|| List of recent Vectors-related patents
| Polypeptides having beta-xylosidase activity and polynucleotides encoding same|
Provided are isolated polypeptides having beta-xylosidase activity and polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
| Targeted promotion of original titles|
Techniques are described for promoting original media titles. Given metadata tags associated with the original title and other media titles, a tag data matrix is generated and factored into two matrices, one of which includes vectors representing the media titles in a first latent space.
| Scan chain configuration for test-per-clock based on circuit topology|
Aspects of the invention relate to generating scan chain configurations for test-per-clock based on circuit topology. With various implementations of the invention, weight vectors between scan chains in a circuit are first determined.
| Discovering and scoring relationships extracted from human generated lists|
A computer-implemented system and method for extracting human generated lists from an electronic database is described. The system searches for objects of the same class within a context window to identify human generated lists and stores them to an archive.
| System and method for automated market making|
Method and systems for design and operation of a prediction market. A plurality of security bundles and a plurality of payoff vectors may be defined, such that each payoff vector in the plurality of payoff vectors is associated with at least one outcome in a plurality of outcomes.
| Method and system for performing an opening auction of a derivative|
A method for determining execution states, market clearing prices and bid and ask prices for futures products at an opening auction. A plurality of orders is received, each order is associated with a price limit, a quantity, a participant and a futures product.
| Estimation and display for vector doppler imaging using plane wave transmissions|
Vector doppler imaging (vdi) improves on conventional color doppler imaging (cdi) by giving speed and direction of blood flow at each pixel of a display generated by a computing system. Multiple angles of plane wave transmissions (pwt) via an ultrasound transducer conveniently give projected doppler measurements over a wide field of view, providing enough angular diversity to identify velocity vectors in a short time window while capturing transitory flow dynamics.
| Systems and methods for vector stimulation in medical treatment|
Stimulation treatments for medical disorders comprise providing stimulation parameters that create partial stimulation signals which combine into vector signals. The individual partial signals may have frequency or temporal content that is unique rather than all being identical.
| Growth hormone polypeptides and methods of making and using same|
The present invention relates to compositions comprising growth hormone linked to extended recombinant polypeptide (xten), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of growth hormone-related diseases, disorders, and conditions.. .
| Trophectodermal cell-specific gene transfer methods|
The present inventors discovered that genes could be introduced specifically into trophectodermal cells with high efficiency, by infecting blastocysts with viral vectors carrying an arbitrary polynucleotide, or by using a nucleic acid transfection reagent in blastocysts, from which zona pellucida (extracellular matrix covering preimplantation early embryos to protect them from infection of viruses and the like) is removed. This method has no risk of infecting cells of the inner cell mass, which develops into a fetus in the future, with the introduced polynucleotide because the trophectoderm serves as a barrier.
| Compositions and methods for enhancing the pluripotency of stem cells|
Described herein is the finding that increasing the frequency of zscan4 activation in mouse es cells not only enhances, but also maintains their developmental potency in long-term cell culture. Particularly disclosed herein is the finding that the constitutive presence of zscan4-ert2, even in the absence of its usual activator tamoxifen, can increase the frequency of endogenous zscan4 activation in es cells, resulting in the increase of developmental potency of the es cells.
| Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences|
Provided is an isolated mammalian negative strand rna virus, metapneumovirus (mpv), within the sub-family pneumoviridae, of the family paramyxoviridae. Also provided are isolated mammalian negative strand rna viruses identifiable as phylogenetically corresponding or relating to the genus metapneumovirus and components thereof.
| Conjugates of gm-csf and il-7, compositions and methods related thereto|
In certain embodiments, this disclosure relates to conjugates comprising gm-csf and il-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the gm-csf and il-7 are connected by a polymer linker, e.g., polypeptide.
