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Blood patents

      

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Wearable health monitors and methods of monitoring health
Wearable technologies, such as wearable health monitors, and methods of use are provided. In some embodiments, the wearable technology can be worn at the wrist of an individual and can use an accelerometer, pulse oximeter, and electrocardiogram to measure heart rate, oxygen saturation, blood pressure, pulse wave velocity, and activity.

Blood treatment device
The present invention relates to a blood treatment device having at least one reading and/or writing apparatus which is configured to read information from a card and/or to write information to a card, and having at least one receiver into which the card can be introduced and from which the card can be removed, wherein the receiver is arranged such that information can be read from the card and/or information can be written to the card by means of the reading and/or writing apparatus in the state of the card introduced into the receiver, wherein the receiver is not horizontal, but rather extends slanted upwardly with respect to the horizontal in the direction of introduction of the card.. .

Wearable partial task surgical simulator
A wearable device for simulating wounds and injuries received during a trauma event includes a raiment and vest for covering the torso of a person. The raiment has an outer surface with a color and a texture comparable to human skin.

Medical image processing apparatus, medical image processing method, and medical image processing program
The medical image processing apparatus includes a medical image acquisition unit that acquires a medical image; and a lesion detection unit that detects a lesion region in the medical image. The lesion detection unit includes a first identifier that identifies a lesion region candidate in the medical image and a second identifier that identifies whether the lesion region candidate identified by the first identifier is a blood vessel region, and detects the lesion region candidate that is not identified as the blood vessel region by the second identifier as the lesion region..

Finger vein identification
A finger vein identification method and device used for effectively extracting finger vein identification characteristics to conduct finger vein identification. The method of the embodiments of the present teachings comprises: collecting a finger vein image, employing a line fitting method to extract a region of interest in the finger vein image, conducting geometric normalization and grayscale normalization processing of the region of interest to obtain a processed region, determining finger vein blood vessel lines in the processed region to obtain a finger vein blood vessel image, and conducting finger vein identification based on the finger vein blood vessel image..

Accurate measurement of glutathione for disease diagnosis and drug metabolite screening
A method of measuring and calculating (preferably by a computer with output to a user) tgsh (total glutathione very particularly defined) with sample preparation and assay methods that have been confirmed to provide accurate and reliable tgsh and related diagnostic assays in blood or tissue from a patient.. .

Methods and tools for vel blood group typing
The present invention relates to methods and tools for discriminating between vel negative and vel positive phenotypes. The invention is thus useful for determining vel blood group status of individuals about to receive blood transfusion..

Methods and segregation of particles
The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are accommodated in a passage bounded by a first step, but at least some of the particles are unable to pass through a narrower passage bounded by a second step, resulting in segregation of the particles.

Light scatter based hematology analysis using only three detectors
Disclosed herein are apparatus, systems, and methods for optically identifying and enumerating cells present in a blood sample. A light scatter detector array may be used having no more than three light scatter detectors.

Method, apparatus and micro-rheometer for measuring rheological properties of newtonian and non-newtonian fluids

Apparatus comprising a micro-rheometer (1) with a microchannel (2) and a sensor array arranged along the microchannel to measure rheological properties of a fluid. The sensor array comprises a plurality of pairs of electrodes (8, 8′), each pair being placed face to face to function as an electronic switch when the fluid flows through them.

Compositions and methods for a three dimensional ex-vivo glomerular cell co-culture biological engineering model

The invention provides compositions, methods and systems for the ex vivo co-culture of renal cells, more specifically, for the co-culture of glomerulus-derived vascular endothelial cells and podocyte cells using apparatus that mimics the in vivo cellular architecture of the renal corpuscle. The invention described herein finds a variety of uses, for example, as a model system for the study of renal corpuscle function, including the filtration of the blood supply that occurs at the interface of the glomerulus and bowman's capsule, normal physiology of those cell types, and as a model system for the study of renal disease, including the study of drug effects on the functioning of these cell types..

Systems for detecting, monitoring or treating diseases or conditions using engineered cells and methods for making and using them

Provided are methods for detecting and treating disease states, including cancer, diabetes, fibrosis, and autoimmune diseases, by detecting increased mechanical modulus, or stiffness, or targeting tissues having increased mechanical modulus, or stiffness. Practicing these methods provides specific and localized detection assays and therapies for these disease states.

Microfluidic model of the blood brain barrier

The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems..

Microfluidic model of the blood brain barrier

The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems..

Slippery liquid-infused porous surfaces and biological applications thereof

A self-healing, scratch resistant slippery surface that is manufactured by wicking a chemically-inert, high-density liquid coating over a roughened solid surface featuring micro and nanoscale topographies is described. Such a slippery surface shows anti-wetting properties, as well as exhibits significant reduction of adhesion of a broad range of biological materials, including particles in suspension or solution.

Device including multilayer membrane to control fluid drainage and methods of use thereof

A device and methods are disclosed herein for fluid removal during wound treatment or for removal or dialysis of components from blood or tissue. A device is disclosed that includes a multilayer membrane including a plurality of layers; an electroactive polymer within each layer; and a controller operably connected to sequentially activate the electroactive polymer to alter one or more sizes of the plurality of the variably-sized pores within one or more layers of the multilayer membrane.

Methods and power conversion and data transmission in implantable sensors, stimulators, and actuators

Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters.

Wearable medical system monitoring blood-related parameter

A wearable medical system includes a support structure with one or more electrodes in an unbiased state. A monitoring device monitors, for the long term, a blood-related parameter of the person.

Transvascular nerve stimulation apparatus and methods

Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues.

Intubation device with variable backflow pressure

Intubation devices, systems, and methods in which the risk of leakage of nasopharyngeal secretions, esophageal reflux, and blood is reduced, or eliminated, by means of a backflow pressure gradient that is independent of peep. Contemplated configurations include (a) a flexible tube for the controlled delivery of air and other gases to the lungs, (b) distal and proximal inflatable seals that can close the annular space surrounding the tube, (c) means to inflate the seals, and (d) means to deliver gas under pressure to the annular chamber in between the two seals.

Platelet rich plasma and bone marrow aspirate cell separation and removal methods and devices

Compositions and methods for separating a sample of whole blood or bone marrow aspirate into a fraction rich in at least one of platelets and pluripotent cells are provided. A sample of whole blood can be centrifuged in a collection tube comprising a separator substance formulated to settle between the prp fraction and the at least one other fraction.

Cardiac function measuring system and extracorporeal circulator provided with cardiac function measuring system

A cardiac function measuring system 200 includes a flowmeter 70 that measures a flow rate waveform of blood from a human body while the blood is circulating outside the body in an extracorporeal circulator. A control unit 100 acquires a pulsation waveform 62 (waveform 60) which is a flow rate fluctuation waveform of blood included in a flow rate waveform measured by the flowmeter 70.

Systems and methods for detecting vascular access disconnection

A system for detecting whether a vascular access has been interrupted in an arrangement in which two catheters or needles are present in a blood vessel, fistula or graft. A fluid line leading to a pump is connected via a first connector to a first indwelling catheter, and a fluid line leading from a pump is connected via a second connector to a second indwelling catheter.

Device and generating a filtered pressure signal

A signal filtering device acquires one or more pressure signals that comprise first pulses originating from a first pulse generator associated with a fluid containing system and second pulses. The signal filtering device populates (504) signal vectors by signal segments in the pressure signal(s) and computes (505) principal components for the signal vectors by principal component analysis (pca).

Device and disruption detection

A monitoring device detects a disruption of a fluid connection between first and second fluid containing systems using one or more pressure sensors arranged in the first fluid containing system to detect first pulses from the first fluid containing system and second pulses from the second fluid containing system. The monitoring device receives (501) pressure signal(s) from the pressure sensor(s), populates (504) signal vectors by signal segments in the pressure signal(s) and computes (505) one or more eigenvectors and/or one or more eigenvalues for the signal vectors by a source separation algorithm.

Catheter-based heart support system and implanting thereof

A device for circulatory support of the heart with holding means implanted intracardially in the left or right ventricular outflow of the heart by catheter, using an endovascular method, through a femoral access or a percutaneous transventricular, transseptal, transapical or transvenous access, the holding means comprises anchoring means fixed in the subcommissural triangle underneath the aortic valve and the pulmonary valve, in the flow direction of the blood on the ventricular side of the aortic valve and the pulmonary valve, a pump fixed in the holding means by a catheter, using an endovascular method, through a femoral access or a percutaneous transventricular, transseptal, transapical or transvenous access, the pump can be inserted releasably into the holding means after the holding means has been fixed by the anchoring means in the subcommissural triangles underneath the aortic valve and the pulmonary valve, or is connected to the collapsible and expandable anchoring means.. .

Sheet of biological tissue, tubular structure obtained from said sheet, and artificial blood vessel comprising said tubular structure

A sheet of biological tissue which includes on at least one side tapered edge portion thinning down in the thickness direction, towards an end thereof, a tubular structure obtained from the sheet, and an artificial blood vessel made up of the tubular structure are provided.. .

Adenovirus complex for gene delivery and gene therapy

The present invention relates to an adenovirus complex which can be utilized for gene delivery and gene therapy by targeting neurotensin receptors. The complex of the present invention has an excellent antitumor effect because of a high intracellular gene transfer efficiency and target specificity by neurotensin receptor-specific binding, has little hepatotoxicity and immunogenicity, forms a stable complex, has low immunogenicity, and thus has a low loss in blood even in an in vivo environment.

Preparations of rosa laevigata fruit extracts and uses thereof for regulation of cd36, apoa1, and srb1

Provided is a method of a method of preparing a rosa laevigata fruit extract which regulates cd36, apoa1, and srb1, including extracting the fruit of rosa laevigata using water, alcohols, or mixtures of water and alcohols as solvents. Also provided is a method of regulating cd36, apoa1, and srb1, including administering to a subject a composition containing an effective amount of the rosa laevigata fruit extract.

Traditional chinese medicine composition having a function of regulating emotion, a process for preparing the same, and a product thereof

The present invention relates to the technical field of health-care product, and in particular relates to a traditional chinese medicine composition having a function of regulating emotions, a process for preparing the same, and a product thereof. It was found that the composition of the present invention had effects of nourishing liver and kidney, regulating yin and yang, tonifying qi and nourishing blood, regulating emotions, and protecting the function of autonomic nerve, and could improve pressure-induced anxiety and depression, inattention, poor spirit, dispirited, learning and memory capacity decline, etc.

Pharmaceutical composition or functional health food for preventing and treating metabolic diseases, containing water extract of pleurotus eryngii var. ferulae (pf.) as active ingredient

The present invention relates to a composition for preventing and treating metabolic disorders, containing a water extract of pleurotus eryngii var. Ferulea (pf) as an active ingredient, wherein the water extract of pleurotus eryngii var.

Mapc treatmentof brain injuries and diseases

The invention relates to the treatment of various injuries, disorders, dysfunctions, diseases, and the like of the brain with mapcs, particularly in some aspects, to the treatment of the same resulting from hypoxia, including that caused by systemic hypoxia and that caused by insufficient blood supply. In some further particulars the invention relates, for example, to the treatment of hypoxic ischemic brain injury with mapcs, in children for example, and to the treatment of cortical infarcts and stroke with mapcs in adults, for example..

Soluble dietary fiber and preparation method thereof

A soluble dietary fiber having a xylooligosaccharide purity of 70% or greater. The xylooligosaccharide has a total xylobiose and xylotriose content of 45% or great.

Method of treating and preventing secondary hyperparathyroidism

The method of treating elevated blood levels of ipth by increasing or maintaining blood concentrations of both 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d in a patient by administering, as necessary, both vitamin d repletion and vitamin d hormone replacement therapies, is disclosed. The blood concentrations of 25-hydroxyvitamin d are increased to and maintained at or above 30 ng/ml, and blood concentrations of 1,25-dihydroxyvitamin d are increased to or maintained within a patient's normal historical physiological range for 1,25-dihydroxyvitamin d without causing substantially increased risk of hypercalcemia, hyperphosphatemia or over suppression of plasma ipth in the patient.

Cobalt porphyrins for the treatment of blood-related disorders

The use of cobalt porphyrins for the manufacture of an agent for mobilizing bone marrow cells to peripheral blood, preferably used to treat congenital neutropenia, for the treatment and prevention of neutropenia caused by chemotherapy, radiotherapy and pharmacologically-induced neutropenia, for the treatment of acute myeloid leukemia, acute lymphocytic leukemia, myelodysplastic syndromes, and to increase the amount of circulating hematopoietic stem cells in peripheral blood for subsequent isolation in the process of apheresis and allogeneic or autologous transplantation.. .

Liposome and liposome composition

An object of the present invention is to provide a liposome and a liposome composition in which release of a drug in blood is suppressed during accumulation of the liposome and the liposome composition in a target site such as a tumor and the drug is rapidly removed after the liposome and the liposome composition are sufficiently accumulated. According to the present invention, there is provided a liposome containing at least a phospholipid to which a hydrophilic polymer is bonded, a phospholipid having a negative charge within a range of a ph of 6 to 8, and a phospholipid which is electrically neutral within a range of a ph of 6 to 8, in which an average carbon chain length of the phospholipid to which the above-described hydrophilic polymer is bonded is shorter than an average carbon chain length of the above-described phospholipid which is electrically neutral within a range of a ph of 6 to 8..

Microvesicles derived from nucleated, mammalian cells and use thereof

The present invention relates to a microvesicle that is derived from nucleated mammalian cells, which are smaller than the nucleated cells. The microvesicles of the present invention can be used in the delivery of a therapeutic or diagnostic substance to specific tissues or cells, and more particularly, relates to microvesicles derived from monocytes, macrophages, dendritic cells, stem cells or the like, which can be used to deliver specific therapeutic or diagnostic substances for treating and/or diagnosing tissue associated with cancer, diseased blood vessels, inflammation, or the like..

Acoustic shock wave therapeutic methods

A method of modulating glandular secretions by administering acoustic shock waves to a reflexology zone or region has been discovered. In one preferred embodiment, a treatment method achieves one or more of a) modulating blood sugar levels, b) stimulating insulin production levels or c) normalizing a1c levels by using the step of administering acoustic shock waves to a reflexology zone or region.

Axial lengthening thrombus capture system

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (pe), deep vein thrombosis (dvt), cerebrovascular embolism, and other vascular occlusions.. .

Robotic systems providing co-registration using natural fiducials and related methods

A method may be provided to operate a medical system. First data may be provided for a first 3-dimensional (3d) image scan of an anatomical volume, with the first data identifying a blood vessel node in a first coordinate system for the first 3d image scan.

Electrosurgical instrument for radiating microwave energy and dispensing liquid at a treatment site

An electrosurgical device capable of both: (i) generating a radiative microwave field to perform either blood coagulation or sterilization, and (ii) dispensing a liquid to a target area, e.g. Adrenaline for the treatment of peptic ulcers.

Methods and treating embolism

A method and apparatus for treating a clot in the blood vessel of a patient, and particularly the treatment of a pulmonary embolism is disclosed. The treatment includes restoring flow through the clot followed by clot removal, either partially or substantially completely.

Ultrasonic surgical shears and sealing a blood bessel using same

An ultrasonic surgical shears includes an ultrasonic surgical blade, a clamping arm operable to open and close toward the blade, and a tissue pad attached to the clamping arm. A method for sealing a blood vessel of a patient includes obtaining an ultrasonic surgical shears and positioning the blood vessel between the blade and the tissue pad.

Aspiration catheter

The invention relates to an aspiration catheter for the aspiration of material from blood vessels. The aspiration catheter according to the invention comprises a tubular catheter wall (2) having a first distal opening (3) and a first proximal opening (4).

Selectively delivering particles into the distal portion of the left gastric artery

Methods and apparatuses for embolizing an artery in a living subject using a catheter are disclosed. The catheter has a lumen and also has a balloon located near the distal end of the catheter.

Medical image processing apparatus and x-ray ct apparatus

A medical image processing apparatus according to an embodiment includes processing circuitry. The processing circuitry sets a first region of interest in a region corresponding to cardiac muscle on a cross-section of a heart included in image data.

Altering physiological signals based on patient movement

This document describes ways in which to alter physiological signals to address corrupt, noisy, or otherwise faulty data. By so doing, accuracy and robustness in sensing and assessing a patient's cardiovascular health can be improved.

Systems and methods for coordinating musculoskeletal and cardiovascular hemodynamics

Described herein are systems and methods for favorably coordinating a timing relationship between a musculoskeletal activity cycle and a cardiac cycle of a user. A method may include repetitively detecting a signal that correlates to a blood volume in the user; determining an actual value of the signal that varies with the timing relationship; computing a trend of the actual value of the signal; and adjusting the movement guidance based on the trend of the actual value.

Biological fluid collection device and biological fluid separation and testing system

A biological fluid collection device that is adapted to receive a blood sample having a cellular portion and a plasma portion is disclosed. After collecting the blood sample, the biological fluid collection device is able to transfer the blood sample to a point-of-care testing device or a biological fluid separation and testing device.

Non-invasive blood pressure measurement

A method of measuring a patient's blood pressure non-invasively considers the shape of the waveform to accurately estimate the patient's invasive systolic and diastolic blood pressure, or alternatively accurately predict the patient's hypertension classification. The method can be implemented in a clinical setting or within a wearable device..

System and rapid examination of vasculature and particulate flow using laser speckle contrast imaging

Examination of the structure and function of blood vessels is an important means of monitoring the health of a subject. Such examination can be important for disease diagnoses, monitoring specific physiologies over the short- or long-term, and scientific research.

Method for estimating a quantity of a blood component in a fluid receiver and corresponding error

A method and system for communicating estimated blood loss parameters of a patient to a user, the method comprising: receiving data representative of an image, of a fluid receiver; automatically detecting a region within the image associated with a volume of fluid received at the fluid receiver, the volume of fluid including a blood component; calculating an estimated amount of the blood component present in the volume of fluid based upon a color parameter represented in the region, and determining a bias error associated with the estimated amount of the blood component; updating an analysis of an aggregate amount of the blood component and an aggregate bias error associated with blood loss of the patient, based upon the estimated amount of the blood component and the bias error; and providing information from the analysis of the aggregate amount of the blood component and the aggregate bias error, to the user.. .

Electronic blood pressure monitor

An electronic blood pressure monitor of the present invention includes a blood pressure measurement cuff that is to be worn on a measurement site of a measurement subject. The electronic blood pressure monitor includes a blood pressure measurement unit that measures a blood pressure value of the measurement subject using the cuff.

Apparatus for characterizing a vessel wall

The invention presents an apparatus (6) for characterization of a condition of a vessel (12) wall of a living being (2). The relationship between temporal blood pressure (621) and blood flow (622) measurements of pulsatile blood motion within the vessel (12) is an indication of the health of the vessel (12) wall.

System for characterization, diagnosis, and treatment of a health condition of a patient and methods of using same

A system integrating a hemodynamic parameter (hdp) monitoring system and a radiofrequency generator synchronized by a processing system is disclosed. The system is capable of identifying health condition-specific hdp variation values changes in a patient upon the exposure of low energy amplitude modulated electromagnetic fields frequencies (sfq).

Physiological measurement device using leds

A wearable device includes a measurement device adapted to be placed on a wrist or ear having a light source with leds to measure physiological parameters. The measurement device generates an optical beam having a near infrared wavelength between 700-2500 nanometers by modulating the leds, and lenses to deliver the beam to tissue, which reflects the beam to a receiver having spectral filters in front of spatially separated detectors coupled to analog to digital converters that generate at least two receiver outputs.

Measurement system with voice recognition

A system includes a measurement apparatus having sensors measuring physiologic parameters such as blood pressure, heart rate, and/or blood oxygen level. A sensor is inserted into a user orifice and coupled to tissue comprising blood.

Apparatus and diagnosing vessel occlusion

Apparatus and methods for diagnosing conditions consistent with the presence of cranial blood vessel blockage and large vessel occlusions (lvo's) using the framework of a small head-harness that is transportable, field-expedient, and durable. A single pulse set using ultrasonic or near-infrared energy is broadcast into a patient's brain allowing the apparatus to perform an area scan of the brain and detect and decipher cranial blood vessel blockage and lvo signal patterns.

Method for suppression of or protection from ischemia/reperfusion injury of organs for transplantation

The present application provides a method for preventing or protecting an organ from ischemia-reperfusion injury, the method comprising a step of perfusing an organ harvested for transplant ex vivo with a solution containing molecular hydrogen via a blood vessel thereof.. .

Automated blood safety workflow verification and validation

A method of using temporal logic technique to verify and validate blood safety workflows, the method includes creating a model workflow of blood supply chain process, wherein humans and machines are included as workflow constructs where involved, translating regulations governing blood safety into statements in temporal logic formula, wherein components satisfying a temporal logic formula correspond to satisfying the translated regulation, combining the translated regulations with the created blood supply chain model workflow, and validating that all translated regulations have been satisfied using a theorem prover.. .

Blood and saliva biomarker optimized food consumption and delivery with artificial intelligence

A computer implemented method for use in conjunction with a computing device, system, network, and cloud with touch screen two dimension display or augmented/mixed reality three dimension display comprising: obtaining, analyzing and detecting user blood and saliva chemistry data and mapping the blood and saliva data into a database associated with a specific user, applying the data with optimization equations and mapping equations to food chemistry such that a user may order food and beverage from a food/beverage distribution point or have food/beverage delivered to the user which has been specifically optimized for their specific blood characteristic target ranges. The method and system uses recursive techniques and neural networks to learn how to optimize food and beverage nutrient efficiency into the users blood chemistry..

Method and instrument for processing sample carrier cards

An instrument for processing sample carrier cards is described. Each sample carrier card contains impregnated sample material, e.g.

S100a9 levels for predicting lenalidomide and erythropoietin responsiveness

A method is disclosed for diagnosing multiple myeloma or myelodysplastic syndrome (mds) in a subject and/or predicting the responsiveness of a patient with a multiple myeloma or mds to lenalidomide treatment, erythropoietin treatment, or a combination thereof. The method involves assaying a biological sample from the subject, such as a blood, serum, or plasma sample, for s100a9 protein levels, tnf? levels, or a combination thereof wherein elevated levels of s100a9 in the biological sample and/or reduced levels of tnf? levels is an indication of mds in the subject and/or that the patient will be responsive..

Preparation of fetal nucleated red blood cells (nrbcs) for diagnostic testing

The disclosure relates to methods of preparation of fetal nucleated red blood cells (nrbcs) from biological samples for diagnostic testing.. .

Sample depletion and enrichment to improve the quality of diagnostic test results

Magnetic and non-magnetic microparticle binding surfaces for the simple, cost-effective and automatable depletion of sample interferences within the assay blocking threshold and enrichment of biomarkers are provided, as are methods and compositions for their preparation and use. The binding surfaces may comprise non-magnetic, magnetic, paramagnetic, and superparamagnetic microparticles, or combinations thereof.

Portable insulin resistance diagnosis device and diagnosis method using same

A portable insulin resistance diagnosis device includes: a housing capable of being grasped by an outer periphery thereof and comprising a space formed therein; a sensor unit which protrudes towards the outside of the housing and detects glucose and proteins in blood when a blood sample of a target specimen is dropped on the sensor unit, a diagnosis unit, which is provided inside the housing, amplifying an electrical signal generated according to concentrations of the blood glucose and proteins detected in the sensor unit, converting the electrical signal into a digital signal, and determining whether insulin resistance is normal; and a display unit, which is provided on an external surface of the housing, displaying whether insulin resistance analyzed in the diagnosis unit is normal.. .

Method for determining volume and hemoglobin content of individual red blood cells

Provided herein is a method for determining the volume or hemoglobin content of an individual red blood cell in a sample containing a population of red blood cells. The method may be performed on a hematology analyzer.

Gamma sterilized dextran solutions and methods of use

Provided herein are kit for providing a gamma sterilized aqueous dextran solution that increase the efficiency of blood separation by allowing the dextran solution to be sterilized by exposure to gamma radiation while maintaining sufficient molecular weight to act as a red blood cell aggregate. Also provided are methods of use..

Method for identifying the quantitative cellular composition in a biological sample

The present invention provides an epigenetic haemogram, also referred to as an epigenetic blood cell count that identifies the quantitative, comprehensive picture of cellular composition in a biological sample, wherein advantageously a normalization standard is used. The normalization standard is a nucleic acid molecule comprising at least one marker-region being specific for each of the blood cells to be detected, and at least one control-region being cell-unspecific, wherein said regions are present in the same number of copies on said molecule and/or a natural blood cell sample of known composition.

Reagents and methods for the analysis of linked nucleic acids

Reagents and methods for the analysis of nucleic acids (e.g. Genomic dna) of circulating microparticles (i.e.

Blood brain barrier opening agents and uses thereof

Among the various aspects of the present disclosure is the provision of a blood brain barrier (bbb) opening agent and uses thereof. An aspect of the present disclosure provides for methods of opening up the bbb; increasing the permeability of the tricellular junction; and using a bbb opening agent for the treatment of a brain pathology or neurological disease, disorder, or condition..

Inhibitors of micrornas mir-155, mir-103, mir-105 and mir-107 that regulate production of atrial natriuretic peptide (anp) as therapeutics and uses thereof

Provided herein are methods, kits and compositions to increase anp levels in a subject for the treatment of hypertension and/or cardiovascular diseases, comprising at least one anti-mir agent that inhibits at least one of, or a combination of mir-103, mir-105, mir-107 and/or mir-155, alone, or in combination with an inhibitor of mir-425. Anti-mir agents can be small molecules or an oligonucleotide complementary to at least part of the sequence of hsa-mir-103, hsa-mir-105, hsa-mir-107 and/or hsa-mir-155, or their respective seed sequences or.their binding site in the 3′utr of nppa gene.

Production of red blood cells and platelets from stem cells

This disclosure provides methods of making a megakaryocyte-erythroid progenitor cell (mep), comprising differentiating a mep precursor cell into a mep in culture in the presence of an aryl hydrocarbon receptor (ahr) modulator. In some embodiments the ahr modulator is an ahr antagonist.

Method of manufacturing and purifying exosomes from non-terminally differentiated cells

The present invention discloses a high volume manufacturing process for the production and purification of exosomes. In one embodiment, a hollow fiber perfusion reactor is used to expand stem cells.

Multiwell culture devices with perfusion and oxygen control

A microfluidic structure is formed with one or more microfluidic channels for receiving fluid and passing the fluid through a channel in communication with a collection chamber integrated with that channel through a transition stage that allows the collection chamber to gather targets within the fluid, such as cells, including circulating tumor cells in blood. The transition stage may be formed for an asymmetrical configuration with an obstacle and chamfered face configuration.

Trispecific antibodies specific for her2 and a blood brain barrier receptor and methods of use

The present invention relates to trispecific antibodies binding to her2 and a blood-brain barrier receptor (bbb-r), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.. .

Vascular access device

A system and method are provided for vascular access, enabling repetitive vascular access while preventing damage to the blood vessel wall, reducing hematomas, improving flow in a vessel, preventing back-wall perforation, and enabling improved fistula maturation and care. The system includes an implanted conduit that is incorporated into surrounding fibrous tissue that can guide a needle and/or catheter from a puncture site on the skin to a vessel wall, which may be used to provide repetitive vascular access for persons requiring hemodialysis or chemotherapy..

Balloon catheter

A balloon catheter includes an inner shaft with a distal variant portion and a proximal variant portion. A bulged portion is provided at the distal end of a reinforcement member, and the bulged portion is configured to move in an axial direction between the distal variant portion and the proximal variant portion.

Blood circulation system

Disclosed is an artificial heart and lung apparatus (100) that can be connected to a patient (p), and transfers removed blood to a human body via a roller pump (120), the system including: the roller pump (120); a blood removal line (101) which transfers removed blood to the roller pump (120); a first blood transfer line (104) that transfers blood, which is transferred from the roller pump (120), to the human body; a blood removal rate sensor (111) that is provided in the blood removal line (101); and a control unit (140), in which the control unit (140) performs control such that a blood transfer rate of the roller pump (120) is in a specific range with respect to a blood removal rate measured by a blood removal rate sensor (111).. .

Methods and systems for establishing retrograde carotid arterial blood flow

Interventional procedures on the carotid arteries are performed through a transcervical access while retrograde blood flow is established from the internal carotid artery to a venous or external location. A system for use in accessing and treating a carotid artery includes an arterial access device, a shunt fluidly connected to the arterial access device, and a flow control assembly coupled to the shunt and adapted to regulate blood flow through the shunt between at least a first blood flow state and at least a second blood flow state.

Optical detection of air bubbles in either saline or blood or a mixture of both

Embodiments of the disclosure provide a system and method for detection of a transient air bubble in an arterial blood flow path during dialysis (e.g., hemodialysis). The system uses measurements from an optical sensor to remove one or more effects of common factors affecting the absorbance of the light incident on the arterial tubing.

Renal failure therapy electrically safe treatment

A renal failure therapy system (10) includes a dialyzer (102); a blood circuit (100) in fluid communication with the dialyzer (102); a dialysis fluid circuit (30) in fluid communication with the dialyzer (102); a housing supporting the dialyzer (102), the blood circuit (100) and the dialysis fluid circuit (30); and at least one electrical socket (170) held by the housing, the electrical socket (170) providing a voltage output dedicated to a particular voltage type of external electrical device (200) for powering or charging the external electrical device (200), the at least one electrical socket (170) including electrical insulation for protecting a patient while powering the external electrical device (200).. .

Surgical punch

A cutting edge of a punch includes side segments and a central segment disposed between the side segments. When the punch head slides into a hollow blade, the central segment of the cutting edge meets the punch head before the side segments meet the punch head.

Fluid management apparatus and method

In one example embodiment, a vibration apparatus can augment and enhance negative-pressure therapy systems. The apparatus can be attached to an external surface of a dressing, fluid conductor, or other components.

Medical base material

Provided is a medical base material that is suitable for regeneration of a cardiovascular system being exposed to high pressure from a lumen, such as an aorta and is absorbed by a living body after transplantation. The medical base material of the present invention has a sheet shape, a tube shape, or a combined shape thereof and is used for regeneration of a cardiovascular system by being transplanted in a body.

Method for evaluating hematological toxicity of drug under evaluation, and model for evaluating hematological toxicity of drug under evaluation

The method for evaluating the hematotoxicity of the drug to be evaluated, the method including: administering the drug to be evaluated to humanized, transgenic nog mouse, which is obtained by introducing human gm-csf/il-3 gene into nog mouse and the number of human-derived leucocytes in leucocytes in blood thereof is 20% or more; and evaluating that the drug to be evaluated has the hematotoxicity when sample of the humanized, transgenic nog mouse after the administering the drug to be evaluated is measured for number of cells of human-derived hemocytes, the number of the cells of the human-derived hemocytes is changed compared to control to which vehicle is administered instead of the drug to be evaluated.. .

Compositions and methods for the depletion of cd137+ cells

The invention provides methods of preventing and treating graft-versus-host-disease and autoimmune diseases, such as those arising from transplant therapy, by selective depletion of hematopoietic cells through the use of antibody-drug conjugates and ligand-drug conjugates that specifically bind cd137. The compositions and methods described herein can be used to treat a variety of pathologies, including stem cell disorders and other blood conditions..

Spore-based probiotic composition for reduction of dietary endotoxemia and related methods

A method of treating metabolic endotoxemia comprising identifying a subject having post-prandial dietary endotoxemia and administering an effective amount of a spore-based probiotic. While any spore-based probiotic may be used, the probiotic supplement may comprise bacillus indicus (hu36), bacillus subtilis (hu58), bacillus coagulans, bacillus licheniformis, and bacillus clausii.

Combination therapy for treatment of human neurodegenerative diseases

The present disclosure provides a combination therapy to treat neurodegenerative diseases. In one embodiment, alzheimer's disease is treated with an orally administered mitochondria stimulant, neuro protective antioxidant that crosses the blood brain barrier and is supplemented with a drug that promotes hippocampal neurogenesis.

Methods for increasing blood plasma 2'-deoxyuridine (durd) and thymidylate synthase inhibition

The present invention provides methods for increasing plasma durd levels comprising the administration of 6r-mthf. The methods of increasing plasma durd increase durd levels compared to equimolar concentrations of lv.

Treatment of adipocytes

The present disclosure provides compositions comprising a lyn kinase activator and trpm8 agonist, and to methods of: reducing blood glucose levels, weight gain, or fat depot levels; treating metabolic syndrome, syndrome x, obesity, prediabetes, type ii diabetes, type i diabetes; treating hypercholesterolemia, hypertension, coronary heart disease, diabetic neuropathy, lipodystrophy, diabetic retinopathy, erectile dysfunction, kidney disease, dyslipidemia, dyslipoproteinemia, a peroxisome proliferator activated receptor-associated disorder, septicemia, a thrombotic disorder, or pancreatitis; inducing the beiging of adipocytes; and preventing pancreatic beta cell degeneration.. .

Glucose strip system

A glucose strip system which includes a container having a top surface, a bottom surface, and an inner volume, and at least one glucose strip having at least one flavoring agent. The glucose strip system includes the container and the at least one glucose strip.

System, an apparatus, and a treating a sexual dysfunctional female patient

There is disclosed an apparatus for treating a sexual dysfunctional female patient, comprising a stimulation device adapted to stimulate an erectile blood passageway to increase the amount of blood in the female erectile tissue and thereby obtaining engorgement with blood of the female erectile tissue by affecting said erectile blood flow passageway. Moreover there is disclosed a system and an operation method for treating a sexual dysfunctional female patient..

Air assisted lateral patient transfer device

An air assisted lateral patient transport system that uses a semi-permeable fabric with a uniform air permeable surface on the bottom layer of the plenum. The semi-permeable fabric provides lift to assist moving patients, and allows cleaning solutions to enter the device for cleaning.

Cold slurry containment

The present invention provides methods and devices for controlling a cold slurry that is delivered to a target tissue and for limiting heat transferring from surrounding tissue to the target tissue. In particular, a balloon structure is deployed at or near a point of delivery to act as a physical and/or thermal barrier.

Vascular valve prosthesis

A valve prosthetic implant for treating a vein or other blood vessel includes a tubular, expandable anchoring frame extending from a proximal end to a distal end of the implant, a valve seat formed at or near the middle of the anchoring frame, an expandable ball disposed within the lumen of the anchoring frame, and a ball retention tether attached to the expandable ball and to the valve seat and/or the anchoring frame. The anchoring frame may include a cylindrical proximal portion at the proximal end, a cylindrical distal portion at the distal end, an inwardly angled inlet portion between the cylindrical proximal portion and a middle of the anchoring frame, and an inwardly angled outlet portion between the cylindrical distal portion and the middle of the anchoring frame..

Systems, devices, and methods for organ retroperfusion along with regional mild hypothermia

Systems, devices, and methods for organ retroperfusion along with regional mild hypothermia. One such system includes a hypothermia system including a hypothermia system outlet and a hypothermia system inlet; and a connector comprising a coolant inlet, a coolant outlet, a coolant reservoir, and a blood lumen, whereby the coolant inlet is configured to couple to the hypothermia system outlet and whereby the coolant outlet is configured to couple to the hypothermia system inlet; whereby a cooling product, when the hypothermia system is connected to the connector, can flow from the hypothermia system, through the hypothermia system outlet, into the coolant inlet, through the coolant reservoir, into the coolant outlet, and into the hypothermia system inlet, so that the cooling product can cool blood flowing through the blood lumen..

System and enhanced data analysis with specialized video enabled software tools for medical environments

Medical software tools platforms utilize a surgical display to provide access to specific medical software tools, such as medically-oriented applications or widgets, that can assist surgeons or surgical team in performing various procedures. In particular, an endoscopic camera may register the momentary rise in the optical signature reflected from a tissue surface and in turn transmit it to a medical image processing system which can also receive patient heart rate data and display relevant anomalies.

Means and method to stop bleeding from the nose

A device for stopping bleeding from inside a nostril of a human nose. The device being formed from a sponge-like material that has an upper portion having a size and shape adapted for insertion into the nostril of a human nose and the upper portion also being formed integral with a handle, wherein an outer surface of the upper portion being coated with a material that causes blood to clot..

Method for the early detection of acute kidney injury in critical patients, using fibroblast growth factor 23, klotho and erythropoietin as biomarkers

The invention is an ex vivo method for early detection of acute kidney injury in critical patients, which includes the measurements of fibroblast growth factor 23 (fgf23), klotho (kl) and erythropoietin (epo) as biomarkers. These measurements are obtained from a venous blood sample or urine, and allow the determination of the following indicators: 1=([fgf23]p×[epo]p); 2=([fgf23]p/[klotho]p); 3=([epo]p)/[klotho]p); 4=([fgf23]p×[epo]p)/[klotho]p); where [x]p is defined as the plasma level of a specific molecule (x) which includes fibroblast growth factor 23 (fgf23), klotho (kl) or erythropoietin (epo).

Blood sample optimization system and blood contaminant sequestration device and method

Blood sample optimization systems and methods are described that reduce or eliminate contaminates in collected blood samples, which in turn reduces or eliminates false positive readings in blood cultures or other testing of collected blood samples. A blood sample optimization system can include a blood sequestration device located between a patient needle and a sample needle.

System and monitoring glucose level

A system for monitoring glucose blood level of a user is disclosed. The system comprising an illumination unit configured for providing coherent optical illumination on a selected inspection region on the user body, a collection unit configured for collecting light returning from the inspection region and generating a plurality of image data pieces associated with speckle patterns in the collected light, and a control unit comprising a processing utility and storage utility comprising pre-stored calibration data, the processing utility is configured for receiving input data on a plurality of image data pieces from the collection unit and for processing said input data for determining correlation functions between different image data pieces and using said correlation functions and said pre-stored calibration data for determining data on glucose blood level of the user..

Methods and measuring blood oxygenation of tissue

An apparatus and method of measuring oxygenation of tissue in a non-invasive manner are provided. The apparatus comprises a light source configured to emit a light pattern to be projected onto the tissue, in which the light pattern comprises superimposed patterns having different patterns.

Monitor for blood pressure and other arterial properties

A method and apparatus for monitoring arterial properties, including systolic and diastolic pressure levels, of a subject is provided, in which a hardware processor receives and analyzes ballistocardiogram (bcg) data of the subject. A non-transient computer readable medium, accessible by the hardware processor, contains instructions that, when executed by the hardware processor, identify features of the bcg waveform and determine the arterial properties therefrom.

Blood pressure measurement device wearable by a patient

Disclosed is a blood pressure measurement device that utilizing volume clamping and that is wearable by a patient. The blood pressure measurement device may comprise: a finger cuff attachable to the patient's finger including a light emitting diode (led)-photodiode (pd) pair to measure a pleth signal and a bladder surrounding the finger and a blood pressure measurement controller coupled to the bladder through a finger cuff connector to provide pneumatic pressure to the bladder.

System and blood pressure measurement

A system for use in monitoring blood circulation data of a user is disclosed. The system comprising a monitoring unit comprising at least one light source unit configured for providing and directing coherent illumination onto at least one selected inspection region on the user's body, and a collection unit configured for collecting light returning for at least a portion of the inspection region and generating a plurality of image data pieces associated with secondary speckle patterns in the collected light returning from said regions; and a control unit configured and operable for receiving said plurality of image data pieces, determining correlation functions between speckle patterns in consecutive image data pieces, processing said correlation functions for determining data indicative of at least two heart rate data sequence indicative of heart rate of the user, and determining data indicative of circulation pressure of the user in accordance with said data indicative of heart rate of the user measured at said first and second monitoring regions..

Handheld blood-flow imaging device

The present invention relates to devices and methods of use thereof for real time blood flow measurements of skin. In one embodiment, the device is a compact laser speckle imaging, or lsi, system that is integrated with a dermatoscope.

Useful information presentation device

A useful information presentation device includes a facial skin temperature acquisition unit and/or a blood circulation volume acquisition unit, a brain activity estimation unit, and a useful information presentation unit. The facial skin temperature acquisition unit acquires facial skin temperature data in time-series.

Early prediction of hypertensive retinopathy

An embodiment of the invention receives by an interface a retinal image from a patient, and identifies by a feature extraction device vessel fragments in the retinal image. The vessel fragments include at least a portion of a major vessel and at least a portion of a branch connected to a major vessel.

Method for measuring tumor burden in patient derived xenograft (pdx) mice

Kits and methods providing measurement of tumor burden in a patient derived xenograft (pdx) mouse are described. Exemplary embodiments contemplate taking a sample, typically a blood sample, from a pdx mouse and using a real-time polymerase chain reaction (pcr) system to quantitate both human patient circulating tumor dna (ctdna) and mouse dna.

Valve clip prediction

Embodiments relate to a method and system for calculating an optimal position for a valve clip to be placed and/or an optimal type of valve clip to be used for placement in a patient, based upon a simulation of the blood flow for the valve. Parameters that influence the simulation of blood flow for the mitral valve are used to conduct the simulation, the results of which are compared against certain predefined metrics.

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Diabetes management systems, methods and user reminders, pattern recognition, and interfaces

Systems, methods, and apparatus for diabetes management include a portable diabetes management system (dms) device. The dms device includes a processor, a data storage device, a touchscreen display, and wireless communications facilities.

Fractional flow reserve determination

The present invention relates to a device (1) for fractional flow reserve determination, the device (1) comprising: a model source (10) configured to provide a first three-dimensional model (3dm1) of a portion of an imaged vascular vessel tree (vvt) surrounding a stenosed vessel segment (svs) and configured to provide a second three-dimensional model (3dm2) of a pressure wire insertable into the vascular vessel tree (vvt); and a processor (20) configured to calculate a first blood flow (q1) through the stenosed vessel segment (svs) with the pressure wire (pw) inserted into the vascular vessel tree (vvt) based on the first and the second three-dimensional model and to calculate a second blood flow (q2) through the stenosed vessel segment (svs) without the pressure wire (pw) inserted into the vascular vessel tree (vvt) based on the first three-dimensional model (3dm1) and to determine a first fractional flow reserve value (ffr1) to be measured with the pressure wire (pw) inserted into the vascular vessel tree (vvt) based on the first blood flow (q1) and to determine a second fractional flow reserve value (ffr2) to be measured without the pressure wire (pw) inserted into the vascular vessel tree (vvt) based on the second blood flow (q1).. .

Methods of cross correlation of biofield scans to enome database, genome database, blood test, and phenotype data

Systems and methods are provided for identifying characteristics of a subject using a biofield scan obtained from the subject. An embodiment can include a method for cross-correlating biofield scans to an enome database, and/or a genome database.

Method for optimizing the predetermination of the time profile of a contrast agent concentration in diagnostic imaging using a magnetic resonance system

A method of predetermining the time profile of a contrast agent concentration at a vessel position is provided in the context of contrast agent-enhanced mri of a region of interest only during the initial flooding-in phase of the contrast agent into the vessel situated in the region of interest. The method includes establishing a broadening of a contrast agent bolus profile according to the equation Δw=w2−w1 wherein w1 is a first width of the contrast agent bolus profile at a first vessel position and w2 is a second width of a contrast agent concentration profile at a second vessel position within the region of interest.

System and hand-held probe for non-invasive real time magnetic resonance analysis of body tissue

A system for non-invasive analysis of tissue includes a non-ferromagnetic handheld probe (15) distinguishing between nerves, muscles and blood vessels. A magnetic field source in the probe generates a uniform, time-invariant magnetic field within a volume of tissue and contains an inductive coil (19) that receives rf excitation signals in a specific frequency range related to the field strength thereby generating excitation signals perpendicular to a direction of the magnetic field and magnetizing a slice of the living tissue having depth and thickness predetermined by the field strength whereby only living tissue in each slice responds to nuclear spin echo signals.

Method for diagnosing aps using determination of anti-par1 antibodies

The application relates to a method for diagnosis of an antiphospholipid syndrome (aps) in a subject, wherein presence or absence of an anti-protease-activated receptor 1 (par1) antibody is detected in a sample from the subject diagnosed, and wherein the presence of an anti-par1 antibody is indicative of the disease. Furthermore, it relates to the use of par1 for the diagnosis of aps, as well as to a method of removing anti-par1 antibodies from isolated blood of a subject upon detection of said anti-par1 antibodies in a sample of said patient..

Mobile blood alcohol content and impairment sensing device

In a mobile sensing device, a method of detecting blood alcohol content includes receiving time-series gait data from at least one sensor of the mobile sensing device as a user walks and detecting a set of attributes associated with the time-series gait data, each attribute of the set of attributes related to the user's gait. The method includes comparing the set of attributes with a machine learning classification model learned from a training data set of attributes to determine at least one of a blood alcohol content range of the user and an impairment level of the user and outputting a notification associated with the at least one of the blood alcohol content range of the user and the impairment level of the user..

Device and methods of using device for detection of hyperammonemia

The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflurinated membrane that comprises an ionomer in contact with an alkali buffer in a vessel configured to receive a sample, such as whole blood.

Monitoring treatment or progression of myeloma

The present invention relates to methods and kits for diagnosing myeloma, monitoring disease progression or treatment efficacy in an individual having a myeloma. In one aspect, the invention relates to a method for monitoring the response of an individual to treatment for multiple myeloma, the method comprising providing cell-free nucleic acids derived from a sample of peripheral blood from an individual that has undergone treatment for multiple myeloma; assessing the cell-free nucleic acids for a mutation in any one or more nucleotide sequences from a kras, nras, braf and/or tp53 gene; wherein an absence of, or reduction in the number of, mutations in a nucleotide sequence from a kras, nras, braf and/or tp53 gene indicates a response of the individual to treatment for multiple myeloma..

Compositions and methods for measuring blood glucose levels

In some embodiments, the present invention provides a protein comprising amino acids in the following sequence l(x)n=14x3(x)n=1x1(x)n=1e(x)n=4p(x)n=1nr(x)n=3s(x)n=4d(x)n=2g(x)n=7y(x)n=4y (x)n=32-34x2, wherein each x independently represents any naturally occurring amino acid residue and n indicates the number of amino acid residues represented by the respective parenthetical at that position, wherein: a) x1 is selected from the group consisting of s, c, t, m, v, y, n, p, l, g, q, a, i, d, w, h, or e, wherein if x1 is l, h or v, then x3 is d; and/or b) x2 is selected from the group consisting of h, l, s or v. In some embodiments, the present invention also provides a protein comprising amino acids in the sequence set forth by seq id no: 38 or seq id no: 39, except that: the amino acid at position 406 is an amino acid other than f; and/or the amino acid at position 474 is an amino acid other than n..

Cell culture model of vascular calcification

The present invention relates to a cell culture model of vascular calcification, comprising a first type of cultured vascular smooth muscle cells and a second type of cultured vascular smooth muscle cells, wherein the first type and the second type of vascular smooth muscle cells originate from blood vessels having a different diameter, e.g., from the human aorta and from a human coronary artery, respectively. This model allows to generate and analyze vascular calcification processes, including early calcification processes, in an advantageously simple and cost-effective way and with high sensitivity.

Medical macromolecular microsphere adsorbent for a blood perfusion apparatus and a preparation method thereof

A medical macromolecular microsphere adsorbent for a blood perfusion apparatus and a preparation method thereof are provided. The polystyrene-divinylbenzene microspheres are graded by different pore sizes and specific surface areas, medically purified, and grafted by a bioactivity-controlled grafting technology.

Filter device, filtration of fluids

A filter device (10) for filtration of fluids, in particular for the dialysis of blood. The filter device (10) comprises a housing (12) having a first end (14) and a second end (16) and defining a fluid chamber (18) extending between the first end (14) and the second end (16).

Systems, methods and devices for preventing tissue damage

A sensor interface device (e.g., orthotic device or immobilization device) is disclosed. More specifically, described is an individualized sensor device and system to prevent tissue damage resulting from, for example, pressure, torsion, temperature, shear, altered blood flow, reduced oxygen tension, ph levels, tissue conductivity, tissue viscoelasticity, infection and sweat chloride levels.

Systems and methods to prevent catheter occlusion

A system to detect occlusion of an intravenous catheter may include a housing, which may include a distal end configured to couple to a proximal end of a catheter adapter and an inner lumen forming a fluid pathway. The system may also include one or more transmitters, which may be disposed within the housing.

Heart vent catheter and use

A heart vent catheter includes an elongate, flexible tube that defines a first passageway. The catheter has a distal end, a central portion, and a proximal end.

Arteriovenous graft for minimizing arterial steal and graft thrombosis

An arteriovenous dialysis access graft is configured to be implanted in a body of a subject. The arteriovenous dialysis graft comprises a flexible conduit defining a longitudinal flow passageway.

Dialysis system and method including a flow path insulator

A renal failure therapy system (10) includes: a dialyzer (102); a blood circuit (100) including a blood pump (120) in fluid communication with the dialyzer (102); a dialysis circuit (30) in fluid communication with the dialyzer (102); and at least one flow path insulator (150, 155) located in the dialysis circuit (30) or the blood circuit (100), the flow path insulator (150, 155) including a structure that separates liquid flowing within the flow path insulator (150, 155) into a plurality (e.g., two or more) of separated liquid segments (160) that create electrical isolation within the flow path insulator (150, 155).. .

Device for therapeutic plasma exchange

A device for therapeutic plasma exchange includes an extracorporeal circuit, which includes a blood supply line, a separating unit, a line for infusion of formed elements, a line for infusion of replacement fluid, a blood plasma line, an anticoagulant line and at least one independent line for therapeutic drugs. The independent line can include a storage for the therapeutic drug, a conveyer of therapeutic drug, a propelling device and a controller configured to control flow of the therapeutic drug..

Pressure sensing ventricular assist devices and methods of use

The invention generally relates to heart pump systems. In some embodiments, a pressure sensor is provided with a heart pump, either at the inflow or the outflow of the blood pump.

Adjusting pump protocol based on irregular heart rhythm

The present invention generally relates to heart treatment systems. In some aspects, methods and systems are provided for facilitating communication between implanted devices.

Communication methods and architecture for heart treatment systems

The present invention generally relates to heart treatment systems. In some aspects, methods and systems are provided for facilitating communication between implanted devices.

Thermistor imbedded therapeutic catheter

A system and method for determining native cardiac output of a heart while maintaining operation of an intracardiac blood pump includes determining a current drawn by the pump motor, a blood pressure within the ascending aorta, and a change in the blood temperature based on a thermodilution technique. An intracardiac blood pump positioned in the aorta includes at least one sensor for determining a motor current and blood pressure and a thermistor for determining the change in blood temperature after a precise fluid bolus has been introduced into the vasculature.

