 Patent Application Title |
Patent App Num. |
Date |
| Virally-inactivated growth factors-containing platelet lysate depleted of pdgf and vegf and preparation method thereof | 20130143810 | 20130606 |
 The invention concerns human platelet extracts rich in growth factors (PGF) for wound healing and stem cell expansion. Accordingly the subject invention relates to a virally-inactivated growth factors-containing platelet lysate depleted of PDGF and VEGF, which is preferably enriched in TGF, IGF and EGF-rich. The present invention further concerns a method for obtaining a platelet lysate comprising the steps of contacting a starting platelet concentrate with a solvent and/or a detergent, incubating the starting platelet concentrate with the solvent and/or detergent for a period of at least 5 minutes to 6 hours, at a pH maintained in a range from about 6.0 to about 9.0, and at a temperature within the range of from 2° C. to 50° C., optionally removing the solvent and/or the detergent... |
| Impaired wound healing compositions and methods | 20130143952 | 20130606 |
 Connexin modulation for the treatment of wounds that do not heal at expected rates, including delayed healing wounds, incompletely healing wounds, and chronic wounds, and associated methods, compositions and articles.
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| Wound healing compositions based on cyanoacrylates and 5,5-disubstitutedhydantoins, including phenytoin | 20130136715 | 20130530 |
 A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition.
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| Bone matrix compositions and methods | 20130136777 | 20130530 |
 Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been... |
| Compound used to prevent diseases caused by aquaporin deficiency | 20130137766 | 20130530 |
 A compound used to prevent diseases caused by aquaporin deficiency, which is 18β-Glycyrrhetinic acid derivative. Said compound can not only prevent diseases caused aquaporin deficiency, but be able to prevent aquaporin (AQP) production and enhance skin function. Since AQPs have many advantages in skin cells, e.g. promoting water and glycerine molecular transportation, increasing skin elasticity and cuticle moisture, increasing the cell proliferation and cell migration, aquaporin can promote skin bather function and wound cicatrization. Therefore, said compound can be applied potentially as a medicinal cosmetic in skin medicine cosmetology, or as a new medical composition to treat diseases caused by AQP abnormality, such as urine concentration defect, wound healing slow down, corneal re-epithelialization slow down and etc.
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| Preservative-free composition for topical use including hyaluronic acid | 20130129844 | 20130523 |
| The present invention relates to a sterile and/or decontaminated composition for topical use, including hyaluronic acid at a concentration of greater than or equal to 0.1 wt % relative to the total weight of the composition, at least one skin wound healing agent, optionally at least one plant extract, and at least one solvent. The invention also relates to a unit including such a composition, to a method for preparing such a composition, and to the uses thereof.
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| Antibody mediated osseous regeneration | 20130122052 | 20130516 |
| The invention relates to the field of immunologically reactive molecules used to improve implantable medical devices. Immobilization of selected antibody molecules onto the surface of medical implants enable localization and concentration of in vivo growth factors in a timely manner to enhance the wound healing process following implantation of the device. When in vivo BMP-2 growth factor was captured on an implant device by attached monoclonal antibodies, the biological activity of BMP-2 was enhanced in the vicinity of the implant device. BMP-2 growth factor-specific antibody molecules or their fragments when immobilized on titanium dental or orthopedic implants improve osseo-integration.
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| Drug delivery devices and growth factor formulations for accelerated wound healing | 20130122066 | 20130516 |
| The present invention is directed to novel drug delivery devices and pharmaceutical compositions containing growth and differentiation factor proteins. Said devices and compositions are specifically designed to accelerate tissue regeneration and wound healing processes of mammalian tissues. The invention is especially useful for the supportive therapy of diabetic wounds and ulcers.
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| Dissection handpiece and method for reducing the appearance of cellulite | 20130123767 | 20130516 |
| A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.
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| Dissection handpiece and method for reducing the appearance of cellulite | 20130123771 | 20130516 |
| A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.
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| Light-emitting devices for wound healing | 20130103123 | 20130425 |
| Methods and devices related to wound healing using phototherapy are described. Some embodiments provide an organic light-emitting diode device, such as a light-emitting device for phototherapy, comprising Ring System 1, Ring System 2, Ring System 3, Ring System 4 or Ring System 5.
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| Stem cell secreted product derived compositions for wound treatment | 20130089514 | 20130411 |
| Compositions including formulations comprising secreted products obtained from the culture medium of stem cells, such as umbilical cord blood stem cells, or embryonic germ cell derivatives, or embryonic stem cells, are provided for enhancement of wound healing. Further compositions contain components identified in such culture medium to enhance wound healing. Methods for using the compositions and formulations for enhancing wound healing are also provided. Wounds to both soft and bony tissues are encompassed, and include wounds created by surgical procedures.
