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Wound Healing patents

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This page is updated frequently with new Wound Healing-related patent applications.




 Improved wound healing compositions and treatments patent thumbnailImproved wound healing compositions and treatments
This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase..
Coda Therapeutics, Inc.


 Collagen and micronized placental tissue compositions and methods of making and using the same patent thumbnailCollagen and micronized placental tissue compositions and methods of making and using the same
Described herein are compositions of collagen and micronized placental tissue components, methods for producing the same and methods for using the same for wound healing, repairing damaged tendons, cosmetic applications and covering biocompatible materials and/or devices.. .
Mimedx Group, Inc.


 Collagen compositions and uses for biomaterial implants patent thumbnailCollagen compositions and uses for biomaterial implants
Compositions containing purified collagen biomaterial derived from tissues, for example, insoluble amnion, soluble amnion, soluble chorion of the human placenta, are provided. The collagen compositions can be used to promote wound healing, promote tissue regeneration, prevent or reduce scarring, reduce local inflammation, minimize tissue rejection, promote graft integration.
Mam Holdings Of West Florida, L.l.c.


 Combination treatments and compositions for wound healing patent thumbnailCombination treatments and compositions for wound healing
Viral vegf and viral anti-inflammatory cytokine compositions, methods of treatment using them, and kits containing them for use in the promotion and/or improvement of wound healing and/or tissue repair, and for anti-scarring, anti-inflammatory, anti-fibrosis and anti-adhesion indications.. .
Otago Innovation Limited


 Dissection handpiece and  reducing the appearance of cellulite patent thumbnailDissection handpiece and reducing the appearance of cellulite
A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece.
Ulthera, Inc.


 Three-dimensional porous film contact layer with improved wound healing patent thumbnailThree-dimensional porous film contact layer with improved wound healing
A wound dressing has a micro-architecture to produce appropriate strains in cells to promote the healing a wound. The apparatus includes a wound cover for defining a reservoir over a wound in which a negative pressure may be maintained by forming a substantially fluid-tight seal around the wound, a vacuum source in fluid communication with the reservoir and suitable for providing an appropriate negative pressure to the reservoir to stimulate healing of the wound, and a porous structure positioned in contact with the wound for delivering micro-mechanical forces to localized areas of the wound.
Smith & Nephew, Inc.


 Modified nucleic acids, and acute care uses thereof patent thumbnailModified nucleic acids, and acute care uses thereof
The invention provides compositions and methods for effecting wound healing in a mammal, where the compositions include therapeutic mrna which incorporate modified nucleosides and nucleotides.. .
Moderna Therapeutics, Inc.


 Composite bioabsorbable barrier membranes with sustained dual drug delivery for tissue engineering and guided tissue regeneration patent thumbnailComposite bioabsorbable barrier membranes with sustained dual drug delivery for tissue engineering and guided tissue regeneration
In this invention, composite polymeric barrier membrane is developed for clinical applications related to guided tissue regeneration and guided bone regeneration. The compositions of this polymeric membrane have conventional mechanical functions of a barrier membrane and will enable space maintenance and stabilization of the healing surgical wound.

 Method for enhancing wound healing patent thumbnailMethod for enhancing wound healing
The invention relates to a method for enhancing wound healing in a subject in need thereof, comprising administering to the subject a composition comprising fibronectin type iii domain-containing protein 5 (fndc5) or its cleaved fragment irisin in an amount effective to enhance wound healing. .
National Sun Yat-sen University


 Methods of treating chronic wounds with amniotic fluid having elevated levels of tissue inhibitors of matrix metalloproteinases patent thumbnailMethods of treating chronic wounds with amniotic fluid having elevated levels of tissue inhibitors of matrix metalloproteinases
Methods for treating chronic wounds with an amniotic fluid having a therapeutically effective amount of tissue inhibitors of matrix metalloproteinases (timps) are described. The amniotic fluid can be obtained from a female donor during a period of gestation when the concentration of endogenous timps are at or near their maximum level.
Liventa Bioscience, Inc.


Methods and compositions for treatment of penile defects


A composition for use in treating penile defects, including erectile dysfunction and peyronie's disease, is provided. The composition includes adipose tissue and stem cells.

Pharmaceutical composition for improving wound healing or prophylactically preventing or inhibiting scar formation


A pharmaceutical composition for improving wound healing is provided. The pharmaceutical composition includes (a) hyaluronic acid or its derivation, (b) an effective amount of an active ingredient; and optionally (c) pharmaceutically acceptable carriers and/or excipients.
Yung Shin Pharm. Ind. Co., Ltd.


