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Vectors patents



      
           
This page is updated frequently with new Vectors-related patent applications. Subscribe to the Vectors RSS feed to automatically get the update: related Vectors RSS feeds. RSS updates for this page: Vectors RSS RSS


Transgenic birds that produce chimeric human immunoglobulins

Systems and methods for source signal separation

Date/App# patent app List of recent Vectors-related patents
10/23/14
20140317786
 Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same patent thumbnailPolypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
10/23/14
20140317778
 Nucleic acid molecules encoding enzymes that confer disease resistance in jute patent thumbnailNucleic acid molecules encoding enzymes that confer disease resistance in jute
The invention further relates to vectors, host cells, seeds, and plants comprising such a nucleic acid molecule. One aspect of the invention is an isolated antibody or antigen binding fragment thereof that specifically binds to a polypeptide molecule of the present invention.
10/23/14
20140317765
 Transgenic birds that produce chimeric human immunoglobulins patent thumbnailTransgenic birds that produce chimeric human immunoglobulins
The invention relates to transgenic birds capable of producing chimeric immunoglobulins, with a combination of human and avian sequence, in their b cells. In some embodiments, the birds are chickens.
10/23/14
20140316771
 Systems and methods for source signal separation patent thumbnailSystems and methods for source signal separation
A method includes receiving an input signal comprising an original domain signal and creating a first window data set and a second window data set from the signal, wherein an initiation of the second window data set is offset from an initiation of the first window data set, converting the first window data set and the second window data set to a frequency domain and storing the resulting data as data in a second domain different from the original domain, performing complex spectral phase evolution (cspe) on the second domain data to estimate component frequencies of the first and second window data sets, using the component frequencies estimated in the cspe, sampling a set of second-domain high resolution windows to select a mathematical representation comprising a second-domain high resolution window that fits at least one of the amplitude, phase, amplitude modulation and frequency modulation of a component of an underlying signal wherein the component comprises at least one oscillator peak, generating an output signal from the mathematical representation of the original signal as at least one of: an audio file; one or more audio signal components; and one or more speech vectors and outputting the output signal to an external system.. .
10/23/14
20140316758
 System for diagnosing bloodflow characteristics, method thereof, and computer software program patent thumbnailSystem for diagnosing bloodflow characteristics, method thereof, and computer software program
This system is a computer-based system for analyzing a blood flow at a target vascular site of a subject by means of a computer simulation, having a three-dimensional shape extraction unit, by a computer, for reading a captured image at the target vascular site and generating three-dimensional data representing a shape of a lumen of the target vascular site; a fluid dynamics analysis unit, by a computer, for determining state quantities (pressure and flow velocity) of blood flow at each position of the lumen of the target vascular site by means of computation by imposing boundary conditions relating to blood flow to the three-dimensional shape data; a blood flow characteristic determination unit for determining, from the state quantities of the blood flow determined by the fluid dynamics analysis unit, a wall shear stress vector at each position of the lumen wall surface of the target vascular site, determining relative relationship between a direction of the wall shear stress vector at a specific wall surface position and directions of wall shear stress vectors at wall surface positions surrounding the specific wall surface position, and from the morphology thereof, determining characteristics of the blood flow at the specific wall surface position and outputting the same as a determined result; and a display unit, by a computer, for displaying the determined result of the blood flow characteristic which is graphically superposed onto a three-dimensional shape model.. .
10/23/14
20140315822
 High mast2-affinity polypeptides and uses thereof patent thumbnailHigh mast2-affinity polypeptides and uses thereof
The invention relates to polypeptides containing a cytoplasmic domain ending with a mast-2 binding domain, from 11 to 13 residues, the first two residues of which are s and w, and the last four residues of which are q, t, r and l, said polypeptides presenting a high affinity for the pdz domain of the human mast2 protein. The invention also relates to polynucleotides, vectors, lentiviral particles, cells as well as compositions comprising the same.