| System and method for live voice and voicemail detection|
A computer system for processing audio on a call having a processor in communication with non-volatile memory having code for converting recorded audio into a vector, comparing the recorded audio vector with a plurality of audio vectors and generating a comparative match number for each comparison, identifying a closest audio vector having a highest comparative match number above a predetermined threshold match number, connecting the call to an agent when the closest audio vector is designated as live-voice.. .
| Video decoding device, video decoding method, video decoding program, and video decoding integrated circuit|
With use of a simplified program or calculating device for motion compensation, a video decoding device decodes video data compressed by motion detection operations on macroblock units, as in the mpeg-4avc standard. The video decoding device splits compressed data blocks of the prescribed size, 16×16 pixels for instance, to generate sub-blocks, which are smaller than the blocks and on which the video decoding device is able to execute motion compensation operations.
| Real-time image processing method and device|
Disclosed herein are a method and a device of real-time image processing. The method comprises capturing three images, enhancing a resolution of the images to obtain for each image a high-resolution image (hri), obtaining two displacement vectors using the hris, obtaining a superimposed hri based on the hris and the displacement vectors, obtaining a compensatory vector based on the displacement vectors, and generating a super-resolution image based on the superimposed hri and the compensatory vector..
|Increasing soybean defense against pests|
Disclosed are pest resistance genes isolated from soybean. In several embodiments, a pest resistance gene isolated from soybean includes a nucleic acid sequence at least 80% identical to seq id no: 1 or seq id no: 2 or a degenerate variant thereof, or a fragment thereof.
|Item-based recommendation engine for recommending a highly-associated item|
Disclosed relates to a recommendation engine. The recommendation engine includes a query generation module configured to store a plurality of item vectors as a plurality of documents, configured to search for a reference document associated with the reference item among the plurality of the documents to extract a reference item vector and configured to generate a query including at least one user best associated with the extracted reference item vector if successful, each of the plurality of the item vectors corresponding to an element including a user-preference pair and a search module configured to calculate a correlation between the extracted reference item vector and each of the plurality of the item vectors in the plurality of the documents based on the generated query to provide the at least one recommendation item..
|Method for decomposing complex objects into simpler components|
Method for decomposing a complexly shaped object in a data set, such as a geobody (31) in a seismic data volume, into component objects more representative of the true connectivity state of the system represented by the data set. The geobody is decomposed using a basis set of eigenvectors (33) of a connectivity matrix (32) describing the state of connectivity between voxels in the geobody.
|Promoters, expression cassettes, vectors, kits, and methods for the treatment of achromatopsia and other diseases|
The present invention provides isolated promoters, transgene expression cassettes, vectors, kits, and methods for treatment of genetic diseases that affect the cone cells of the retina.. .
|Nucleotide cloning methods|
Methods of cloning insert sequences into cloning vectors with high efficiency and in the correct orientation are described. In one aspect, the invention features a method of producing a plasmid comprising an insert fragment and a vector fragment in a predetermined orientation.
|Sperm-specific cation channel, catsper2, and uses therefor|
Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (catsper2) are disclosed. The catsper2 protein is shown to be specifically expressed in sperm.
|Use of polypeptides having protease activity in animal feed and detergents|
The present invention relates to the use of isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides in animal feed and detergents. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides in e.g.
|Avian induced pluripotent stem cells and their use|
The present invention relates to the production of avian induced pluripotent stem cells from non-pluripotent somatic cells, including embryonic fibroblasts and adult somatic cells. In this method, avian (including quail or chicken) somatic cells are reprogrammed into a state closely resembling embryonic stem cells including the expression of key stem cell markers alkaline phosphatase, etc.
|Mycobacterial vaccine vectors and methods of using the same|
Mycobacterium bovis bcg is a potent stimulator of the cellular immune response and has potential as a recombinant vaccine vector. Disclosed are bcg strains that generate greater mhc class i presentation of a transgenic protein, relative to the unmutated parental strain, and that improve a recipient's cd8+ t cell response against the transgenic protein following vaccination.