Therapeutic composition for wound healing


A therapeutic composition comprising a beta-glucan, at east one fatty acid, and at least one secondary polysaccharide, which may increase a rate of wound healing. A method for healing a wound in a subject, by administering to a subject in need thereof, the therapeutic composition as described..

Modulation of mrtf-a activity in pathologic fibrosis and wound healing


The present disclosure concerns uses for isoxazole compounds or salts or analogs thereof for the treatment of wounds. The present disclosure also concerns devices for delivering a isoxazole compound or salts or an analogs thereof to a wound site..
The Board Of Regents Of The University Of Texas Sy Stem


Variable intensity laser treatments of the skin


A method for providing localized heating of the dermal layers of skin of a patient, using energy in the form of a group of pulses having defined parameters in a controlled manner. This method preferably uses an optical delivery system to deliver pulsed energy to a specific spot of skin so that targeted layers of the affected skin are heated to a desired temperature range.
Seminex Corporation


Light activated composite tissue adhesives


A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions. These composites have also been found to be strong tissue adhesives that are effective in closing and sealing wounds, fixation of grafts/ implants and anastomoses.
Conversion Energy Enterprises, Inc.


Skin button used for wound healing


A skin button used for wound healing is provided, which includes a one-piece formed structure with upper layer and lower layer consisting of a 1st skin button and a 2nd skin button. A through hole is provided in a junction of the 1st skin button and the 2nd skin button, which runs through the 1st skin button and the 2nd skin button, so as to form a duct connected the 1st skin button and the 2nd skin button to an outside.
Shanghai Shili International Trading Co., Ltd.


Compositions and treatments based on cadherin modulation


Anti-cadherin and anti-zo-1 agents and compositions, and kits containing them for use in the promotion and/or improvement of wound healing and/or tissue repair, and for anti-scarring, anti-inflammatory, anti-fibrosis and anti-adhesion indications.. .
Coda Therapeutics, Inc.


Integrated zwitterionic conjugated polymers for bioelectronics, biosensing, regenerative medicine, and energy applications


The present invention is directed to a versatile and high performance zwitterionic cp platform, which integrates all desired functions into one material. This zwitterionic cp consists of the conducting backbone and multifunctional zwitterionic side chains.
The University Of Akron


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Antimicrobial silver hydrogel composition for the treatment of burns and wounds


An antimicrobial therapeutic hydrogel composition comprises a pharmaceutical and/or medical grade silver salt, and an aloe vera gel or extract. The composition could also include stabilizing agents, a non-ionic surfactant, polyol, and hydrophilic hygroscopic polymers.
Celacare Technologies, Llc


Methods and compositions to inhibit metastasis and to treat fibrosis and to enhance wound healing


Methods and compositions are provided for inhibiting or treating metastasis based on discoveries regarding kif19 and cep192. Methods and compositions are provided for enhancing wound healing, treating fibrosis, reducing scarring and treating nerve pain..
Albert Einstein College Of Medicine, Inc.


Light-emitting devices for wound healing


Methods and devices related to wound healing using phototherapy are described. Some embodiments provide an organic light-emitting diode device, such as a light-emitting device for phototherapy, comprising ring system 1, ring system 2, ring system 3, ring system 4 or ring system 5..
Nitto Denko Corporation


Wound cleansing apparatus


An apparatus for cleansing and promoting tissue growth in wounds, in which irrigant fluid optionally containing cell nutrients and/or other physiologically active material from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing, a biodegradable scaffold in contact with the wound bed and a means for fluid cleansing and back to the dressing. The apparatus has means for supplying thermal energy to the fluid in the wound.
Smith & Nephew Plc


Silk/platelet composition and use thereof


The present disclosure relates generally to silk fibroin and unlysed platelet compositions. The compositions are useful for a variety of medical uses such as wound healing or repair and soft tissue repair or augmentation..
Tufts University


Cosmetic and topical compositions comprising cannabigerol


This invention discloses various cosmetics and topical formulations comprising cannabigerol, a non-psychoactive cannabinoid. The formulation may be an anti-aging cream for day or night application, a hand and nail cream, an eye cream, an acne treatment cream or tonic, an anti-diaper rash cream, a shampoo, a conditioner, a body wash, a face wash, deodorant spray, or a lip balm formulation.
Axim Biotechnologies, Inc.


