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This page is updated frequently with new Wound Healing-related patent applications.




Date/App# patent app List of recent Wound Healing-related patents
07/21/16
20160208258 
new patent Mir-92 inhibitors and uses thereof
The present invention provides oligonucleotide inhibitors of mir-92 and methods of using said inhibitors for inhibiting the function and/or activity of mir-92 in a subject in need thereof. The present invention also provides methods for evaluating or monitoring the efficacy of a therapeutic for promoting wound healing and selecting a subject for treatment with a therapeutic that modulates mir-92 function and/or activity..
Miragen Therapeutics, Inc.


07/21/16
20160206792 
new patent Self adhering suction port pad securement device for use with a negative pressure wound healing drape or dressing
A securement device may have a release strip, a release layer, a film having an adhesive and/or a back layer. The release strip and/or the release layer may be removable from the adhesive.
George Medical, Llc


07/21/16
20160206783 
new patent Cross-linked platelet material
This document provides methods and materials involved in making and using cross-linked platelet material (e.g., cross-linked lysate material from human platelets such as human platelets obtained from platelet blood collection preparations or platelet apheresis preparations). For example, methods and materials for cross-linking platelet material (e.g., lysate material obtained from human platelets) to form a matrix (e.g.
Mayo Foundation For Medical Education And Research


07/21/16
20160206755 
new patent Use of nucleic acids with reduced pressure therapy
Provided is a method of treating a wound site. Also provided is a system for treating a wound site.
Kci Licensing, Inc.


07/21/16
20160206620 
new patent Purin derivatives for use in the treatment of fab-related diseases
The present invention relates to the finding that certain dpp-4 inhibitors are particularly suitable for wound healing preferably in diabetic patients.. .
Boehringer Ingelheim International Gmbh


07/14/16
20160199530 
Bioresorbable wound dressing
The present invention is directed to novel non-woven fabrics containing growth and differentiation factor proteins. Said fabrics are specifically designed to accelerate tissue regeneration and wound healing processes of mammalian tissues.
Carl Freudenberg Kg


07/14/16
20160199447 
Lipid nanoparticles for wound healing
The present invention refers to lipid nanoparticles comprising a growth factor and/or an antimicrobial peptide and to the method for their preparation. Moreover, it refers to pharmaceutical compositions comprising such lipid nanoparticles, and a pharmaceutical acceptable carrier.
Praxis Biopharma Research Institute


07/14/16
20160199343 
Compounds and formulations for the treatment of wounds
The present invention relates to the treatment of wounds. More particularly, it relates to compounds according to formula (1) for use in methods of promoting wound healing, to formulations which incorporate these compounds and to a method of treating wounds using such compounds and formulations: wherein r1 and r2 may be the same or different and are selected from the group consisting of hydrogen (h) and a physiologically hydrolysable chemical group consisting of alkyl, alkyl carbonyl, alkenylcarbonyl arylcarbonyl, heteroarylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, alkylether, alkenylether, arylether, and heteroarylether groups wherein the alkyl group or moiety consists of unsubstituted or substituted, straight-chain or branched-chain and cyclic alkyl groups having 2-22 carbon atoms, wherein the alkenyl moiety consists of unsubstituted and substituted, straight-chain or branched-chain and cyclic alkenyl groups having 2-22 carbon atoms, wherein the aryl moiety consists of unsubstituted and substituted phenyl, and phenalkyl groups wherein the alkyl moiety contains 1-3 carbon atoms and the phenyl moiety is unsubstituted or substituted, and the heteroaryl moiety is an aromatic 5- or 6-membered heterocyclic ring containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen, and sulphur..
Nitto Denko Corporation


07/07/16
20160193293 
Ointment containing a hydrolyzed fibroin and manufacturing same
Embodiments of the present invention provide a topical agent that is a preparation containing hydrolyzed silk. The topical agent is applied to a wound site for use in wound healing, an thus, an object thereof being to have an effect of promoting wound healing and to satisfy practical application conditions with regard to an irritative property, stability, handling ease, and the like.
Kagoshima University


07/07/16
20160193139 
Composition having a. paniculata for wound healing and skin whitening, and method by using the same
The present invention provides a pharmaceutical composition for wound healing and/or skin whitening. The pharmaceutical composition comprises active ingredient of andrographis paniculata extract and/or andrographolide and a pharmaceutical acceptable carrier.
National Dong Hua University


06/30/16
20160184575 

Wound healing electrode set


The set for the electrical stimulation of a patient, comprises a backing, at least one electrically active zone and a wire connected to said electrically active zone for connection to a stimulator. Said backing has the shape of a bandage or of a plaster..

06/30/16
20160184385 

Novel peptide having ability to synthesize collagen and use thereof


Provided are a cosmetic composition and pharmaceutical composition for wound healing capable of efficiently performing collagen synthesis in skin, wherein the compositions contain, as an active ingredient, yigsr peptide having the amino acid sequence of seq id no: 1 or a peptide derivative having a palmitoyl group added to an n-terminal of the peptide.. .

