second signal component.. .
Nihon Kohden Corporation

Insulin pump based expert system

An apparatus comprising a pump configured to deliver insulin, an input configured to receive blood glucose data, a user interface, and a controller communicatively coupled to the pump, the input, and the user interface. The controller includes a blood glucose data module to compare the blood glucose data to a target blood glucose level for an insulin pump user.
Tandem Diabetes Care, Inc.

Systems and methods for determining an abnormal glycemic event using surrogates for glucose

Systems and methods for determining an abnormal glycemic event using surrogates for glucose are disclosed herein. In an embodiment, a medical system includes a medical device associated with a subject and a processor communicatively coupled to the medical device.
Cardiac Pacemakers, Inc.

Wearable and unobtrusive multi-sensor array and pulse wave velocity imaging

Novel and advantageous systems, devices, and methods for pulse wave velocity (pwv) imaging that enable precise central blood pressure (bp) estimation are provided. A multi-sensor array can provide two-dimensional pwv, thereby achieving the pwv imaging and precise central bp estimation.
The Chinese University Of Hong Kong

Improvements in or relating to measurement of blood pressure

Disclosed is a blood pressure measurement device comprising a heat flow perfusion sensor in combination with occlusion means for restricting the flow of blood in a portion of a human or animal body.. .
Epitherm Limited

Biological signal processing device and blood pressure measurement system

An r-wave of a heartbeat signal accompanied by periodic fluctuation is detected to obtain the average value of an rr interval. Further, a waveform of a heart sound signal, which periodically fluctuates in synchronization with the heartbeat signal, is forcibly repositioned at an interval equivalent to the average value of the rr interval.
Ai Technology Inc.

Methods, systems and devices for measuring heart rate

A system and method of tracking activity includes a motion sensor, a light source and a light detector. The light detector is configured to capture an amount of the light that is reflected back to the light detector, at least a first portion of the light reflected back to the light detector is reflected from a blood vessel disposed under a skin adjacent to the housing.
Fitbit, Inc.

Blood pressure apparatus using active materials and related methods

Example blood pressure apparatus using active materials and related methods are described herein. An example apparatus includes a band to be worn around a limb of a user, an active material carried by the band and a controller to: (1) apply an activation signal to the active material to constrict blood flow in the limb, and (2) reduce the activation signal to allow blood flow in the limb..

System and angiography

The system comprises an optical fiber, a light emitting module, an ultrasound detector and an imaging system. The optical fiber has a first end and a second end.
Metal Industries Research & Development Centre

Blood pressure and cardiac monitoring system and method thereof

A blood pressure and cardiac monitoring system includes a sensing assembly, a processor, a memory, a communication interface, and any suitable computer implemented modules communicatively coupled to each other via a bus. The sensing assembly comprises of a first sensor (single or multi-axes) located at a first axis of a target generating a first time-dependent motion waveform representative of one or more contractile properties of the target's heart and a second sensor (single or multi-axes) located at a second axis of the target generating a second time dependent motion waveform representative of the target's blood flow.
Robert Bosch Gmbh

Method for preparing organic coating porous granules for fish feed or assorted feed aid using blood of livestock and clay minerals

The present invention relates to a method for preparing granules for a fish feed or an assorted feed aid, and more particularly, a method for preparing organic coating porous granules for a fish feed or an assorted feed aid using the blood of livestock and clay minerals. The present invention is to provide granules for a fish feed or an assorted feed aid, wherein the granule contains useful minerals, such as zeolite and bentonite, suitable to be used for a feed, and includes an organic coating layer mainly composed of proteins formed on a surface of the granule by using the blood (let blood) of livestock, so that the time while water infiltrates into pores inside the granule mainly composed of inorganic substances is delayed, thereby obtaining having excellent fluidity..
Macsumsuk General Medical Co., Ltd.

System and luring and trapping blood-seeking and biting insects including hematophagous arthropods

A system, and method for trapping biting or blood-seeking flying insects, including a host-seeking stage module configured to trap target insects in a host-seeking stage thereof, and comprising a lure including an olfactory cue configured to attract the target-insects in the host-seeking stage, and a first suction mechanism configured with suction to suck the target insects in the host-seeking stage near the lure into a first container; and a ovipository stage module configured to trap target insects in an ovipository stage thereof, and comprising a water reservoir configured to attract gravid females seeking to deposit eggs thereon, and a second suction mechanism configured with suction to suck the gravid females from the water reservoir into a second container.. .

Medical image processing methods and systems

A medical image processing method of determining a fractional flow reserve through a stenosis of a coronary artery from medical image data is disclosed. The medical image data comprises a set of images of a coronary region of a patient.
Singapore Health Services Pte Ltd

Method to recalibrate continuous glucose monitoring data on-line

In a method of recalibrating continuous glucose monitoring data from a user, operable on a digital processor, an indication from the user that the user has taken a meal is received (806). A self-monitored of blood glucose levels from the user (810) at two separate times during a day corresponding to when the user has taken a meal.
Universita Degli Studi Di Padova

Systems and methods for embolism prediction using embolus source and destination probabilities

Systems and methods are disclosed for determining a patient risk assessment or treatment plan based on emboli dislodgement and destination. One method includes receiving a patient-specific anatomic model generated from patient-specific imaging of at least a portion of a patient's vasculature; determining or receiving a location of interest in the patient-specific anatomic model of the patient's vasculature; using a computing processor for calculating blood flow through the patient-specific anatomic model to determine blood flow characteristics through at least the portion of the patient's vasculature of the patient-specific anatomic model downstream from the location of interest; and using a computing processor for particle tracking through the simulated blood flow to determine a destination probability of an embolus originating from the location of interest in the patient-specific anatomic model, based on the determined blood flow characteristics..
Heartflow, Inc.

Assays for detecting the presence or amount of an anti-drug antibody

Methods and kits for detecting antibodies (e.g., anti-drug antibodies). Such methods and kits permit the detection of, for example, anti-drug antibodies in human body fluids, such as blood, plasma and serum..
Genzyme Corporation

Method of differentiating stable angina pectoris from acute coronary syndrome and diagnostic kit thereof

This application discloses a method of differentiating stable angina pectoris from acute coronary syndrome, including: obtaining a blood plasma sample from a patient; measuring a relative concentration of at least one metabolic biomarker in the blood plasma sample, wherein the at least one metabolic biomarker is selected from the group consisting of malic acid, taurine, arachidonic acid, citramalic acid, methionine, and pentadecanoic acid; calculating a value according to the relative concentration of at least one metabolic biomarker; comparing the value with a predefined critical value, if the value is more than the predefined critical value, the patient has the acute coronary syndrome, otherwise, the patient has the stable angina pectoris. The method and a diagnostic kit thereof is capable of differential diagnosis of sa and acs and it can improve the diagnostic convenience and promote the diagnostic standardization..

Micro-array devices for capturing cells in blood and methods of their use

The present disclosure provides micro-array devices for capturing cells in blood and methods of their use. In some aspects, a method for counting cells in a blood sample is provided, the method comprising applying a blood sample onto a cnt device; allowing cells in the blood sample to differentially settle on the cnt device, and identifying and counting cells of preselected type in the blood sample..
University Of Louisville Research Foundation, Inc.

Blood sample testing apparatus and blood sample testing method

A blood sample testing apparatus may include: a blood-cell-count measurement unit that performs measurement of a blood sample stored in a sample container positioned in a first position; a smear preparation unit that prepares a smear of the blood sample stored in the sample container positioned in a second position; and a transport unit that transports the sample container from the first position to the second position and from the second position to the first position.. .
Sysmex Corporation

Apparatus and methods for managing blood pressure vital sign content in an electronic anesthesia record

A graphical user interface and methods for managing blood pressure vital sign content in an electronic anesthesia record on a multi-function gesture-sensitive device via gesture-based means. The graphical user interface and methods give an improved user interface and set of functions via novel functions unique to gesture sensitive interfaces..

Method for determining genetic condition of fetus

Provided is a method for determining a genetic condition of a fetus, the method including: an objective region selection step of selecting an objective region for determining the genetic condition, from regions on a human genome; a step of isolating a single cell from a maternal blood sample; a step of extracting genomic dna from the single cell; a step of performing pcr amplification on the objective region using a primer set designed so as to perform the pcr amplification on the objective region using genomic dna extracted from the single cell as a template; and a dna sequencing step of decoding a dna base sequence of a pcr amplification product of the objective region, in which the primer set designed so as to perform the pcr amplification on the objective region is designed through a method for designing a primer set used for the polymerase chain reaction, the method for designing a primer set including a first stage selection step based on a local alignment score and a second stage selection step based on a global alignment score.. .
Fujifilm Corporation

Determining antigen-specific t-cells

The invention is directed to methods for determining antigen-specific t cells. In some embodiments, methods of the invention may be implemented by the steps of reacting under interaction conditions one or more antigens with t cells in a plurality of subsets of a tissue sample, such as peripheral blood; sorting antigen-interacting t cells from other t cells; separately sequencing for each subset recombined nucleic acid encoding a segment of a tcr chain from a sample of t cells prior to exposure to antigen and from a sample of t cells isolated based on their interaction with antigen, thereby forming a clonotype profile for the former sample and the latter sample for each subset; and identifying as antigen-specific t cells those t cells associated with a clonotype whose frequency increases in the latter sample relative to its frequency in the former sample..
Adaptive Biotechnologies Corp.

Maximizing dna yield of blood specimens collected in rapid clot tubes

The invention provides methods for isolating dna from a blood sample collected into tubes containing a rapid clot activator, which involves the use of a lysis buffer comprising an alcohol.. .
Abbott Molecular Inc.

Method of extraction of genomic dna for molecular diagnostics and application

Methods and systems for extracting dna from a sample are provided. A method includes: lysing red blood cells of the sample using a first solution; dissolving lipids of cellular membranes in the sample using a second solution; and releasing dna of the sample into a buffer using a third solution..
Pzm Diagnostics, Llc

Measurement unbound bilirubin in blood sample

Provided is a measurement method whereby the amount of unbound bilirubin (ub) can be exactly reflected whether a specimen contains a large amount of conjugated bilirubin or not. The measurement method for ub according to the present invention comprises decomposition step (i), decomposition stopping step (ii), contact step (iii) and detection step (iv).
National University Corporation Kobe University

Centrifuge and segment holder

A centrifuge (70) is provided with a cup (80) configured to house a blood bag system (10a) and centrifugally separates blood in the blood bag system (10a) by rotating the cup (80). The cup (80) has a segment holding section (86) capable of holding a plurality of segment tubes (44a), aligned in a parallel state by being folded at a sealing portion (44b) of an outlet-side tube (44), along a direction in which a centrifugal force acts during centrifugal processing or a direction inclined with respect to the direction in which the centrifugal force acts..
Terumo Kabushiki Kaisha

Hollow fiber membrane blood purifying device

A hollow fiber membrane blood purifying device including a cylindrical container, a hollow fiber membrane bundle, a potting resin fixing portion embedding and fixing the hollow fiber membrane bundle at each end of the cylindrical container, headers having nozzles, and ports further has the structure in which each header and the cylindrical container are welded in at least two regions over the circumference. The inside face of the header is in contact with a potting resin fixing portion cut face that is formed by cutting an outer side portion of the potting resin fixing portion in the length direction of the cylindrical container than the end face of each end of the cylindrical container, and the potting resin fixing portion cut face is in a compressively deformed state..
Asahi Kasei Medical Co., Ltd.

Method for controlling flow in a bodily organ

A method for treating a male impotent patient, the method comprising the steps of cutting the skin of the patient, inserting a dissecting tool and dissecting an area of at least one portion of a tissue wall of a penile portion, and placing a medical device. The medical device comprises a constriction device configured to gently constrict the penile portion to restrict the blood flow leaving the penis, and a stimulation device configured to stimulate the penile portion constricted by the constriction device to at least further restrict the blood flow leaving the penis to achieve erection..

Medicine injection and disease management systems, devices, and methods

One or more embodiments of the present disclosure may include an insulin delivery system that includes an insulin delivery device, a user interface that includes multiple user-selectable icons or buttons each representing different meal characteristics, memory to store one or more user-specific dosage parameter, and a processor in communication with the memory and adapted to receive blood glucose data. The processor may also be adapted to determine initial meal characteristics associated with each of the user-selectable icons or buttons based on at least one of the user-specific dosage parameters.
Bigfoot Biomedical, Inc.

Dual lumen cannula

A dual lumen coaxial cannula assembly includes a first infusion tube having a first elongate body defining a first lumen therethrough and a second drainage tube co-axially aligned with the first infusion tube and having a second elongate body with a second lumen defined by a space between the first infusion tube and second drainage tube. A connector is removably attached to the first infusion tube and the second drainage tube for coupling the dual lumen coaxial cannula to an extracorporeal blood circuit.
Cardiacassist, Inc.