Substituted dihydropyrazolones for treating cardiovascular and hematological diseases


The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.. .
Bayer Intellectual Property Gmbh


Wound healing promoting granulation and epithelialisation at a tissue site


An apparatus for promoting granulation and epithelialisation at a tissue site having a substantially gas impermeable, flexible mat. A plurality of projections extend from a surface of the substantially gas impermeable, flexible mat, and each projection has a first end connected to the surface and a second end opposing the first end.
Kci Licensing, Inc.


Wound healing compositions involving medicinal honey, mineral ions, and methylglyoxal, and methods of use


The invention provides compositions based on either medicinal honey containing broad spectrum antibacterial activities of peroxide, polyphenols and methylglyoxal, or an effective amount of an active anti-inflammatory ingredient of mineral solids fortified with methylglyoxal antibacterial activity, or a mixture of both for the treatment of wounds; and methods of treating a wound, comprising contacting a wound with any one of the above compositions or a wound dressing containing any one of the above compositions.. .

Silver-copper-zinc oxide wound care system


A wound care system for promoting wound healing and for preventing infections thereof and a method for producing the same includes an anti-microbial solution and a multi-layer wound dressing. The anti-microbial solution contains a mixture of colloidal silver, colloidal copper and colloidal zinc oxide mixed in sterile purified water.

Compositions comprising sulfated polysaccharides and uses thereof


The present invention relates to a composition for intravaginal and/or for internal mucosal application, comprising an effective amount of a sulfated polysaccharide, one or more of a natural quaternary polymer, a quaternary molecular compound, a metalloproteinase inhibitor, one or more anti-inflammatory agent, an acid ph control buffering system or any combination thereof, and a pharmaceutically acceptable carrier. The invention is further related to a method of treating or alleviating vaginal infection, vaginal dryness, vaginal or vulvo vaginal atrophy, vaginal itching, dyspareunia, vaginal or vulvar pain, vaginal or perivaginal inflammation or for promoting vaginal or wound healing, vaginal atrophy/dryness caused by radiotherapy, chemotherapy and/or hormonal treatment and decreased vaginal boundary lubrication or a disease or condition associated therewith or of improving vaginal boundary lubrication.
Algamed Therapeutics (a.m.t) Ltd


Induction of cellular senescence for tissue therapies


Provided are compositions and methods for aiding in healing of a tissue wound in an individual. The method generally entail delivering to an individual in need thereof senescent cells such that healing of the wound is accelerated.
Health Research, Inc.


Wound care bandage and wound healing


A wound healing system and a wound care bandage are provided. The wound care bandage has an electronics housing that houses a battery and wound care microcontroller.
Enermed, Llc


Mir-92 inhibitors and uses thereof


The present invention provides oligonucleotide inhibitors of mir-92 and methods of using said inhibitors for inhibiting the function and/or activity of mir-92 in a subject in need thereof. The present invention also provides methods for evaluating or monitoring the efficacy of a therapeutic for promoting wound healing and selecting a subject for treatment with a therapeutic that modulates mir-92 function and/or activity..
Miragen Therapeutics, Inc.


Self adhering suction port pad securement device for use with a negative pressure wound healing drape or dressing


A securement device may have a release strip, a release layer, a film having an adhesive and/or a back layer. The release strip and/or the release layer may be removable from the adhesive.
George Medical, Llc


Cross-linked platelet material


This document provides methods and materials involved in making and using cross-linked platelet material (e.g., cross-linked lysate material from human platelets such as human platelets obtained from platelet blood collection preparations or platelet apheresis preparations). For example, methods and materials for cross-linking platelet material (e.g., lysate material obtained from human platelets) to form a matrix (e.g.
Mayo Foundation For Medical Education And Research


Use of nucleic acids with reduced pressure therapy


Provided is a method of treating a wound site. Also provided is a system for treating a wound site.
Kci Licensing, Inc.


Purin derivatives for use in the treatment of fab-related diseases


The present invention relates to the finding that certain dpp-4 inhibitors are particularly suitable for wound healing preferably in diabetic patients.. .
Boehringer Ingelheim International Gmbh


Bioresorbable wound dressing


The present invention is directed to novel non-woven fabrics containing growth and differentiation factor proteins. Said fabrics are specifically designed to accelerate tissue regeneration and wound healing processes of mammalian tissues.
Carl Freudenberg Kg


Lipid nanoparticles for wound healing


The present invention refers to lipid nanoparticles comprising a growth factor and/or an antimicrobial peptide and to the method for their preparation. Moreover, it refers to pharmaceutical compositions comprising such lipid nanoparticles, and a pharmaceutical acceptable carrier.
Praxis Biopharma Research Institute