|Method and apparatus for real-time conversion of 2-dimensional content to 3-dimensional content|
Various aspects of a method and apparatus for video processing may include a computing device communicably coupled to an external device. The computing device may be operable to determine an average vertical velocity and an average horizontal velocity of a subset of pixels in an image frame and determine a depth value for each pixel of the subset of pixels based on calculated motion vectors of the pixel of the subset of pixels, the average vertical velocity of the subset of pixels and the average horizontal velocity of the subset of pixels..
|Method and device for generating a motion field for a video sequence|
A method for generating a motion field between a current frame and a reference frame belonging to a video sequence from an input set of elementary motion fields is disclosed. The method comprises performed for each pixel belonging to said current frame: determining a plurality of candidate motion vectors between the current frame and the reference frame wherein each candidate motion vector is the result of the sum of a first motion vector between the current frame and an intermediary frame belonging to the video sequence and of a second motion vector between the intermediary frame and the reference frame; and selecting a motion vector among candidate motion vectors.
|System and method for exploiting scene graph information in construction of an encoded video sequence|
A system method and computer program product for creating a composited video frame sequence for an application. A current scene state for the application is compared to a previous scene state wherein each scene state includes a plurality of objects.
|Content adaptive prediction and entropy coding of motion vectors for next generation video|
Techniques related to content adaptive prediction and entropy coding of motion vectors are described.. .
|Coherence groups: region descriptors for low bit rate encoding|
The invention is directed to an efficient way for encoding and decoding video. Embodiments include identifying different coding units that share a similar characteristic.
|Method and systems of classifying a vehicle using motion vectors|
This disclosure provides methods and systems of classifying a vehicle using motion vectors associated with captured images including a vehicle. According to an exemplary method, a cluster of motion vectors representative of a vehicle within a target region is analyzed to determine geometric attributes of the cluster and/or measure a length of a detected vehicle, which provides a basis for classifying the detected vehicle..
|Method and device for compressing vertex data in three-dimensional image data|
A device for compressing vertex data in three-dimensional (3d) image data includes a codebook design module and a codeword search module. The codebook design module is configured for: grouping residual vectors of vertices in 3d image data for codebook design; generating, for each group of residual vectors, a sub-codebook formed by a specified number of codewords; and sending the generated sub-codebook corresponding to a group of residual vectors to the codeword search module.
|System and method for exploiting scene graph information in construction of an encoded video sequence|
A system method and computer program product for creating a composited video frame sequence for an application. A current scene graph state for the application is compared to a previous scene graph state wherein each scene graph state includes a plurality of hierarchical nodes that represent one or more objects at each node.
|Correction of crb1 mutations|
Genetically engineered mice having a corrected cbr1rd8 mutation and methods for correcting the cbr1rd8 mutation to produce the genetically engineered mice are provided according to aspects of the present invention. Kits, expression vectors and fusion proteins according to aspects of the invention are provided for use to produce the genetically engineered mice characterized by a corrected cbr1rd8 mutation..
|Anti-cyber attacks control vectors|
A method for calculating an effectiveness of anti-cyber attack controls, the method comprising using at least one hardware processor for: providing a matrix of attack method and technology layer pairs; providing anti-attack effectiveness values for a plurality of controls against the attack method and technology layer pairs; composing control groups each comprising multiple ones of said plurality of controls having the highest anti-attack effectiveness values; deriving control vectors from said control groups, said deriving being based on a regression analysis of all possible orders of controls in each one of said control groups; and displaying an effectiveness measure of at least some of the plurality of controls, based on the control vectors.. .
|Method, device and system for energy management|
The present application relates to carrying out energy management based on context information. In the method, apparatus and system according to the application, a context vector (820) is used to select a operational state plurality of operational state vectors (825, 835).
|Systems and methods for content response prediction|
Techniques for predicting a user response to content are described. According to various embodiments, a configuration file is accessed, where the configuration file includes a user-specification of raw data accessible via external data sources and raw data encoding rules.