06/30/16
20160184363 

Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids


The present invention relates to the fields of medicine, cell biology, molecular biology and genetics. In particular, the present invention provides methods to isolate and purify microvesicles from cell culture supernatants and biological fluids.

06/30/16
20160184357 

Methods and compositions for promoting wound healing


The present invention provides methods and compositions that use the combination of tris and edta to inhibit the growth of microorganisms at the site of a wound or burn, and/or to promote the healing of a wound or burn, and/or to reduce the sensation of pain at the site of a wound or burn. The amount of tris and edta applied to a wound or burn can be selected to achieve one or more of the foregoing effects..

06/30/16
20160184338 

Bioactive alkaloid compositions and their medical uses


The present invention relates to a novel alkaloid and novel bioactive alkaloid fractions derivable from ribes preferably selected among ribes rubrum and ribes nigrum; methods of manufacturing such bioactive ribes alkaloid fractions and their use for the inhibition of ikk-β, pde4 and/or pde5 and in addition their promoting effect on mitochondrial biogenesis and function; their therapeutic or non-therapeutic applications as nutritive or medicinal products in the management of conditions associated with impaired mitochondrial function or ikk-β, pde4 and/or pde5 activity, such as inflammation, neurodegeneration, dyslipidemia, type 2 diabetes mellitus, impaired wound healing, sarcopenia and other conditions associated with muscle dysfunction or tiredness and fatigue, or where optimization of muscular or cognitive function is desired; extracts, juices or concentrates of ribes comprising such alkaloids; compositions comprising such alkaloids, including pharmaceutical compositions, nutritive product such as functional foods and nutraceutical compositions, and cosmetic compositions and medical devices.. .

06/30/16
20160184139 

Method for wound infection prevention


A wound healing device and method that greatly reduces the risk of infection of an incision or wound by removing fluid from the subcutaneous layers of the skin. The wound healing device includes a first portion that is positioned external of, and on top of, the wound.

06/30/16
20160184138 

Apparatus for wound infection prevention


A wound healing device and method that greatly reduces the risk of infection of an incision or wound by removing fluid from the subcutaneous layers of the skin. The wound healing device includes a first portion that is positioned external of, and on top of, the wound.

06/23/16
20160175579 

Method and improved wound healing


A pad for electrically stimulated wound healing, including a pad configured to be placed on a wound, at least one anode disposed on the pad to contact the wound, and at least one cathode disposed on the pad to contact the wound, the at least one cathode being disposed separately from the at least on anode. The pad wherein the at least one anode and the at least one cathode in contact with the wound provide a flow of electrical current in an intended direction through the wound based on the separate locations of the at least one anode and the at least one cathode..

06/23/16
20160175485 

Combination therapy to promote wound healing


Methods for increasing and/or promoting wound healing, wound re-epithelialization and dermal regeneration of epithelial tissues and cutaneous wounds by administration to a subject of an extracellular matrix scaffold or scaffold for dermal regeneration (sdr) populated with beta adrenergic receptor antagonist pre-conditioned mesenchymal stem cells (mscs) are provided. Compositions and kits comprising an extracellular matrix scaffold (ecms) populated with beta adrenergic receptor antagonist pre-conditioned mesenchymal stem cells (mscs) are also provided..

06/23/16
20160175343 

Polymers and methods thereof for wound healing


Wherein y is 1 or more. Other embodiments of the invention provide a therapeutic method for treating a wound in an animal comprising administering to an animal in need of such therapy, an effective amount of a copolymer as described herein..

06/23/16
20160175158 

Method for wound infection prevention


A wound healing device and method that greatly reduces the risk of infection of an incision or wound by removing fluid from the subcutaneous layers of the skin. The wound healing device includes a first portion that is positioned external of, and on top of, the wound.

06/16/16
20160166725 

Pendant hydrophile bearing biodegradable compositions and related devices


A composition comprising at least one polymer having the structure a-b-a′, wherein a and a′ may be the same or different and each is a degradable polyester component and wherein b is the reaction product resulting from the reaction between a diol, having one or more pendant oligomeric or polymeric groups, and a and a′. Additionally, a bioresorbable patch comprising: (a) an adhesion barrier component comprising the composition in the form of a film; and (b) an adhesive component comprising (i) at least one synthetic adhesive polymer and/or (ii) at least one polysaccharide.
Dsm Ip Assets B.v.


06/09/16
20160161469 

Synthetic microfluidic systems for wound healing


A method of assaying wound healing can include: growing cells on the matrix in the first flow channel; introducing an agent that removes the matrix from the junction; introducing a matrix material into the second flow channel so as to form the second matrix in the second flow channel and junction; and detecting cellular migration into the junction onto the second matrix. The agent that removes the matrix can include a biomolecule or chemical agent.
Cfd Research Corporation


06/09/16
20160160214 

Formulations comprising antisense nucleotides to connexins


A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin protein together with a pharmaceutically acceptable carrier or vehicle is useful in site specific down regulation of connexin protein expression, particularly in reduction of neuronal cells death, wound healing, reduction of inflammation, decrease of scar formation and skin rejuvenation and thickening.. .
Coda Therapeutics, Inc.