Compositions derived from placenta and methods of producing the same

Compositions comprising unseparated amnion/chorion derived from the placenta and methods of preparing and using those compositions are provided. Washing or preservation of placental tissue according to the methods of the disclosure may allow for one or more benefits such as more efficient removal of blood remnants, retention of wound healing and tissue regeneration components, better handling characteristics, increased absorption potential, or improved healing capacity.

Treatment of blood

Activation of senescent stem cells in humans to promote wound healing and other therapies, and to promote general enhancement of health by application of non-thermal atmospheric pressure plasma (ntapp) to tissues and body fluids such as blood. In particular, the targets of the ntapp are stem cells.

Nanoparticle based tumor endothelial targeting vaccine

Disclosed are methods, compositions of matter, and therapeutic protocols for treatment of cancer by selectively inducing immune responses against blood vessels feeding neoplastic tissue. In one embodiment, placental endothelial cells are stimulated with phorbol myristate acetate (pma) to induce release of nanoparticles that possess ability to: a) be taken up by antigen presenting; b) presented through direct and indirect presentation to cd4 and cd8 t cells, respectively; and c) utilized to stimulate cytoxic t cellular and humoral responses to selectively inhibit angiogenesis of tumors..

Diagnosis and treatment of parkinson's disease based on identification and amelioration of liver dysfunction

Disclosed are methods for diagnosing parkinson's disease, or identifying a risk of developing parkinson's disease, comprising measuring the amount of a biomolecule in a blood sample, liver sample, or hepatocyte. Also disclosed are methods for preventing or treating parkinson's disease, comprising administering a therapeutically effective plurality of hepatocytes to a subject in need thereof..

In vitro production of red blood cells with sortaggable proteins

Methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express a sortaggable surface protein, which allows for surface modification in the presence of a sortase.

Proton-binding polymers for oral administration

Pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing such compositions. The pharmaceutical compositions contain crosslinked amine polymers and may be used, for example, to treat diseases or other metabolic conditions in which removal of protons and/or chloride ions from the gastrointestinal tract would provide physiological benefits such as normalizing serum bicarbonate concentrations and the blood ph in an animal, including a human..

Treatments and diagnostics for cancers

Treatments and diagnostics for treatment efficacy against solid and liquid cancers are described. The treatments utilize a combination therapy of galeterone and a proteasome inhibitor.

Use of inhibitors of bruton's tyrosine kinase (btk)

Disclosed herein are methods for treating a cancer comprising: a. Administering a btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b.

Short acting phenylalkylamine calcium channel blockers and uses thereof

The present invention relates to the use of a pharmaceutically effective amount of an short-acting calcium channel blocking compound to treat ischemic heart conditions, cardiac arrhythmias, hypertensive crisis in an emergency room setting, hypertension before, during, or after surgery, no-reflow phenomenon following reperfusion, and diseases associated with decreased skeletal muscle blood flow. The invention also relates to pharmaceutical compositions formulated for use in such methods and to kits for such methods..

Methods of treating injuries or conditions related to cns edema

The present technology is related to reducing or treating neurological swelling and related conditions with sur1-trpm4 channel inhibitors. In some embodiments, the methods include: reducing late neurological deterioration or preventing death, reducing cerebral midline shift, reducing the degree of disability in a subject, counteracting blood glucose levels in a subject receiving a sur1-trpm4 channel inhibitor, preventing brain swelling, monitoring liver enzyme activity along with treating injury or conditions related to cns edema, or monitoring cardiac activity along with treating injury or conditions related to cns edema..

Methods and luminal stenting

Described herein are flexible implantable occluding devices that can, for example, navigate the tortuous vessels of the neurovasculature. The occluding devices can also conform to the shape of the tortuous vessels of the vasculature.

Blood flow diversion device

A blood flow diversion device to treat an aneurysm at a bifurcation artery, the blood flow diversion device having a plurality of legs that anchors the blood flow diversion device onto a parent artery of the bifurcation artery, and a plurality of branches that extends from the plurality of legs. The plurality of branches includes a plurality of upstream branches positioned above the plurality of legs to lie on a upstream portion of an aneurysm entrance of the aneurysm and divert the blood flow towards children arteries of the bifurcation artery, and a plurality of downstream branches positioned above the plurality of upstream branches to extend within an internal volume of the aneurysm and promote thrombosis formation in the internal volume..

Vascular filter device

A vascular filter device comprises a support; and a filter comprising one or more filter elements configured to capture thrombus passing through a blood vessel. A holder holds the filter in a closed filtering state and releases to convert the filter to an open state after a period of time.

Monitoring nerve activity

Systems and methods provide interface to a patient's autonomic nerves via an interior lumen wall of a blood vessel. Systems can include a probe having at least one electrode for receiving electrical signals from the interior of the lumen wall.

Increased axial load carrying sheathed irrigating balloon catheter

A sheathed tubular semi-rigid balloon catheter for performing probing, irrigation, dilation, suction and potential intubation of the nasolacrimal system or paranasal sinus system to treat for stenosis or obstruction. The catheter includes a sheathed tubular probe portion through which a tracer fluid can be injected and through which suctioning of blood or other material can be conducted.

Vascular remodeling device

A vascular remodeling device is provided. The device has an anchor portion, sized for deployment in a blood vessel, that is radially expandable from a collapsed state to an expanded state.

Treatment method

A treatment method is disclosed, which is capable of causing a medical elongated body to indwell the inside of a palmar artery of a patient, while suppressing kink, poor torque transmission ability, and poor operability of the medical elongated body. The treatment method includes causing a sheath tube of an introducer introduced into a blood vessel via a puncture site formed on an ulnar artery side of a palmar artery of the patient, to indwell the puncture site..

Portable ultrasound device

Systems and methods for stroke detection in accordance with embodiments of the invention are illustrated. One embodiment includes a system for detecting strokes, including a processor, a first ultrasound transmitter located on a patient's head in communication with the processor, a first ultrasound receiver located on the patient's head in communication with the processor, a memory in communication with the processor, including a stroke diagnostics application, where the stroke diagnostics application directs the processor to transmit a first ultrasound signal from the first ultrasound transmitter across a patient's brain, the brain comprising a first and second hemisphere, receive the first ultrasound signal using the first ultrasound receiver, where the ultrasound signal is affected during transit by harmonics generated by microbubbles in the blood of the patient stimulated by the first ultrasound signal, and detect that a stroke has occurred based on the harmonic effects on the first received ultrasound signal..

Determination and presentation of flow transit curves

A system and method includes reception of an indication of a region of interest of a plurality of image frames, determination of a first set of pixel locations of the region of interest which depict blood vessels, determination of a second set of pixel locations of the region of interest which depict non-vessel tissue, determination, for each of the plurality of the image frames, of a first contrast medium concentration corresponding to the first set of pixel locations, determination, for each of the plurality of the image frames, of a second contrast medium concentration corresponding to the second set of pixel locations, and display of a visualization depicting a first contrast medium concentration and a second medium concentration with respect to the respective time of each of the plurality of the image frames.. .

Medical image processing apparatus, medical image processing method, and x-ray diagnostic apparatus

A medical image processing apparatus comprises processing circuitry configured to select a reference image from blood vessel images based on contrast images acquired in time series and conduct a transformation process on other blood vessel images such that blood vessel shapes in the other blood vessel images match a blood vessel shape in the reference image, generate a color image where a color that corresponds to a temporal change in a pixel value is assigned to each pixel based on the blood vessel images after the transformation process, and display the color image on a display.. .

X-ray diagnostic apparatus, image processing apparatus, and image processing method

An x-ray-diagnostic apparatus generates time-series first vessel images corresponding to a first direction, and generates second vessel image corresponding to a second direction. The apparatus generates third vessel images corresponding to the second direction, by transforming more than one piece out of the first vessel images based on a blood vessel shape in one of the first vessel images and a blood vessel shape in at least one of the second vessel image, the third vessel image corresponding to respective time phases of the first vessel images.

Ambulatory blood pressure and vital sign monitoring apparatus, system and method

Representative methods, apparatus and systems are disclosed for determining one or more physiological parameters, such as for ambulatory blood pressure and other vital sign monitoring. A representative system comprises first and second wearable apparatuses to be worn on the user's left and right sides, and any of several types of central vital signs monitors.

Wearable blood pressure measurement systems

Systems and methods for receiving galvanic skin response data from a galvanic skin response sensor that includes multiple electrodes fastened to a hand of a human; monitoring the galvanic skin response data to determine a time for initiating a blood pressure (bp) measurement using a blood pressure measurement cuff worn by the human (e.g., in a continuous or on-demand bp measurement mode); at the determined time, initiating the blood pressure measurement using the blood pressure measurement cuff; receiving blood pressure data for the human that results from the blood pressure measurement; and storing a blood pressure value that is based on the blood pressure data.. .

Liquid sample measurement device with removable lancet or biosensor

This liquid sample measurement device is provided with: a lancet mounting part to and from which a lancet device having a skin contact section for puncturing skin can be attached and detached; a sensor mounting part to which a biosensor, which is spotted with blood that comes out from the punctured skin, can be attached; and a measurement part that uses the biosensor attached to the sensor mounting part to measure the amounts of substances in the blood. The liquid sample measurement device includes a feature that makes it necessary to replace a lancet device that has been attached to the lance mounting part and has punctured skin, each time a lancet device is used to puncture skin..

Dickerson medical meter

The dickerson medical meter assist diabetic people which manage their insulin levels and tells them the amount of insulin intake that they need at the time. The device uses a fingerprint sensor to read insulin levels and provides instructions if steps are needed to control blood sugar immediately.

Methods and systems for correcting blood analyte measurements

A system, transceiver, and method for calculating and correcting levels (e.g., analyte levels) in a first medium (e.g., blood) using measurements from a second medium (e.g., interstitial fluid). In some embodiments, a transceiver may calculate an initial second medium level.

Analyte sensor user interface apparatus and methods

User interface (ui) apparatus and associated logic and methods for use with a blood analyte sensor. In one embodiment, the blood analyte sensor comprises an implantable blood glucose sensor, and the ui and associated logic are configured to receive and store user-specified parameters for operation of the blood analyte sensor and/or associated receiver.

System and cuffless blood pressure estimation

Disclosed is a system for estimating arterial blood pressure. The system includes a heartbeat detection module configured to receive an electrocardiogram signal, and detect one or more qrs complexes of the electrocardiogram signal.

Methods and physiological measurement using color band photoplethysmographic sensor

In illustrative implementations of this invention, a photoplethysmographic device measures variations of light that is reflected from, or transmitted through, human skin. In some implementations, the device includes a camera that takes the measurements remotely.

Sensor

A sensor includes a probe that acquires a blood light absorber concentration in a subject and a cuff that acquires a non-invasive blood pressure of the subject. In the sensor, the probe is configured to be attached to a first portion of a digit of the subject, and the cuff is configured to be attached to a second portion of the digit, the second portion being located on a periphery side with respect to the first portion..

Wrist-worn blood pressure monitor

The present invention provides a wrist-worn blood pressure monitor that is worn around a wrist. The wrist-worn blood pressure monitor according to the present invention includes a wrist cuff including a wrist strap so as to be worn around a wrist, a sensor provided at the wrist cuff in order to measure blood pressure, and a tightener provided at the wrist cuff in order to selectively tighten the wrist cuff so that the wrist cuff compresses the wrist.

Blood pressure measurement device and calibration method thereof

The present application discloses a blood pressure measurement device, includes: a blood pressure measurement body configured to measure blood pressure based on photoplethysmogram (ppg), and a calibrator configured to measure blood pressure values based on korotkoff sounds. The calibrator is further configured to provide initial calibration parameters to the blood pressure measurement body, and the blood pressure measurement body is further configured to collect an ecg signal and a ppg signal, calibrate a ppg parameter-blood pressure equation according to the initial calibration parameters, and calculate a blood pressure value according to the ppg parameter-blood pressure equation..

Device and non-invasive measurement of subdiaphragmatic aortic flow in a small laboratory mammal

A device non-invasively measures aortic flow in the subdiaphragmatic region in a small laboratory mammal. The device includes a device for plethysmography of the thorax by inductance measurement, having two electrically conducting, extendible coils rigidly attached to an elastic garment that is adjustable to the torso of the mammal, a device for acquiring the signal from variation in the cross-section of each coil, and a processor configured to calculate the instantaneous subdiaphragmatic aortic flow of the mammal from the signals from the variation in cross-section of each coil and from a functional model of the cardiorespiratory system.

Method and device for optimizing the measurement accuracy in vivo when measuring invasive blood pressure using a fluid-filled catheter-manometer system

Method and device for optimizing the measurement accuracy in vivo when measuring invasive blood pressure using a fluid-filled catheter-manometer system including a medical signal processing device; a catheter; a pressure line connected to the catheter; a pressure transducer-flush system unit connected to the pressure line and to a pressurised storage bag, and having an integrated pressure transducer and an integrated flush system, the pressure transducer having a membrane to convert a pressure signal into an electric signal that is transmitted to the medical signal processing device, the flush system ensuring that a continuous flush from the storage bag to the catheter is maintained, the flush system having a manually operable element configured for temporarily, briefly opening and closing the flush system. The following values are calculated: a natural frequency, damping coefficient, a dynamic response diagram using the calculated natural frequency and damping coefficient, and an inverted dynamic response diagram used as a filter to process a signal measured by the pressure transducer; and afterwards, an invasive blood pressure signal and invasive blood pressure values are calculated from the processed signal..

Mri system, mri apparatus, and mri method

In one embodiment, an mri apparatus is configured to be connected with a pressure device that externally pressures a blood vessel of an object, and includes a scanner configured to perform imaging on the object and processing circuitry. The processing circuitry controls the pressure device in such a manner that ischemia and reperfusion are caused with respect to the object, determines a start timing of the imaging on the basis of a state of pressurization caused by the pressure device, causes the scanner to perform the imaging on the object in accordance with the start timing, and generates an image by using data acquired in the imaging..

Blood flow measurement apparatus

A blood flow measurement apparatus of an embodiment includes an image acquisition unit, an image region specification unit, a measurement location setting unit, a scanner, and a blood flow information generation unit. The image acquisition unit acquires an image of a living body.

Protoporphyrin ix (ppix) imaging

A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remain in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject.

Endorecherche, Inc.

. .

Biological imaging device and biological imaging method

A fingertip guide of a biological imaging device guides a fingertip, and a light emitting device of the biological imaging device emits light to a first part. An imaging device of the biological imaging device captures a fingerprint of the first part and a blood vessel of a second part by a reflected light and a radiated light.
Nec Corporation

Biometric authentication of individuals utilizing characteristics of bone and blood vessel structures

Biometric authentication of a subject utilizing bone and/or blood vessel (vein or artery) structures is provided. A vertice profile is generated from a non-invasive, multi-dimensional image scan of a subject or a portion thereof.
Youaretheid, Llc

Systems and methods for assessment of tissue function based on vascular disease

Systems and methods are disclosed for assessing tissue function based on vascular disease. One method includes receiving a patient-specific anatomic model generated from patient-specific imaging of at least a portion of a patient's tissue; receiving a patient-specific vascular model generated from patient-specific imaging of at least a portion of a patient's vasculature; receiving an estimate of blood supplied to a portion of the patient-specific anatomic model; and determining a characteristic of the function of the patient's tissue using the estimate of blood supplied to the portion of the patient-specific anatomic model..
Heartflow, Inc.

Predictive test for patient benefit from antibody drug blocking ligand activation of the t-cell programmed cell death 1 (pd-1) checkpoint protein and classifier development methods

A method is disclosed of predicting cancer patient response to immune checkpoint inhibitors, e.g., an antibody drug blocking ligand activation of programmed cell death 1 (pd-1) or ctla4. The method includes obtaining mass spectrometry data from a blood-based sample of the patient, obtaining integrated intensity values in the mass spectrometry data of a multitude of pre-determined mass-spectral features; and operating on the mass spectral data with a programmed computer implementing a classifier.
Biodesix, Inc.

Detection of blood vessels

A system for the detection of blood vessels includes an image sensor coupled to generate video data including a sequence of images of the blood vessels, and a heart rate monitor to measure a heart rate of a patient and to generate heart rate data. A controller is coupled to the image sensor to receive the video data, and coupled to the heart rate monitor to receive the heart rate data.
Verily Life Sciences Llc

Incorporation of statistical strength into voxels in an fmri image

Technology is described for incorporating statistical strength from neighboring voxels in an fmri image. The method can include the operation of capturing an fmri image of a human organ and the fmri image includes statistical values for voxels in order to detect changes associated with blood flow representing organ activity.
Novarad Corporation

Controller and user interface device, systems, and methods

A data collection system controller that includes a housing such as a cover. The housing includes a user facing section and a support facing section defining a hole.
Lightlab Imaging, Inc.

Cine phase contrast simultaneous multi-slice and multi-slab imaging of blood flow and cerebrospinal fluid motion

An mri method and an mri system that simultaneously detect blood and/or csf velocity or flow in plural slices or slabs preferably as not spatially adjacent. Two or more sets of interleaved slices or slabs can be assembled to cover the desired volume and derive higher quality mri signals and images without a need for a contrast agent, even where the volume is too large for effective flow imaging with known techniques without contrast agent..

Synthetic blood vessels and uses thereof

The present invention provides a synthetic blood vessel and use thereof in drug screening, drug delivery and prognoses of cerebrovascular dysfunction.. .
The University Of British Columbia

Method for diagnosing, preventing and treating cancer brain metastasis, and drug delivery system for enabling passage through blood-brain barrier

A purpose of the present invention is to provide a diagnosis and risk evaluation method for cancer brain metastasis and a treatment and prevention method therefor by clarifying the mechanism of blood-brain barrier (bbb) disruption in brain metastasis. Another purpose of the present invention is to provide a drug delivery system to the brain.
Theoria Science Inc.

Nucleic acid sample preparation

The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples..
Biological Dynamics, Inc.

Cord blood therapy to treat chronic disease caused by l-form bacteria

The present disclosure describes screening cord blood for antibacterial activity against l-form bacteria, methods of treating a patient having an l-form bacterial infection using a cord blood agent, and methods of killing or inhibiting l-form bacteria in an in vitro or ex vivo setting. L-form bacteria underlying an l-form bacterial infection are isolated from a subject having an infection and are altered to a culturable morphology.
Soft Cell Biological Research, Llc

Modified blood clotting factors and methods of use

The invention provides compositions including modified blood clotting factors that have a non-native proteolytic cleavage site engineered into them allowing intracellular cleavage and secretion of an active form. The compositions are useful in the methods for treating a bleeding or clotting disorder..
The Children's Hospital Of Philadelphia

Adhd marker, application thereof and kit

The present invention provides a marker for adhd and applications thereof. The marker is ghrelin, and the marker can screen for potential adhd patients by detecting the marker in peripheral blood or cerebrospinal fluid.
Institute Of Hydrobiology, Chinese Academy Of Sciences

Small molecule affinity membrane purification systems and uses thereof

Disclosed are purification systems and methods for providing purified preparations of antibodies from a fluid, particularly a biological fluid comprising or suspected to contain antibody (e.g., blood, serum, plasma, ascites fluid). Reusable and stable synthetic purification columns comprising membranes of a suitable separation matrix material, such as a nylon membrane or regenerated cellulose membrane, having conjugated thereto a small molecule capture ligand, such as a short peptide or protein capable of acting as a ligand for a particular antibody of interest, such as a peptide having a sequence with binding affinity for a nucleotide binding site (nbs) of a selected antibody of interest, are also provided.
University Of Notre Dame

Treatment of multiple sclerosis and psoriasis using prodrugs of methyl hydrogen fumarate

Improved methods of treating multiple sclerosis and/or psoriasis using prodrugs of methyl hydrogen fumarate are disclosed. The methods comprise administering certain prodrugs of methyl hydrogen fumarate.
Xenoport, Inc.

Hydrophilic fentanyl derivatives

Various fentanyl derivatives are described. The derivatives exhibit high binding affinity to opioid receptors, but also have decreased blood brain permeability as compared to standard fentanyl.
Allegheny-singer Research Institute

Disposable cartridge with hinged cap

A disposable cartridge and method for measuring one or more properties of a blood sample are provided. The disposable cartridge can receive a sample when it is in an unsealed configuration.
Invidx Corp.

Micro-coil wristband

An erythrocyte de-aggregation system includes a band, including a strap and housing securing an iron-cored, micro-coil to an appendage, such as a wrist, of a subject to apply a pemf into a target vessel in the vascular system of the subject. Typically, all of the blood circulates about the body within a matter of a few minutes, some within seconds, thus treating the entire bloodstream over time.
Pulse, Llc

Bi-directional cannula

A bi-directional cannula for perfusing blood in two directions. The cannula has a distal opening in fluid communication with a cannula first lumen.
Edwards Lifesciences Corporation

Localized therapy delivery and local organ protection

A system for perfusing a localized site within a body includes a catheter assembly having a venous access line that is adapted to deliver perfusate to the localized site, a venous or arterial drainage line adapted to drain perfusate from the localized site, and an occlusion device adapted to prevent some or substantially all physiological blood flow between the localized site and the systemic circulation of the body during and in the course of perfusing and draining perfusate to and from the localized site. The system may include a blood circuit associated with the catheter assembly to facilitate blood conditioning for use as the perfusate, in the course of a controlled perfusion and/or drainage of untreated, treated, or inactivated treated blood to and from the localized site.
Nirva Medical, Llc

Removable pressure sensor and extracorporeal circulator provided with removable pressure sensor

A removable pressure sensor assembly senses a pressure in an elastically deformable tube conveying blood in an extracorporeal circulator. The assembly includes a main body portion 31 and a pressure measurement element 40 disposed in main body portion 31.
Terumo Kabushiki Kaisha

Blood recirculation device

The present invention relates to a blood recirculation device. More particularly, the present invention relates to a blood recirculation device capable of continuous blood suction and capable of minimizing mechanical damage to the blood during such a process.
Catholic Kwandong University Industry Foundation

Trans carotenoids, their synthesis, formulation and uses

The invention relates to trans carotenoid compounds and salts thereof as well as compositions thereof, methods for making them, and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans..
Diffusion Pharmaceuticals Llc

Use of tomato extract as antihypertensive agent and process for making water soluble sugar free tomato extract

Provided herein is technology relating to tomato extracts and particularly, but not exclusively to preparing and using tomato extracts as an anti-hypertensive agent to modulate blood pressure.. .
University Of Oslo

Compound and reducing inflammation, pain, allergy, flu and cold symptoms

The present invention relates to pharmaceutical and nutraceutical compounds and methods for reducing inflammation, blood sugar, gastric acid, symptoms of allergy, common cold and flu, as well as treating infections and pain associated with trauma, medical procedure, and diseases and disorders in subjects in need thereof. The compounds and methods proposed by this invention are related to essentially a mixture of naturally accruing and/or synthetic substances in certain ratios, administration protocols, and delivery systems that amplify their medicinal qualities and reduce side effects, making their clinical application feasible..

Red blood cell membrane-derived microparticles and their use for the treatment of lung disease

Cell-based therapies show considerable potential as an immunomodulatory strategy for a variety of lung diseases, including chronic obstructive pulmonary disease (copd), asthma, bronchiolitis, acute lung injury, lung allograft rejection (acute or chronic), pulmonary fibrosis. Described herein is the development of red blood cell membrane-derived microparticles (rbc mps), which are depleted of hemoglobin (hb) and express phosphatidylserine on their surface, for the treatment of lung disease.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education

Intramuscular administraton of autologous bone marrow for treatment

Disclosed herein are methods of ameliorating or inhibiting critical limb ischemia or a condition associated with critical limb ischemia in a subject, whereby such methods comprise identifying a subject having a peripheral vascular disease, peripheral arterial disease, critical limb ischemia or a condition associated with critical limb ischemia and providing to said subject a composition comprising: a cell population, wherein the cell population comprises bone marrow total nucleated cells and red blood cells, an anticoagulant, and autologous plasma, wherein the composition has a viscosity of 1.5 to 5.0 centipoise (cp) measured at 37° c., wherein the composition comprises a viable cell dose and, wherein said composition is administered to said subject intramuscularly through a standard terminally-ported cannula needle, or a cannula side-ported needle or catheter comprising a plurality of ports and a closed end.. .
Cesca Therapeutics, Inc.

Hemostatic compositions, devices, and methods

Compositions that include a clay such as kaolin dispersed in a liquid such as water may be useful for promoting the clotting of blood. The compositions may be in a liquid, gel, paste, foam, or another form.
Z-medica, Llc

Treatment of alzheimer's disease using compounds that reduce the activity of non-selective ca++ activated atp-sensitive cation channels regulated by sur1 receptors

Nsc antagonists are disclosed as useful in the treatment of dementia, in delaying the onset of dementia, and in the prevention of dementia. Dementia so treated may be, for example, alzheimer's disease (ad).
Biogen Chesapeake Llc

Biomedical container to collect and test blood or a blood component

Biomedical container to collect and test blood or a blood component, comprising a collection chamber for blood or a blood component; a test chamber for blood or a blood component; and a test kit in the test chamber to test the blood or the blood component contained therein. The collection chamber and the test chamber are intended to be connected so as to be unequivocally mutually associated and to be supplied with the same blood or blood component..

Subcutaneous vascular assemblies for improving blood flow and related devices and methods

Medical devices and related method for improving blood flow to regions of a patient are described herein. Some medical devices may include a first graft portion, a second graft portion, and a catheter portion disposed between the first graft portion and the second graft portion.
Merit Medical Systems, Inc.

Subcutaneous vascular assemblies for improving blood flow and related devices and methods

Medical devices and related method for improving blood flow to regions of a patient are described herein. Some medical devices may include a first graft portion, a second graft portion, and a catheter portion disposed between the first graft portion and the second graft portion.
Merit Medical Systems, Inc.

Vascular access device

An access device for placing a medical article within a body space includes a needle, a dilator, and a sheath. The dilator can be coaxially and slideably disposed about the needle, and the sheath can be coaxially and slideably disposed about the dilator.
Access Scientific, Llc

Clot retrieval system

A platform of devices for removing obstructions and other objects within a blood vessel or other interior lumen of an animal is provided. The system may be deployed in the lumen from a catheter(s) and the system includes a proximal hub, and a distal basket comprised of a plurality of cells.
Legacy Ventures Llc

High resolution intravascular ultrasound imaging systems and methods

Disclosed is a high resolution intravascular ultrasound imaging system including a catheter with a rotatable imaging assembly and an image processor. The image processor in turn features a pulser configured to energize the ultrasound transducer of the rotatable imaging assembly with a multi-frequency ultrasound waveform signal.
Intraredx, Inc.

Smart toilet with a function of human blood pressure detection

A smart toilet with a function of human blood pressure detection, the smart toilet includes a toilet base. The smart toilet further includes a body connected to the toilet base.
Zhongshan Anbo Health Technology Co., Ltd.

Blood contaminant sequestration device with one-way air valve and air-permeable blood barrier with closure mechanism

Blood sample optimization systems and methods are described that reduce or eliminate contaminates in collected blood samples, which in turn reduces or eliminates false positive readings in blood cultures or other testing of collected blood samples. A blood sample optimization system can include a blood sequestration device located between a patient needle and a sample needle.
Kurin, Inc.

Sensor

A sensor includes a probe that acquires a blood light absorber concentration in a subject and a cuff that acquires a non-invasive blood pressure of the subject. In the sensor, the probe is configured to be attached to an interdigital area between first and second digits of a hand or foot of the subject, or a palm of the hand, and the cuff is configured to be attached to one of the first digit, the second digit, a third digit of the hand or the foot, a wrist of the hand, and an ankle of the foot..
Nihon Kohden Corporation

Method and a device for non-invasive monitoring of a blood glucose level of a user

A method and a device are described for non-invasive monitoring of blood glucose level of a user. The method includes determining an electrical skin impedance between a first point and a second point of a surface of skin of user using a skin impedance sensor.
Wipro Limited

Soft gripper and blood pressure measuring cuff comprising the same

A soft gripper that surrounds and grips an outer peripheral surface of an object, the soft gripper includes an elongated first actuator and an elongated second actuator, which are deformed in response to supply of a fluid. The first actuator and the second actuator extend from bases of the first and second actuators toward opposite sides each other.
Omron Corporation

Information processing device, information processing method, and information processing program

This information processing device is provided with: a receiving unit which receives a detected value detected by means of a head-mounted device which is worn on the head of a user and detects the blood flow rate in the head; a calculating unit which extracts a first signal by passing the detected value through a first filter which extracts a signal in a first frequency band, extracts a second signal by passing the detected value through a second filter which extracts a signal in a second frequency band, which is a frequency band that is higher than the first frequency band, and extracts a third signal, which is the envelope of the second signal, from the second signal; and an output unit which outputs the first signal and the third signal in association with one another.. .
Neu Corporation

Approach for measuring capillary refill time

The capillary refill time (crt) of a patient is an important feature in the determination of cardiovascular system health quick reperfusion of the microcirculation (namely, the capillaries) is a good indication that the cardiovascular system is able to efficiently distribute blood throughout the body. Current systems use unreliable or subjective methods to test the crt.
Koninklijke Philips N.v.

Robust myocardial blood oxygen level dependent magnetic resonance imaging with improved patient comfort

The invention provides various methods for imaging a subject's cardiovascular system. The imaging method may be used to provide a diagnosis or prognosis of various cardiovascular diseases in the subject, without contrast agents or radioactive tracers, and further generating a gaussian mixture model to obtain a reference value of a normal myocardium..
Cedars-sinai Medical Center

Endoscope system, processor device, and operating endoscope system

A subject irradiated with violet light and green light is imaged to obtain rgb signals, based on which a base image is produced. Frequency filtering processing is applied to the b signal to obtain a blood vessel extraction signal, in which a most superficial blood vessel, a superficial blood vessel, and a middle-layer blood vessel at different depths are extracted.
Fujifilm Corporation

Smart toilet having function of human blood oxygen detection

A smart toilet having a function of human blood oxygen detection is provided. The smart toilet includes a toilet base and a machine body connected to the toilet base.
Zhongshan Anbo Health Technology Co., Ltd.

High protein meal and flour compositions and methods

This invention pertains to the development of a high protein oil seed flour as a replacement for both wheat based and gluten free flours used in baked, dry and liquid goods which optimizes nutrition. The seed flour is based on the novel use of processing sunflower and other oil type seeds into a flour, meal, or protein isolate to replace a significant portion of traditional and gluten free flours in food goods, including baked, dry and liquid goods.

Methods for diagnosing and treating cancer

Disclosed is a method for identifying a subject at risk of developing a recurrent or metastatic cancer, comprising detecting pd-l1+ circulating tumor cells in a blood sample, a tissue fluid sample or a specimen of the subject. Also disclosed is method for treating a cancer comprising identifying a subject having one ore more pd-l1+ circulating tumor cells by detecting pd-l1+ circulating tumor cells in a blood sample, a tissue fluid sample or a specimen of the subject, and administering a treatment to the subject..
Micareo Taiwan Co., Ltd.

Composition for diagnosing pancreatic cancer and diagnosing pancreatic cancer using the same

The present invention relates to: a composition for diagnosing pancreatic cancer, containing a preparation for measuring the expression level of a protein or a gene thereof, and capable of being used for determining whether there is a risk of pancreatic cancer; a kit; and a method for diagnosing pancreatic cancer by using the same. The present invention can significantly predict or identify the risk of pancreatic cancer or a precancerous lesion of pancreatic cancer, the early diagnosis thereof and the extent of diseases thereof by providing a diagnostic marker of pancreatic cancer, and can be utilized in the research of pancreatic cancer oncogenesis.
Seoul National University R&db Foundation

Antibody that specifically recognizes and binds to reic/dkk-3 protein having active structure and monitoring of cancer treatment using such anti-reic/dkk-3 antibody

This invention provides an anti-reic antibody that specifically recognizes a cancer-associated protein (reic/dkk-3) and enables monitoring of cancer treatment effects involving the use of the reic/dkk-3 gene or the reic/dkk-3 protein as a medicine. This invention also provides a method of diagnosis involving the use of such antibody.
Momotaro-gene Inc.

Immunochromatographic test strip and detection method using immunochromatography for detecting object in red blood cell-containing sample

A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions..
Sekisui Medical Co., Ltd.

Methods and devices for assessing cell properties under controlled gas environments

The invention in some aspects relates to high throughput methods and devices for evaluating mechanical, morphological, kinetic, rheological or hematological properties of cells, such as blood cells under regulated gas conditions. In some aspects, the invention relates to methods and devices for diagnosing and/or characterizing a condition or disease in a subject by measuring a property of a cell from the subject, under controlled gas conditions..
Massachusetts Institute Of Technology

Panel of acvs-associated proteins for diagnosis and prognosis

Provided herein are methods of diagnosing and/or treating acvs, by determining expression levels of several acvs-related molecules, such as fabp3, anpr-1, igfbp-3, f9, sell, apob100, adpn, vwf, thbs1, prl, pon3, egfr, vegf-d, hpx, mbt, f5, f10, serpin a5, hcii, and habp2, for example in a blood sample.. .
The Governors Of The University Of Calgary

System and trailing a wounded animal

A system and method of trailing a wounded animal includes sensing a chemical component of mammalian blood and other bodily fluids in the air using a sensing device. The sensing device comprises a housing configured to be held in a hand of a person trailing the wounded animal.

Peripheral measure of central brain inflammation, markers therefor and uses thereof

Provided are methods for determining the level of microglial activation in the brain of a subject by measuring blood prostaglandin e2 (pge2), prostaglandin f2α, or both, and c-reactive protein (crp) concentrations in a sample obtained from a subject, wherein the ratio of [pge2]/[crp], [pgf2α]/[crp], or both, is indicative of the level of microglial activation in the brain of the subject.. .
Centre For Addiction And Mental Health

Allergen detection apparatus using electrochemical detection method

The electrochemical sensor according to the present invention can precisely measure the current value of serotonin by preventing a decrease in sensitivity due to the background in the blood and thus can effectively diagnose allergy.. .
Wonmedical Corp.

Chemiluminescence analyzer, blood purification apparatus, and blood purification system

A chemiluminescence analyzer includes a reactor to cause waste liquid discharged from a blood purification apparatus to react with a reagent solution, a photodetector to measure an intensity of chemiluminescence arising in the reactor, a first liquid conveyor to convey the waste liquid from a waste liquid passage of the blood purification apparatus to the reactor, and a second liquid conveyor to convey the reagent solution to the reactor. The chemiluminescence analyzer further includes a liquid mixture passage extending from the reactor to convey a liquid mixture including the waste liquid and the reagent solution after reaction, a joint to couple the liquid mixture passage to the waste liquid passage of the blood purification apparatus, and an electric interface for connection with an external device..
Ricoh Company, Ltd.

Method and system for rapid parasite detection

The invention described herein relates to a method of detecting malaria comprising the steps of: (i) delivering an evanescent ir beam through said atr substrate in contact with a patient blood sample; (ii) detecting ir radiation transmitted from the atr substrate to produce a signal characteristic for one or more lipids in the sample, and (iii) processing said signal and a set of reference library spectra of lipids associated with malaria parasites in order to detect matches and quantify said one or more lipids in the sample. In contrast to the prior art, the present invention relies on detecting lipids instead of hemozoin..
University Of Melbourne

Real-time intraoperative blood loss monitoring

Fluid introduction into the patient during surgery can be tracked more accurately. For example, saline is often introduced to a patient to clean an operating site.

Methods for diagnosing and evaluating non-alcoholic steatohepatitis

The invention relates to a method for the diagnosis of non-alcoholic steatohepatitis (nash), for determining the activity, the stage, or the severity of nash or for classifying a subject as a potential receiver or non receiver of a treatment of nash using circulating mirnas and other blood circulating markers of liver damage, e.g. Alpha 2 macroglobulin, hba1c, n-terminal pro-peptide of collagen type iii, mir-34 and mir-200.
Genfit

Mass spectrometric diagnosis of sepsis without blood culture

The invention relates to methods and instruments for the rapid detection and rapid mass spectrometric identification of microbial infective agents in blood or other body fluids. The invention recognizes that blood is not a good environment for the cultivation of microbes and provides a method which (a) largely destroys or dissolves the human particles in body fluids, such as erythrocytes and leukocytes in blood, without impairing the ability of the microbes to reproduce, (b) separates the microbial pathogens from the fluid, (c) cultivates them in a nutrient broth which contains none of the antimicrobial components of the body fluids, (d) separates them from the nutrient broth, and (e) identifies the microbes by a mass spectrum of the microbial proteins.
Bruker Daltonik Gmbh

Determining a quantity of an analyte in a blood sample

A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure..
Roche Diagnostics Operations, Inc.

Apparatus and separating and analyzing blood

An apparatus, comprising at least separating means (1) for separating blood plasma and red blood cells, which separating means (1) comprise pressure means (20) for pressing at least a part of the blood through a filter (26), wherein at least first collecting means (27) are provided for collecting separated blood plasma and at least one reagent is provided in said first collecting means (27) or can be introduced therein for reaction with substances or organisms present in said blood plasma.. .
Fabpulous B.v.

Systems and methods for treating cardiac arrhythmias

A leadless pacing device may include a power supply for providing a power supply voltage, a housing having a first end and a second end with a side extending between the first end and the second end, and a set of electrodes supported by the housing and in communication with the power supply. When leadless pacing device is disposed within a coronary sinus of a patient's heart, the housing may facilitate blood flow across the housing.
Cardiac Pacemakers, Inc.

Devices and methods for delivering subtances for improved wellbeing

A method and apparatus to deliver biological altering substances through body cavities including ears, nose, mouth, anus and vagina, utilizing at least osmotic, olfactory and inhaling transfusion of active ingredients includes a first reservoir configured to be disposed against sublingual surfaces and hold a first drug. The device is configured to transmit the first drug through sublingual surfaces into the bloodstream.

Treatment method using catheter assembly and catheter assembly

A treatment method involves introducing a catheter into a blood vessel in an arm of the patient and is advanced to position the distal end of the catheter in a blood vessel in a lower limb on one side of the patient's body. A treatment device is inserted into the catheter and advanced to a treatment target in the lower limb on the one side of the patient's body.
Terumo Kabushiki Kaisha

Apparatus and improved assisted ventilation

Devices and methods for allowing for improved assisted ventilation of a patient. The methods and devices provide a number of benefits over conventional approaches for assisted ventilation.
Colabs, Inc.

Apparatus and the preparation and administration of blood components

A dual chambered syringe includes: an inner barrel defining a first inner chamber, the inner barrel having an apertured stopper at its distal end, the inner barrel being open at its proximal end; a shaft adapted to fit within the inner barrel, the shaft having a distal end which is engageable with the aperture of the stopper; a device for controlling engaging and disengaging of the distal end of the shaft with the aperture of the stopper; an outer barrel concentric with the inner barrel defining a second inner chamber, the outer barrel having a distal end for receiving and dispensing fluids and a proximal end into which the distal end of the inner barrel is insertable into the second inner chamber; the apertured stopper engages the second inner chamber of the outer barrel and selectively prevents or permits the passage of fluids between the outer barrel second chamber and the inner barrel first chamber; the inner barrel having an engageable surface on its outside surface; and, the outer barrel having operatively associated therewith an engaging device for selective engagement and disengagement with the engageable surface on the inner barrel.. .
Genesis Biologics Holdings Ltd.

Control system

A control system controlling the line pressure in a blood supply system (1) in which a pump (14) pumps blood from a reservoir (10) via a primary passage (18) toward a plurality of outlets (16, 26, 26a), wherein one or more outlets are openable to permit flow and closable to block flow, said control system comprises a monitoring arrangement to determine a line pressure in the primary passage, and a controller responsive to the monitoring arrangement and controlling the pump (14) to maintain the line pressure in the primary passage (18) above a pre-set level. The control system practically eliminates the risk of a momentary reduction in blood supply line pressure when an outlet is opened..
Spectrum Medical Ltd.

Methods and systems for the detection and removal of pathogens from blood

The invention relates to methods and systems for removal of pathogens from blood or blood products. The invention further relates to methods and systems for treatment and diagnosis of infection in the blood and/or sepsis in a patient in need thereof..
Stichting Sanquin Bloedvoorziening

Cannula having nitinol reinforced inflow region

An intravascular heart pump assembly can include a rotor with at least one impeller blade, and a cannula. The present application describes various cannulas that can be manufactured from multiple layers of material to improve flexibility, manufacturability, and durability without increasing an outer diameter of the cannula.
Abiomed, Inc.

Catheter system and intravascular blood pump having said catheter system

A catheter (20), which can be part of an intravascular blood pump, possesses a kink sensor which extends over the total length of the catheter and comprises an optical fiber (28a). The optical fiber is attached to an evaluation device (100) which evaluates a preset light quantity transmitted through the optical fiber as to whether a part of the light quantity is coupled out of the optical fiber along the length of the optical fiber.
Abiomed Europe Gmbh

Combined tissue resonance suppression therapy and autologous polyvalent biological vaccine

A method for strengthening the immune response of a weakened immune system, wherein the method includes providing a doses of tissue resonance suppression therapy to a patient and injecting an autologous polyvalent biological vaccine to the patient, wherein the autologous polyvalent biological vaccine was produced from the patient venous blood, a system for performing tissue resonance suppression therapy, a system and a process for the production of the autologous polyvalent biological vaccine for treating cancer, and an autologous polyvalent biological vaccine for personalized and precision medicinal, for treatment of individual cancerous patients, wherein producing a new dose of autologous polyvalent biological vaccine is done from a patient venous blood that was taken after time interval from the time in which a previous venous blood was taken, wherein the vaccine is adapted for treating the individual cancerous patients at a specific stage of his disease, in accordance with embodiments of the present invention.. .

Compositions for biological preparing and using the same

A method of making a composition for influencing biological growth includes obtaining a sample comprising human umbilical cord blood and having a first volume vuc, combining the sample with a quantity of prepacyte-cb or the equivalent having a volume vpc, wherein the ratio vuc/vpcis between about 0.60 and about 1.75 such that a supernatant is formed, layering within a container at least a portion of the supernatant over a layer of a reagent configured for isolating mononuclear cells, the at least a portion of the supernatant having a volume vs and the layer of the reagent having a volume vr, wherein the volume of the layer of the reagent vr is at least 67% the volume vs of the at least a portion of the supernatant, placing a sufficient centrifugal force on the contents of the container to cause at least a new layer substantially comprising mononuclear cells to form, combining at least some of the layer substantially comprising mononuclear cells with lactated ringer's solution or the equivalent to create a mononuclear cell solution, determining the total number of live cells nl in at least a portion of the mononuclear cell solution, the at least a portion of the mononuclear solution having a volume vm, and adding a volume vd of low molecular weight dextran in dextrose solution to the at least a portion of the mononuclear cell solution, the volume vd based at least in part on the total number of live cells nl.. .
Smart Surgical, Inc.

Leukocyte infiltration promoting agent and antitumor immunostimulatory agent

A lysophospholipid receptor-activating substance is able to normalize abnormal blood vessels in tumors without affecting normal blood vessels and to thus induce or promote infiltration of leukocytes into the whole or partial region of a tumor. Therefore, such a lysophospholipid receptor-activating substance is useful as a leukocyte infiltration promoter and an antitumor immunostimulant.
Osaka University

Methods of therapeutic monitoring of nitrogen scavenging drugs

The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods that utilize this technique to adjust the dosage of a nitrogen scavenging drug, determine whether to administer a nitrogen scavenging drug, and treat nitrogen retention disorders.. .
Horizon Therapeutics, Llc

Methods of therapeutic monitoring of nitrogen scavenging drugs

The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods that utilize this technique to adjust the dosage of a nitrogen scavenging drug, determine whether to administer a nitrogen scavenging drug, and treat nitrogen retention disorders.. .
Horizon Therapeutics, Llc

Hybrid dressings of hydrophilic material and polymer foam

Disclosed are hybrid wound dressings that include at least one front layer of a hydrophilic absorbent material and at least one layer behind the front layer that is made of an open-celled polymeric foam made from high internal phase emulsions (hipes). The hydrophilic absorbent material may be a natural polymeric material; a synthetic, non-foam polymer; or a material like glass microfiber.
Dristi Llc

Stent with a smooth surface in its expanded configuration

A coronary stent is disclosed herein as having a lattice configuration on a generally thin-walled cylindrical tube. This particular stent is fabricated using an elongated thin-walled tubular solid that has a diameter equal to that of the final expanded configuration of the stent.

Prosthetic valve for replacing mitral valve

A prosthetic apparatus for implantation in a native mitral valve includes a main body for placement within the native mitral annulus. The main body is compressible to a radially compressed state for delivery into the heart and is self-expandable from the compressed state to a radially expanded state for implantation.
Edwards Lifesciences Corporation

Devices for reducing left atrial pressure, and methods of making and using same

A device for regulating blood pressure between a patient's left atrium and right atrium comprises an hourglass-shaped stent comprising a neck region and first and second flared end regions, the neck region disposed between the first and second end regions and configured to engage the fossa ovalis of the patient's atrial septum; and a one-way tissue valve coupled to the first flared end region and configured to shunt blood from the left atrium to the right atrium when blood pressure in the left atrium exceeds blood pressure in the right atrium. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits.
V-wave Ltd.

Expandable cardiac access catheter

An access catheter provides access for a large bore stiff therapeutic catheter across the atrial septum from above via the superior vena cava. The access catheter has an expandable member that direct a delivery tube outwards in a radial direction to place a delivery tube opening into direct contact with the fossa ovalis.

Methods and removal of intracranial hemorrhage

A system for intracranial access that includes a support assembly is described. The system includes a tubular probe shaft that may be advanced through a hole in the patient's skull.
Penumbra, Inc.

Percutaneous vascular injury treatment systems and methods

The present invention relates to a compressive band and hemostatic dressing system and related methods of use to provide rapid, non-occlusive bleeding control, arterial injury treatment, and injury protection comfortably and reliably after vascular access procedures. The present invention may comprise some or all of the following elements: a positioner assembly, a compressive cushion component, a compression plate, a strap with a flexible hinge assembly, and a hemostatic dressing.
Tricol Biomedical, Inc.

Device and endovascular treatment of aneurysms using embolic eptfe

An embolic occlusion device for the treatment of aneurysms and arteriovenous malformations comprises expanded polytetrafluoroethylene (eptfe). The eptfe permits ingrowth of cells with connective tissue deposition to promote adherence of the aneurysm wall to the embolic device thereby preventing continued growth or re-growth of the aneurysm as well as blocking blood flow into an aneurysm.
Neuravi Limited

Micrograft for the treatment of intracranial aneurysms and use

A device for occluding a vasculature of a patient including a micrograft having an absorbent polymeric structure with a lumen of transporting blood. The micrograft has a series of peaks and valleys formed by crimping.
Neurogami Medical, Inc.

Micrograft for the treatment of intracranial aneurysms and use

A device for occluding a vasculature of a patient including a micrograft having an absorbent polymeric structure with a lumen of transporting blood. The micrograft has a series of peaks and valleys formed by crimping.
Neurogami Medical, Inc.

Blood pressure measurement method, blood pressure measurement apparatus, and terminal

Embodiment provides a terminal which comprises at least one processor. The at least one processor is configured to: obtain first biometric feature information of a measured target, where the first biometric feature information includes a pulse wave signal and/or an electrocardio signal of the measured target; obtain a first status of the measured target according to the first biometric feature information of the measured target; determine blood pressure calculation policy of the measured target according to the first status of the measured target; and determine a blood pressure value of the measured target according to the blood pressure calculation policy and the first biometric feature information of the measured target..
Huawei Technologies Co., Ltd.

A physiological monitoring kit with usb drive

Systems and methods for monitoring a patient with a specific condition by using a kit with monitoring devices and a corresponding memory device for the specific condition. The system comprises a health monitor, and a plurality of monitoring devices for acquiring patient health data.
Koninklijke Philips N.v.

Systems and methods to reduce fluid contamination

Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample to the patient.
Optiscan Biomedical Corporation

Drug detection device

In a first aspect, there is a device for detecting a substance within blood, including a collecting tube dimensioned to draw in blood through capillary action; a reagent chamber containing a reactive element; and a connector tube providing fluid communication between the reagent chamber and the collecting tube; wherein the connector tubes are dimensioned to draw in blood through capillary action to the reagent chamber. In other aspects, the device can include an outer casing and/or a plurality of reagent chambers each with a reactive element therein..

Ketone body concentration estimation device, method, and computer-readable storage medium

An acetone concentration estimate device acquires a measured acetone concentration measuring acetone excreted from a user, acquires an elapsed time which has elapsed since the user ate a meal, and estimates an acetone concentration, which is a ketone body concentration of when an amount of change in blood sugar level of the user per given unit of time is stable, based on the acquired current measured acetone concentration and on the acquired elapsed time, and outputs information corresponding to the estimated acetone concentration.. .
Tanita Corporation

Method for detecting water deficiency in a human body

Determining a state of water deficiency in a human body during daily life activities is done by measuring an impedance of a portion of the human body at a low frequency and at a high frequency. An amount of fluid in the body tissues in the volume under study is assessed based on the impedance at the high frequency.
Healbe Corporation

Blood pressure related information display apparatus

A blood pressure related information display apparatus includes a blood pressure measurement cuff configured to be worn by being wrapped around a measurement site of a measurement subject. An acceleration sensor attached integrally to the cuff is included.
Omron Healthcare Co., Ltd.

A detection device for use in a blood pressure measurement system

Disclosed is a detection device suitable for use with a blood pressure measurement system for detecting improper functioning due to the absence of an inflatable cuff from a patient's measurement site, its improper attachment to the site, or it being disconnected from the system. The device is coupled to an inflatable cuff attached to the measurement site and arranged to perform a series of measurements, wherein for each measurement of the series, an inflation operation is performed to inflate the cuff.
Koninklijke Philips N.v.