|Evaluation predicting device, evaluation predicting method, and program|
Disclosed herein is an evaluation predicting device including: an estimating section configured to define a plurality of first latent vectors, a plurality of second latent vectors, evaluation values, a plurality of first feature vectors, a plurality of second feature vectors, a first projection matrix, and a second projection matrix, express the first latent vectors and the second latent vectors, and perform bayesian estimation with the first feature vectors, the second feature vectors, and a known the evaluation value as learning data, and calculate a posterior distribution of a parameter group including the first latent vectors, the second latent vectors, the first projection matrix, and the second projection matrix; and a predicting section configured to calculate a distribution of an unknown the evaluation value on a basis of the posterior distribution of the parameter group.. .
|Compression of decomposed representations of a sound field|
In general, techniques are described for obtaining decomposed versions of spherical harmonic coefficients. A device comprising one or more processors may be configured to perform the techniques, whereby the processors may be configured to obtain, from a bitstream, at least one of one or more vectors decomposed from spherical harmonic coefficients that were recombined with background spherical harmonic coefficients, wherein the spherical harmonic coefficients describe a sound field, and wherein the background spherical harmonic coefficients described one or more background components of the same sound field..
|Compensating for error in decomposed representations of sound fields|
In general, techniques are described for compensating for error in decomposed representations of sound fields. In accordance with the techniques, a device comprising one or more processors may be configured to quantize one or more first vectors representative of one or more components of a sound field, and compensate for error introduced due to the quantization of the one or more first vectors in one or more second vectors that are also representative of the same one or more components of the sound field..
|Method and apparatus for automatic speaker-based speech clustering|
Reliable speaker-based clustering of speech utterances allows improved speaker recognition and speaker-based speech segmentation. According to at least one example embodiment, an iterative bottom-up speaker-based clustering approach employs voiceprints of speech utterances, such as i-vectors.
|Extended subspace method for cross-talk mitigation in multi-parameter inversion|
An extended subspace method for inverting geophysical data to infer models for two or more subsurface physical properties, using gradients of an objective function as basis vectors for forming model updates. The extended set of basis vectors provides explicit mixing between gradient components corresponding to different medium parameters, for example p-wave velocity and an anisotropy parameter.
|Fatty alcohol forming acyl reductase (far) variants and methods of use|
The present disclosure provides methods useful for producing fatty alcohol compositions from recombinant host cells. The disclosure further provides fatty acyl-coa reductase (far) variant enzymes, polynucleotides encoding the far variant enzymes, and vectors and host cells comprising polynucleotides encoding the far variant enzymes..
|Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof|
The present invention generally relates to compositions, methods applications and screens used in functional genomics that focus on gene function in a cell and that may use vector systems and other aspects related to clustered regularly interspaced short palindromic repeats (crispr)-cas systems and components thereof. Provided are vectors and vector systems, some of which encode one or more components of a crispr complex, as well as methods for the design and use of such vectors.
|Nucleic acids for cloning and expressing multiprotein complexes|
The present invention relates to a nucleic acid containing at least one homing endonuclease site (he) and at least one restriction enzyme site (x) wherein the he and x sites are selected such that he and x result in compatible cohesive ends when cut by the homing endonuclease and restriction enzyme, respectively, and the ligation product of he and x cohesive ends can neither be cleaved by the homing endonuclease nor by the restriction enzyme. Further subject-matter of the present invention relates to a vector comprising the nucleic acid of the present invention, host cells containing the nucleic acid and/or the vector; a kit for cloning and/or expression of multiprotein complexes making use of the vector and the host cells, a method for producing a vector containing multiple expression cassettes, and a method for producing multiprotein complexes.
|Lentiviral vectors containing an mhc class i, mhc class ii, or b2 microglobulin upstream promoter sequence|
The present invention relates to the insertion of an mhc class i, mhc class ii, or β2 microglobulin upstream promoter sequence into a lentiviral vector to increase viral titers. The invention encompasses these vectors, methods of making the vectors, and methods of using them, including medicinal uses..
