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This page is updated frequently with new Wound Healing-related patent applications. Subscribe to the Wound Healing RSS feed to automatically get the update: related Wound RSS feeds. RSS updates for this page: Wound Healing RSS RSS



Date/App# patent app List of recent Wound Healing-related patents
08/27/15
20150238666 
 System for tissue dissection and aspiration patent thumbnailSystem for tissue dissection and aspiration
A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece.
Ulthera, Inc.


08/27/15
20150238648 
 Silver-copper-zinc oxide wound care system patent thumbnailSilver-copper-zinc oxide wound care system
A wound care system for promoting wound healing and for preventing infections thereof and a method for producing the same includes an anti-microbial solution and a multi-layer wound dressing. The anti-microbial solution contains a mixture of colloidal silver, colloidal copper and colloidal zinc mixed in sterile purified water.

08/27/15
20150238527 
 Vitamin supplement compositions for injection patent thumbnailVitamin supplement compositions for injection
The embodiments relate to improved vitamin supplement compositions formulated for administration to patients, particularly improved vitamin compositions formulated for use in cosmetic or therapeutic applications. The compositions may be used to slow aging process and promote wellness including treating a vitamin deficiency, skin conditions, improving skin appearance, wound healing and scar prevention and hair loss..
Aquavit Pharmaceuticals, Inc.


08/27/15
20150238465 
 Novel, protective, anti-inflammatory receptor and its use in preservation of mitochondrial function, wound healing and repair patent thumbnailNovel, protective, anti-inflammatory receptor and its use in preservation of mitochondrial function, wound healing and repair
Provided herein is a novel mitochondrial angiotensin ii type 1 and type 2 at1r and at2r receptor which plays a role in protection of mitochondria against oxidative damage. Evidence from animal studies indicates a role for this receptor in preservation of mitochondria and up-regulation of survival genes, anti-inflammatory action, and improvement of wound healing in the skin and soft tissues.
The Johns Hopkins University


08/27/15
20150237837 
 Non-human model for wound healing patent thumbnailNon-human model for wound healing
The present disclosure provides a rodent scar contracture model to study scar contractures and methods of using such a model. Such uses may include, but are not limited to, testing mechanisms or action or developing new anti-scar contracture compounds..
Duke University


08/20/15
20150231170 
 Wound healing compositions comprising microspheres patent thumbnailWound healing compositions comprising microspheres
Pharmaceutical or medical compositions for treating a wound are provided, the composition comprise microspheres as an active ingredient and water as a carrier for said microspheres. In some embodiments, compositions comprising a thickening agent dissolved within the water to form a solution having a specific gravity similar to that of the microspheres are provided..
Polyheal Ltd.


08/13/15
20150224167 
 Composition for promoting wound healing patent thumbnailComposition for promoting wound healing
The present disclosure relates to a composition for promoting wound healing that may be used as a pharmaceutical composition, or a cosmetic composition for promoting wound healing, which contains a polypeptide including an amino acid sequence of seq id no 1. The composition may be usefully used for a wound care drug or a functional cosmetic product for wound care..
Industry-academic Cooperation Foundation, Yonsei University


08/06/15
20150218222 
 Medicaments patent thumbnailMedicaments
The present invention relates to the use of a peptide, or derivative thereof of general formula x1—x2—x3-thr-x4-lys-x5-arg-x6 for promoting accelerated wound healing with reduced scarring. X1 is ala or gly; x2 is tyr or phe; x3, x4 and x5 are independently selected from the group comprising met, ile, leu and val; and x6 is selected from the group comprising asp, gln and glu..
Armo Biosciences, Inc.


08/06/15
20150217134 
 Skin wound healing and hair growth patent thumbnailSkin wound healing and hair growth
Disclosed are devices and methods that can help heal skin wounds and grow hair by irradiating light from light emitting diodes (led). One device is provided with: an ultra-narrowband light irradiation means which generates ultra-narrowband red light with peak wavelength range 620-660 nm and fwhm 10 nm or less; an ultra-narrowband light irradiation means which generates ultra-narrowband green light with peak wavelength range 500-540 nm and fwhm 10 nm or less; an ultra-narrowband light irradiation means which generates ultra-narrowband blue light with peak wavelength range 440-480 nm and fwhm 10 nm or less; and an ultra-narrowband light irradiation means which generates ultra-narrowband red to near infrared light with peak wavelength range 700-2500 nm and fwhm 10 nm or less.
Mignon Belle Co., Ltd.


08/06/15
20150216946 
 Composition for reduced scar formation of wounds patent thumbnailComposition for reduced scar formation of wounds
A composition for reduced scar formation of wounds includes hydrolyzed collagen and one or more supplemental ingredients, including, lipoic acid, a zinc component, and a glucosamine component. The composition may facilitate inhibition of scar formation during wound healing.