Blood pressure estimating apparatus, estimating blood pressure, and non-transitory computer-readable recording medium having stored therein program for estimating blood pressure

A blood pressure estimating apparatus includes: a detecting unit that detects a first parameter representing a period length being a length of a period of a heartbeat of a living body; a processing unit that determines, using the detected first parameter, a change of a volume of at least one vessel among a plurality of vessels that resiliently deform in a mathematical model with respect to time, the mathematical model expressing blood flowing in a circulatory system of the living body with fluid flowing through a flow path formed by annularly coupling the plurality of vessels, and estimates blood pressure of the blood using the determined change and the mathematical model.. .
Tohoku University

Central aortic blood pressure and waveform calibration method

Central systolic and diastolic pressures are measured non-invasively using a peripheral sensor to capture a patient's peripheral pulse waveform. Either the peripheral pulse waveform or a central pressure waveform generated, e.g., using a transfer method is recalibrated to account for differences between non-invasively measured systolic and diastolic pressure and invasively measured systolic and diastolic pressure.
Atcor Medical Pty Ltd

Blood flow meter and measurement device

A blood flow meter capable of measuring the flow rate of the blood flow with high accuracy in a blood vessel of a living body is provided. An element holding body having a tubular shape and having an outer diameter smaller than or equal to the outer diameter of a hollow shaft, which has flexibility and is insertable into a blood vessel, is provided on the distal side of the shaft so as to be coaxial with the shaft.
Nipro Corporation

Vascular elasticity rate evaluation apparatus

To perform measurement of a vascular elasticity rate with high accuracy in a short time. A vascular elasticity rate evaluation apparatus of the present invention includes: a pressure detection unit that detects a pulse wave with an external pressure being applied to a blood vessel; and a control unit that forms a pulse wave amplitude indicating dependent characteristics due to elasticity of the blood vessel from a detection value of the pressure detection unit, calculates a plus area in an elevation process of the pulse wave amplitude and a minus area in a descent process thereof, and calculates the vascular elasticity rate using values thereof..
Sanyoseiko Co., Ltd.

Image processing apparatus and image processing system for displaying information about ocular blood flow

An image processing apparatus includes an identification unit configured to identify a retinal blood vessel based on a retinal image, a measurement unit configured to measure blood flow information for the blood vessel based on the retinal image, and a display control unit configured to display the measured blood flow information by at least one selected from a depth of the identified blood vessel, a size of the identified blood vessel, and a combination of both.. .
Canon Kabushiki Kaisha

Compositions and methods for monitoring biometric indicators

Methods of measurement of biometric indicators in a mammalian subject are described. Biometric indicators of interest include hematocrit, plasma volume, volume of distribution, and glomerular filtration rate.

Medical image processing apparatus, reconstruction method and x-ray diagnostic apparatus

A medical image processing apparatus comprises processing circuitry configured to acquire a first blood vessel image based on x-rays that are irradiated from a first direction and a second blood vessel image based on x-rays that are irradiated from a second direction; determine a corresponding point on the second blood vessel image, which is a point corresponding to a subject point on the first blood vessel image, by using an epipolar line corresponding to the subject point and blood-flow information based on a change of a density of a contrast agent over time at the subject point; and reconstruct a three-dimensional blood vessel image by using information about the subject point and the corresponding point.. .

System for rule-based insurance underwriting suitable for use by an automated system

A system for at least a partial underwriting of insurance policies is described. Various rules are created, along with a degree of satisfaction for each rule.

Biomarkers for seizures

The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood plasma or blood serum of a mammalian subject.

Method for health maintenance monitoring

A method for monitoring health maintenance by collecting an initial blood sample from an individual and dividing the collected blood sample into at least two parts. The first of the two parts is immediately analyzed for multiple blood components levels, and the second part is frozen immediately after the collection to be used at a later time as a comparative standard.

Method to detect blood creatinine and an immunosuppressive drug

The invention provides a method for detecting or quantifying creatinine and an immunosuppressive drug selected from tacrolimus and ciclosporin in a blood sample, devices, including lateral flow assay devices, and kits, as well as methods that enables the reduction of nephrotoxicity and/or enables the maintenance of good renal function in an organ or tissue transplant patient who is undergoing treatment with an immunosuppressive drug selected from tacrolimus and ciclosporin, and methods for monitoring nephrotoxicity and/or kidney function in transplant patients.. .

Facile laboratory localising biomolecules to the surface of cells and viruses

A facile laboratory-based method and kit for use in accordance with the method is disclosed. The method allows for the localisation of biomolecules comprising a conjugatable sulfhydryl group to be localised to the surface of cells, such as red blood cells, as lipid conjugates.

Method and testing immune state

A method is provided capable of testing an immune state in more detail and in a simple and inexpensive manner to identify diseases such as cancer and to identify side-effects of treatment with an anticancer agent and the like, effects of immunotherapy, a state of prognosis, and the like. The method includes: a step of calculating the total number of white blood cells serving as immune cells in a body of a subject and the number of each of immune cell subgroups based on test information on blood counts of blood components and white blood cell images of the subject and analysis information on the cd classification of monoclonal antibodies that bind to surface antigens of white blood cells; and a step of analyzing the immune state of the subject based on a proportion and a change in the numbers of the immune cell subgroups..

Device for spectroscopic detection and monitoring of biologically relevant molecules

There is a need in the point-of-care diagnostic community for an efficient and portable method for testing blood and other biological fluids that can be easily translated across multiple applications. An aspect of the invention described involves monitoring the optical properties of molecularly-mediated nanoparticle assemblies though an optically transparent and magnetically active microfluidic chip, which has recently emerged as an attractive method for biomarker detection as it is an efficient tool for monitoring the binding events that take place in a sensing assay.

Reflectance confocal microscopy of blood cells

Measurement of the three dimensional morphology of blood cells is performed using a model for simulating reflectance confocal images of the cells, providing the relation between cell morphology and the resulting interference patterns under confocal illumination. The simulation model uses the top and bottom membranes of the cell as the elements for generating the interference fringes, and takes into account the cell size, shape, angle of orientation and distance from the focal point of the confocal illumination beam.

Hoxc6 and ovarian cancer methods and uses thereof

The present invention comprises novel methods, systems, devices, and kits to detect cancer in a patient using hoxc6. Methods and systems are presented herein to (1) determine differential gene expression in cancer tissue (e.g.

A culturing cells

A method of culturing autogenous cells as well as a method of treating a mammalian patient is described. The cells are cultured on a substrate material having a surface treated with a fatty acid ester so as to have a strong hydrophobic surface and autogenous plasma obtained from a blood sample of the patient is used as a growth medium in order to culture the cells.

Method for preparing rapeseed oil by semi-solid aqueous enzymatic treatment

The invention discloses a method for preparing rapeseed oil by a semi-solid aqueous enzymatic process, belonging to the field of functional foods and health care products. The present invention first prepares a semi-solid rapeseed paste with 3.5-4.5% moisture content, which is hydrolyzed by a mixture of pectinase, cellulase and alkaline protease to extract rapeseed oil.

Methods and systems for lowering blood pressure through reduction of ventricle filling

Systems and methods for reducing ventricle filling volume are disclosed. In some embodiments, a stimulation circuit may be used to stimulate a patient's heart to reduce ventricle filling volume or even blood pressure.

Safety iv catheter with molded-open blood control valve

A catheter assembly (10) comprising a catheter (18), a needle (12) having a sharp distal tip (13), and a catheter hub (14) connected to the catheter (18) having the needle (12) passing therethrough, the catheter hub (14) including a valve (19) having a preformed opening (22) that selectively permits or blocks a flow of fluid through the catheter (18), a first inner diameter (32) that closes the valve (19), and a second inner diameter (30) larger than the first inner diameter (32), the second inner diameter (30) opening the valve (19), wherein the valve (19) is in an open position upon axially compressing the valve (19) into engagement with the second inner diameter (30) of the catheter hub (14), and the valve (19) is in a closed position upon releasing the valve (19) to engage the first inner diameter (32) of the catheter hub (14).. .

Fluid circuit priming methods, devices, and systems

According to embodiments, priming systems, methods, and devices are disclosed which allow medical treatment devices which pump fluid to be primed with minimal operator intervention and a high level of convenience. A blood circuit with a filter fitted with one or more air vents on a non-blood compartment is attached to a treatment system and priming fluid pumped slowly through the blood circuit in a loop.

Processing blood

Methods (300), devices, and systems of processing blood are described. The method (300) comprises the steps of: obtaining (312) blood from a patient coupled to a single blood processing device to form a closed loop between the patient and the blood processing device; collecting (314) bulk mononuclear blood cells from the blood by leukapheresis implemented using the blood processing device in the closed loop; and enriching (316) concurrently target cells separated from non-target cells in the bulk mononuclear blood cells using the blood processing device in the closed loop..

Systems and methods for separating blood under conditions of reduced plasma clarity

Blood separation systems and methods are provided for separating blood under conditions of reduced plasma clarity. The system may assess plasma clarity by monitoring light transmissivity of plasma or comparing an actual plasma flow rate to an ideal plasma flow rate, with a low flow rate indicating decreased clarity, which may be addressed by increasing the plasma flow rate.

System and method to efficiently clean a blood filter

A renal therapy apparatus includes a blood filter, a blood pump, a treatment fluid pump, and a control unit configured to control at least one of the blood pump or the treatment fluid pump during a filter cleaning sequence. In a first phase of the filter cleaning sequence, a first fluid including a blood-compatible and physiologically safe fluid is transferred back and forth across the insides and/or outsides of the blood filter.

Blood pump controllers having daisy-chained batteries

Systems and related methods for supplying power to an implantable blood pump are provided. A system includes a base module and a plurality of energy storage devices.

Connecting device

A connecting device is provided for connecting a pipe or tube-shaped element to the heart or a blood vessel of a patient, comprising a suture ring that has an opening, which can be closed by means of a closure element and through which said pipe or tube-shaped element is guided in the axial direction. The closure element is secured to the suture ring by means of at least one elastic securing element.

Implantable pump system having an undulating membrane

An implantable pump system is provided, suitable for use as a left ventricular assist device (lvad) system, having an implantable pump, an extracorporeal battery and a controller coupled to the implantable pump, and a programmer selectively periodically coupled to the controller to configure and adjust operating parameters of the implantable pump. The implantable pump includes a flexible membrane coupled to an actuator assembly that is magnetically engagable with electromagnetic coils, so that when the electromagnetic coils are energized, the actuator assembly causes wavelike undulations to propagate along the flexible membrane to propel blood from through the implantable pump.

System architecture that allows patient replacement of vad controller/interface module without disconnection of old module

Mechanical circulatory assist systems and related methods accommodate the connection of a second patient interface module used to control a circulatory assist pump without having to disconnect a first patient interface module used to control the circulatory assist pump. A mechanical circulatory assist system includes a blood pump, a first patient interface module, and a first connector.

Methods and systems for upgrading ventricle assist devices

Methods, systems, and devices for an updatable blood pump are disclosed herein. The blood pump can be part of a mechanical circulatory support system that can include a system controller and the blood pump.

Cavopulmonary viscous impeller assist device and method

A bearingless and sealless rotary blood pump is disclosed which provides multidirectional flow intended to provide low-pressure, high-volume right-sided partial assist circulatory support in a univentricular fontan circulation on a permanent basis. The pump includes a housing and an impeller suspended in the center of the housing.

Portable hand pump for evacuation of fluids

A manually operable pump for the effective removal of fluids to include blood, blood clots, fluid, and air from a body cavity of a subject is provided. The manually operable pump is adapted to be connect to a range of fluid conduits and is equipped with one-way valves that effectively permit flow of fluid through the pump in only one direction.

Nitroxylradical-containing copolymer which has phosphoric acid residue, and the use of the same

Provided is a coating agent which can be stably immobilized on metal surface, and which can give blood compatibility. Provided is a copolymer which is usable as the above-mentioned coating agent that comprises peg segment and a segment which has a phosphoric acid residue (po(—oh)2) and a cyclic nitroxideradical randomly as a side chain or a pendant group..

Method of transporting an agent across blood-brain, blood-cochlear or blood-cerebrospinal fluid barrier

Disclosed here is a method of transporting a therapeutic or diagnostic agent across a blood-brain barrier or a blood-cochlear barrier or a blood-cerebrospinal fluid barrier of a subject, comprising administering to a subject an amount of a therapeutic and/or diagnostic agent, along with an amount of 2,4-disulfonyl a-phenyl tertiary butyl nitrone (2,4-dspbn), said therapeutic and/or diagnostic agent being characterized as being unable or poorly able, in the absence of said amount of 2,4-dspbn, to cross the blood-brain barrier or the blood-cochlear barrier or the blood-cerebrospinal fluid barrier of said subject.. .

Novel insulin analog and use thereof

An insulin analog has a reduced insulin titer and a reduced insulin receptor binding affinity compared to the native form for the purpose of increasing the blood half-life of insulin. A conjugate is prepared by linking the insulin analog and a carrier.

Red blood cell products and the storage of red blood cells in containers free of phthalate plasticizer

Red blood cell products and compositions are disclosed. The product includes a container made from pvc or a non-pvc material that is substantially free of a phthalate plasticizer but otherwise includes one or more non-phthalate plasticizers or extractable agents.

Compositions and methods for treating hiv-associated neurocognitive disorders

The invention pertains to a formulation comprising magnetic nanoparticles (menps) conjugated to or mixed with a therapeutic cargo, the therapeutic cargo comprising an hiv inhibitor, an inhibitor of bace-1 activity or expression, and a cocaine antagonist. In one embodiment, the formulation comprises wa, mir-107, and bd1063.

Fruit extracts

Provided an methods of making an extract of fruit of the solanaceae family wherein fruit is processed to optimise the platelet aggregation inhibiting activity of the extract. The methods involve preparing a start mix of homogenised fruit; separating a water soluble fraction from fruit solids; filtration of the water soluble fraction; and concentration of active agents in the filtration permeate.

Bioeffective krill oil compositions

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and/or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process.

Method of ex vivo cellular growth

The present invention relates generally to an ex vivo method of producing a population of cells and materials for use therewith. More particularly, the present invention is directed to an ex vivo method of generating the growth of a population of blood-derived cells and materials for use therewith.

Non-anticoagulant sulfated or sulfonated polysaccharides

The present invention provides non-anticoagulant sulfated or sulfonated polysaccharides (nasps), which accelerate the blood clotting process. Also provided are pharmaceutical formulations comprising a nasp of the invention in conjunction with a pharmaceutically acceptable excipient and, in various embodiments, these formulations are unit dosage formulations.

Compositions and regulating adipose tissue lipolysis, insulin-resistance, and hyperglycemia

The present application discloses compositions and methods useful for controlling blood glucose and insulin resistance during the acute stress response. It is shown that atglistatin can attenuate glucose excursions and insulin resistance arising from surgical procedures.

Edible composition

Foods or meals high in available carbohydrate such as sucrose or starch increase postprandial blood glucose concentrations. According to node et al.

Nanoemulsion synthetic red blood cells having sequentially formed calcium phosphate coating and preparation method thereof

The present invention relates to nanoemulsion type synthetic red blood cells having a calcium phosphate coating of controllable thickness, and to a preparation method thereof. According to the present invention, ca2+ and po42− coating layers are uniformly and sequentially formed using a layer-by-layer (lbl) coating method while controlling the thicknesses of the coating layers.

Use of inhibitors of bruton's tyrosine kinase (btk)

Disclosed herein are methods for treating a cancer comprising: a. Administering a btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b.

Compounds and methods for repelling blood-feeding arthropods and deterring their landing and feeding

This invention relates to a group of compounds for repelling blood-feeding ectoparasitic arthropods, and a method of deterring their landing and feeding on animals including humans, by applying in one or more formulations compounds that incorporate one or more sulfide and one or more hydroxyl groups to the skin, clothing or environment of animals, including humans. A method of repelling and deterring landing and feeding by blood-feeding arthropods on an animal by applying in effective amount one or more compounds that incorporate alkyl sulfide and alcohol moieties, or alkyl sulfide and amide moieties, or alkyl sulfide and amide moieties to the skin, clothing or environment of an animal..

System and thermal treatment of hypertension, hypotension or aneurysm

A system for treating a patient with general hypertension by increasing a blood flow in the renal artery. The system comprises a hypertension treatment device adapted to have at least one surface of the device placed on the outside of the renal artery to increase the blood flow in the patient's renal region.

Multi-fabric endovascular stent-graft

An endovascular stent-graft is provided that includes a flexible stent member and a tubular fluid flow guide. The tubular fluid flow guide includes first and second fabrics.

Heart valve

A method of deploying a prosthesis within a native mitral valve is disclosed. The expandable frame preferably includes about twelve proximal anchors, wherein the proximal anchors have free ends positioned radially outwardly from the frame in an expanded configuration.

Mitral valve prosthesis delivery system

A heart valve prosthesis delivery system can include a first sheath, a second sheath, a check valve, a check valve control lines, and a heart valve prosthesis carried within the first sheath or the second sheath. The check valve can be carried within the first sheath or the second sheath.

Vascular graft

Provided is an artificial blood vessel including a cylindrical inner tube having a hollow part formed therein; an outer tube provided at an outer circumferential surface of the inner tube and surrounding the inner tube so as to form a double tube structure with the inner tube; and a connecting line formed in circumferential directions of the inner tube and the outer tube to connect the inner tube and the outer tube.. .

Apparatus and collecting reusable material and cleaning surgical instruments

A system and method for cleaning instruments, which provides removal and collection of material from one or more surgical instruments. The cleaning apparatus may be a dry cleaning process or offered in conjunction with one or more fluids.

Systems and methods for risk assessment and treatment planning of arterio-venous malformation

A computer implemented method for assessing an arterio-venous malformation (avm) may include, for example, receiving a patient-specific model of a portion of an anatomy of a patient; using a computer processor to analyze the patient-specific model for identifying one or more blood vessels associated with the avm, in the patient-specific model; and estimating a risk of an undesirable outcome caused by the avm, by performing computer simulations of blood flow through the one or more blood vessels associated with the avm in the patient-specific model.. .

Atherectomy with subintimal space

A method and dissecting device are disclosed for treating a stenotic vessel. The method including inserting a dissecting device into a subintimal space of a blood vessel; dissecting an inner side of the subintimal space from an outer side of the subintimal space over an entire circumference of the blood vessel with the dissecting device, the dissecting device including a first dissecting member having a first cutting member; and removing the dissected inner side of the subintimal space and a stenotic region attached to the inner side of the subintimal space from the blood vessel..

Atherectomy with subintimal space

A method and dissecting device are disclosed for treating a stenotic vessel. The method including inserting a first dissecting member into a subintimal space of a blood vessel and a second dissecting device configured to be received within a lumen within the first dissecting device and inserted into the blood vessel in a bent state; dissecting an inner side of the subintimal space from an outer side of the subintimal space over an entire circumference of the blood vessel with the first dissecting device; and removing the dissected inner side of the subintimal space and a stenotic region attached to the inner side of the subintimal space from the blood vessel..

Atherectomy with subintimal space

A method and dissecting device are disclosed for treating a stenotic vessel. The method including inserting a directional guide member of a dissecting device into a subintimal space from a blood vessel; sliding a tubular cutting member on the directional guide member through the subintimal space; and cutting a stenotic region with the tubular cutting member as the cutting member slides towards a distal end of the directional guide member..

Atherectomy with subintimal space

A method and dissecting device are disclosed for treating a stenotic vessel. The method including inserting a directional guide member of a dissecting device into a subintimal space of a blood vessel, the dissecting device including the directional guide member and a cutting member located proximally to a distal end of the directional guide member; and cutting a stenotic region within the blood vessel with the cutting member while advancing the distal end of the directional guide member through the subintimal space..

Medical device, medical system, and treatment method

A medical device, a medical system, and a treatment method are disclosed, which are capable of effectively crushing an object in a body lumen. The medical device can be used after being inserted into a capturing device capturing thrombi in a blood vessel and removing the thrombi to the outside of a body has at least two elongated shaft portions spaced apart from each other side by side and a cutting unit extending to a distal side from distal portions of at least two shaft portions, the cutting unit has linear portions inclined with respect to the shaft portions and a distal continuous portion extending to the distal side from distal portions of at least two linear portions, and at least the linear portions have sharp cutting blades..

Device and treating vascular occlusion

A system and method for managing an occlusion, such as a blood clot, within a lumen or passageway of a patient. More particularly, a system and method for rapidly restoring blood flow through an occlusion including a self-expanding, tubular member through which blood may flow when in an expanded state.

Minimally invasive thrombectomy

A minimally invasive blood clot capturing invention made of nitinol the nitinol is shaped into a plurality of fingers to form a frame for a basket and funnel to capture and remove blood clots. The basket and funnel being delivered to the blood clot by a catheter.

Medical aspiration system and medical thrombectomy system

The invention relates to a medical aspiration system having a catheter with at least two lumens, wherein a first lumen forms an aspiration lumen which is connected to an aspiration unit for suction removal of substances from a blood vessel through an inlet opening in the aspiration lumen, and a second lumen forms an infusion lumen through which a substance can be supplied to the blood vessel through an outlet opening in the infusion lumen, wherein the outlet opening in the infusion lumen is arranged in a region between the inlet opening of the aspiration lumen and a position proximal to the inlet opening in the aspiration lumen. The invention is characterized in that the infusion lumen is connected to a cooling unit, which supplies a cooled liquid for administration through the infusion lumen..

Blood vessel closure clip and delivery device

A medical device including a shape-memory metallic body comprising a plurality of closed cells with a plurality of terminal cell ends and a plurality of tissue engaging members extending from the shape-memory metallic body, a shaft of each tissue engaging member extending from the terminal cell end at least approximately in a direction of the long axis of the closed cell in an expanded configuration.. .

Microneedle device for interstitial fluid extraction

A microneedle device comprising a hollow microneedle protruding from the rim of an outer open holder can be used for the extraction of interstitial fluid (isf). Dermal isf can be extracted with the microneedle device with minimal pain and no blistering for human subjects.

Method for determining cuff blood pressure

Most automatic cuff blood pressure (bp) measurement devices are based on oscillometry. These devices estimate bp from the envelopes of the cuff pressure oscillations using fixed ratios.

System and monitoring aortic pulse wave velocity and blood pressure

Various embodiments are described herein for a system and a method for monitoring aortic pulse wave velocity and blood pressure. A pulse sensor is located on the exterior of an individual's body at a sensor location that allows acquisition of the pulse signal such that a reflected wave component of the pulse signal is present and allows characterization of reflected wave onset.

System, catheter, and calculating corrected fractional flow reserve

A catheter includes an elongate shaft, a pressure sensor, and a thermistor. The elongate shaft defines a guidewire lumen.

Strain sensor element and blood pressure sensor

A strain sensor element comprises a laminated film which has a magnetic free layer, a spacer layer, and a magnetic reference layer. The free layer has a variable magnetization direction and a out-of-plane magnetization direction.

Penis support device to promote constant unrestricted blood flow into the human penis

A men's penis support device includes a pair of men's underwear and at least one elastic strap attached to an interior front of the men's underwear. A proximal and a distal end of the strap are attached to the underwear to create a center opening, wherein the opening holds a wearer's penis in a substantially horizontal position to a left or right direction.

Endovascular method and apparatus with electrical feedback

An apparatus for delivering energy, and in particular laser energy, to a tissue is adapted to minimize or eliminate burn back caused by contact between the energy delivery apparatus and bodily fluids by (i) preventing the energy delivery apparatus from contacting bodily fluids or tissues that might burn or cause the apparatus to burn; and/or (ii) monitoring the apparatus to detect overheating in order to withdraw the apparatus or control the energy supply in case overheating is detected. The apparatus is applicable, by way of example, to treatment of blood vessels using endovascular techniques..
Klemm+sohn Gmbh & Co. Kg

Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device

Embodiments of the invention provide swallowable devices, preparations and methods for delivering therapeutic agents within the gi tract such as neutralizing proteins (np) particularly antibodies which neutralize interleukins. Many embodiments provide a swallowable device e.g., a capsule for delivering various agents into the intestinal wall (iw).
Klemm+sohn Gmbh & Co. Kg

Multi-echo spin-, asymmetric spin-, and gradient-echo echo-planar imaging mri pulse sequence

An echo planar imaging technique in which a quadruple echo gradient and spin echo echo-planar imaging pulse sequence is utilized. The pulse train includes generation of two echo trains between an excitation pulse (90) and a refocusing pulse (180) to achieve two gradient echo images (also called t2*-weighted images); with one echo train directly after the 180 pulse, leading to asymmetric spin echo images (t2′-weighted images); and a last echo train afterward that generates spin echo images (t2-weighted).
The Regents Of The University Of California

Method for assisting determination of type iii hyperlipidemia

Disclosed is a method of distinguishing type iii hyperlipidemia in the who-classified hyperlipidemia types (hereinafter referred to as type iii) from other types of hyperlipidemia, which is a simpler method and has a higher diagnostic efficiency than conventional methods. The method of assisting the determination of type iii hyperlipidemia includes the steps of: measuring the apob-48 value, tg value and ldl-c value in a blood sample isolated from a living body; and calculating a ratio of the apob-48 value divided by the tg value and a ratio of the apob-48 value divided by the ldl-c value.
Fujirebio Inc.

Microfluidic chip-based, universal coagulation assay

A microfluidic, chip-based assay device has been developed for measuring physical properties of an analyte (particularly, whole blood or whole blood derivatives). The technologies can be applied to measure clotting times of whole blood or blood derivatives, determine the effects of anticoagulant drugs on the kinetics of clotting/coagulation, as well as evaluate the effect of anticoagulant reversal agents.
Persophere Technologies Inc.

Biochemical predictors of red blood cell quality

Compositions and methods for determining post-transfusion survival or toxicity of red blood cells and the suitability of red blood cell units for transfusion by measuring the levels of one or more compounds in a red blood cell sample are provided.. .
Bloodworks

Pcr-based counting circulating tumor cells

Disclosed are pcr-based methods for enumerating circulating tumor cells in a blood or lymphatic fluid sample. The cell sample may or may not be enriched for the circulating tumor cells.

Microfluidic isolation of tumor cells or other rare cells from whole blood or other liquids

Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood, the system employs multiple parallel meandering channels having a width on the order of 1-2 cell diameters. The microdevices can be produced at low-cost, may readily be automated, and in many instances may be used without pre-processing of the sample.
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College

Preprocessing apparatus and analysis system comprising the preprocessing apparatus

Disclosed herein is a preprocessing apparatus that makes it possible to highly efficiently analyze specimens held by solid media, such as dried blood spots to be used for newborn mass screening or the like. The preprocessing apparatus includes: a preprocessing container setting part in which a preprocessing container containing a solid sample including a specimen to be analyzed and a solid medium holding the specimen is to be set; a carrying mechanism that carries the preprocessing container set in the preprocessing container setting part; and a preprocessing part that has a port for setting the preprocessing container carried by the carrying mechanism and that is configured to perform preprocessing including extraction processing for extracting the specimen from the solid sample contained in the preprocessing container set in the port..
Shimadzu Corporation

Biomarkers in peripheral blood mononuclear cells for diagnosing or detecting lung cancers

Methods and compositions are provided for diagnosing or detecting a condition, e.g., lung disease in a mammalian subject by use of a micro-rna expression level or an expression level profile of multiple mirna in the peripheral blood mononuclear cells (pbmc) of the subject which is characteristic of copd or nsclc. Detection of changes in expression in specific mirna biomarkers from that of a reference sample or mirna expression profile are correlated with non-small cell lung cancer (nsclc) and/or copd and permit differentiation among healthy subjects, subjects with copd and subjects with adenocarcinoma or squamous cell carcinoma..
The Wistar Institute Of Anatomy And Biology

Biomarker panel for diagnosis and prediction of graft rejection

Methods are provided for monitoring a subject having a graft for an acute rejection (ar) response, e.g., to predict, to diagnose, and/or to characterize an ar response. In practicing the subject methods, the expression level of at least one gene in a sample from the subject, e.g., a blood or biopsy sample, is evaluated, e.g., at the nucleic acid and/or protein level, to monitor the subject.
The Board Of Trustees Of The Leland Stanford Junior University

Mitochondrial health parameters as clinical predictors of parkinson's disease

Methods are disclosed for detecting peripheral mitochondrial dna damage and dysfunction. Methods are also disclosed that utilize blood samples to detect a neurodegenerative disease, such as parkinson's disease, and determine the efficacy of therapy..
University Of Pittsburgh - Of The Commonwealth System Of Higher Education

Use of mirco-rnas circulating in the blood serum or blood plasma for identifying patients requiring a biopsy and as a marker for the differential diagnosis of individual non-ischemic cardiomyopathies or storage diseases

The invention relates to the use of certain micro-rnas circulating in the blood serum or blood plasma in the form of diagnostic profiles as a marker in an in vitro method for distinguishing between patients for which a myocardial biopsy is necessary for the diagnostic identification of a heart muscle disease and patients for which myocardial biopsy is not necessary, and for the optional differential diagnosis of individual non-ischemic cardiomyopathies or storage diseases affecting the heart.. .
Ikdt Institut Kardiale Diagnostik Und Therapie Gmbh

Methods for isolating microbial cells from a blood sample

This disclosure relates to methods for isolating bacterial cells, fungal cells, and single-celled parasites present in a blood sample containing higher eukaryotic cells; particularly wherein the microorganisms are present at a concentration significantly lower than the eukaryotic cells in the sample.. .
Bacteria Detection Ltd

Targeting micrornas for metabolic disorders

Provided herein are methods and compositions for the treatment of metabolic disorders. Also provided herein are methods and compositions for the reduction of blood glucose level, the reduction of gluceoneogenesis, the improvement of insulin resistance and the reduction of plasma cholesterol level.
Eth Zurich

Systems for producing cellular immunotherapeutics and methods of use thereof

Devices, systems, and methods can be used for the automated production of dendritic cells (dc) from dendritic cell progenitors, such as monocytes obtained from peripheral blood, and the automated generation of immunotherapeutic products from those dendritic cells, all within a closed system. The invention makes it possible to obtain sufficient quantities of a subject's own dc for use in preparing and characterizing vaccines, for activating and characterizing the activation state of the subject's immune response, and to aid in preventing and/or treating cancer or infectious disease..
Northeastern University

Methods and compositions for increasing iduronate 2-sulfatase activity in the cns

Provided herein are methods and compositions for treating a subject suffering from a deficiency in iduronate 2-sulfatase in the cns. The methods include systemic administration of a bifunctional fusion antibody comprising an antibody that crosses the blood brain barrier (bbb) and an iduronate 2-sulfatase..
Armagen, Inc.

Dna binding agents with a minor groove binding tail

Provided herein are compounds which intercalate into the dna of a cell and are capable of crossing the blood brain barrier of a formula provided herein. Pharmaceutical compositions of the compounds and methods of treating cancer, for example brain, lung, or pancreatic cancer, are also provided herein..
Board Of Regents, The University Of Texas System

Systems and methods for coordinating musculoskeletal and cardiovascular or cerebrovascular hemodynamics

Described herein are methods for determining a target musculoskeletal activity cycle (mskc) to cardiac cycle (cc) timing relationship. The method may include detecting a signal responsive to a cyclically-varying arterial blood flow at a location on a head of a user; providing a recurrent prompt at a frequency of the heart pump cycle using the signal, such that the signal correlates with a magnitude of blood flow adjacent to the location, and the recurrent prompt is provided to guide the user to time performance of a component of a rhythmic musculoskeletal activity with the recurrent prompt; and guiding the user to adjust a timing of the component of the rhythmic musculoskeletal activity to substantially maximize a magnitude of the signal.
Pulson, Inc.

Closed peripheral intravenous catheter with safety system cpivcss

The present invention refers to a system for placing an intravenous catheter, specifically a closed system for placing an intravenous catheter which prevents exposure by medical personnel to the patient's bodily fluids during the placement of the catheter; and with a retractable needle cannula in a manual billows mechanism for preventing its reuse, accidental puncture wounds and assuring safe disposal. This cpivcss has the advantages of (a) preventing medical personnel from being exposed to the contaminated bodily fluids or blood during the placing of the catheter in the patient; (b) reducing the possibility of multiple punctures and; (c) having an easily usable safety system.
Equipos Medicos Vizcarra S.a.

Control system

A control system controlling the blood flow rate in a blood supply system (1) in which a pump (18) transports blood from a reservoir (10) toward multiple outlets (30, 26, 26a) of which one or more outlets are openable to permit flow and closable to block flow, wherein the control system comprises a monitoring arrangement (22, 32, 32a) to determine the flow rate through a first outlet (30), and a controller responsive to the monitoring arrangement and controlling the pump (18) to maintain the flow rate through the first outlet (30) at a pre-determined level. This allows a flow rate through the first outlet to be maintained independently of any active blood diversions..
Spectrum Medical Limited

Device and extracorporeal blood treatment

A device for extracorporeal blood treatment includes a balancing system and calculates an ultrafiltration volume (ufd) as a volume withdrawal on the basis of a pressure difference (Δp) and a temperature difference (Δt) at an inlet and an outlet of at least two balance chambers. To this end, pressure sensors are arranged directly behind an inlet and an outlet of the at least two balance chambers, respectively, and determine a fluid pressure at their respective position, and temperature sensors are arranged at inputs of the at least two balance chambers and determine a temperature in the inlet and the outlet of the balance chamber.
B. Braun Avitum Ag

Energy management of blood pump controllers

Systems and related methods for supplying power to a medical device employ self-charging serially-connectable portable batteries. A system includes a base module and external battery modules.
Tc1 Llc

Blood pump controllers and methods of use for improved energy efficiency

Methods, systems, and devices for a mechanical circulatory support system are disclosed herein. An implantable power supply can be part of a mechanical circulatory support system.
Tc1 Llc

Artificial heart system

A blood pump system includes two blood pumps, which may be implanted into a patient. The blood pumps may comprise vad pumps.
Reliantheart Inc.

Blood mixer for a blood collecting bag

A blood mixer comprises a support structure supporting the components of the mixer (10), a tubing fastening and guiding arrangement, configured to secure a blood collecting tubing in the mixer (10), a tray (18) adapted to house a blood collecting bag (16) having a blood tube (14) attached thereto, and configured to measure the weight of the collected blood in the blood collecting bag (16) and a pump (20) configured to draw blood from the donor (12) to a blood collecting bag (16) through said tubing (14). The pump (20) is configured to exert a kneading action on the blood supply tubing (14) by means of at least two kneading elements arranged to alternatingly displace the contents of the tube in the direction towards the bag (16).
Conroy Medical Ab

In situ forming hemostatic foam implants

Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams.
Arsenal Medical, Inc.

Compositions derived from placenta and methods of producing the same

Compositions comprising perforated, unseparated amnion/chorion; perforated, separated amnion; and perforated, separated chorion derived from the placenta and methods of preparing and using those compositions are provided. Perforation of placental tissue before or during processing may allow for one or more benefits such as more efficient removal of blood remnants, retention of wound healing and tissue regeneration components, better handling characteristics, or improved healing capacity.
Stimlabs Llc

Methods, compounds and compositions for modulating blood brain barrier integrity and re-myelination

Disclosed herein are methods and compositions for increasing and decreasing the permeability of the blood brain barrier for the treatment of diseases and conditions and to facilitate the delivery of agents to the brain, as well as methods and compositions for promoting re-myelination and preventing de-myelination. Compositions include rgma, soluble rgma, and functional fragments and variants thereof, rgmc, soluble rgmc, and functional fragments and variants thereof, and neogenin peptides including 4ig..
University Health Network

Treatment of cancer by infusion of oncolytic herpes simplex virus to the blood

An oncolytic herpes simplex virus is disclosed for use in a method of treating cancer in a human subject, the method comprising administering to the human subject at least one dose of oncolytic herpes simplex virus by infusion to the blood, wherein the oncolytic herpes simplex virus reaches cells of the cancer in which it replicates.. .
Virttu Biologics Limited

Lithium stimulation of cord blood stem cell proliferation and growth factor production

The present invention provides methods for expanding human umbilical cord blood stem cells and methods for stimulating growth factor production by cord blood stem cells using an in vitro cell culture system comprising a lithium salt. The present invention also provides in vivo methods for enhancing the survival and growth of transplanted cord blood stem cells by treating the cells with a lithium salt prior to transplantation.
Rutgers, The State University Of New Jersey

Method of repairing damaged blood-spinal cord barrier (bscb)

The disclosure provides methods of administering a composition comprising human bone marrow cd34+ (hbm34+) cells to a mammal in need thereof, whereby vascular damage in the blood-central nervous system barrier (b-cns-b), such as in the blood-spinal cord barrier, of the mammal is repaired. The disclosure also provides a method of treating amyotrophic lateral sclerosis (als) in a mammal by administering a composition comprising human bone marrow cd34+ cells (hbm34+)..
University Of South Florida

Methods for rejuvinating red blood cells

Methods and a system for transfusing blood to a mammalian subject. The method includes obtaining a volume of donated red blood cells (rbcs), adding an enhancement composition to the rbcs to form a treated blood composition, incubating the treated blood composition to form an incubated blood composition, and administering the incubated blood composition to a patient.
Biomet Biologics, Llc

Tumor infiltrating lymphocytes for treatment of cancer

Tumor infiltrating lymphocytes (tils) are white blood cells that are actively recruited to the tumor site to mount an immune response against tumor growth and metastasis. The disclosure provides methods for treating cancer that comprise steps of isolating cd8+ t cells from a sample derived from a subject, expanding the cd8+ t cells in the presence of interleukin-10, and administering the expanded cd8+ t cells to the subject.
Duke University

Nitric oxide-releasing prodrug molecule

Provided are a type of compounds that can be used for treating cardiovascular diseases and compositions containing the compounds. The compounds and the compositions can improve lipid metabolism disorders by increasing high-density lipoprotein cholesterol in blood; in addition, the compounds and the compositions can also release nitric oxide, and reduce the onset risk of cardiovascular diseases by means of relaxing blood vessels, lowering blood pressure, inhibiting platelet adhesion and aggregation and maintaining vascular tension, and thus play an important role in preventing and treating the occurrence and development of cardiovascular diseases..
Shanghai Synergy Pharmaceutical Sciences Co., Ltd

Method of treatment and device for the improved bioavailability of leukotriene receptor antagonists

Disclosed is a method of administration and device for the improved bioavailability of leukotriene receptor antagonists. This method and device involve an alkaline surface ph oral film dosage form designed to deliver leukotriene receptor antagonists, such as montelukast, to the stomach in an amorphous precipitate suspended in aqueous medium.
Intelgenx Corp.

Systems and methods for treating eye diseases using retrograde blood flow

A method, device, or system for treating eye disorders or conditions, comprising restoring or increasing blood flow or blood flow rate in an artery that supplies blood to or in the eye, thereby increasing the amount of nutrient(s) that reaches the eye or a portion thereof. The invention also includes methods, devices, or systems for treating eye disorders or conditions which use reverse flow or retrograde flow structures and systems during the treatment of the eye disease..
J.d. Franco & Co.

Systems and methods for treating eye diseases using retrograde blood flow

A method, device, or system for treating eye disorders or conditions, comprising restoring or increasing blood flow or blood flow rate in an artery that supplies blood to or in the eye, thereby increasing the amount of nutrient(s) that reaches the eye or a portion thereof. The invention also includes methods, devices, or systems for treating eye disorders or conditions which use reverse flow or retrograde flow structures and systems during the treatment of the eye disease..
J.d. Franco & Co.

Methods, systems and devices for cardiac valve repair

Disclosed are methods, systems, and devices for the endovascular repair of cardiac valves, particularly the atrioventricular valves which inhibit back flow of blood from a heart ventricle during contraction. The procedures described herein can be performed with interventional tools, guides and supporting catheters and other equipment introduced to the heart chambers from the patient's arterial or venous vasculature remote from the heart.
Evalve, Inc.

Transcatheter mitral valve design

A prosthetic mitral valve includes a collapsible and expandable stent extending from an inflow end to an outflow end. A collapsible and expandable valve assembly is disposed within the stent.
St. Jude Medical, Cardiology Division, Inc.

Device and hemostasis at the puncture sites of patients' blood vessels as well as an evaluation unit having a sensor

The invention relates to a device and a method for stopping bleeding at the puncture sites of vessels of patients undergoing an extracorporeal treatment, in particular dialysis. The device has a controller which controls the introduction of fluid into an expandable chamber arranged on a strip-shaped basic element and/or draining from the chamber.
Fresenius Medical Care Deutschland Gmbh

Devices and methods for treating acute kidney injury

A catheter devices/systems and methods therefrom are described herein for treating acute kidney injury, especially the contrast-induced acute kidney injury wherein the devices may prevent the contrast dyes from entering into kidney and/or facilitate blood flow of kidney by said catheter system.. .
Renalpro Medical, Inc.

Devices and methods for excluding the left atrial appendage

Devices and methods are described for occluding the left atrial appendage (laa). The device excludes the laa from blood flow to prevent blood from clotting within the laa and subsequently embolizing, particularly in patients with atrial fibrillation.
Conformal Medical, Inc.

Systems and methods for surgical tracking and visualization of hidden anatomical features

This invention provides systems and methods for using spatially localized sensor data to construct a multi-dimensional map of the location of key anatomical features, as well as systems and methods for utilizing this map to present location-based information to the surgeon and/or to an automated surgical navigation system. The location map is updated during surgery, so as to retain accuracy even in the presence of muscle-induced motion or deformation of the anatomy, as well as tissue location changes induced by translations or deformations induced by surgical dissection, surgical instrument contact, or biologically-induced tissue motion associated with activities such as respiration, anesthesia-induced gag reflex, blood flow/pulsation, and/or larger-scale changes in patient posture/positioning..
The Charles Stark Draper Laboratory, Inc.

Device, estimating the energy expenditure of a person

The present invention relates to a device for accurately estimating the energy expenditure of a person, in particular by which the effect of cardiovascular drift is taken into account. The device comprises an input unit (10) for obtaining a movement signal (13) representing physical activity of the person and a heart rate signal (15) representing the heart rate of the person, a cardiovascular drift determination unit (16) for determining cardiovascular drift phases (17) from said movement signal (13) and either said heart rate signal (15) and/or one or more cardiovascular drift related signals (23) carrying information on one or more of amount of sweat, weight loss, temperature rise, blood lactate concentration and physical fatigue of the person, a correction unit (18) for correcting the heart rate signal (15) generated and representing the heart rate during a cardiovascular drift phase, and an estimation unit (20) for estimating the energy expenditure of the person from the corrected heart rate signal (19)..
Koninklijke Philips N.v.

Apparatus and creating a stable optical interface

A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location.
Masimo Corporation

Device and monitoring and diagnosing the autoregular mechanism of the blood ...

A method of monitoring and/or diagnosing an autoregulation mechanism of blood pressure of a living being using an ecg signal includes recording the ecg signal of the living being, and the recording a pulse wave curve synchronously with the recording of the ecg signal. Heart rate intervals are determined from the ecg signal.
Schwarzer Cardiotek Gmbh

Non-invasive brachial blood pressure measurement

A method of measuring a patient's systolic and diastolic brachial blood pressure non-invasively with a brachial cuff considers the shape of a patient's peripheral waveform (e.g., the cuff volumetric displacement waveform) to recalibrate the height of the waveform. The maximum and minimum values of the recalibrated waveform correlate to and closely estimate counterpart values for invasively measured brachial systolic and diastolic pressure..
Atcor Medical Pty Ltd

Clothing having anion-emitting silicone patch attached thereto and manufacturing same

The present invention relates to clothing having an anion-emitting silicone patch attached thereto and a method for manufacturing same. The clothing having an anion-emitting silicone patch attached thereto according to the present invention comprises: clothing; and a silicone patch which is adhered to the clothing and emits anions, wherein the silicone patch comprises anion ore powder and is adhered to clothing by seamless welding at a temperature ranging from 170 to 180° c.
Enerskin Inc.

Compositions and methods of use pertaining to insecticide

The invention provides an aqueous insecticide comprised of at least one surfactant, a preservative, e.g., preservative, for example a potassium salt, sodium chloride in proportions similar to proportions normally detected in mammalian blood, a nutrient source, an organic acid capable of lowering the ph of the aqueous insecticide, fragrance, and water, for the control of cimex, e.g., cimex lectularius (bed bugs).. .

Device for preserving blood products and cellular cultures in a gas medium under pressure

A device that can be used to store blood product and/or cellular culture that may or may not be under pressure. The device includes a chamber that can be hermetically sealed and a flexible secondary bag which can be placed in the chamber.
Rich Technologies Holding Company, Llc

Carbon dioxide removal system

An extracorporeal blood treatment system including a gas exchange module operatively associated with a gas supply unit and optional pump for removing co2 from blood. The gas exchange module includes a plurality of short conduits that are uniquely configured and arranged in a gas exchange mat to for efficient co2 diffusion under conditions of low blood flow..
Innovaplant Zierpflanzen Gmbh & Co. Kg

Apparatus for quantifying and displaying a patient`s time buffer, blood treatment apparatus and method

An apparatus configured to quantify and display a time buffer for at least one patient during a blood treatment session is described. A blood treatment apparatus which includes such an apparatus or is in signal communication therewith, and a method for quantifying and presenting the time buffer for at least one patient at a blood treatment session are also described, as well as a computer program, a computer program product and a digital storage medium..
Fresenius Medical Care Italia S.p.a

Method, system and computer programs for handling remote control of a cooking appliance to provide a customized diet

A method and a system for handling remote control of a cooking appliance to provide a customized diet. The method comprising performing following steps by a cloud computer server: storing one or more recipes including food preparation parameters for one or more cooking appliances; receiving one or more parameters of a plurality of users acquired by at least one measuring device, such as glucose level, blood level, weight, body mass index, temperature, and/or heartbeat; creating a customized diet plan for each of said plurality of users based on the received one or more parameters and the stored recipes; receiving identification data of a particular cooking appliance of a user of said plurality of users; and transmitting control instructions comprising a recipe, as a part of the diet plan, to an information interface integrated in said particular cooking appliance of said user or in a communications terminal of said user..
Taurus Research And Development, Slu

Biochemical markers of red blood cell storage and toxicity

Compositions and methods for determining post-transfusion survival or toxicity of red blood cells and the suitability of red blood cell units for transfusion by measuring the levels of one or more markers in a red blood cell sample are provided.. .
Bloodworks

Means and methods for monitoring inflammation

The application discloses methods, kits and a novel biomarker to detect and/or to prognose inflammation in patients. The diagnostic test is based on measuring the ratio of galactosylated and non-galactosylated specific n-glycans as obtained by enzymatic treatment of the total mixture of proteins present in a body fluid such as blood, serum or plasma..
Universiteit Gent

Use of circulating cell biomarkers in the blood for detection and diagnosis of diseases and methods of isolating them

A new sensitive cell biomarker of solid tumors and viral infection is identified in blood. This biomarker can be used to determine presence of carcinomas, sarcomas, and viruses, rapid determination of treatment response, early detection of cancer, early detection of cancer recurrence, and may be used to determine therapy..
Creatv Microtech, Inc.

Methods and materials for assessing immune system profiles

This document provides methods and materials involved in assessing immune system profiles. For example, methods and materials for performing flow cytometry to determine the number of cd4+ lymphocytes, cd8+ lymphocytes, regulatory t cells, b cells, nk cells, granulocytes, cd14+hla-drlo/neg g monocytes, and/or cd86+ monocytes per unit volume (e.g., cells per μl or ml) of whole blood (e.g., fresh, un-manipulated whole blood) obtained from a mammal (e.g., a human) are provided..
Mayo Foundation For Medical Education And Research

Method for assessing cell surface receptors of blood cells

The present invention relates to a novel method for rapid assessment of one or more subclasses of blood cells of interest (bcol), as for example cd4+ cells and cd8+ cells, in a liquid whole blood sample or a sample derived therefrom; a method of determining the cell count for such cells; a method for determining the cd4/cd8 ratio; a method for determining the quantity of such receptors in a sample; as well as a vertical flow assay device for performing such assessment.. .
Gentian Diagnostics As

Reagent and measuring thrombin-antithrombin complex

Provided is a reagent for assaying a thrombin-antithrombin complex (tat) in a blood sample from a subject by latex agglutination assay. The reagent includes a polycation.
Lsi Medience Corporation

Method and device for assigning a blood plasma sample

A device and method for assigning a blood plasma sample to a class from a predetermined set of classes are presented. The set of classes comprises a good class, a lipemic class, a hemolytic class and an icteric class.
Roche Diagnostics Operations, Inc.

Operation and verification of a portable clinical analysis system

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof..
Abbott Point Of Care Inc.

Mvd as epigenetic marker for the identification of immune cells, in particular cd56+ nk cells

The present invention relates to a method, in particular an in vitro method, for identifying cd56+ nk cells, comprising analyzing the methylation status of at least one cpg position in the mammalian gene region for mevalonate (diphospho) decarboxylase (mvd), wherein a demethylation or lack of methylation of said gene region is indicative for a cd56+ nk cell, when compared to a non-cd56+ nk cell. The analyses according to the invention can identify cd 56+ nk cells on an epigenetic level and distinguish them from all other cells in complex samples, such as, for example, other blood or immune cells.
Epiontis Gmbh

Processes and kits for identifying aneuploidy

Provided are methods for identifying the presence or absence of a chromosome abnormality by which a cell-free sample nucleic acid from a subject is analyzed. In certain embodiments, provided are methods for identifying the presence or absence of a fetal chromosome abnormality in a nucleic acid from cell-free maternal blood..
Sequenom, Inc.

Engineered polypeptides

Provided herein are polypeptides that bind to a blood-brain barrier (bbb) receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a bbb receptor-expressing cell, e.g., for transport across the bbb. Also provided herein are transferrin receptor (tfr) constructs that comprise a monomeric tfr apical domain or one or more portions of the tfr apical domain which have been circularly permuted relative to the full-length tfr sequence..
Denali Therapeutics Inc.

Composition for treating diabetes or diabesity comprising oxyntomodulin analog

Disclosed are a composition for preventing or treating diabetes, disbesity or diabetic complications, containing an oxyntomodulin analog as an active ingredient and a method for treating diabetes, diabesity or diabetic complications, including administering a pharmaceutically effective amount of an oxyntomodulin analog to a subject. The oxyntomodulin analog shows a greater activity to activate a glp-1 receptor and a glucagon receptor, than native oxyntomodulin.
Hanmi Pharm. Co., Ltd.

Treatment of multiple sclerosis and psoriasis using prodrugs of methyl hydrogen fumarate

Improved methods of treating multiple sclerosis and/or psoriasis using prodrugs of methyl hydrogen fumarate are disclosed. The methods comprise administering certain prodrugs of methyl hydrogen fumarate.
Xenoport, Inc.