|Baculovirus expression systems|
The present invention relates to an optimized baculovirus construct useful for the production of virus (-like) particles or viral vectors, in particular viral vectors for gene therapy.. .
|Amino acid sequences for clinical remission of psoriasis and related diseases.|
Polypeptides comprising amino acid sequences of particulate antigens isolated from various species of leishmania protozoa, or immunogenic variants thereof, are disclosed for the treatment and clinical remission of cutaneous leishmaniasis, psoriasis, psoriatic arthritis, rheumatoid arthritis, atopic dermatitis, seborrheic dermatitis and skin papilloma. Also disclosed are nucleic acid sequences encoding such polypeptides, vectors incorporating such nucleic acid sequences, methods for genetically engineering microbial host cells to produce such polypeptides, and such recombinant microbial host cells.
|Novel serine protease variants|
The present disclosure provides novel variants of enzymes exhibiting serine protease activity; nucleic acid molecules encoding said proteases, vectors, host cells containing the nucleic acids and methods for preparation and producing such enzymes; compositions and complexes comprising at least one of the proteases; and methods for using such enzymes as a part of an immunoprotease, in particular for the treatment of cancer.. .
|Modified coagulation factor viia with extended half-life|
The present invention relates to the fields of factor vii (fvii) and factor viia (fviia) albumin linked polypeptides. More specifically, the invention relates to cdna sequences coding for human factor vii and factor viia and derivatives genetically fused to a cdna coding for human serum albumin which may be linked by oligonucleotides which code for intervening peptidic linkers such encoded derivatives exhibiting improved stability and extended functional plasma half-life, recombinant expression vectors containing such cdna sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives which do have biological activities of the unmodified wild type protein but having improved stability and prolonged shelf-life and processes for the manufacture of such recombinant proteins and their derivatives.
|Human beta-adrenergic receptor kinase polypeptide and methods|
Various embodiments of the invention provide human kinases and phosphatases (kpp) polypeptides and polynucleotides which identify and encode kpp. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists.
|Subfamily e simian adenoviruses a1321, a1325, a1295, a1309, a1316 and a1322 and uses thereof|
Recombinant vectors comprise simian adenovirus a1321 (sadv-a1321), sadv-a1325, sadv-a1295, sadv-a1309, sadv-a1316, and/or sadv-a1322 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus sadv-a1321, sadv-a1325, sadv-a1295, sadv-a1309, sadv-a1316, and/or sadv-a1322 gene(s) is also disclosed.
|Biologically active proteins having increased in vivo and/or in vitro stability|
The present invention provides unstructured recombinant polymers (urps) and proteins containing one or more of the urps. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities.
|Transformed higher order ambisonics audio data|
In general, techniques are described for obtaining one or more first vectors describing distinct components of a soundfield and one or more second vectors describing background components of the soundfield, both the one or more first vectors and the one or more second vectors generated at least by performing a transformation with respect to a plurality of spherical harmonic coefficients.. .
|Partial ciphertext updates using variable-length segments delineated by pattern matching and encrypted by fixed-length blocks|
A re-encryptor compares hashed digests of updated segments and original segments to located changed segments that must be re-encrypted. A new initialization vector is input to a block cipher engine for each changed segment.
|Method for four-path tree structured vector quantization|
Disclosed is a method for four-path tree structured vector quantization, comprising: (a) placing codebook vectors where magnitudes of vectors are arranged in order at lowermost nodes; (b) configuring upper nodes by averaging vector values of the lowermost adjacent four nodes; (c) calculating mean square errors to paths of the upper nodes (a, b, c, and d) corresponding to four paths from an input vector ‘x’; (d) presetting a threshold between 0 and 1 after the ‘(c)’; (e) calculating thresholds between the input vector ‘x’ and four paths ‘a’, ‘b’, ‘c’, and ‘d’, based on the mean square errors; and (f) comparing the thresholds calculated in the ‘(d)’ with the preset threshold to select a path having a threshold greater than the preset threshold, in which dynamic four-path tree structured vector quantization is used instead of conventional dynamic two-path tree structured vector quantization, thereby more efficiently and quickly searching a codebook.. .