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Compounds and formulations for the treatment of wounds


The present invention relates to the treatment of wounds. More particularly, it relates to compounds according to formula (1) for use in methods of promoting wound healing, to formulations which incorporate these compounds and to a method of treating wounds using such compounds and formulations: wherein r1 and r2 may be the same or different and are selected from the group consisting of hydrogen (h) and a physiologically hydrolysable chemical group consisting of alkyl, alkyl carbonyl, alkenylcarbonyl arylcarbonyl, heteroarylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, alkylether, alkenylether, arylether, and heteroarylether groups wherein the alkyl group or moiety consists of unsubstituted or substituted, straight-chain or branched-chain and cyclic alkyl groups having 2-22 carbon atoms, wherein the alkenyl moiety consists of unsubstituted and substituted, straight-chain or branched-chain and cyclic alkenyl groups having 2-22 carbon atoms, wherein the aryl moiety consists of unsubstituted and substituted phenyl, and phenalkyl groups wherein the alkyl moiety contains 1-3 carbon atoms and the phenyl moiety is unsubstituted or substituted, and the heteroaryl moiety is an aromatic 5- or 6-membered heterocyclic ring containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen, and sulphur..
Nitto Denko Corporation


Ointment containing a hydrolyzed fibroin and manufacturing same


Embodiments of the present invention provide a topical agent that is a preparation containing hydrolyzed silk. The topical agent is applied to a wound site for use in wound healing, an thus, an object thereof being to have an effect of promoting wound healing and to satisfy practical application conditions with regard to an irritative property, stability, handling ease, and the like.
Kagoshima University


Composition having a. paniculata for wound healing and skin whitening, and method by using the same


The present invention provides a pharmaceutical composition for wound healing and/or skin whitening. The pharmaceutical composition comprises active ingredient of andrographis paniculata extract and/or andrographolide and a pharmaceutical acceptable carrier.
National Dong Hua University


Wound healing electrode set


The set for the electrical stimulation of a patient, comprises a backing, at least one electrically active zone and a wire connected to said electrically active zone for connection to a stimulator. Said backing has the shape of a bandage or of a plaster..

Novel peptide having ability to synthesize collagen and use thereof


Provided are a cosmetic composition and pharmaceutical composition for wound healing capable of efficiently performing collagen synthesis in skin, wherein the compositions contain, as an active ingredient, yigsr peptide having the amino acid sequence of seq id no: 1 or a peptide derivative having a palmitoyl group added to an n-terminal of the peptide.. .

Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids


The present invention relates to the fields of medicine, cell biology, molecular biology and genetics. In particular, the present invention provides methods to isolate and purify microvesicles from cell culture supernatants and biological fluids.

Methods and compositions for promoting wound healing


The present invention provides methods and compositions that use the combination of tris and edta to inhibit the growth of microorganisms at the site of a wound or burn, and/or to promote the healing of a wound or burn, and/or to reduce the sensation of pain at the site of a wound or burn. The amount of tris and edta applied to a wound or burn can be selected to achieve one or more of the foregoing effects..

Bioactive alkaloid compositions and their medical uses


The present invention relates to a novel alkaloid and novel bioactive alkaloid fractions derivable from ribes preferably selected among ribes rubrum and ribes nigrum; methods of manufacturing such bioactive ribes alkaloid fractions and their use for the inhibition of ikk-β, pde4 and/or pde5 and in addition their promoting effect on mitochondrial biogenesis and function; their therapeutic or non-therapeutic applications as nutritive or medicinal products in the management of conditions associated with impaired mitochondrial function or ikk-β, pde4 and/or pde5 activity, such as inflammation, neurodegeneration, dyslipidemia, type 2 diabetes mellitus, impaired wound healing, sarcopenia and other conditions associated with muscle dysfunction or tiredness and fatigue, or where optimization of muscular or cognitive function is desired; extracts, juices or concentrates of ribes comprising such alkaloids; compositions comprising such alkaloids, including pharmaceutical compositions, nutritive product such as functional foods and nutraceutical compositions, and cosmetic compositions and medical devices.. .

Method for wound infection prevention


A wound healing device and method that greatly reduces the risk of infection of an incision or wound by removing fluid from the subcutaneous layers of the skin. The wound healing device includes a first portion that is positioned external of, and on top of, the wound.

Apparatus for wound infection prevention


A wound healing device and method that greatly reduces the risk of infection of an incision or wound by removing fluid from the subcutaneous layers of the skin. The wound healing device includes a first portion that is positioned external of, and on top of, the wound.