06/09/16
20160158411 

Protein biomaterials and biocoacervates and methods of making and using thereof


The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention relates to protein biocoacervates and biomaterials that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, coated medical devices (e.g.
Gel-del Technologies, Inc.


06/09/16
20160158403 

A wound dressing


The present invention relates to an impregnated wound dressing having an outer membrane overlay layer and to a method of production thereof. In particular the dressing comprises a core layer that has been impregnated with a wound healing agent, such as honey, and an outer membrane overlay layer..
Manukamed Limited


06/09/16
20160158370 

Wound healing using topical systems and methods


The present invention generally relates to compositions and methods for topical or transdermal delivery and treatment of wounds and/or promoting wound healing. In some cases, the composition may include nitric oxide and/or peptides.
Transdermal Biotechnology, Inc.


06/09/16
20160158284 

Laser assisted wound healing protocol and system


A method of treating gum disease while healing the wound in the periodontium using a soft tissue diode laser which generates a beam of light having a wavelength in the visible portion of the electromagnetic spectrum (400 nm-700 nm) at a laser power of 0.001 to 1.2 watts, used with intermittent stops to control tissue temperature and biostimulate the periodontium to regenerate and heal its wound when used with substrates, the method comprising: placing the tip of the laser inside the sulcus; penetrating the entire sulcus by moving the laser light circumferentially around the tooth vertically and horizontally throughout the sulcus with intermittent stops to control tissue temperature and placing substrates in the sulcus prior to blood clot formation; followed by rf treatment of the sulcus by placing the rf headpiece tips perpendicular to the sulcus to receive rf current which further penetrates the wound site.. .
Bioregentech


06/09/16
20160158066 

Negative pressure wound dressing


A negative pressure wound dressing is provided. The negative pressure wound dressing sequentially includes a backing layer, a water blocking layer, an absorbent layer and a wound contacting layer.
Benq Materials Corporation


06/02/16
20160151448 

Multimeric tie 2 agonists and uses thereof in stimulating angiogenesis


The present invention provides a multimeric form of a tie 2 binding peptide monomer, wherein the multimeric form has tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates angiogenesis and promotes wound healing.
Sunnybrook Health Sciences Centre


06/02/16
20160151424 

Amniotic membrane preparations and purified compositions and anti-inflammation methods


Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating tgf β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues.
Tissuetech, Inc.


05/26/16
20160144075 

Bone matrix compositions and methods


Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity.
Warsaw Orthopedic, Inc.


05/19/16
20160137968 

Tissue culture testing systems and methods of use


Embodiments of the present disclosure provide materials and methods relating to cell and tissue culture testing systems. Certain embodiments of the present disclosure relate to in vitro testing systems that are useful for performing experiments to investigate the potential for various factors to reduce bioburden, reduce the manifestations of infection, and to promote wound healing in cultured cells and tissues.
Barry University


05/19/16
20160136364 

Nitric oxide delivery system and methods of use


Embodiments of the present disclosure provide systems and devices for delivering gaseous nitrous oxide (gno) under therapeutic parameters to reduce infection in a subject. Certain embodiments include devices and systems for delivering pressurized gno to reduce bioburden and promote healing in the wounds of subjects having various disease conditions, including skin and soft tissue infections (sstis) and osteomyelitis.
Barry University


05/19/16
20160136324 

Biological film-forming agent for facilitation of wound healing and coating and protection of biological organs


The present invention relates to a biological film-forming agent which is for facilitating wound healing and coating and protecting biological organs, and for coating and protecting damaged cells, wound surfaces, organs and damaged sites of organs, and wound surfaces reaching soft tissues such as muscle and facia, periosteum or bone cortex. Provided is a biological film-forming agent for suppressing exudation of intracellular fluid from damaged cells, suppressing expansion of inflammation reactions and secondary inflammation reactions resulting from production of fibrin and eliminating adverse effects caused by formation of stabilised fibrin on healing.
Lilac Laboratory Co., Ltd.


05/12/16
20160129051 

Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment


Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating tgf β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues.
Tissuetech, Inc.


05/12/16
20160129050 

Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition


Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating tgf β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues.
Tissuetech, Inc.


05/12/16
20160129049 

Purified amniotic membrane compositions and methods of use


Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating tgf β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues.
Tissuetech, Inc.


05/12/16
20160129043 

Composition of mesenchymal stem cells


This invention relates in general to a mesenchymal stem cell (msc) therapy. This invention further relates to the isolation and applications of gingiva derived mesenchymal stem cells.
University Of Southern California


05/05/16
20160120821 

Drug eluting silicone gel sheeting for wound healing and scar reduction


Provided are methods of making devices that can be applied to the skin to promote healing of wounds and the reduction or prevention of scarring. The devices include compositions of various silicone compounds loaded with active pharmaceutical agents..
Allergan, Inc.


05/05/16
20160120525 

Devices and methods for closing tissue openings


A medical device to assist surgical procedures by ensuring a controlled incision and a fast and non-invasive wound closure. The device may comprise two sections, each of which comprises a plurality of plates for adhering the device to the skin.
Zhip Meditech, Inc.