08/06/15
20150216597 

Multiple beam laser treatment device


Embodiments of the invention include a treatment device and corresponding treatment method for laser wound healing, the device and method making use of the simultaneous action of multiple laser types and laser wavelengths which are applied at human tissue. The treatment device generally includes a laser system and a hand-piece which is coupled to the laser system.
Biolase, Inc.


08/06/15
20150216545 

Method and tissue harvesting


Exemplary methods and devices can be provided for harvesting a plurality of small tissue pieces, e.g., having widths less than about 1 mm or 0.5 mm, using one or more hollow needles. A fluid can be flowed through a conduit past the proximal ends of the needles to facilitate removal of the tissue pieces from the needle lumens, and can maintain the tissue pieces in a controlled and protective liquid environment.
The General Hospital Corporation


07/30/15
20150209564 

Ultrasound device and therapeutic methods


The present invention is directed to an ultrasound device for use in implementing therapeutic treatments and transdermal analyte delivery. The device includes a piezoelectric transducer that efficiently and safely converts electrical energy to ultrasonic waves, and has a unique structure including a piezoelectric element positioned between two opposing, flexible concave covers.
Drexel University


07/30/15
20150209492 

Apparatus for aspirating, irrigating and cleansing wounds


An apparatus for cleansing wounds in which irrigant fluid from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing. The cleansing means (which may be a single-phase, e.g.
Smith & Nephew Plc


07/30/15
20150209478 

Articles for tissue regeneration with biodegradable polymer


The invention is to articles made from extracellular matrix sheets that encase biodegradable polymeric material. Methods of healing wounds or regenerating tissue at sites of defect by placing said articles in mammals are claimed.
Cormatrix Cardiovascular, Inc.


07/30/15
20150209069 

Scalpel


A scalpel for cutting soft tissues of the body with an abrasive trailing surface. The abrasive trailing surface reduces distinct scar formation by supporting wound healing.

07/23/15
20150202258 

Medicament for wound treatment


The invention relates to stathmin, stathmin, a nucleic acid encoding said stathmin or a cell expressing stathmin for use in the treatment of chronic wounds or disease- or medication-dependent impaired wound healing in a patient or for increasing or inducing the proliferation and/or migration of mesenchymal cells, of stem cells, for stimulating immune cells, preferably natural killer cells, for stimulating fibroblasts, for stimulating epithelial cells, preferably epithelial cells of the epidermis, or for stimulating angiogenesis.. .
Simu Trade Consulting Gmbh & Co. Leasing Kg


07/23/15
20150202251 

Multimeric tie 2 agonists and uses thereof in stimulating angiogenesis


The present invention provides a multimeric form of a tie 2 binding peptide monomer, wherein the multimeric form has tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates angiogenesis and promotes wound healing.
Sunnybrook Health Sciences Centre


07/16/15
20150197507 

4-aminoquinazolinyl compounds as prolyl hydroxylase inhibitors


Which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by prolyl hydroxylase activity.

07/16/15
20150196616 

Angiopoietin-like 4 and a its use in wound healing


A method and a pharmaceutical composition for increasing wound healing in an individual in need thereof, the method comprising administering an angiopoietin like 4 (angptl4) polypeptide or a therapeutically active fragment thereof.. .
Nanyang Technological University


07/09/15
20150190559 

Wound healing system using positive pressure to promote granulation at a tissue site


A wound healing system for promoting healing of a wound of a patient includes a positive pressure source, a reduced pressure source, and a porous foam positioned in contact with the wound. The porous foam includes a plurality of flow channels in fluid communication with the reduced pressure source.
Kci Licensing, Inc.


07/09/15
20150190504 

Wound healing


The present invention relates to the use of p38 map kinase inhibitors and p38 map kinase inhibition to promote wound healing.. .
Systagenix Wound Management (us), Inc.


07/09/15
20150190351 

Compounds with (1e, 6e)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof


The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, a wound (the compounds assist with wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and alopecia; kennedy's disease (spinal and bulbar muscular atrophy, or sbma), polyglutamine-mediated motor neuron degeneration; cancers such as prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (liver) cancer, and pancreatic cancer; and other medical conditions described herein.