10/23/14
20140315565
 Frequency selection method and cognitive wireless system patent thumbnailFrequency selection method and cognitive wireless system
A frequency to be used in a cognitive wireless system is determined appropriately. A db apparatus manages white spaces (ws) for each frequency, and calculates and reports, to a mobile terminal, ws vectors (distances from a mobile terminal location to an interference area in the four directions, north, south, east and west) for each frequency.
10/23/14
20140315314
 Engineered listeria and methods of use thereof patent thumbnailEngineered listeria and methods of use thereof
The invention provides a bacterium containing a polynucleotide comprising a nucleic acid encoding a heterologous antigen, as well as fusion protein partners. Also provided are vectors for mediating site-specific recombination and vectors comprising removable antibiotic resistance genes..
10/23/14
20140315294
 Scalable lentiviral vector production system compatible with industrial pharmaceutical applications patent thumbnailScalable lentiviral vector production system compatible with industrial pharmaceutical applications
The present invention relates to the industrialization of the production of recombinant lentiviral vectors in order to manufacture sufficient materials for therapeutic applications such as gene therapy and/or dna vaccination, for use in clinical trials and/or commercial use.. .
10/23/14
20140315272
 Novel lipolytic enzyme lip2 patent thumbnailNovel lipolytic enzyme lip2
The present invention provides a novel nucleic acid sequence, designated lip2, encoding a lipolytic enzyme and the corresponding encoded amino acid sequences. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding at least one novel lipolytic enzyme, recombinant lipolytic enzyme proteins and methods for producing the same..
10/23/14
20140315269
Use of recombinant type iii "polyketide synthases" (pks iii) of marine brown algae
The present invention relates to a method for producing polyphenol compounds, i.e. Phloroglucinol or one of its derivatives, with a polyketide synthase of type iii (pksiii) from a brown marine alga.
10/23/14
20140315234
Method to generate dopaminergic neurons from mouse and human cells
The present invention relates to a method for reprogramming a differentiated non neuronal cell into a dopaminergic neuron comprising the step of inducing the expression in the differentiated non neuronal cell of at least the protein encoded by the mash1 human gene or orthologues thereof and the protein encoded by the nurr1 human gene or orthologues thereof, expression vectors, reprogrammed dopaminergic neuron and uses thereof.. .
10/23/14
20140314809
Malaria antigen screening method
The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (apcs) in vitro or to an animal in vivo.
10/23/14
20140314761
Polypeptides having antiviral activity and methods for use thereof
A polypeptide is provided that comprises an actinohivin variant polypeptide having an amino acid sequence selected from seq id nos: 4-12. The polypeptide can be provided as part of a fusion protein that includes the actinohivin variant polypeptide and either a fragment crystallizable domain of an antibody (fc), a fragment antigen-binding domain of an antibody (fab), or a single chain variable fragment of an antibody (scfv).
10/23/14
20140314717
Simian (gorilla) adenovirus or adenoviral vectors and methods of use
The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pix protein, dna polymerase protein, penton protein, hexon protein, and/or fiber protein.. .
10/23/14
20140314323
Optimized fast hessian matrix computation architecture
Methods and systems of recognizing images may include an apparatus having a hardware module with logic to, for a plurality of vectors in an image, determine a first intermediate computation based on even pixels of an image vector, and determine a second intermediate computation based on odd pixels of an image vector. The logic can also combine the first and second intermediate computations into a hessian matrix computation..
10/23/14
20140314301
Color decomposition in histology
The method according to the invention generates a color decomposition of histological tissue image data into density maps, where each density map corresponds to the portion of the original image data that contains one stain/tissue combination. After a microscope captures histological tissue image data from a tissue sample that has been stained with at least one stain, the said stain or stains being light absorbent, the method derives from the histological tissue image data a color mixing matrix with the columns of the matrix being color reference vectors.