04/21/16
20160106801 

Wound healing agent


The present invention aims to provide a wound healing agent that inhibits bacterial growth, promotes granulation tissue formation and epithelization, and minimizes foreign body reaction in the granulation tissue. The wound healing agent of the present invention contains protein (a) and water, wherein the protein (a) contains: gagags (1); and an amino acid sequence (x) and/or an amino acid sequence (x′), and the total percentage of β turns and random coils in the protein (a) as determined by circular dichroism spectroscopy is 60 to 85%, and the percentage of the total number of amino acid residues in the amino acid sequences (x) and (x′) is 50 to 70% of the total number of amino acid residues in the protein (a).

04/21/16
20160106782 

Wound healing and tissue engineering


The present invention is directed to wound healing scaffolds cografted with a population of stem cells, wherein the population of stem cells are abcb5+ stem cells. The scaffolds are, for instance, collagen glycosaminoglycan scaffolds..

04/21/16
20160106715 

Methods to inhibit infection during wound healing with topical compositions including amino acids


A method that inhibits infection during wound healing by topical application of a single composition, which contacts a wound for a period of time to initiate wound healing. The single composition may include a mixture of all or some of the amino acids including: histidine monohydrochloride monohydrate; isoleucine; leucine; lysine acetate; methionine; phenylalanine; threonine; tryptophan; valine; alanine; arginine acetate; aspartic acid; glutamine; glycine; proline; serine; and tyrosine, which may provide aqueous mixtures of a range of osmolarities or a powdered mixture of amino acids.

04/21/16
20160106710 

Wound healing via autologous stem cell mobilization


The present invention relates to the field of wound healing. More specifically, the present invention provides methods and compositions useful for improved wound healing via autologous stem cell mobilization.

04/21/16
20160106594 

Combination sis and vacuum bandage and method


A wound care bandage for treating a wound is provided. The bandage includes an sis layer to be placed on the wound surface and a cover to placed over the wound.

04/14/16
20160102134 

Crosslinked human or animal tissue products and their methods of manufacture and use


Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material.

04/14/16
20160101282 

An arrangement for facilitating wound healing, a measuring wound healing and a wound dressing


The present invention relates to the field of electrotherapy and measuring by means of electric currents for diagnostic purposes, and more particularly to an electrode arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing having an electrode arrangement. A wound dressing according to the present invention comprises at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying lidc type electrical stimulation current to the wound area and for bioimpedance measurement.

04/07/16
20160095929 

Promotion of wound healing


The present invention provides compositions and methods that promote wound healing in a subject with a cutaneous injury. In particular, the present invention provides systemic and/or local administration of one or more compositions that cause ganglioside depletion (e.g., glucosylceramide synthase (gcs) inhibitors) for the treatment of cutaneous wounds..
Northwestern University


03/31/16
20160089477 

Porous foams derived from extracellular matrix, porous foam ecm medical devices, and methods of use and making thereof


The invention disclosed herein is directed to a porous wound healing foam composition that is made from an extracellular matrix of a mammal, method of making, and method of using.. .
Acell, Inc.


03/31/16
20160089420 

Activated leukocyte conditioned supernatant and uses for wound healing


Disclosed are therapeutic, activated leukocyte conditioned supernatants, methods of making them, and methods of using the conditioned supernatants to repair or promote healing of wounds.. .
Macrocure Ltd.


03/24/16
20160083757 

Enzymatic process for the production of mannosylerythritol lipids from lignocellulosic materials


The present invention relates to processes for the production of microbial glycolipids, mannosylerythritol lipids (mel), from lignocellulosic carbon source. These processes are characterized in that the use of lignocellulosic materials for the production of a microbial glycolipids, mel, comprising a fermentation preferably using fungi of the genus pseudozyma or other microorganisms such as genetically modified fungi or bacteria.
LaboratÓrio Nacional De Energia E Geologia


03/24/16
20160082238 

Apparatus and methods for controlling tissue oxygenation for wound healing and promoting tissue viability


A wound treatment system includes a housing. A processor is located in the housing.
Electrochemical Oxygen Concepts, Inc.


03/24/16
20160082146 

Composition for use in wound healing in burns


The preset invention relates to a new method for wound healing, particularly in burns, comprising epinecidin-1 (epi-1) or pardaxin (ge33), optionally in the incorporation into collagen.. .
Academia Sinica


03/24/16
20160082020 

Methods and compositions for stimulating reepithelialisation during wound healing


The present invention relates to methods and compositions for stimulating reepithelialisation during wound healing. More particularly, the present invention relates to a mineralocorticoid receptor antagonist or an inhibitor of mineralocorticoid receptor gene expression for use in a method for stimulating reepithelialisation of the skin or of the cornea during wound healing..
Universite Paris Descartes