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| Compositions and methods for platelet enriched fibrin constructs | 20130084310 | 20130404 |
| Compositions and methods are provided for tissue constructs that promote wound healing. The composition comprises a dimensionally stable fibrin construct for local administration to a wound site or region. In one embodiment, the fibrin construct is a wound healing composition, including components that promote wound healing, such as platelets, growth factors, white blood cells and fibrin clots. In another embodiment, the tissue treatment composition includes (i) aggregated fibrin, (ii) blood cells, and (iii) optionally, growth factors and/or other proteins.
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| Method and mixture for treating and preventing inflammatory bowel disease | 20130085118 | 20130404 |
| A method and a mixture for treating and preventing the inflammatory bowel disease (IBD) by applying a predetermined therapeutically effective amount of a mixture of hyaluronic acid to individuals is disclosed. The mixture includes at least two different average molecular weight hyaluronic acids (Mw) with different rheology to gain a hyaluronic acid with the proper adhesion property, functions of tissue scaffold and insulation and treatment time, in order to treat and to prevent IBD (inflammatory bowel disease) includes ulcerative colitis, Crohn's disease or wound healing in stomach and intestine, thus to achieve the prompt treatment and to prolong the effect.
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| Perforated bioabsorbable oil film and methods for making the same | 20130074452 | 20130328 |
| A bio-absorbable stand-alone film is derived at least in part from fatty acids. The bio-absorbable stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. The stand-alone film has one or more perforations or depressions formed therein. Corresponding methods of making the bio-absorbable stand-alone film with one or more perforations or depressions include molding, cutting, carving, puncturing or otherwise suitable methods to create the perforations or depressions in the bio-absorbable stand-alone film. The resulting stand-alone film is bioabsorbable.
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| Novel systems, vectors, and methods for delivery of biomolecules to eukaryotic cells | 20130078275 | 20130328 |
| Embodiments described herein provide novel bacterial-based methods, systems, and delivery vehicles capable of delivering DNA, RNA, proteins, and other cargo into targeted mammalian cells, both in vitro and in vivo, with high efficiency. Delivery vehicles may be used to deliver molecules such as prophylactic or therapeutic proteins, DNA, shRNA, DNA vaccines, mucosal vaccines, modified viruses or viral components, and other bioactive molecules. Potential applications include gene therapy, wound healing therapies, cancer therapy, immune modulation, and research applications for which delivery of DNA, RNA, proteins, or other cargo into mammalian cells and tissues is required.
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| Wound healing device | 20130071457 | 20130321 |
| The invention is directed to a wound healing device. Such wound healing device utilizes novel wound healing compositions embedded onto or into a natural plant-derived cloth-based matrix.
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| Extract of stewartia koreana and use thereof | 20130071501 | 20130321 |
| The present invention relates to an extract of Stewartia koreana and use thereof More particularly, it relates to an extract of Stewartia koreana which is extracted with any one selected from the group consisting of water, a C1-4 low alcohol, a polar solvent, a non-polar solvent and a mixture thereof, and a pharmaceutical composition for promoting angiogenesis or tissue regeneration and a cosmetic for improving wrinkles comprising the same as an effective ingredient. The extract of Stewartia koreana promotes migration and multiplication of endothelial cell and shows excellent effect in angiogenesis and wound healing and is useful in treatment or prevention of diseases which requires angiogenesis for healing of wounded and frostbitten region, wound healing after surgical operation, and treatment and prevention of gastric ulcer, ischaemic... |
| Methods and devices to accelerate wound healing in thoracic anastomosis applications | 20130072910 | 20130321 |
| A minimally invasive lung reduction device which overcomes the disadvantages associated with treating chronic obstructive pulmonary disease by utilizing the phenomenon of collateral ventilation to increase the expiratory flow from a diseased lung. The device also provides a means for assisting in or facilitating pulmonary decompression to compress the diseased area or area of the lung or lungs to a smaller volume.
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| Skin wound closure apparatus | 20130072969 | 20130321 |
| The invention discloses a skin wound closure device capable of promoting skin wound healing and characterized by being capable of randomly adjusting stitching force for a wound. The skin wound closure device includes a support structure respectively arranged at both sides of a skin wound, at least one locking device is arranged above the support structure, the locking device includes a locking bar and a locking buckle arranged on the support structure, the locking bar is movably connected within the locking buckle, and a locking member is arranged on the locking buckle and can lock or loosely fit the locking bar in the locking buckle. Arrangement of the locking member allows doctors to loosely fit the locking bar in the locking buckle by controlling the locking... |
| Methods and compositions for maintenance of a functional wound | 20130064774 | 20130314 |
| The present invention relates to methods and compositions for the modulation of wound healing and/or the production of extracellular membrane components by modulating the activity and/or amount of secreted protein acidic and rich in cysteine (SPARC) protein. The invention further provides methods for identifying compounds useful in the above-mentioned methods and compositions.