Apparatus for treating blood vessels in skin

A system and method for treating vessel in skin is disclosed. The system may include two or more electrodes that may be inserted in skin to deliver electrical signal to target vessel therein, an electrical signal generator electrically coupled to the plurality of electrodes, and a power supply unit for supplying power to the electrical signal generator.

Medical device for sensing and or stimulating tissue

Devices, methods and systems for transmitting signals through a device located in a blood vessel of an animal, for stimulating and/or sensing activity of media proximal to the device, wherein the media includes tissue and/or fluid.. .

Inflatable intravascular electrode supports for neuromodulation

An intravascular catheter is positionable within a blood vessel for use in transvenous stimulation of targets external to the wall of the blood vessel. The catheter includes a catheter body, a support at the distal end of the catheter body, and a plurality of electrodes carried by the support.
Neurotronik Ip Holding (jersey) Limited

Detection and interruption devices for infusion leakage and the monitoring system thereof

An infusion-leakage detection device includes: a substrate; a circuit with an infusion-leakage detection region formed on the substrate and aligned to an iv catheter which is inserted into a blood vessel of a patient, and the region includes at least a light-emitting element emitting a light with wavelength within the second optical window of biological organization and at least a light detector receiving the light to generate an electrical signal; and a circuit and battery region formed on the substrate, including a control and calculation unit connecting to the light-emitting element, and an acceleration detector connecting to the control and calculation unit, sensing body movement of a patient and providing a body-movement signal to the control and calculation unit. A remote monitoring system including the infusion-leakage detection device and remote equipment which receive information of leakage/no-leakage and alarm signal to monitor infusion-leakage status remotely..
Spectronik Medical Inc.

Blood treatment apparatus

The present invention relates to a blood treatment apparatus having an extracorporeal circuit, having a dialyzate circuit and having a dialyzer which has a blood-side chamber and a dialyzate-side chamber which is separated from the blood-side chamber by a membrane, characterized in that the blood-side chamber is in fluid communication with the extracorporeal circuit and the dialyzate-side chamber is in fluid communication with the dialyzate circuit, and having a preparation unit for the online preparation of a solution, characterized in that the blood treatment apparatus has first means for carrying out a priming mode and has second means for carrying out an initial treatment mode, wherein the first means are configured such that they control the preparation unit such that a flushing solution having a ph of ≥7.3, and preferably of ≥7.4, is prepared and such that the extracorporeal circuit is filled with this flushing solution, and the second means are configured such that they control the preparation unit such that dialyzate having a ph of ≥7.3, and preferably of ≥7.4, is prepared, and such that the dialyzate circuit is filled with this dialyzate, wherein the blood treatment apparatus has a control or regulation unit which operates the first means before the second means.. .
Fresenius Medical Care Deutschland Gmbh

Methods and compositions for improving antiangiogenic therapy with anti-integrins

Described here are methods and compositions for treating tumors and metastases that improve anti-angiogenesis therapy. By inhibiting these mechanisms in a biological system with an anti-beta one integrin composition in combination with an antiangiogenic composition, tumors and metastases may be deprived of an adequate blood supply, thereby resulting in tumor cell growth arrest and possibly regression, including tumor cell death.
The Regents Of The University Of California

Methods for treating and/or limiting development of diabetes in subjects with amyotrophic lateral sclerosis

Methods for treating and/or limiting development of diabetes in a subject with amyotrophic lateral sclerosis (als) by inhibiting igg-mediated activation of voltage-gated calcium channels (vgccs) in cells of the subject, by one or more of removing igg from blood of the subject, blocking igg from activating vgccs in the subject; or blocking vgccs in the subject are described, as are methods for identifying als patients at risk of developing diabetes.. .
Biocrine Ab

High osteocalcin microcrystalline hydroxyapatite for calcium supplement

An improved manufacturing process produces microcrystalline hydroxyapatite with sustained gradual calcium release that avoids spiking in blood calcium levels. Although the improved material did not cause significant elevation of blood calcium, it was just as effective in promoting bone mineralization as conventional calcium supplements.
Waitaki Biosciences

Umbilical cord-derived adhesive stem cells, preparation method therefor, and use thereof

Disclosed are enhanced umbilical cord-derived adhesive stem cells, a preparation method therefor, and a use thereof. The enhanced umbilical cord-derived adhesive stem cells have an anti-inflammatory effect, a blood vessel regeneration effect, or a nerve regeneration effect, thereby being usable in a pharmaceutical composition or a cell therapeutic agent for treating or preventing various diseases..
Cha Biotech Co., Ltd.

Flavonoid compositions and related methods

Flavonoids that are isolated from plant material of the genus cecropia can be used to perturb g-protein coupled receptors in a mammalian cell. In some instances, one or more flavonoids may interact with one or more of the g-protein coupled receptors to transiently increase the concentration of cytosolic calcium.
Instituto De Investigaciones Cientificas Y Servicios De Alta Tecnologia (indicasat Aip)

Methods of therapeutic monitoring of nitrogen scavenging drugs

The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods that utilize this technique to adjust the dosage of a nitrogen scavenging drug, determine whether to administer a nitrogen scavenging drug, and treat nitrogen retention disorders.. .
Horizon Therapeutics, Llc

Leg-pressurizing device attachable/detachable to/from riding apparatus

The present invention relates to a leg-pressurizing device attachable to and detachable from a riding apparatus of the present invention, when a user is pedaling while sitting on a saddle, a pair of calf pressing rollers constantly pressurize lower surfaces of user's calves upward and downward and forward and backward while the user's calves move upward and downward and forward and backward, and a pair of tiptoe pressing rollers constantly pressurize user's tiptoes while the user's tiptoes are rotating, so that the user's calves and tiptoes are pressurized regularly by the rotational movement of the rollers, thereby enabling smooth blood circulation of the leg and preventing various adult diseases.. .

Vascular implant

Methods and devices relate to the use and construction of a vascular stent. A stent assembly includes mesh structure that is at least partially attached to a support or stent structure.
Silk Road Medical, Inc.

Baroreceptor testing prior to implantation methods and apparatus

Systems and methods for screening a subject for a therapy are described. A mechanical stimulation device positioned near at target location of a blood vessel to provide a mechanical stimulus to the blood vessel.
Vascular Dynamics, Inc.

Systems and methods for protecting the cerebral vasculature

Vascular filters and deflectors and methods for filtering bodily fluids. A blood filtering assembly can capture embolic material dislodged or generated during an endovascular procedure to inhibit or prevent the material from entering the cerebral vasculature.
Claret Medical, Inc.

Conical vein filter with improved balance

Disclosed herein is a removable vena cava filter for capturing thrombi in a blood vessel. The filter includes a plurality of primary struts having first ends attached together at their first ends.
Cook Medical Technologies Llc

Apparatus and use for treating blood vessels

An electrosurgical apparatus is provided. The electrosurgical apparatus includes a cannula insertable into a patient and positionable adjacent abnormal tissue.
Covidien Lp

Atherectomy devices and methods

Rotational atherectomy devices and systems can remove or reduce stenotic lesions in blood vessels by rotating one or more abrasive elements within the vessel. The abrasive elements can be attached to a distal portion of an elongate flexible drive shaft that extends from a handle assembly that includes a driver for rotating the drive shaft.
Cardio Flow, Inc.

Systems and methods for closing portions of body tissue

A system for closing a blood vessel includes a housing having a proximal end and a distal end and configured to be held in the hand of a user, an elongate body extending from the distal end of the housing, a distal housing having a proximal end coupled to a distal end of the elongate body and having a cavity including an opening on a side of the distal housing, a lumen passing through the elongate body and terminating at the cavity of the distal housing and configured to couple to a vacuum source, a sensor carried by the distal housing adjacent the cavity and configured for identifying a blood vessel, wherein the lumen is configured to maintain a vacuum within the cavity when a probe having a vessel closure module is inserted within the lumen and the vessel closure module is within the cavity.. .
Orpheus Ventures, Llc

Access closure configuration

A method may comprise creating a first passage across a wall with a sharpened member at a first angle relative to a lumen; advancing an anchor assembly through the first passage such that a distal portion of the anchor assembly is placed within the blood vessel; applying a force to the anchor assembly to position an adjacent portion of the blood vessel wall into a desired contact configuration relative to the anchor assembly; and while maintaining the desired contact configuration, advancing a needle through a portion of the anchor assembly and through a portion of the wall of the blood vessel to form an expandable tract between overlapping tissue portions of the vessel wall, wherein a portion of the anchor assembly comprises a saddle-shaped needle receiving structure configured to receive and support the needle after it has been advanced across the portion of the wall to create the expandable tract.. .
Arstasis, Inc.

Device and intravascular imaging and sensing

An intravascular sensor device can be used to guide treatment of a diseased blood vessel in the body of a patient. In some examples, the intravascular sensor device includes a pressure sensor and an ultrasound transducer.

Device and intravascular imaging and sensing

An intravascular sensor device can be used to guide treatment of a diseased blood vessel in the body of a patient. In some examples, the intravascular sensor device includes a pressure sensor and an ultrasound transducer.

Transcranial doppler-based displaying three-dimensional intracranial blood flow information

A transcranial doppler-based method for displaying 3d intracranial blood flow information and a system thereof, comprising: a. Performing multi-beam ultrasound scanning on predetermined intracranial areas using transcranial doppler ultrasound probe, receiving ultrasonic echo signals; b.
Shenzhen Delica Medical Equipment Co., Ltd.

Monitoring monitoring blood pressure of a subject

A monitoring apparatus for monitoring a blood pressure information of a subject is disclosed. The monitoring apparatus comprises an ultrasound transducer for emitting ultrasound waves to a volume of the subject that includes a blood vessel and for receiving ultrasound waves from said volume of the subject, and for providing a first signal on the basis of ultrasound waves received from the volume of the subject.
Koninklijke Philips N.v.

Vascular selection from images

Methods and systems for manually assisted definition of vascular features are described. In some embodiments, vascular centerlines identified by image analysis are divided into segments.
Cathworks Ltd.

Stent graft monitoring assembly and use thereof

Assemblies are provided for positioning within a lumen comprising a stent graft; and a sensor positioned on the stent graft. Within certain aspects the sensors are wireless sensors, and include for example one or more fluid pressure sensors, contact sensors, position sensors, pulse pressure sensors, blood volume sensors, blood flow sensors, chemistry sensors (e.g., for blood and/or other fluids), metabolic sensors (e.g., for blood and/or other fluids), mechanical stress sensors and/or temperature sensors..
Canary Medical Inc.

System and detecting a health condition using an optical sensor

A biosensor includes an optical sensor circuit that emits light directed at skin tissue of a patient at a plurality of wavelengths. A first and second spectral response of light reflected from the tissue is obtained around a first wavelength in a uv range and a second wavelength in an ir range.
Sanmina Corporation

Blood collection safety devices and methods of use and manufacture

An automatically locking safety device, e.g., for use in a blood collection procedure, can include a housing, first and second needle covers that are at least partly received in the housing, and a needle that is at least partly received in at least one of the first and second needle covers. The needle can include a proximal tip configured for placement into a patient and a distal tip configured for placement into a blood collection vial.
Sta-med, Llc

Wearable oximeter for respiration measurement and compensation

Systems, devices, and methods for measuring one or more parameters at a tissue site of a patient are disclosed. The system can include a sensor that can be configured to measure a first physiological parameter.
Nonin Medical, Inc.

Methods, devices, and systems for physiological parameter analysis

Methods, devices, and systems may use a kinetic model to determine physiological parameters related to the kinetics of red blood cell glycation, elimination, and generation. Such physiological parameters can be used, for example, to determine a more reliable calculated hba1c.
Abbott Diabetes Care Inc.

Photoplethysmographic wearable blood pressure monitoring system and methods

A photoplethysmographic (“ppg”) device having a housing, a band and a first optical sensor. The band extends from the housing and is configured to enclose an attachment site on a user's body.
Sensogram Technologies, Inc.

Non-invasive blood pressure monitoring device and method

The present disclosure relates to a device and a method for blood pressure measurement, the device (12) comprising a pressurizing unit (30), that is arranged to supply, via at least one supply line (32), a wearable cuff (14) which is arranged to pressurize a measurement site (16) of a subject of interest, a pressure detection unit (40) that detects a cuff pressure (p2) in a direct or mediate fashion, a control section (50) comprising a feed forward 5 controller (64) arranged to output a target inflation flow signal based on a desired inflation rate (or pressure), a feedback controller (62) arranged to minimize the error between a target inflation rate (or pressure) and an actual inflation rate (or pressure), wherein the output of the feed forward controller (64) and the output of the feedback controller (62) are combined to drive the pressurizing unit (30), and a blood pressure determination unit (100) arranged to calculate a blood pressure value based on the cuff pressure (p2) detected by the pressure detection unit (40) during inflation when the cuff pressure (p2) is increased by the pressurizing unit (30) in accordance with a defined pressurizing regime.. .
Koninklijke Philips N.v.

Method and system for cuffless blood pressure estimation using photoplethysmogram features and pulse transit time

A method and system for blood pressure (bp) estimation of a person is provided. The system is estimating pulse transit time (ptt) using the ecg signal and ppg signal of the person.
Tata Consultancy Services Limited

Methods of identifying and locating tissue abnormalities in a biological tissue

A method of identifying and locating tissue abnormalities in a biological tissue includes irradiating an electromagnetic signal, via a probe defining a transmitting probe, in the vicinity of a biological tissue. The irradiated electromagnetic signal is received at a probe, defining a receiving probe, after the signal is scattered/reflected by the biological tissue.
Emtensor Gmbh

Hybrid one- and two-sided flow-encoding only (hotfeo) for velocity-encoding phase contrast mri

A phase-contrast mri (pc-mri) system and method employing a hybrid one- and two-sided flow encoding only (hotfeo) acquisition scheme for accurate blood flow and velocity measurements of three-directional-velocity-encoding pc-mri.. .
The Regents Of The University Of California

Methods of determining tissue viability

A method of performing a surgical procedure includes generating an infrared image of tissue using a thermographic camera, analyzing the infrared images to determine blood flow characteristics of the tissue, and resecting a portion of the tissue determined to have abnormal blood flow characteristics.. .
Covidien Lp

Systems and methods for estimating ischemia and blood flow characteristics from vessel geometry and physiology

Systems and methods are disclosed for determining individual-specific blood flow characteristics. One method includes acquiring, for each of a plurality of individuals, individual-specific anatomic data and blood flow characteristics of at least part of the individual's vascular system; executing a machine learning algorithm on the individual-specific anatomic data and blood flow characteristics for each of the plurality of individuals; relating, based on the executed machine learning algorithm, each individual's individual-specific anatomic data to functional estimates of blood flow characteristics; acquiring, for an individual and individual-specific anatomic data of at least part of the individual's vascular system; and for at least one point in the individual's individual-specific anatomic data, determining a blood flow characteristic of the individual, using relations from the step of relating individual-specific anatomic data to functional estimates of blood flow characteristics..
Heartflow, Inc.

Transferrin receptor transgenic models

In some aspects, the present invention provides chimeric transferrin receptor (tfr) polynucleotides and polypeptides. In other aspects, this invention provides chimeric tfr transgenic animal models and methods of using the animal models to identify therapeutics that can cross the blood-brain barrier..
Denali Therapeutics Inc.

Canon Kabushiki Kaisha

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Human Link Co., Ltd.

. .

. .

Self-charging implantable power source with biosensor functionality

An analyte-based self-charging implantable power source that can also exhibit biosensor functionality is provided that utilizes a biofuel cell in combination with amplifying circuitry. The power source utilizes a biofuel cell and supplies relatively high power at useful voltages by converting the chemical energy stored in an analyte, such as glucose, which is a renewable energy source within the body, utilizes safe bio-based materials that pose no harm to the human body, and has the added benefit of being capable of sensing the levels of the analyte used for the biofuel cell (for example, blood glucose levels if blood glucose is used as the biofuel) at the same time, while retaining the volumetric energy density of the system..

Insulin pump having basal rate testing features

Methods of establishing an insulin delivery rate in a pump and an insulin pump are disclosed. A method includes selecting a set of alerts from one or more sets of alerts.
Tandem Diabetes Care, Inc.

Systems and methods for providing a stem cell bank

Methods, computer systems, and computer program products for maintaining a stem cell registry comprising information about a plurality of stem cell units. A donor is enrolled in the stem cell registry.
Celularity, Inc.

Systems and methods of forming enhanced medical images

Systems and methods of producing medical images of a subject are disclosed herein. In one embodiment, structural data and vascular data are acquired from a region of interest in the subject.
University Of Washington

Dosimeters including lensless imaging systems

Among other things, a method comprises imaging a sample displaced between a sensor surface and a surface of a microscopy sample chamber to produce an image of at least a part of the sample. The image is produced using lensless optical microscopy, and the sample contains at least blood from a subject.
Alentic Microscience Inc.

Methods and probes for determining the concentration of copper

The present invention relates to new probes and methods for determining the concentration of copper. In particular the present invention refers to a method for determining the concentration of “free” copper in a serum or blood sample with a high degree of sensitivity and accuracy..
Igea Research Corporation

Systems and methods to determine the age of cells

Systems and methods are provided for determining the age of cellular hemoglobin in individual red blood cells in a blood sample by determining the percentage of hba1c. In embodiments, a method includes measuring side scatter and fluorescence of the individual red blood cells and identifying immature red blood cells and mature red blood cells from the side scatter and fluorescence measurement.
Beckman Coulter, Inc.

Method for determining a concentration of epithelial cells in a blood sample or aspirate sample

The invention relates to a method for determining a concentration of epithelial cells in a blood sample or aspirate sample originating from a human being or mammal and mixed with anti-clotting agent. Here, following the addition of antibodies, antibody fragments, or antibody mimetica, which are each aimed against an antigen that is specific to epithelial cells, the sample is incubated until a decreasing binding rate of the binding of the antibodies, antibody fragments, or antibody mimetica to the cells is achieved.

Method for calculating hematocrit in blood, calibrating biochemical index value in blood, and system thereof

A method for calculating hematocrit in blood includes: applying a blood sample to a reagent layer on an electrochemical test strip; sequentially applying a first high positive voltage and a second high positive voltage to the blood sample, in which the second high positive voltage is greater than the first high positive voltage, and the first high positive voltage is greater than or equal to 1.0 v; calculating a quantity of electricity corresponding to the period of applying the second high positive voltage; and calculating a hematocrit of the blood sample according to the quantity of electricity.. .
Delbio, Inc.

Reducing centrifugal pump bearing wear through dynamic magnetic coupling

A pump drive for an extracorporeal blood pumping system including an adjustable drive magnet. The pump drive may be coupled to a blood pump which includes a pump impeller.
Medtronic, Inc.

Method for diagnosing, quantifying, treating, monitoring or evaluating conditions, diseases or disorders associated with human papilloma virus (hpv) infection

A method of diagnosing, quantifying, treating, monitoring or evaluating a condition in a subject is provided. The method comprises obtaining a sample from the subject, detecting and determining the presence or quantity of one or more than one human papilloma virus (hpv) in the sample, wherein the presence or quantity of the one or more than one hpv is indicative of the presence of the condition in the subject or an increased likelihood of the subject for developing the condition when compared to a control.

Methods for measuring enzyme activity useful in determining cell viability in non-purified samples

Methods for detecting microorganisms, in particular detection of bacteria and methods for measuring enzyme activity, such as deoxyribonucleic acid (dna) polymerase activity are disclosed. The aforesaid methods include, but are not limited to such methods performed on microbial crude lysates, useful for determining microbial enzyme activities, which can be linked to amplification signal generators such as real-time polymerase chain reaction (pcr) techniques, thereby enabling determination of microbial pathogens in samples such as unpurified blood and other body fluids.
Momentum Bioscience, Ltd.

Cell-free methylated and unmethylated dna in diseases resulting from abnormalities in blood glucose levels

Disclosed herein are compositions and methods for determining new-onset type 1 diabetes, methylation-specific polymerase chain reaction assays for determining new-onset type 1 diabetes, methods for distinguishing between type 1 diabetes and type 2 diabetes, methods for dysglycemia in obese adolescent subjects including obese adolescent subjects having type 2 diabetes and methylation-specific polymerase chain reaction assays for determining dysglycemia in obese adolescent subjects including obese adolescent subjects having type 2 diabetes.. .
Universite Libre De Bruxelles

Compositions and methods for modulating an immune response

The invention provides methods of modulating follicular regulatory t (tfr) cell-mediated immune responses, follicular helper t (tfh) cell-mediated immune responses or both, and the use of those methods in the treatment of diseases or conditions mediated by tfr or tfh cells. The invention also provides novel methods for identifying tfr and tfh cells in a population of cells.
President And Fellows Of Harvard College

Fusogenic properties of saposin c and related proteins and peptides for application to transmembrane drug delivery systems

The present invention comprises a method for delivering pharmaceutical and/or imaging agents within and/or through the dermal, mucosal and other cellular membranes, and across the blood-brain barrier, utilizing a fusogenic protein. The fusogenic protein is associated with a phospholipid membrane, such as a liposome.
Children's Hospital Medical Center

Carboxy substituted (hetero) aromatic ring derivatives and preparation method and uses thereof

Carboxy-substituted (hetero)aryl derivatives, pharmaceutical compositions comprising these compounds, and methods of preparing such compounds and compositions are provided. The compounds or compositions are useful in inhibiting xanthine oxidase and urate anion transporter 1, and also can be used in the treatment or prevention of diseases associated with high blood uric acid level in mammals, especially humans..
Sunshine Lake Pharma Co., Ltd.

Wireless midfield systems and methods

Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters.
The Board Of Trustees Of The Leland Stanford Junior University

Optimizing neuromodulation stimulation parameters using blood parameter sensing

The present disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Particularly, aspects of the present invention are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters..
Verily Life Sciences Llc

Medical fluid drainage system

A medical fluid drainage system which may be advantageously used to actively absorb excess fluid from an interstitium in a living host and to transport it from an inlet member 1 in a non edematous body part out of an outlet member 4 via pumps (5, 6, 7) built in series, such as a distal area with functional lymphatic vessels, or directly in a lymphatic vessel, or directly in a blood vessel.. .
Ecole Polytechnique Federale De Lausanne (epfl)

Seeping flow anti-clotting blood catheter

A catheter includes an elongated tube having a distal end and a proximal end. The elongated tube includes porous material having an interior and an exterior face.
The Charles Stark Draper Laboratory, Inc.

Seeping flow anti-clotting blood catheter

A multi-lumen catheter includes a primary lumen having a proximal end and a tip and a secondary lumen parallel to the primary lumen. The primary lumen and the secondary lumen share a wall.
The Charles Stark Draper Laboratory, Inc.

Blood purification apparatus

The present teachings relate to a blood purification apparatus in which the connection of a substitution line to a collecting port can be checked accurately and instantly and even during blood purification treatment. A blood purification apparatus includes a blood circuit, a dialyzer, a dialysate introduction line, a dialysate drain line, a substitution line one end of which is connected to a collecting port provided at a predetermined position of the dialysate introduction line and an other end of which is connected to the blood circuit, a substitution pump configured to form a pressure-increasing portion that includes the collecting port, and a pressure-measuring device capable of measuring a pressure in the pressure-increasing portion.
Nikkiso Company Limited

Va ecmo with pulmonary artery ventilation

A veno-arterial extracorporeal membrane oxygenation system includes a dual lumen drainage cannula configured for withdrawing blood from a patient's vasculature in a manner that provides a perfusion of oxygenated blood with reduced carbon dioxide content while unloading the left ventricle, with two points of access to the patient's vasculature. The dual lumen drainage cannula has a first drainage tube and a second drainage tube co-axially aligned with the first drainage tube.
Cardiac Assist, Inc.

Wire scaffold device for ventricular assist device

A ventricular assist system includes a ventricular assist device (“vad”) and an expandable stent. The vad may include a pump and an inlet element defining an inlet opening communicating with the pump, the inlet element being adapted for positioning with the inlet opening disposed within a ventricle of a heart when the system is in an operative condition.
Heartware, Inc.

Apparatus and methods for optimizing intra cardiac filling pressures, heart rate, and cardiac output

Apparatus, systems, and methods are provided for optimizing intracardiac filling pressures and cardiac output in patients with heart failure, conduction disease, and atrial fibrillation. The system is able to adjust and optimize intracardiac filling pressures and cardiac output by adjusting heart rate and the effective amount of total body blood volume.
Cardioflow Technologies, Llc

Blood pump

A blood pump comprises a pump casing having a blood flow inlet and a blood flow outlet, and an impeller arranged in said pump casing and rotatably supported in the pump casing by a bearing so as to be rotatable about an axis of rotation. The impeller has blades for conveying blood from the blood flow inlet to the blood flow outlet.
Abiomed Europe Gmbh

Membrane catheter

A substance exchange device for intracorporeal use includes a cavity for receiving blood having at least one blood inlet and at least one blood outlet, a substance exchange membrane adjoining the cavity, a supply duct for supplying an exchange fluid to the substance exchange membrane, a blood pump arranged within the cavity and a drive unit for the blood pump. The blood pump is configured to pump blood in a direction from a blood inlet to a blood outlet of the cavity.
Technische UniversitÄt Wien

Clay-based hemostatic agents

A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting.
Z-medica, Llc

Fluorescent compounds for imaging of blood vessels and blood flow, and an in vivo screen for pro- and anti-angiogenic agents

The present invention discloses fluorescent compounds and a method for their use for selective imaging of blood vessels and blood flow. By applying these fluorescent compounds and the imaging process to a zebrafish model, the present invention further provides methods and procedures for the discovery, selection, and characterization of pro- and anti-angiogenic agents..
Colossus Biopharma Consultants Co., Ltd.

Methods for the mobilization and use of t-cells with enhanced reconstitution potential and life-span

The disclosure provides a new source of peripheral blood naive/memory stem cells (i.e. (tn)/tscm/tcm) t-cells with enhanced reconstitution potential and/or longer life spans.
Glycomimetics, Inc.

Treatment of steroid-induced hyperglycemia with fibroblast growth factor (fgf) 1 analogs

Methods of using fgf1 analogs, such as fgf1 mutant proteins having an n-terminal deletion, point mutation(s), or combinations thereof, to reduce blood glucose levels in subjects with steroid-induced diabetes, hypercortisolemia, or diabetes due to treatment with an antipsychotic agent, are provided. Such mutant fgf1 proteins can be part of a chimeric protein that includes a β-klotho-binding protein, an fgfr1-binding protein, a β-klotho-binding protein and a fgfr1-binding protein, a c-terminal region from fgf19 or fgf21..
Salk Institute For Biological Studies

Device and treating conditions associated with neuroinflammation

Disclosed is a device and method for treating a neurodegenerative disease or condition associated with neuroinflammation induced by a leukotriene. The device is a film unit dosage form having a film layer and a safe and effective amount of a leukotriene receptor antagonist or leukotriene synthesis inhibitor.
Intelgenx Corp.

Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the gi tract. Many embodiments provide a swallowable device for delivering the agents.
Rani Therapeutics, Llc

Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems and methods

Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel.
Medtronic Ardian Luxembourg S.a.r.l.

Method of confirming safe delivery pathway to patient prior to energy delivery

Systems and methods to confirm safe delivery of treatment energy to a patient by identifying a presence of a fault in an energy delivery pathway and identifying a location of the fault within the device. The system includes a processing unit configured to calculate blood impedances external to the device based on known impedance characteristics of the device, and then to calculate impedances within the device during energy delivery based on the calculated blood impedances.
Medtronic, Inc.

Methods for restoring blood flow within blocked vasculature

The devices and methods described herein relate to clearing of blockages within body lumens, such as the vasculature, by addressing the frictional resistance on the obstruction prior to attempting to translate and/or mobilize the obstruction within the body lumen.. .
Covidien Lp

Tourniquet

A tourniquet with two locking, two release and two tension mechanisms that occludes blood flow in extremities, but can also be used as a pressure strap to hold gauze over wounds on different part of the body including torso.. .

Vascular closure with shape memory characteristic

Among other things, there is disclosed devices for closing an internal opening, e.g. A hole in a blood vessel, that includes a shape memory function.
Cook Medical Technologies Llc

Quantitative phantomless calibration of computed tomography scans

An apparatus, method, and computer program product for calibrating a ct scan without the use of an external calibration phantom, to enable quantitative assessment of internal body tissues and organs and additionally for any application that would benefit from a calibration of the scan attenuation data, such as viewing ct images in a consistent fashion. Embodiments are described with applications to quantitative assessment of bone density in the spine and hip, mineral content in blood vessels, hepatic-fat content in the liver, and gray-to-white matter ratio in the brain.
O.n.diagnostics, Llc

Vehicle operating element and noninvasively measuring biomolecules

The invention relates to a vehicle operating element (12) comprising a sensor (14) for non-invasive measurement of biomolecules in the blood of an operator of a vehicle operating element (12) by means of electrochemical impedance spectroscopy, comprising at least one antenna (16) which includes at least a first conductive layer, a second conductive layer and an insulating layer being sandwiched between the two conductive layers. By means of the second conductive layer an excitation signal can be coupled out and an off-resonance excitation signal can be coupled into the antenna (16).
Trw Automotive Gmbh

Wearable physiological monitoring systems and methods

A physiological monitoring system can use physiological wearable monitors to collect and/or detect various parameters, such as cough, wheeze, heart rate, skin temperature, activity, respiration rate, skin impedance, electro-cardiogram data, blood pressure, galvanic skin response, and the like. One or more of these parameters, or other such parameters, may be used in methods in the fields of lung cancer, physiotherapy, monitoring disabled or challenged individuals, monitoring end of life conditions, monitoring breathing gas usage, monitoring patients and individual wellness, data acquisition, athletic sports monitoring, athletic sports entertainment, virtual reality feedback, telemedicine, hospital aid, illness detection and its severity, and public service, as examples.
Health Care Originals, Inc.

Portable noninvasively measuring blood glucose level and operating method thereof

Disclosed is an operating method of a portable apparatus for noninvasively measuring blood glucose levels, and the method comprising (a) measuring a first signal value according to ambient environmental light and temperature by using at least one light receiving elements when an led which emits light with wavelengths to be absorbed into or scattered by glucose is switched off; (b) measuring a second signal value according to incident light which is scattered by or transmitted through subject tissue and enters the photodetecting unit when the led is switched on; (c) calculating a glucose concentration measurement of a subject by using the first signal value and the second signal value; and (d) wherein the quantity of light detected by the photodetecting unit is adjusted by feeding the difference between the glucose concentration measurement and a first reference value back to the photodetecting unit.. .

Methods, systems, and devices relating to open microfluidic channels

Various collection devices, systems and methods relating to the use of devices with open microfluidic channels disposed within a housing defining a lumen. These devices make use of microneedles passed through apertures to induce fluid flow into microfluidic channel networks for collection and analysis.
Tasso, Inc.

Apparatus for rapid collection of blood from livestock

An apparatus useful for the rapid collection of blood from a subject (e.g., a blood vessel, such as the vein, artery or capillary bed of a bovine subject) and dispensing the blood therefrom into a test or collection device. In general, the apparatus comprises: (a) a body having a chamber formed therein, said chamber having an inlet and outlet, with said chamber configured to draw blood therein; (b) a hollow barrel connected to said chamber outlet; (c) an ejector operatively associated with said barrel; (d) a hollow needle connected to said body, with said hollow needle in fluid communication with said chamber through said inlet, so that blood can be rapidly drawn into said chamber through said needle.
Advanced Animal Diagnostics, Inc.

Portable noninvasively measuring blood glucose level and operating method thereof

Provided is a method for measuring blood glucose levels of a subject with a portable apparatus for noninvasively measuring blood glucose levels including at least one light receiving element for detecting light by using different light integration times, including: (a) switching on an led for emitting light having wavelength absorbed in or scattered by glucose; (b) measuring a first signal value according to light which is reflected off the surface skin layer of the subject and enters in response to a first light integration time in the situation where the light is radiated; (c) adjusting a second light integration time for measuring light reflected off the inner skin layer of the subject based on the first signal value; (d) measuring a second signal value according to the light which is reflected off the inner skin layer of the subject and enters in response to the adjusted second light integration time; and (e) producing the blood glucose level of the subject by using a third signal value according to light which enters due to an ambient environment and the second signal value in the situation where the led is switched off.. .

Portable noninvasively measuring blood glucose level and operating method thereof

Disclosed in an embodiment is an operating method of portable apparatus for noninvasively measuring blood glucose levels. The method includes: (a) measuring a first signal value according to ambient environmental light when an led for measuring signals which emits light with wavelengths to be absorbed into or scattered by glucose is switched off; (b) measuring a second signal value according to light which is scattered by or transmitted through subject tissue and enters a photodetecting unit when the led for measuring signals is switched on; (c) calculating a glucose concentration measurement of a subject by using the first signal value and the second signal value; and (d) adjusting the quantity of the light radiated from the led for measuring signals by feeding the difference between the glucose concentration measurement and a pre-established first reference value back to the driving current for the led for measuring signals..

Method and the non-invasive measurement of pulse transit times (ptt)

A method for estimating blood pressure (bp) values comprises: measuring at a first ptt value, a second ptt value, and further ppt values using a method comprising measuring a first arterial pressure pulse arrival time (pat) and measuring a second pat value; calculating a ptt value from the difference between the first pat value and the second pat value; processing a sequence of electrical impedance tomography (eit) images to identify at least one region of interest (roi); and estimating at least one of the first and second pat value from the variation of impedance value determined from the at least one roi. The method allows for the non-invasive and continuous determination of the pb values by using a calibration factor..
Csem Centre Suisse D'electronique Et De Microtechnique Sa - Recherche Et DÉveloppement

Blood pressure measuring device, blood pressure measurement method and blood pressure measurement program

Provided are a blood pressure measuring device, a blood pressure measurement method and a blood pressure measurement program that allow calculating blood pressure properly even for ambulatory users. A blood pressure measuring device 1 is provided with: an electrocardiogram acquisition unit 11 that acquires an electrocardiogram of a user; a pulse wave acquisition unit 12 that acquires a pulse wave of the user; a first extraction unit 13 that extracts a heart rate on the basis of the electrocardiogram; a second extraction unit 14 that extracts a pulse wave velocity on the basis of the electrocardiogram and the pulse wave; a third extraction unit 15 that extracts one or a plurality of feature values pertaining to the pulse wave, on the basis of the pulse wave; and a calculation unit 16 that calculates blood pressure of the user from the heart rate, the pulse wave velocity and the one or plurality of feature values extracted for the user, by a learner 17 that has learned, by nonparametric regression analysis, a relationship between blood pressure of each of a plurality of subjects and a heart rate, a pulse wave velocity and one or a plurality of feature values pertaining to a pulse wave extracted for each of the plurality of subjects..
The University Of Tokyo

Method and apparatus of assessment of access flow in hemodialysis patients by video imaging processing

Systems and methods are provided for assessing patient blood flow using video image processing. According to one aspect, a method of analyzing at least one blood flow characteristic of a patient includes capturing a video including a plurality of frames of an arterio-venous (av) fistula on the patient; amplifying motion in the video to produce a motion-amplified video; determining a difference in intensity between consecutive frames in the motion-amplified video to produce a time-function of an amplitude of the optic flow representing movement in an area of interest on the patient; and determining the at least one blood flow characteristic of the patient based on the time-function..
Fresenius Medical Care Holdings, Inc.

Method for measuring blood pressure, and measuring blood pressure based on said method

A method of measuring blood pressure, including: sensing an atmospheric pressure, an applied pressure, and a blood pressure of a blood vessel delivered to a skin and outputting an electrical signal indicating a result of sensing the pressures; dividing the electrical signal into a divided electrical signal which includes a direct current (dc) signal and an alternating current (ac) signal; processing the divided electrical signal; calculating the applied pressure using the processed electrical signal; and calculating a blood pressure average using the calculated applied pressure and a swing value of the processed electrical signal.. .
Umedix Corporation Limited

Device for measuring blood pressure and using the same

A device for measuring blood measure measures variations in electrical charges on the body as a result of heart activity. A method using the same is also described.
Rooti Labs Limited

Absorbent binder composition

The present disclosure is directed towards an absorbent binder composition that includes a hydrophilic polymer which has the capability of post-application, moisture-induced cross-linking. The absorbent binder composition can include 1) a superabsorbent polymer material which can include at least 15 mass percent monoethylenically unsaturated polymer, such as carboxylic acid, sulphonic acid, or phosphoric acid, or salts thereof, and an acrylate or methacrylate ester that contains an alkoxysilane functionality and 2) a polyvalent metal cation having a valence of at least two.
Kimberly-clark Worldwide, Inc.

Apparatus and methods for taking blood glucose measurements and recommending insulin doses

The present disclosure related to an apparatus that may be used for taking blood glucose measurements and providing individualized insulin dose recommendations wherein the apparatus is easy to use and facilitates improved diabetes control in patients. Also disclosed are related methods..
Hygieia, Inc.

Insulin management

A method of administering insulin includes receiving blood glucose measurements of a patient at a data processing device from a glucometer. The blood glucose measurements are separated by a time interval.
Aseko, Inc.

Systems and methods to detect and display endovascular features

In part, the disclosure relates to method for identifying regions of interest in a blood vessel. The method includes the steps of: providing oct image data of the blood vessel; applying a plurality of different edge detection filters to the oct image data to generate a filter response for each edge detection filter; identifying in each edge detection filter response any response maxima; combining the response maxima for each edge detection filter response while maintaining the spatial relationship of the response maxima, to thereby create edge filtered oct data; and analyzing the edge filtered oct data to identify a region of interest, the region of interest defined as a local cluster of response maxima.
Lightlab Imaging, Inc.

Systems and methods for fast simulation and visualization of sparse fluids

Example embodiments of the present invention are directed to systems and methods for simulating sparse fluids and visualizing the results. An example embodiment involves simulating sparse fluids on a two-dimensional surface and using that simulation to visualize the results on a three dimensional surface.
Take-two Interactive Software, Inc.

Methods for diagnosing and treating alzheimers disease using g72 protein and slc7a11 mrna as biomarkers

A method for diagnosing alzheimer's disease (ad) includes: obtaining a blood sample from a human subject suspected of having ad; determining a g72 protein level in the blood sample; determining an slc7a11 mrna expression level in the blood sample; comparing the g72 protein level with a first predetermined standard; comparing the slc7a11 mrna expression level with a second predetermined standard; and diagnosing the human subject with ad when the g72 protein level is higher than the first predetermined standard and the slc7a11 mrna expression level is higher than the second predetermined standard. An effective amount of a pharmaceutical composition may be administered to the diagnosed human subject for treating ad..
Kaohsiung Chang Gung Memorial Hospital

Method for detecting abnormalities in hemoglobin

The method describes rapid screening of whole blood samples, pin prick and blood spot cards, subjected to maldi—tof mass spectrometry. The spectra is generated and compared to those from normal healthy controls.
Map Ip Holding Limited

Blood characteristic measurement

Examples herein provide a method. The method includes applying an electrical potential difference over a blood sample in a testing cassette of a microfluidic device, the cassette including a microfluidic channel through which the blood sample flows.
Hewlett-packard Development Company, L.p.

Characterization of molecules in nanofluidics

Methods are provided for detecting and quantitating molecules using fluidics. In preferred embodiments, the methods comprise analyzing blood to detect the presence of circulating dna or cells from a fetus or tumor..
Bionano Genomics, Inc.

Method for the induction and expansion of natural killer cells derived from peripheral blood mononuclear cells

The present invention relates to a method for inducing and expanding natural killer cells derived from peripheral blood mononuclear cells, which comprises co-culturing, as feeder cells, irradiated jurkat cells and irradiated epstein-barr virus transformed lymphocyte continuous line (ebv-lcl) cells in the presence of cytokines, along with peripheral blood mononuclear cells. According to the present invention, a large quantity of natural killer cells can be induced and proliferated from a small quantity of peripheral blood mononuclear cells even without the use of high-cost equipment or various kinds of expensive cytokines, thereby making it possible to significantly improve the efficiency and efficacy of the prevention and treatment of cancer using the natural killer cells..
Nkmax Co., Ltd.

Methods and compositions for modulation of blood-neural barrier

Methods and compositions for modulating blood-neural barrier (bnb) for the treatment of cns conditions such as edema, and for increased drug delivery efficacy across the bnb. The present invention further relates to improved tpa treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the pdgf signaling pathway.
University Of Maryland, Baltimore

Modulators of myocyte lipid accumulation and insulin resistance and methods of use thereof

Formulations and methods for reducing blood glucose and/or increasing insulin signaling in a subject have been developed. The formulations include sbi-477 and compounds based on sbi-477 i.e., sbi-477 analogs (collectively, sbi-477 compounds) and/or mondo family inhibitors, in an effective amount to inhibit intracellular lipid accumulation and/or increase cellular glucose uptake when compared to levels in a control subject not administered the composition.
Sanford Bumham Prebys Medical Discovery Imstitute

Acrylonitrile-based membrane with improved performance

The present disclosure relates to improved semipermeable membranes based on acrylonitrile copolymers for use in dialyzers for the extracorporeal treatment of blood in conjunction with hemodialysis, hemofiltration or hemodiafiltration. The present disclosure further relates to methods of producing such membranes..
Gambro Lundia Ab

Method and treating ascites

A valve for treating ascites, the valve comprising: a body having a distal end, a proximal end and a lumen extending therebetween; at least one valve element disposed in the lumen of the body, the at least one valve element being a one-way valve element configured to permit the passage of fluid in a single direction through the lumen of the body; and at least one connection element provided on at least one of the distal end and the proximal end of the body, wherein the at least one connection element is configured to connect the body of the valve to the side wall of a blood vessel.. .
Ewimed

Catheter assembly

A method involves puncturing a blood vessel of a patient with the sharp needle point of an inner needle, axially advancing a guide wire operating member connected to a guide wire to axially advance the guide wire relative to the inner needle to move the guide wire along the blood vessel, and axially advancing a catheter operating member connected to a catheter to axially advance the catheter in the distal direction relative to both the inner needle and the guide wire such that the distal end of the catheter is positioned at a target position in the blood vessel.. .
Terumo Kabushiki Kaisha

Cardiac, cardiopulmonary, and/or hemodynamic phenotyping

Various systems, apparatus and methods are described herein for generating cardiac, cardiopulmonary, and/or hemodynamics phenotypes of patients for use in various applications. In various embodiments, a ventilation support apparatus connected to a patient may be operated to perform a therapeutic maneuver selected to cause one or more targeted receptors of the patient to initiate an autoregulation response in the patient.
Koninklijke Philips N.v.

Vascular access device and guiding portion

According to various embodiments, a method and system to obtain access to a blood vessel underneath a skin layer that may preserve lifespan of the blood vessel and reduce executional skill variability may be provided. The method includes placing a guiding portion between the blood vessel and the skin layer; and configuring the guiding portion to receive and guide a needle to reach the same location of the blood vessel repeatedly and consistently; and forming a resultant scarred track between the blood vessel and the skin layer as the guiding portion is resorbed over time.
Agency For Science, Technology And Research

Apparatus for extracorporeal blood treatment with automatic monitoring of respiratory rate

An apparatus and method for extracorporeal blood treatment, especially a dialysis apparatus, are disclosed, the apparatus includes a radar sensor for monitoring a patient located at a place of treatment.. .
B. Braun Avitum Ag

Air separator including forced circulation

An air separator of an extracorporeal blood treatment machine is disclosed in which a flow conducting element is arranged directly downstream of a fluid inlet of an air separator opening into an air separating chamber, the fluid inlet forcing the inflowing fluid into a flow direction at least along/tangential to the chamber periphery.. .
B. Braun Avitum Ag

Air bubble removal from extracorporeal blood via chemical entrapment of nitrogen

A process includes removing air bubbles from extracorporeal blood via chemical entrapment of nitrogen (n2) gas.. .
International Business Machines Corporation

Blood purification apparatus

To provide a blood purification apparatus in which the hot-water-disinfection time can be optimized with consideration for environmental conditions. A blood purification apparatus provided with a dialyzer for giving dialysis treatment to a patient, and with a tube for introducing dialysate into or discharging drain liquid from the dialyzer.
Nikkiso Company Limited

In-line sensors for dialysis applications

A system for monitoring water quality for dialysis, dialysis fluids, and body fluids treated by dialysis fluids, is disclosed. The system uses microelectromechanical systems (mems) sensors for detecting impurities in input water or dialysis fluid, and in the prepared dialysate.
Baxter Healthcare S.a.

Impeller for axial flow pump

A rotor for an axial-flow blood pump has blades projecting outwardly from a hub and channels between the blades. The blades incorporate hydrodynamic bearing surfaces capable of suspending the rotor during operation.
Heartware, Inc.

Tissue-adhesive porous haemostatic product

A process of preparing an adhesive haemostatic product is provided. The process comprises: (a) coating a porous solid substrate with a coating liquid that comprises an electrophilically activated polyoxazoline (el-pox) and a solvent to produce a coated substrate; and (b) removing the solvent from the coated substrate.
Gatt Technologies B.v.

Immune motifs in products from domestic animals

The present invention provides a means to prepare a product from domestic animal milk, blood or eggs which comprises an array of t-cell exposed motifs similar in identity, distribution and concentration to those found in human immunoglobulin variable regions and to prepare and apply the product as an immune modulating agent for administration either as a nutritional supplement or as a pharmaceutical product.. .
Iogenetics, Llc

Use of elafin for disorders associated with elastase independent increase in troponin

The present invention relates to the use of elafin for the treatment and/or prevention of diseases or disorders associated with an increase in troponin levels, which are non elastase dependent. The present invention in a preferred embodiment relates to a method and composition, using elafin, for protecting the heart muscle or other muscles from damage induced by abnormal blood flow and/or inflammation, which may result from, for example, a heart infarction.
Proteo Biotech Ag

Thioredoxin, thioredoxin peptides or derivatives for treatment of age-related hypertension

The incidence of high blood pressure is strikingly high with advancing age, and is an independent prognostic factor for the onset or progression of a variety of cardiovascular disorders (cvd). There is a critical need for a curative therapy against age-related hypertension.
Board Of Regents, The University Of Texas System

Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device

Embodiment of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the gi tract. Many embodiments provide a swallowable device for delivering the agents.
Rani Therapeutics, Llc

Long acting liraglutide compositions

The present invention relates to a composition comprising particles, wherein said particles comprise poly(lactide-co-glycolide) polymer, therapeutically effective amount of liraglutide or a pharmaceutically acceptable salt thereof and a hydrophilic particle size modulating agent, wherein, the composition is free of added divalent metal ions. The composition provides effective blood glucose control for about 7 days when administered as once a week formulation to a period of about 30 days after single administration of a monthly dose to a patient in need thereof..
Sun Pharma Advanced Research Company Limited

Methods of therapeutic monitoring of nitrogen scavenging drugs

The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods that utilize this technique to adjust the dosage of a nitrogen scavenging drug, determine whether to administer a nitrogen scavenging drug, and treat nitrogen retention disorders.. .
Horizon Therapeutics, Llc

Methods of therapeutic monitoring of nitrogen scavenging drugs

The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods that utilize this technique to adjust the dosage of a nitrogen scavenging drug, determine whether to administer a nitrogen scavenging drug, and treat nitrogen retention disorders.. .
Horizon Therapeutics, Llc

Methods of therapeutic monitoring of nitrogen scavenging drugs

The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods that utilize this technique to adjust the dosage of a nitrogen scavenging drug, determine whether to administer a nitrogen scavenging drug, and treat nitrogen retention disorders.. .
Horizon Therapeutics, Llc

Methods of therapeutic monitoring of nitrogen scavenging drugs

The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods that utilize this technique to adjust the dosage of a nitrogen scavenging drug, determine whether to administer a nitrogen scavenging drug, and treat nitrogen retention disorders.. .
Horizon Therapeutics, Llc

Methods for delivering insulin preparations into a lumen of the intestinal tract using a swallowable drug delivery device

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the gi tract. Many embodiments provide a swallowable device for delivering the agents.
Rani Therapeutics, Llc

Trilayer coated blood collection tube with low oxygen transmission rate

An article is described including an article surface and a coating set comprising an optional tie coating or layer, a barrier coating or layer, and a ph protective layer. The respective coatings or layers can be applied by chemical vapor deposition of a polysiloxane or polysilazane precursor in the presence of oxygen.

Apparatus increasing rate of blood flow

An apparatus includes a thermal guide element to contact a specific site of a subject to apply a thermal stimulus from the thermal guide element to the specific site; an electrical thermal stimulus controller to raise a temperature of the thermal guide element; and a laser doppler tissue blood flow meter attached to the subject. The electrical thermal stimulus controller raises a peak temperature of the thermal guide element to be 50±5° c.

Penis enhancement system

A penis enhancement system. The penis enhancement system includes a first and second ring, each having a bead affixed thereto.

Stent

The invention relates to a stent for transluminal implantation in hollow organs, in particular in blood vessels, ureters, esophagi, colons, duodena, or bile ducts, comprising a substantially tubular body, which can be transferred from a compressed state having a first cross-sectional diameter into an expanded state having an enlarged second cross-sectional diameter, wherein the stent comprises a plurality of cells, which are defined by bordering elements formed by the tubular body. The stent is distinguished in that some of the cells are extended in the longitudinal direction of the stent in comparison with the remaining cells in order to form a slanted end face of the stent..
Medfirst Ag

Artificial blood vessel, producing artificial blood vessel, and producing porous tissue regeneration substrate

The present invention aims to provide a method for producing a porous tissue regeneration substrate that allows a wide choice of solvents and easy adjustment of the bulk density and pore size of the porous substrate. The present invention also aims to provide a method for producing an artificial blood vessel and an artificial blood vessel.
Gunze Limited

Percutaneous to treat dissections

Some embodiments are directed to methods and systems for percutaneously treating dissections in a patient's vasculature, such as, without limitation, the aorta. The method can include deploying a catheter containing a collapsed anchoring element, frame, and cover through a first vessel to an entry point of the dissection.
Endologix, Inc.

Nerve probe

Systems and methods provide interface to a patient's autonomic nerves via an interior lumen wall of a blood vessel. Systems can include a probe having at least one electrode for receiving electrical signals from the interior of the lumen wall.
Neuromedic, Inc.