Method and improved wound healing


A pad for electrically stimulated wound healing, including a pad configured to be placed on a wound, at least one anode disposed on the pad to contact the wound, and at least one cathode disposed on the pad to contact the wound, the at least one cathode being disposed separately from the at least on anode. The pad wherein the at least one anode and the at least one cathode in contact with the wound provide a flow of electrical current in an intended direction through the wound based on the separate locations of the at least one anode and the at least one cathode..

Combination therapy to promote wound healing


Methods for increasing and/or promoting wound healing, wound re-epithelialization and dermal regeneration of epithelial tissues and cutaneous wounds by administration to a subject of an extracellular matrix scaffold or scaffold for dermal regeneration (sdr) populated with beta adrenergic receptor antagonist pre-conditioned mesenchymal stem cells (mscs) are provided. Compositions and kits comprising an extracellular matrix scaffold (ecms) populated with beta adrenergic receptor antagonist pre-conditioned mesenchymal stem cells (mscs) are also provided..

Polymers and methods thereof for wound healing


Wherein y is 1 or more. Other embodiments of the invention provide a therapeutic method for treating a wound in an animal comprising administering to an animal in need of such therapy, an effective amount of a copolymer as described herein..

Method for wound infection prevention


A wound healing device and method that greatly reduces the risk of infection of an incision or wound by removing fluid from the subcutaneous layers of the skin. The wound healing device includes a first portion that is positioned external of, and on top of, the wound.

Pendant hydrophile bearing biodegradable compositions and related devices


A composition comprising at least one polymer having the structure a-b-a′, wherein a and a′ may be the same or different and each is a degradable polyester component and wherein b is the reaction product resulting from the reaction between a diol, having one or more pendant oligomeric or polymeric groups, and a and a′. Additionally, a bioresorbable patch comprising: (a) an adhesion barrier component comprising the composition in the form of a film; and (b) an adhesive component comprising (i) at least one synthetic adhesive polymer and/or (ii) at least one polysaccharide.
Dsm Ip Assets B.v.


Synthetic microfluidic systems for wound healing


A method of assaying wound healing can include: growing cells on the matrix in the first flow channel; introducing an agent that removes the matrix from the junction; introducing a matrix material into the second flow channel so as to form the second matrix in the second flow channel and junction; and detecting cellular migration into the junction onto the second matrix. The agent that removes the matrix can include a biomolecule or chemical agent.
Cfd Research Corporation


Formulations comprising antisense nucleotides to connexins


A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin protein together with a pharmaceutically acceptable carrier or vehicle is useful in site specific down regulation of connexin protein expression, particularly in reduction of neuronal cells death, wound healing, reduction of inflammation, decrease of scar formation and skin rejuvenation and thickening.. .
Coda Therapeutics, Inc.


Protein biomaterials and biocoacervates and methods of making and using thereof


The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention relates to protein biocoacervates and biomaterials that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, coated medical devices (e.g.
Gel-del Technologies, Inc.


A wound dressing


The present invention relates to an impregnated wound dressing having an outer membrane overlay layer and to a method of production thereof. In particular the dressing comprises a core layer that has been impregnated with a wound healing agent, such as honey, and an outer membrane overlay layer..
Manukamed Limited


Wound healing using topical systems and methods


The present invention generally relates to compositions and methods for topical or transdermal delivery and treatment of wounds and/or promoting wound healing. In some cases, the composition may include nitric oxide and/or peptides.
Transdermal Biotechnology, Inc.


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Laser assisted wound healing protocol and system


A method of treating gum disease while healing the wound in the periodontium using a soft tissue diode laser which generates a beam of light having a wavelength in the visible portion of the electromagnetic spectrum (400 nm-700 nm) at a laser power of 0.001 to 1.2 watts, used with intermittent stops to control tissue temperature and biostimulate the periodontium to regenerate and heal its wound when used with substrates, the method comprising: placing the tip of the laser inside the sulcus; penetrating the entire sulcus by moving the laser light circumferentially around the tooth vertically and horizontally throughout the sulcus with intermittent stops to control tissue temperature and placing substrates in the sulcus prior to blood clot formation; followed by rf treatment of the sulcus by placing the rf headpiece tips perpendicular to the sulcus to receive rf current which further penetrates the wound site.. .
Bioregentech


Negative pressure wound dressing


A negative pressure wound dressing is provided. The negative pressure wound dressing sequentially includes a backing layer, a water blocking layer, an absorbent layer and a wound contacting layer.
Benq Materials Corporation


Multimeric tie 2 agonists and uses thereof in stimulating angiogenesis


The present invention provides a multimeric form of a tie 2 binding peptide monomer, wherein the multimeric form has tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates angiogenesis and promotes wound healing.
Sunnybrook Health Sciences Centre


Amniotic membrane preparations and purified compositions and anti-inflammation methods


Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating tgf β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues.
Tissuetech, Inc.