10/23/14
20140314295
Image processing method and apparatus and program
An image processing method for registering first and second images including the same subject is provided. The method includes the repeating the following steps multiple times: a first step including determining feature vectors related to gradients of pixels values at coordinates on the first and second images for each of the coordinates, a second step including calculating for all mutually corresponding coordinates on the first and second images, correlation values each equivalent to a value obtained by an n-th (where n is a natural number) power of an absolute value of an inner product of the feature vectors at the coordinates and determining an evaluation value including an integrated value of the correlation values calculated for each of the coordinates, and a third step including changing the second image in such that the evaluation value becomes larger..
10/23/14
20140314290
Positioning anatomical landmarks in volume data sets
Certain embodiments provide a computer apparatus operable to carry out a data processing method to position a set of anatomical landmarks in a three-dimensional image data set of a part or all of a patient, comprising: providing a trained supervised machine learning algorithm which has been trained to place each of the set of anatomical landmarks; applying the supervised machine learning algorithm to place the set of anatomical landmarks relative to the data set; providing a trained point distribution model, including a mean shape and a covariance matrix, wherein the mean shape represents locations of the set of landmarks in a variety of patients; and applying the point distribution model to the set of landmarks with the locations output from the supervised machine learning algorithm by: removing any landmarks whose locations have an uncertainty above a threshold with reference to the mean shape and covariance matrix; followed by: an optimisation of the locations of the remaining landmarks by maximising joint likelihood that a new shape, derived from linear combinations of eigenvectors of the covariance matrix, is plausible.. .
10/23/14
20140314147
Harmonized inter-view and view synthesis prediction for 3d video coding
There are disclosed various methods, apparatuses and computer program products for video encoding. The type of prediction used for a reference picture index may be signaled in the video bit-stream.
10/23/14
20140313339
Vision system for vehicle
A vision system for a vehicle includes an image sensor disposed at a subject vehicle and having a field of view exterior of the subject vehicle. A control is operable to process image data captured by the image sensor to detect an object exterior of the subject vehicle.
10/16/14
20140310830
Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a crispr complex, as well as methods for the design and use of such vectors.
10/16/14
20140310536
Storage device assisted inline encryption and decryption
Various features pertain to inline encryption and decryption. In one aspect, inline read/write operations are performed by configuring an off-chip storage device to provide parameters to facilitate inline encryption/decryption of data by a host storage controller of a system-on-a-chip (soc.) the parameters provided by the storage device to the host storage controller include an identifier that is the same for read and write operations for a particular block of data but differs from one block of data to another.
10/16/14
20140310279
Management of file storage locations
The embodiments described may be directed toward a file management system for managing a file folder location, a method for managing one or more data clusters, and a method of recommending a file storage location. The method of recommending a file storage location may also include plotting one or more data points onto one or more vectors.
10/16/14
20140310097
Information processing system, information processing method, communications terminals and control method and control program thereof
Advertisement information relating to an object is provided in real time, while capturing images of the object. M first local features which are respectively feature vectors from one dimension to i dimensions are stored in association with an object, n feature points are extracted from a video picture, n second local features which are respectively feature vectors from one dimension to j dimensions are generated, the smaller number of dimensions is selected, of the number of dimensions i and the number of dimensions j, and an object is recognized to be present in the video picture and advertisement information relating to that object is provided when determination is made that at least a prescribed ratio of the m first local features of the selected number of dimensions corresponds to the n second local features of the selected number of dimensions..
10/16/14
20140309729
Devices and methods for treating valvular regurgitation
A system for treating mitral valve regurgitation includes a tensioning device having a plurality of helical anchors and a tensioning filament. One embodiment of the invention includes a method for attaching a tensioning device to the annulus of a mitral valve in a trans-leaflet configuration, and applying a tension force to the tension filament in order to exert force vectors on the annulus, thereby reshaping the mitral valve annulus so that the coaption of the anterior and posterior leaflets of the mitral is improved during ventricular contraction..
10/16/14
20140309543
Devices, systems and methods to perform arrhythmia discrimination based on the atrial and ventricular activation times
Described herein are implantable systems and devices, and methods for use therewith, that can be used to perform arrhythmia discrimination based on activation times. A plurality of different sensing vectors are used to obtain a plurality of iegms that collectively enable electrical activations to be detected in the left atrial (la) chamber, the right atrial (ra) chamber, and at least one ventricular chamber of a patient's heart.