Anti-fouling cannulas for endoscopic ports

A cannula incorporating a blood wicking/diversion mechanism to absorb and/or obstruct blood from running down the cannula onto an endoscope inserted therein, and/or the procedure site, thereby obfuscating the field-of-view during a thoracic procedure. In an embodiment the device comprises an elongate woven fabric wick contained within an open-faced lumen molded into the bottom wall of the cannula tubular body and running along its length to absorb blood or fluid running down its length.

Detection of fluidic current generated by rotating magnetic particles

Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one embodiment, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources.
Pulse Therapeutics, Inc.

System and treating heart tissue

Some embodiments of a system or method for treating heart tissue can include a control system and catheter device operated in a manner to intermittently occlude a heart vessel for controlled periods of time that provide redistribution of blood flow. In particular embodiments, the system can be configured to provide an estimation of the cumulative effects of the treatment.
Miracor Medical Sa

Blood vessel connectors and methods for blood vessel connection

Various embodiments of the present disclosure include an apparatus comprising a clip which includes a first side including a first ring configured to pass over an end of a first vessel, the first ring configured to engage the first side with the first vessel, and a second side coupled to the first side, the second side including a second ring configured to pass over an end of a second vessel, the second ring being configured to engage the second side with the second vessel. The first and second sides, when in a closed position, are configured to maintain the first and second vessels in substantially end-to-end contact..
Amt Medical B.v.

System and accelerated clutter filtering in ultrasound blood flow imaging using randomized ultrasound data

Described here are systems and methods for ultrasound clutter filtering to produce images of blood flow in a subject. In general, the clutter filtering is based on a singular value implementation, such as an accelerated singular value decomposition (“svd”).
Mayo Foundation For Medical Education And Research

Method of detecting vascular condition based on point fluctuation conduction characteristics of the heart and device utilizing the same

A method of detecting the vascular condition based on point fluctuation conduction characteristics of the heart and a device utilizing the same are disclosed in this patent. The method comprises: attaching flexible detection terminals firmly against the external skin adjacent to the heart or vascular walls; discretizing the detection area of the heart muscle or vascular walls into a plurality of preset detection points; through active emission of ultrasonic waves and continuous array reception of ultrasonic echoes carrying out multidimensional inversion of point fluctuations/point pulse waves using backend inversion; taking the multiple point fluctuations of the heart muscle as the multiple input signals of the vascular system and the multiple point pulse waves of a certain detection location of the blood vessel as the multiple output signals of the vascular system; identifying the vascular conduction characteristics by using digital signal processing methods; obtaining the conduction characteristics of a certain section of the blood vessel by decomposing the vascular conduction characteristics at different locations based on the cascade feature of the blood vessel; through feature extraction and feature comparison realizing the prediction and diagnosis of the vascular condition and the corresponding symptoms.
Guangzhou Phonpad Information Technology Cooperation Limited

Measurement of oxygen saturation of blood haemoglobin

There is provided a chest-based oximeter for measuring oxygen saturation of hemoglobin in blood of the chest of a subject, including at least one radiation source adapted to emit radiation onto the chest, at least one radiation detector adapted to detect radiation reflected from the chest, and a pressure device adapted to apply pressure to the oximeter to connect the oximeter to the chest.. .
Intelesens Ltd.

Algorithms for diabetes exercise therapy

Safe and effective exercise poses a specific set of challenges for subjects diagnosed with diabetes. These challenges include the coordination of exercise with blood glucose monitoring and insulin administration.
Fitscript Llc

Apparatus for rapid collection of blood from liverstock

An apparatus useful for the rapid collection of blood from a subject (e.g., the vein of a bovine subject) and dispensing the blood therefrom into a collection device includes: (a) a capillary body having a capillary chamber formed therein, with the chamber having an inlet and outlet, and with said chamber configured to draw blood therein through the inlet by capillary action; (b) a hollow barrel connected to the chamber outlet; (c) a plunger positioned in the barrel; and (d) a hollow needle connected to the capillary body, with the hollow needle in fluid communication with the capillary chamber through the capillary inlet, so that blood can be rapidly drawn into the capillary chamber through the needle by the combined action of vein pressure (or other pressure, if present, such as arterial pressure) and capillary action.. .
Advanced Animal Diagnostics, Inc.

Blood collecting device

A blood collecting device collects blood in a short time after puncture without scattering the blood into the open air other than a container for collecting the blood. One of representative blood collecting devices has a container unit that includes a screw portion, a holder that holds the container unit serving as a system whose one end is closed, a puncture unit that can be attached to the container or the holder, a through-hole of the puncture unit, and a puncture unit protection member that protects the puncture unit and the container unit..
Hitachi High- Technologies Corporation

Glucose control system with automatic adaptation of glucose target

A glucose control system employs adaptation of a glucose target (set-point) control variable in controlling delivery of insulin to a subject to maintain euglycemia. The glucose target adapts based on trends in actual glucose level (e.g., measured blood glucose in the subject), and/or computed doses of a counter-regulatory agent such as glucagon.
The General Hospital Corporation

Implantable oximetric measurement apparatus and use

Embodiments provide an apparatus, system, kit and method for in vivo measurement of blood oxygen saturation (bas). One embodiment provides an implantable apparatus for measuring bas comprising a housing, emitter, detector, processor and power source.
Incube Labs, Llc

Drug elution for in vivo protection of bio-sensing analytes

A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more therapeutic agents.
Senseonics, Incorporated

Blood pressure measuring apparatus

A pressurizing/depressurizing section (3) increases or decreases an internal pressure of a cuff (20). A first controlling section (4) controls an operation of the pressurizing/depressurizing section (3) so as to cause the internal pressure to transit from a pressure transient state to a pressure steady state and vice versa.
Nihon Kohden Corporation

Method for evaluating blush in myocardial tissue

Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (roi) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the roi.
Novadaq Technologies Ulc

Method for giving a prompt before blood pressure monitoring and corresponding ambulatory blood pressure monitor

A method is disclosed for notifying a patient before blood pressure monitoring. Also provided is a dynamic blood pressure monitor, which is used for notifying a patient before commencement of a blood pressure measurement..
Xi'an Shen Mindray Medical Electronics Research Institute Co., Ltd.

Systems and methods for evaluating blood circulation and early detection of cardiovascular issues

Systems and methods are provided for blood circulation evaluation by providing a measurement device collection in communication with a thermal exchange device comprising an appendage chamber having a thermal exchange member. The measurement device collection may measure patient information such as height, weight, temperature, pulse, and/or blood pressure, and transmit the patient information to the thermal exchange device to estimate patient blood volume based on the patient information.
Avacen Medical, Inc.

Assessment of microvascular dysfunction with spectral imaging

A method for quantifying microvascular function in a patient includes stabilizing a test portion of the patent to analyze. A microvascular blood flow parameter is measured using a first spectral imaging technique.
University Of Rochester

Sleeping support assembly

A sleeping support assembly for reposing in a prone position includes a first cushion that is configured to support a torso of a user. A second cushion is coupled to and extends from a first end of the first cushion.

Fujifilm Corporation

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Fujifilm Corporation

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Quantification of blood loss on the basis of computed tomography with a directly converting detector

A system and a method are for quantifying blood loss on the basis of contrast-agent based computed tomography imaging of the torso of a patient. To this end, image data of a computed tomograph is firstly read in, in order thereupon to apply an image analysis method for automatically detecting accumulations of blood.
Siemens Healthcare Gmbh

Pen-type medical fluorescent imaging device and system for aligning multiple fluorescent images using the same

The present invention relates to a pen-type medical fluorescent imaging device comprising: a probe which is elongated in the longitudinal direction and has an image capture unit at one end; a plurality of light source units surrounding the image capture unit; and a control unit for controlling the light source units, wherein the light source units comprise: a first light source for emitting light of a first wavelength range so that a blood vessel is marked by a first fluorescent material; and a second light source for emitting light of a second wavelength range so that a glioma is marked by a second fluorescent material, wherein the first and second light sources are selectively controlled by the control unit.. .
National Cancer Center

Automated segmentation utilizing fully convolutional networks

Systems and methods for automated segmentation of anatomical structures (e.g., heart). Convolutional neural networks (cnns) may be employed to autonomously segment parts of an anatomical structure represented by image data, such as 3d mri data.
Arterys Inc.

Image processing apparatus, endoscope system, and image processing method

An image processing apparatus includes an image acquisition unit that acquires an endoscope image, a blood vessel extraction unit that extracts a blood vessel having a specific thickness from the endoscope image, a blood vessel information calculation unit that calculates a plurality of pieces of blood vessel information regarding the blood vessel extracted by the blood vessel extraction unit, and a blood vessel parameter calculation unit that calculates a blood vessel parameter, which is relevant to the blood vessel having the specific thickness, by calculation using the blood vessel information.. .

Automated segmentation utilizing fully convolutional networks

Systems and methods for automated segmentation of anatomical structures (e.g., heart). Convolutional neural networks (cnns) may be employed to autonomously segment parts of an anatomical structure represented by image data, such as 3d mri data.
Arterys Inc.

Erythropoietic stimulating agent (esa) dosage determination

An erythropoietic stimulating agent (esa) dosing system/method determines patient-specific esa therapies for patients affected by insufficient hemoglobin production that may benefit from esa treatment. The esa dosing system includes a model that represents a process by which red blood cells are produced in humans.
Mayo Foundation For Medical Education And Research

Method for determining blood specimen

Disclosed is a method for determining a blood specimen, comprising preparing a first measurement sample by mixing a blood specimen of a subject with a first coagulation time measurement reagent and measuring first coagulation time, preparing a second measurement sample by mixing the blood specimen with a second coagulation time measurement reagent and measuring second coagulation time, and acquiring a value based on the first coagulation time and the second coagulation time, wherein the second coagulation time measurement reagent contains a metal ion and/or normal plasma, and the value is used to determine whether the blood specimen of a subject is a blood specimen containing a lupus anticoagulant or a blood specimen containing a direct anticoagulant.. .
Sysmex Corporation

Blood volume analyzer with volume-aware blood component measures

Methods and systems are presented for analyzing the blood of a living being. Equations are presented for volume-aware extension of the concept of hematocrit.
Daxor Corp.

Enhanced electrochemical detection using nanoparticles and precipitation

The invention described herein relates generally to methods, sensors, devices and kits for electrochemical detection of a target analyte in a sample. In certain aspects, the methods, sensors, devices and kits described herein can be used to detect low concentrations of at least one target analyte using small sample volumes.
President And Fellows Of Harvard College

Sntf is a blood biomarker for the diagnosis and prognosis of sports-related concussion

The invention relates to methods for providing prognosis, diagnosis, monitoring and treatment of a mild traumatic brain injury (mtbi) in a subject, including a sports-related concussion. The invention further relates to assessing the severity of brain damage resulting from mtbi in a subject, including in a subject who has not undergone a ct scan following the injury.
The Trustees Of The University Of Pennsylvania

Means and methods for the determination of the quality of blood samples based on a metabolite panel

A method for assessing the quality of a blood product sample, comprises determining in said sample the value of the markers of at least one marker panel of the invention, comparing the values determined with corresponding references, and assessing the quality of said blood sample.. .
Metanomics Health

Method for measuring hematocrit value of blood sample, measuring concentration of analyte in blood sample, sensor chip and sensor unit

Voltage is applied across a counter electrode and a working electrode, with which a blood sample is in contact, in such a state that an oxidant in a redox substance is not substantially in contact with a working electrode but is in contact with a counter electrode and a reductant is not substantially in contact with the counter electrode but is in contact with the working electrode, whereby the reductant and the oxidant are respectively oxidized and reduced to measure current produced upon the oxidation and reduction. According to the above constitution, while lowering the voltage applied across the working electrode and the counter electrode, the hct value of the blood sample can be measured stably with a satisfactory detection sensitivity.
Panasonic Healthcare Holdings Co., Ltd.

Cell counting

Systems and methods for classifying blood cells in a blood sample are disclosed. A series of frames of the blood sample as it flows through a field of view of an image capture device are captured and analysed.
Biosurfit S.a.

Lrp5 as epigenetic marker for the identification of immune cells, in particular b-cells

The present invention relates to a method, in particular an in vitro method, for identifying b cells, comprising analyzing the methylation status of at least one cpg position in the mammalian gene region for low density lipoprotein receptor-related protein 5 (lrp5), wherein a demethylation or lack of methylation of said gene region is indicative for a b cell, when compared to a non-b cell. The analyses according to the invention can identify b cells on an epi-genetic level and distinguish them from all other cells in complex samples, such as, for example, other blood or immune cells.
Epiontis Gmbh

Park2 as epigenetic marker for the identification of immune cells, in particular monocytes

The present invention relates to a method, in particular an in vitro method, for identifying monocytes, comprising analyzing the methylation status of at least one cpg position in the mammalian gene region for parkin rbr e3 ubiquitin protein ligase (park2), wherein a de-methylation or lack of methylation of said gene region is indicative for a monocyte, when compared to a non-monocyte cell. The analyses according to the invention can identify monocytes on an epigenetic level and distinguish them from all other cells in complex samples, such as, for example, other blood or immune cells.
Epiontis Gmbh

Preservation of cell-free nucleic acids

A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids..
Streck, Inc.

Methods for isolating and proliferating autologous cancer antigen-specific cd8+ t cells

Provided is a method for isolating and proliferating autologous cancer antigen-specific cd8+ t cells, and more particularly, a method for selecting an epitope recognized by cd8+ t cells from autologous cancer antigens present in blood of individual cancer patients; and isolating autologous cancer antigen-specific cd8+ t cells by using a peptide of the selected epitope, and a method of massively proliferating cd8+ t cells by using the method. According to the present invention, it is possible to isolate autologous cancer antigen-specific cd8+ t cells by using the peptide of the cd8 t cell epitope of the autologous cancer antigen present in blood of individual cancer patients instead of a heterologous antigen.
Eutilex Co., Ltd.

Method for inducing differentiation of myeloid-derived suppressor cells from cord - blood cd34 positive cells and proliferating same, and use of myeloid-derived

The present invention relates to a method for inducing differentiation myeloid-derived suppressor cells from cord blood cd34 positive cells and proliferating the same, and a use of the myeloid-derived suppressor cells. More specifically, myeloid-derived suppressor cells are induced to differentiate and proliferated by culturing cord blood cd34 positive cells in the presence of a cytokine cocktail of gm-csf and scf, such that myeloid-derived suppressor cells can be mass-produced in vitro, and the myeloid-derived suppressor cells can be used in preventing or treating immunorejection-related diseases such as graft-versus-host disease..
The Catholic University Of Korea Industry-academic Cooperation Foundation

Method for venting a dialyzer

The invention relates to a method for venting a dialyzer which has a dialyzate chamber, a blood chamber and a semi-permeable dialyzer membrane separating these two chambers, wherein an overpressure is generated in the dialyzate chamber with respect to the blood chamber for removing air inclusions lying at the surface of the membrane at the dialyzate chamber side after a filling of the dialyzate chamber and before a filling of the blood chamber.. .
Fresenius Medical Care Deutschland Gmbh

Systems and methods for collecting mononuclear cells having a suitable hematocrit for extracorporeal photopheresis

A system for collecting mncs to be treated with irradiation comprises a fluid circuit comprising a product container for receiving a mnc product. The system comprises a separator to work in association with the fluid circuit, the separator comprising a chamber for separation into rbcs, plasma, and an interface carrying mncs between the rbcs and the plasma.
Fenwal, Inc.

Renal therapy machine and method including a priming sequence

A method for priming a renal therapy machine is disclosed. The method includes communicating a source of a physiologically compatible solution with a blood circuit and moving the physiologically compatible solution from the source to the blood circuit.
Baxter Healthcare Sa

Methods and compositions for blood vessel tissue repair and engineering

The present disclosure provides methods, substrates and compositions for modifying, repairing, and/or engineering blood vessel tissue, and in particular the use of such compositions for treating a diseased blood vessel.. .
Xeltis, Bv

Method of preparing physiologically active polypeptide conjugate

Provided is a method of preparing a physiologically active polypeptide conjugate, in which a physiologically active polypeptide and a non-peptidyl polymer are linked to each other via a covalent bond. The method is to improve an overall yield of the physiologically active polypeptide conjugate by improving a reaction of the non-peptidyl polymer and the physiologically active polypeptide, and particularly, the method is to prepare a physiologically active polypeptide conjugate in a high yield by performing a two-step reaction through selective precipitation.
Hanmi Pharm. Co., Ltd.

Health supplement food for promotion of hair growth, mitigation and alleviation of hair loss, regulation of blood glucose, and alleviation and relief of gastric disorder symptoms

The present invention relates to a health supplement food. More particularly, the present invention relates to a health supplement food prepared by mixing dried powders, wherein the dried powders include 5 to 15% by weight of black beans, 5 to 15% by weight of black sesame seeds, 5 to 15% by weight of corn, 5 to 15% by weight of adlay, 5 to 15% by weight of sorghum, 5 to 15% by weight of mulberry leaves, 5 to 15% by weight of mulberry fruits, 7 to 20% by weight of polygonum multiflorum thunberg, 5 to % by weight of dandelion, 1 to 10% by weight of licorice, 2 to 15% by weight of kelp, and 5 to 15% by weight of cactus based on solid content.

Microporous zirconium silicate for the treatment of hyperkalemia

The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. Potassium ions, from the gastrointestinal tract at an elevated rate without causing undesirable side effects.
Zs Pharma, Inc.

Thrombin-responsive hydrogels and devices for auto-anticoagulant regulation

The present disclosure relates to a thrombin-responsive closed-loop patch for prolonged heparin delivery in a feedback-controlled manner. The microneedle-based patch can sense the activated thrombin and subsequently release heparin to prevent coagulation in the blood flow.
The University Of North Carolina At Chapel Hill

Blood-brain-barrier permeability modulators and uses thereof

Provided are compositions which include n-methyl-d-aspartate receptor (nmda-r) antagonists. Moreover, provided are methods for reducing the permeability of the blood-brain-barrier, in a patient, by administering to the patient, a composition which includes n-methyl-d-aspartate receptor (nmda-r) antagonists..
B.g. Negev Technologies And Applications Ltd. At Ben-gurion University

Composition for treating diabetes mellitus

The treatment of diabetes mellitus with excellent hypoglycemic effect that suppresses lactic acidosis without substantially increasing the blood lactate concentration. A composition for treating diabetes mellitus with hypoglycemic effect that suppresses lactic acidosis without substantially increasing the blood lactate concentration, and the composition has branched-chain amino acids and salts of biguanide derivatives and derivatives of biguanide derivatives or branched-chain amino acids as the active components.

Prosthesis for improved penis function

A subcutaneous prosthesis subcutaneously implanted within a penis, the prosthesis forming two sides of an elongated cylinder, the sides hinged along top longitudinal edges of their sides. One end of the prosthesis has a gauze sheath providing a means to secure the prosthesis from moving relative to the corpora cavernosa around which it is placed.
Menova International, Inc.

Bifurcated stent graft with hemodynamic blood flow dividing wall

A bifurcated stent graft includes a stent graft body that defines exactly one main body opening and at least two exit openings. The stent graft body includes at least one stent attached to a graft fabric material, and includes a dividing wall that divides a combined flow path, into a first flow path and a second flow path that each terminate at one of the respective exit openings.
Cook Medical Technologies Llc

System for stimulating renal nerves

The invention relates to a system (1) for stimulating renal nerves of a renal artery of a subject (3). The system comprises a stimulation device (12, 17, 28) for stimulating the renal nerves, a measuring unit (20) for measuring the blood pressure and/or the heart rate of the subject at at least two times, wherein at least one of these times is during or after the stimulation of the renal nerves, and a subject suitability determination unit (14) for determining whether the subject is suitable for a renal sympathetic denervation procedure based on the measured blood pressure and/or the measured heart rate.
Koninklijke Philips N.v.

Apparatus and treating a blood vessel

An ablating element for use with an ablating system employable within a hollow anatomical region. The ablating element includes an elongated support body having a central axis; and, at least one thermocouple wrapped around the central body.
Sierra Medical International, Inc.

Wearable emergency hemorrhage cessation systems

A wearable system comprises tourniquets. Each of the tourniquets comprises an inflatable chamber, and is configured to occlude blood flow in an artery of a wearer.

Percutaneous vascular injury treatment systems and methods

The present invention relates to a compressive band and hemostatic dressing system and related methods of use to provide rapid, non-occlusive bleeding control, arterial injury treatment, and injury protection comfortably and reliably after vascular access procedures. The present invention may comprise some or all of the following elements: a positioner assembly, a compressive cushion component, a compression plate, a strap with a flexible hinge assembly, and a hemostatic dressing.
Tricol Biomedical, Inc.

Implantable damping devices for treating dementia and associated systems and methods of use

Devices, systems, and methods for reducing stress on a blood vessel are disclosed herein. A damping device configured in accordance with embodiments of the present technology can include an anchoring member coupled to a flexible, compliant damping member including a generally tubular sidewall having an outer surface, an inner surface defining a lumen configured to direct blood flow, a first end portion and a second end portion, and a damping region between the first and second end portions, the inner and outer surfaces of the damping member can be spaced apart by a distance that is greater at the damping region than at either of the first or second end.
The Brain Protection Company Pty Ltd

Ultrasound and photoacoustic fetal brain assessment during delivery

Methods and system are described for multi-parametric, non-invasive, and real-time assessment of blood perfusion and oxygenation in the fetal brain during labor and delivery of a fetus through a vaginal birth canal of a maternal pelvis, and include positioning a probe device in the maternal pelvis during active labor, transmitting and receiving a plurality of ultrasound (us) and photoacoustic (pa) signals between the probe device and fetal brain, displaying in real-time on an us machine communicatively coupled to the probe device one or more images of venous and arterial blood flow of respective blood vessels in the fetal brain, measuring oxygen saturation of the respective venous and arterial blood vessels based on data from the one or more images, and estimating the oxygen measurement in the fetal brain during active labor based on the measured oxygen saturation.. .
Wayne State University

Ultrasound diagnosis apparatus, image processing apparatus, and image processing method

An ultrasound diagnosis apparatus includes: transmission and reception circuitry that generates reception signals corresponding to channels, from reflected waves arranged to be received at mutually the same time by transducer elements that transmitted an ultrasound wave, by controlling transducer elements included in an ultrasound probe; extracting circuitry that extracts, prior to a beam forming process, first signals corresponding to the channels from the reception signals corresponding to the channels while suppressing signals originating from a tissue and further extracts a second signal by performing the beam forming process after suppressing, of the extracted first signals corresponding to the channels, a component in a predetermined direction; calculating circuitry that calculates blood flow information from the second signal; and controlling circuitry that generates a blood flow image from the blood flow information and causes display to display the generated blood flow image.. .
Canon Medical Systems Corporation

X-ray imaging apparatus and x-ray image analysis

An x-ray imaging apparatus includes an x-ray irradiation element, an x-ray detection element, an x-ray image generation element, and an image processing analysis element. The image processing analysis element reflects the analysis point on each frame based on a respective relative location between a characteristic point 10 of the x-ray image consisting of a plurality of frames.
Shimadzu Corporation

A medical placement alarm

Many medical procedures involve the implantation of an element in a vascular body. Current imaging techniques allow the positioning of such expandable elements to be checked, before and after implantation, using contrast bursts into the blood from a pigtail catheter.
Koninklijke Philips N.v.

System and obtaining health data using a neural network

A photoplethysmography (ppg) circuit or non-contact camera obtains ppg signals at a plurality of wavelengths. A signal processing module obtains at least a first spectral response around a first wavelength and a second spectral response around a second wavelength.
Sanmina Corporation

Neck-worn physiological monitor

The invention provides a neck-worn sensor that is a single, body-worn system that measures the following parameters from an ambulatory patient: heart rate, pulse rate, pulse oximetry, respiratory rate, temperature, thoracic fluid levels, stroke volume, cardiac output, and a parameter sensitive to blood pressure called pulse transit time. From stroke volume, a first algorithm employing a linear model can estimate the patient's pulse pressure.
Tosense, Inc.

Vein imager with a dual buffer mode of operation

The present invention is a miniature vein enhancer that includes a miniature projection head. The miniature projection head may be operated in one of three modes, afm, dbm, and rtm.
Accuvein, Inc.

Membrane catheter

A catheter for intravascular use has a blood inlet and a blood outlet, and includes a membrane arranged in the catheter in such a way that at least one part of the blood flowing into the catheter via the blood inlet during operation comes into contact with the membrane. The membrane allows an exchange of at least one substance between a carrier medium and the blood.
Ccore Technology Gmbh

Determining blood pulse characteristics based on stethoscope data

Techniques for determining pulse transit time (ptt) and blood pressure measurements based on stethoscope data are provided. In one example, a system comprises a stethoscope component that monitors a heart and generates stethoscope data representative of a sound wave generated by the heart.
International Business Machines Corporation

Determining blood pulse characteristics based on stethoscope data

Techniques for determining pulse transit time (ptt) and blood pressure measurements based on stethoscope data are provided. In one example, a system comprises a stethoscope component that monitors a heart and generates stethoscope data representative of a sound wave generated by the heart.
International Business Machines Corporation

Apparatus and determining blood pressure

An apparatus and method for determining blood pressure has a control unit and a device for providing pulse wave data representative of a heart beat of a human subject. The subject has a body height, an age, and a gender.
Preventicus Gmbh

Applications of hyperspectral laser speckle imaging

Systems and methods are provided for detecting the flow of blood or other fluids in biological tissue by illuminating the biological tissue with two or more beams of coherent light and detecting responsively emitted light. A difference in wavelength, coherence length, beam divergence, or some other property of the beams of illumination causes the beams to preferentially scatter from, be absorbed by, or otherwise interact with respective elements of the biological tissue.
Verily Life Sciences Llc

Endoscope system and operation endoscope system

The image acquisition unit acquires an image captured by an endoscope. The extraction unit extracts a blood vessel of an observation target.
Fujifilm Corporation

Image processing apparatus, endoscope system, and image processing method

An image processing apparatus includes: an image acquisition unit that acquires a plurality of endoscope images obtained by imaging an observation target at different times with an endoscope; a blood vessel extraction unit that extracts blood vessels from the plurality of endoscope images; a blood vessel index value calculation unit that calculates a blood vessel index value for each of the blood vessels extracted from the endoscope images; a temporal change calculation unit that calculates a temporal change of the blood vessel index value; a determination unit that determines a state of a mucous membrane of the observation target using the temporal change of the blood vessel index value; and a monitor that displays a determination result of the determination unit.. .
Fujifilm Corporation

Image processing apparatus, endoscope system, and image processing method

An image processing apparatus includes an image acquisition unit that acquires an endoscope image, a blood vessel extraction unit that extracts a blood vessel at a specific depth of the observation target from the endoscope image, a blood vessel information calculation unit that calculates blood vessel information regarding the blood vessel extracted by the blood vessel extraction unit, and a blood vessel parameter calculation unit that calculates a blood vessel parameter, which is relevant to the blood vessel at the specific depth, by calculation using the blood vessel information.. .

Ketogenic nutritional composition and preparation method thereof

The present disclosure relates to nutritional composition in powder form capable of being used as an adjunct to a ketogenic diet program. The disclosed ketogenic nutritional composition can produce elevated and sustained levels of ketone bodies in blood and can synergistically induce nutritional ketosis in a subject.

Compositions for controlling mosquito populations

Methods are disclosed herein for at least one of (i) substantially reducing plasmodium and/or oocyst development, (ii) substantially reducing mating success, (iii) substantially abolishing egg development after blood feeding, (iv) substantially reducing the mean survival rate; (v) substantially reducing at least one of the transmission of mosquito borne pathogens; and (vi) substantially reducing the propensity for mosquito biting comprising contacting adult, female mosquitoes with a composition comprising an effective amount of one or more non-steroidal ecdysone agonists. The one or more non-steroidal ecdysone agonists can be comprised indoor or outdoor surface..
President And Fellows Of Harvard College

Walters Gardens, Inc.

. .

Blood vessel positioning device and method thereof

A blood vessel positioning device includes an ir image capturing unit, an image-processing unit and an image projector unit. The ir image capturing unit is provided to capture an ir image of a skin area.
National Kaohsiung University Of Applied Sciences

Method and system for analyzing blood flow condition

The present application relates to a method and system for analyzing blood flow conditions. The method includes: obtaining images at multiple time phases; constructing multiple vascular models corresponding to the multiple time phases; correlating the multiple vascular models; setting boundary conditions of the multiple vascular models respectively based on the result of correlation; and determining condition of blood vessel of the vascular models..
Shanghai United Imaging Healthcare Co., Ltd.

Method and system for analyzing blood flow condition

The present application relates to a method and system for analyzing blood flow conditions. The method includes: obtaining images at multiple time phases; constructing multiple vascular models corresponding to the multiple time phases; correlating the multiple vascular models; setting boundary conditions of the multiple vascular models respectively based on the result of correlation; and determining condition of blood vessel of the vascular models..
Shanghai United Imaging Healthcare Co., Ltd.

Image processing apparatus, endoscope system, and image processing method

An image processing apparatus includes: an image acquisition unit that acquires a plurality of endoscope images obtained by imaging an observation target at different times with an endoscope; a blood vessel extraction unit that extracts blood vessels of the observation target from the plurality of endoscope images; a blood vessel information calculation unit that calculates a plurality of pieces of blood vessel information for each of the blood vessels extracted from the endoscope images; a blood vessel parameter calculation unit that calculates a blood vessel parameter, which is relevant to the blood vessel extracted from each of the endoscope images, by calculation using the blood vessel information; and a blood vessel change index calculation unit that calculates a blood vessel change index, which indicates a temporal change of the blood vessel, using the blood vessel parameter.. .
Fujifilm Corporation

Automatic quality control device of blood cell analyzer

Provided is a technique for automatically performing quality control of a blood cell analyzer so as to minimize waste of time and manpower and quality control errors through automation of everyday repetitive quality control tasks. According to an embodiment of the present invention, an automatic quality control device of a blood cell analyzer includes: a reagent storage unit installed on the blood cell analyzer and configured to refrigerate and store at least one reagent for use in quality control of the blood cell analyzer; a transfer device installed between the reagent storage unit and a blood cell test unit of the blood cell analyzer for moving the at least one reagent from the reagent storage unit to the blood cell test unit of the blood cell analyzer; and a quality control controller configured to control an operation of the transfer device, receive from the blood cell test unit information about results of a quality control test performed using the at least one reagent to determine whether the quality control test is passed, and output information about results of the determination whether the quality control test is passed through an output device of the blood cell analyzer..
The Catholic University Of Korea Industry-academic Cooperation Foundation

Methods for assaying palmitoyl protein thioesterase 1 and tripeptidyl peptidase activity in dried blood spots for detection of neuronal ceroid lipofuscinoses in newborns

The present disclosure provides assays for lysosomal enzymes, specifically palmitoyl protein thioesterase 1 (ppt1) and tripeptidyl peptidase 1 (tpp1), using, for example, tandem mass spectrometry. The assays involve the detection of enzymatic products obtained through the action of the lysosomal enzymes on new enzyme substrates, and can be used for quantitative enzyme activity measurements.
University Of Washington

Universal, non-invasive, early detection system for cancers

The present invention provides a universal system that detects cancer cells at all stages including early developmental stages as well as matured cancerous tumors. The system relates to monitoring the environment surrounding abnormally metabolizing cells, e.g., predominantly glycolytic cells, cancerous cells, precancerous cells, and/or cells with reduced mitochondrial electron transport chain activity.

Method of determining, identifying or isolating cell-penetrating peptides

The present invention provides a method of determining or identifying or isolating a cell-penetrating peptide (cpp) or analog or derivative thereof having cell-type selectivity and/or at least capable of passing through a blood brain barrier of an animal subject. This invention also provides cpps and analogs and derivatives thereof, such as those set forth in seq id nos: 1-27 of the sequence listing, and compositions comprising one or more of the cpps, including conjugates in which a cpp or analog or derivative thereof is linked to a cargo molecule.
Phylogica Limited

Binding assay signal analysis

Methods for determining a sample concentration of target entities in a sample, for example, determining a concentration of target antigens or antibodies in a blood sample or other biological sample.. .
Biosurfit, S.a.

Streptococcus pneumoniae detection in blood

A set of primers is for amplifying and detecting a s. Pneumoniae ribonucleic acid in a sample.
Universite Libre De Bruxelles

Chemiluminescence-based haemostasis assay

The present invention relates to a method for in vitro determining generation of a haemostasis factor such as thrombin and/or plasmin in a test sample using a chemiluminescent substrate specific for said blood clotting factor. Upon cleavage of the substrate, a luminescent signal is generated with the aid of a luciferase.
Chiralix B.v.

Pyrrolo[2,3-d]pyrimidine compound or salt thereof

Provided are a novel compound or a salt thereof, and a pharmaceutical composition comprising the same, which selectively and strongly inhibit jak3, exhibit an excellent activity for suppressing the growth of human peripheral blood monocytes and an excellent oral absorbability, and exhibits an activity of inhibiting il-2-induced ifn-γ production in vivo. A compound represented by formula (i) [wherein x represents —ch═ch—, —nh—, a sulfur atom or an oxygen atom; and n represents an integer of 0 to 2], or a salt thereof..
Taiho Pharmaceutical Co., Ltd.

Bis-furan derivatives as transthyretin (ttr) stabilizers and amyloid inhibitors for the treatment of familial amyloid polyneuropathy (fap)

The design and synthesis of a novel bis-furan scaffold tailored for high efficiency at inhibiting transthyretin amyloid formation is reported. In vitro results show that the discovered compounds are more efficient inhibitors of amyloid formation than tafamidis, a drug currently used in the treatment of familial amyloid polyneuropathy (fap), despite their lower molecular weight and lipophilicity.
Bsim2 - Biomolecular Simulations, S.a.

Method for producing organic urea and the organic urea and aus32 thereby obtained

A method for producing organic urea is provided that, by mixing and reacting liquid ammonia (nh3) and gaseous carbon dioxide (co2) through the steps of ammonium carbamate formation (5), carbamate decomposition (7), urea synthesis (8) and evaporation (9) thereof, is carried out using organic ammonia from animal and plant biomass (2) and carbon dioxide recycled from the exhaust gases (6) from combined-cycle biogas boilers with plant biomass. The steps preceding the organic urea production include methanization (1), with a biomass “digester”, mixing with pig and chicken slurry and blood, pine needles and ash, and water, until obtaining: methane gas, air, gaseous ammonia and water vapor and ph regulator and catalyzing (3), where the obtained gases are condensed by cooling and the gaseous ammonia is separated to be stored at a pressure of 13 atmospheres.

Automatic plasma separation and metering

A new method is disclosed for extracting plasma from whole blood and metering the amount of plasma to an exact volume for dispensing into a diagnostic test, in a fully automatic and self-contained device. The device can be used in resource limited settings by unskilled users to facilitate sophisticated medical diagnostic testing outside of a hospital, clinic or laboratory..

Microdevice for separating plasma from human blood

A microdevice for separating plasma from human blood comprising a blood flow channel (2) connected to a corpuscles flow channel (5) and a plasma flow channel (8) through a curved construction channel (15). Blood flow channel has width 150 to 400 μm and length 1-20 mm, constriction channel (15) has width 60 to 200 μm, length 0.157 to 3.15 mm and curvature angle 90-270° with inner radius 50 μm to 1 mm and outer radius 110 μm to 1.2 mm and corpuscles flow channel (5) has width 200 to 700 μm, length 0.5 to 5 mm and bend angle 40-70°.
Indian Institute Of Technology, Bombay

Blood separation media and lateral flow devices for blood samples

Blood separation media include a fibrous web formed by 50 to 99 parts by weight of glass microfibers, and 1 to 50 parts by weight of fibrillated fibers; a polymeric, hydrophilic binder; a wetting agent; and a salt. The binder covers at least a part of the glass microfibers, and the web is further impregnated with a wetting agent and it contains a salt which is capable of crenating red blood cells.
Ahlstrom Corporation

Systems and methods for removal of blood and thrombotic material

A system for aspirating thrombus includes an aspiration catheter including a supply lumen and an aspiration lumen each extending within an elongate shaft, and an opening at or near the distal end of the supply lumen, the opening configured to allow the injection of pressurized fluid into the aspiration lumen at or near the distal end of the aspiration lumen when the pressurized fluid is pumped through the supply lumen, a tubing set including tubing and having a distal end configured to couple to the aspiration lumen of the aspiration catheter and a proximal end configured to couple to a vacuum source, a tubing compression element configured to externally engage the tubing of the tubing set, and an activation interface configured to activate the tubing compression element to compress the tubing at a location between the proximal end of the tubing set and the distal end of the tubing set.. .
Walk Vascular, Llc

Portable ultrafiltration unit and device for supplying the ultrafiltration unit with dialysis fluid

The invention relates to a portable ultrafiltration unit a which comprises a blood pump 7 for conveying blood and an ultrafiltration pump 6 for conveying ultrafiltrate. The invention further relates to a stationary device b for supplying dialysate to the portable ultrafiltration unit a, and to a medical treatment system which comprises an ultrafiltration unit and a device for supplying dialysate to the ultrafiltration unit.
Fresenius Medical Care Deutschland Gmbh

Artificial lung

An artificial lung 100 has a filling portion 110 that communicates with an inlet port 101 and an outlet port 102 for blood and is filled with blood, a heat exchange portion 160 that includes a bundle of a plurality of hollow fibers 163 for heat exchange and is provided inside the filling portion, a gas exchange portion 170 that includes a bundle of a plurality of hollow fibers 173 for gas exchange and is provided inside the filling portion to be adjacent to the heat exchange portion, and a porous member 180 that is disposed in a gap 190 between the heat exchange portion and the gas exchange portion. A volume within the housing occupied by a wall of the porous member correspondingly reduces a priming volume within the housing available for conveying the blood (i.e., a bulk volume of the porous member partially blocks or fills the gap..
Terumo Kabushiki Kaisha

Blood treatment device

The present invention relates to a blood treatment device having a heat exchanger which has a first space and a second space, wherein the first space is flowed through by a first fluid and the second space is flowed through by a second fluid, and wherein the heat exchanger has a membrane which separates the first space from the second space, wherein the membrane forms a component of a capacitor which has two capacitor plates between which the membrane is located, and wherein monitoring means are provided which are connected to the capacitor and which are configured such that they detect an electrical property of the capacitor for the purpose of detecting a leak from the first space to the second space.. .
Fresenius Medical Care Deutschland Gmbh

Counterpulsation device driver apparatus, method and system

A method of operating a counterpulsation device (cpd) in a human or animal subject is disclosed, the method including: receiving a heart beat signal indicative of the heart beat of the subject; providing counterpulsation therapy by controlling the pressure supplied to a cpd drive line in pneumatic communication with the cpd to cause the cpd to alternately fill with blood and eject blood with a timing that is determined at least in part based on the heart beat signal; while providing counterpulsation therapy, receiving a cpd drive line pressure signal indicative of the pressure in the cpd drive line; and adjusting the pressure supplied to the drive line based at least in part on the drive line pressure signal.. .
Abiomed, Inc.

Cardiac assist device

A cardiac pump and an assist system is provided that increases blood ejection from a compromised heart. An implantable cardiac pump acting as an assist device provided includes an attachment system and locating features that enable a minimally invasive procedure to implant and deploy one or more aortic blood pumps in a patient.
Viaderm Llc

Intracardiac pumping device

The invention relates to an intercardiac pump device comprising a pump (11) whose distal end (13) is connected to a cannula (15) which is provided with a suction head (16) for sucking blood. Said strainer is provided with a non-sucking extension (20) for stabilising the position of said pump device in the heart and mechanically prolonging the cannula (15) without deteriorating hydraulic conditions.
Abiomed Europe Gmbh

Coated endovascular devices

The present disclosure relates to the field of medical treatment. More particularly, the current invention delivers medication via a coating via a hydrogel infused with pharmaceutical compounds into the bloodstream to promote the supply to the distal vascular bed beyond the stent.

Compositions and methods for treating post-operative complications of cardiopulmonary surgery

A method for preventing bleeding, blood-brain barrier disruption, brain injury, or a combination thereof in a subject destined for cardiac surgery is disclosed. The method involves administering to the subject prior to cardiac surgery a therapeutically effective amount of alpha-1 antitrypsin (aat-1), or functional variant thereof.
Mor Research Applications Ltd.

Methods and compositions using gdf15 polypeptides for increasing red blood cells

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.. .
Acceleron Pharma Inc.

Compositions and methods of using krill powder in cardiovascular regulation

The present invention is related to the regulation of the cardiovascular system. In particular, to krill powder compositions and their administration to mammal for regulation of blood pressure..
Rimfrost Technologies As

Substance and modulating proliferation and differentiation of regulatory, stem and other somatic cells

The invention relates to the field of basic biology, practical regenerative medicine, veterinary, cell biology and can be used to treat and prevent diseases, disorders or conditions associated with the violation of proliferation and differentiation of cells of different organs and tissues to activate the regeneration potential of human and animal organs and tissues at age- related changes and after extreme impacts, as well as for biomedical research. The present invention can be widely applied in the field of blood transfusion, organ transplantation, as well as serve as a general approach to the development of reliable methods to correct age-related changes in the elderly.
Aovart Gmbh

Portable therapeutic mat with thermochromic properties

A portable therapeutic massage mat includes a base and a plurality of protrusions extending from the base. The protrusions may have a square pyramidal shape or other suitable shapes.
Sweetcheeks Products, Inc.

Microwave coaptive surgical sealing tool

A coaptive surgical sealing tool may be similar to an ordinary hemostat with long (50, 60, 70 or 80 mm) thin jaws for sliding into the liver parenchyma, without tearing the larger blood vessels. The jaws are spring loaded and are designed for uniform compression, and to avoid closing too quickly.
City Of Hope

Thermally stable ich imaging device

A cannula system and method for accessing a blood mass in the brain. The system comprises a cannula with a camera mounted on the proximal end of the cannula with a view into the cannula lumen and the surgical field below the lumen.
Rebound Therapeutics Corporation

Devices, creation of a peripherally located fistula

Devices, systems and methods are disclosed for the formation of an arteriovenous fistula in the limb of the patient. Embodiments include a device for the creation, modification and maintenance of a fistula that includes an integral fistula creation assembly near its distal end that passes through the skin of the patient, through a first vessel such as an artery, and into a second vessel such as a vein.
Rox Medical, Inc.

Stenosis assessment

The present invention relates to improved assessment of a stenosis in a blood vessel in a body by comparing hemodynamic properties of the stenosed blood vessel with a substantially symmetric different blood vessel in the same body.. .
Koninklijke Philips N.v.

Optical patient monitor

An optical based patient monitoring system employing an optical sensor and providing an indication of an optical change which does not correlate to a change in a physiological blood parameter and based on that indication, providing a care provider an indication of a condition of a patient. The optical based patient monitoring system providing the indication of the patient condition in relation to a patient using an iv setup..
Masimo Corporation

Method and correction of non-invasive blood glucose measurement

Correction of a non-invasive blood glucose measurement measured from a video image. Correction includes irradiating white light on the skin, filtering the white light reflected from the skin by a first wavelength filter and a second wavelength filter, obtaining a first signal including a blood glucose signal and a pulse signal based on a video image generated by the white light filtered by the first wavelength filter, obtaining a second signal including a pulse signal based on a video image generated by the white light filtered by the second wavelength filter, obtaining a blood glucose signal by subtracting the second signal from the first signal, and calculating the amount of blood glucose in a subcutaneous blood vessel based on the obtained blood glucose signal.
Iism Inc.

Transducer for noninvasive measurement of glucose in blood

A system for noninvasive measurement of glucose in blood. The system is based in a sensor of the invention.
Inis Biotech Llc

Digital artery blood pressure monitor

An example of a digital artery blood pressure monitor may include a tactile sensor array disposed on an inner surface of a cuff, the tactile sensor array including a plurality of capacitive sensors to detect pressure changes within a digital artery of a finger due to blood flow, where the pressure changes cause changes to capacitance values of one or more capacitive sensors of the tactile sensor array, and control circuitry coupled to the tactile sensor array to receive the capacitance values from the tactile sensor array, and determine a blood pressure based on the capacitance values.. .
Verily Life Sciences Llc

Blood pressure measuring apparatus

A pressurizing/depressurizing section (4) performs at least one of air feeding to a cuff (20) by way of an air way (3) and air discharging by way of the air way (3) to thereby increase or decrease an internal pressure of the cuff (20). A first controlling section (5) causes the pressurizing/depressurizing section (4) to initiate the air feeding while performing the air discharging to thereby cause the internal pressure to transit from a pressure transient state to a pressure steady state or from the pressure steady state to the pressure transient state.
Nihon Kohden Corporation

Bloodstream detecting device and bloodstream detector used therein

A bloodstream detector includes a covering sheet, light emitters, light receivers, an orientation sensor, and a signal output interface. The covering sheet includes a detection surface.

Cancer invasiveness diagnosis system

A cancer invasiveness diagnosis system includes an endoscope; a microtomography probe which is introduced into a body cavity together with the endoscope, the microtomography probe emitting a low-coherence light on a target tissue in which a target tumor is present to obtain an optical interference signal; a determination portion which is configured to obtain a tomography image of the target tissue including the target tumor and a blood flow velocity information in a blood vessel in the tomography image based on the optical interference signal, wherein the determination portion is configured to determine the cancer invasiveness of the target tumor based on the tomography image and the blood flow velocity information.. .
Osaka City University

Apparatus and imaging and analyzing hemodynamics

The present invention images a heartbeat strength representing the strength of pulsations (beats) on a map as a new dynamics index different from the conventional waveform numerical value. A computation section according to the present invention obtains, from time-course changes of the blood flow map obtained as a result of computation of blood flow speed, a signal intensity at a fundamental frequency determined from time-series blood flow data within a predetermined region, and calculates a heartbeat strength which represents the strength of heartbeats on the basis of the signal intensity.
Softcare Co., Ltd.

Endoscope system and operating endoscope system

An image processing unit includes an image acquisition unit, a blood vessel index value acquisition unit, and a blood vessel parameter calculation unit. The image acquisition unit acquires an endoscopic image captured by an endoscope.
Fujifilm Corporation

Blood pressure measurement device and method

A blood pressure measurement device includes a body, a film-type pressure sensing unit, a first electrode, and a second electrode. The body includes a pulse sensing surface and a concave portion.
Maisense Inc.

Head-mounted device for capturing pulse data

Examples are disclosed herein related to a head-mounted device, such as wearable eyeglasses, to continuously monitor pulse data and blood pressure data. One example provides a head-mounted device, comprising a first optical sensor positioned to measure pulse data at a first arterial location that is a first distance from a heart, a second optical sensor spaced apart from the first optical sensor and positioned to measure pulse data at a second arterial location that is a second, different distance from the heart, and a controller wired to the first optical sensor and the second optical sensor and configured to determine blood pressure data from the pulse data measured by the first optical sensor and the second optical sensor..
Microsoft Technology Licensing, Llc

Wrist type measurement of cardiovascular health, system, and method thereof

The disclosure is related to a wrist type apparatus, and a system for measurement of cardiovascular health, and a method for the same. The wrist type apparatus is preferably a wrist type blood pressure device that includes an electrode-based module and a piezoelectric sensor module.
Kentec Inc.

Pressure sensor and blood pressure measurement device

A pressure sensor and a blood pressure measurement device with the pressure sensor are disclosed. The pressure sensor includes a case and a pressure sensing element.
Maisense Inc.

Cannula with proximally mounted camera and transparent obturator

A cannula system and method for accessing a blood mass in the brain. The system comprises a cannula with a camera mounted on the proximal end of the cannula with a view into the cannula lumen and the surgical field below the lumen.
Rebound Therapeutics Corporation

Zero gravity chaise chair system and method

A zero gravity chaise chair includes a seat frame providing a head rest, a back, a bottom and a leg rest, a first bow member connected to one side of the seat frame, a second bow member connected to the other side of the seat frame, a first rolling guide connected to the first bow, a second rolling guide connected to the second bow, and a base connected to the first rolling guide and the second rolling guide. A motor may operate the first rolling guide to vary incline position of the seat frame.
Jolozero Llc

Fishing lure system and kit having replaceable features and construction

A flexible fishing lure is provided that includes a outer shape having a transverse opening for receiving a plurality of alternatively formed lure fin members allowing a user to change the action of a lure by fin selection without replacing the lure. Multiple internal channels within the lure are adaptively provided for receiving a variety of scent sticks, sound generators, light generators, flavor generating means.

Extracorporeal blood treatment machine

A machine for extracorporeal blood treatment includes a user interface having a touch screen and a controller programmed to display on a screen (16) a display in which two distinct areas are arranged, one of which (161) exhibits a series of touch keys (17), wherein activation of any one touch key (17) causes visualization of an image in a second area (162) of the screen, wherein the images are displayed alternatively and are at least partly different one from another, wherein each touch key (17) is associated to an instruction, or to a group of instructions, each concerned with readying the machine for use, wherein each image is a pictograph of a configuration of the machine, correlated with an instruction associated to the touch key (17) selected, and wherein the operator is aided in making the machine ready for treatment.. .
Gambro Lundia Ab

Blood vessel image processing apparatus, blood vessel image processing program, and blood vessel image processing method

A control device defines, for three-dimensional blood vessel data of a blood vessel corresponding to a branched center line, a cylindrical coordinate system, thereby converting this into blood vessel data in an orthogonal coordinate system. The control device uses a coordinate value of the coordinate axis in a radial direction at a first coordinate value of the coordinate axis in a center line direction and a coordinate value of the coordinate axis in the radial direction at a second coordinate value of the coordinate axis in the center line direction, thereby interpolating a coordinate value of the coordinate axis in the radial direction between the first coordinate value and the second coordinate value.
Pentas Inc.

Dynamic image processing system

A dynamic image processing system including a hardware processor that extracts a heart region from a chest dynamic image which is obtained by radiation imaging of a dynamic state at a chest, extracts a density waveform for each pixel in the extracted heart region, determines an extraction target candidate region of blood flow information based on the extracted density waveform for each pixel, and sets an extraction target region of the blood flow information in the determined extraction target candidate region of the blood flow information.. .
Konica Minolta, Inc.