Filtering a pressure signal from a pressure sensor in a blood processing apparatus

A signal filtering device acquires a pressure signal from a pressure sensor in a blood processing apparatus having a known disturbance generator that generates a disturbance in the pressure signal. The signal filtering device obtains (401) a current set of principal components representing the disturbance.
Gambro Lundia Ab

Method and premixing dialysate

An apparatus for premixing fluids to form dialysate for an extracorporeal blood treatment includes at least a first feed portion for supplying at least a first fluid from at least a first fluid reservoir, at least a second feed portion for supplying at least a second fluid from at least a second fluid reservoir, a premixing portion being configured to premix fluids supplied via the feed portions in counter flow to form a fluid mixture and at least one drain portion for draining the fluid mixture premixed in the premixing portion as dialysate. A method carries out appropriate steps.
B. Braun Avitum Ag

Heart pump driveline power modulation

Systems and method for powering an implanted blood pump are disclosed herein. The system can be a mechanical circulatory support system.
Tc1 Llc

Field-oriented control for control of blood pump motor

A ventricular assist device includes a pump configured to pump blood of a patient. A motor is configured to operate the pump.
Heartware, Inc.

Blood pump with sensors on housing surface

A blood pump has an inner housing and an actuator at least partially surrounded by the inner housing which is configured to drive a flow of blood within the body. An electronic component associated with a surface of the housing includes one or more thin film active electronic devices which implement one or more transducers configured to generate a signal based on movement associated with operation of the blood pump.
Heartware, Inc.

Hemostatic injection needle coated with crosslinked chitosan having catechol group and oxidized catechol group

The present invention relates to a hemostatic injection needle coated with a chitosan in which a catechol group and an oxidized catechol group are introduced and cross-linked. The hemostatic injection needle according to the present invention can suppress bleeding during and after injection, and thus can be effectively used for injection not only into coagulopathy patients, including diabetic patients, patients under anticancer treatment, and haemophilia patients, who have a low hemostatic ability, but also into patients showing blood rejection responses, and children..
Innotherapy Inc.

Anti-obesity composition comprising pine needle juice powder as effective component

An anti-obesity composition comprises pine needle juice powder as an effective component. Because it is found that, not only a significantly higher extraction yield is obtained and a higher inhibitory activity on differentiation of an adipocyte is obtained when an extract is produced by using pine needle juice powder obtained by juicing process instead of using dry pine needle which has not been treated with any juicing process, but also both the body weight and weight of white adipose tissues are lowered and content of total lipid, total cholesterol, and triglyceride in blood is significantly lowered according to oral administration of the pine needle juice powder of the present invention to a model mouse under high fat diet, the pine needle juice powder of the present invention can be more advantageously used for a pharmaceutical composition or a functional health food for prophylaxis or treatment of obesity..
Industry-academic Cooperation Foundation, Chosun University

Compositions and methods for providing hematopoietic function without hla matching

The present invention relates to methods and compositions for providing hematopoietic function in immunodeficient human patients, by selecting an expanded human umbilical cord blood stem/progenitor cell sample without taking into account the hla-type of the expanded human cord blood stem/progenitor sample or the hla-type of the patient; and administering the selected expanded human cord blood stem/progenitor cell sample to the patient. Methods for obtaining the expanded human cord blood stem/progenitor cell samples, banks of frozen expanded human cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein..
Fred Hutchinson Cancer Research Center

Methods of monitoring estriol therapy

Provided are methods for treating a neurodegenerative disease, such as multiple sclerosis, in a subject receiving a first estriol treatment regimen, comprising obtaining a measurement of the serum estriol concentration in the blood of the subject, and administering a second estriol treatment regimen to the subject if the serum estriol concentration is less than 6 ng/ml. The daily amount of estriol administered during the second estriol treatment regimen is preferably greater than the daily amount of estriol administered during the first estriol treatment regimen..
The Regents Of The University Of California

Targeted liposomal delivery of cgmp analogues

The invention relates to means and methods of targeted drug delivery of therapeutic agent to and across the blood-ocular barrier. In particular, the invention relates to cyclic guanosine-3′,5 ‘-monophosphate analogues as therapeutic agent for treating retinal diseases.
Mireca Medicines Gmbh

Valve replacement using rotational anchors

Features for a heart valve device are described. The device may include a frame with anchors configured to secure the device to tissue.
Millipede, Inc.

Stent planning systems and methods using vessel representation

In part, the disclosure relates to determining a stent deployment location and other parameters using blood vessel data. Stent deployment can be planned such that the amount of blood flow restored from stenting relative to an unstented vessel increases one or more metrics.
Lightlab Imaging, Inc.

Multi-electrode catheter assemblies for renal neuromodulation and associated systems and methods

Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel.
Medtronic Ardian Luxembourg S.a.r.l.

Artery medical apparatus and methods of use thereof

Methods and medical apparatus for deployment within an anatomical blood vessel. The medical apparatuses comprising: a first tubular wall, a second tubular wall, within the first tubular wall, and a constricting element configured to constrict a circumference of a portion of the second tubular wall; the combination of the first tubular wall, the second tubular wall and the constricting element forms a diametrical reducer..
Restore Medical Ltd

Blood flow reducer and method using the same

A blood flow reducer (20) for insertion in a blood vessel, the reducer (20) being adapted to be deformed from a first configuration to an expanded configuration, wherein, in the expanded configuration, the reducer (20) defines an axial lumen (40) for allowing blood flow therethrough, the axial lumen (40) having a smallest cross-section, the reducer (20) has a largest cross-section, and the smallest cross-section is comprised between 20% and 90% of the largest cross-section. In particular, the smallest cross-section is strictly comprised between 70% and 90% of the largest cross-section.
Institut National De La SantÉ Et De La Recherche MÉdicale

Apparatus for controlling flow in a bodily organ

A flow control apparatus for controlling a flow of fluid and/or other matter in a lumen formed by a tissue wall of a patient's organ. The apparatus comprises a control device adapted to control contraction of the tissue wall to influence the flow in the lumen.

Large bore vascular closure system

A vascular closure system for sealing an opening in a blood vessel may include an introducer sheath extending through the opening, the introducer sheath having a lumen extending through the introducer sheath, wherein partial withdrawal of the introducer sheath from the opening everts tissue of the blood vessel at the opening, and a shaping sheath slidably disposed over the introducer sheath, the shaping sheath having a split distal portion configured to engage the everted tissue.. .
Boston Scientific Scimed, Inc.

Bodily emission analysis

Apparatus and methods are described for use with a bodily emission (26) of a subject that is disposed within a toilet bowl. While the bodily emission is disposed within the toilet bowl (23), light is received from the toilet bowl using one or more light sensors (60).
Outsense Diagnostics Ltd.

Ultrasonic diagnostic apparatus

An ultrasonic diagnostic apparatus, including a transceiver for sequentially generating multiple received signals, a color flow mapping signal processing unit that generates blood flow velocity data based on the multiple received signals, and a residual image processing unit that includes an aliasing determination unit and a persistence calculation unit and performs residual image processing on blood flow velocity data, an aliasing determination unit that adds the blood flow velocity data vcurrent for the most recent frame and the blood flow velocity data vout-1 for the frame preceding the most recent frame, performs aliasing determination on the frame that was determined by a frame before the most recent frame based on the aliasing determination results of the blood flow velocity data, and a persistence calculation unit that performs a persistence calculation after performing a correction to the blood flow velocity data in which aliasing has occurred.. .
Konica Minolta, Inc.

Systems and methods for image processing to determine blood flow

Systems and methods are disclosed for assessing a risk of disease. One method includes obtaining an anatomic model associated with a target anatomy; modeling, using a processor, an injection of one or more virtual contrast agents into the anatomic model; performing a simulation of flow of blood and the one or more virtual contrast agents through the anatomic model; and computing one or more characteristics of concentration associated with the one or more virtual contrast agents at one or more locations in the anatomic model based on the simulation..
Heartflow, Inc.

Smart wearable device for health watch

A wearable device comprising a display dial configured to display various health parameters, a wristband assisting the device to wear on wrist, an eject-able tray comprising a micro-chip, a first spring coupled to the eject-able tray, at least one latch provided with a second spring to hold the eject-able tray within the device by compressing the first spring, and a health monitoring unit provided with multiple sensors to determine various health parameters, wherein compression of the second spring results in the latch to release the eject-able tray which in turn relaxes the compressed first spring to eject the micro-chip outside the device for collecting blood samples. The microchip comprises at least one micro-needle and an enzyme test strip for collecting and analyzing the blood samples.
Sensesemi Technologies Private Limited

Real time modeling of analyte transport in a medium surrounding an implanted sensor to calculate a corresponding concentration of analyte in a distant medium

An analyte monitoring system and method. The analyte monitoring system may include an analyte sensor and a transceiver.
Senseonics, Incorporated

Detecting apparatus based on image for blood glucose concentration and method thereof

The present invention provides a detecting apparatus based on image for detecting blood glucose concentration and method thereof. The detecting apparatus comprising a lighting device, an image capture device, a thermal imager and an operating device.
National Applied Research Laboratories

System and magnetic resonance angiography using hyperpolarized fluid

Systems and methods are provided for performing a medical imaging. The system includes a main magnet system configured to generate a main static magnetic field about at least a region of interest (rod of a subject arranged in the main magnet system.
The General Hospital Corporation

System and physiological parameter monitoring

A device (110), method and system (100) for calculating, estimating, or monitoring the blood pressure of a subject are disclosed. A first signal representing heart activity of a subject may be received.
Vita-course Technologies Co., Ltd.

System and blood pressure monitoring

A device (110), method and system (100) for calculating, estimating, or monitoring the blood pressure of a subject. At least one processor, when executing instructions, may perform one or more of the following operations.
Vita-course Technologies Co., Ltd.

Monitoring device and operating the same

A device for radiating pulsed light toward a thrombus in a blood vessel includes a light source configured to output monitoring light to be radiated into the blood vessel, a light detector configured to detect returned light of the monitoring light and output a detection signal, and a computer configured to acquire a time waveform, which is a change in an intensity of the returned light over time, based on the detection signal, wherein the computer is configured to obtain a parameter on the basis of the time waveform and evaluates a reaction in the blood vessel according to the radiation of the pulsed light on the basis of the parameter.. .
Hamamatsu Photonics K.k.

Instrumented toilet seat

A toilet seat with handles is disclosed. The handles include light transmitters and light receivers.

Method and device for producing electromagnetic fields that influence the nervous system of insects

The invention relates to a method and to a device for repelling insects by means of a two-channel pulse pattern transmitter (1), which, by means of the integrated antennas (34a, 34b), emits two electromagnetic waves (35a, 36a) phase-shifted against each other by 180 degrees and modulated and pulsed with the pulse patterns (24, 23) and produces two electromagnetic fields (35b, 36b), which act on insects (45) located in the radiation range (76) in such a way that the neurons (50, 53) located in the supraesophageal and subesophageal ganglia (48, 51) and the sensory neurons (65), the motor neurons (66), and the interneurons that exist in the central and peripheral nervous system (63, 64) of bloodsucking insects (45) are influenced in such a way that the signals and reflexes produced by the neurons trigger abnormal behaviors that put the insects into an inactive state such that bloodsucking insects cannot penetrate the skin of humans and thus cannot suck blood.. .

Method and system for registering ultrasound and computed tomography images

A method for registering ultrasound (us) and computed tomography (ct) images, comprising: receiving us and ct images representative of a body portion comprising blood vessels and an initial approximate transform; enhancing the blood vessels in the us and ct images, thereby obtaining an enhanced us and ct images; creating a point-set for a given one of the enhanced us and ct images; determining a final transform between the point-set and the other one of the enhanced us and ct images using the initial transform; applying the final transform to a given one of the us and ct images to align together a coordinate system of the us image and a coordinate system of the ct image, thereby obtaining a transformed image; and outputting the transformed image.. .
The University Of Western Ontario

Device for providing health information and advice to shoppers

A product assistant device may attach to a shopping cart or other baggage cart and provide information and guidance on products within a retail space. The assistant device may provide physiological information from sensors such as heart rate, blood pressure, or other non-invasively measured characteristics via a display.
Ach Food Companies, Inc.

System for laboratory values automated analysis and risk notification in intensive care unit

In a risk level assessment method for a plurality of clinical conditions as follows, a set of laboratory test results (32) are stored with time stamps for a patient, including at least one hematology test result and at least one arterial blood gas (abg) test result. For each clinical condition, a risk level is determined for the clinical condition based on a clinical condition-specific sub-set of the stored set of laboratory test results.
Koninklijke Philips N.v.