07/02/15
20150183832 

Use of pedf-derived polypeptides for promoting stem cells proliferation and wound healing


Disclosed herein is a synthetic peptide, which has an amino acid sequence that has 20-39 amino acid residues. The synthetic peptide has at least 80% amino acid sequence identity to seq id no: 1, and includes at least 20 consecutive residues that has at least 90% amino acid sequence identity to residues 11-30 of seq id no: 1.
Mackay Memorial Hospital


07/02/15
20150182570 

Composition having a. paniculata for wound healing and skin whitening, and method by using the same


The present invention provides a pharmaceutical composition for wound healing and/or skin whitening. The pharmaceutical composition comprises active ingredient of andrographis paniculata extract and/or andrographolide and a pharmaceutical acceptable carrier.
National Dong Hua University


07/02/15
20150182554 

Surface active agent compositions and methods for enhancing oxygenation, reducing bacteria and improving wound healing at a site of treatment


This present invention relates generally to the use of novel formulations comprising a surface active polymer to enhance oxygenation in skin and other soft tissue. The present invention also discloses formulations that can be used to improve clinical outlook and reducing bacteria.
Plurogen Therapeutics, Inc.


06/25/15
20150174306 

Wound cleansing apparatus


An apparatus for cleansing and promoting tissue growth in wounds, in which irrigant fluid optionally containing cell nutrients and/or other physiologically active material from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing, a biodegradable scaffold in contact with the wound bed and a means for fluid cleansing and back to the dressing. The apparatus has means for supplying thermal energy to the fluid in the wound.
Smith & Nephew Plc


06/25/15
20150174208 

Cosmetic and pharmaceutical composition with modified olygopeptides in form of supramolecular assembly


The invention is a cosmetic and pharmaceutical liposomal composition which comprises a mixture of carboxylated oligopeptides derived from natural polypeptides; insulin; hyaluronidase and collagenase by their enzymatic hydrolysis; followed by a carboxylation of the free amino groups of lysine, histidine, and additional hydrolysis of terminal amino groups in the oligopeptides. Natural polypeptides may be hydrolyzed with a proteolytic enzyme to form a mixture of oligopeptides and succinylated them.

06/25/15
20150174196 

Compositions and methods for wound healing and tissue repair


Provided are peptides that can inhibit collagen synthesis, processing and/or secretion from scar forming cells or fibroblasts. Also provided are methods for using the peptides to produce an anti-fibrotic, anti-scarring, anti-inflammatory, and/or pro-regenerative effect, e.g., on an injured or diseased tissue..
Musc Foundation For Research Development


06/25/15
20150173954 

Apparatus for aspirating, irrigating and cleansing wounds


An apparatus for cleansing wounds in which irrigant fluid from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing. The cleansing means (which may be a single-phase, e.g.
Smith & Nephew Plc


06/18/15
20150165462 

Systems and methods for fabricating spiral coils with atomized bioactive coatings


Systems and methods for coating of spiral intracranial aneurysm coils, e.g., a guglielmi detachable coil (gdc), such that only selected surfaces along the spiral coil are coated with a polymer via an atomized polymer deposition process. The resulting device is a detachable aneurysm coil system which preserves the mechanical geometry and flexibility of the coil, and delivers specific agents to promote wound healing..
The Regents Of The University Of California


06/18/15
20150165101 

Wound cleansing apparatus in-situ


An apparatus for cleansing wounds, in which wound exudate is removed from a wound bed and selectively cleansed and returned to the wound. The cleansing means removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed.
Smith & Nephew Plc


06/18/15
20150164994 

Systems and methods for angiogenic treatment in wound healing


The invention relates to systems and methods for the diagnosis, amelioration, and treatment of ischemic tissues in patients caused by and/or resulting from diminished microvascular blood flow. Patients suffering from ischemic tissue conditions can be categorized into specific subsets that are deemed to have a potential to respond to therapy.
Cardiovascular Biotherapeutics, Inc.


06/18/15
20150164961 

Methods and compositions for treatment of penile defects


A composition for use in treating penile defects, including erectile dysfunction and peyronie's disease, is provided. The composition includes adipose tissue and stem cells.

06/18/15
20150164064 

Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms


The present invention concerns the use of oxygen antagonists for inducing stasis in cells, tissues, and/or organs in vivo or in an organism overall. It includes methods and apparatuses for achieving stasis in any of these biological materials, so as to preserve and/or protect them.
Fred Hutchinson Cancer Research Center


06/11/15
20150158921 

Alphao-superfamily conotoxin peptide, pharmaceutical composition and use thereof


The present invention pertains to fields of biochemistry and molecular biology, relates to an αo-superfamily conotoxin peptide, pharmaceutical composition thereof, preparation method and use thereof. The present invention further relates to a propeptide of the conotoxin peptide, nucleic acid construct thereof, expression vector and transformed cell thereof, and fusion protein thereof.
Hainan University


06/11/15
20150157583 

Pharmaceutical composition


Pharmaceutical compositions comprising a plurality of ingredients that synergistically provide an antimicrobial, analgesic, or wound healing characteristic.. .