Compositions for detecting circulating integrin beta-3 biomarker and methods for detecting cancers and assessing tumor presence or progression, cancer drug resistance and tumor stemness

Provided are compositions, including kits, and methods comprising use of a biomarker β3 integrin, including the αvβ3 integrin, for detecting circulating tumor cells (ctcs), tumor stem cells, extracellular vesicles (ev), including exosomes and microvesicles, that are released by ctcs or cancer cells, as well as the tumor from which the ctcs or evs derive, and to make a patient prognosis, and to assess tumor progression, and drug resistance (for example, resistance to tyrosine kinase inhibitors), e.g., for several cancers including: breast, colon, lung and pancreatic cancers. In alternative embodiments, a patient fluid sample, e.g., a blood, serum, urine, csf or other sample, is taken and used to detect cancer stem cells, evs- and/or ctcs-comprising β3 integrin and/or a αvβ3 integrin.
The Regents Of The University Of California

Device, managing treatment of an inflammatory autoimmune disease of a person

The present invention relates to a device, system and method for managing treatment of an inflammatory autoimmune disease of a person. The proposed device comprises an input unit (20) for receiving measurement data acquired over time including white blood cell count data related to the person's white blood cell count, tumor necrotic factor-α data related to the person's tumor necrotic factor-α, c-reactive protein data related to the person's c-reactive protein, cortisol level data related to the person's cortisol level and melatonin data related to the person's melatonin concentration.
Koninklijke Philips N.v.

Bioenergetic profiling of circulating blood cells and systems, devices, and methods relating thereto

The invention relates generally to systems and methods of bioenergetic profiling, uses thereof, and systems and devices relating thereto. In particular, methods of the invention are useful in assessing wellness, particularly in elderly subjects.
Wake Forest University Health Sciences

Diagnostic test stystem for specific, sensitive and reproducible detection of circulating nucleic acids in whole blood

The present disclosure relates to a rapid diagnostic test system that includes the prospective collection of whole blood, preservation of circulating nucleic acids at ambient temperature, and the reproducible detection of nucleic acids including dna and mrna (including fusion transcripts and differentially expressed transcripts) by different genomic methodologies.. .
Biodesix, Inc.

Identification of factors for the treatment of mitochondrial and age-related diseases

The present disclosure provides a method of identifying factors for the treatment of mitochondrial and age-related diseases and disorders. Identification of the factors can comprise, e.g., biochemical, genomic, transcriptomic, proteomic and metabolomic analyses.
Cytegen Corporation

Kit, apparatus, and detecting chromosome aneuploidy

A kit, an apparatus, and a method for detecting chromosome aneuploidy. The method comprises: sequencing the peripheral blood cell-free dna of a pregnant woman to be tested to produce sequencing data comprising all chromosomes; calculating a coverage for all of the chromosomes in the sequencing data by segmenting the chromosomes into windows so as to produce a pre-correction coverage for the each chromosome; calculating a zcnv value using the number of unique sequences in each window and producing fragments with copy number variation of the pregnant woman on the basis of the magnitude of the zcnv value; by utilizing the impact that the fragments with copy number variation have on the pre-correction coverage, correcting the pre-correction coverage to produce a corrected coverage; calculating a zaneu value for the each chromosome by utilizing the corrected coverage of the each chromosome; and, if the absolute value of the zaneu value is greater than or equal to 3, then it is determined that the chromosome has an aneuploidy..
Annoroad Gene Technology (beijing) Co., Ltd.

Cell-holding container and cell culture method using same

A cell-holding container comprises: an elastic body for holding cells including at least any one of adherent cells at least one selected from the group consisting of stem cells, progenitor cells, somatic cells and germ cells, and suspended cells at least one selected from the group consisting of blood cells, t cells and b cells; and the elastic body is formed of a rubber material containing a rubber component including an additional crosslinking silicone rubber and is able to hold the cells.. .
Asahi Rubber Inc.

Delivery of materials to anucleate cells

The current subject matter includes methods, systems, articles, and techniques to deliver material to anucleate cells, such as red blood cells. Using a rapid deformation based microfluidic system, loading of red blood cells with macromolecules of different sizes has been shown.
Massachusetts Institute Of Technology

Fused quinoline compunds as pi3k/mtor inhibitors

The present invention relates to the compounds of formula i, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of disease states associated with cancers associated with protein kinases, to their use as medicaments for use in the production of inhibition of mtor, pi3k reducing effects in warm¬blooded animals such as humans.. .
Advenchen Pharmaceuticals, Llc

Hemolysis-free blood plasma separation

A simple and robust on-chip blood plasma separation device is provided. The device is configured to integrate with downstream detection modules and provides sample-to-answer microfluidic poc diagnostics devices..
The Regents Of The University Of California

Nanosecond pulsed electric fields cause melanomas to self-destruct

Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nspefs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nspefs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop.
Old Dominion University Research Foundation

Insulin delivery methods, systems and devices

A method of insulin delivery, the method may include obtaining one or more blood glucose readings of a user, and, based on the blood glucose readings, generating a set of insulin delivery actions that may include delivery of a baseline basal rate or predefined variations of the baseline basal rate. The method may also include monitoring previous insulin delivery actions to the user to determine whether the previous insulin delivery actions include insulin beyond a threshold amount, where the previous insulin delivery actions may include delivery of the baseline basal rate or predefined variations of the baseline basal rate, and, based on the previous insulin delivery actions including insulin beyond the threshold amount, adjusting the set of insulin delivery actions..
Bigfoot Biomedical, Inc.

Insulin delivery methods, systems and devices

Methods of insulin delivery may include obtaining one or more blood glucose readings from a flash glucose monitor, where the blood glucose readings may be obtained in response to a user invocation of the flash glucose monitor. The method may also include generating multiple insulin delivery profiles of insulin delivery actions over multiple diurnal time segments based on the one or more blood glucose readings.
Bigfoot Biomedical, Inc.

Percutaneous driveline anchor devices and methods of use

Systems, methods, and devices for securing a driveline to a portion of skin are disclosed herein. The driveline can connect an external controller to an implantable blood pump.
Tc1 Llc

Pump or rotary cutter for operation in a fluid

The invention relates to a fluid pump or rotary cutter having at least one first element (9′″, 10′″) which can be brought from a transport state into an operating state by changing at least one mechanical property. Such a pump can, for example, be a blood pump for the medical, microinvasive area.
Ecp Entwicklungsgesellschaft Mbh

Driveline bone anchors and methods of use

Systems, methods, and devices for securing a driveline to a bone are disclosed herein. The driveline can connect an external controller to an implantable blood pump.
Tc1 Llc

Glycopolysialylation of non-blood coagulation proteins

A water soluble polymer, in particular polysialic acid (psa) or a modified psa (mpsa), is conjugated to an oxidized carbohydrate moiety of a glycoprotein other than a blood coagulation protein or to a ganglioside or drug delivery system by contacting the oxidized carbohydrate moiety with the water soluble polymer, wherein said water soluble polymer contains an aminooxy group and an oxime linkage is formed between the oxidized carbohydrate moiety and the aminooxy group on the water soluble polymer or wherein said water soluble polymer contains a hydrazide group and a hydrazone linkage is formed between the oxidized carbohydrate moiety and the hydrazide group on the water soluble polymer. Conjugates of aminooxy- or hydrazide-water soluble polymer, such as psa and mpsa, are thus obtained in which the psa or mpsa is attached via a carbohydrate moiety..
Baxalta Gmbh

Methods for treating metabolic disorders using fgf

The method provides methods and compositions for treating metabolic disorders such as impaired glucose tolerance, elevated blood glucose, insulin resistance, dyslipidemia, obesity, and fatty liver.. .
Salk Institute For Biological Studies

Method of treating low blood pressure

A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of angiotensin ii, or ang ii, to the patient..
The George Washington University A Congressionally Chartered Not-for Profit Corporation

Ang-(1-7) and derivative oligopeptides for the treatment of traumatic brain injury and other cognitive impairments

The present invention provides oligopeptides, in particular, ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/or traumatic brain injury..
Arizona Board Of Regents On Behalf Of The University Of Arizona

Compositions comprising phoenix dactylifera and methods of prevention and treatment using thereof

The present invention relates to compositions comprising: phoenix dactylifera fruit flesh; or phoenix dactylifera fruit skin; or phoenix dactylifera fruit extract; or phoenix dactylifera seed extract; or phoenix dactylifera stem cells extract; or phoenix dactylifera nanoparticles, or combination thereof as active ingredients and physiologically acceptable additives, carriers or diluents. The present invention also relates to methods of using said compositions in treating and/or preventing diseases or conditions, including but not limited to, gastrointestinal disorders, hyperbilirubinemia, skin disorders, wrinkles, scars, wounds, hair disorders, oncological diseases, endocrinological disorders, immune disorders, respiratory diseases, nutrition disorders, liver diseases, kidney diseases, poisoning, dental problems, infertility, diaper rash, neurological diseases, bone diseases, blood diseases, psychiatric diseases, diabetic foot ulcer, gynecological diseases, premenstrual syndrome, pain management, infections, labor induction and delivery management.

Method and the use to improve oral absorption of nicotinamide and nicotinamide riboside

The present invention provides methods to improve oral absorption of nicotinamide or nicotinamide riboside or both nicotinamide and nicotinamide riboside via gastric (stomach) uptake or via intestinal uptake into the portal circulation blood. Mixtures of nicotinamide or nicotinamide riboside or both nicotinamide and nicotinamide riboside with botanical sources of flavonoids such as hibiscus sabdariffa dried calyces or cocoa powder or aronia berries are prepared.
Better Standing Company Inc.

Optimizing mifepristone levels for cushing's patients

The present invention provides a method for optimizing levels of mifepristone in a patient suffering from cushing's syndrome. The method comprises the steps of treating the patient with seven or more daily doses of mifepristone over a period of seven or more days; testing the serum levels of the patient to determine whether the blood levels of mifepristone are greater than 1631 ng/ml; and adjusting the daily dose of the patient to achieve mifepristone blood levels greater than 1631 ng/ml..
Corcept Therapeutics, Inc.

Methods of treating neurodegenerative diseases using indane acetic acid derivatives which penetrate the blood brain barrier

This invention describes the use of indane acetic acid derivatives which are dual ppar delta/gamma agonists, and which penetrate the blood brain barrier and achieve effective brain to plasma drug levels at non-toxic doses, for the treatment of neurodegenerative diseases including one or more of the following: alzheimer's disease (ad); huntington's disease (hd); parkinson's disease (pd); amyotrophic lateral sclerosis (als); frontal temporal dementia (ftd); corticobasal degeneration (cbd); progressive supranuclear palsey (psp); dementia with lewy bodies (dlb); or multiple sclerosis (ms).. .
Dara Biosciences, Inc.

Stent apparatus and treatment methods

There is disclosed a method of treating hypoxia in tissue of a blood vessel, the method comprising placing a stent in the vessel, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall. There is disclosed a method of treating a subject with diabetic atherosclerosis, the method comprising placing a stent in a blood vessel of the subject, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall..
Veryan Medical Limited

Endovascular implant

A plaque tack can be used for holding plaque against blood vessel walls such as in treating atherosclerotic occlusive disease. The plaque tack can be formed as a thin, annular band for holding loose plaque under a spring or other expansion force against a blood vessel wall.
Intact Vascular, Inc.

Endovascular implant

A plaque tack can be used for holding plaque against blood vessel walls such as in treating atherosclerotic occlusive disease. The plaque tack can be formed as a thin, annular band for holding loose plaque under a spring or other expansion force against a blood vessel wall.
Intact Vascular, Inc.

Endovascular implant

A plaque tack can be used for holding plaque against blood vessel walls such as in treating atherosclerotic occlusive disease. The plaque tack can be formed as a thin, annular band for holding loose plaque under a spring or other expansion force against a blood vessel wall.
Intact Vascular, Inc.

Method and segmentation of blood vessels

A method for segmentation of blood vessels is disclosed. The method comprises acquiring a plurality of images representing axial slices through a region of interest, defining a fascia layer between a muscular region and a subcutaneous region by defining a boundary between high intensity images and low intensity images, and determining a landmark of the blood vessel.
Instituto De Engenharia De Sistemas E Computadores, Tecnologia E Ciência

Apparatus and use for an adjustable radial and ulnar compression wristband

An adjustable radial and ulnar vascular compression wristband and its method of use assists in achieving partial or full occlusion of a blood vessel to achieve patent hemostasis when applied to a patient's wrist during or following a medical procedure. At least two adjustably inflatable non-adjacent balloons on the wristband apply preferential compression to portions of the circumference of the wrist, including in particular those portions overlying the ulnar and radial arteries..
Semler Technologies, Inc.

Closure device for sealing percutaneous opening in a vessel

Closure systems, kits and methods for sealing a percutaneous puncture or other opening in a blood vessel wall, body cavity or biopsy tract are disclosed. A closure system can comprise an implant assembly, a delivery assembly, and an introducer sheath.
Teleflex Innovations S.à.r.l.

Fiber-optic realshape sensor for enhanced dopper measurement display

A doppler ultrasound system for executing doppler ultrasound tests. The doppler ultrasound system employs an ultrasound probe (40), a vessel fors sensor (20) and a doppler ultrasound controller (60).
Koninklijke Philips N.v.

Method, image processing device, computer program and electronically readable data carrier for reducing vessel overlap artifacts in a four-dimensional angiography data set

Vessel overlap artifacts are reduced in a four-dimensional angiography data set a blood vessel system of a patient with a contrast medium. A three-dimensional vessel data set of the blood vessel system is reconstructed from two-dimensional projection images of digital subtraction angiography showing the blood vessel system, determined by multiplicative back projection of the projection images into the vessel data set or a base data set of the four-dimensional angiography data set derived vessel data set.

Processing biological data

An apparatus for determining data pertaining to the heart rate, respiratory rate, and/or blood pressure of a human subject based on pulse waveform analysis is disclosed. The apparatus comprises a control unit and a sensor unit configured for providing pulse wave data representative of a heartbeat of a subject.
Preventicus Gmbh

System and method to control temperature

Disclosed is a device and method of controlling blood flow to a selected area. Also disclosed is a system and method to regulate a temperature at a selected location.

Smart menstrual cup and measuring menstrual blood using smart menstrual cup

An embodiment of the present invention provides a smart menstrual cup comprising: a storage unit, a side of which is open so as to receive menstrual blood in at least one inner space thereof; a measuring unit for measuring menstrual blood received in the storage unit; and a control unit for generating a signal on the basis of measurement information from the measuring unit or processing information obtained on the basis of the measurement information.. .
Loon Lab Inc.

Flexible analyte sensors

Flexible analyte sensors are provided. Flexible analyte sensors may be flexible continuous analyte sensors that facilitate continuous monitoring of an analyte such as blood glucose.
Dexcom, Inc.

Heating oximeter

A heating oximeter includes a heat insulation portion, a heat generation portion including a resistor generating heat by energization, a first temperature detector including a first temperature sensor detecting a temperature of the heat generation portion, an oxygen saturation acquisition assembly including light emitting elements and a light receiving element, and acquiring oxygen saturation in blood optically, and a third temperature detector including a third temperature sensor detecting a temperature of a living body. The heating oximeter is provided by stacking the third temperature detector, the oxygen saturation acquisition assembly, the first temperature detector, the heat generation portion, and the heat insulation portion in this order..
Murata Manufacturing Co., Ltd.

System and contactless blood pressure determination

A system and method for contactless blood pressure determination. The method includes: receiving a captured image sequence; determining, using a trained hemoglobin concentration (hc) changes machine learning model, bit values from a set of bitplanes in the captured image sequence that represent the hc changes of the subject; determining a blood flow data signal; extracting one or more domain knowledge signals associated with the determination of blood pressure; building a trained blood pressure machine learning model with a blood pressure training set, the blood pressure training set including the blood flow data signal of the one or more predetermined rois and the one or more domain knowledge signals; determining, using the blood pressure machine learning model trained with a blood pressure training set, an estimation of blood pressure; and outputting the determination of blood pressure..
Nuralogix Corporation

Pulse oximetry sensors and methods

Methods and systems are provided for a nasal pulse oximetry probe configured to measure blood originating from the internal carotid artery. One example system includes a light emitter and a light detector coupled to a substrate and an attachment mechanism configured to couple the nasal pulse oximetry probe to a nose of a patient, the light emitter and light detector positioned on opposite sides of the nose at the root of the nasal bridge..
General Electric Company

System and camera-based heart rate tracking

A system and method for camera-based heart rate tracking. The method includes: determining bit values from a set of bitplanes in a captured image sequence that represent the hc changes; determining a facial blood flow data signal for each of a plurality of predetermined regions of interest (rois) of the subject captured by the images based on the hc changes; applying a band-pass filter of a passband approximating the heart rate to each of the blood flow data signals; applying a hilbert transform to each of the blood flow data signals; adjusting the blood flow data signals from revolving phase-angles into linear phase segments; determining an instantaneous heart rate for each the blood flow data signals; applying a weighting to each of the instantaneous heart rates; and averaging the weighted instantaneous heart rates..
Nuralogix Corporation

Non-invasive blood pressure measurement using pulse wave velocity

A method and apparatus to non-invasively measure instantaneous blood pressure using pulse wave velocity are disclosed. A measurement component is affixed to a patient proximate to a blood vessel.
Stryker Corporation

Device for calculating systolic blood pressure using pulse transit time and method therefor

A method for calculating a systolic blood pressure includes receiving data regarding pulse transit time (ptt) and a systolic blood pressure (sbp) of a patient group, extracting a correlation between parameters (a, y0) by analyzing results obtained by applying the data regarding the pulse transit time (ptt) and the systolic blood pressure (sbp) of the patient group to a ptt-sbp (pulse transit time-systolic blood pressure) relationship (sbp=a*ptt−1+y0), receiving data regarding a first pulse transit time (ptt) and a systolic blood pressure (sbp) of a measurement subject, and acquiring unique parameter values (a, y0) of the measurement subject by applying the correlation between the parameters (a, y0) and the data regarding the first pulse transit time (ptt) and the systolic blood pressure (sbp) of the measurement subject to the ptt-sbp relationship.. .
University Of Ulsan Foundation For Industry Cooperation

Blood pressure analyzing apparatus, blood pressure measuring apparatus, and blood pressure analyzing method

A blood pressure analyzing apparatus includes: a blood pressure variation determiner determining whether first blood pressure information varies a threshold or more from second blood pressure information or not, the first blood pressure information corresponding to an arbitrary beat, the second blood pressure information corresponding to a previous beat to the arbitrary beat; a blood pressure variation cause determiner determining whether a blood pressure variation is caused by the move of the wrist or by another reason than the move of the wrist, based on, wrist move information detected in a detection period of a pulse wave serving as a calculation source of the first blood pressure information, when it is determined that the first blood pressure information varies the threshold or more from the second blood pressure information; and a recording controller recording a determination result and the first blood pressure information in association with each other.. .
Omron Healthcare Co., Ltd.

Blood pressure measurement device

A pulse wave sensor is to detect a pulse wave signal from a measurement target finger, which is a part of fingers of a subject. A placement table is to enable a palm of the subject to be placed thereon.
A&d Company, Limited

Physiological signal measurement device and blood oxygen concentration algorithm applied therein

A physiological signal measurement device includes a shell, a pair of induction sheets mounted to the shell, and a circuit board assembly mounted in the shell. The circuit board assembly includes a microprocessor, a photoplethysmography sensor electrically connected with the microprocessor, and an electrocardio signal sensor.
Cheng Uei Precision Industry Co., Ltd.

Blood pressure measurement method and blood pressure measurement device applying the same

A blood pressure measurement method includes specific steps. Sample and store photoplethysmography signals and electrocardiosignals.
Cheng Uei Precision Industry Co., Ltd.

Functional composition for improvement and prevention of estrogen deficiency in menopausal women

The present invention relates to a food composition for improvement and prevention of estrogen deficiency, the composition containing a thistle extract or a thistle and thyme complex extract as an active ingredient. The present invention has advantages of alleviating estrogen deficiency in climacteric women and improving symptoms caused by estrogen deficiency, such as facial flushing, sweating, fatigue, anxiety, depression, memory impairment, insomnia, increased blood cholesterol, weight gain, and reduced bone density..
Famenity Co., Ltd.

Pet food product

The present invention relates to a composition comprising a mixture of blood and intestines. The invention also relates to a meat like chunk comprising such a composition and a moist pet food comprising such a meat like chunk.
Mars, Incorporated

Method and devices for flow occlusion during device exchanges

A method of reducing the risk of clinical sequelae to catheter induced vascular injuries may include introducing a guide wire into a vascular sheath residing in a blood vessel, proximally retracting the vascular sheath while leaving the wire in place, and observing indicia of the presence or absence of a vascular injury caused to the blood vessel by the vascular sheath or a procedural catheter previously advanced through the vascular sheath. If indicia of a vascular injury are observed, the method may further involve proximally retracting the guide wire to position the inflatable balloon adjacent the injury and inflating the balloon to reduce blood flow past the injury, while leaving the guide wire in place to provide subsequent access to the injury.
Lazzeri Societa Agricola A R.l.

Dynamic analysis apparatus and dynamic analysis system

A dynamic analysis apparatus may include a setting section which sets a target region in a lung region of a chest dynamic image; a conversion section which calculates a representative value of a pixel signal value in the target region, and converts the pixel signal value; an extraction section which extracts a pulmonary blood flow signal from the image; and a calculation section which calculates a change in the pulmonary blood flow signal, and calculates a feature amount regarding pulmonary blood flow. The setting section may determine a size of the target region based on a size of a body part other than a lung blood vessel, a movement amount of a body part other than the lung blood vessel or subject information of the chest dynamic image, the subject information regarding a subject of the radiation imaging, and the setting section may set the target region..
Konica Minolta, Inc.

Decentralized competitive arbitration using digital ledgering

Disclosed techniques enable arbitration of electronic competitions using digital ledgering. A digital competition arbitration platform is based on secure, trusted digital ledgering techniques.
Firstblood Technologies, Inc.

Methods and systems for metabolite and/or lipid-based detection of colorectal cancer and/or adenomatous polyps

Described herein are sets of metabolite and lipid (e.g., fatty acid) markers that can be used in the detection of early stage colorectal cancer and/or early development of adenomatous polyps. Presented herein are illustrative pathology-linked panels.
Universal Diagnostics, S.l.

Immunoassay for free vitamin d

Disclosed is the invention to conduct immuno-adsorption of free 25(oh) vitamin d from blood or blood components, notably serum or plasma, after which the absorbed material is measured. A fluoro-alkyl surfactant is used to enhance the solubility of vitamin d and allow the measurement of free vitamin d.
Future Diagnostics B.v.

Immature platelet enumeration systems and methods

Embodiments of the present invention encompass automated systems and methods for analyzing immature platelet parameters in an individual based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (dc) impedance, radiofrequency (rf) conductivity, and/or light measurement data obtained from the biological sample with an evaluation of immature platelet conditions in the individual..
Beckman Coulter, Inc.

Method of estimating blood volume

Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. The method and devices include the use of a rbc flocculant, such as polydadmac, and an approximate blood hematocrit for the type of animal, as well as a calculated rbc packing ratio corresponding to the collection device being used.
Hemodus Medical, Llc

Apparatus and separating and concentrating fluids containing multiple components

An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus.
Biomet Biologics, Llc

Clot mitigating probe for blood analyzing instrument

Aspects of the present disclosure include a titration probe that mitigate the occurrences of titration probe clots. A bar such as segment of music wire, is extended across the tip of a titration probe and attached at both ends to the titration probe.
Instrumentation Laboratory Company

Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity

Methods for determining the hematocrit of a blood sample, and devices and systems used in conjunction with the same. The hematocrit value can be determined on its own, and further, it can be further used to determine a concentration of an analyte in a sample.
Lifescan, Inc.

16s ribosomal rna universal primers and use thereof in microbiological analysis and diagnostics

The subject-matter of the invention is a pair of primers, a method of microbiological analysis of biomaterial, application of ngs sequencing method in microbiological diagnostics of blood and diganostics set. An innovative method of body fluids diagnosing from microbiological perspective i.e.
Uniwersytet Jagiellonski

Method and system for isolating adipose-derived stem cells

The present invention refers to a non-invasive method for isolating adipose-derived stem cells from adipose tissue by illuminating the adipose tissue with at least one laser having a wavelength of between 360 nm to 480 nm or between 800 nm to 2 pm for a predetermined time for dissociating fat cells and blood vessels of the adipose tissue to release intact stem cells from the adipose tissue while maintaining the viability of the stem cells. In the preferred embodiment, the adipose tissue is illuminated with pulsed near infra-red (nir) laser and a continuous wave (cw) diode blue laser.
Agency For Science, Technology And Research

Methods and compositions for treating ulcers

The present disclosure provides compositions and methods for treating or preventing ulcers in subjects having low red blood cell levels and/or hemoglobin levels (e.g, anemia). In some embodiments, the compositions of the disclosure may be used to treat or prevent ulcers associated with anemia..
Acceleron Pharma Inc.

Systems and methods for treatment of fluid overload

Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system.
White Swell Medical Ltd

Systems and methods for treatment of fluid overload

Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system.
White Swell Medical Ltd

Assist device for sclerosing treatment of varicose veins

Assist device (10) for sclerosing treatment of varicose veins, aimed at being partially inserted into a blood vessel (20), including a tubular element (11), which has at least three ways (13, 14, 15), at least two of which (13, 14) are connected to at least one related inflatable balloon element (12, 12′, 16) by at least one through hole (30, 31), and at least one remaining way (15) of said three ways (13, 14, 15) has at least one hole (32) for the passage of a sclerosing substance (17), aimed at reaching a wall (18) of said blood vessel (20), in which at least one (16) of said at least two balloon elements (12, 12′, 16) has an elongated shape extending toward at least another balloon element (12, 12′) and a volume comprised in the range of 30% to 99% of the space inside said blood vessel.. .
I-vasc S.r.l.

Catheter systems and packaged kits for dual layer guide tubes

A catheter-based/intravascular ablation (denervation) system includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic or/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable needle delivery system is formed with self-expanding materials and include structures, near the end portion of the needles, or using separate guide tubes.
Ablative Solutions, Inc.

Baloonless endotracheal tube

Endotracheal tubes with balloons (cuffed) deform the circulation of air by applying pressure on the walls of the trachea and cause numerous complications. In the endotracheal tube analyzed in the invention, the valve system in the form of flexible membrane is used instead of balloons, during each expiration, the pressure on the trachea wall is decreased and the disorder of getting blood occurring in the mucosa of the trachea was prevented.

Single use delivery device

The invention is a single use delivery device capable of delivery of an agent (e.g., vaccine, drug, medicament, etc.) in a controlled manner and without requiring specialized skill in administering delivery of such agent. The delivery device is configured to be filled on-site and in the field with a dose of an agent, while remaining sterile and preventing the potential for contamination during the filling process.

Single use delivery device having safety features

The invention is a single use delivery device capable of delivery of an agent (e.g., vaccine, drug, medicament, etc.) in a controlled manner and without requiring specialized skill in administering delivery of such agent. The delivery device is configured to be filled on-site and in the field with a dose of an agent, while remaining sterile and preventing the potential for contamination during the filling process.

Single use delivery device prefilled with a reconstitutable agent

The invention is a single use delivery device configured to enable reconstitution of a lyophilized agent (e.g., vaccine, drug, medicament, etc.) stored within for subsequent delivery of the reconstituted fluid agent to a patient in a controlled manner and without requiring specialized skill in reconstituting the agent or administering delivery of such agent. The delivery device is prefilled with an individual dose of a lyophilized agent and configured to be filled on-site and in the field with a dose of diluent for reconstitution of the lyophilized agent, while remaining sterile and preventing the potential for contamination during the filling process.

Fluid management system and methods

A hysteroscopic fluid management system includes a saline source with an electrolyte concentration, at least one pressure mechanism for circulating saline to and from a targeted site and through a filter having filter characteristics back to the source, and a controller. The controller provides a saline inflow in a first flow path to the site and a saline outflow in a second flow path from the site through the filter and back to the source at a controlled flow rate.
Boston Scientific Scimed, Inc.

Antithrombogenic hollow fiber membranes and filters

The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses..
Interface Biologics, Inc.

Process feature graphical elements for medical treatment user interfaces

Graphical user interfaces for use with extracorporeal blood treatment systems may include one or more process feature graphical elements. The process feature graphical elements may be moved automatically or manually by users to provide indications with respect to the process features associated with and represented by the process feature graphical elements..
Gambro Lundia Ab

Apparatus for determining a parameter indicative of the progress of an extracorporeal blood treatment

An apparatus for extracorporeal treatment of blood (1) comprising a treatment unit, a blood withdrawal line, a blood return line, a preparation line and a spent dialysate line. A control unit (10) is configured to calculate values of a parameter relating to treatment effectiveness based on measures of the conductivity in the spent dialysate line.
Gambro Lundia Ab

Treatment solution delivery in an extracorporeal blood treatment apparatus

Blood treatment apparatus and methods of using the same are described herein that include two or more intermediate containers located between a treatment solution source and a port through which the treatment solution is to be delivered with the blood treatment apparatus. The weight of the intermediate containers is measured and used to control the refilling and emptying of treatment solution in the intermediate containers..
Gambro Lundia Ab

Implantable intravascular ventricular assist device

The present disclosure provides intravascular ventricular assist devices for insertion into the vasculature of an individual to improve the overall blood flow of the individual. In many embodiments, the intravascular ventricular assist devices described herein provide an individual with an intravascular ventricular assist device that is sized and configured for insertion into an aortic root or pulmonary root such that its reduced size and placement provide the individual with an improved quality of life.

Printable morphogenetic phase-specific chitosan-calcium-polyphosphate scaffold for bone repair

This invention concerns a formula for the synthesis of a printable hybrid material, formed of carboxymethyl chitosan (cmc) and polyphosphate (polyp). Both polymers are linked together by calcium ions.

Nanoconjugates able to cross the blood-brain barrier

Polyvalent nanoconjugates address the critical challenges in therapeutic use. The single-entity, targeted therapeutic is able to cross the blood-brain barrier (bbb) and is thus effective in the treatment of central nervous system (cns) disorders.
Northwestern University

Products and methods for delivery of polynucleotides by adeno-associated virus for lysosomal storage disorders

The present invention relates to methods and materials useful for systemically delivering polynucleotides across the blood brain barrier using adeno-associated virus as a vector. For example, the present invention relates to methods and materials useful for systemically delivering α-n-acetylglucosamidinase polynucleotides to the central and peripheral nervous systems, as well as the somatic system.
Nationwide Children's Hospital, Inc

Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the gi tract. Many embodiments provide a swallowable device for delivering the agents.
Rani Therapeutics, Llc

Mutated fibroblast growth factor (fgf) 1 and methods of use

The present disclosure provides fgf1 mutant proteins, such as those having an n-terminal deletion, point mutation(s), or combinations thereof, which can reduce blood glucose in a mammal. Such mutant fgf1 proteins can be part of a chimeric protein that includes a β-klotho-binding protein, an fgfr1c-binding protein, a β-klotho-binding protein and a fgfr1c-binding protein, a c-terminal region from fgf19 or fgf21.
Salk Institute For Biological Studies

Angiotensin ii alone or in combination for the treatment of hypotension

The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin ii which is effective to raise the blood pressure of the subject to a mean arterial pressure (map) of about 65 mm hg or above, and which is effective to reduce the dose of the catecholamine required to maintain a map of about 65 mm hg to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.. .
The George Washington University A Congressionally Chartered Not-for-profit Corporation

Bioeffective krill oil compositions

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and/or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process.
Aker Biomarine Antarctic As

Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment

A method of generating an isolated population of cells comprising anti-third party cells having a central memory t-lymphocyte (tcm) phenotype, the cells being tolerance-inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) contacting peripheral blood mononuclear cells (pbmc) with a third party antigen or antigens in the presence of il-21 so as to allow enrichment of antigen reactive cells; and (b) culturing the cells resulting from step (a) in the presence of il-21, il-15 and il-7 in an antigen free environment so as to allow proliferation of cells comprising the central memory t-lymphocyte (tcm) phenotype..
Yeda Research And Development Co. Ltd.

Stem cell culture media and methods of enhancing cell survival

The invention provides improved methods for preparing hematopoietic cells for transplantation and the resulting improved hematopoietic cell compositions. The invention further relates to improved culture media and methods of culturing, processing, modulating, and expanding blood cell products for hematopoietic transplantation..
Fate Therapeutics, Inc.

Potassium-binding agents for treating hypertension and hyperkalemia

The present invention generally relates to methods of treating hypertension (htn) in patients in need thereof wherein the patient optionally further suffers from chronic kidney disease (ckd) or type ii diabetes mellitus (t2dm). The invention also relates to methods of treating hyperkalemia in a patient in need thereof, wherein the patient suffers from ckd, t2dm or htn and are optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (raas) agent.
Relypsa, Inc.

Gut anti-inflammatory agents for regulation of high blood glucose levels

A method of treating high blood glucose levels is disclosed. The method includes administering gut anti-inflammatory agents such as mesalamine (5-aminosalicylic acid), sulfasalazine, asacol, delzicol, pentasa, lialda, apriso, olsalazine, balsalazide and ged-0507-34, or pharmaceutically acceptable salts, solvates, or esters of any of the foregoing.
University Health Network

Compositions and methods using same for delivering agents into a target organ protected by a blood barrier

A method of delivering a pharmaceutical agent into a target organ protected by a blood barrier is provided. The method comprising administering to a subject in need thereof an amount of liposomes which comprise the pharmaceutical agent, the amount and the liposomes are selected such that the liposomes accumulate in cells of an immune system of the subject to thereby generate liposome loaded immune cells, the liposome loaded immune cells become activated and cross the blood barrier, and an effective amount of the pharmaceutical agent is released from the liposomes in the target organ of the subject..
Biorest Ltd.

Device and ablative cutting with helical tip

Catheter devices for ablation and removal of occlusions from blood vessels and methods of using the same are provided. Catheter devices are useful to ablate, cut, dislodge, and otherwise remove occlusions within a blood vessel that may limit or prevent proper circulation.
The Spectranetics Corporation

Devices and methods for treating vascular occlusion

Systems and methods for removal of thrombus from a blood vessel in a body of a patient are disclosed herein. The method can include: providing a thrombus extraction device including a proximal self-expanding member formed of a fenestrated structure, a substantially cylindrical portion formed of a net-like filament mesh structure having a proximal end coupled to a distal end of the fenestrated structure; advancing a catheter constraining the thrombus extraction device through a vascular thrombus, deploying the thrombus extraction device by stacking a portion of the net-like filament mesh structure outside of the catheter by distally advancing the self-expanding member until the self-expanding member is beyond a distal end of the catheter; retracting the self-expanding member to unstack the portion of the net-like filament mesh structure and to capture the portion of the thrombus; and withdrawing the thrombus extraction device from the body..
Inari Medical, Inc.

Hemostatic method

A hemostatic method is performed as follows: a) an at-puncture hemostatic pressure is applied to a puncture in a blood vessel via a main geometric side, and at least one off-puncture hemostatic pressure is applied to at least one position away from the puncture via at least one auxiliary geometric side, wherein the off-puncture hemostatic pressure acts on the blood vessel either directly or indirectly. B) during the hemostatic process, an ongoing flow velocity of the blood in the blood vessel is obtained and is reduced to lower than a normal flow velocity in the blood vessel by applying the at-puncture and off-puncture hemostatic pressures simultaneously, wherein the at-puncture and off-puncture hemostatic pressures are lower than a systolic pressure in the blood vessel..
Southern Taiwan University Of Science And Technology

Personalized tourniquet for intermittent vascular occlusion

An apparatus for intermittent vascular occlusion based on a personalized tourniquet pressure (ptp) includes a dual-purpose tourniquet cuff having an inflatable bladder, a sensor module having a pulsation sensor communicating pneumatically with the inflatable bladder for sensing and characterizing pressure pulsations indicative of a distal occlusion pressure (dop) to identify a minimum pressure at which penetration of blood past the cuff is stopped, a ptp estimator responsive to the pulsation sensor for producing an estimate of a ptp, wherein the estimate of the ptp is a function of the dop, an effector module communicating pneumatically with the inflatable bladder for maintaining pressure in the bladder near the ptp during a first time period and for maintaining pressure in the bladder near a second level of pressure during a second time period, and a controller selectively operating the inflatable bladder in conjunction with the sensor module and the effector module.. .
Western Clinical Engineering Ltd.

Control device of ultrasonic diagnostic apparatus, ultrasonic diagnostic apparatus, clutter component reducing method

A control device of an ultrasonic diagnostic apparatus includes a detector that detects a doppler signal from a reception signal based on a reflected ultrasonic wave reflected on an internal portion of a subject, and a clutter component reducer that acquires a frequency spectrum based on the doppler signal and reduces a clutter component from the acquired frequency spectrum based on symmetry of the clutter component which is distinguished from asymmetry of a blood flow component in the acquired frequency spectrum.. .
Konica Minolta, Inc.

Ultrasonic diagnostic device, image processing device, and image processing method

An ultrasonic diagnostic device includes an ultrasonic probe and processing circuitry. The probe conducts ultrasonic scanning on a three-dimensional area of a subject and receives a reflected wave from the subject.
Canon Medical Systems Corporation

Appliance

An appliance includes a belt that is worn by being wound around a wrist. The appliance includes: at least a first display region that is positioned in an area of the belt that corresponds to a volar-side surface or a radius-side surface of the wrist; and a second display region that is positioned in an area of the belt that corresponds to a back-side surface of the wrist.
Omron Healthcare Co., Ltd.

Container device for collecting, storing and processing blood or a blood compound

Container device (1) for collecting, storing and processing blood or a blood compound, which comprises a tube (10) with a connector (23) on its distal end (13), a piston set (30, 50) that can move through an interior space (14) of the tube (10), and a valve set (70, 90) preventing the flow of fluid through the distal opening (16) of the tube (10). The valve set (70, 90) is operable to allow the flow of the fluid through the distal opening (16).
Biotechnology Institute, I Mas D, S.l.

Method for spectrophotometric blood oxygenation monitoring

An apparatus and method for non-invasively determining a blood oxygen parameter value of a subject's tissue is provided. An embodiment of the method includes the steps of: a) providing a spectrophotometric sensor that includes a processing portion and a transducer, b) detecting at least a portion of transmitted light after passage through the subject's tissue and producing initial signal data from the detected light; and c) using the processing portion to: (i) determine a value representative of an attenuation of at least one wavelength of light detected; (ii) determine whether the representative attenuation value is outside a predefined range of attenuation values; and (iii) determine the blood oxygen parameter value using a first interrogation or an alternate interrogation setting..
Cas Medical Systems, Inc.

Device and determining analyte levels

Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device.
Dexcom, Inc.

Imaging system for diagnosing patient condition

A system and method of characterizing a blood vessel. An imaging modality is utilized to take an image of the blood vessel that is under a first stimulated condition and an image of the blood vessel is under a second stimulated condition.
General Electric Company

System and physiological parameter monitoring

The present disclosure relates to a device, method and system (100) for calculating, estimating, or monitoring the physiological parameters of a subject. At least one processor, when executing instructions, may perform one or more of the following operations: receiving a first signal representing a pulse wave relating to heart activity of a subject, receiving a plurality of second signals representing time-varying information on the pulse wave, determining a blood oxygen level of the subject based on the plurality of second signals, identifying a first feature in the first signal, identifying a second feature in one of the plurality of second signals, computing a pulse transit time based on a difference between the first feature and the second feature, calculating a blood pressure of the subject based on the pulse transit time..
Vita-course Technologies Co., Ltd.

Novel optical interferometric scanning detector for cardiovascular function monitoring

The object of the present invention is to disclose a novel optical miniaturized handheld medical device for convenient monitoring and/or data collection of detailed signals on human cardiovascular function. The implementation consists of a number of advanced technologies, including interferometric detection, phase controlled focusing beam steering, auto-tracking scheme and algorism, and integrated optical chip assembly to enhance the device's performance and miniaturization.
Omnisensing Photonics, Llc

Blood pressure measuring apparatus and physical feature information calculating method

A blood pressure measuring apparatus includes: a triaxial acceleration sensor; an information output section which outputs information for guiding an arm of the person on which the blood pressure measuring apparatus is worn, to a pair of a first posture and a second posture between which a position of the wrist is different; a posture determiner which determines that the arm has been in each of the pair of the postures, based on an output signal of the triaxial acceleration sensor after the output of the information; and a physical feature information calculator which calculates physical feature information of the person based on moving acceleration information detected by the triaxial acceleration sensor in a period between when the arm is in one of the pair of the postures and when the arm is in the other of the pair of the postures.. .
Omron Healthcare Co., Ltd.

Biological information measurement apparatus and biological information measurement method

A biological information measurement apparatus includes: a pressure sensor including a pressure detecting element; a pressing mechanism which presses the pressure sensor against an artery in a living body; a press controller which controls a pressing force of the pressing mechanism; a blood flow sensor; a blood flow information measurer which measures blood flow information based on output of the blood flow sensor; a pressing force decider which decides a first pressing force based on blood flow information measured during a pressing force control time period when the pressing force is changed in one direction, and information of a pressure pulse wave detected during the pressing force control time period; and a record controller which records a pressure pulse wave detected in a first state where the pressing force is controlled to the first pressing force, and blood flow information measured in the first state.. .
Osaka University

Detection of peripheral arterial disease

A system for screening for peripheral artery disease (pad), including a plurality of instruments for measuring presence of blood flow derived physiological parameters, a data collection unit attached to each one of the instruments for receiving signals from each one of the instruments, and a data analysis unit for determining a likelihood of presence of pad based, at least in part, on the received signals. Related apparatus and methods are also described..
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.

Information processing device, information processing method, and program

The present technology relates to an information processing device, an information processing method, and a program for enabling continuous measurement of information in a body. The information processing device includes: a light emitting unit that emits light of a predetermined wavelength; an imaging unit that captures reflected light from an object; an analysis unit that analyzes an image captured by the imaging unit; a storage unit that stores an analysis result analyzed by the analysis unit; a communication unit that transmits the analysis result stored in the storage unit to another device; and a battery unit that generates and stores power to supply electric power to each unit, and the information processing device is embedded in a body to operate.
Sony Semiconductor Solutions Corporation

Blood pressure and cardiac monitoring system and method thereof

A blood pressure and cardiac monitoring system includes a sensing assembly, processor, memory, communication interface, and any suitable computer implemented modules communicatively coupled to each other via a bus. The sensing assembly comprises a first, second, and third sensor.
Robert Bosch Gmbh

Blood treatment machine having electrical heartbeat analysis

A blood treatment machine includes a blood pump; an arterial line in fluid communication with the blood pump; a venous line; and a heartbeat evaluation system including (i) a first electrode coupled to the arterial line or to a patient, (ii) a second electrode coupled to the venous line, (iii) electronic circuitry communicating electrically with the first electrode and the second electrode to sense an electrical heartbeat signal generated by the patient, and (iv) signal processing configured to use the sensed heartbeat signal to calculate at least one of (a) heart rate, (b) respiration, (c) stroke volume, (d) cardiac output, or (e) central blood volume.. .
Suntory Flowers Limited

National University Corporation Yamagata Universit Y

. .

Multi-junctional bleeding simulator

The present invention, when used by a live actor, allows users to safely simulate hemorrhaging in some of the most challenging blood vessels in the most challenging anatomical locations such as the carotid artery, the axillary artery, and the inguinal artery. The present invention further provides the ability for users to safely perform hemorrhage control procedures, such as compression and ligation.

Method and analyzing blood

A blood analyzing method for detecting a short sample of blood in a suction tube, when blood is sucked by the suction tube constituting a blood analyzing apparatus, includes measuring a first blood parameter by using blood that is present in a first area of a blood analysis area, blood in the blood analysis area being used to analyze the blood in the suction tube, measuring a second blood parameter by using blood that is present in a second area of the blood analysis area, the second area being different from the first area, and detecting the short sample of blood based on the first blood parameter and the second blood parameter.. .
Nihon Kohden Corporation

Diagnostic test for alzheimer's disease based on identification of a proteolytic pathway

A method for detecting circulating levels of beta amyloid peptides in an individual by administration of one or more inhibitors of an extracellular proteolytic pathway in blood and detection of the beta amyloid peptides in the blood or a fraction thereof. An example of an inhibitor is an anticoagulant.
Health Research, Inc.

Diagnostic blood test for sarcoidosis

Sarcoidosis is a multisystem disease characterized by granulomatous inflammation in affected organs. The present invention discloses kits and a system for a blood test using mycobacterial catalase-peroxidase that has a high positive predictive value for confirming a diagnosis of sarcoidosis..

Cancer diagnostic

Disclosed is the use of latrophilin expression as a biomarker for the diagnosis of haematopoietic cell cancer in a subject, together with methods for diagnosis and a kit for the detection of latrophilin expression on white blood cells collected from a subject.. .
University Of Kent, School Of Pharmacy

Immunoassay test slide

An immunoassay test slide for use in a dry chemistry analytical instrument includes a slide housing or case formed from two matable sections—a slide cover piece and a slide bottom piece. The slide housing defines an interior cavity in which is situated a sheet-like porous carrier matrix.
Idexx Laboratories, Inc.

Sample analyzer and computer program product

A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed..
Sysmex Corporation

Test sensor with multiple sampling routes

An improved disposable electrochemical test sensor designed to facilitate sampling of fluid samples. It has a fluid chamber having a novel extra wide sampling entrance.
Changsha Sinocare Inc.

Systems and methods for multiplexed hemostasis test panels

The invention features a diagnostic platform utilizing t2 magnetic resonance to directly measure integrated reactions in whole blood samples such as clotting, fibrinogen, clot contraction, and fibrinolysis to provide a comprehensive assessment of hemostatic parameters on a single instrument in minutes. The methods of the invention can be performed with less than 1 ml of blood and minimal sample handling..
T2 Biosystems, Inc.

Compound optical flow cells and manufacture and use

An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells) in liquid suspensions. Preferably manufactured by assembling, aligning, and optically joining at least two elements made from transparent material, the improved flow cell has a seamless internal flow channel of preferably non-circular cross-section in a cylindrical first element through which prepared samples can be metered and an independent second element having an external envelope suited to acquisition of optical parameters from formed bodies in such suspensions, the second element being conforming and alignable to the first element so that non-axisymmetric refractive effects on optical characterizing parameters of formed bodies passing through the flow channel in the first element may be minimized before the two elements are optically joined and fixed in working spatial relationship.
Beckman Coulter, Inc.

Method to distinguish and analyze white blood cells in the presence of red blood cells

Method for distinguishing between red blood cells and white blood cells. The method includes obliquely illuminating the blood sample with light from at least two rotational angles and analyzing light side scattered from cells in the sample to provide accurate discrimination of white blood cell types based on the anisotropy of red blood cell side scatter as compared to more isotropic white blood cell side scatter..
Massachusetts Institute Of Technology

Red blood cell dynamics for administering treatment for iron-deficiency anemia

Methods for identifying patients with anemia, distinguishing thalassemia-trait anemia from iron-deficiency anemia, and identifying pre-anemic patients several weeks before anemia becomes clinically detectable. Also, methods for detecting blood doping in athletes and for optimizing therapy with erythropoiesis stimulating agents or iron supplementation.
The General Hospital Corporation

Methods for obtaining regulatory t cells and uses thereof

Disclosed is a method for obtaining a population of human treg cells including the steps of: (a) culturing a population of human monocytes with a medium including an amount of an interleukin-34 (il-34) polypeptide in order to obtain a population of immunosuppressive macrophages; (b) co-culturing a population of human peripheral blood mononuclear cells (pbmcs) and the population of immunosuppressive macrophages obtained at step (a).. .
Centre Hospitalier Universitaire De Nantes

Sanitation systems and components thereof having a slippery surface

The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces. Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as liquid b to repel a wide range of materials, referred to herein as object a (solid a or liquid a).
President And Fellows Of Harvard College

Method for suppressing blood coagulation reaction for which lox-1 is responsible

The present invention provides an anti-blood coagulant capable of selectively suppressing a pathological blood coagulation reaction without increasing the risk of major bleeding. The anti-blood coagulant in accordance with the present invention includes a binding inhibiting component that inhibits the binding of lox-1 to at least one of factor v and factor va..
National Cerebral And Cardiovascular Center

Compositions and methods for treatment of diseases

A method for treating or preventing laminitis is provided comprising administering to an ungulate a therapeutically or prophylactically effective amount of a camelid protease inhibitor. Typically the ungulate is a horse and the camelid protease inhibitor is an inhibitor of equine metalloproteinases and equine serine proteases.

Methods and compositions for increasing red blood cells

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.. .
Acceleron Pharma Inc.

Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators

Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.
Glaxosmithkline Llc

Leukocyte and microparticles fractionation using microfluidics

This invention relates to a method for separating blood cells comprising the steps of: (a) lysing red blood cells of a blood sample and diluting said sample; (b) providing a microfluidic device comprising a spiral-shaped flow channel having at least a first end and a second end, wherein said flow channel has two inlet ports at or near said first end and at least two outlet ports at or near said second end, wherein one of the two inlet ports is located at the inner wall of the spiral-shaped flow channel and the other inlet port is located at the outer wall of the spiral-shaped flow channel and at least one of the outlet ports is connected to a container allowing the storage of blood cells; (c) introducing the sample of step (a) into the inlet port located at the outer wall of the spiral-shaped flow channel and introducing a sheath fluid into the inlet port located at the inner wall of the spiral-shaped flow channel; (d) driving said sample and the sheath fluid through the spiral-shaped flow channel; and (e) recovering the blood cell in the at least one container connected to the at least one outlet port. The present invention also relates to coupling above described method of purifying neutrophils in the native state with a method for diagnosing diabetes or an inflammatory disease in a subject, which involves further investigation of neutrophils by determining their rolling speed, the neutrophil circularity (nc) index and/or the expression of markers, such as intracellular reactive oxygen species (ros), cd1 1 b or psgl-1..
Nanyang Technological University

In vitro epithelial models comprising lamina propria-derived cells

An in vitro microfluidic “organ-on-chip” is described herein that mimics the structure and at least one function of specific areas of the epithelial system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and the associated tissue specific epithelial cells and endothelial cells.
Emulate, Inc.