Automatic analysis device and automatic analysis method

The automatic analysis device 100 is provided with: a specimen dispensing mechanism 101 that dispenses subject blood plasma and/or normal blood plasma to be added to correct the coagulation time of the subject blood plasma, into a plurality of specimen containers 103; reaction containers 104 that contain the subject blood plasma and/or the normal blood plasma; a reagent dispensing mechanism 106 that dispenses a reagent into the reaction containers 104; and a detecting unit 113 which applies light from a light source 115 to the subject blood plasma and/or the normal blood plasma to which the reagent is added in the reaction containers 104, and which measures the coagulation time on the basis of the obtained scattered light and/or transmitted light.. .
Hitachi High-technologies Corporation

Method for diagnosing diseases through oligomer analysis of abnormally aggregated proteins

The present invention relates to a method for diagnosing a disease using an analysis of oligomer of an abnormal aggregated protein includes: (1) preparing a body fluid sample including at least one of blood, blood plasma, blood serum, saliva, urine, tear, and mucus; (2) making a dilution of the body fluid sample; (3) using a biosensor to measure and detect an aggregated protein in the diluted body fluid sample; (4) analyzing a signal change of the biosensor caused by the dilution of the aggregated protein to determine a slope according to the dilution from the measurements; and (5) analyzing a proportion of the oligomer from the slope according to the dilution to make a diagnosis. The method uses a biosensor to measure the impedance and the protein concentration of blood and detects the slope according to the numerical value of the monomer and the oligomer to diagnose normal or abnormal protein aggregation or the associated diseases with more accuracy..
Korea Institute Of Science And Technology

Biomarker for diagnosis of extrahepatic bile duct carcinoma, intrahepatic bile duct carcinoma, or gallbladder carcinoma

When the concentration of ceacam1 in a blood sample collected from a test subject is detected using a kit for diagnosis comprising an antibody specifically binding to ceacam1 or a labeled product thereof, or the like and the ceacam1 concentration is higher than the concentration of ceacam1 in a blood sample derived from a non-carcinoma control subject or higher than a certain threshold value (cutoff value), data can be collected for diagnosing the test subject as having a high possibility of having extrahepatic bile duct carcinoma, intrahepatic bile duct carcinoma, or gallbladder carcinoma.. .

Electrical characteristic measurement device, electrical characteristic measurement method, blood condition analysis system, and electrical characteristic measurement program for causing computer to execute the method

A technology of measuring an electrical characteristic of a blood sample is provided that allows easy introduction, into an existing blood test system, a technique of obtaining information on a blood sample from an electrical characteristic of the blood sample. The technology provides a device for measuring an electrical characteristic of a blood sample, the device including: a mixing unit configured to mix a blood cell component and a plasma component on the basis of the composition ratio between the blood cell component and the plasma component in a blood sample; and a blood sample measurement unit configured to measure an electrical characteristic of a blood sample obtained by mixing by the mixing unit..
Sony Corporation

Analyte determination method and analyte meter

The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip..
Agamatrix, Inc.

Fish panel for ctcl

Described herein are probes useful to detect gene copy number alterations of genes characteristic/indicative of cutaneous t cell lymphoma (ctcl), such as ctcl with blood involvement, including probes specific to genes amplified or deleted in cutaneous t cell lymphoma (ctcl), such as ctcl with blood involvement; methods of detecting a (one or more) genetic abnormality, such as one or more gene copy number alteration (gcna), characteristic/indicative of cutaneous t cell lymphoma (ctcl), such as ctcl with blood involvement, in a biological sample obtained from an individual; and methods of determining if an individual has cutaneous t cell lymphoma (ctcl), such as ctcl with blood involvement, or is likely to develop cutaneous t cell lymphoma (ctcl) with blood involvement.. .
Yale University

Cell culture medium

The present invention relates to a cell culture medium for culturing human cells comprising an anti-coagulated total blood material wherein the hemoglobin level is from about 8 to about 16 g/dl. More particularly, the invention provides a cell culture medium in which cells present in the blood are disrupted and the insoluble remnants of the lysated cells are removed.
Biomarker Ltd.

Process of separating blood plasma/serum from whole blood

The invention relates to whole blood filter media and a process of filtering whole blood samples using a filter medium comprising particles, wherein the blood cells are retained inside the filter, and wherein the plasma or serum is separated from the blood cells.. .
Mann+hummel Gmbh

System and platelet removal during mononuclear cell collection

A method of collecting mononuclear cells, comprising separating whole blood into cellular components and platelets suspended in plasma, separating the platelets suspended in plasma into platelet concentrate and platelet-poor plasma, combining the cellular components with the platelet-poor plasma to form a first mixture, and separating the first mixture into mononuclear cells and at least one component.. .
Fenwal, Inc.

Cannula device, artificial lung

A cannula device for the circulation of the blood in an artificial lung, includes: an aspiration lumen including at least one orifice permitting the aspiration of a volume of blood; an injection lumen including at least one orifice permitting the injection of a volume of blood, wherein the injection lumen and the aspiration lumen are held rigidly connected over at least a portion of their length, the lumens being sealed in relation to each other, the injection lumen having a deformable element, which is held on a portion of the distal end thereof, the deformable element having a first setting and a second setting, the change from the first setting to the second setting being effected by a modification of the diameter of the deformable element.. .
Centre Chirurgical Marie Lannelongue

Vascular access system with connector

A connector for fluidly coupling proximal and distal tubular segments of a fluid conduit is provided. In one embodiment, a system is provided for providing continuous flow of blood between two locations in a patient's cardiovascular system.
Merit Medical Systems, Inc.

Devices and methods for extracorporeal conditioning of blood

The disclosure relates to devices and methods for extracorporeal conditioning of blood. Extracorporeal blood oxygenators and blood oxygenator components, such as conditioning modules, are described.

Disposable fluid circuits for extracorporeal photopheresis with integrated source of photoactive agent

Disposable fluid circuits, systems utilizing disposable fluid circuits and methods for combining a treating agent with separated blood component are disclosed. The treating agent is contained within a container and the disposable fluid circuit includes one or more frangible cannulas located in one or more flow paths of the circuit that are selectively opened to establish flow communication between the treating agent container and a treatment container, and/or a separation chamber or other container..
Fenwal, Inc.

System for peritoneal dialysis and extracorporeal blood treatments

A dialysis system is configured to enable a patient to undergo both peritoneal dialysis and extracorporeal blood treatments. The example dialysis system includes a base unit configurable to provide a first fluid for use in preforming at least one peritoneal dialysis treatment at a first time.
Baxter Healthcare Sa

Physiologically responsive vad

A ventricular assist device incorporating a rotary pump, such as a rotary impeller pump is implantable in fluid communication with a ventricle and an artery to assist blood flow from the ventricle to the artery. The device includes a pump drive circuit supplying power to the pump, one or more sensors for sensing one or more electrophysiological signals such as electrogram signals in and a signal processing circuit connected to the sensors and the pump drive circuit.
Heartware, Inc.

Cannula system with sterile connector, blood pump, and patient harness

A system for assisting a patient's heart has a pump, an oxygenator, a holder having a pump receiving portion for removably receiving the pump and an oxygenator receiving portion for removably receiving the oxygenator, and a harness configured to surround at least a portion of a patient's torso. The holder is connected to the harness.
Cardiac Assist, Inc.

Dietary supplements containing dehydrated strawberry

Compositions and processes are disclosed for a capsule, tablet, or pill comprised of powdered strawberries. Fresh strawberries are washed, de-calyxed, and then processed into a dry pulp.

Systems and methods for deriving and collecting platelet products

Systems and methods are provided for deriving a platelet product from a plurality of buffy coats. A plurality of buffy coats are separately collected, for example, using a conventional floor centrifuge.
Fenwal, Inc.

Medicinal agent and beverage/food for preventing cerebral dysfunction and improvidng same

Provided is method for improving depression of a patient by administering to a patient suffering from depression an effective dose of sepiapterin or a pharmaceutically acceptable salt of sepiapterin in an amount from 0.1 to 100 mg/kg of body weight per day. The sepiapterin or salt of sepiapterin entering the patient's bloodstream and passing the patient's blood-brain barrier to enter a neuron, and the sepiapterin or salt of sepiapterin converting to tetrahydrobiopterin in a neuron of the brain and the tetrahydrobiopterin facilitating biosynthesis of an aromatic monoamine in the patient's brain to provide an elevated level of an aromatic monoamine in the patient's brain to improve depression of the patient.

Methods for treating hemolytic diseases and sickle cell disease

The present disclosure generally relates to methods of treating hemolytic diseases such as sickle cell anemia using kinase inhibitors, for example, compounds that inhibit the spleen tyrosine kinase (syk). In some embodiments a method is presented to prevent thrombosis in blood vessels of patients with a hemolytic disease comprising the step of: administrating to a patient having at least one hemolytic disease a therapeutically effective amount of at least one syk inhibitor.
Purdue Research Foundation Office Of Technology Commercialization

Systemic treatment of blood-sucking and blood-consuming parasites by oral administration of a parasiticidal agent

Pharmaceutically acceptable single parasiticidal agent compositions of imidacloprid for oral delivery to mammals to systemically control targeted blood-sucking or blood-consuming parasites, such as fleas, ticks and certain species of helminthes and scabies.. .
Bayer Healthcare Llc

Sterile container comprising sterile barrier separate from primary package and manufacturing sterile container

A sterile container including at least one hollow fiber filter module, especially dialyzer, which is accommodated in a hermetically sealed holding volume of a primary package and includes a blood compartment delimited by a blood inlet opening and a blood outlet opening, wherein a plurality of hollow fiber filter modules is arranged in the primary package and the sterile barrier of the blood compartment of each hollow fiber filter module inside the primary package is implemented by caps which close the blood inlet opening and the blood outlet opening of each hollow fiber filter module. A method of manufacturing such sterile container is also disclosed..
B. Braun Avitum Ag

Device and increasing flow through the left atrial appendage

Methods and devices for increasing flow in the left atrial appendage (laa) include a conduit directing blood flow from a pulmonary artery into the laa and/or a conduit drawing blood from the laa by a bernoulli effect. In one embodiment, a method comprises implanting a conduit in a pulmonary vein, expanding an inlet portion such that the conduit becomes anchored within the vein and directs blood through an outlet portion of the conduit into or toward the left atrial appendage..
Edwards Lifesciences Corporation

Prosthetic heart valve

A prosthetic heart valve includes a valve frame (2), on which a plurality of valve leaflets (8) are fixed, and a fastening area for fastening in a blood vessel, which axially adjoins the valve frame (2). A stabilizing ring (14) is arranged in the fastening area.

Valved stent for mitral and tricuspid heart valve replacement

An implantable valved stent for a patient's heart is formed by a stent supporting a cloth structure. The valved stent includes an upper mounting portion and a lower valved portion.
Peijia Medical Co., Ltd.

Heart valve prosthesis

A heart valve prosthesis includes a downstream first axial end (6) and an upstream second axial end (8) and a stitching ring (10) extending in an arcuate manner for stitching in a blood vessel. The arcuate course of the stitching ring (10) is formed by three arcs (12) and three transition regions (14).

Device and improving heart valve function

The invention is a method for reducing regurgitation through a mitral valve. The device and method is directed to an anchor portion for engagement with the heart wall and an expandable valve portion configured for deployment between the mitral valve leaflets.
Edwards Lifesciences Ag

System and mapping the functional nerves innervating the wall of arteries, 3-d mapping and catheters for same

Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve.
Symap Medical (suzhou), Limited

C-arm field generating removing material from blood vessel walls

Systems and methods for removing plaque from blood vessels by applying constant or time varying magnetic or electrical fields. In one embodiment a system includes winding configurations positioned about a central axis along which a body region may be placed.
Advanced Magnet Lab, Inc.

Methods for delivery of bodily fluids onto a fibrous substrate

The disclosed apparatus, systems and methods relate to devices, systems and methods for the collection of bodily fluids. The collector can make use of microfluidic networks connected to collection sites on the skin of a subject to gather and shuttle blood into a removable cartridge.

Calculation of perfusion parameters in medical imaging

A method of determining a residue function in brain tissue, from medical images acquired after introducing contrast agent into the blood, correcting for contrast agent leakage into the tissue, comprising: a) providing time signals indicating contrast agent concentration for leaking voxels, a time signal indicating average contrast agent concentration for non-leaking voxels, and an artery input function, all derived from the images; b) fitting the leaking voxel signals to a model time signal with a free parameter for leakage rate, the model assuming that the concentration of contrast agent perfusing through a leaking voxel has a same shape as a function of time as the average contrast agent concentration for non-leaking voxels; c) using the best fit leakage rate parameter to make a correction for leakage to the leaking voxel signals; and d) deconvolving the corrected signals from the artery input function, to find the residue function.. .
Algotec Systems Ltd.