10/16/14
20140309289
Combination anti-hiv vectors, targeting vectors, and methods of use
Recombinant lentiviral vectors containing at least: a lentiviral backbone comprising essential lentiviral sequences for integration into a target cell genome; a nucleic acid encoding a ccr5 rnai; and an expression control element that regulates expression of the nucleic acid encoding the ccr5 rnai element, are provided by this invention. In an alternative aspect, the vector also contains polynucleotides encoding trim5 alpha and hiv tar decoy sequences along with gene expression regulation elements such as promoters operatively linked to the polynucleotides.
10/16/14
20140309163
Fibronectin based scaffold domain proteins that bind to myostatin
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, copd, chronic kidney disease, heart failure, myocardial infarction, and fibrosis.
10/16/14
20140308731
Novel cytochrome p450 enzymes from sorghum bicolor
Two novel cytochrome p450 genes are isolated from sorghum, each gene encoding a protein having pentadecatrienyl resorcinol hydroxylase activity. Expression vectors containing these sequences are made and used to elevate levels of pentadecatrienyl resorcinol hydroxylase in transgenic cells and organisms..
10/16/14
20140308725
Polypeptides having glucoamylase activity and polynucleotides encoding same
The present invention provides isolated polypeptides having glucoamylase activity, catalytic domains, and polynucleotides encoding the polypeptides, catalytic domains. The invention also provides nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains..
10/16/14
20140308705
Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
10/16/14
20140308672
Dna polymerases with increased 3'-mismatch discrimination
Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods.
10/16/14
20140308288
Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
An antibody of the invention interacts with human dr5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-dr5 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated.
10/16/14
20140308276
Anti-ox40 antibodies and methods of using the same
Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human ox40 are disclosed. Preferred antibodies have high affinity for ox40 receptor and activate the receptor in vitro and in vivo.
10/16/14
20140308267
Neurotoxins exhibiting shortened biological activity
The present invention relates to the pharmaceutical field. Specifically, it contemplates a polynucleotide encoding a neurotoxin polypeptide exhibiting a reduced duration of the biological effect in a subject, wherein said polypeptide comprises at least one e3 ligase recognition motif in the light chain, wherein said e3 ligase recognition motif is preferably a binding motif for the e3 ligase mdm2.
10/16/14
20140308247
Vectors conditionally expressing protein
This invention relates to the field of therapeutics. Most specifically, the invention provides methods of generating conditionally expressing one or more proteins under the control of a gene expression modulation, system in the presence of activating ligand and uses for therapeutic purposes in animals.
10/16/14
20140307938
Techniques for generating a representative image and radiographic interpretation information for a case
A technique for generating a representative image representing a case and radiographic interpretation information for each case includes calculating wavelet features of a plurality of images that have been taken and stored in the past. The calculated wavelet features and extracted keywords are stored in association with the stored images.
10/16/14
20140307815
Systems and methods for beamforming in a massive mimo system
Embodiments provide systems and methods for enabling a first transceiver to learn beamforming weights (e.g., eigen beamforming weights) to a second transceiver, without any pilot signaling or explicit beamforming weight signaling from the second transceiver. In another embodiment, beamforming weight vectors to enable a multi-symbol spatial rate can be learned by the first transceiver..
10/16/14
20140307794
Apparatus and method for motion estimation for variable block sizes
A motion estimation apparatus and method are disclosed. The motion estimation apparatus includes processing element (pe) array units, sub-sad calculation units, motion vector calculation units, and a minimum motion vector selector.