06/11/15
20150157508 

Wound cleansing apparatus with scaffold


An apparatus for cleansing and applying therapy or prophylaxis to wounds, in which irrigant fluid containing a physiologically active material from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing. A biodegradable scaffold underlies the dressing on the wound bed to promote tissue growth.
Smith & Nephew Plc


06/04/15
20150152138 

Uses of kappa opioid synthetic peptide amides


The invention relates to methods of use of synthetic peptide amides that are ligands of the kappa opioid receptor in the treatment and prevention of kappa opioid receptor-associated diseases and conditions; and particularly to uses of these agonists in the prophylaxis, inhibition and treatment of pain, inflammation and pruritis associated with a variety of diseases, disorders and conditions. Inflammatory conditions preventable or treatable by the methods of the invention include diseases and conditions associated with elevated levels of a proinflammatory cytokines, such as tnf-α, il-1β, il-6, mmp-1 and mmp-3.
Cara Therapeutics, Inc.


06/04/15
20150150931 

Method to facilitate healing of wounds


A method for treating wounds utilizing a dry powder mixture created using dry flour. The wound healing dry powder is created through the method of first heating dry flour over heat for a sufficient amount of time to undergo a chemical change wherein the flour changes color.

06/04/15
20150150925 

Wound healing composite with a function of promoting the growth of granulation tissues


A composite with antibacterial and antipruritic functions includes a first substrate extracted from a plant, a second substrate and a base, and the first substrate includes a loniceraiaponica extract and an acanthopanax extract, and both loniceraiaponica extract and acanthopanax extract have a weight percentage ranging from 0.75 to 1.33, and the composite can effectively restrain the itch caused by skin pustules, folliculitis, and mosquito bites, and achieve the moisturization and antipruritic and anti-dander effects for mitigating the symptoms caused by candida albicans and staphylococcus aureus. In addition, this composite has good effects on general skin diseases such as hand eczema (ktpp), eczema, and lip herpes.
Li Tzu Pao Mei Regiman Beauty Public Ltd. Company


06/04/15
20150150924 

Wound healing composite with a function of promoting the growth of granulation tissues


A wound healing composite with a function of promoting the growth of granulation tissues includes a substrate extracted from a plant and a base, and the substrate includes a loniceraiaponica extract, a mugwort extract, and ginkgo, and both loniceraiaponica extract and ginkgo have a weight percentage ranging from 0.28% to 3.5%. The wound healing composite can effectively promote the growth of granulation tissues, and loniceraiaponica, mugwort, ginkgo and other ingredients are extracts of natural plants, and thus the wound healing composite has a low drug resistance and does not have the side effect of drug allergy or the doubt leading to skin cancer..
Li Tzu Pao Mei Regiman Beauty Public Ltd. Company


05/28/15
20150148381 

Substituted dihydropyrazolones for treating cardiovascular and hematological diseases


The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.. .
Bayer Intellectual Property Gmbh


05/28/15
20150148304 

Novel peptides and analogs for use in the treatment of macrophage activation syndrome


Innate defense regulators (idrs) interact with intracellular signaling events and modulate the innate defense response. Whereas much of the initial work with the idrs focused on their role in fighting infection, recent results in animal models of chemotherapy- or radiation-induced mucositis and wound healing suggest that idrs can be beneficial during the responses to a broader range of damage-inducing agents beyond pathogens.
Soligenix, Inc.


05/21/15
20150141501 

Ultrapure tetrahydrocannabinol-11-oic acids


This application is in the field of medicinal chemistry and relates to ultrapure ajulemic acid, its synthesis, pharmaceutical compositions and methods of use thereof for the treatment and/or prevention of inflammation, pain, and fibrotic diseases including scleroderma, systemic sclerosis, scleroderma-like disorders, sine scleroderma, liver cirrhosis, interstitial pulmonary fibrosis, idiopathic pulmonary fibrosis, dupuytren's contracture, keloids, chronic kidney disease, chronic graft rejection, and other scarring-wound healing abnormalities, post-operative adhesions, and reactive fibrosis.. .
Corbus Pharmaceutics Inc.


05/21/15
20150141430 

Method for modulating canonical wnt pathway using folate and inositol


The canonical wnt signaling pathway is implicated in wound healing. Administration of a composition having myo-inositol and folic acid upregulates fibronectin and provides the greatest protection in an additive/synergistic manner against adverse wnt/β-catenin-mediated effects on cell processes relating to cell differentiation, proliferation, and migration that relate to wound healing..
University Of South Florida


05/21/15
20150140138 

Decubitus treatment system


The present invention includes compositions and methods for cleaning, treating, protection and resolution of decubitus ulcers comprising: a first composition comprising a wound cleaning solution comprising aloe vera gel comprising at least 5,000 mps, a balanced salt solution; and a second composition comprising a wound healing gel comprising aloe vera gel comprising at least 10,000 mps, a thickening agent, and one or more preservatives and, optionally, a third composition comprising a moisture barrier cream comprising a vegetable-based emulsifier, a cosmetic ester for dry skin that has low occlusivity, an ester-based emollient that is oxidation stable and has low occlusivity; a beeswax; a hydrogenated oil, glycerin, a buffering agent, aloe vera gel comprising at least 2,000 mps and water.. .
Aloe Bioscience, Llc


05/21/15
20150140116 

Bone implant materials comprising cross-linked bioactive hydrogel matrices


The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices.
Pioneer Surgical Technology, Inc.