Method and system for monitoring blood pressure

A system for monitoring blood pressure includes a blood pressure cuff, a blood pressure measurement device removably connected to the blood pressure cuff, and a cuff verification module. The cuff verification module is executable on a processor to receive medical record information from a patient, determine an expected cuff size for the patient based on the medical record information, receive a detected cuff size for the blood pressure cuff, and verify that the detected cuff size is consistent with the expected cuff size..
General Electric Company

Blood pressure calculation method based on pulse return wave transmission time, and blood pressure monitor

A method for calculating blood pressure based on pulse return wave transmission time, and a blood pressure monitor have been provided. The method includes the following steps: s1: collecting and storing pulse waveform data at a fingertip; s2: processing said pulse waveform data to obtain a heart rate and parameters of a plurality of pulse periods, detecting time axis coordinates of a primary wave starting point spl1 of a pulse wave and a growth point spl2 of a return wave in each of said pulse periods, and calculating a corresponding pulse return wave transmission time rwtt: rwtt=spl2−spl1; s3: calculating the pulse return wave transmission time rwtt in each of said pulse periods to form a rwtt array; and s4: calculating systolic and diastolic pressures based on said rwtt array and the heart rate..
Hangzhou Nanochap Electronics Co., Ltd.

Blood pressure measurement data processing method and apparatus

A blood pressure measurement data processing method includes obtaining first calibration data of a user and pre-stored second calibration data of the user; determining, according to the first calibration data and the second calibration data, an optimal function used to represent a function relationship between a pulse wave transmission time and a blood pressure value of the user; obtaining a current pulse wave transmission time of the user; and calculating a current blood pressure value of the user according to the current pulse wave transmission time and the optimal function.. .
Huawei Technologies Co., Ltd.

Multi-model blood pressure estimation

One aspect of the subject matter described in this disclosure can be implemented in a device capable of use in estimating blood pressure. The device includes one or more arterial sensors configured to obtain arterial measurements at two or more elevations.
Qualcomm Incorporated

Wearable blood pressure monitoring system

An apparatus includes one or more memories storing computer readable code and processor(s). The processor(s), in response to loading and executing the computer readable code, cause the apparatus to perform operations including receiving electrocardiogram data from an electrocardiogram sensor.
International Business Machines Corporation

Wearable blood pressure monitoring system

An apparatus includes one or more memories storing computer readable code and processor(s). The processor(s), in response to loading and executing the computer readable code, cause the apparatus to perform operations including receiving electrocardiogram data from an electrocardiogram sensor.
International Business Machines Corporation

Systems and methods for monitoring and updating blood flow calculations with user-specific anatomic and physiologic sensor data

Systems and methods are disclosed for informing and monitoring blood flow calculations with user-specific activity data, including sensor data. One method includes receiving or accessing a user-specific anatomical model and a first set of physiological characteristics of a user; calculating a first value of a blood flow metric of the user based on the user-specific anatomical model and the first set of physiological characteristics; receiving or calculating a second set of physiological characteristics of the user by accessing or receiving sensor data of the user's blood flow and/or sensor data of the user's physiological characteristics; and calculating second value of the blood flow metric of the user based on the user-specific anatomical model and the second set of physiological characteristics of the user..
Heartflow, Inc.

System and methods for estimation of blood flow characteristics using reduced order model and machine learning

Systems and methods are disclosed for determining blood flow characteristics of a patient. One method includes: receiving, in an electronic storage medium, patient-specific image data of at least a portion of vasculature of the patient having geometric features at one or more points; generating a patient-specific reduced order model from the received image data, the patient-specific reduced order model comprising estimates of impedance values and a simplification of the geometric features at the one or more points of the vasculature of the patient; creating a feature vector comprising the estimates of impedance values and geometric features for each of the one or more points of the patient-specific reduced order model; and determining blood flow characteristics at the one or more points of the patient-specific reduced order model using a machine learning algorithm trained to predict blood flow characteristics based on the created feature vectors at the one or more points..
Heartflow, Inc.

Renal therapy machine and system with blood pressure monitor

A renal therapy machine with a blood pressure monitor is disclosed. In an example, a renal therapy machine includes a dialysis fluid pump a control processor for controlling a treatment performed by the dialysis fluid pump, and a user interface in operable communication with the control processor.
Baxter Healthcare Sa

Method and establishing a blood pressure model and determining a blood pressure

The embodiments of the present disclosure disclose a method and apparatus for establishing a blood pressure model. The method comprises: acquiring pulse wave data, electrocardiographic data, blood pressure data and body mass indexes of a plurality of subjects to be examined; determining pulse wave transit time and pulse wave intensity ratios based on the pulse wave data and the electrocardiographic data; establishing a blood pressure model based on the blood pressure data, the pulse wave transit time, the pulse wave intensity ratios, and/or the body mass index..
Boe Technology Group Co., Ltd.

Compositions and methods to assess the capacity of hdl to support reverse cholesterol transport

The invention provides compositions and methods for assessing the capacity of high density lipoprotein (hdl) to support reverse cholesterol transport in blood by measuring exchange if hdl-specific spin-labeled lipoprotein probes and electron paramagnetic spectroscopy. The invention also provides methods to identify individuals at risk for cardiovascular disease, to monitor the treatment of cardiovascular disease and in the development of therapies to treat cardiovascular disease.
Children's Hospital & Research Center At Oakland

Method of detecting platelet activating antibodies that cause heparin-induced thrombocytopenia/thrombosis

The present invention provides a method of detecting platelet activation in a patient, the method comprising the steps of a) obtaining a blood sample from a patient suspected of having heparin-induced thrombocytopenia (hit); b) incubating an effective amount of platelet factor 4 (pf4) with a sample of platelets to yield a sample of pf4-treated platelets; c) contacting the patient blood sample with the pf4-treated platelets; and d) measuring the extent of platelet activation, wherein an increase in platelet activation compared with results obtained using a normal blood sample is indicative of the patient having hit.. .
Blood Center Research Foundation

Method for measuring glycemic index of human-consumed food

The glycemic index is determined based on the results of blood glucose concentration measurements by evaluating time Δt from the beginning of food-related increase of blood glucose concentration until the peak of glucose concentration is reached, after which maximum increase Δgmax of said glucose concentration is determined over the given period of time. Thereat, the glycemic index of food is defined as a ratio of maximum increase of blood glucose concentration Δgmax versus maximum increase of said glucose concentration in case of pure glucose intake in the amount equal to carbohydrate content of the consumed food, which is proportional to the product of Δgmax by Δt.
Healbe Corporation

Method for stabilizing glycerophospholipids and reagents using same

Disclosed is an accurate and stable immunoassay reagent using a glycerophospholipid and a method for stabilizing the reagent. The reagent for assaying an analyte in blood by immune reaction with an antigen when the analyte is an antibody or with an antibody when the analyte is an antigen, wherein a glycerophospholipid and a polyvinylpyrrolidone are incorporated into the immune reaction system..
Sekisui Medical Co., Ltd.

Devices and methods for filtering blood plasma

The present invention provides systems, devices, kits, and methods for separating blood plasma from whole blood. In particular, the present invention provides systems, devices, and methods for separating a fixed volume of blood plasma from whole blood with minimal energy input..
Northwestern University

Electrical measurement method, electrical measurement device, and blood condition analysis system

Provided is a technique that allows high-accuracy electrical measurement without the influence of blood sedimentation in a case where various measurements or evaluations are performed using blood samples containing a blood cell component and a plasma component. Provided is an electrical measurement method for electrically measuring a blood sample including at least a blood cell component and a plasma component, the electrical measurement method including the step of adding a blood sedimentation inhibitor to the blood sample.
Sony Corporation

Recombinant protein-based the delivery of silencer rna to target the brain

The present invention relates to the design and development of recombinant protein for the delivery of silencer rna complex to mediate rna interference since it represents a novel therapeutic approach to modulate several neurodegenerative disease-related genes across the blood-brain barrier (bbb). To overcome challenges due to this barrier for biologics and other biological complex, the present invention describes a method wherein peptide having sequence gggghlnilstlwkyrc represented by seq id no.
Council Of Scientific & Industrial Research

Method of measuring adaptive immunity

A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it.
Fred Hutchinson Cancer Research Center

Vascularized skin models

A synthetic skin tissue is served by at least one synthetic blood vessel and includes a physiologically representative population of cells including fibroblasts and keratinocytes, wherein some keratinocytes are in a differentiated state.. .
The Government Of The United States Of America, As Represented By The Secretary Of The Navy

Generating virus or other antigen-specific t cells from a naÏve t cell population

Safe, rapid and efficient methods for producing virus-specific or other antigen-specific t-cells from cord blood and other samples containing naive immune cells.. .
Children's National Medical Center

Ceramic inkjet ink for red decoration

Disclosed are compositions, such as inkjet inks, for jetting onto a ceramic substrate, and associated methods and systems. The compositions comprise a pigment compound that is configured to be jetted on a ceramic substrate during a ceramic inkjet process to impart a color effect to the ceramic substrate, and a reduction agent which, when exposed to a firing temperature, reacts with the pigment compound to cause a reduction reaction.
Electronics For Imaging, Inc.

Tfpi inhibitors and methods of use

The invention provides peptides that bind tissue factor pathway inhibitor (tfpi), including tfpi-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a tfpi, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, and/or treat a blood coagulation disorder in a subject..
Baxalta Incorporated

Crystalline form alpha of ipi-145 and preparation method thereof

The present disclosure relates to crystalline form α of a compound of formula (i) used for preparing a blood-cancer drug and preparation method thereof. The crystalline form α in the present disclosure has better stability, and its solubility and hygroscopicity meet the requirements of medical use.
Crystal Pharmatech Co., Ltd.

Bioactive glass scaffolds, and making

A glass, glass-ceramic, or ceramic bead is described, with an internal porous scaffold microstructure that is surrounded by an amorphous shield. The shield serves to protect the internal porous microstructure of the shield while increasing the overall strength of the porous microstructure and improve the flowability of the beads either by themselves or in devices such as biologically degradable putty that would be used in bone or soft tissue augmentation or regeneration.
Mo Sci, Corp.

Wireless midfield systems and methods

Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters.
The Board Of Trustees Of The Leland Stanford Junior University

Blood control for a catheter insertion device

A fluid control component configured for controlling fluid flow through the hub of a catheter assembly during and after placement into the patient is disclosed. In one embodiment, the fluid control component comprises a body disposed within a cavity of the hub, the body being movable between a first position and a second position, wherein the body does not pierce a valve disposed in the hub when in the first position and wherein the body pierces the valve when in the second position.
C. R. Bard, Inc.

System and optimizing contrast imaging of a patient

Systems and methods are provided for imaging a patient. Target imaging parameters for imaging a region of interest of a patient are determined based on desired attributes of images to be generated for the region of interest.
Siemens Healthcare Gmbh

Method for collecting a desired blood component and performing a photopheresis treatment

An improved method for separating whole blood into components and collecting a desired blood component. The method allows a desired blood component to be subjected to centrifugal forces within a separator for prolonged periods of time, yielding a cleaner cut and higher yield of the desired blood component.
Therakos, Inc.

Blood purification apparatus

A blood purification apparatus includes a blood circuit through which blood of a patient extracorporeally circulate, and a dialyzer that purifies the blood flowing in the blood circuit. The apparatus includes a pressure-change-producing device capable of applying a positive pressure or a negative pressure to distal portions of the blood circuit while an arterial puncture needle (a) and a venous puncture needle (b) are yet to be connected to the blood circuit, a pressure-change-detecting device capable of detecting pressure changes in the distal portions of the blood circuit that occur when the distal portions of the blood circuit that are under the positive pressure or the negative pressure applied by the pressure-change-producing device are connected to the arterial puncture needle (a) and the venous puncture needle (b) that are stuck in the patient, and an evaluation device capable of evaluating a state of sticking of the arterial puncture needle (a) and the venous puncture needle (b) on the basis of the pressure changes detected by the pressure-change-detecting device..
Nikkiso Company Limited

Method for determining at least one parameter of an extracorporeal blood circuit as well as apparatuses

A method for determining at least one parameter of an extracorporeal blood circuit includes the steps of filling an extracorporeal blood circuit, e.g., encompassing a medical functional device, a treatment device and/or a blood tube set, by introducing a fluid, and detecting a volume of the introduced fluid which is required for filling the extracorporeal blood circuit by a detection device. A control device, a treatment apparatus, a computer readable storage medium, a computer program product as well as a computer program are also described..
Fresenius Medical Care Deutschland Gmbh

External functional means, blood treatment receiving an external functional means in accordance with the invention, and method

An external functional means comprises at least one housing body, at least one chamber integrated into the housing body for receiving medical fluids, at least one passage integrated into the housing body for receiving and/or conducting a medical fluid, and at least one valve means completely or partly integrated into the housing body for controlling or regulating a fluid flowing through the external functional means. The invention further specifies a blood treatment apparatus and methods which may be carried out by means of the external functional means of the invention and by means of the blood treatment apparatus, respectively..
Fresenius Medical Care Deutschland Gmbh

Sealant formulations and uses thereof

The invention relates to a storage-stable aqueous sealant formulation comprising a blood derived fibrinogen concentrate, a divalent cation and factor xia.. .
Omrix Biopharmaceuticals Ltd.