10/16/14
20140307783
Method and apparatus for motion vector determination in video encoding or decoding
The motion vector determining method involves determining a candidate motion vector list comprising motion vectors of a plurality of candidate blocks referred so as to predict a motion vector of a current block, when a reference image of a first candidate block from among the plurality of candidate blocks is different from a reference image of the current block, determining whether or not to use a motion vector of the first candidate block from the candidate motion vector list, based on whether each of the reference image of the current block and the reference image of the first candidate block is a short-term reference image or a long-term reference image, and determining the motion vector of the current block by using a candidate motion vector selected from among the motion vectors comprised in the candidate motion vector list.. .
10/16/14
20140307275
To generate an image
A method to generate an image in which a plurality of offset vectors for portions of a first image are determined by comparing the similarity of the portions to portion of a second image.. .
10/16/14
20140307120
Method to improve accuracy and reliability of motion estimated with phase correlation
A method of improving accuracy and reliability of motion estimation is described herein. In one aspect, a 2d neighborhood of phase correlation peak is approximated with an outer-product of two 1d vectors to eliminate the sub-pixel error.
10/16/14
20140307119
Method and apparatus for image noise filtering
Methods and apparatus for filtering noise of low frequency from an image of the surface characteristics of an object expressed with reference to orthogonal first and second axis and obtained with linear light scanning, involve calculating a difference between pixel values of an image column vector along the second axis adjacent a selected reference image column vector and respective pixel values of the selected reference image column vector to obtain a pixel difference vector. The pixel difference values not mainly associated with a corresponding atypical change of surface characteristics as compared with noise are then selected, and a mean value from the selected pixel difference values are calculated as an estimated value of the noise.
10/16/14
20140306960
Display processing method and apparatus
A disclosed method includes: performing a processing for adjusting positions of voxel data for an object and data of a geometric model for the object; calculating, for each voxel included in a range defined by a cross section among plural voxels that are included in the voxel data, a voxel value of the voxel from physical values in elements of the geometric model, which are included in a predetermined range of the voxel, based on a relation between the cross section and vectors; and rendering an image by using the voxel value calculated for each voxel. A vector of the vectors is set for one element of plural elements included in the geometric model, the vectors represent a direction of an inner structure of the object, and the cross section is set for the voxel data and the geometric model data..
10/16/14
20140306901
Method of processing touch-sensor data and apparatus for performing the same
A method of processing touch-image data includes calculating a plurality of motion vectors using a plurality of low-resolution touch-image data frames, aligning sensing data corresponding to an object detected in the low-resolution touch-image data frames using the motion vectors to generate an overlapped touch-image data frame, generating high-resolution data corresponding to the detected object using the overlapped touch-image data frame and detecting the touch position and generating touch position data of the detected object using the high-resolution touch position data corresponding to the detected object.. .
10/09/14
20140304859
Polypeptides having endoglucanase activity and polynucleotides encoding same
Provided are isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
10/09/14
20140303355
Humanized anti-factor d antibodies and uses thereof
The invention relates to humanized anti-human factor d monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease..
10/09/14
20140303077
Albumin fusion proteins
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells.
10/09/14
20140302586
Variants of a family 44 xyloglucanase
The present invention relates to variants of a parent xyloglucanase. The present invention also relates to polynucleotides encoding the variant xyloglucanases and to nucleic acid constructs, vectors, and host cells comprising the polynucleotide..
10/09/14
20140302561
3s-rhamnose-glucuronyl hydrolase, method of production and uses
The present invention relates in particular to proteins, coding nucleic acid sequences for same, vectors comprising said coding sequences, a method for producing said proteins, and an oligosaccharide hydrolysis method using same. In particular, the invention relates to the protein of sequence seq id no.
10/09/14
20140302530
Cmv glycoproteins and recombinant vectors
This invention also relates to recombinant vectors expressing one or more of the human cmv (hcmv) glycoproteins us2, us3, us6 and us11 or corresponding functional rhesus cmv (rhcmv) homologues rh182, rh184, rh185 or rh189, methods of making them, uses for them, expression products from them, and uses for the expression products. This invention also relates to recombinant cytomegalovirus vectors vectors lacking one or more of the glycoproteins, methods of making them, uses for them, expression products from them, and uses for the expression products..