Microfluidic device for real-time clinical monitoring and quantitative assessment of whole blood coagulation

A microfluidic coagulation assessment device includes a plurality of microchannels, with a blood sample driven through the microchannels at a substantially constant flow rate. A controller is configured to, in combination with a timer and a pressure sensing device, determine a first pressure value (or flow value) at an initiation of flow, a first time (tpg) at which a second pressure value is about twice the determined first pressure value, and a second time (tpf) at which a third pressure value is about (1+e) times the determined first pressure value and establish a subject coagulation model predictive of channel occlusion therefrom..
President And Fellows Of Harvard College

Separation membrane for blood processing and blood processing device including the membrane

Wherein r1 is a hydrogen atom or a methyl group; r2 is a methyl group or an ethyl group; n is 2 to 6 and m is 1 to 3; p denotes the number of repetition; and a plurality of each of r1, r2, n, and m present in one molecule may be the same or different.. .

Centrifuge and system for bodily fluid sample

The invention relates generally to health tests and needs to examine bodily fluids such as blood. The invention comprises a centrifuge and system for a bodily fluid sample.
Medigoo Oy

Using emotional maps and dialog display technology to improve workout experiences

Systems, apparatuses and methods may provide for technology to improve a workout experience of a user by determining an emotional state of the user, identifying a workout route based on the emotional state of the user, and outputting the workout route via a user interface device. Additionally, determining the emotional state of the user may include inferring emotions from one or more sensor information or user speech information.
Intel Corporation

Patient-specific functional cranioplasty with integrated ultrasonic transmitter arrangement for neuromodulation and opening of the blood brain barrier

The invention relates to an ultrasonic transmitter arrangement (1) with a plurality of ultrasonic transmitters (2) arranged on the arrangement whose emittable ultrasonic waves are focused toward a common focus (3). The arrangement (1) is embodied as a cranial bone implant (4) that can be implanted in the cranial bones (5) of a person as a replacement for one or more parts of the cranial bone (5), with the common focus (3) of the entire arrangement being arranged in a defined region of the brain (6) in the implanted state..

Methods and systems for controlling blood pressure by controlling atrial pressure

Systems and methods for controlling blood pressure by controlling atrial pressure and atrial stretch are disclosed. In some embodiments, a stimulation circuit may be configured to deliver a stimulation pulse to at least one cardiac chamber of a heart of a patient, and at least one controller may be configured to execute delivery of one or more stimulation patterns of stimulation pulses to the at least one cardiac chamber, wherein at least one of the stimulation pulses stimulates the heart such that an atrial pressure resulting from atrial contraction of an atrium overlaps in time a passive pressure build-up of the atrium, such that an atrial pressure of the atrium resulting from the stimulation is a combination of the atrial pressure resulting from atrial contraction and the passive pressure build-up and is higher than an atrial pressure of the atrium would be without the stimulation, and such that the blood pressure of the patient is reduced..
Backbeat Medical, Inc.

Cardiac health monitoring systems and methods involving hypertension relief device(s) and/or features

Systems and methods involving hypertension monitoring and/or treatment device(s) are disclosed. According to implementations herein, various combination systems, devices and methods that provide therapy and/or monitoring capabilities of a person's blood pressure, incorporating a ppg/ecg integrated sensor within the handle of a hypothermia therapy device for persons with hypertension, are provided..
Physiocue, Inc.

Method and device for enhanced blood flow

A non-invasive method and device for promoting a localized change in a flow of blood through a blood vessel in a limb segment of a body by a series of electrically stimulated contractions of muscle tissue in the limb segment, the method including the steps of: (a) providing a device including: (i) first, second and third electrodes, each adapted to operatively contact the limb segment; (ii) a signal generator, operatively connected to the electrodes, adapted to produce a series of electrical impulses to the limb segment via the electrodes, and (iii) a control unit adapted to control the signal generator to produce the series of electrical impulses; (b) positioning the electrodes on the limb segment, wherein the first electrode is positioned on a lower end of the lower leg, the second electrode is positioned on the lower leg, and the third electrode is positioned on an upper end of the lower leg, whereby the first and third electrodes are disposed on opposite ends of the lower leg, and the second electrode and one of the first and third electrodes are disposed on a same end of the lower leg; (c) effecting a sequence of muscular contractions of the lower leg, by operations including: (i) applying a first electrical impulse between the electrodes on the same end of the lower leg to induce a first muscular contraction of a first portion of the tissue; and (ii) applying at least a second electrical impulse between the first and third electrodes to induce a longitudinal muscular contraction of a second portion of the muscular tissue; and (d) repeating operations (i) and (ii), to repeatedly induce the contractions, to effect the increased flow of blood.. .

Systems and methods for treatment of fluid overload

Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system.
White Swell Medical Ltd

Valved catheters including high flow rate catheters

A pressure activated two-way slit valve assembly is designed to be used in combination with, but not limited to, a high flow rate catheter to prevent accidental ingestion of air or loss of blood if the closure cap comes off during non-use of the catheter. In addition, the potential for occlusion of the esthete due to blood clots in the catheter and catheter related infection is substantially reduced.
Angiodynamics, Inc.

Oxygen biofeedback device and methods

Supplemental oxygen is used by millions of people each year in hospitals and at home. The device and methods described allow people on supplemental oxygen through a feedback loop to optimize their blood oxygen level by measuring oxygen and/or carbon dioxide and/or other related gases in the blood.

Extracorporeal ambulatory assist lung

An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment for pressurizing blood entering the pressurizing stator compartment from the blood flow inlet.
Mississippi State University

Human-shaped graphical element for medical treatment user interfaces

Graphical user interfaces for use with extracorporeal blood treatment systems may include a human-shaped graphical element and one or more process feature graphical elements. The human-shaped graphical element may be moved automatically or manually by users with respect to the process feature graphical elements to provide indications with respect to the process features corresponding to the human-shaped graphical element and the process feature graphical elements..
Gambro Lundia Ab

Apparatus for the non-invasive measurement of the blood flow

The present invention comprises an apparatus for the non-invasive measurement of the blood flow through a shunt of a patient, wherein the apparatus has at least one bandage which can be worn by the patient as well as a plurality of sensors which are arranged in or at the bandage, which are arranged in at least one multidimensional matrix and which are configured such that they create a multidimensional matrix of measured values of at least one parameter detected by the sensors.. .
Fresenius Medical Care Deutschland Gmbh

Filter element for blood processing filter, blood processing filter, and blood processing method

The present invention provides a filter element for a blood processing filter, comprising a nonwoven fabric, wherein the rebound strength per unit basis weight (g/m2) before steam heat treatment is 0.3 (n·m2/g) or larger.. .
Asahi Kasei Medical Co., Ltd.

Alert on a dialysis machine

A dialysis machine comprising: a first sensor for detecting motion of a patient; a second sensor for detecting a health condition of the patient; a processing module for: controlling dialysis functions of a dialysis treatment; receiving information related to a status of the dialysis treatment in which toxins are removed from blood of the patient; receiving, from the first sensor, information related to the motion of the patient; receiving, from the second sensor, information related to the health condition of the patient; and identifying an emergency condition based at least in part on the information related to the motion of the patient, the information related to the health condition of the patient, and the information related to the status of the dialysis treatment; and a transceiver for: in response to identifying an emergency condition, sending a notification that includes patient information to one or more remote entities.. .
Fresenius Medical Care Holdings, Inc.

Blood collection canister assembly

A blood collection canister assembly enables a user to collect and transfer blood and includes liner and lid assemblies. The liner assembly is formed from a flexible liner material and defines an inner liner space.
Ecomed Solutions Llc

Expansible cardiovascular stent with collagen covering membrane

Disclosed is an expansible cardiovascular stent with a collagen covering membrane, comprising a reticular and tubular stent (1) and a covering membrane attached to the reticular and tubular stent. The reticular and tubular stent (1) and the covering membrane both have a certain extensibility.
Dongguan Dianfu Product Design Co., Ltd.

Carrier for use in delivering drug, conjugate, composition comprising same, and administrating same

The present invention provides a vesicle, a conjugate, a composition comprising the vesicle or the conjugate, for use in delivering a drug to the brain, and a method for administering the same. The composition of the present invention is a composition for administration to a subject according to a dosing regimen, comprising a carrier for drug delivery, wherein the dosing regimen comprises administering the composition to a subject who has been fasted or caused to have hypoglycemia and inducing an increase in blood glucose level in the subject, and the carrier is modified at the outer surface thereof with a glut1 ligand..
National University Corporation Tokyo Medical And Dental University

Therapeutic compositions of alpha-l-iduronidase, iduronate-2-sulfatase, and alpha-galactosidase a and methods of use thereof

The present invention provides pharmaceutical compositions comprising an a blood brain barrier peptide and a human peptide, such as an alpha-l-iduronidase (idua) protein, an iduronate-2-sulfatase protein (ids) protein, or an a galactosidase a protein (α-gal a) protein. The invention further provides methods of use for treating mucopolysaccharidosis type i (mps i), including hurler syndrome, hurler-scheie syndrome and scheie syndrome; methods of use for treating hunter syndrome; and methods of use for treating fabry disease..
Alexion Pharmaceuticals, Inc.

Drug regimen for treatment of cerebral ischemia

Treatment of subjects experiencing cerebral ischemia is improved when the treatment employs a thrombolytic and an inhibitor against vascular endothelial growth factor receptor signal transduction (vegf-rst) at a reduced, low dosage compared to that used to treat cancer patients. The treatment is also improved to permit point-of-care use by formulating protein drugs for long term stability at room temperature, providing doses appropriate for the method, and by combining the therapeutic agents with a point-of-care diagnostic for blood brain barrier integrity..
Shimojani, Llc

Allogenic tumor cell vaccine

The described invention provides a tumor cell vaccine comprising genetically modified tumor cell line of a particular tumor type that stably expresses high levels of two or more immunomodulators. According to some embodiments, an immunogenic amount of the tumor cell line variants may be selected for concomitant expression of two or more of recombinant membrane expressed igg1, cd40l, tnf-alpha, as well as membrane and soluble forms of gm-csf, and flt-3l peptides that are effective to elicit an anti-tumor immune response compared to the parent unmodified tumor cell line as measured in vitro by a one-way mixed lymphocyte tumor reaction assay using human peripheral blood mononuclear cells and the genetically modified allogeneic cell vaccine candidate.
Alloplex Biotherapeutics

Modulation of factor xa inhibitor-mediated blood loss by partial and transient administration of antidote

The present disclosure provides unit dose formulations and methods to reduce, stop or prevent bleeding in a patient undergoing anticoagulant therapy with a factor xa inhibitor. The methods entail at least partial neutralization of the factor xa inhibitors the unit dose formulations and methods of the present disclosure can be effective even after actual bleeding has initiated..
Portola Pharmaceuticals, Inc.

Herbal topical composition for muscle and joint health, recovery from exertion, and for pain management

A topical liniment composition that boost muscle relaxation, increase blood flow, and increase cutaneous delivery of herbal extract that contains polyphenols derived from red chili, black pepper, cinnamon, and turmeric includes a quantity of castor-mineral oil-camphor solution, a quantity of eucalyptus oil, a quantity of clove oil, a quantity of peppermint oil, a quantity of frankincense oil, a quantity of herbal extract concentrate solution, and a quantity of castor oil. Aforementioned ingredients are heterogeneously mixed with each other to formulate the topical liniment composition at standard temperature and pressure (stp).

Use of fk506 for the treatment of pulmonary arterial hypertension

A method for reducing pulmonary hypertension in a mammal that employs fk506 is provided. In certain embodiments, the method comprises administering fk506 to a mammal having pulmonary arterial hypertension associated with defective mbpr2 signaling at a dosage sufficient to reduce blood pressure in the pulmonary artery of the mammal..
The Board Of Trustees Of The Leland Stanford Junior University

Therapeutic agent for dyslipidemia

The present invention addresses the problem of providing a pharmaceutical combination composition and drug combinations for the prevention and/or treatment of dyslipidemic conditions such as atherosclerosis, hypercholesterolemia, low hdl blood disease in mammals including humans. A pharmaceutical composition for the prevention and/or treatment of dyslipidemia, etc.
Kowa Company, Ltd.

Methods of treating hypertriglyceridemia

In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.. .
Amarin Pharmaceuticals Ireland Limited

Tripulse release stimulant formulations

A single dosage form that delivers a tripulse (i.e., three pulses) release profile is provided. The dosage form includes at least three dosage units inside the final dosage form.
Cingulate Therapeutics Llc

Rejuvenation of billions of eyelids and eyes

A system and method for preventing and reducing droopy and puffy eyelids and for preserving and restoring visual acuities and preventing and reducing presbyopia and visual losses. The system comprises an apparatus having diverse structures for modulating and controlling the circulations and volumes of blood and fluids in eyelids, eyes and surrounding soft tissues and a means for avoiding the compression and disruptions of the circulations and physiology of the corneas and lenses, networked repositories for predicting and extrapolating trends of developments of said conditions and the needs of utilizations of said system and networked machines for producing individual customized apparatuses for fitting said organs and tissues of individuals..

Expandable device for capturing regurgitant jet, volume, and force to effect ventricular function and remodeling

An implant system for capturing a regurgitant jet to effect preserving the atrioventricular pressure gradient and ventricular remodeling in a human heart including an expandable implant for positioning in the atrial/ventricular valve of the human heart and at least partially within the atrium and/or the ventricle, the expandable implant defining a first position for at least partially capturing the atrioventricular pressure gradient and regurgitant trans-valvular blood flow and associated driving forces during systole and a second position for steering flow from the atrium to the ventricle to enhance vorticular flow during diastole; a therapeutic apical base plate attachable to the apex of the heart; and a tethering conduit connected between the expandable implant and the therapeutic apical base plate assembly that transducts the energy and/or forces of captured regurgitant trans-valvular blood flow or atrioventricular pressure to the structures of the ventricle and the ventricular wall.. .
Harmony Development Group, Inc.

Orthopaedic or biologic support structure, methods of making and methods of use

A support 70 for use with tissue or bone is described, the support 70 having one or more spaced apart brace members 72, and at least one elongated linking member 80 for linking to the one or more spaced apart brace members 72. The support 70 may be provided in use in combination with a biologic glue, the biologic glue comprising a first portion containing stabilized blood product, and a second portion containing a growth factor, the first portion and the second portion comingled when or after the support is introduced to the tissue or bone in a subject in need thereof.
Buck Medical Research Ltd.

Catheter apparatuses for modulation of nerves in communication with pulmonary system and associated systems and methods

Devices and systems for the selective positioning of an intravascular neuromodulation device are disclosed herein. Such systems can include, for example, an elongated shaft and a therapeutic assembly carried by a distal portion of the elongated shaft.
Medtronic Ardian Luxembourg S.a.r.l.

Energy treatment instrument, treatment system, and controller

An energy treatment instrument includes a first grasping piece, and a second grasping piece which opens or closes relative to the first grasping piece and which grasps a blood vessel between the first grasping piece and the second grasping piece. In accordance with the kind of blood vessel grasped between the first grasping piece and the second grasping piece, an actuation state of the energy treatment instrument is switched between a first mode to coagulate a blood vessel of a circulatory system, and a second mode to coagulate a blood vessel of a pulmonary circulation in contrast to the first mode..
Olympus Corporation

Coaptive surgical sealing tool

A coaptive surgical sealing tool may be similar to an ordinary hemostat with long (50, 60, 70 or 80 mm) thin jaws for sliding into the liver parenchyma, without tearing the larger blood vessels. The jaws are spring loaded and are designed for uniform compression, and to avoid closing too quickly.
City Of Hope

Ablation applicator with a matrix filled with particles

An ablation applicator for an ablation device for ablating tissue of a blood vessel having a tubular body defining an inner lumen to which an ablation medium is conductable, a control mechanism for converting the tubular body between a passive operation mode for inserting the ablation applicator into the blood vessel and an active operation mode for ablating tissue of the blood vessel, and an ablation medium supply line for supplying the ablation medium to the inner lumen and positioned within the inner lumen and having a number of openings for passing the ablation medium from the ablation medium supply line to the inner lumen for thermally contacting the ablation medium with the tubular body wherein at least some of the openings are distributed along the ablation medium supply line with a predetermined spacing between neighboring openings. The ablation device can include a first temperature sensor arranged within the inner lumen and an ablation medium return line inside the tubular body made from a material that defines the active shape of the applicator..
Afreeze Gmbh

Flexible intra-vascular aneurysm treatment stent

An intra-vascular aneurysm-treatment stent and a method for lowering pressure within an aneurysm bubble in a blood vessel. A stent coil is insertable into a blood vessel, the coil made of a material sufficiently flexible to move around curves, loops, and corners in the blood vessel.

Systems and methods for acute treatment to limit intracerebral hemorrhage growth

A method for the hemostasis of perforating and bleeding vessel related to intracerebral hemorrhage (ich) includes navigating an occlusion device into a parent artery and then deploying the occlusive device to transiently occlude bleeding vessels to reduce blood flow and local blood pressure until hemostasis is achieved, while maintaining flow within the parent artery. Embodiments of the occlusion device include a catheter, an expandable member sized for insertion into the mid-cerebral artery (mca) and having a length sufficient to occlude at least one ostia of the lenticulostriate arteries (lsa), with a flow path for blood provided from a proximal side of the expandable member to a distal side of the expandable member, and a semi-permeable contacting member about the expandable member and adapted to be in contact with a wall of the mca adjacent the ostia, the semi-permeable member permitting a reduce flow of blood through the ostia..
Cerepeutics, Llc

Anti-migration surgical ligation clip

The present disclosure provides a surgical clip for ligating a blood vessel or tissue structure. The surgical clip includes a first leg member including a first inner surface and a first plurality of protrusions disposed on the first inner surfaces.
Nanova Biomaterials, Inc.

Device for connecting hollow organs, especially blood vessels, by surgery

A sleeve for enforcing the end of a hollow organ so that it can be connected with a further end of a hollow organ, the sleeve comprising a cylindrical shape and being configured to be pushed over the end of the hollow organ and for turning-over the end of the hollow organ projecting from the sleeve around an end of the sleeve, wherein the sleeve has an adjustable diameter.. .
King Faisal Specialist Hospital & Research Centre

Apparatus and k-edge based interior tomography image processing

Provided are an apparatus and method for k-edge based interior tomography image processing. The apparatus efficiently performs tomography image reconstruction by acquiring different material images using an energy-selective detector, such as a photon counting detector.
Rensselaer Polytechnic Institute

Method and device for diagnosis of breast disease

The present invention relates to a method and a device for diagnosis of breast disease and, more specifically, to an x-ray mammography device and method, which allow positions of an x-ray radiation field and a thermogram acquisition means to be controlled such that the center axis of the x-ray radiation field and a visual axis of the thermogram acquisition means are the same, so as to acquire each of a mammogram and a breast thermogram having the same center, and generates a fusion image so as to obtain a structural image and an image of a physiological change (body temperature and the activity of blood vessels) of breast tissue, thereby improving an early diagnosis and diagnosis ability for breast disease.. .
Industrial Education Cooperation Organization Deagu Health College

Systems and methods including a human-shaped graphical element

Graphical user interfaces for use with extracorporeal blood treatment systems may include a human-shaped graphical element and one or more process feature graphical elements. The human-shaped graphical element may be moved automatically or manually by users with respect to the process feature graphical elements to provide indications with respect to the process features corresponding to the human-shaped graphical element and the process feature graphical elements..
Gambro Lundia Ab

System for collecting blood samples from a patient, and corresponding sample collection device and pumps for extracting blood from a patient

A system for taking blood samples from a patient, including a peristaltic pump having a rotor with a moving surface and a fixed surface for lodging therebetween a flexible tube and a head member for attachment of a sample holder tube support member, and a blood sampling device including a needle holder having a tubular portion for supporting a hypodermic needle having a connection base, the needle holder including a conduit with an inlet and an outlet, where the inlet has the tubular portion, the sample holder tube support member, and the flexible tube having a first end in fluid communication with the needle holder and a second end in fluid communication with the support member.. .
Cliniclab S.l.

Portable clinical analysis system for hematocrit measurement

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof..
Abbott Point Of Care Inc.

Calibration of glucose monitoring sensor and/or insulin delivery system

Disclosed are methods, apparatuses, etc. For calibrating glucose monitoring sensors and/or insulin delivery systems.
Medtronic Minimed, Inc.

Non-invasive intracranial pressure monitoring system and method

A system which includes a first sensor placed proximate to a perfusion field of an artery receiving blood which emanates from the cranial cavity is configured to monitor pulsations of the artery receiving blood which emanates from the cranial cavity artery. A second sensor placed proximate to a perfusion field of an artery which does not receive blood emanating from the cranial cavity configured to monitor pulsations of the artery which does not receive blood emanating from the cranial cavity.
Vivonics, Inc.

Blood pressure monitor cuff, manufacturing the same, and blood pressure monitor

A blood pressure monitor cuff is formed by stacking an outer circumferential layer arranged on a side opposite to that of a measurement site and a fluid bladder arranged on the measurement site side. The outer circumferential layer and the fluid bladder are formed of an elastomer material.
Omron Healthcare Co., Ltd.

Automated fitted cuff blood pressure and arm circumference measuring device

A blood pressure device having a cylindrical drum cuff housing adapted to measure the circumference of either a right or left arm and administer a blood pressure test. The drum cuff housing is connected to a knuckle support assembly adapted to provide freedom of movement for postural positioning before and during the blood pressure test..
Higi Sh Llc

Blood pressure measurement system using force resistive sensor array

A novel and useful pressure sensor array incorporating sensor elements constructed from electrically conductive film as a substrate. Examples of commercially available electrically conductive (i.e.
Livemetric (medical) S.a.

Viscoelasticity characteristics acquisition device, viscoelasticity characteristics acquisition method, viscoelasticity characteristics acquisition program, and recording medium recording said program

A viscoelastic characteristics acquisition device is a device that acquires viscoelastic characteristics of a blood vessel of an inspection target, and includes a pulse wave acquisition unit that acquires a time waveform corresponding to a volume pulse wave of the inspection target, a spectrum acquisition unit that acquires a volume pulse wave spectrum by performing fourier transform on the time waveform, an input unit to which values corresponding to maximum blood pressure and minimum blood pressure of the inspection target are input, and an analysis unit that acquires the viscoelastic characteristics on the basis of the values corresponding to the maximum blood pressure and the minimum blood pressure and the volume pulse wave spectrum at a frequency equal to or higher than a frequency corresponding to the pulse of the inspection target.. .
Hamamatsu Photonics K.k.

Reliable estimation of pulse transit time in motion for cuffless blood pressure estimation

Apparatuses, systems, and methods described herein can enable reliable estimation of pulse transit time (ptt) for a user in motion for cuffless blood pressure estimation. In one embodiment, a method involves receiving an electrocardiographic (ecg) signal and a photoplethysmographic (ppg) signal and detecting r-wave peaks in the ecg signal.
Intel Corporation

System and providing user feeedback of blood pressure sensor placement and contact quality

A novel and useful system and method for generating user feedback related to the quality of the placement and contact of a blood pressure sensor on a user's body. The sensor is incorporated in a wearable blood pressure measurement device that is capable of analyzing and providing feedback regarding the quality of placement and contact of the pressure sensor array.
Livemetric (medical) S.a.

Blood pressure ratio calculation device, blood pressure ratio calculation method, blood pressure ratio calculation program, and recording medium recording said program

A blood pressure ratio calculation device is a device for calculating a maximum-minimum blood pressure ratio corresponding to a ratio between a maximum blood pressure value and a minimum blood pressure value of an inspection target, and includes an input unit for inputting a relative blood pressure waveform corresponding to temporal change in relative blood pressure of the inspection target, a spectrum generation unit for generating a relative blood pressure waveform spectrum by performing fourier transform on the relative blood pressure waveform, and an analysis unit for calculating the maximum-minimum blood pressure ratio on the basis of the relative blood pressure waveform spectrum.. .
Hamamatsu Photonics K.k.

Auxiliary device for blood pressure measurement and blood pressure measuring equipment

The present invention discloses an auxiliary device for blood pressure measurement, including an audio collection part, an image collection part, and a terminal device. The present invention further provides blood pressure measuring equipment.

Alarm system that processes both motion and vital signs using specific heuristic rules and thresholds

The invention provides a body-worn monitor that measures a patient's vital signs (e.g. Blood pressure, spo2, heart rate, respiratory rate, and temperature) while simultaneously characterizing their activity state (e.g.
Sotera Wireless, Inc.

Compositions and methods for attracting insects

Disclosed are compositions for attracting insects (e.g., harmful or troublesome insects such as blood-sucking and biting insects, ticks and mites) to an object (e.g., insect trap) or area (e.g., field, orchard). Also disclosed are methods for attracting insects involving treating (or exposing) the object or area with a composition containing compounds described herein (e.g., a pro-fragrance compound selected from the group consisting of an acetal, a ketal, hemiacetal and mixtures thereof, wherein at least one of a parent aldehyde, ketone, or alcohol of the pro-fragrance acetal or ketal is a fragrance compound), and optionally a carrier or carrier material..
The United States Of America, As Represented By The Secretary Of Agriculture

Injectable preserving medium for preserving cells from placental blood, from bone marrow and from peripheral blood

The present invention relates to a solution for the preservation of cells from placental blood, from bone marrow and from peripheral blood. .
Centre National De La Rescherche Scientifique

Systems and methods for the treatment of aneurysms

Systems and method for treating aneurysms are provided which utilize formulations that form polymer foams in situ. The formulations generally have a buoyancy greater than or less than blood, and either float to the top of the aneurysm and foam from the top down or sink to the bottom and foam from the bottom up..
Sunglory Beheer B.v.

Low molecular weight polyethylene glycol drug conjugates having improved drug biological activity

Provided are polyethylene glycol drug conjugates of general formula (i), (ii) or (iii) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules.
Sunglory Beheer B.v.

Intravascular devices and delivery systems and uses thereof

In general, the invention features an intravascular device, a delivery system, and methods for filtering or deflecting emboli or other large objects from entering a protected secondary vessel or vessels the intravascular device of the invention may prevent passage of a particle in a blood vessel from passing through a filter supported by a frame, upper and lower stabilizers, and a wire. The wire may be used to stabilize the device upon its deployment and installation within a blood vessel.
Sunglory Beheer B.v.

Interactive intravascular procedure training and associated devices, systems, and methods

Devices, systems, and methods of intravascular procedure training are provided. In some instances, the method includes outputting, from a computing device to a display device in communication with the computing device, a first visual representation of a blood vessel; determining, using the computing device, a first course of action based on the first visual representation of the blood vessel; receiving, at an input device in communication with the computing device, a user input associated with a second course of action; comparing, using the computing device, the first and second courses of action; and outputting, from the computing device to the display, a comparison of the first and second courses of action.
Koninklijke Philips N.v.

Method and determining biometric indicators using multiple fluorescent markers

Disclosed are methods for determining biometric indicators such as plasma volume, hematocrit and glomerular filtration rate, in mammalian subjects such as humans. The methods utilize a plurality of fluorescent tags having distinct fluorescent characteristics, which may be associated with a single static molecule, or wherein the static molecule is labeled with a fluorescent tag and a dynamic molecule is labeled with another fluorescent tag.
Pharmacophotonics, Inc. D/b/a Fast Biomedical

Intergrin alpha v beta 6 for diagnosis/prognosis of colorectal carcinoma

The invention relates to a method for diagnosis of colorectal carcinoma in a patient, including detecting, in a blood sample obtained from said patient, an indicator protein selected from integrin subunit alpha(v) and integrin subunit beta(6) or their heterodimer.. .
Universitat Zurich

Monocyte integrin based microfluidic assay for evaluating coronary diseases

A diagnostic system for assessing cardiovascular health is provided that incorporates a microfluidic platform and sensors that capture inflammatory monocytes. The portable microfluidic platform shears activated monocytes in a small volume of blood (˜50 μl) over a glass substrate that mimics the stress and molecular constituents of an inflamed artery.
The Regents Of The University Of California

Measuring frequency of pathogen-specific t cells in peripheral blood

A method for detecting and quantifying of the frequency of t cells to multiple antigenic peptide epitopes comprising: measuring intracellular ca2+ signaling in individual t cells that are labeled with ca2+ sensitive fluorophore; wherein said t cells are placed on the glass bottom of a well-covered with antibodies or other capturing proteins specific for non-stimulatory t cells' surface receptors and wherein a peptide antigens are injected into the well and the peptide binds to mhc molecules on the t-cell surface, wherein an increase in the intracellular concentration of ca2+ in responding t cells leads to rise in intracellular fluorescence that is detected by fluorescent microscope and wherein the response rate of said detected fluorescence can be utilized to determine the quantity of responding t cells and the efficiency of said cells.. .
Thomas Jefferson University

Point of care sepsis assay device and method

Disclosed is a point of care sepsis assay comprising a disposable assay cartridge with a sample inlet for a blood sample, a filter to isolate blood plasma, a source of multivalent cations to cause a turbidity change in the plasma sample and a transparent window to measure the change in turbidity and the use of said assay in the diagnosis of sepsis.. .
Sepsis Limited

Allogeneic autophagosome-enriched composition for the treatment of disease

A method is presented for screening cells that produce allogeneic autophagosome enriched compositions able to induce expression of a selective marker on a subpopulation of peripheral blood mononuclear cells, the method comprising contacting a cell with a proteasome inhibitor, contacting the cell with a lysosome inhibitor, harvesting the resulting autophagosomes, determining a molecular signature of the harvested autophagosomes, and selecting cells that divert one or more toll-like receptor agonist and/or one or more molecular chaperones to the harvested autophagosomes. By screening for cells that divert one or more toll-like receptor agonist and/or one or more molecular chaperones to the harvested autophagosomes, enriched populations of autophagosomes may be generated which may illicit a specific immune response against numerous cancer types.
Providence Health & Sevices-oregon

Method for diagnosing fibromyalgia using micrornas

Method of diagnosing fibromyalgia based on micrornas. The invention provides a method for the molecular diagnosis of fibromyalgia patients, based on the analysis of the possible alteration of the levels of specific micrornas in peripheral blood mononuclear cells.
Universidad CatÓlica De Valencia "san Vicente MÁrtir"

High-purity galactooligosaccharide compositions, preparations, and applications thereof

Provided is a method of preparing a high-purity galactooligosaccharide composition by fermentation of a low-purity galactooligosaccharide mixture with a yeast strain, kluyveromyces lactis atcc 8585. The high-purity galactooligosaccharide composition includes at least 99% of galactooligosaccharides selected from the group consisting of galactotriose, galactotetrose, galactooligosaccharides with five or more sugar units, and combinations thereof and lower than 1% of monosaccharides and disaccharides.
King-prebiotics Biotechnology (tw) Co., Ltd.

High-purity galactooligosaccharide compositions, preparations, and applications thereof

Provided is a method of preparing a high-purity galactooligosaccharide composition by fermentation of a low-purity galactooligosaccharide mixture with a yeast strain, kluyveromyces lactis atcc 8585. The high-purity galactooligosaccharide composition includes at least 99% of galactooligosaccharides selected from the group consisting of galactotriose, galactotetrose, galactooligosaccharides with five or more sugar units, and combinations thereof and lower than 1% of monosaccharides and disaccharides.
King-prebiotics Biotechnology (tw) Co., Ltd.

Magnetic nanostructure for detecting and isolating cell-free dna comprising cationic polymer and magnetic-nanoparticle-containing conductive polymer

Provided is a magnetic nanostructure for detecting and isolating cell-free dna (cfdna) that including a cationic polymer and a magnetic-nanoparticle-containing conductive polymer. The magnetic nanostructure for detecting and isolating cfdna according to the subject matter can significantly improve detection and extraction efficiencies of dna present in a urine, csf, blood plasma, or blood sample, and exhibits an enhanced sensitivity.
National Cancer Center

Cell composition depleted from tcrab and cd45ra positive cells

The invention is directed to a method for the preparation of a cell population from a sample originating from bone marrow or blood, comprising the steps a) dividing the sample into a first fraction containing 50 to 99% of the cells of the sample and a second fraction containing 50 to 1% of the cells of the sample, b) labeling the cells of the first fraction with a first marker against tcr alpha/beta, c) labeling the cells of the second fraction with a second marker against cd45ra, d) removing the labeled cells from the first and second fraction and combining the remaining cells to a cell population. Furthermore, the invention is directed to a cell composition and the use of the cell composition.
Miltenyi Biotec Gmbh

Fusion protein containing bdnf

Disclosed is a fusion protein containing a brain-derived neurotrophic factor (bdnf). The fusion protein is a fusion protein of bdnf and a specific range of human anti-transferrin receptor antibody, which makes bdnf administered into the blood able to pass through the blood-brain barrier..
Jcr Pharmaceuticals Co., Ltd.

Compounds suitable for treatment of haemophilia

The present invention relates to vwf compounds as well as compositions suitable for treatment of blood clotting diseases.. .
Novo Nordisk A/s

Method and device for detecting cellular targets in bodily sources using carbon nanotube thin film

A device and method detect cellular targets in a bodily source by utilizing a biofunctional pad comprised of a thin film of carbon nanotubes (cnt's). When antibodies are absorbed by the cnt's, cellular targets having markers matching the antibodies may be detected in a bodily source placed upon the biofunctional pad by measuring the conductivity of the thin film using conductive contacts electrically coupled to the thin film, as the binding of the receptors in the cellular targets to the antibodies changes the free energy in the thin film.
University Of Louisville Research Foundation, Inc.

Method for separating blood plasma and metering thereof

A capillary driven microfluidic device with blood plasma separation means that can be used to separate, meter and transfer a blood sample. The blood separation means can be arranged as a capillary pump by the configuration of a porous membrane and the microfluidic device..
Capitainer Ab

Blood vessel optical fiber guide wire

A blood vessel optical fiber guide wire includes at least one of optical fiber core wire, a wire wrapping layer and a hydrophilic coating capable of improving compatibility with body liquids and reducing the resistance. The optical fiber core wire is disposed in a core of the optical fiber guide wire.

Internal thoracic vein placement of a transmitter electrode for leadless stimulation of the heart

Implantable medical device systems and methods of use including an implantable first medical device having a lead with a transducer thereon and an implantable second medical device having a receiver for receiving energy emitted by the transducer. The lead may be placed in an internal thoracic vein, and other locations may be used as well.
Cardiac Pacemakers, Inc.

Method and the dialysis of blood

Apparatus for use in dialyzing a patient comprising a hemodialysis catheter comprising an elongated body having a proximal and a distal end, wherein the distal end terminates in a substantially planar distal end surface; first and second lumens extending from the proximal end to the distal end, wherein the lumens terminate on the distal end surface in first and second mouths, arranged in side-by-side configuration, and further wherein the lumens are separated by a septum; and first and second longitudinal slots formed in the distal end of the elongated body and communicating with the interiors of the lumens, the slots opening on the distal end surface; wherein the slots each have a length and a width, relative to the dimensions of the lumens and the rate of blood flow to be passed through the hemodialysis catheter, so as to minimize undesirable recirculation of dialyzed blood.. .
Medical Components, Inc.

Chamber for blood treatment system and method using same

A chamber is provided for a blood treatment system and has at least one space defined by a chamber wall, at least one blood inlet, and at least one inlet for a further fluid, which are connected with the space. Both the at least one blood inlet and the at least one inlet for the further fluid are formed on tube sections that protrude into the space of the chamber.
Fresenius Medical Care Deutschland Gmbh

Catheter pump with positioning brace

A catheter pump assembly is provided that includes an elongate body assembly, a shaft, and an impeller. The assembly has a proximal end, a distal end and at least one lumen extending therebetween.
Tc1 Llc

Composition for treating hyperlipidemia comprising oxyntomodulin derivative

The present invention relates to a composition for preventing or treating hyperlipidemia, fatty liver disease or arteriosclerosis, comprising an oxyntomodulin derivative as an active ingredient. The oxyntomodulin derivative has a high ability to activate glp-1 receptor and glucagon receptor compared to native oxyntomodulin and has the effects of reducing the blood total cholesterol, low-density cholesterol and triglyceride levels that were increased by high-fat diet, and increasing high-density cholesterol levels and the high-density cholesterol/low-density cholesterol ratio.
Hanmi Pharm, Co., Ltd

Therapeutic uses of elsiglutide

The invention relates to therapeutic uses of elsiglutide, particularly for protecting and stimulating bone marrow and peripheral blood cell type activity or immune-response in patients compromised due to the administration of chemotherapeutic agents. The invention further provides uses of elsiglutide to enhance the antitumor activity of cytotoxic chemotherapeutic agents and target specific biological agents..
Helsinn Healthcare Sa

Methods for prevention and treatment of acute renal injury

The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or exposure to a nephrotoxic agent, such as a radiocontrast dye.
Cornell University

Production and use of red blood cells

The present disclosure relates to the production of red blood cells from hematopoietic stem cells, by differentiating such cells in the presence of a protein that induces cell survival and proliferation.. .
Taiga Biotechnologies, Inc.

Inverted leaflet prosthetic valve

Prosthetic valve embodiments are described herein that include a frame and a valve member mounted within the frame. The valve members can have a plurality of leaflets that are affixed to one another along their inflow edges, with articulating edges projecting from the inflow edges in the outflow direction.
Edwards Lifesciences Corporation

Intravascular blood filter

Disclosed is a novel filter and delivery means. The device described within will not interfere with standard practice and tools used during standard surgical procedures and tools such as cannulas, clamps or dissection instruments including valve replacement sizing gages or other surgical procedures where the patient must be put on a heart-lung machine cross-clamping the aorta..
Claret Medical, Inc.

Aorticorenal ganglion detection

Devices and methods that regulate the innervation of the kidney by detection and modification of the aorticorenal ganglion. Devices for percutaneous detection and treatment of the aorticorenal ganglion via a blood vessel to modify renal sympathetic activity..

Energy treatment instrument, treatment system, and controller

An energy treatment instrument includes a first grasping piece, and a second grasping piece which opens or closes relative to the first grasping piece and which grasps a blood vessel between the first grasping piece and the second grasping piece. An actuation state of the energy treatment instrument is switched between a first mode to coagulate the blood vessel when a branch of the blood vessel is not present within a predetermined range from a position where the blood vessel is grasped, and a second mode to coagulate the blood vessel when the branch of the blood vessel is present within the predetermined range..
Olympus Corporation

Vascular graft securement apparatuses and related kits and methods

Some of the present apparatuses include a flexible vascular graft defining a lumen and a hub having a distal end con figured to penetrate a blood vessel, a proximal end, and a wall extending between the distal end and the proximal end that defines an interior passageway. In some apparatuses, the vascular graft is non-removably coupled to the hub, and the lumen of the vascular graft is in communication with the interior passageway of the hub.
Scott & White Healthcare

Devices and methods for reshaping blood vessels

Veins and other blood vessels may be reshaped by introducing an implant through the vessel walls with anchors positioned on opposite sides of the wall. The anchors typically include an elongate body having coils or other anchors formed therein.
Sano V Pte Ltd

Creating a vascular tree model

A method for vascular modeling is disclosed. The method, in some embodiments, comprises receiving a plurality of 2-d angiographic images of a portion of a vasculature of a subject, and processing the images to automatically detect 2-d features, for example, paths along vascular extents, which are projected into 3-d to determine homologous features among blood vessels.
Cathworks Ltd.

Blood vessel detection apparatus, magnetic resonance imaging apparatus and program

An mri apparatus comprises a image producing unit 101 for producing an image of a first body part containing a blood vessel; a defining unit 108 for defining a slice intersecting the image based on a reference position q within the first body part, the slice being defined so that an angle of the slice is changeable with respect to the blood vessel ve; a unit for obtaining an index vi for deciding whether or not the blood vessel ve is contained within the slice for each angle θ; and a determining unit 111 for determining an angle of the slice at which the blood vessel ve is contained in the slice based on the index vi.. .
General Electric Company

Blood sample optimization system and blood contaminant sequestration device and method

Blood sample optimization systems and methods are described that reduce or eliminate contaminates in collected blood samples, which in turn reduces or eliminates false positive readings in blood cultures or other testing of collected blood samples. A blood sample optimization system can include a blood sequestration device located between a patient needle and a sample needle.
Kurin, Inc.

Processing apparatus and processing method

A processing apparatus having a processor acquiring image data indicating oxygen saturation distribution inside an object by using signals derived from acoustic waves generated from a plurality of wavelengths of light. The processor acquires an oxygen saturation at a first position of a blood vessel of the object, generated by image reconstruction using signals, acquires a first correction amount to correct the oxygen saturation at the first position of the blood vessel, and acquires a second correction amount to correct the oxygen saturation in a second position of the object other than the first position, based on the first correction amount..
Canon Kabushiki Kaisha

Method and device for presenting st event in electrocardiogram

A method for presenting an st event in an electrocardiogram (ecg) comprises: drawing an amplitude trend graph of an st segment in the ecg; detecting an st event in the amplitude trend graph of the st segment; and marking the detected st event in the amplitude trend graph of the st segment. In the present invention, the st event is automatically detected and marked in the amplitude trend graph of the st segment, so that the st events are presented more intuitively, and the user can intuitively and quickly locate the st event in the amplitude trend graph of the st segment and quickly know a raised or depressed situation of the st event; the time of subsequent analysis and summary can be effectively reduced, and a blood supply state of the heart of the subject can be timely and quickly known..
Edan Instruments, Inc.

Fluid bladder, blood pressure measurement cuff, blood pressure monitor, and blood pressure measurement method

A fluid bladder has a first fluid bladder region that inflates due to receiving a supply of fluid and is contained in a portion of an outer circumferential surface of a measurement site in a lengthwise direction of a cuff, the portion corresponding to a first half surface, where an artery is. Also, the fluid bladder has an expansion region that is expanded due to an action from outside, and is contained at a portion of the outer circumferential surface of the measurement site that corresponds to a second half surface, in the lengthwise direction of the cuff.
Omron Healthcare Co., Ltd.

Touch-type blood pressure measurement apparatus and method

A touch-type blood pressure measurement apparatus is provided. The touch-type blood pressure measurement apparatus include: a touch sensor configured to generate a contact area signal when a finger of a user is in contact with the touch sensor; at least one photoplethysmogram (ppg) sensor configured to generate a ppg signal of the user while the finger is in contact with the touch sensor; a force sensor configured to generate a touch force signal of the finger in contact with the touch sensor; and a controller configured to obtain a blood pressure of the user based on the contact area signal, the ppg signal, and the touch force signal..
Samsung Electronics Co., Ltd.

Medical measuring device

A measuring device for the non-invasive measurement of physiological parameters is suited to detect and localize by way of self diagnosis diseases such as, for example, inflammations, tumors or arteriosclerosis. The measuring device includes at least one optical measuring unit, an evaluation unit processing the measuring signals, and a unit for the acquisition of local tissue parameters such as fat content, water content and/or blood perfusion.

Blood pressure measurement instrument, and korotkoff's sound recognition

A blood pressure measurement instrument includes: a cuff capable of being worn at a measured position on a body of a user, a pressure sensor, a sound sensor, a pressure regulator, and a processor. The pressure regulator is configured to regulate a pressure applied to the measured position by the cuff; the pressure sensor is configured to acquire the pressure applied to the measured position by the cuff during a period of time when the pressure is changed; the sound sensor is positioned between the cuff and the measured position in a measuring process and is configured to acquire blood flow sound at the measured position; and the processor is connected with the pressure sensor and the sound sensor and is configured to determine a blood pressure value of the user according to acquisition results of the pressure sensor and the sound sensor..
Boe Technology Group Co., Ltd.

Method to measure non-invasive blood pressure from patient sensor system

A system and method for enhancing the determination of the blood pressure of a patient is disclosed. The system includes a wireless blood pressure sensing device that obtains blood pressure data from the patient and wirelessly transmits the data to a host system.
General Electric Company

Method for producing blood chimeric animal

The present invention discloses a novel means capable of producing a blood chimeric animal in which a state of retaining blood cells originating in a heterologous animal, such as a human, at a high percentage is sustained for a long period of time, even in cases where a medium to large domestic animal is used as a recipient. The method for producing a non-human animal that retains blood cells originating in a heterologous animal, according to the present invention, comprises transplanting hematopoietic cells of a heterologous animal into a non-human animal, in which hematopoietic cells the function of a gene that acts on the hematopoietic system is modified.
The University Of Tokyo

Calla lily plant named 'bloody mary'

‘bloody mary’ is a new variety of calla lily plant having inflorescences with a red-colored spathe that produces 2-10 inflorescences per tuber. The height of the top of an inflorescence above the soil can reach up to 48 cm.
Sunglory Beheer B.v.

. .

Eye motion detection method, program, program storage medium, and eye motion detection device

Provided is a method to easily detect eye motions in the eye moving direction, which has resistance to a fluctuation in background light and to a displacement of the position of a camera. The method includes the steps of: detecting a white area of the eye from the eye area; determining a blood vessel image to be used for a template blood vessel image in the white area of the eye; detecting a nth blood vessel image, which matches the template blood vessel image; calculating a nth moving amount of the eye based on a difference between the reference position and the detection position of the nth blood vessel image, which matches the template blood vessel image; and calculating a nth rotation angle of the eye to detect eye motions in the information processing apparatus..

Blood vessel analysis apparatus, medical image diagnosis apparatus, and blood vessel analysis method

According to one embodiment, a structuring circuitry temporarily structures a dynamical model of analysis processing based on the time-series medical image. The identification circuitry identifies a latent variable of the dynamical model so that at least one of a prediction value of a blood vessel morphology and a prediction value of a bloodstream based on the temporarily structured dynamical model is in conformity with at least one of an observation value of the blood vessel morphology and an observation value of the bloodstream measured in advance.
Toshiba Medical Systems Corporation

Method and process for providing a subject-specific computational model used for treatment of cardiovascular diseases

A subject-specific simulation model of at least one component in the cardiovascular system for simulating blood flow and/or structural features. This simulation model can be used as a tool for cardiovascular diagnostic and/or treatment planning.
Sintef Tto As

Image processing apparatus and image processing method

An image processing apparatus determines an exceptional frame of a plurality of frames forming a moving image captured by an ophthalmic apparatus including an aberration correction device, and applies image processing of a blood vessel area for a frame, among the plurality of frames, which has not been determined as the exceptional frame.. .
Canon Kabushiki Kaisha

Rapid and sensitive forensic toxicology in post-mortem subjects using oral fluid testing

The present invention provides a rapid, sensitive method for forensic drug testing in a post-mortem subject using oral fluid collected from the post-mortem subject. The method comprises collecting a sample of oral fluid from a post-mortem subject, analyzing the oral fluid sample qualitatively to detect the presence of one or more non-naturally occurring drugs, analyzing the oral fluid sample quantitatively to determine concentration of the one or more non-naturally occurring drugs in the post-mortem subject, and identifying the one or more non-naturally occurring drugs in the post-mortem subject.

Bin1 expression as a marker of cancer

Provided are methods for screening a subject for cancer. The methods involve obtaining a blood sample from the subject and determining a level of bridging integrator 1 (bin1) isoforms comprising exon 12a in the sample.
Sarcotein Diagnostics, Llc

Systems and methods for assessing blood platelet function

A method carried out by a system configured to analyze blood. The method includes causing a ferromagnetic object to move in a chamber housing blood after clot initiation has been implicated.
Medtronic, Inc.

Composition for high stringency cell treatment and antigen retrieval

The present invention relates to a cell treatment composition for the permeabilization of fixed blood cells, to the use of said composition, to a method for the treatment of a biological sample comprising fixation of said sample and subsequently contacting said biological sample with said cell treatment composition. The invention further relates and to a kit comprising said cell treatment composition..
Beckman Coulter, Inc.

Allogeneic autophagosome-enriched composition for the treatment of disease

A method is presented for screening cells that produce allogeneic autophagosome enriched compositions able to induce expression of a selective marker on a subpopulation of peripheral blood mononuclear cells, the method comprising contacting a cell with a proteasome inhibitor, contacting the cell with a lysosome inhibitor, harvesting the resulting autophagosomes, determining a molecular signature of the harvested autophagosomes, and selecting cells that divert one or more toll-like receptor agonist and/or one or more molecular chaperones to the harvested autophagosomes. By screening for cells that divert one or more toll-like receptor agonist and/or one or more molecular chaperones to the harvested autophagosomes, enriched populations of autophagosomes may be generated which may illicit a specific immune response against numerous cancer types.
Providence Health & Sevices-oregon

Method and system for estimating whether a female is pregnant based on a blood sample

A method for estimating whether a female is pregnant, said method comprising measuring allele presences (d) for a plurality of genetic markers of at least one chromosome, different from the x and y chromosome, in a sample of cell-free dna from a potentially pregnant female; each allele presence representing the presence at a genetic marker of at least one of: a reference allele of maternal or foetal origin, and an alternative allele of maternal or foetal origin; based on said measured allele presences, determining a homozygous fraction (fho) thereof which is associated with purely homozygous genetic markers; and estimating whether the female is pregnant based on said fraction.. .
Multiplicom Nv

Dendritic cell generator

Devices, systems, and methods can be used for the automated production of dendritic cells (dc) from dendritic cell progenitors, such as monocytes obtained from peripheral blood. The invention makes it possible to obtain sufficient quantities of a subject's own dc for use in preparing and characterizing vaccines, for activating and characterizing the activation state of the subject's immune response, and to aid in preventing and/or treating cancer or infectious disease..
Northeastern University

Diblock copolymers and polynucleotide complexes thereof for delivery into cells

Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic ph, and a second block that has hydrophobic groups.
Phaserx, Inc.

Anti-human transferrin receptor antibody permeating blood-brain barrier

Disclosed are a means to convert compounds having physiological or pharmacological activity and unable to pass through the blood-brain barrier into a form that allows them to pass through the blood-brain barrier, and compounds converted thereby. The means is an anti-human transferrin receptor antibody and the converted compounds are molecular conjugates between physiologically active protein or pharmacologically active low-molecular-weight compounds and an anti-human transferrin receptor antibody..
Jcr Pharmaceuticals Co., Ltd.