Endonuclease targeting blood coagulation factor viii gene and composition for treating hemophilia comprising same

The present invention provides a method for inducing an inversion of normal blood coagulation factor viii (f8) gene, a method for correcting an inversion of blood coagulation factor viii gene in which the inversion has occurred, and a hemophilia a patient-derived induced pluripotent stem cell in which the inversion is corrected, constructed using the same. The method of the present invention effectively reproduces the inversion of intron 1 and intron 22 of the f8 gene, which is responsible for the majority of severe hemophilia a, and thereby may be effectively used for studying the development mechanism of hemophilia a and as a research tool for screening therapeutic agents.
Institute For Basic Science

Herbal supplement ''optimal cholesterol''

“optimal cholesterol” utilizes edible nature plant extracted by a variety of technology, it is one of the nature plant medicines which can treat atherosclerotic coronary heart disease, cerebral vascular disease and systemic vascular disease in the world. Its function is to soften the arterial blood vessels, and to treat arteriosclerosis, protect and repair the vascular endothelial cells; soft plaque, fibrous plaque and calcified plaque are removed during the process of preventing plaque rupture, bleeding, erosion and ulcer; regulate micro-circulation, enhance the ability of coronary artery blood supply, adjust heart rate, furthermore, there's none toxic side effects after long-term use..

Medical product for reducing and/or eliminating symptoms of nicotine withdrawal

In essence, the present invention relates to a medical product including between about 94% and about 98% of a saline solution, preferably a normal saline solution containing about 0.9% sodium chloride dissolved in water, about ⅛th of 1 milligram of relatively pure nicotine and about 3 milligrams of relatively pure nicotine. The medical product also includes about 1% and 3% of one or more flavors selected from the group consisting of citrus, tobacco, apple, cherry, maple, menthol, hazelnut, peach, lemon, vanilla and chocolate and 1% citric acid for taste.

Use of ferric citrate in the treatment of iron-deficiency anemia

Described herein are methods for treating patients with iron-deficiency anemia (ida), comprising administering ferric citrate to such patients. In certain aspects, the patients treated for iron-deficiency anemia have a gastrointestinal disorder, such as inflammatory bowel disease, inflammatory bowel syndrome, crohn's disease, microscopic colitis (such as collagenous or lymphocytic colitis), or chemically-induced colitis (e.g., nsaid (nonsteroidal anti-inflammatory drug)-induced colitis).
Keryx Biopharmaceuticals, Inc.

Medical stent

In an embodiment, a stent is provided for use in blood vessels with blockage near or in a bifurcation. The stent includes a side aperture.
Rbkpark Llc

Prosthetic heart valve with paravalvular leak mitigation features

A prosthetic heart valve includes a collapsible and expandable stent with a valve assembly disposed therein. A first cuff is positioned on the lumenal or ablumenal surface of the stent.
St. Jude Medical, Cardiology Division, Inc.

Aneurysm treatment method

A method for treating an aneurysm with at least one branch blood vessel branched from a diseased aorta comprises implanting an aortic stent graft and an auxiliary stent into a diseased blood vessel to isolate the aneurysm, wherein the auxiliary stent comprises a bifurcated stent graft, one end of the aortic stent graft is attached to the wall of a healthy blood vessel upstream of the aneurysm, and the auxiliary stent comprises a body portion and a branch portion communicated with the body portion, one end of the body portion is communicated with a healthy blood vessel downstream of the aneurysm, the other end of the body portion is communicated with the aortic stent graft, and the branch portion is suspended within the diseased blood vessel. A straight stent graft is advanced towards the branch portion from the location downstream of the bifurcated stent graft and deployed to communicate the branch portion and the branch blood vessel..
Lifetech Scientific (shenzhen) Co., Ltd.

Tip for an intraoral scanner

The present invention relates to a tip for an intraoral scanner, comprising: a housing body having an imaging unit through which images are transferred to an imaging module of the intraoral scanner, at least one aperture adapted to provide gas streams, wherein said at least one aperture is configured such that during a scanning session a scanned region is first being cleaned (e.g., from blood or oral particles) by gas streams prior to the actual scanning of said region by said imaging unit, while after the cleaning and during the actual scanning of said region, said at least one aperture causes gas streams to diffuse around the entire periphery of said cleaned and scanned region.. .

Method and system for image processing to determine blood flow

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data.
Heartflow, Inc.

Ultrasound catheter

A system and a method for disrupting an occlusion within a blood vessel is provided the system includes an elongated catheter body having a proximal portion, a distal portion, and a first lumen. The system further includes an ultrasound transmitter extending longitudinally through the first lumen of the catheter body and having a proximal end and a distal end.
Indiana University Research & Technology Corporation

Arterial wall compression stent

A compression stent for applying a localized high stress against a blood vessel wall to cause vessel wall compression and blockage of sympathetic and nerve signal transmission within the wall of a blood vessel. The compression stent can also sever nerves located in the vessel wall.

Biodegradable blood vessel occlusion and narrowing

A biodegradable blood vessel narrowing device, comprising: a biodegradable element; an anchoring element; wherein said anchoring element is anchored to a blood vessel wall and at least one external dimension of said biodegradable element is reduced upon biodegradation of said biodegradable element thereby pulling said blood vessel walls toward one another.. .
V.v.t. Med Ltd.

Ultrasonic diagnostic device

The present invention, relates to an ultrasonic diagnostic device that simultaneously displays an imt and the elastic indices of a blood vessel to determine, the risk for developing arteriosclerosis. The ultrasonic diagnostic device includes: an ultrasonic probe that transmits ultrasound to a body and receives ultrasonic echo to output a reception signal; image data generation mechanism that generates, based on the reception signal, image data representing an ultrasonic image on a blood vessel of the body; imt measurement mechanism that measures, based on the image data, an imt of the blood vessel; elastic index measurement mechanism that determines, based on the image data, a value representing an elastic index of the blood vessel; and a display that displays a two-dimensional coordinate system in which the imt is represented on a first coordinate axis and the value representing the elastic index of the blood vessel is represented on a second coordinate axis..
Fujifilm Corporation

Blood pressure measuring device and blood pressure measuring method using the same

There is provided a blood pressure measuring device comprising: a first heart rate measuring module configured to measure a first heart rate at a first location of an examinee's body; a second heart rate measuring module configured to measure a second heart rate at a second location of the examinee's body, wherein the first location is different from the second location, wherein a first spacing between the first location and a heart of the examinee is different from a second spacing between the second location and the heart of the examinee; and a blood pressure estimation module configured to estimate a blood pressure of the examinee based on the first and second heart rates measured by the first and second heart rate measuring modules.. .
Gwangju Institute Of Science And Technology

Systems and methods for enhancing uptake of therapeutic agent from bloodstream into disease sit

A method for enhancing uptake of a therapeutic agent from the bloodstream of a patient into a disease site of the patient includes applying negative pressure to the disease site to form a pressure differential favorable for transport of the therapeutic agent from the bloodstream into the disease site. A system for enhancing uptake of therapeutic agent from the bloodstream of a patient into a disease site of the patient includes (a) a partial enclosure with edge configured to interface with an exposed surface, of the patient and overlying the disease site, to seal the partial enclosure to the exposed surface, and (b) a pump for evacuating air from the partial enclosure to produce a partial vacuum in the partial enclosure, to apply a negative pressure to the disease site so as to enhance uptake of the therapeutic agent into the disease site..
The Trustees Of Dartmouth College

Non-invasive nanosensor system to determine analyte concentration in blood and/or bodily fluids.

The device is an ultra-low power, non-invasive in-vivo blood analyte sensor system incorporating multiple sensors including a carbon base and/or carbon base material coated with metallic nanoparticles and/or metallic nanoparticle nanoprobes, as a modified clark electrode sensor system, that detects hydrogen peroxide concentrations, ph, and/or glucose concentrations (and other analytes) in bodily secretions (e.g. Tears, saliva, sweat).

Method and determining cardiac performance in a patient with a conductance catheter

An apparatus for determining cardiac performance in the patient includes a plurality of electrodes adapted to be placed in the patient and in communication with a heart chamber of the patient for measuring conductance and blood volume in the heart chamber of the patient; and a processor for determining instantaneous volume of the ventricle based on measurement of complex admittance at a plurality of frequencies to identify mechanical strength of the chamber, the processor in communication with the electrodes. A method for determining cardiac performance in a patient..
Board Of Regents, The University Of Texas System

Microangiography method and system based on full-space modulation spectrum splitting and angle compounding

A microangiography method and system based on full-space modulation spectrum splitting and angle compounding is disclosed. Label-free three-dimensional optical coherence tomography angiography is realized by combining the three-dimensional space resolution capability of an optical coherence tomography and the motion recognition capability of a dynamic scattering technology.
Zhejiang University

Blood pressure measuring device

Disclosed herein is a blood pressure measuring device including: a pressure measuring tool 110; a fastening member 120 configured to fasten the pressure measuring tool 110 in rest position onto a skin region covering an anastomotic region of a shunt blood vessel 201; and a control circuit 130 configured to receive an input signal from the pressure measuring tool 110 and to process the input signal to calculate a pressure inside the anastomotic region of the shunt blood vessel 201.. .
Nipro Corporation

Method and measuring blood pressure

According to an aspect, there is provided an apparatus for measuring the blood pressure, bp, of a user, the apparatus comprising a volume-clamp bp monitoring device that comprises a first pressure device for applying pressure to a first part of the body of the user, a first photoplethysmogram, ppg, sensor for obtaining a first ppg signal from the first part of the body of the user, and a control unit that is configured to analyse the first ppg signal and to control the pressure of the first pressure device; wherein the control unit is configured to adjust the pressure of the first pressure device to maintain the first ppg signal at a constant level and to determine the bp of the user from the pressure of the first pressure device; and a second sensor, separate from the first ppg sensor, for measuring a physiological characteristic of the user in a second part of the body of the user, wherein the second part of the body is separate from the first part of the body; wherein the apparatus is configured to analyse the measured physiological characteristic to determine a measure of the blood perfusion in the second part of the body of the user, and to determine whether to perform a recalibration of the volume-clamp bp monitoring device on the basis of changes in the blood perfusion.. .
Koninklijke Philips N.v.

Tube for blood pressure cuff and blood pressure cuff

A tube for a blood pressure cuff includes a hollow and long shape, and plural projection portions projecting toward a center of a regular polygon in correspondence with vertices of the regular polygon which inscribes in an outer circumference and has 5 or more angles, in a shape of an inner circumference in a cross section perpendicular to a longitudinal direction of the cuff tube.. .
Nihon Kohden Corporation

System and monitoring absolute blood flow

A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical data from the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and.
The General Hospital Corporation

Device for acquiring physiological variables measured in a body

An eavesdropping arrangement for acquiring a measured physiological variable of an individual includes a receiver and a communication interface in a housing separate from the receiver. The communication interface is positioned along a communication link between a first sensor, which is configured to measure aortic blood pressure and to provide a signal representing measured aortic blood pressure, and a central monitoring device configured to monitor the measured aortic blood pressure.
St. Jude Medical Coordination Center Bvba

Mouthpiece measurement of biometric data of a diver and underwater communication

Embodiments of the invention provide a system, apparatus and methods for measurement of biometric data of a diver. In many embodiments, the system includes a mouthpiece having a sensor device comprising a light emitter and detector configured to emit and detect light at a wavelength having an absorbance correlated with a level of a blood gas saturation e.g., oxygen, nitrogen, co2.
Incube Labs, Llc

Ophthalmic imaging apparatus and ophthalmic image processing apparatus

An ophthalmic imaging apparatus of an embodiment includes a data acquisition unit, a blood vessel enhanced image forming unit, and a blood vessel gradient distribution determination unit. The data acquisition unit is configured to acquire a three dimensional data set of a fundus of a subject's eye using optical coherence tomography (oct).
Topcon Corporation

Blood feeding system using nonwoven fabric materials

Systems and methods for a blood feeding system using nonwoven fabric materials are disclosed. In one embodiment, a feeding pouch includes: a first surface comprising an impermeable material; a second surface comprising a nonwoven fabric material, the first surface bonded to the second surface to form a pouch; and blood deposited within the pouch..
Verily Life Sciences Llc

Osaka University

. .

Systems and methods for risk assessment and treatment planning of arterio-venous malformation

A computer implemented method for assessing an arterio-venous malformation (avm) may include, for example, receiving a patient-specific model of a portion of an anatomy of a patient; using a computer processor to analyze the patient-specific model for identifying one or more blood vessels associated with the avm, in the patient-specific model; and estimating a risk of an undesirable outcome caused by the avm, by performing computer simulations of blood flow through the one or more blood vessels associated with the avm in the patient-specific model.. .
Heartflow, Inc.