10/09/14
20140302512
Genotoxicity testing
The present invention relates to methods for detecting for the presence of an agent that putatively causes or potentiates dna damage comprising subjecting a cell (containing a dna sequence encoding gaussia luciferase (gluc) reporter protein operatively linked to a human gadd45α gene promoter and a human gadd45α gene regulatory element arranged to activate expression of the dna sequence in response to dna damage) to an agent; and monitoring the expression of the gluc reporter protein from the cell. The invention also concerns expression cassettes, vectors and cells which may be used according to such a method and also modified media that may be employed in assays and in preferred embodiments of the method of the invention..
10/09/14
20140302508
Dna polymerases with increased 3'-mismatch discrimination
Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods.
10/09/14
20140302507
Dna polymerases with increased 3'-mismatch discrimination
Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods.
10/09/14
20140302080
Stabilized human immunodeficiency virus (hiv) envelope (env) trimer vaccines and methods of using same
The invention features stabilized human immunodeficiency virus (hiv) envelope (env) trimers. The invention also features vaccines, nucleic acids, and vectors to deliver and/or facilitate production of the stabilized hiv env trimers.
10/09/14
20140302076
Immunogenic compositions and methods therefor
The present invention provides compositions relating to viral capsomeres which comprise foreign immunogenic sequences for use in pharmaceutical compositions and methods of producing such compositions, and related isolated or purified protein and nucleic acid molecules, vectors, host cells, compositions, and methods of use to augment an immune response, immunise an animal and prophylactically or therapeutically treat a disease, disorder or condition. The viral capsomere may be derived from a polyomavirus and comprise an immunogen of interest at the n-terminus and further at the c-terminus and/or at one or more exposed loops of the capsomere..
10/09/14
20140302064
Optimized anti-cd3 variable regions
The present invention is directed to optimized anti-cd3 variable sequences for use in a variety of bispecific formats, including those that utilize scfv components. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector.
10/09/14
20140302054
Anti-gpr49 antibodies
Described herein are antibodies against gpr49 and uses of such antibodies. Various aspects relate to monoclonal, humanized, or fully human antibodies against gpr49, hybridomas or other cell lines expressing such antibodies, nucleic acids and vectors comprising nucleic acids encoding for such antibodies..
10/09/14
20140302049
Anti-gpr49 antibodies
Described herein are to antibodies against gpr49 and uses of such antibodies. Various aspects relate to monoclonal, humanized, or fully human antibodies against gpr49, hybridomas or other cell lines expressing such antibodies, nucleic acids and vectors comprising nucleic acids encoding for such antibodies..
10/09/14
20140302033
Albumin binding antibodies and binding fragments thereof
A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in seq id no: 1 or seq id no:2 and/or comprising a light chain variable domain having the sequence given in seq id no:3 or seq id no:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in seq id no: 1 and seq id no:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in seq id no: 2 and seq id no:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides.
10/09/14
20140301992
Compositions, methods and uses for treating solid tumors using lcmv-gp-vsv pseudotype vectors
Embodiments of the present invention relate to compositions and methods for producing recombinant vsv viruses. In accordance with these embodiments, viral vectors can include a glycoprotein gp of the lymphocyte choriomeningitis virus (lcmv) instead of the g protein of the vsv.
10/09/14
20140301974
Extended recombinant polypeptides and compositions comprising same
The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (xten), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.. .
10/09/14
20140301883
Method and apparatus for producing three-dimensional work pieces
A method for producing three-dimensional work pieces comprises the steps of supplying gas to a process chamber accommodating a carrier and a powder application device, applying a layer of raw material powder onto the carrier by means of the powder application device, selectively irradiating electromagnetic or particle radiation onto the raw material powder applied onto the carrier by means of an irradiation device, discharging gas containing particulate impurities from the process chamber, and controlling the operation of the irradiation device by means of a control unit such that a radiation beam emitted by at least one radiation source of the irradiation device is guided over the layer of raw material powder applied onto the carrier according to a radiation pattern containing a plurality of scan vectors.. .