03/24/16
20160081959 

Method of using arginine silicate inositol complex for wound healing or repair


A method for treating a wound or injury in an individual is provided, comprising the steps of administering to the individual afflicted with the wound or injury a composition including an effective amount of arginine silicate inositol (asi), optionally in combination with another component, and a nutraceutically or pharmaceutically acceptable carrier.. .
Glanbia Plc


03/24/16
20160081858 

Compositions and methods for the prevention of scarring and/or promotion of wound healing


The present disclosure provides methods of preventing and/or reducing scar contracture and methods of promoting wound healing by utilizing an electrospun biocompatible scaffold.. .
Duke University


03/24/16
20160081580 

Arrangement for facilitating wound healing, a measuring wound healing and a wound dressing


The present invention relates to the field of electrotherapy and measuring by means of electric currents for diagnostic purposes, and more particularly to an electrode arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing having an electrode arrangement. A wound dressing according is described which includes at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying lidc type electrical stimulation current to the wound area and for bioimpedance measurement.
Åbo Akadem


03/17/16
20160075764 

Optimal interstrand bridge for collagen mimics


Novel collagen-mimetic peptides are disclosed comprising the formula (xaa-yaa-gly)n, where the amino acid at one of the xaa positions is substituted with a homocysteine residue. Also disclosed are multi-stranded novel collagen-mimetic peptides comprising a first strand as described above that is covalently bonded with a disulfide bridge to a second strand comprising the formula (xaa-yaa-gly)m, where the amino acid at one of the yaa positions is substituted with a cysteine residue.
Wisconsin Alumni Research Foundation


03/17/16
20160074553 

Dressing for compromised wound healing


The invention relates to a bioactive medical product, or dressing, characterised in that it comprises at least an inner layer formed by a hydrogel and an outer layer formed by a biodegradable and bioabsorbable polyurethane, said inner layer being impregnated with an n-terminal peptide of 20 amino acids of pro-adrenomedullin and the outer layer being impregnated with nanoparticles of bemiparin encapsulated in a biodegradable copolymer or polymer. The active components can be dosed in a sequential and controlled manner with this composition.
Universidad De Alcala De Henares


03/17/16
20160074520 

Wound healing compositions comprising biocompatible cellulose hydrogel membranes and methods of use thereof


The present invention provides a wound healing composition comprising a biocompatible hydrogel membrane wherein the hydrogel membrane has one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The invention further provides methods of treating a wound in a subject in need thereof, comprising contacting the wound with a biocompatible cellulose hydrogel membrane of the invention..
The Johns Hopkins University


03/17/16
20160074466 

Angiotensins for treatment of fibrosis


The present invention provides, among other things, methods and compositions for treating or preventing fibrotic diseases, disorders or conditions based on angiotensin (1-7) polypeptides, and analogs or derivatives thereof. In some embodiments, compositions and methods for treating or preventing pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease (copd), asthma, cystic fibrosis, kidney fibrosis, liver fibrosis, systemic sclerosis, post-surgical adhesions, accelerating wound healing, and reducing or preventing scar formation are provided..
Tarix Pharmaceuticals Ltd.


03/17/16
20160074373 

Methods and compositions for inhibiting human copper trafficking proteins atox1 and ccs


Compositions and methods concern organic molecules that bind to human atox1 and ccs at the copper trafficking interface of these proteins. This binding suppresses copper trafficking, which leads to inhibition of cancer cell proliferation and tumor growth.
Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences


03/17/16
20160074325 

Low-dimensional structures of organic and/or inorganic substances and use thereof


The object of the present invention is low-dimensional, primarily 2d folded structures of organic and/or inorganic substances and/or their agglomerates, which have folds and faces of irregular shape and exhibit high local electric field strength generated by surface charges on the said folds, faces and edges, and use thereof: as sorbents of organic particles (molecules, bacteria, viruses, proteins, antigens, endotoxins) and inorganic particles (metal ions, colloids); as an agent with wound healing and antibacterial activity; as an agent for tumor cell growth inhibition.. .
National Research Tomsk Polytechnic University (tpu)


03/10/16
20160068499 

Methods and compositions for wound healing


The present invention relates to epoxy-tigliane compounds and their use in promoting wound healing. In particular embodiments, the epoxy-tigliane compounds are epoxy-tigliaen-3-one compounds.
Qbiotics Limited


03/10/16
20160067520 

Photodynamic therapy


There is herein described apparatus and a method for performing photodynamic therapy (pdt) and apparatus for performing pdt. More particularly, there is herein described a method of using pdt and associated apparatus over a prolonged period for the treatment of a range of therapies such as wound healing, cancer treatment (including both skin and internal body cancer) and psoriasis..
Ambicare Health Limited


03/10/16
20160067286 

Formulation for accelerating wound healing, preparation method and administering the same


Disclosed is a formulation for accelerating wound healing, preparation method and administering method of the same. A formulation for accelerating wound healing comprises cell culture medium which is obtained by culturing transfected endothelial progenitor cells which are acquired by transfecting microrna let-7g into endothelial progenitor cells.