Pharmaceutical composition for the prevention and treatment of cardiovascular disease comprising the peptide having the ability to inhibit angiotensin-1 converting enzyme as an active ingredient

The present invention relates to a peptide separated from the fraction of oyster enzyme hydrate displaying the ability of suppressing angiotensin converting enzyme (ace) and a pharmaceutical composition for the prevention and treatment of cardiovascular disease comprising the said peptide as an active ingredient. Particularly, the peptide separated from the fraction of the oyster enzyme hydrate of the present invention significantly inhibits ace activity, and thus brings blood pressure regulating effect and antihypertensive effect.
Industry-academic Cooperation Foundation Gyeongsang National University

Maleate salts of a quinazoline derivative useful as an antiangiogenic agent

The present invention relates to azd2171 maleate salt, to particular crystalline forms of azd2171 maleate salt, to processes for their preparation, to pharmaceutical compositions containing them as active ingredient, to their use in the manufacture of medicaments for use in the production of antiangiogenic and/or vascular permeability reducing effects in warm-blooded animals such as humans, and to their use in methods for the treatment of disease states associated with angiogenesis and/or increased vascular permeability.. .
Astrazeneca Ab

Device for pelvic limb blood flow

A structure including left and right footplates and weight shafts provided at left and right sides in a blood circulation exercise interlocking device, providing a pelvic limb blood circulation ankle interlocking device comprising a vertical supporter configured at the center of a lower plate of a main body in a vertical direction, left and right auxiliary vertical supporters configured to be parallel in a vertical direction at left and right sides of the vertical supporter, rotary shafts configured at the same position as the left and right auxiliary vertical supporters in a horizontal direction of the vertical supporter, left and right rotary bars configured at left and right sides of the rotary shaft to be coupled with a rotating device, weights made of heavy metals at the upper ends of the left and right rotary bars, and left and right footplates configured at left and right rotation lower ends.. .

Method for controlling a device for extracorporeal blood gas exchange, device for extracorporeal blood gas exchange, as well as control device for controlling a device for extracorporeal blood gas exchange

A method controls a device for extracorporeal blood gas exchange. The device has a membrane as a gas-liquid barrier between a bloodstream and a gas stream.
Drägerwerk Ag & Co. Kgaa

Treatment of cancer by manipulating the immune system

The present invention relates to the treatment of cancers. Specifically, the invention pertains to a method for the extracorporeal treatment of one or more body fluids (e.g., blood or cerebrospinal fluid, csf) in two stages characterized by removing a body fluid (e.g., blood or csf) from a living body diseased with a type of cancer, passing the body fluid through a first stage of applying a treatment to at least one antigen in the body fluid.
Marv Enterprises, Llc

Renal therapy system with cassette-based blood and dialysate pumping

A renal therapy system with cassette-based blood and dialysate pumping is disclosed. An example system includes a blood pump actuator, a dialysis fluid pump actuator, a dialysis fluid heater, a dialyzer, and a disposable unit.
Baxter Healthcare S.a.

Apparatus for extracorporeal blood treatment

An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. Spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood through the filtration unit (2), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant..
Gambro Lundia Ab

Blood pump

Apparatus and methods are described, including a catheter (20) configured to be placed inside a blood vessel of a subject. A first impeller (28) is disposed on the catheter, and a second impeller (28) is disposed on the catheter, proximally to the first impeller.
Magenta Medical Ltd.

Systems and methods for recovering white blood cells from a leukoreduction filter

A method of recovering white blood cells from a leukoreduction filter, the method comprising providing a solution comprising a sugar, flowing a volume of the solution through a leukoreduction filter containing captured white blood cells, and collecting elute from the leukoreduction filter, wherein the elute comprises the solution and recovered white blood cells.. .
Fenwal, Inc.

Immunoadsorption

Upon administration of raav vectors the humoral immune response (neutralizing antibodies) is the first barrier that needs to be overcome. Surprisingly it was found that by using immunoadsorption for depletion of immunoglobulins from the blood (plasma), subjects can be highly efficiently treated with raav vectors, i.e.
Uniqure Ip B.v.

Beta-casein a2 and antioxidant capacity

Improving the antioxidant capacity in an animal by increasing the level of glutathione in the blood or tissue of the animal comprising providing a composition containing beta-casein to the animal for consumption, where the beta-casein comprises at least 75% by weight of one or more beta-caseins not capable of producing beta-casomorphin-7 on enzymatic digestion. Uses include as an oxidant, for treating or preventing the symptoms of cancer, inflammation, kwashiorkor (protein deficiency), seizure, autism, down's syndrome, chronic fatigue syndrome, alzheimer's disease, parkinson's disease, sickle cell anaemia, liver disease, cystic fibrosis, hiv, aids, infection, heart attack, stroke, and diabetes, avoiding or reducing the effects of aging, promoting the recovery of tissue following physical exercise, and promoting fertility..
The A2 Milk Company Limited

Composition and methods for treatment of loss of fluids leading to hypotension and/or hypovolemia

The present invention is directed to a composition containing at least one salt, at least one natural or synthetic saccharide, and at least one natural or synthetic high molecular weight, non-ionic, hydrophilic polymer. When in a liquid form, the composition is ready for infusion or injection to patients that suffer from loss of fluids that causes reduced volume and/or pressure in the systemic circulation.
Cellphire, Inc.

Pet food compositions

Described herein are pet food compositions comprising a blood glucose management component comprising soy isoflavone and yeast beta-glucan (β-glucan); along with methods of making and using same.. .
Hill's Pet Nutrition, Inc.

Compositions and methods that modulate white blood cells or neutrophils in a companion animal

White blood cells and/or neutrophils in a companion animal can be improved by adjusting the diet of the animal to increase the amount of a compound which positively or negatively modulates the white blood cells and/or neutrophils or adjusting the diet of the animal to decrease the amount of a compound which positively or negatively modulates the white blood cells and/or neutrophils.. .
Nestec Sa

Treatment of restenosis using temsirolimus

Described herein are methods for distributing temsirolimus to a tissue surrounding a blood vessel for treating vascular diseases. Also disclosed are injectable compositions of temsirolimus for delivery into the tissue surrounding a blood vessel for treating vascular diseases..
Mercator Medsystems, Inc.

Chitosan nanofibres containing bioactive compounds

The invention relates to self-assembled nanofibers of chitosan and bioactive compounds for use as nutraceuticals or drugs. Suitable bioactive compounds include molecules of a low molecular size with acid or lactone groups, aromatic rings and hydroxyls.
Universidad De Valparaiso

Long acting liraglutide compositions

The present invention relates to a long acting composition comprising, therapeutically effective amount of liraglutide, a block or a graft copolymer comprising hydrophilic and hydrophobic moieties or mixtures thereof, at least one amphipath, and an aqueous vehicle, wherein the composition is in the form of a gel which is rendered injectable when forced through a needle by means of a plunger. The composition provides effective blood glucose control for about 6 days to about 14 days after single administration to a subject in need thereof, in particularly for about a week..
Sun Pharma Advanced Research Company Limited

Sublingual therapeutic solutions and methods

Supplement formulations of estrogen blocker, glycogen manager, and muscle recovery solutions and sublingual therapies for increasing absorption rates thereof. The sublingual delivery systems allow the body to absorb up to 94.9% of each dose directly into the bloodstream, completely bypassing the digestion process.

Methods for delivering entanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the gi tract. Many embodiments provide a swallowable device for delivering the agents.
Rani Therapeutics, Llc

Blood bag and blood bag label with such a label

The present invention relates to an adhesive label intended to be secured to a blood bag made of pvc, kraton, polypropylene or the like, wherein the adhesive label comprises a flexible support and a layer of pressure-sensitive adhesive deposited on one of the surfaces of the support; wherein the label is noteworthy in that the support has a mineral filler rate of silica and/or calcium carbonate (caco3) and/or the like, of less than 50%, and wherein at 115° c., the support has an elongation greater than or equal to 2% when a test piece 1.5 cm wide of the support is suspended under tension by a weight of 375 g for 75 minutes, and wherein the blood bag at 115° c. Has an elongation of at least 100% when a 1.5 cm wide test piece of a blood bag is suspended under tension by a weight of 375 g for 75 minutes..
Adhex Technologies

Method of air reduction in stent graft delivery device

Methods of reducing air within a stent graft delivery device are disclosed, utilizing various flushing techniques. A port in a manifold that includes a pusher catheter coaxially disposed about a guide wire catheter is flushed.
Cook Medical Technologies Llc

Stent apparatus and treatment methods

There is disclosed a method of treating hypoxia in tissue of a blood vessel, the method comprising placing a stent in the vessel, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall. There is disclosed a method of treating a subject with diabetic atherosclerosis, the method comprising placing a stent in a blood vessel of the subject, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall..
Veryan Medical Limited

Catheter-based apparatuses and methods

Blood flow into vascular tissue is filtered in a manner that can also be useful for trapping particulates while allowing the flow of blood. Consistent with one or more embodiments, a filter apparatus includes a filter, an outer delivery sheath such as a catheter, and one or more shafts that are operable to manipulate the shape of the filter for positioning within vascular tissue.
Transverse Medical, Inc.

Catheter-based apparatuses and methods

Blood flow into vascular tissue is filtered in a manner that can also be useful for trapping particulates while allowing the flow of blood. Consistent with one or more embodiments, a filter apparatus includes a filter, an outer delivery sheath such as a catheter, and one or more shafts that are operable to manipulate the shape of the filter for positioning within vascular tissue.
Transverse Medical, Inc.

Method for treatment of varicocele

A minimally invasive method for treating varices in especially sensitive areas, including pelvic varices in females, varicoceles, and also oesophageal varices is presented. The method comprises the steps of making a micro incision into the blood vessels of a patient, endoscopically inserting a catheter device into the blood vessel of a patient and advancing the distal end of the catheter to reach the varix or varices.
Biolitec Unternehmensbeteiligungs Ii Ag

Non-occlusive circumferential vascular ablation device

A device for internal circumferential ablation of a tubular vascular structure includes an expandable structure having a central opening extending therethrough to allow a relatively unobstructed flow of body fluid through the tubular vascular structure. The expandable structure is expandable from a collapsed configuration to an expanded configuration, with the expandable structure being configured to be secured in a desired location on the tubular vascular structure.
Persistent Afib Solutions, Inc.

Apparatus and method to stop bleeding

A hemostatic device is provided to stop bleeding at a puncture site on the wrist of a patient, the device comprising a transparent flexible band to be wrapped at the site where the bleeding is to be stopped, a curved frame having an inner peripheral side and possessing a first curved portion in its first half and a second curved portion in its second half, a first balloon provided on the inner peripheral side in the first half of the curved frame and a second balloon provided on the inner peripheral side in the second half of the curved frame. The bleeding from a first artery is stopped by compressing the first artery at the puncture site using inflation of the first balloon and the blood flow in the first artery is increased by compression of a second artery using inflation of the second balloon..
Vasoinnovations, Inc.

Photoplethysmography apparatus

The invention relates to a photoplethysmography apparatus (100), comprising a source of light (110) configured to provide source light (130) of at least a first and a second spectral position directed at a tissue (140); alight detector (120) configured to detect scattered source light, and to provide at least a first and a second sensor signal (127, 29) indicative of the scattered source light of the first and second spectral position; and a processing unit (150). The processing unit is configured to calculate a corrected sensor signal (160), indicative of a variation in blood absorbance within the tissue, by removing a tissue-path error signal component, indicative of a variation in optical path length through the tissue over time, and a light-coupling error signal component, indicative of a variation of source light intensity of the source light emitted at the tissue, from the at least first and second sensor signals..
Koninklijke Philips N.v.

Regional oximetry sensor

A regional oximetry sensor has a sensor head attachable to a patient skin surface so as to transmit optical radiation into the skin and receive that optical radiation after attenuation by blood flow within the skin. The sensor includes windows that press into the skin to maximize optical transmission.
Masimo Corporation

System and monitoring and determining patient parameters from sensed venous waveform

Devices, systems, and methods for monitoring patient hemodynamic status, systemic vascular resistance, reversal of cardiac and respiratory rates, and patient respiratory volume or effort are disclosed. A peripheral venous pressure is measured and used to detect levels, changes, or problems relating to patient blood volume.
Baxter Healthcare Sa

Brain activity estimation device

A brain activity estimation device includes a brain activity estimation portion. The brain activity estimation portion includes a blood-circulation-amount calculating unit and an estimation unit.
Tokyo Institute Of Technology

Gel based livestock feed, manufacture and use

The gel feed may then be fed to the livestock. In another aspect of the present invention, piglets are weaned by feeding the gel feed for at least seven days directly after weaning.

Methods and compositions for cryopreservation of endothelial cells

Brain microvascular endothelial cells (bmecs) can be generated from pluripotent stem cells, and possess membrane barrier functions along with capability for maturation into other developing tissues. This cell type has not been successfully frozen with loss of significant viability and/or bmec functional properties.
Cedars-sinai Medical Center

System for washing red blood cells to reduce hemolysis

A system for washing red blood cells, comprising a separator configured to separate a quantity of blood into concentrated red blood cells having a hematocrit of at least 60% and a volume of 150-250 ml, and a supernatant component. The system comprises a flow controller configured to remove the supernatant component to provide an initial red blood cell concentrate; combine 50-500 ml of an additive solution with the red blood cell concentrate to provide an intermediate red blood cell product intended for storage for 42 days or less, wherein the intermediate red blood cell product at the end of storage has an osmolarity value between 202-479 mosm/l; and wash the intermediate red blood cell product comprising the osmolarity value between 202-479 mosm/l with a washing solution having an osmolarity value higher than that of the intermediate red blood cell product comprising the osmolarity value between 202-479 mosm/l..
Fenwal, Inc.

Test panel to measure blood neurotoxin levels in prematernal women and for the general public in relation to mental disorders of the aging

A prescribed diagnostic blood test panel is directed to countering autistic and mentally affected births and assessing the continued healthy mental state of the elderly. Six neurotoxins in the blood are analyzed, five of which can produce damage to the brain, namely aluminum, arsenic, lead, mercury and manganese.

Methods of diagnosing clostridium difficile infection or recurrence in a subject

Methods are described for identifying cdi patients as well as cdi patients at risk for recurrence. Embodiments include: (1) flow cytometry of circulating peripheral blood mononuclear cells (pbmc) to phenotype for the less efficient immunoglobulin response to bacterial toxins and surface antigens that characterizes patients who will become recurrent; (2) stratification by means of complete blood count (cbc) using a coulter counter to detect the differences in lower angle light scatter (lal), which has a larger range in the recurrent population; and (3) stratification by means of complete blood count (cbc) using a coulter counter to detect the lower axial light loss (al2) exhibited in recurrent patients..
University Of Cincinnati

Method and determining a probability of colorectal cancer in a subject

A method of determining a probability that a human test subject has colorectal cancer as opposed to not having colorectal cancer is disclosed. The method comprises, for each gene of a set of one or more genes selected from the group consisting of anxa3, clec4d, il2rb, lmnb1, prrg4, tnfaip6 and vnn1: determining a level of rna encoded by the gene in blood of the test subject, thereby generating test data; providing positive control data representing levels of rna encoded by the gene in blood of human control subjects having colorectal cancer, and providing negative control data representing levels of rna encoded by the gene in blood of human control subjects not having colorectal cancer; and determining a probability that the test data corresponds to the positive control data and not to the negative control data, where the probability that the test data corresponds to the positive control data and not to the negative control data represents the probability that the test subject has colorectal cancer as opposed to not having colorectal cancer..
Genenews, Inc.

Methods for the detection of genomic copy changes in dna samples

The present invention includes compositions and methods useful for the detection of a mutational change, snp, translocation, inversion, deletion, change in copy number, or other genetic variation within a sample of cellular genomic dna or cell-free dna (cfdna). In some embodiments, the compositions and methods of the present invention provide an extremely high level of resolution that is particularly useful in detecting copy number variations in a small fraction of the total cfdna from a biological sample (e.g., blood)..
Resolution Bioscience, Inc.

Preservation of cell-free nucleic acids

A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids..
Streck, Inc.

Recombinant adeno-associated vectors for targeted treatment

Novel adeno-associated virus (aav) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues.
City Of Hope

Copolymer and medical device, separation membrane module for medical use, and blood purifier including the same

A copolymer has blood compatibility and antithrombotic properties of greatly suppressing protein adhesion to be usable even when in contact with a biological component such as blood for a long period of time, and a medical device uses the copolymer. The copolymer is characterized by including a hydrophilic unit and a hydrophobic unit, wherein the hydrophobic unit contains at least one type of a carboxylic acid vinyl unit, and the number of carbon atoms at the terminal of a side chain of the carboxylic acid vinyl unit is 2-7..
Toray Industries, Inc.

Substituted aromatic compounds and pharmaceutical uses thereof

The present invention relates to substituted aromatic compounds of formula i and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, a nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders..
Prometic Pharma Smt Limited

Integrated patient monitor system

A point-of-care medical testing system integrated with a patient monitor is disclosed. The system may include a microfluidic cartridge configured to receive a blood sample and generate a sensory signal dependent on a concentration of a biomarker in the blood sample.
Pooyandegan Rah Saadat Co.

Occluding catheter and dynamic prevention of stroke

A system for use in prevention of stroke is provided that has a shaft that carries an occluding balloon. The occluding balloon is inflated to occlude blood flow through at least one of a right carotid artery and a left carotid artery.

Intravenous catheter stopper

A stopper is provided for preventing blockage of a cannula of an intravenous catheter in-between uses including a hub having a connector for securing to the catheter, and a stylet having a length and a shape configured to fill a lumen of the cannula, where the hub is configured to place the stylet within the lumen of the cannula, and where the stylet is configured to prevent blood from clotting within the lumen of the cannula when inserted in a patient between uses. In some implementations, the stopper can have a movable stylet.
King Abdullah International Medical Research Center

Infusion pump system and methods

Some embodiments an infusion pump system can be configured to activate an alarm in response to a calculated prediction of the user's future blood glucose levels. Optionally, the predictive calculation of the user's future blood glucose levels can be based at least in part upon a recent blood glucose level, a trend of blood glucose levels over time, and an insulin load of the user..
Bigfoot Biomedical, Inc.

Dialysis bloodline set and use

A dialysis bloodline set includes an arterial chamber with upper, lower and central portions, in which the central portion forms a vertical riser tube having a maximum section area less than that of the lower portion. The lower portion has a shoulder which is positioned to deflect blood entering the lower portion to flow across the aperture at the lower end of the riser tube.
Oxyless Limited

Pump, system with a blood pump and producing a blood pump

The invention relates to a blood pump made of titanium with a measuring device for determining flow based on acoustic flow measurement methods, and a blood pump with a temperature sensor and/or a pressure sensor, and a system with a blood pump and an inlet cannula and/or an outlet connector and a method for producing a blood pump with a measuring device.. .
Heartware, Inc.

Device for controlling a blood flow produced in a hemorrhagic area

A device for controlling blood flow occurring in a haemorrhagic zone of a biological tissue, includes a flexible plate arranged to be placed opposite this zone, the flexible plate including: substantially leaktight peripheral supporting elements, for applying on the tissue so that the zone is surrounded; a back wall delimiting, with the supporting elements, opposite the zone, a hollow space; connecting elements connecting the hollow space, externally to the flexible plate, to an external aspiration source for creating a vacuum in the hollow space for aspirating and tightly applying the surface of the tissue against the peripheral supporting elements; and a hollow stud placed between the zone and the back wall and hollowed out in its centre on the side of the zone along an axis substantially perpendicular to the back wall, and arranged to be in contact with the zone when the vacuum is created in the space.. .
Centre Hospitalier Universitaire De Grenoble

Compositions and methods for transport across the blood brain barrier

Compositions and methods are provided including a transporter peptide derived from the loop2 domain of the neuronally-derived lynx protein which can be conjugated to an effector agent to form a transporter-effector complex for transport of the therapeutic effector agent to a target that is found across the blood brain barrier.. .
Ophidion Inc.

Truncated von willebrand factor polypeptides for treating hemophilia

The invention relates to a polypeptide comprising a truncated von willebrand factor (vwf) for use in the treatment of a blood coagulation disorder, wherein the polypeptide carries a half-life extending moiety and is administered in molar excess over factor viii and/or endogenous vwf.. .
Csl Behring Recombinant Facility Ag

Antidiabetic oral insulin biguanide combination

Pharmaceutical dosage forms, comprising insulin, a delivery agent that facilitates insulin transport in a therapeutically effective amount to the bloodstream and a biguanide, such as metformin, are disclosed for oral administration to a patient for the treatment of diabetes. Also disclosed are methods for achieving improved glucose tolerance and glycemic control in a diabetic mammal without any statistically significant increase in weight, risk of hypoglycemia or hyperinsulinemia, and the need for monitoring blood glucose concentrations or hba1c levels, and methods for reducing the incidence and/or severity of one or more disease states associated with chronic dosing of insulin; for prophylactically sparing (3-cell function or for preventing (3-cell death or dysfunction in a mammal with impaired glucose tolerance or early stage diabetes mellitus; and for long-term protection from developing (or delaying the onset of) overt or insulin dependent diabetes in a mammal with impaired glucose tolerance or early stage diabetes..
Emisphere Technologies, Inc.

Methods of obtaining mononuclear blood cells and uses thereof

Methods of obtaining mononuclear blood cells are provided. Also provided are methods of using the obtained cells for treating diseases such as cancer, infectious disease, autoimmune disease, allergy, and graft rejection..
Biolinerx Ltd.

Use of a block polymer comprising a block of poly(3-(methacryloylamino)propyltrimethylammonium chloride) (pmaptac) for the neutralization of heparin

The subject of the invention is use of block polymers with a block of poly(3-methacryloylpropyltrimethylammonium chloride) to direct neutralization of heparin, especially unfractionated heparin and low molecular weight heparins in the blood and other body fluids.. .
Uniwersytet Medyczny W Bialymstoku

Combination sis and vacuum bandage and method

A wound care bandage for treating a wound is provided. The bandage includes an sis layer to be placed on the wound surface and a cover to be placed over the wound.
Kci Medical Resources Unlimited Company

Concurrent treatment of oral and systemic maladies using direct current electricity

A method and apparatus for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing electricity are provided for non-human animals. Electrodes are used to deliver an electrical current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits.
Biolectrics Llc

Method and system for image processing to determine blood flow

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data.
Heartflow Inc.

Evaluating prosthetic heart valve placement

A method for evaluating the placement of a prosthetic heart valve in a structure of interest. The method comprises acquiring one or more depictions of an anatomical region of interest that includes the structure of interest, wherein each depiction shows the structure of interest and/or the blood pool volume of the left ventricular outflow tract (lvot) of the patient's heart.
Henry Ford Health System

Total laparoscopic two-stage surgical resection of side of liver of patient via liver-surrounding band method

The present invention discloses a completely laparoscopic staged hepatectomy using round-the-liver ligation, which is carried out as follows: (1) a complete laparoscopic operation is performed with general anesthesia using round-the-liver ligation, the branches of the portal vein of the hemiliver to be removed are ligated, meanwhile a tourniquet is used to tighten the connecting part between the right and the left hemilivers to block the communicating blood flow between the hemiliver to be removed and the hemiliver to be reserved, a drainage tube is put into the peritoneal cavity at the hepatic hilus, then close the peritoneal cavity, and the operation is completed; (2) the patient gradually resumes eating after the first operation, and recuperate for 6-15 days to make the volume of the hemiliver to be reserved increase to the expected volume of the future liver remnant, in which the expected volume of the future liver remnant should be at least 30-40% of the standard liver volume; (3) after the volume of the hemiliver to be reserved has increased to the expected volume of the future liver remnant, a complete laparoscopic liver resection is carried out with general anesthesia to remove the diseased hemiliver, and then the patient is nursed to be completely recovered.. .

Implantable medical device and system to heat tissue

A medical implant device (18) for atrial appendage (20) is presented, suitable to transmit energy to its surrounding. The medical implant device (18) comprising an expandable structure (31,34) and a cover (32) disposed on the expandable structure is adapted to extend across the ostium (21) of the atrial appendage (20) for restricting migration of thrombi from the appendage to the blood stream in the heart (13).
Koninklijke Philips N.v.

Cannula with proximally mounted camera

A cannula system and method for accessing a blood mass in the brain. The system comprises a cannula with a camera mounted on the proximal end of the cannula with a view into the cannula lumen and the surgical field below the lumen.
Rebound Therapeutics Corporation

Device for detecting blood flow disturbance

A blood flow disorder detection device includes: a sensor sheet including a flexible substrate and a plurality of sensors provided on the flexible substrate; and an analyzer that analyzes outputs of the plurality of sensors. The plurality of sensors measure different types of blood flow information of a living tissue, the blood flow information being obtained by attaching the sensor sheet to the living tissue.

Method and system for dealing with breathing anomalies

A system for dealing with breathing anomalies can monitor a subject for indications of breathing anomalies while the subject is sleeping. For example, the system can monitor blood oxygen saturation utilizing a pulse oximeter placed on a finger or toe, breathing rate utilizing a camera, or another appropriate physiological parameter.
Sensory Innovation Solutions, Inc.

Blood collection device

The application relates to a blood collection device comprising: a cannula hub defining a chamber; an in-let cannula defining an axis and having a distal end and a lumen extending therethrough, the inlet cannula being mounted to the cannula hub such that the distal end of the inlet cannula is external of the cannula hub and such that the lumen through the inlet cannula communicates with the chamber; an outlet cannula having a proximal end and a lumen extending therethrough, the outlet cannula being mounted to the cannula hub such that the proximal end of the outlet cannula is external of the cannula hub and such that the lumen of the outlet cannula communicates with the chamber; a closed sleeve mounted over a portion of the outlet cannula disposed externally of the cannula hub; and a venting mechanism providing communication between the chamber and ambient surroundings.. .
Poly Medicure Limited

Blood lancet with hygienic tip protection

The invention concerns lancets with a lancet needle, the tip of the lancet needle being embedded in an elastic material. Furthermore the invention concerns lancets where the tip of the lancet needle is surrounded by a hollow body which partially consists of an elastic material that can be pierced by the tip of the lancet needle during the lancing process and which reseals the tip of the lancet needle in the hollow body when it is retracted.
Roche Diabetes Care, Inc.

Biological information measurement system and biological information measurement method

A biological information measurement system includes a light emitting portion, a light receiving portion, a light detection portion, a wireless transmission portion, a reception portion that receives information to specify a change corresponding to an increase or a decrease in the concentration or the amount of hemoglobin, wirelessly transmitted from the wireless transmission portion, and a determination portion that monitors information regarding a change in a blood flow based on the information for specifying a change corresponding to an increase or a decrease in the concentration or the amount of hemoglobin, received by the reception portion, over time, and determines whether or not a rate of the change in a blood flow exceeds a predetermined reference value in a case where there is a change in the information regarding a change in a blood flow according to a timing of chest compressions of the subject.. .
Trilobite Co., Ltd.

System and tracking signal of wire

The system includes a stand surrounding a working area, a signal detector receiving a signal generated by the wire, and a positioning module disposed on the stand. The positioning module is configured to drive the signal detector moving forward and backward on a two-dimensional plane in the working area.
Metal Industries Research & Development Centre

Method and detecting atrial fibrillation

A method of detecting atrial fibrillation includes detecting a pulse signal to obtain a time pulse waveform and converting it to an energy spectrum waveform via fast fourier transform. The energy spectrum waveform includes a first frequency region, a second frequency region, and a third frequency region.

A device and non-invasive left ventricular end diastolic pressure (lvedp) measurement

The present application relates to systems and methods for non-invasively determining at least one of left ventricular end diastolic pressure (lvedp) or pulmonary capillary wedge pressure (pcwp) in a subject's heart, comprising: receiving, by a computer, a plurality of signals from a plurality of non-invasive sensors that measure a plurality of physiological effects that are correlated with functioning of said subject's heart, said plurality of physiological effects including at least one signal correlated with left ventricular blood pressure and at least one signal correlated with timing of heartbeat cycles of said subject's heart; training a machine learning model on said computer using said plurality of signals for periods of time in which said plurality of signals were being generated during a heart failure event of said subject's heart; determining said lvedp or pcwp using said machine learning model at a time subsequent to said training and subsequent to said heart failure event.. .
Boston Scientific Scimed Inc.

Combined physiological sensor systems and methods

A combined physiological sensor and methods for detecting one or more physiological characteristics of a subject are provided. The combined sensor (e.g., a forehead sensor) may be used to detect and/or calculate at least one of a pulse blood oxygen saturation level, a regional blood oxygen saturation level, a respiration rate, blood pressure, an electrical physiological signal (eps), a pulse transit time (ptt), body temperature associated with the subject, a depth of consciousness (doc) measurement, any other suitable physiological parameter, and any suitable combination thereof.
Covidien Lp

Photoacoustic, noninvasive, and continuous blood glucose measurement device

A photoacoustic, noninvasive, and continuous blood glucose measurement device includes: a diode laser for irradiating a living body with a pulsed laser signal having a specific wavelength; and an ultrasound transducer for measuring a photoacoustic signal in a form of ultrasonic waves generated by a reaction of the living body with the pulsed laser signal.. .
Postech Academy-industry Foundation

Apparatus and measuring blood flow of vessels

An apparatus and a method for measuring blood flow of vessels are provided. A light source, a light splitting module, a reference arm module, a sample arm module, a probing module, and a control system are arranged; the sample arm module includes a scanning unit and an optical-path shifting device; a probe light is obtained from the light splitting module, and a main light of the probe light is on a rotating shaft of the scanning unit; the probe light is reflected by the scanning unit to the optical-path shifting device, when the optical-path shifting device is in a first position and in a second position respectively, the probe light scans a vessel in fundus to obtain a first phase shift signal and a second phase shift signal blood flow rates and total blood flow of all the vessels near an optic disc are determined..
Shenzhen Certainn Technology Co., Ltd.

Blood tracking and delivery devices and methods

A blood tracking and delivery system server has processing circuitry configured to receive blood data at a blood database center, wherein a) the blood data is sorted and indexed into a plurality of database tables, b) each entry of a blood donor data table is cross-referenced to respective indexed entries of a blood classification data table, and c) each indexed entry of a blood recipient data table is cross-referenced to respective indexed entries the blood classification data table; receive a blood supply request; cross-match the blood criteria for the recipient with donor blood criteria from the blood donor data tables; and determine a delivery route for the blood supply cross-matched to the blood recipient destination, where an unmanned aerial vehicle uav is configured to deliver the blood supply to the blood recipient destination.. .

Self correction for spatial orientation and motion of portable clinical analyzers

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof..
Abbott Point Of Care Inc.

Apparatus for extracorporeal blood treatment comprising all-round display

An apparatus for extracorporeal blood treatment comprising a control unit and a display device, wherein the apparatus for extracorporeal blood treatment is equipped with a person locating and identifying device and the person locating and identifying device and the display device are in contact of information exchange with each other via the control unit and the person locating and identifying device is adapted to obtain and to process information about the position of a person being located in the environment of the apparatus for extracorporeal blood treatment, and the display device is adapted to display on a display information in response to the position of the person so that it is visible from the position of the person.. .
B. Braun Avitum Ag

System and determining risk of diabetes based on biochemical marker analysis

A method for predicting risk of gestational diabetes mellitus (gdm) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of pai-2 and stnfr1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing gdm.. .
Wallac Oy

Methods for diagnosis and prognosis of cancers of epithelial origin

Adam 12 expression and activity are up regulated in patients that have cancers of epithelial origin, such as breast cancer, colon cancer, prostate cancer, liver cancer, bladder cancer, pancreatic cancer, ovarian cancer, cervical cancer, lung cancer, and skin cancer, as well as others: accordingly, the present invention is directed to methods for prognostic evaluation, and diagnosis of cancers of epithelial origin. In particular, the presence of adam 12 in a biological sample is indicative of cancer of epithelial origin.
Children's Medical Center Corporation

Blood test method

A blood test method includes providing a blood sample containing an anticoagulant containing an ethylenediaminetetraacetic acid (edta) salt other than a sodium, potassium, or calcium salt of edta, and then measuring a blood count and an electrolyte in the provided blood sample.. .
Arkray, Inc.

Kit for diagnosis of coronary heart disease using multi-metabolites and clinical parameters, and diagnosis of coronary heart disease using the same

The present disclosure relates to a method and a diagnostic kit for diagnosing stable angina and acute myocardial infarction early through simple blood testing and checking of clinical parameters. Unlike conventional diagnostic methods, stable angina can be diagnosed as distinguished from acute myocardial infarction according to the present disclosure by using one diagnostic platform based on the change in the in-vivo levels of biological metabolites having different metabolic pathways and clinical parameters as well as medications affecting the onset and progress of the disease through multivariable analysis..
Korea Institute Of Science And Technology

Automated slide assessments and tracking in digital microscopy

The present disclosure provides methods for automated slide assessments made in conjunction with digital image-based microscopy. Automated methods of acquiring patient information and specimen information from prepared slides, and digitally linking such information into patient-tagged specimen data, are provided.
Abbott Laboratories

Marker for prenatal diagnosis and monitoring

The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal dna present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal dna and in maternal dna and provides these new diagnostic methods, which distinguish fetal dna from maternal dna and detect prenatal disorders based on abnormalities in fetal dna level and methylation status..
The Chinese University Of Hong Kong

Genomic alterations in the tumor and circulation of pancreatic cancer patients

Pancreatic adenocarcinoma has the worst overall mortality of any solid tumor, with only 7% of patients surviving after 5 years. To evaluate the clinical implications of genomic alterations in this low cellularity tumor type, we deeply sequenced the genomes of 101 enriched pancreatic adenocarcinomas from patients who underwent potentially curative resections and used non-invasive approaches to examine tumor specific mutations in the circulation of these patients.
The Johns Hopkins University

Method for preparing natural killer cells using irradiated pbmcs, and anti-cancer cell therapeutic agent comprising the nk cells

Provided is a method for preparing natural killer cell with high efficiency using irradiated peripheral blood mononuclear cells, more particularly to a method for proliferating highly activated nk cells using a combination of irradiated peripheral blood mononuclear cells (pbmcs) and a cd16 antibody and an anti-cancer cell therapeutic composition containing the natural killer cells (nk cells) prepared thereby. Further provided is a method for large-scale proliferation of activated nk cells with high efficiency using a combination of irradiated peripheral blood mononuclear cells (pbmcs) and a cd16 antibody without the use of cancer cells or genetically modified feeder cells having safety issues as feeder cells.
Korea Institute Of Radiological & Medical Sciences

Tfpi inhibitors and methods of use

The invention provides peptides that bind tissue factor pathway inhibitor (tfpi), including tfpi-inhibitory peptides, and compositions thereof. Peptide complexes also are provided.
Baxalta Incorporated

Diaryl isoxazoline compound

The present invention concerns compounds of formula (i) or an n-oxide or salt thereof and their use for controlling parasites in and on warm-blooded animals or fish.. .
Elanco Tiergesundheit Ag

Cationic lipid

Wherein each symbol is as defined in the description, is superior in the stability in blood and tumor accumulation property. A nucleic acid-introducing agent using the cationic lipid can achieve high nucleic acid delivery efficiency of nucleic acid to be delivered into the cytoplasm..

Red blood cell washing system

A blood washing system including a rotor defining an internal chamber and a skimmer assembly configured to move a withdrawal needle within the internal chamber. A multi-component fluid, such as a whole blood sample, can be fed into the internal chamber via a feed tube, where the rotor can be rotated to fractionate the multi-component fluid.

Blood washing and separation system

A separation rotor having an outer wall defining a separation chamber and an inner annular wall dividing the separation chamber into an inner annular space and an outer annular space. The separation rotor can be rotated to move heavier and/or denser components of the multi-component fluid into the outer annular space.

Separators for blood collection tubes

Sample collection tubes and methods of producing the same are provided. Contemplated collection tubes comprise a tube having a separator substance disposed therein.
University Of Maryland

Red blood cell elutriation wash system

A funnel element having an open end and a closed pointed end configured to receive a multi-component fluid containing a solid fraction. The solid fraction can comprise cellular material that sediments toward the closed pointed end to form a cell pack.

Application of high-intensity focused ultrasound system to treatment of essential hypertension

An application of a high-intensity focused ultrasound system to treatment of essential hypertension. A treatment process includes: conducting ultrasonic positioning measurement on both sides of perirenal fat tissue of a patient, setting a therapeutic window and parameters of the system, and setting corresponding power parameter of the system, so as to make local temperature of the tissue during treatment reach 40-70° c., wherein treatment portions are both sides, and treatment scope is one third to all of the whole tissue; starting the system to treat one side of the tissue according to the set parameters and then the other.
Nanjing Khons Medtech Co., Ltd.

Systems and methods for reducing or altering oral bacteria and methods for manufacturing the same

A method and apparatus for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing direct current electricity and methods for manufacturing the same. Electrodes are used to deliver a direct current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits.
Biolectrics Llc

Conductive pad for pain relieving and muscle training

A conductive pad for pain relieving and muscle training, comprises an electrode sheet electrically connected to a control unit and a conductive gel for attaching onto the human body. The conductive gel is added with a substance for pain relieving and muscle training, which is capsaicin, menthol, lidocaine, or other substitutes in an amount of 0.001% to 30% by mass.
Jkh Health Co., Ltd.

Length-adjustable catheter and method that employs a length-adjustable catheter to treat vascular pathologies

The current document is directed to length-adjustable catheters and methods that employ length-adjustable catheters to treat malformations, constrictions, obstructions, lesions, and blockages within patients' blood vessels. The length of the shaft of a length-adjustable catheter, to which the current application is directed, can be adjusted over a range of lengths prior to and during medical procedures.
Cti Vascular Ag

Congestive heart failure therapy device

Provided is a congestive heart failure therapy device that applies a positive pressure within an optimal range depending on the condition of a congestive heart failure (chf) patient. Provided is a positive pressure therapy device for congestive heart failure patients, comprising: a pressure raising unit configured to raise the pressure of air, or a gas mixture of air and other gases, to a positive pressure; an introducing unit configured to introduce the air or the gas mixture set to a positive pressure into the airways of the patient; and a blood oxygen level measurement unit configured to measure the blood oxygen level of the patient, a blood flow rate measuring unit configured to measure a blood flow rate of the patient, or a cardiac output measuring unit configured to measure a cardiac output of the patient.
Teijin Pharma Limited

Composite fluid separation

Embodiments are described that include systems and methods for separating components of a composite fluid, e.g., whole blood. Some embodiments provide for processing a composite fluid by subjecting a volume of the fluid to a first centripetal acceleration for an initial separation, followed by a second centripetal acceleration for a second separation..
Terumo Bct, Inc.

Devices, methods, and systems for priming, separating, and collecting blood components

A photopheresis system (200) is disclosed, and that may be configured to execute one or more protocols. These protocols include: 1) protocols (400; 430; 460) for purging air out of a centrifuge bowl (210) used by the photopheresis system (200); 2) protocols (500; 510 550) for assessing the installation/operation of one or more pressure domes (330) used by the photopheresis system (200); and 3) protocols (580; 600; 660; 700; 740) for collecting buffy coat from blood processed by the photopheresis system (200)..
Mallinckrodt Hospital Products Ip Limited

System and removing fat from salvaged blood

A method for removing fat from salvaged blood includes transferring salvaged blood from a reservoir to a blood component separation device, and separating the blood into a plurality of blood components. The method may then transfer a volume of unwashed blood components from the blood component separation device back toward the reservoir, and recentrifuge the blood components remaining within the blood component separation device.
Haemonetics Corporation

Methods and devices for removal of immunosuppressive ligands

The present disclosure relates to methods of removing soluble nkg2d ligands, including soluble mica, soluble micb and soluble ulbp proteins, from blood to treat diseases characterized by abnormal levels of soluble nkg2d ligands. Further provided are systems and devices for carrying out the therapeutic methods..
Novelogics Biotechnology, Inc.

Methods and systems for establishing retrograde carotid arterial blood flow

Interventional procedures on the carotid arteries are performed through a transcervical access while retrograde blood flow is established from the internal carotid artery to a venous or external location. A system for use in accessing and treating a carotid artery includes an arterial access device, a shunt fluidly connected to the arterial access device, and a flow control assembly coupled to the shunt and adapted to regulate blood flow through the shunt between at least a first blood flow state and at least a second blood flow state.
Silk Road Medical, Inc.

Dialysis catheter

A dialysis catheter including a first portion having a first diameter, an elongated distal portion having a second smaller diameter, and a transition portion the first portion includes first and second independent blood withdrawal lumens extending in the first portion, the first withdrawal lumen terminating in the transition portion in a first terminal opening and the second withdrawal lumen terminating in a second terminal opening, the first and second terminal openings being radially spaced and axially adjacent. A longitudinally extending blood delivery lumen extends in the first portion and terminates in a delivery opening in the distal portion of the catheter, the first and second terminal openings positioned proximally of the delivery opening and each of the first and second terminal openings having a curved wall surrounding a portion of the terminal opening..
Argon Medical Devices, Inc.

Control system

A control system for controlling a quantity of blood in a blood reservoir (10) of a perfusion system supplied by a venous line (v), wherein a pump (20) circulates blood from the blood reservoir (10) through an outgoing line(a), comprises a venous flow sensor (22) to measure a venous blood flow rate,an outlet flow sensor (24) to measure an outgoing blood flow rate, and a controller to control the pump (20) to prevent the outgoing blood flow rate from exceeding the venous blood flow rate. Thereby,a decrease of blood in the blood reservoir(10) can be arrested..
Spectrum Medical Ltd.

Dialysis machine

A disposable cartridge for use in a hemodialysis machine has a blood flow path for carrying a volume of blood to be treated in a dialyser and a dialysate flow path, isolated from the blood flow path, for delivering a flow of dialysate solution through the dialyser. The cartridge is received in an engine section of the machine.
Quanta Dialysis Technologies Limited

Aortic pump devices and methods

A disclosed apparatus or method can include or use a non-transluminally implantantable blood pump housing, which can be sized and shaped to be implanted at an aortic valve of a human subject, the pump housing can include: a pump housing cross-sectional profile size that is larger than is passable via a blood vessel of the human subject; and a power connection, configured for being electrically connected to an intravascular lead that is sized and shaped to extend from the pump housing through a subclavian artery of the human subject.. .
Berlin Heart Gmbh

Self-contained heart pump

A heart pump includes a rotative impeller partly inserted into the systemic ventricle, this rotative impeller being equipped with a membrane sutured to the outer wall of the heart in such a way as to secure the rotative impeller to the wall of the heart, a housing arranged inside the systemic ventricle in such a way as to draw up then discharge blood, a motor connected to the housing and arranged partly outside the systemic ventricle in such a way as to facilitate maintenance; an integrated management unit in the epigastric region including a power supply and a rotative impeller control unit; and a wired link between the management unit and the rotative impeller.. .
Fineheart

Blood component pooling device, system and method

A device for pooling a blood component stored in source containers includes a pump or pumps configured to pump a fluid in a first direction and a second direction and receive a pump line having a first end connected to the source containers. A pool clamp is configured to receive a pool line having a first end connected to a second end of the pump line and a second end connected to a pool container.
Fenwal, Inc.

Filter element for blood processing filter and blood processing filter

The present invention provides a filter element for a blood processing filter, comprising a nonwoven fabric, wherein the quantity of crystallization heat of the uncrystallized portion of the nonwoven fabric is 5 j/g or smaller before steam heat treatment.. .
Asahi Kasei Medical Co., Ltd.

Glycemic control using intrinsic factor bound to a vitamin b12 conjugate of a glucagon-like peptide-1 receptor agonist

The present invention provides compositions and methods for lowering blood glucose. More specifically, the present invention provides compositions comprising a complex comprising if and b12 conjugated to a peptide comprising a glp-1 agonist.
Syracuse University

Methods of reducing extravasation of inflammatory cells

A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue.
Acorda Therapeutics, Inc.

Composition and uses thereof

The invention relates to compositions comprising pinus pinaster stem bark extract, papain, and aloe vera extract, and methods of manufacturing same. There are also described methods of treating or preventing a variety of conditions, including treating or preventing elevated blood glucose, pre-diabetes, type 2 diabetes, autoimmune diseases, reducing or decreasing inflammation, treating or preventing diseases characterised by elevated levels of inflammation, and lowering blood cholesterol, said methods comprising administering an effective amount of a composition according to the invention to a subject in need thereof.
Arborvitae Health And Wellbeing Pty. Ltd.

Methods for detecting risk of having a bloodstream infection and compositions for reducing the risk

Provided herein is a method for determining the relative abundance of total bacterial in a sample. Optionally, the method also includes determining whether the subject has a risk of bloodstream infection after chemotherapy, such as a chemotherapy used to prepare a subject for a hematopoietic stem cell transplantation procedure.
Centre Hospitalier Universitaire De Nantes

Treatment of graft versus host disease in transplant patients

The present invention relates to a method of treating patients who undergo hematopoietic stem cell transplantation (hsct) with peripheral blood mobilized stem cells for hematological malignancies and for whom the risk for severe acute graft versus host disease (gvhd) is considerable.. .
Kyorin Pharmaceutical Co., Ltd.

Treating vasculature related diseases or disorders using nanoparticles

The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder.
The Regents Of The University Of California

Spray-dried blood products and methods of making same

The present invention is directed to a method of preparing dehydrated blood products, comprising the steps of: (a) providing a hydrated blood product; (b) spray-drying the hydrated blood product to produce a dehydrated blood product, as well as dehydrated blood products made by the method. The present invention is directed to a method of treating a patient suffering from a blood-related disorder, comprising the steps of: (a) rehydrating a therapeutic amount of the dehydrated blood products to produce a rehydrated therapeutic composition; and (b) administering the rehydrated therapeutic composition to the patient.
Entegrion, Inc.

Stable glucagon peptide formulations

There is provided glucagon formulations suitable for preparing coatings on microneedle patches for the transdermal delivery of glucagon. The coated patches may be used for the treatment of low blood sugar in diabetic patients.
Zp Opco, Inc.

Vascular implant

A vascular graft configured for occluding a vasculature of a patient including a biocompatible polymeric textile structure formed of a plurality of filaments spaced to enable blood flow through spaces between the filaments. The textile structure forms a tubular body having a first longitudinally extending opening.
Naurogami Medical, Inc.

Intravascular stent and manufacturing method thereof

Disclosed herein is an intravascular stent for being implanted into blood vessels and a method for manufacturing the same. The intravascular stent is woven by at least one weaving wire, and the stent is in a tubular structure.
Suzhou Innomed Medical Device Co., Ltd.

Ivc filter with translating hooks

A filter with translating hooks is described. The filter can include strut members having first and second struts connected by a connecting portion.
C.r. Bard, Inc.

Method and invasive device tracking using organ timing signal generated from mps sensors

Apparatus for generating an organ timing signal relating to an inspected organ within the body of a patient, including a medical positioning system, and a processor coupled with the medical positioning system, the medical positioning system including at least one reference electromagnetic transducer placed at a reference location, at least one inner electromagnetic transducer attached to a surgical tool inserted in a blood vessel in the vicinity of the inspected organ, and a medical positioning system processor coupled with the reference electromagnetic transducer and the inner electromagnetic transducer, the medical positioning system processor determining the three-dimensional position of the inner electromagnetic transducer, by processing transmitted electromagnetic signals transmitted from one of the reference electromagnetic transducer and the inner electromagnetic transducer with detected electromagnetic signals detected by the other of the reference electromagnetic transducer and the inner electromagnetic transducer, the medical positioning system processor further generating medical positioning system data sets, each of the medical positioning system data sets including a collection of three-dimensional position coordinate readings demonstrating the motion trajectory of the surgical tool over time, the processor generating the organ timing signal from the medical positioning system data sets by detecting and identifying periodic motion frequencies in the medical positioning system data sets, and filtering the periodic motion frequencies from the medical positioning system data sets.. .
Mediguide Ltd.

Shock wave balloon catheter with insertable electrodes

A translatable shock wave treatment apparatus is suitable for use in treating calcified lesions in vascular structures having small diameters. An elongate member carrying a collapsed angioplasty balloon is first inserted into the occluded blood vessel.
Shockwave Medical, Inc.

Tissue sampling devices, systems and methods

Methods, devices, and systems are described herein that allow for improved sampling of tissue from remote sites in the body. A tissue sampling device comprises a handle allowing single hand operation.

Devices and methods for collecting and stabilizing biological samples

The present invention generally relates to devices and methods for collecting and stabilizing biological samples, and more particularly, for collecting and stabilizing blood or other bodily fluids from a user's fingertip, earlobe, heel or other locations. The present invention also relates to sample collection devices that simplify the process for mixing the biological samples with an additive or additives, provide for efficient storage and safe transport of the samples, and provide for easy access to the samples for subsequent processing..
Dxterity Diagnostics Incorporation

Stand-alone continuous cardiac doppler pulse monitoring patch with integral visual and auditory alerts, and patch-display system and method

A stand-alone continuous cardiac doppler pulse monitoring patch provides visual and auditory signals that a pulse is detected or not detected in a human subject. The invention is a small patch with a peel-away adhesive surface that is applied to the skin of the subject, preferably near a large artery.

Synthetic data-driven hemodynamic determination in medical imaging

In hemodynamic determination in medical imaging, the classifier is trained from synthetic data rather than relying on training data from other patients. A computer model (in silico) may be perturbed in many different ways to generate many different examples.
Siemens Healthcare Gmbh

Stroke detection using blood pressure surge

This document discusses, among other things, systems and methods for detecting stroke. A system may comprise a sensor circuit for sensing a physiological signal, and a second sensor to detect a physical state change.
Cardiac Pacemakers, Inc.

Arterial and venous blood metrics

A medical device including a probe configured to be orally inserted into a lumen extending into the thorax of the subject, a plurality of electrodes, and a control circuit. The probe includes a first electrode.
Zoll Medical Corporation

Apparatus and measuring biologic parameters

Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body.
Geelux Holdings, Ltd.

Method and vital signs measurement

A method of monitoring changes in oxygen saturation of a subject by analysing a three colour channel video image of the exposed skin of the subject. Within each colour channel a normalised signal obtained by dividing the intensity signal by its mean value, and the normalised signals are averaged across plural regions of interest within the exposed skin area image of the subject.
Oxford University Innovation Limited

Analyte sensor receiver apparatus and methods

Receiver apparatus for use with an analyte sensor, and methods of operation and manufacturing. In one embodiment, the analyte sensor is an implanted/implantable blood glucose sensor, including oxygen-based detector elements.
Glysens Incorporated

Opticoustic sensor

A physiological sensor has an optic assembly, an acoustic assembly and an attachment assembly. The optic assembly has an optic transducer that is activated so as to transmit a plurality of wavelengths of light into a tissue site and to detect the light after attenuation by pulsatile blood flow within the tissue site.
Masimo Corporation

Syst