Methods and systems for assessing image quality in modeling of patient anatomic or blood flow characteristics

Systems and methods are disclosed for assessing the quality of medical images of at least a portion of a patient's anatomy, using a computer system. One method includes receiving one or more images of at least a portion of the patient's anatomy; determining, using a processor of the computer system, one or more image properties of the received images; performing, using a processor of the computer system, anatomic localization or modeling of at least a portion of the patient's anatomy based on the received images; obtaining an identification of one or more image characteristics associated with an anatomic feature of the patient's anatomy based on the anatomic localization or modeling; and calculating, using a processor of the computer system, an image quality score based on the one or more image properties and the one or more image characteristics..
Heartflow, Inc.

Method of determining target treatment locations

A method and system for automatic location of a target treatment structure, such as a pulmonary vein ostium, from an anatomical image. The method includes calculating a most likely path of blood flow through a pulmonary vein based on a cross-sectional area minimization technique and calculating pulmonary vein geometry as a function of length.
Medtronic, Inc.

Multi-step vessel segmentation and analysis

Multi-step vessel segmentation and analysis is provided. In various embodiments, a branch detection algorithm is applied to a medical image to determine a plurality of branches of a blood vessel appearing in the medical image.
International Business Machines Corporation

System and reducing partial voluming artifacts in quantitative myocardial tissue characterization

A system and method for obtaining magnetic resonance images are provided. The system is programmed to control the rf system to apply a saturation pulse at a reference frequency that saturates a selected labile spin species of the subject.
Regents Of The University Of Minnesota

System for measuring total hemoglobin in blood and doing the same

This invention relates to the measurement of hemoglobin in the blood. Previously, chemical interference from medications, other blood components, and incomplete reagent rehydration can impact the accuracy and prolong the reaction time required to determine total hemoglobin in blood.

Blood brain barrier models and methods to generate and use the same

The present disclosure generally relates to a process to prepare a cell culture system that mimics the structure of blood brain barrier (bbb) and are useful to study the functions thereof. In particular, the present invention relates to a direct-contact coculture and triculture systems prepared by plating bmecs on a pre-formed lawn of coculture of astrocytes and pericytes on the apical surface of a culture-chamber to achieve a truly direct contact triculture model for bbb.
Purdue Research Foundation

Diagnostics systems and methods

A point-of-care diagnostic system that includes a cartridge and a reader. The cartridge can contain a patient sample, such as a blood sample.
Hemex Health, Inc.

Pressure sensor, acoustic microphone, blood pressure sensor, and touch panel

According to one embodiment, a pressure sensor includes a film part, and a sensing unit. A circumscribing rectangle circumscribing a configuration of a film surface of the film part has a first side, a second side, a third side connected to one end of the first side and one end of the second side, a fourth side connected to one other end of the first side and one other end of the second side, and a centroid of the circumscribing rectangle.
Kabushiki Kaisha Toshiba

Use of trpc6 mrna levels in peripheral blood cells for early detection/diagnosis of senile dementia

The invention relates to the use of trpc6 mrna levels in peripheral blood cells for the early detection/diagnosis of senile dementia. Specifically, the present invention provides a classic transient receptor potential channel 6 (trpc6) gene or protein thereof and the use of same in preparing a reagent or test kit for detecting or diagnosing alzheimer's disease.
Aging Wise Biotechnology, Inc.

Widespread gene delivery to motor neurons using peripheral injection of aav vectors

The present invention relates to compositions and methods, in particular to methods based on systemic injection of raav, for delivering genes to cells of the central nervous system in mammals, such as brain neurons or glial cells, and in particular to motor neurons or glial cells of the spinal cord the invention also relates to methods of treating motor neuron disorders in mammals by expression of therapeutic genes. The invention stems from the unexpected discovery that peripheral injection of aav vectors leads to a bypass of the blood brain barrier and a massive infection of motor neurons.
Centre National De La Recherche Scientifique

Method for preparing dendritic cells via non-adhesive culture using ifn

This invention provides a method for preparing dendritic cells from monocytes with the use of interferon α via non-adhesive culture. The method for preparing cytotoxic dendritic cells from monocytes comprises subjecting monocytes which were isolated from the peripheral blood to non-adhesive culture in the presence of gm-csf and pegylated interferon α, and further conducting non-adhesive culture with the addition of prostaglandin e2 and ok432..
Shinshu University

Universal blood product and methods of preparing and using same

A method of preparing a universal blood product comprising obtaining a blood product; contacting the blood product with (i) hydroxyapatite; (ii) a carbonaceous material comprising at least a mixture of a first carbon particle having macroporous size α and a second carbon particle having macroporous size β; and (iii) at least one support matrix chemically associated with an antigenic determinant.to form a cleansed product; and recovering the cleansed product. A method of preparing a universal blood product comprising obtaining a blood product; contacting the blood product with (i) hydroxyapatite; (ii) a carbonaceous material comprising at least a mixture of a first carbon particle having macroporous size α and a second carbon particle having macroporous size β; and (iii) at least one support matrix chemically associated with an antigenic determinant.to form a cleansed product; wherein at least one of the hydroxyapatite, carbonaceous material and support matrix is functionalized..
Immutrix Therapeutics, Inc.

Methods and devices for treating erectile dysfunction

Methods and devices for treating erectile dysfunction are disclosed. Methods are aimed at reducing blood outflow from penile tissue by delivering energy to specific penile tissue that controls blood outflow from the penile tissue and causing remodeling of the specific penile tissue.
Ohh-med Medical Ltd.

Method and intra-aortic substance delivery to a branch vessel

A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bi-laterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having an injection port that couples to a source of fluid agent externally of the patient.
Angiodynamics, Inc.

Medical needle, and closing protector of medical needle

A medical needle is provided with a needle body and a protector including a housing space which houses the needle body after venipuncture by the needle body by relative movement of the needle body in an axial direction. The protector has an annular recess in the entire circumference in the circumferential direction of an inner face in the housing space so as to accumulate blood that spatters from the needle body..
Terumo Kabushiki Kaisha

Optical blood detection system

The present invention relates to an optical blood detector system that rapidly detects the presence of blood due to a blood leak in a system. The blood detector system contains a reusable blood sensor that is able to accurately detect the presence of blood in, for example, an extracorporeal blood treatment system by optically sensing light from a sensing region and determining if the light came from a leaked blood.
Fresenius Medical Care Holdings, Inc.

Artificial ventricles

A artificial ventricle comprises an inlet for receiving blood, an outlet for discharging blood, and a chamber disposed between the inlet and the outlet. There is also a mechanism for actuating the artificial ventricle between an expanded configuration and a contracted configuration.
Corvivo, Inc.

Rotary blood pump with opposing spindle magnets, bore and drive windings

Various “contactless” bearing mechanisms including hydrodynamic and magnetic bearings are provided for a rotary pump as alternatives to mechanical contact bearings. In one embodiment, a pump apparatus includes a pump housing defining a pumping chamber.
Tc1 Llc

Axial flow blood pump

The invention generally relates to improved medical blood pump devices, systems, and methods. For example, blood pumps may be provided that include a housing defining a blood flow path between an inlet and an outlet.
Tc1, Llc

Integrated sensors for intraventricular vad

A ventricular assist device includes a pump including a housing having an inlet, an outlet and a moveable element disposed in the housing for urging blood from the inlet to the outlet. An outflow cannula having a proximal end attached to the pump housing, a distal end remote from the pump housing, an interior bore in communication with the outlet of the pump housing, and at least one outlet aperture communicating with the interior bore remote from the pump housing is included.
Heartware, Inc.

System for extended storage of red blood cells and methods of use

A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described..
New Health Sciences, Inc.

In situ forming hemostatic foam implants

Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams.
Arsenal Medical, Inc.

Use of resected liver serum for whole liver-engineering

The disclosure provides a method of using blood or fractions thereof, e.g., serum, obtained from a mammal subjected to liver surgery, for example, obtained following a partial hepatectomy, to increase the engraftment, proliferation and/or functionality of cells on a biocompatible scaffold.. .
Mayo Foundation For Medical Education And Research

Contrast imaging agent with dissolved gas-evolving fluid

A diagnostic contrast composition includes a carrier fluid and a non-decaying gas-evolving fluid incorporated in the carrier fluid. The gas-evolving fluid has a vapor pressure sufficient to evolve the gas from a circulatory system within a lung of a patient.
Bayer Healthcare Llc

Implantable meshes for controlling the movement of fluids

Meshes for use to control the movement of bodily fluids, such as blood, are described herein. The mesh can be partially or completely biodegradable or non-biodegradable.
Arch Biosurgery, Inc.

Composite with the function of regulating blood glucose

A composite with the function of regulating blood glucose is formed into a tablet by clustering and mixing bitter gourd extract, olive extract, cinnamon extract, zinc gluconate, and chromium yeast. Animal experiment results clearly show that diabetic patients have significant improvements by taking a blood glucose regulating tablet with the compound recipe of the composite..

Differentiated lymph drainage garment

In the field of medical devices for the treatment of diseases related to blood circulation, a garment is provided which is capable of improving the lymph drainage of adipose tissues of the legs. The differentiated lymph drainage garment is characterized by at least two areas, a front one and a back one, contiguous to each other, each made with a fabric divided into bands having a decreasing elasticity from the bottom upwards.

System and methods for endovascular aneurysm treatment

Embodiments provide methods and systems for treating aneurysms using filling structures filled with a curable medium. An embodiment of a method comprises positioning at least one double-walled filling structure across the aneurysm and filling the structure(s) with a filling medium so that an outer wall conforms to the inside of the aneurysm and an inner wall forms a generally tubular lumen to provide for blood flow.
Nellix, Inc.

Automated retrievable hemorrhage control system

Some implementations of an endovascular device include a stent graft with an expandable tubular metallic frame and a covering material disposed on at least a portion of the metallic frame. The stent graft defines a lumen therethrough.
Board Of Regents Of The University Of Nebraska

Device for regulating blood flow

An implantable device for regulating blood flow through a blood vessel comprising an elongated support dimensioned and configured to be implanted in a blood vessel. The support includes a linking member linking axially spaced apart portions to one another.
Deep Vein Medical, Inc.

Vessel dissection and harvesting apparatus, systems and methods

Apparatus, systems, and methods for endoscopic dissection of blood vessels and control over cavity pressure within an endoscopic procedure are described herein. Apparatus, systems, and methods for harvesting of blood vessels are also described herein..
Mayo Foundation For Medical Education And Research

Modeling blood-brain barrier in vitro

Synthetic human blood vessels can be constructed using human brain derived endothelial cells and incorporated into a tissue model that contains astrocytes and other neurons and microglia. Multi-cell type microvessels incorporate cell types such as astrocytes and pericytes in order to construct a highly representative blood-brain barrier in vitro model with a functional lumen containing brain-derived microvascular endothelial cells and a polymer wall containing human astrocytes and/or pericytes..
The Government Of The United States Of America, As Represented By The Secretary Of The Navy

Simultaneous rotating separator, irrigator microcatheter for thrombectomy

The described invention provides several aspects designed to help mechanically break up a clot inside vessels and/or remove a clot via aspiration simultaneously. According to some embodiments, the devices are adapted to irrigate a blood vessel during thrombectomy; to macerate an obstruction during thrombectomy, to block blood flow in a blood vessel during aspiration of a thrombus; or to capture and remove distal emboli.

Atherectomy devices and methods

This document describes rotational atherectomy devices and systems for removing or reducing stenotic lesions in blood vessels by rotating an abrasive element within the vessel to partially or completely remove the stenotic lesion material.. .
Cardio Flow, Inc.

Rotating separator, irrigator microcatheter for thrombectomy

The described invention provides several aspects designed to help mechanically break up and/or lyse a clot inside vessels and/or remove a clot via aspiration. According to some embodiments, the devices are adapted to irrigate a blood vessel during thrombectomy; to macerate an obstruction during thrombectomy, to block blood flow in a blood vessel during aspiration of a thrombus; or to capture distal emboli..

System and treating heart tissue

Some embodiments of a system or method for treating heart tissue can include a control system and catheter device operated in a manner to intermittently occlude a heart vessel for controlled periods of time that provide redistribution of blood flow. In particular embodiments, the system and methods may be configured to monitor at least one input signal detected at a coronary sinus and thereby execute a process for determining a satisfactory time period for the occlusion of the coronary sinus.
Miracor Medical Systems Gmbh

Method and system for measuring pulmonary artery circulation information

Minimally invasive systems and methods are described for measuring pulmonary circulation information from the pulmonary arteries. A transbronchial doppler ultrasound catheter is advanced through the airways and in the vicinity of the pulmonary artery.
Pneumrx, Inc.

Imaging systems including multi-tap demodulation pixels for biometric measurements

Imaging systems include multi-tap demodulation pixels for biometric measurements such as heart rate or blood oxygen level. Using multi-tap demodulation pixels can, in some cases, help facilitate the generation of differential signals to remove background noise and achieve a higher dynamic range for the biometric measurements..
Heptagon Micro Optics Pte. Ltd.