05/21/15
20150140064 

Nanoscale collagen particles and membranes


Nano scale collagen particles can be obtained from an embrittling and attrition process that reduces the size of collagen particles to the nano scale. These nano scale collagen particles have many favorable properties such as providing beneficial and enhanced properties for cell seeding and wound healing.
Empire Technology Development Llc


05/21/15
20150140060 

Compositions and methods for promoting wound healing and tissue regeneration


Provided herein are compositions and methods for use in promoting wound healing and tissue regeneration following tissue injury in a subject.. .
Musc Foundation For Research Development


05/21/15
20150139962 

Composition and stem cells for preservation of cardiac tissue


The method and composition may be used in medicine or cosmetic application, in particular, in treatment of cardiac tissue and/or cardiac diseases, and/or in the treatment of wound healing namely diabetic wound healing.. .

05/14/15
20150132805 

Composition for producing microrna precursors as drugs for enhancing wound healing and production the microrna precursors


This invention generally relates to a composition and its production method useful for developing drugs and/or therapies for enhancing wound healing, in particular scarless wound healing. Particularly, the present invention teaches the essential processes necessary for producing and purifying embryonic stem cell (esc)-specific rna compositions, such as messenger rnas (mrna), microrna precursors (pre-mirna), and small hairpin rnas (shrna), which are useful for treating human diseases and lesions..

05/14/15
20150132362 

Hemostatic sponge


The present invention provides a hemostatic porous sponge comprising a matrix of a fibrous biomaterial and particles of a fluid absorbing, particulate material adhered to said matrix material, a method of producing these sponges and their use for wound healing.. .

05/14/15
20150132240 

Topical composition and skin treatment


A topical composition and method for skin treatment including a wound healing agent in combination with a wound concealing agent, is disclosed herein.. .

05/07/15
20150127041 

Handpiece for use in tissue dissection


A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece.
Ulthera, Inc.


05/07/15
20150126447 

Method and kit for the classification and prognosis of wounds


The present invention relates to a method and kit for the classification and prognosis of wounds of mammalian, in particular in human. The method defines a molecular signature that enables one to characterize a pathological wound healing such as chronic or non-healing wound..
Ecole Normale Superieure


04/30/15
20150119788 

Biophotonic compositions, kits and methods


The present disclosure provides biophotonic topical compositions, kits and their uses. In particular, the biophotonic compositions of the present disclosure are substantially resistant to leaching such that very low amounts of chromophore(s) present in the biophotonic composition leach out of the composition.
Klox Technologies Inc.


04/30/15
20150118734 

Inducible gene expression composition for using eukaryotic pol-2 promoter-driven transcription in prokaryotes and the applications thereof


Eukaryotic protein-coding messenger rnas and non-coding micrornas are naturally transcribed by type ii rna polymerases (pol-2) but not prokaryotic rna polymerases. As a result, current eukaryotic rna and protein production is performed either using eukaryotic pol-2 promoters in hybridomas or mammalian cells or using prokaryotic promoters in bacterial cells.
Mello Biotechnology, Inc.


04/23/15
20150110748 

Bone grafts including osteogenic stem cells, and methods relating to the same


Bone grafts and constructs including stem cells are provided. Example bone grafts include osteogenic stem cells seeded on a scaffold of osteoconductive cortico-cancellous chips and/or osteoinductive demineralized bone.
Globus Medical, Inc.


04/23/15
20150110747 

Bone grafts including osteogenic stem cells, and methods relating to the same


Bone grafts and constructs including stem cells are provided. Example bone grafts include osteogenic stem cells seeded on a scaffold of osteoconductive cortico-cancellous chips and/or osteoinductive demineralized bone.

04/16/15
20150105811 

Methods for dissection of subcutaneous tissue


A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece.
Ulthera, Inc.