Bone matrix compositions and methods


Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity.
Warsaw Orthopedic, Inc.


Tissue culture testing systems and methods of use


Embodiments of the present disclosure provide materials and methods relating to cell and tissue culture testing systems. Certain embodiments of the present disclosure relate to in vitro testing systems that are useful for performing experiments to investigate the potential for various factors to reduce bioburden, reduce the manifestations of infection, and to promote wound healing in cultured cells and tissues.
Barry University


Nitric oxide delivery system and methods of use


Embodiments of the present disclosure provide systems and devices for delivering gaseous nitrous oxide (gno) under therapeutic parameters to reduce infection in a subject. Certain embodiments include devices and systems for delivering pressurized gno to reduce bioburden and promote healing in the wounds of subjects having various disease conditions, including skin and soft tissue infections (sstis) and osteomyelitis.
Barry University


Biological film-forming agent for facilitation of wound healing and coating and protection of biological organs


The present invention relates to a biological film-forming agent which is for facilitating wound healing and coating and protecting biological organs, and for coating and protecting damaged cells, wound surfaces, organs and damaged sites of organs, and wound surfaces reaching soft tissues such as muscle and facia, periosteum or bone cortex. Provided is a biological film-forming agent for suppressing exudation of intracellular fluid from damaged cells, suppressing expansion of inflammation reactions and secondary inflammation reactions resulting from production of fibrin and eliminating adverse effects caused by formation of stabilised fibrin on healing.
Lilac Laboratory Co., Ltd.


Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment


Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating tgf β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues.
Tissuetech, Inc.


Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition


Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating tgf β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues.
Tissuetech, Inc.


Purified amniotic membrane compositions and methods of use


Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating tgf β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues.
Tissuetech, Inc.


Composition of mesenchymal stem cells


This invention relates in general to a mesenchymal stem cell (msc) therapy. This invention further relates to the isolation and applications of gingiva derived mesenchymal stem cells.
University Of Southern California


Drug eluting silicone gel sheeting for wound healing and scar reduction


Provided are methods of making devices that can be applied to the skin to promote healing of wounds and the reduction or prevention of scarring. The devices include compositions of various silicone compounds loaded with active pharmaceutical agents..
Allergan, Inc.


Devices and methods for closing tissue openings


A medical device to assist surgical procedures by ensuring a controlled incision and a fast and non-invasive wound closure. The device may comprise two sections, each of which comprises a plurality of plates for adhering the device to the skin.
Zhip Meditech, Inc.


Wound healing agent


The present invention aims to provide a wound healing agent that inhibits bacterial growth, promotes granulation tissue formation and epithelization, and minimizes foreign body reaction in the granulation tissue. The wound healing agent of the present invention contains protein (a) and water, wherein the protein (a) contains: gagags (1); and an amino acid sequence (x) and/or an amino acid sequence (x′), and the total percentage of β turns and random coils in the protein (a) as determined by circular dichroism spectroscopy is 60 to 85%, and the percentage of the total number of amino acid residues in the amino acid sequences (x) and (x′) is 50 to 70% of the total number of amino acid residues in the protein (a).

Wound healing and tissue engineering


The present invention is directed to wound healing scaffolds cografted with a population of stem cells, wherein the population of stem cells are abcb5+ stem cells. The scaffolds are, for instance, collagen glycosaminoglycan scaffolds..

Methods to inhibit infection during wound healing with topical compositions including amino acids


A method that inhibits infection during wound healing by topical application of a single composition, which contacts a wound for a period of time to initiate wound healing. The single composition may include a mixture of all or some of the amino acids including: histidine monohydrochloride monohydrate; isoleucine; leucine; lysine acetate; methionine; phenylalanine; threonine; tryptophan; valine; alanine; arginine acetate; aspartic acid; glutamine; glycine; proline; serine; and tyrosine, which may provide aqueous mixtures of a range of osmolarities or a powdered mixture of amino acids.

Wound healing via autologous stem cell mobilization


The present invention relates to the field of wound healing. More specifically, the present invention provides methods and compositions useful for improved wound healing via autologous stem cell mobilization.