10/09/14
20140300647
Scaling vector objects having arbitrarily complex shapes
Scaling arbitrarily complex graphical objects is described by superimposing a grid of four guide lines on a graphical object defined by one or more vectors. The guide lines define nine grid sections.
10/09/14
20140300606
Drawing device, drawing method, and drawing program
A drawing device includes an input unit, a first vector calculation unit, a second vector calculation unit, and a display control unit. The input unit accepts user input.
10/09/14
20140298887
Wheeled vehicle rollover performance testing system
This invention is for a simple, dynamic test device and its use to assess a wheeled vehicle's dynamic performance leading to a rollover including such conditions as a curb tripped rollover, a vehicle's occupant restraint performance before and during the first roll, the motion of the vehicle's occupants before and during a rollover, and the vehicle's occupant protection performance in a rollover including its roof crush resistance. It does so by carrying a vehicle over a horizontal circular path at a speed sufficient that the centrifugal force on the vehicle will cause it to roll.
10/02/14
20140298502
Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
The amino acid and nucleic acid sequences of a Δ5-desaturase enzyme and a Δ8-desaturase enzyme are disclosed. The nucleic acid sequences can be used to design recombinant dna constructs and vectors.
10/02/14
20140298351
Parallel operation method and information processing apparatus
An information processing apparatus assigns the calculation of a first submatrix included in a matrix including zero elements and non-zero elements to a first thread and the calculation of a second submatrix included in the matrix to a second thread. The information processing apparatus compares the distribution of non-zero elements in the rows or columns of the first submatrix with the distribution of non-zero elements in the rows or columns of the second submatrix.
10/02/14
20140298049
Digital signal transition counters for digital integrated circuits
A digital integrated circuit may include a digital data processing circuit having multiple signal lines that each go through signal transitions during operation of the digital data processing circuit. A digital counter circuit may count the combined number of signal transitions that take place on at least two of the multiple signal lines during operation of the digital circuit.
10/02/14
20140296932
Systems and methods for sensing vector selection in an implantable medical device
Methods and devices for sensing vector analysis in an implantable cardiac stimulus system. In an illustrative example, a first sensing vector is analyzed to determine whether it is suitable, within given threshold conditions, for use in cardiac event detection and analysis.
10/02/14
20140296930
Cardiac-safe electrotherapy method and apparatus
A multi-modal electrotherapy apparatus including circuitry for administering defibrillation therapy and for administering medium voltage therapy (mvt) adapted to reduce the side effects of mvt. The electrotherapy apparatus is configured to selectively deliver mvt to vectors not involving the ventricles and defibrillation therapy to vectors involving the ventricles.
10/02/14
20140296836
Gold-in-silicon nanoassembly for thermal therapy and methods of use
The present invention provides methods and compositions for the nanotechnology-based therapy of one or more mammalian diseases. Disclosed are gold-in-porous silicon nanoassemblies that are effective in the targeted and localized treatment of one or more human hyperproliferative disorders, including, for example, cancer of the breast.
10/02/14
20140296326
Epidermal growth factor receptor (egfr) and methods of use in adenoviral-associated virus type 6 (aav6) transduction
Comparative gene analysis (cga) was combined with pathway visualization software to identify a positive correlation between aav6 transduction and epidermal growth factor receptor (egfr) expression. It was found that egfr is necessary for vector internalization and functions as a co-receptor for aav6.
10/02/14
20140296324
Vectors harboring toxic genes, methods and uses therefor
The present disclosure describes nucleic acids, and viruses comprising such nucleic acids, for growing a toxic gene in an insect cell. These nucleic acids comprise a sequence encoding a toxic polypeptide, and an intron that interrupts the sequence, whereby the intron is spliced in mammalian cells but not in insect cells.
10/02/14
20140296101
Secreted proteins and uses thereof
The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies.
10/02/14
20140296093
Use of multiple recombination sites with unique specificity in combinational cloning
The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites with unique specificity.


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