|Virtual glasses try-on method and apparatus thereof|
Disclosed are virtual glasses try-on method and apparatus, and the apparatus includes an image capturing unit for capturing a user's image and a processing device for detecting a face image from the user's image, storing a glasses model, defining a first feature point of a lens of the glasses model and a second feature point at the center of a frame, and obtaining vertical vectors of the first and second feature points to find a third feature point. Two eye images are searched and binarized into a binarized picture that is divided into an eye area and a non-eye area.
|Efficient motion estimation for 3d stereo video encoding|
An efficient motion estimation method and apparatus for 3d stereo video encoding is described herein. In an embodiment of the method, an enhancement layer motion vector for a frame is determined by obtaining a motion vector of a co-located macroblock (mb) from the same frame of a base layer.
|Rendering a 3d shape|
A method for rendering a three-dimensional (3d) shape, including: obtaining an electronic document (ed) specifying the 3d shape; generating a two-dimensional (2d) polygon by projecting the 3d shape onto a 2d plane; selecting multiple control points on a surface of the 3d shape; calculating multiple normal vectors orthogonal to the surface at the multiple control points; determining multiple coordinates by projecting the multiple control points onto the 2d plane; fitting a polynomial based on at least the multiple coordinates and the normal vectors; applying a 3d lighting effect to the 2d polygon based on the polynomial; and outputting the 2d polygon with the 3d lighting effect.. .
|High resolution and high sensitivity three-dimensional (3d) cursor maneuvering device|
A three dimensional (3d) maneuvering device generates 3d data by irradiating a variably tinted two dimensional (2d) reference surface. The tri-stimuli color index data (e.g.
|Actuator cooling apparatus and method|
An injection molding apparatus comprising a heated manifold, an actuator comprised of an actuator housing containing a drive member interconnected to a valve pin having a drive axis, one or more heat convectors each heat convector comprised of a heat conductive leg disposed within a gap disposed between the manifold and a downstream end of the actuator housing and a heat conductive arm extending distally upstream and away from the gap such that heat is conducted from the leg to the arm upstream and away from the downstream end of the actuator housing.. .
|Mirnas useful to reduce lung cancer tumorigenesis and chemotherapy resistance and related compositions and methods|
Disclosed are compositions, such as nucleic acids, vectors, cells, animal models and the like, useful to reduce tumor growth, cancer cell migration and various other cancer pathologies associated with egfr (epidermal growth factor receptor) and met (the receptor tyrosine kinase for hepatocyte growth factors) dyregulation, particularly in non-small cell lung carcinoma.. .
|Information processing apparatus, information processing method, and program|
An information processing method is disclosed which includes the steps of: (a) calculating levels of similarity between a standard form vector as a comparison basis vector and each of a plurality of item characteristic vectors of the standard form which are characteristic of a plurality of items, the standard form vector being made up of n components individually representative of n attributes of each of the plurality of items, n being an integer of at least 1, step (a) further determining as the items to be recommended to a user a plurality of items corresponding to the item characteristic vectors of which the level of similarity satisfies a first condition; (b) determining one of the n attributes of the plurality of recommended items determined in step (a) as a common recommendation reason common to the plurality of recommended items when the determined attribute satisfies a second condition; and (c) controlling presentation to the user of either the plurality of recommended items determined in step (a) or information about the recommended items, together with the common recommendation reason determined in step (b).. .
|Method and apparatus for automatically identifying a fraudulent order|
A method and apparatus for automatically identifying a fraudulent order are disclosed. The method comprises: a model training phase which comprises: taking history orders, which have been determined as fraudulent or not, as training samples, and extracting characteristics from respective history orders to provide respective characteristic vectors for the history orders; and training an order identifying model using the characteristic vectors for respective history orders, and an order identifying phase which comprises: extracting characteristics from an order to be identified to provide a characteristic vector for the order to be identified, and inputting the characteristic vector for the order to be identified into the order identifying model to obtain therefrom a result of whether the order to be identified is fraudulent or not.