02/25/16
20160051726 

Collagenous foam materials


Provided is a foam material, comprising a plurality of substantially collagenous beads, wherein the foam material is a bead foam, and wherein adjacent collagenous beads are fused together by a network of collagen fibres. Also provided are methods for preparation of foam materials comprising a plurality of substantially collagenous beads.
Queen's University At Kingston


02/25/16
20160051724 

Polymer based hydrogel


The present invention relates to an anti-aging antimicrobial wound healing polymer based hydrogel. In the study of the present invention, a wound healing gel formulation is developed by combining poloxamer polymers and boron component at adequate concentrations in a carbopol based gel.
Yeditepe Universitesi


02/25/16
20160051722 

Mesenchymal stem cell-hydrogel-biodegradable or mesenchymal stem cell-hydrogel-undegradable support composition for skin regeneration or wound healing


The present invention relates to a composition comprising mesenchymal stem cell-hydrogel-biodegradable support or mesenchymal stem cell-hydrogel-undegradable support, a sheet comprising the composition and a method for the preparation thereof. By using the sheet comprising the adipose-derived mesenchymal stem cell-hydrogel biodegradable or undegradable support, stem cells of high activity may be applied directly to the wound without isolation process using protease.
Anterogen Co., Ltd.


02/18/16
20160045460 

Highly protonated hydronium and carbamide as a skin sanitizing and wound healing solution


A water-based, alcohol-free, skin sanitizing and wound healing solution with a natural skin softener, where the nature of the biocidal enhancer used in the process of making the solution significantly increases efficacy while simultaneously enabling much more economical manufacturing, processing and transportation of the product. As the present solution is water-based, no further moisturizing additives are required, and those with sensitive skin, diabetes, allergies or religious beliefs are able to use the product without concern..

02/11/16
20160039892 

Artificial transcription factors and their use for the treatment of maladapted wound healing in the eye


The invention relates to artificial transcription factors comprising polydactyl zinc finger proteins targeting promoters of genes involved in maladapted wound healing in the eye. Such artificial transcription factors are useful for the treatment of fibrocontractive retinal disorders, such asepiretinal gliosis, proliferative vitreoretinopathy, proliferative diabetic retinopathy and epiretinal membrane, and for the treatment of fibroplasia associated with glaucoma surgery..
Aliophtha Ag


02/11/16
20160038632 

Adaptive drug delivery from an artificial polymer skin with tunable properties for tissue engineering


The present invention provides, among other things, a composite device comprised of a porous polymer membrane carrying active growth factors. Composite devices are characterized by an ability to controllably degrade for repair of bone and/or tissue defects sustained from traumatic wounds or congenital defects through eluting growth factor over readily adapted time scales inducing a natural wound healing cascade and rapid bone repair.
Massachusetts Instutite Of Technology


02/11/16
20160038442 

Materials and methods for controlling infections with negative pressure wound therapy


The subject invention provides a method for promoting wound healing and preventing an infection or treating an existing infection with negative pressure wound therapy, said method comprising the steps of providing a sterile disinfectant composition comprising an active agent comprising chlorhexidine and administering the sterile disinfectant composition to the wound site prior to, during and/or following negative pressure wound therapy. The subject invention also provides a kit comprising the sterile disinfectant composition and, optionally, devices for administration of the sterile disinfection composition to the site with negative pressure wound therapy..
Innovation Technologies, Inc.


02/04/16
20160030624 

Methods and compositions for wound healing


The present invention relates to methods and compositions for wound healing. In particular, the present invention relates to promoting and enhancing wound healing by utilizing cross-linker covalent modification molecules to attach and deliver wound active agents to a wound.
Imbed Biosciences, Inc.


02/04/16
20160030564 

Biophotonic materials and uses thereof


The present disclosure provides topical biophotonic materials and methods useful in phototherapy. In particular, the topical biophotonic materials of the present disclosure include a cohesive matrix, and at least chromophore which can absorb and emit light from within the topical biphotonic material, wherein the topical biophotonic material is elastic.
Klox Technologies Inc.


02/04/16
20160030525 

Erythropoietin and fibronectin compositions for therapeutic and cosmetic applications


A method of promoting wound healing or connective tissue reconstruction and a method of treating ischemia in a subject in need thereof are disclosed. The methods comprising topically administering to the subject about 10-30 mg per cm2 wound tissue of erythropoietin and about 100-300 mg per cm2 wound tissue of fibronectin, thereby promoting wound healing or connective tissue reconstruction or treating ischemia in the subject.
Remedor Biomed Ltd.


02/04/16
20160030496 

Therapeutic viral microparticles for promoting stent biofunctionality and wound healing in vertebrate individuals


The present disclosure provides viral microparticles comprising genetically-engineered baculoviruses (at least partially) embedded in a polymeric matrix for the local delivery of therapeutic nucleic acid molecules to the cells of a vertebrate individual (optionally in combination with a medical implant such as vascular stent platform). The viral microparticles are especially useful for promoting the healing of a wound as well as the repair of a blood vessel and prevent pathological scarring.
Mangogen Pharma Inc.