04/16/15
20150105447 

Fidgetin-like 2 as a target to enhance wound healing


Methods of treating a wound in a subject are provided comprising administering to the subject an amount of an inhibitor of fidgetin-like 2. Compositions and pharmaceutical compositions comprising an amount of an inhibitor of fidgetin-like 2 are also provided.
Albert Einstein College Of Medicine Of Yeshiva University


04/16/15
20150105360 

Therapeutic compositions and method


This invention relates the use of cortisol blockers (glucocorticoid receptor [gr] antagonists) for the prevention or addiction induced anxiety and withdrawal side effects as a therapeutic and in concert with a diagnostic. Such addictions could be, but are not limited to, alcohol, drugs, caffeine, sugar, food, nicotine, etc.
Pop Test Cortisol Llc


04/16/15
20150105319 

Durable haemostatic scaffold


A method for preparing a haemostatic and adhesive durable scaffold useful for promoting wound healing, and the scaffold so prepared, are provided. The scaffold made of fibrinogen and chitosan is produced by electrospinning techniques, resulting in a material with enhanced endurance, applicable in various medical purposes including surgery, tissue regeneration, burns, injuries, and the like.

04/16/15
20150104492 

Esculentin 1a derivatives and uses thereof


The present invention provides synthetic antibacterial peptides comprising a sequence at least 80% identical to a sequence shown in seq id no: 2 or the diastereomer thereof with a sequence shown in seq id no: 3 or pharmaceutical compositions thereof. Also provided are methods for reducing the severity of microbe-induced inflammation and for stimulating wound healing via the synthetic antibacterial peptides.

04/16/15
20150104482 

Use of cpg oligonucleotides co-formulated with an antibiotic to accelerate wound healing


Pharmaceutical compositions are provided that include an antibiotics, but that include ingredients that counteract the effect of that antibiotic on wound healing, without altering the bactericidal properties of the antibiotic. These pharmaceutical compositions include an effective amount of 1) an imidazoquinoline having toll-like receptor 7 (tlr7) ligand activity, 2) an immunostimulatory k-type cpg oligodeoxynucleotide (odn) comprising an unmethylated cpg motif, 3) an antibiotic, and 4) a surfactant, wherein the composition is formulated for topical administration.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv


04/09/15
20150098985 

Wound dressings for the controlled release of therapeutic


A wound dressing material for controlled activation of a wound healing therapeutic compound in the presence of a protease enzyme in a wound fluid, the material comprising: a medically acceptable polymer; a wound healing therapeutic agent; an inhibitor of the protease enzyme; and a linker group which is cleavable by the protease enzyme, wherein the activities of both the wound healing therapeutic agent and the inhibitor are increased by contacting the wound dressing material with a would fluid containing the protease enzyme. For example, the enzyme may be a matrix metalloproteinase, the therapeutic agent may be a reactive oxygen scavenger, and the inhibitor may be a tissue inhibitor of metalloproteinase (timp)..
Systagenix Wound Management (us), Inc.


04/02/15
20150094330 

Compounds and methods for skin repair


The invention provides compositions and methods for wound healing and scar reduction. The compositions and methods of the invention include at least one ep4 agonist set forth herein.
Allergan, Inc.


04/02/15
20150094260 

Buffered ophthalmic compositions and methods of use thereof


The present disclosure provides a buffered ophthalmic composition for formulation of topically administrable suspensions useful for treating eye disorders by promoting wound healing, delivery of pharmaceutically active agents, and lubricating the eye. In particular the ophthalmic composition includes a buffer solution compatible with application to a mammalian eye, wherein the buffer provides increased mechanism of action of pharmaceutically active agents as well as therapeutic qualities.
Arava Bio-tech Ltd.


04/02/15
20150094256 

Use of the cathelicidin ll-37 and derivatives thereof for wound healing


Use of the antimicrobial cathelicidin peptide ii-37, n-terminal fragments of ll-37 or extended sequences of ll-37 having 1-3 amino acids in the c-terminal end, for stimulating proliferation of epithelial and stromal cells and thereby healing of wounds, such as chronic ulcers. The cytotoxic effect of ll-37 may be reduced by including a bilayer-forming polar lipid, especially a digalactosyldiacylglycerol, in pharmaceutical compositions and growth media comprising ll-37..
Lipopeptide Ab


03/26/15
20150088231 

Ocular treatment system and method using red and gold phototherapy


Systems and methods of ophthalmologic or ocular phototherapy treatment are provided herein. In some embodiments, the systems and methods of ophthalmic or ocular phototherapy treatment comprise applying a treatment light beam in a predetermined wavelength or wavelength range corresponding to gold (yellow to orange), red, or at least part of both the gold and red visible light wavelength ranges to at least a portion of an eye.
Cxl Ophthalmics, Llc


03/26/15
20150086605 

Multi-layer biomaterial for tissue regeneration and wound healing


The technology described herein is directed to compositions comprising at least a first porous biomaterial layer and a second impermeable biomaterial layer and methods relating thereto. In some embodiments, the compositions and methods described herein relate to wound healing, e.g.
Tufts University


03/19/15
20150080787 

Apparatus for aspirating, irrigating and cleansing wounds


An apparatus for cleansing wounds in which irrigant fluid from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing. The cleansing means (which may be a single-phase, e.g.
Smith & Nephew Plc