Diagnostics systems and methods

A point-of-care diagnostic system that includes a cartridge and a reader. The cartridge can contain a patient sample, such as a blood sample.
Hemex Health, Inc.

Multispot monitoring for use in optical coherence tomography

Optical coherence tomography (herein “oct”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue.
Masimo Corporation

Device and spectrum analysis and device for blood glucose measurement

A device and method for spectrum analysis in which differences among skin spectra are quantitatively analyzed, and a blood glucose measurement device are provided. The device for spectrum analysis includes an obtainer configured to acquire a plurality of skin spectra; and a processor configured to generate a plot of difference degree of spectra which represents differences among the acquired plurality of skin spectra, and determine whether the plurality of skin spectra are appropriate for blood glucose measurement based on the plot of difference degree of spectra..
Samsung Electronics Co., Ltd.

Wearable cardiac electrophysiology measurement devices, software, systems and methods

Disclosed are wearable devices, such as rings and bracelets, for monitoring and diagnosing cardiovascular conditions of a wearer, along with related systems, algorithms and methods. The disclosed wearable devices can continuously monitor the wearer's cardiovascular status by measuring heart rate, motion, blood oxygenation, and/or other properties of the wearer.
Upmc

Applications of vasculature mapping using laser speckle imaging

Systems are provided for detecting the flow of blood or other fluids in biological tissue by illuminating the biological tissue with a coherent light source and detecting time-varying patterns of constructive and destructive interference in light received from portions of the biological tissue by an imager. The movement of blood cells and other light-scattering elements in the biological tissue causes transient, short-duration changes in light emitted from portions of the biological tissue proximate to the moving blood cells or other scatterers.
Verily Life Sciences Llc

System to diagnose and manage orthostatic intolerance

An apparatus includes a posture sensing circuit configured to detect a change in posture of a subject; a cardiac signal sensing circuit configured to generate a sensed cardiac signal, wherein the sensed cardiac signal includes heart rate information of the subject; a physiologic sensing circuit configured to generate a sensed physiologic signal, wherein the physiologic signal includes information related to blood pressure of the subject; a storage buffer; and a control circuit operatively coupled to the posture sensing circuit and the storage buffer. The control circuit is configured to initiate storage of the heart rate information and the information related to blood pressure in response to a detected change in posture of the subject..
Cardiac Pacemakers, Inc.

Photo-acoustic sensing apparatus and methods of operation thereof

A photo-acoustic sensing apparatus (100) for non-invasive measurement of blood parameters of a subject (102) comprises a photo-acoustic sensor (104) for sensing photo-acoustic signals (106) induced when a region of the subject is illuminated by a light source (108). A first sensor processing module (112) may derive blood oxygen saturation using sensed photo-acoustic signals (114).
Nanyang Technological University

Ophthalmic analysis apparatus and ophthalmic analysis method

An ophthalmic analysis apparatus for analyzing oct motion contrast (mc) image data of a subject's eye acquired using an oct apparatus for ophthalmology includes analysis process means for analyzing the oct mc image data, in which the analysis process means generates oct blood vessel change data including temporal change information in relation to a blood vessel region of the subject's eye based on first oct mc image data and second oct mc image data acquired at mutually different times.. .
Nidek Co., Ltd.

Fundación Pública Andaluza Progreso Y Salud

. .

Hydrogel structure, blood vessel, internal organ model, practice tool for medical procedure, and manufacturing the hydrogel structure

A hydrogel structure includes a hollow tubular structure having an inner diameter of 1.0 mm or less, wherein the hydrogel structure has a transmission of 80 percent or more in a visible light range.. .

Requisition system for supply/maintenance of safety items

A requisition system for safety items such as first aid kits, blood borne pathogen kits, automatic external defibrillators, fire extinguishers, smoke detectors and carbon monoxide detectors automatically generates a list of supplies for such items. The requisition system operates on a mobile electronic device.
Acme United Corporation

Network topology for insulin pump systems

In one implementation, an insulin delivery system using an on-body network includes an insulin delivery device that is adapted to administer dosages of insulin to a patient; a controller that is adapted to control operation of the insulin delivery device, to establish a first network connection in which the controller acts in a central role, and to establish a second network connection in which the controller acts in a peripheral role; one or more peripheral devices that are adapted to generate patient data related to blood glucose levels and to transmit the patient data wirelessly over the first network connection, the peripheral devices acting in a peripheral role over the first network connection; and a mobile application installed on a mobile computing device that is programmed to communicate with the controller over the second network connection, the mobile application communicating in a central role over the second network connection.. .
Bigfoot Biomedical, Inc.

Devices, systems, and methods for physiology monitoring

Software applications, devices, systems, and methods are provided for monitoring, recording, and tracking cardiac health related metrics using an associated computing device. The software applications may monitor, record, and track physiological data such as cardiac electrical activity, heart rate, and blood pressure.
Alivecor, Inc.

Controlled blood delivery to mixing chamber of a blood testing cartridge

Embodiments of a blood coagulation testing system can operate as an automated thromboelastometry system that is particularly useful, for example, at a point-of-care site. In some embodiments, the blood coagulation testing system includes a single-use cartridge component configured to measure and mix reagents with blood received from a blood sample reservoir.
C A Casyso Ag

Apparatus and early identification of tpa resistance for clot dissolution in patients

Recombinant tissue plasminogen activator (tpa) is a lytic medication in wide use to treat thrombotic disorders such as stroke, myocardial infarction (mi), and pulmonary embolism (pe). It is also used “off-label” for the treatment of deep venous thrombosis (dvt) and acute peripheral arterial thrombosis/embolism.

Method and kit for diagnosing depression after acute coronary syndrome using homocysteine

This invention relates to a method of diagnosing the depression, and more particularly to a method and kit for diagnosing depression after acute coronary syndrome, by measuring the concentration of a specific biomarker in the blood of a patient suffering from acute coronary syndrome to predict depression after acute coronary syndrome.. .
Industry Foundation Of Chonnam National University

Magnetic nanostructure for detecting and isolating circulating tumor cells comprising antibody- and magnetic nanoparticle-conjugated conductive polymer

Disclosed is a magnetic nanostructure for detecting and isolating circulating tumor cells including a conductive polymer to which an antibody and magnetic nanoparticles are bound, which enables circulating tumor cells from early cancer patients and various circulating tumor cell types to be effectively detected using a small amount of blood, circulating tumor cells to be monitored with the naked eye through colorimetric detection, and a very small amount of circulating tumor cells present in blood to be efficiently captured with a strong magnetic field generated by a large amount of the loaded magnetic nanoparticles; in detecting, isolating, and collecting the circulating tumor cells in a very small amount, a long nanowire structure and various antibody types are used, whereby contact with cancer cells may be increased and strong bonding may be formed; sensitivity is increased and various interactions with cancer cells are facilitated, thereby exhibiting increased detection and isolation effects.. .
National Cancer Center

Methods of screening using amphibians

High-throughput methods of screening agents for activities affecting renal, cardiac, blood or lymphatic vascular development and functions in amphibians in multiwell plates are provided. Also provided are novel compounds that modulate blood and lymphatic vascular development..

Sample fixation and stabilisation

It has surprisingly been discovered that it is possible to stabilise biomolecules such as rna, dna and proteins in biological samples such as cells, tissues, biopsies and blood using deep eutectic solvents (des). It has also been discovered that des mixtures can be used to fix and preserve cell morphology in biological samples such as tissue blocks, cancer biopsies and whole blood.
Rnassist Ltd.

Pump with external controlled compression and methods of pumping with external controlled compression

The present invention relates to pumps, particularly a compact, linear, positive displacement pump that can be used in several applications including medical and non-medical devices. In particular, the invention is related to linear, positive displacement compression blood pumps (either intracorporeal or extracorporeal) that provide systemic circulatory stability by maintaining a steady average blood pressure.
The Regents Of The University Of Colorado, A Body Corporate

Digital analysis of circulating tumor cells in blood samples

This disclosure relates to new assay methods for analysis of circulating tumor cells (ctcs) in blood samples for detection, e.g., early detection, and/or monitoring of disease, e.g., cancer. The methods provide ultra-high sensitivity and specificity, and include the use of microfluidic isolation of ctcs and digital detection of rna derived from the ctcs..
The General Hospital Corporation

Blood rna biomarkers of coronary artery disease

The present invention discloses a unique panel of gene transcripts down-regulated in patients with coronary artery disease (cad). Methods and compositions for detecting cad in patient blood samples are provided..
The George Washington University

Selective ultrasonic lysis of blood and other biological fluids and tissues

The present invention features methods for selective lysis of endogenous cells in a biological sample. In preferred embodiments, the methods of the invention comprise contacting the biological sample with lysis solution, and subjecting the mixture to ultrasound, thereby selectively lysing the endogenous cells in the biological sample.
Advandx, Inc.

Methods for treating an immune disorder-related disease by reducing autoreactivity in a t cell compartment

The described invention provides a pharmaceutical composition comprising a therapeutic amount of an educated mononuclear cell product, a process for preparing the educated mononuclear cell product, and a method for treating a disease characterized by lymphocyte autoreactivity. Mononuclear cells from a diseased subject are co-cultured with a viable population of adherent umbilical cord blood stem cells at at least 80% confluence to form an educated mononuclear cell product.
Hackensack University Medical Center

Methods for isolating and proliferating autologous cancer antigen-specific cd8+ t cells

Provided is a method for isolating and proliferating autologous cancer antigen-specific cd8+t cells, and more particularly, a method for selecting an epitope recognized by cd8+ t cells from autologous cancer antigens present in blood of individual cancer patients; and isolating autologous cancer antigen-specific cd8+ t cells by using a peptide of the selected epitope, and a method of massively proliferating cd8+ t cells by using the method. According to the present invention, it is possible to isolate autologous cancer antigen-specific cd8+ t cells by using the peptide of the cd8 t cell epitope of the autologous cancer antigen present in blood of individual cancer patients instead of a heterologous antigen.
National Cancer Center

Autologous somatic cell therapy, controllable preparation of therapeutic composition and procedure of adaptive treatment of ivf patient

A blood product containing peripheral blood mononuclear cells (pbmcs) in an amount of at least 4 million cells per milliliter and human chorionic gonadotropin (hcg in an amount of at least 150 international units (iu) per milliliter. A method of preparing the blood product, including applying hcg to a female patient, then obtaining pbmcs from the female patient, then adding hcg to the obtained pbmcs.
Progena Inc.

Development of spinal cord on a microfluidic chip

The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems..
Cedars-sinai Medical Center

Blood brain barrier transport molecules and uses thereof

The disclosure provides transporter molecules capable of carrying agents of interest across the blood brain barrier. Also provided are polynucleotides encoding transporter molecules, methods making transporter molecules, and methods of using transporter molecules, e.g., for the diagnosis, prevention, or treatment of central nervous system diseases, disorders, or injuries..
Medimmune Limited

Dicam-specific antibodies and uses thereof

Novel antibodies directed against dual ig domain containing cell adhesion molecule (dicam) are described. These anti-dicam antibodies are capable of detecting dicam by western blot and/or flow cytometry, blocking the interaction between dicam and its ligand αvβ3 integrin, and/or blocking the migration of inflammatory cytokine-secreting th17 lymphocytes across the blood brain barrier.
Centre Hospitalier De L'université De Montréal

Treating vascular disease and complications thereof

Administration of an antibody that specifically binds il-1α is useful for reducing the chance or severity of a major adverse clinical event occurring in a mammalian subject having received or expected to receive surgical treatment for a stenosed blood vessel, and for reducing the change of restenosis occurring (or increasing the time until restenosis occurs) in a mammalian subject having received or expected to receive surgical treatment for a stenosed blood vessel.. .
Xbiotech, Inc.

Fibroblast growth factor (fgf) 1 mutants and methods of use to reduce blood glucose

The present disclosure provides fgf1 mutant proteins, which include an n-terminal deletion, point mutation(s), or combinations thereof. In some examples, the mutant fgf1 proteins have reduced mitogenic activity.
Salk Institute For Biological Studies

Saxatilin-fc fusion protein and use thereof

The present invention relates to a saxatilin derivative having an increased half life and a use thereof. The saxatilin derivative of the present invention has thrombolytic ability similar to that of saxatilin, which is the mother protein, a remarkably increased protein half life, and efficiently dissolves, for long period of time, blood clots already formed in blood vessels of an animal model with a fecl3-induced carotid by using the same.
Industry-academic Cooperation Foundation, Yonsei University

Ang (1-7) derivative oligopeptides and methods for using and producing the same

The present invention provides oligopeptides, in particular, ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment..
Arizona Board Of Regents On Behalf Of The University Of Arizona

Synthesis and utility of new capgroup largazole analogs

Analogs of largazole are described herein. Methods of treating cancer, blood disorders, autoimmune disease, and alzheimer's disease using largazole analogs and pharmaceutical compositions comprising the same are additionally described herein.
University Of Notre Dame Du Lac

Apparatus and methods for treating hardened vascular lesions

An angioplasty catheter comprises a catheter body having a balloon or other radially expandable shell at its distal end. A non-axial external structure is carried over the shell and scores a stenosed region in a blood vessel when the balloon is inflated therein.
Angioscore, Inc.