02/04/16
20160030476 

Compositions, methods and devices for promoting wound healing and reducing infection


Compositions, methods and devices are provided for promoting healing and preventing and treating infection in mammalian subjects. The compositions include pharmacologically active, protease inhibiting, cytokine protecting, aqueous media soluble sulfonated materials, optionally associated with one or more secondary therapeutic agents or carriers, to reduce one or more of inflammation, bacterial proliferation and proteolytic activity.
Iasis Molecular Sciences


01/28/16
20160023997 

Absorbable polyurethanes and methods of use thereof


Disclosed are novel bioabsorbable and biodegradable monomer compounds, bioabsorbable and biodegradable polymers therefrom, and methods of making such monomers and polymers, which are useful in pharmaceutical delivery systems, tissue engineering applications, tissue adhesives products, implantable medical devices, foams and reticulated foams for wound healing and drug delivery, bone hemostats and bone void fillers, adhesion prevention barriers, meshes, filters, stents, medical device coatings, pharmaceutical drug formulations, consumer product and cosmetic and pharmaceutical packaging, apparel, infusion devices, blood collection tubes and devices, other medical tubes, skin care products, and transdermal drug delivery materials.. .
Bezwada Biomedical, Llc


01/28/16
20160022773 

Methods for promoting wound healing and hair growth


The present invention generally relates to uses of glial cell line-derived growth factor (gdnf) in cutaneous wound healing and hair growth. Methods of effecting hair growth and/or wound healing which feature administration of gdnf, or a biologically active fragment thereof, to subjects, e.g., human subject, are disclosed herein.
The Jackson Laboratory


01/28/16
20160022759 

Methods for increasing the selective efficacy of gene therapy using car peptide and heparan-sulfate mediated macropinocytosis


Disclosed are compositions and methods for triggering disease selective macropinocytosis. The compositions can serve as a marker of disease activity and as a trigger of enhanced macropinocytosis in tissues undergoing disease remodeling such as wound healing, cancer, pah, inflammation, diabetes, crohn's disease, ulcerative colitis, ankylosing spondylitis, diseases of the endometrium, psoriasis, irritable bowel syndrome, arthritis, fibrotic disorders, interstitial cystitis, autoimmune diseases, asthma, acute lung injury, and adult respiratory distress syndrome.
Vascular Biosciences


01/28/16
20160022735 

Methods and compositions for promoting wound healing


The present invention provides methods and compositions that use the combination of tris and edta to inhibit the growth of microorganisms at the site of a wound or burn, and/or to promote the healing of a wound or burn, and/or to reduce the sensation of pain at the site of a wound or burn. The amount of tris and edta applied to a wound or burn can be selected to achieve one or more of the foregoing effects..
The University Of Georgia Research Foundation, Inc.


01/28/16
20160022730 

Compositions and methods of use for wound healing


Described herein are a solution, composition, and kit of poly (acetyl, arginyl) glucosamine (paag), methods of making the solution, and method of treating wounds with the solution, the method comprising administering to a subject an effective amount of a solution comprising paag, wherein the paag when administered topically contacts the wound, thereby treating the wound.. .
Synedgen Inc.


01/21/16
20160015962 

Smart patch for wound management


A flexible patch is provided that is capable of emitting light in the uv, visible, and/or infrared electromagnetic spectrums. The patch contains a feedback process and system using one or more sensors and a controller on the patch to (1) accelerate the wound healing process by providing adaptable, controlled light exposure and electrical stimulation, (2) monitor the healing process for signs of infection (3) eliminate bacterial infections by sanitizing the infected site and (4) relaying the information wirelessly to a central location for storage and interpretation by a physician as well as by providing the ability to receive feedback and operating instructions from the physician from a remote location..

01/21/16
20160015791 

Use of angiogenin or angiogenin agonists for treating diseases and disorders


The invention provides a method of treating a disorder characterised by elevated or dysregulated myostatin, disorders where the interaction between follistatin and angiogenin can be used to improve function in tissues, neurological diseases or disorders, spinal injuries or diseases, bone diseases or disorders, diseases involving glucose homeostasis, wound healing, neuroprotection, nervous system functional support or managing metabolic diseases, the method comprising administering an effective amount of angiogenin or an angiogenin agonist. Compositions and neutraceuticals comprising angiogenin are also provided..
Murray Goulburn Co-operative Co., Limited


01/21/16
20160015592 

Micromechanical force devices for wound healing acceleration


An apparatus provides micromechanical forces on a wound bed to accelerate healing of a wound. The apparatus includes a pressure chamber having a substantially airtight plunger and an inlet fluidly connected to a first end of a conduit.
The Brigham And Women's Hospital


12/31/15
20150376623 

Antisense oligonucleotides directed against connective tissue growth factor and uses thereof


This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.. .
Isis Pharmaceuticals, Inc.