03/19/15
20150080784 

Method and device for treating a tissue with a high frequency electromagnetic field


Methods and systems for treating a tissue with a high frequency electric field to activate mapk/erk pathways, induce angiogenesis, induce angionenic factos such as no and vegf, or promote wound healing. Aspects of the invention are directed to methods of treating chronic wounds such as diabetic ulcers and hypoxia induced wounds.
University Of Cincinnati


03/19/15
20150080659 

Systems and methods for introducing and applying a bandage structure within a body lumen or hollow body organ


Systems and methods provide intraluminal delivery of a bandage structure within a body lumen or hollow body organ, e.g., for treating an injured gastrointestinal tract or an esophageal hemorrhage in a non-invasive way using endoscopic visualization. The systems and methods can be sized and configured to apply a chitosan bandage structure within a body lumen or hollow body organ, to take advantage of the mucoadhesive, antimicrobial, hemostatic, and potential accelerated wound healing properties of the chitosan material..
Providence Health System - Oregon D/b/a Providence St. Vincent Medical Center


03/19/15
20150080314 

Topical corneal analgesia using neurotensin receptor agonists and synergistic neurotensin combinations without delaying wound healing


Ocular analgesics for topical administration are described. The topical ocular analgesic includes a neo-tryptophan-containing neurotensin analog.
Sloan-kettering Institute For Cancer Research


03/19/15
20150080301 

Absorbable polyurethanes and methods of use thereof


Disclosed are novel bioabsorbable and biodegradable monomer compounds, bioabsorbable and biodegradable polymers therefrom, and methods of making such monomers and polymers, which are useful in pharmaceutical delivery systems, tissue engineering applications, tissue adhesives products, implantable medical devices, foams and reticulated foams for wound healing and drug delivery, bone hemostats and bone void fillers, adhesion prevention barriers, meshes, filters, stents, medical device coatings, pharmaceutical drug formulations, consumer product and cosmetic and pharmaceutical packaging, apparel, infusion devices, blood collection tubes and devices, other medical tubes, skin care products, and transdermal drug delivery materials.. .
Bezwada Biomedical, Llc


03/19/15
20150079196 

Wound dressing containing polysaccharides


A wound dressing makes use of polysaccharides, including the formation of a range of variable viscosity mixtures that use a solid polysaccharide such as medical grade cane sugar and a liquid polysaccharide such as honey, both of which have inherent beneficial properties for wound healing. The mixture is applied to an absorbent surface that is designed to absorb the mixed polysaccharide only partially..
Medline Industries, Inc.


03/19/15
20150079152 

Composition and dressing for wound treatment


The invention provides methods and compositions for wound treatment and/or blood clot formation, e.g., arresting the flow of blood from an open wound. The methods and compositions provide for promoting and accelerating wound healing and optionally provide for inhibition of microbial infection and/or a local analgesic effect..

03/19/15
20150079143 

Three-dimensional scaffolds for tissue engineering made by processing complex extracts of natural extracellular matrices


Methods of making a biologically active three-dimensional scaffold capable of supporting growth and differentiation of a cell are described. Biologically active three-dimensional scaffold made by the methods of the invention and an engineered tissue made from the scaffolds are described.
Drexel University


03/19/15
20150079134 

Treatment to promote wound healing


The invention relates to a field of tissue repair and regeneration. More particularly, the invention relates to a composition for promoting cutaneous wound healing.
Rutgers, The State University Of New Jersey


03/12/15
20150073444 

Polyhydroxyalkanoate medical textiles and fibers


Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate.
Tepha, Inc.


03/12/15
20150073326 

Hemostasis wound healing device for dynamic elastic injury site


A topical cooling compressive hemostasis wound healing device and methods thereof for affecting a percutaneous access site wound or an acute surgical wound. The device delivers and transports cooling to affect and control vasculature and musculoskeletal motions surrounding the injury site during the blood coagulation, hemostasis, and wound healing phases.

03/12/15
20150072966 

Method of promoting wound healing


A method of establishing a therapeutic window of wound fluid nitric oxide (wfno) in the wound of a mammal, the method including: obtaining a wound fluid sample from a mammal; analyzing the wfno level; determining whether the wfno is at or below a lower threshold level, or is at or above an upper threshold level; wherein the lower threshold level and upper threshold level define the therapeutic window of wfno; and treating the mammal with a substance that alters the wfno level such that the therapeutic window of wfno in the wound is established.. .
3m Innovative Properties Company


03/12/15
20150072936 

Methods for promoting wound healing and/or reducing scar formation


The present invention provides methods for promoting wound healing and/or reducing scar formation, by administering to an individual in need thereof one or more of the heat shock protein 20-derived polypeptides disclosed herein.. .