Split tip catheter

The present disclosure relates to catheter assembly and components thereof. In one embodiment, a catheter assembly includes a catheter including a body with a proximal end and a distal end, wherein the body includes a first lumen and a second lumen.
Vascutech Medical Llc

Adapter for blood dispensing

A medicine-holding body is disposed in a flow path of a nozzle portion of an adapter for blood dispensing. The medicine-holding body is formed of a plurality of fibers which is made of polyester and is bundled by aligning a longitudinal direction thereof in a flowing direction which is a direction in which blood flows.
Fujifilm Corporation

Controlling an fluid transfer to and/or from a subject

A control system (23) is arranged to control the operation of an apparatus (200) for extracorporeal blood treatment. The apparatus (200) comprises an extracorporeal blood circuit (20) and a connection system (c) for connecting the blood circuit (20) to the vascular system of a patient.
Gambro Lundia Ab

Blood condition monitor, blood condition monitoring method, blood condition monitoring system, and blood condition improving program

Provided is a blood condition monitor using a permittivity-based coagulation measurement technology to monitor the condition of blood during extracorporeal circulation and thus being useful for avoiding blood problems from occurring during extracorporeal circulation. Provided is a blood condition monitor including: an extracorporeal circulation unit for extracorporeally circulating blood; and a first blood measurement unit for measuring an electrical characteristic of the blood obtained by applying an ac electric field to the blood.
Sony Corporation

Membrane for an oxygenator for gas exchange in the bloodstream, oxygenator having such a membrane, and producing such a membrane

The invention relates to an oxygenator for gas exchange in the bloodstream, comprising a housing, a first interior chamber for blood arranged in the housing, a second interior chamber for gas arranged in the housing, and a membrane separating the interior chambers. According to the invention, the membrane has a silicone layer and a reinforcing structure reinforcing the silicone layer..
Raumedic Ag

Enclosure for a portable hemodialysis system

An enclosure for containing a portable hemodialysis unit includes a housing suitable to support components for performing hemodialysis including a dialyzer, one or more pumps to circulate blood through the dialyzer, a source of dialysate, and one or more pumps to circulate the dialysate through the dialyzer. The housing may have a front panel at which blood circuit connections and dialysate fluidic connections are located, e.g., blood line connections for patient blood access, connections for a reagent supply, dialyzer connections for both blood flow and dialysate, etc.
Deka Products Limited Partnership

Prosthetic rib with integrated percutaneous connector for ventricular assist devices

A mechanical circulatory support system includes an implantable blood pump, an implantable prosthetic rib assembly, and an implantable drive cable. The prosthetic rib assembly includes a prosthetic rib segment and a percutaneous electrical connector mounted to the prosthetic rib segment.
Tc1 Llc

Cardiac pump implantation device and method

A system and method for implanting a ventricular assist device (“vad”) within the heart includes one or more tools, each having a tool body with a passage. Each tool body can be engaged with an anchor ring assembly secured to the heart.
Heartware, Inc.

Blood pump assembly and use thereof

The invention provides a blood pump for use with an intravascular ventricular assist system (ivas), as well as a method for utilizing the blood pump to treat heart failure.. .
Nupulsecv, Inc.

Anti-suction blood pump inlet

A heart pump assembly includes an impeller blade coupled to a rotor or a drive shaft, a cannula, a distal projection coupled to a distal end of the cannula and a blood inlet having a plurality of apertures. The plurality of apertures are radially oriented and disposed about a circumference of the cannula.
Abiomed, Inc.

Bioengineered allogeneic blood vessel

The present invention relates to methods for recellurization of blood vessels. This method is particularly useful for producing an allogeneic vein, wherein a donor vein is decellularized and then recellularized using whole blood or bone marrow stem cells.
Novahep Ab

Endonuclease targeting blood coagulation factor viii gene and composition for treating hemophilia comprising same

The present invention provides a method for inducing an inversion of normal blood coagulation factor viii (f8) gene, a method for correcting an inversion of blood coagulation factor viii gene in which the inversion has occurred, and a hemophilia a patient-derived induced pluripotent stem cell in which the inversion is corrected, constructed using the same. The method of the present invention effectively reproduces the inversion of intron 1 and intron 22 of the f8 gene, which is responsible for the majority of severe hemophilia a, and thereby may be effectively used for studying the development mechanism of hemophilia a and as a research tool for screening therapeutic agents.
Institute For Basic Science

Traditional chinese medicine composition for preventing and treating externally diabetes and a using the same

The invention discloses a traditional chinese medicine composition and a method thereof for preventing and treating externally diabetes, which is characterized in that the traditional chinese medicine composition is composed of astragalus membranaceus, salvia miltiorrhiza, stigma maydis, cortex lycii radicis, wolfberry, prunella vulgaris, mulberry leaf, cornus officinalis, lycopodium clavatum, the root of bidentate achyranthes, rhizoma chuanxiong, chinese atractylodes, yam, puerarin, fructus arctii, cassia twig; the method of use is to put a 40-50 g/ml medicine bags of the chinese herbal medicine powder or decoction into a foot pot, brew with boiling water, and then steam more than 10 minutes with the traditional chinese medicine steam after stirring evenly. When the water is cooled to 40-42° c., soaking feet once a day before going to bed, a course for foot soaking being 20 days; the contents of blood glucose and symptom of polydipsia, polyuria and polyphagia of the patients can be effectively reduced and disappeared by the foot bath in traditional chinese medicine, thus improving the immunity of the body and activating the autoimmunity as well as promoting the self-healing ability for the disease; and also such diseases as diabetic peripheral neuropathy (dpn), diabetic foot, diabetic nephropathy (dn), uremia caused by renal insufficiency resulted from diabetes can be prevented..

Composition for preventing or treating inflammatory diseases, comprising lactic acid bacteria-derived extracellular vesicles as active ingredients

Provided is a composition for preventing, ameliorating, or treating inflammatory diseases, the composition including, as active ingredients, lactic acid bacteria-derived extracellular vesicles isolated from culture fluid of lactic acid bacteria; and a method for diagnosing atopic dermatitis. The composition including the lactic acid bacteria-derived extracellular vesicles as active ingredients is expected to be usefully used in development of drugs, cosmetics, or health functional food for preventing, ameliorating, or treating inflammatory diseases such as atopic dermatitis, chronic rhinitis, chronic rhinosinusitis, asthma, chronic obstructive pulmonary disease, sepsis, etc.
Md Healthcare Inc.

Use of lactobacillus plantarum composition for manufacturing anti-fatigue probiotic composition for improve exercise performance

The present invention is directed to a use of anti-fatigue probiotic bacteria for improving exercise performance, particularly the fatigue caused by exercise. The anti-fatigue probiotic bacteria increases muscle mass and endurance, decreases blood lactate, ammonia, and creatine kinase concentration, and changes body composition; the said bacteria can be used to improve exercise performance..
National Taiwan Sport University

Compositions and methods for reprogramming adult cells through the stemness of a platelet rich fraction of blood containing platelet-like cells in humans

The described invention provides a method of functionally reprogramming adult cells to an immature cell type that expresses one or more embryonic biomarkers. The reprogramming is accomplished by contacting the adult cells with a platelet rich fraction comprising platelet-like cells from umbilical cord blood or peripheral blood, and expanding the immature cell type in vitro under culture conditions to generate an insulin-producing cell population that expresses human beta-cell specific transcription factors and is functionally equivalent to human pancreatic beta-cells.

Methods of therapeutic monitoring of nitrogen scavenging drugs

The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods that utilize this technique to adjust the dosage of a nitrogen scavenging drug, determine whether to administer a nitrogen scavenging drug, and treat nitrogen retention disorders.. .
Horizon Therapeutics, Llc

Rheological blood replacement solution and uses thereof

The present invention relates to a polymer solution for use as a rheological blood substitute. The rheological blood replacement solution comprises in its basic composition a water-soluble cellulose polymer with a molecular weight of 100 kda or greater, polyethylene oxide and a solvent.
Universitätsmedizin Der Johannes Gutenberg- Universtät Mainz

Multiple lumen heat exchange catheters

Catheter devices and methods for intravascular heating and/or cooling of human or veterinary patients. The catheter devices generally comprise catheters having inflow and outflow lumens and at least one curvilinear balloon connected to the inflow and outflow lumens such that heat exchange fluid may be circulated through the balloon(s).
Zoll Circulation, Inc.

Apparatus for treating erectile dysfunction and enhancing penile enlargement

An apparatus for enhancing erection of a penis includes an expandable first member that partially encircles an upper portion of the penis and partially constricts at least a first vein of the penis to reduce the volume of blood carried away from the penis via the first vein. A second member is mounted to the first member includes left and right shoulder sections configured to contact the penis shaft along the left and right sides the urethra.

Heart valve prosthesis and separate support flange for attachment thereto

A valve prosthesis assembly for implantation into a native valve site. The valve prosthesis assembly includes a valve prosthesis with a prosthetic valve component and a frame.
Medtronic Vascular, Inc.

Perivalvular occlusion device and methods

An occlusion device intended for blocking perivalvular leak channels that are found following heart valve implantation between the heart valve and the surrounding tissue. The occlusion device has a stent and a covering that is attached to the stent surface.

Great vessel graft suturing aid

A stabilization tool supports a blood vessel for suturing during cardiovascular surgery. The support vessel may typically be part of an artificial graft used in replacing an aortic arch.
Terumo Cardiovascular Systems Corporation

Axial lengthening thrombus capture system

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (pe), deep vein thrombosis (dvt), cerebrovascular embolism, and other vascular occlusions.. .
Kp Medcure, Inc.

Vena cava filter with dual retrieval

An intravascular filter assembly has an expanded state for capturing thrombi in a patient's blood vessel, a first a collapsed state for removal from the patient's blood vessel in a first direction and a second collapsed state for removal from the patient's blood vessel in a second direction. A plurality of first struts extends from a first axial side of a fixed hub, and a plurality of second struts extends from the opposite axial side of the fixed hub.
Cook Medical Technologies Llc

Method and system for image processing to determine blood flow

Systems and methods are disclosed for evaluating cardiovascular treatment options for a patient. One method includes creating a three-dimensional model representing a portion of the patient's heart based on patient-specific data regarding a geometry of the patient's heart or vasculature; and for a plurality of treatment options for the patient's heart or vasculature, modifying at least one of the three-dimensional model and a reduced order model based on the three-dimensional model.
Heartflow, Inc.

Apparatus and intra-cardiac mapping and ablation

An intra-cardiac mapping system is based on locating the ports through which blood flows in or out the heart chambers. For many procedures, such as ablation to cure atrial fibrillation, locating the pulmonary veins and the mitral valve accurately allows to perform a maze procedure.
Kardium Inc.

Vascular closure device

A vascular closure system is configured to seal an incision in a vessel of the patient's body. The system includes a slider that is moved from an initial position to a deployed position (that is, towards the puncture of the patient body), until the proximal end of the slider exposes a reference marker on an inner tube.
Meril Life Sciences Pvt. Ltd.

Medical imaging device and medical image processing method

A method of processing a medical image includes acquiring a three-dimensional (3d) medical image indicating a blood vessel and a two-dimensional (2d) medical image indicating the blood vessel, determining a blood vessel area in the 3d medical image corresponding to a partial area of the blood vessel in the 2d medical image, and matching the blood vessel area with the partial area in the 2d medical image.. .
Seoul National University R&db Foundation

System and health monitoring including a user device and biosensor

A biosensor unit is coupled to a user device and may communicate with the user device over a short range wireless or wired interface. The biosensor unit includes an optical sensor used to obtain an oxygen saturation level, a heart rate and a respiration rate of a user.
Sanmina Corporation

Blood glucose monitoring device

A blood glucose monitoring device includes a container, blood glucose test strips and a glucometer. The container includes a body and a cap.

System for withdrawing blood

The present invention includes a system for withdrawing body fluids. The system includes a drive unit having a plunger which is moved from a resting position into a lancing position in order to carry out a lancing process and a lancing unit containing a lancet with a needle.
Roche Diabetes Care, Inc.

Hypersaturation index

Embodiments of the present disclosure provide a hypersaturation index for measuring a patient's absorption of oxygen in the blood stream after a patient has reached 100% oxygen saturation. This hypersaturation index provides an indication of the partial pressure of oxygen of a patient.
Masimo Corporation

Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector, which includes a preamplifier having a feedback resistor, positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, and a processor configured to receive the output signal from the at least one light detector and based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area and elimin