12/31/15
20150376599 

Non-contact accelerating wound healing


An apparatus and method for accelerating the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells. The apparatus and method of the present invention accelerates the healing of wounds by electrotaxis of cells.
Ohio State Innovation Foundation


12/31/15
20150374720 

Methods and products for increasing the rate of healing of tissue wounds


Disclosed are methods for increasing the rate of healing of a tissue wound by administering a composition including a therapeutically effective amount of at least one cationic steroid antimicrobial (csa). Also disclosed herein are methods of promoting wound healing in a subject in need of such promotion, comprising administering a composition comprising a therapeutically effective amount of at least one csa.
Brigham Young University


12/31/15
20150374641 

Film-forming pharmaceutical composition for wound healing and preparing the same


The present invention relates to a pharmaceutical composition for forming a film directly on a wound to accelerate wound healing, a use for the same, a treatment method using the same, and a method for preparing the same. The film-forming composition according to the present invention forms a film directly on the wound to increase the adhesion to the wound.
Dong-a Pharmaceutical Co., Ltd


12/24/15
20150367024 

Nanofibrillar polysaccharide for use in the control and prevention of contraction and scarring


The present invention relates to nanofibrillar polysaccharide hydrogels for use in the prevention and control of scarring and contraction in connection with wound healing or tissue repair.. .
Upm-kymmene Corporation


12/17/15
20150361176 

Ligands that bind tgf-beta receptor ii


The disclosure provides an anti-tgfbetarii immunoglobulin single variable domain. Suitably, an anti-tgfbetarii immunoglobulin single variable domain in accordance with the disclosure is one having an amino acid sequence as set forth in any one of seq id no:1-28 having up to 5 amino acid substitutions, deletions or additions.
Glaxo Group Limited


12/17/15
20150359842 

Pro-angiogenic fragments of prominin-1 and uses thereof


Described have herein are peptide analogs of a prominin-1 peptide, drvqrqtttvva (seq. Id.
Children's Medical Center Corporation


12/17/15
20150359764 

Methods of treatment using 3-bromopyruvate and other selective inhibitors of atp production


The present invention provides methods for preventing or treating infections, especially bacterial infections, by administering selective inhibitors of atp production to inhibit glycolytic enzymes, such as glyceraldehyde 3-phosphate dehydrogenase (gapdh). As such, the present invention further provides methods for preventing or treating inflammation and sepsis associated with infections, as well as increased wound healing and decreased wound scarring..
Prescience Labs, Llc


12/10/15
20150353605 

Short bio-active peptides for promoting wound healing


Peptides having four to six amino acid residues are disclosed that possess biological activity. These peptides constitute short fragments of the peptide hb-107 (mpkekvflkiekmgrnirn), which itself is a fragment of the antimicrobial protein cecropin b, and exhibit cell stimulatory and migratory properties.
Helix Biomedix, Inc.


12/10/15
20150352183 

Laminins, derivatives, and compositions including same and methods for their therapeutic use


In various embodiments, the present disclosure provides a method of treating a subject using laminin or a composition that includes laminin. In one embodiment, the method is used to enhance muscle regeneration, maintenance, or repair in a subject.
Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada


12/10/15
20150352152 

Fluid associated with adult stem cells for medical, cosmetic, and veterinary use


Apparatus and process to create, expand, and localize the population of stem cells in adult tissues by placing a foreign body either in omentum or in the subcutaneous tissue. The apparatus 1) traps the granulation fluid, cells a fluid rich in a myriad of growth factors, 2) mobilizes and concentrates free-floating stem cells in the granulation fluid and 3) stimulates the growth of a new tissue around the apparatus, which provides another source of stem cells.

12/10/15
20150352151 

Activated leukocyte composition and uses for wound healing


Disclosed are therapeutic, blood-derived activated leukocyte compositions, methods of making them, and methods of using the compositions to repair or promote the prevention and healing of wounds.. .
Macrocure Ltd.


12/03/15
20150346216 

Devices and methods for the diagnosis and treatment of wounds using biomarkers


The present invention provides for devices and methods for determining the healing phase of a wound. In some aspects, the present invention provides a wound diagnosis device comprising a surface and at least one agent that is specific to a desired biomarker.
Kci Licensing, Inc.


12/03/15
20150342966 

Na/k-atpase ligand and uses thereof in wound healing


Methods and compositions for detecting, treating, characterizing, and diagnosing interstitial lung and/or fibrotic diseases are described.. .
The University Of Toledo


12/03/15
20150342179 

Compositions for internal and external use as an insecticide, ovicide, repellent and for wound healing


Exemplary embodiments of the present invention relate to pesticides, insecticides, insect repellant, insect anti-feeding, cleaning, glue dissolving and anti-irritation and wound healing compositions for humans and animals and, more particularly, to such compositions which are effective in killing, removing and/or repelling a wide range of endoparasites, ectoparasites and insects while also being non-toxic to humans, animals, and the environment. An exemplary embodiment of the present invention is directed to an aqueous composition including a mixture of at least one ethanolamide and at least one esterified fatty acid.
Natureza, Inc.




Wound Healing topics: Wound Healing, Amino Acid, Amino Acid Sequence, Proliferation, Theophylline, Inflammation, Antimicrobial, Epithelial, Amino Acids, Skin Graft, Bone Healing, Vascular Disease, Skin Ulcer, Bacterial Infection, Dysfunction

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