03/12/15
20150071869 

Wound healing compositions including cyanoacrylate monomers and phenytoin


A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition.. .
Adhezion Biomedical, Llc


03/12/15
20150071856 

Antagonistic peptides for frizzled-1 and frizzled-2


The invention is in the field of molecular medicine. It provides antagonistic compounds for frizzled-1 and/or frizzled-2 receptors, which may be useful in molecular imaging of the wound healing process after myocardial infarction and in therapeutic intervention into wound healing after remodeling of the heart, thereby ameliorating the consequences of myocardial infarction.
Academisch Ziekenhuis Maastricht


03/12/15
20150068531 

Methods and devices for conduit occlusion


The present invention comprises systems. Methods and devices for the delivery of compositions for occluding or of elements for opening conduits.
Femasys Inc.


03/05/15
20150066011 

Devices and methods for performing subcutaneous surgery


Devices and methods for performing subcutaneous surgery in a minimally invasive manner are provided. The methods include application of reduced air pressure in a recessed area of a handpiece placed over a section of skin and drawing the section of skin and subcutaneous tissue into the recessed area.
Ulthera, Inc.


03/05/15
20150065453 

Combination of an oxidant and a photoactivator for the healing of wounds


There is provided a wound healing composition which comprises at least one oxidant, at least one photoactivator capable of activating the oxidant and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin in association with a pharmaceutically acceptable carrier. In addition, a method of topically treating wounds using at least one oxidant and at least one photoactivator capable of activating the oxidant followed by illumination of said photosensitizer is disclosed..
Klox Technologies Inc.


03/05/15
20150065429 

Crosslinked human or animal tissue products and their methods of manufacture and use


Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material.
Harbor Medtech, Inc.


03/05/15
20150065428 

Method for articular cartilage and joint formation


The invention is a method of applying a joint inducing protein preferably bmp-9 or bmp-3 to an ossification center in order to create a joint, articular cartilage, or an endochondral cap. The ossification center may be one that occurs naturally such as in the case of amputation, wound healing or fracture, or, it may be artificially induced by the application of an ossification center inducing protein, which may include other bmp family proteins such as bmp-2, bmp-4 or bmp-7.

03/05/15
20150064771 

Inducible gene expression composition for using eukaryotic pol-2 promoter-driven transcription in prokaryotes and the applications thereof


Eukaryotic protein-coding messenger rnas and non-coding micrornas are naturally transcribed by type ii rna polymerases (pol-2) but not prokaryotic rna polymerases. As a result, current eukaryotic rna and protein production is performed either using eukaryotic pol-2 promoters in hybridomas or mammalian cells or using prokaryotic promoters in bacterial cells.
Mello Biotechnology, Inc.


03/05/15
20150064129 

Wound healing composition


The invention discloses a composition comprising hyaluronic acid with a high molecular weight and povidone-iodine in low amount that has advantageous efficacy in enhancing wound healing and maintains high stability. Also disclosed is a method of using the composition of the invention in healing wounds..
Taiwan Biotech Co., Ltd.


02/26/15
20150057216 

Angiotensins for treatment of fibrosis


The present invention provides, among other things, methods and compositions for treating or preventing fibrotic diseases, disorders or conditions based on angiotensin (1-7) polypeptides, and analogs or derivatives thereof. In some embodiments, compositions and methods for treating or preventing pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease (copd), asthma, cystic fibrosis, kidney fibrosis, liver fibrosis, systemic sclerosis, post-surgical adhesions, accelerating wound healing, and reducing or preventing scar formation are provided..
Tarix Pharmaceuticals Ltd.


02/19/15
20150050717 

Bacteriophages expressing antimicrobial peptides and uses thereof


The present invention is generally related to engineered bacteriophages expressing antimicrobial peptides or lytic enzymes or fragments thereof for targeting a broad spectrum of bacterial hosts, and for the long-term suppression of bacterial phage resistance for reducing bacterial infections. In some embodiments, bacteriophages express antimicrobial peptides or antimicrobial polypeptides (e.g.
Trustees Of Boston University


02/19/15
20150050359 

Decellularisation of tissue matrices for bladder implantation


The invention provides an improved method of producing a natural, acellular matrix scaffold for subsequent use in tissue-engineered replacement of tissues such as the bladder. Decellularisation is carried out on an expanded or distended bladder and the product retains the strength and compliance of natural material.
Tissue Regenix Limited




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Wound Healing topics: Wound Healing, Amino Acid, Amino Acid Sequence, Proliferation, Theophylline, Inflammation, Antimicrobial, Epithelial, Amino Acids, Skin Graft, Bone Healing, Vascular Disease, Skin Ulcer, Bacterial Infection, Dysfunction

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