Combination sis and vacuum bandage and method


A wound care bandage for treating a wound is provided. The bandage includes an sis layer to be placed on the wound surface and a cover to placed over the wound.

Crosslinked human or animal tissue products and their methods of manufacture and use


Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material.

An arrangement for facilitating wound healing, a measuring wound healing and a wound dressing


The present invention relates to the field of electrotherapy and measuring by means of electric currents for diagnostic purposes, and more particularly to an electrode arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing having an electrode arrangement. A wound dressing according to the present invention comprises at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying lidc type electrical stimulation current to the wound area and for bioimpedance measurement.

Promotion of wound healing


The present invention provides compositions and methods that promote wound healing in a subject with a cutaneous injury. In particular, the present invention provides systemic and/or local administration of one or more compositions that cause ganglioside depletion (e.g., glucosylceramide synthase (gcs) inhibitors) for the treatment of cutaneous wounds..
Northwestern University


Porous foams derived from extracellular matrix, porous foam ecm medical devices, and methods of use and making thereof


The invention disclosed herein is directed to a porous wound healing foam composition that is made from an extracellular matrix of a mammal, method of making, and method of using.. .
Acell, Inc.


Activated leukocyte conditioned supernatant and uses for wound healing


Disclosed are therapeutic, activated leukocyte conditioned supernatants, methods of making them, and methods of using the conditioned supernatants to repair or promote healing of wounds.. .
Macrocure Ltd.


Enzymatic process for the production of mannosylerythritol lipids from lignocellulosic materials


The present invention relates to processes for the production of microbial glycolipids, mannosylerythritol lipids (mel), from lignocellulosic carbon source. These processes are characterized in that the use of lignocellulosic materials for the production of a microbial glycolipids, mel, comprising a fermentation preferably using fungi of the genus pseudozyma or other microorganisms such as genetically modified fungi or bacteria.
LaboratÓrio Nacional De Energia E Geologia


Apparatus and methods for controlling tissue oxygenation for wound healing and promoting tissue viability


A wound treatment system includes a housing. A processor is located in the housing.
Electrochemical Oxygen Concepts, Inc.


Composition for use in wound healing in burns


The preset invention relates to a new method for wound healing, particularly in burns, comprising epinecidin-1 (epi-1) or pardaxin (ge33), optionally in the incorporation into collagen.. .
Academia Sinica


Methods and compositions for stimulating reepithelialisation during wound healing


The present invention relates to methods and compositions for stimulating reepithelialisation during wound healing. More particularly, the present invention relates to a mineralocorticoid receptor antagonist or an inhibitor of mineralocorticoid receptor gene expression for use in a method for stimulating reepithelialisation of the skin or of the cornea during wound healing..
Universite Paris Descartes


Method of using arginine silicate inositol complex for wound healing or repair


A method for treating a wound or injury in an individual is provided, comprising the steps of administering to the individual afflicted with the wound or injury a composition including an effective amount of arginine silicate inositol (asi), optionally in combination with another component, and a nutraceutically or pharmaceutically acceptable carrier.. .
Glanbia Plc


Compositions and methods for the prevention of scarring and/or promotion of wound healing


The present disclosure provides methods of preventing and/or reducing scar contracture and methods of promoting wound healing by utilizing an electrospun biocompatible scaffold.. .
Duke University


Arrangement for facilitating wound healing, a measuring wound healing and a wound dressing


The present invention relates to the field of electrotherapy and measuring by means of electric currents for diagnostic purposes, and more particularly to an electrode arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing having an electrode arrangement. A wound dressing according is described which includes at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying lidc type electrical stimulation current to the wound area and for bioimpedance measurement.
Åbo Akadem


Optimal interstrand bridge for collagen mimics


Novel collagen-mimetic peptides are disclosed comprising the formula (xaa-yaa-gly)n, where the amino acid at one of the xaa positions is substituted with a homocysteine residue. Also disclosed are multi-stranded novel collagen-mimetic peptides comprising a first strand as described above that is covalently bonded with a disulfide bridge to a second strand comprising the formula (xaa-yaa-gly)m, where the amino acid at one of the yaa positions is substituted with a cysteine residue.
Wisconsin Alumni Research Foundation


Dressing for compromised wound healing


The invention relates to a bioactive medical product, or dressing, characterised in that it comprises at least an inner layer formed by a hydrogel and an outer layer formed by a biodegradable and bioabsorbable polyurethane, said inner layer being impregnated with an n-terminal peptide of 20 amino acids of pro-adrenomedullin and the outer layer being impregnated with nanoparticles of bemiparin encapsulated in a biodegradable copolymer or polymer. The active components can be dosed in a sequential and controlled manner with this composition.
Universidad De Alcala De Henares