|Term translation acquisition method and term translation acquisition apparatus|
A term translation acquisition apparatus includes: a creation unit which creates a statistical model based on a set of input terms' context vectors, wherein the set of terms including at least two terms, are in the same source language and describe the same concept; and a ranking unit which uses the created statistical model to score terms in a target language that are considered as translation candidates for the concept.. .
|Sensing vector selection in a cardiac stimulus device with postural assessment|
Methods, implantable medical devices and systems configured to perform analysis of captured signals from implanted electrodes to identify cardiac arrhythmias. In an illustrative embodiment, signals captured from two or more sensing vectors are analyzed, where the signals are captured with a patient in at least first and second body positions.
|System and method for controlling electrical stimulation based on lowest operable voltage multiplier for use with implantable medical device|
Techniques are provided for use with implantable devices equipped with programmable voltage multipliers (including voltage dividers.) candidate pulse widths are determined for selected voltage multipliers and stimulation vectors. Each candidate pulse width corresponds to a lowest pulse energy sufficient to achieve capture within the tissues of the patient (subject to a safety margin) using the selected vector and using the corresponding voltage multiplier.
|Method and system for providing visual guidance to an operator for steering a tip of an endoscopic device towards one or more landmarks in a patient|
Landmark directional guidance is provided to an operator of an endoscopic device by displaying graphical representations of vectors adjacent a current image captured by an image capturing device disposed at a tip of the endoscopic device and being displayed at the time on a display screen, wherein the graphical representations of the vectors point in directions that the endoscope tip is to be steered in order to move towards associated landmarks such as anatomic structures in a patient.. .
|Novel sugar alcohol-based compositions for delivering nucleic acid-based drugs in vivo and in vitro|
This invention relates to a composition and its use for formulating nucleic acid-based drugs/vaccines with sugar alcohol compositions into complexes for both in-vitro and in-vivo delivery. Particularly, the present invention includes the ingredients and processes necessary for formulating therapeutic and pharmaceutical nucleic acid compositions, such as mirna, microrna precursors, shrnas, sirnas, ribozymes, antisense rnas/dnas, rna-dna hybrids and dna vectors/vaccines, with glycylated sugar alcohols/sugars into delivery complexes, which can then be absorbed by cells in vivo and in vitro via active endocytosis.
|Isoform-selective inhibitors and activators of pde3 cyclic nucleotide phosphodiesterases|
The present invention concerns methods and compositions related to type 3 phosphodiesterases (pde3). Certain embodiments concern isolated peptides corresponding to various pde3a isoforms and/or site-specific mutants of pde3a isoforms, along with expression vectors encoding such isoforms or mutants.
|Multivalent fibronectin based scaffold domain proteins|
The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications.
|Large commercial scale lentiviral vector production system and vectors produced thereby|
In accordance with the present invention, a method for increasing the yield of rlv vector particles comprising a trans gene encoding a therapeutic protein or fragment thereof is disclosed. In one approach, cells are transfected with plasmids encoding the necessary components for rlv production using a calcium chloride transfection mix at ph 7.1 wherein the calcium chloride and plasmids form a complex which is added to the cells at a constant speed.
|Reprogramming immortalized b cells|
Methods and composition for providing induced pluripotent stem (ips) cells are provided. For example, in certain aspects methods including reprogramming b lymphocytes transformed by episomal vectors such as epstein-barr virus-based vectors are described.
|Baculovirus system for the expression of a gene therapy vector|
The invention concerns a recombinant baculovirus genome useful for the expression of gene therapy vectors by means of a single infection.. .
|Lipase variants and polynucleotides encoding same|
The present invention relates to lipase variants and methods of obtaining them. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..