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| Method and formulation for treating dry ear inflammation with cortisone | 20130064911 | 20130314 |
| The present invention provides a method and formulation for treating and preventing asteatosis or “dry ear” symptoms and inflammation. The method of the present invention comprises topically applying to the ear canal a semi-viscous diglycerin and butylene glycol polyhydroxy liquid formulation including hydrocortisone, a natural product anti-irritant, a wound healing agent, and an anti-inflammatory agent, stabilized with a cationic surfactant and a nonionic surfactant.
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| Methods and compositions for enhancing wound healing using car peptides | 20130058993 | 20130307 |
| Disclosed are compositions and methods useful for treating wounded, injured, and inflamed tissue. The compositions and methods are based on peptide sequences, such as CAR peptides and truncated CAR peptides, that are selectively targeted to wounded tissue and are internalized by a cell, penetrate tissue, or both. The disclosed peptides promote and enhance wound healing.
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| Biomedical materials for tissue engineering | 20130059382 | 20130307 |
| In an embodiment of the disclosure, a biomedical material is provided. The biomedical material includes a biocompatible material having a surface and a carrier distributed over the surface of the biocompatible material, wherein both of the biocompatible material and the carrier have no charges, one of them has charges or both of them have charges with different electricity. The biomedical material is utilized for dentistry, orthopedics, wound healing or medical beauty and applied in the repair and regeneration of various soft and hard tissues.
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| Phospholipid-enriched vesicles bearing tissue factor having haemostatic activities and uses thereof | 20130059782 | 20130307 |
| The invention relates to a method for improving the procoagulant properties of TF expressed in eukaryotic cells by contacting microvesicles derived from said eukaryotic cells with a negatively-charged phospholipid such as phosphatidylserine. The invention also relates to microvesicles obtained using said method as well as to the uses thereof as procoagulant agents, for wound healing and for promoting angiogenesis.
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| Quantitative image analysis for wound healing assay | 20130051651 | 20130228 |
| Illustrative embodiments of a method are disclosed, which comprise applying a texture filter to a bright field image of a wound healing assay, generating a wound mask image in response to an output of the texture filter, and determining a wound area of the wound healing assay by counting a number of pixels in the wound mask image corresponding to the wound area. Illustrative embodiments of apparatus are also disclosed.
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| Method for preparing polymeric biomaterials having immobilized drug delivery system comprising bioactive molecules loaded particle carrier | 20130045266 | 20130221 |
| A new polymeric material for biological tissue regeneration or treatment with a drug delivery system which contains therapeutic agents and/or bioactive molecules to reduce infection and inflammatory reaction at a wound site and maximize tissue regeneration and wound healing is provided. The new bioactive molecule-loaded polymeric material is prepared by (1) preparing micrometer or nanometer sized bioactive molecule-loaded particles; (2) modifying the surface of the prepared particles and immobilizing the particles on the surface of the polymeric material; and (3) physically treating the surface of the polymeric material to improve binding strength of the particles immobilized thereon.
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| Pro-angiogenic fragments of prominin-1 and uses thereof | 20130045922 | 20130221 |
| Described have herein are peptide analogs of a prominin-1 peptide, DRVQRQTTTVVA (SEQ. ID. NO:1) which have enhanced regenerative and/or angiogenesis activity, increase VEGF binding to endothelial cells, and/or increase wound healing activity relative to the peptide of SEQ ID NO: 1. Provided herein are fusion proteins and compositions comprising these pep tide analogs and uses thereof.
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| Methods of treatment using 3-bromopyruvate and other selective inhibitors of atp production | 20130046019 | 20130221 |
| The present invention provides methods for preventing or treating infections, especially bacterial infections, by administering selective inhibitors of ATP production to inhibit glycolytic enzymes, such as glyceraldehyde 3-phosphate dehydrogenase (GAPDH). As such, the present invention further provides methods for preventing or treating inflammation and sepsis associated with infections, as well as increased wound healing and decreased wound scarring.
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| Promotion of wound healing | 20130040953 | 20130214 |
| The present invention provides compositions and methods that promote wound healing in a subject with a cutaneous injury. In particular, the present invention provides systemic and/or local administration of one or more compositions that cause ganglioside depletion (e.g., glucosylceramide synthase (GCS) inhibitors) for the treatment of cutaneous wounds.
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