Wound healing compositions comprising biocompatible cellulose hydrogel membranes and methods of use thereof


The present invention provides a wound healing composition comprising a biocompatible hydrogel membrane wherein the hydrogel membrane has one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The invention further provides methods of treating a wound in a subject in need thereof, comprising contacting the wound with a biocompatible cellulose hydrogel membrane of the invention..
The Johns Hopkins University


Angiotensins for treatment of fibrosis


The present invention provides, among other things, methods and compositions for treating or preventing fibrotic diseases, disorders or conditions based on angiotensin (1-7) polypeptides, and analogs or derivatives thereof. In some embodiments, compositions and methods for treating or preventing pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease (copd), asthma, cystic fibrosis, kidney fibrosis, liver fibrosis, systemic sclerosis, post-surgical adhesions, accelerating wound healing, and reducing or preventing scar formation are provided..
Tarix Pharmaceuticals Ltd.


Methods and compositions for inhibiting human copper trafficking proteins atox1 and ccs


Compositions and methods concern organic molecules that bind to human atox1 and ccs at the copper trafficking interface of these proteins. This binding suppresses copper trafficking, which leads to inhibition of cancer cell proliferation and tumor growth.
Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences


Low-dimensional structures of organic and/or inorganic substances and use thereof


The object of the present invention is low-dimensional, primarily 2d folded structures of organic and/or inorganic substances and/or their agglomerates, which have folds and faces of irregular shape and exhibit high local electric field strength generated by surface charges on the said folds, faces and edges, and use thereof: as sorbents of organic particles (molecules, bacteria, viruses, proteins, antigens, endotoxins) and inorganic particles (metal ions, colloids); as an agent with wound healing and antibacterial activity; as an agent for tumor cell growth inhibition.. .
National Research Tomsk Polytechnic University (tpu)


Methods and compositions for wound healing


The present invention relates to epoxy-tigliane compounds and their use in promoting wound healing. In particular embodiments, the epoxy-tigliane compounds are epoxy-tigliaen-3-one compounds.
Qbiotics Limited


Photodynamic therapy


There is herein described apparatus and a method for performing photodynamic therapy (pdt) and apparatus for performing pdt. More particularly, there is herein described a method of using pdt and associated apparatus over a prolonged period for the treatment of a range of therapies such as wound healing, cancer treatment (including both skin and internal body cancer) and psoriasis..
Ambicare Health Limited


Formulation for accelerating wound healing, preparation method and administering the same


Disclosed is a formulation for accelerating wound healing, preparation method and administering method of the same. A formulation for accelerating wound healing comprises cell culture medium which is obtained by culturing transfected endothelial progenitor cells which are acquired by transfecting microrna let-7g into endothelial progenitor cells.

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Collagenous foam materials


Provided is a foam material, comprising a plurality of substantially collagenous beads, wherein the foam material is a bead foam, and wherein adjacent collagenous beads are fused together by a network of collagen fibres. Also provided are methods for preparation of foam materials comprising a plurality of substantially collagenous beads.
Queen's University At Kingston


Polymer based hydrogel


The present invention relates to an anti-aging antimicrobial wound healing polymer based hydrogel. In the study of the present invention, a wound healing gel formulation is developed by combining poloxamer polymers and boron component at adequate concentrations in a carbopol based gel.
Yeditepe Universitesi


Mesenchymal stem cell-hydrogel-biodegradable or mesenchymal stem cell-hydrogel-undegradable support composition for skin regeneration or wound healing


The present invention relates to a composition comprising mesenchymal stem cell-hydrogel-biodegradable support or mesenchymal stem cell-hydrogel-undegradable support, a sheet comprising the composition and a method for the preparation thereof. By using the sheet comprising the adipose-derived mesenchymal stem cell-hydrogel biodegradable or undegradable support, stem cells of high activity may be applied directly to the wound without isolation process using protease.
Anterogen Co., Ltd.




Wound Healing topics:
  • Wound Healing
  • Amino Acid
  • Amino Acid Sequence
  • Proliferation
  • Theophylline
  • Inflammation
  • Antimicrobial
  • Epithelial
  • Amino Acids
  • Skin Graft
  • Bone Healing
  • Vascular Disease
  • Skin Ulcer
  • Bacterial Infection
  • Dysfunction


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