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Vascular patents



      
           
This page is updated frequently with new Vascular-related patents. Subscribe to the Vascular RSS feed to automatically get the update: related Vascular RSS feeds.

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Date/App# patent app List of recent Vascular-related patents
04/17/14
20140107935
 Method and system for patient-specific modeling of blood flow patent thumbnailnew patent Method and system for patient-specific modeling of blood flow
Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data.
04/17/14
20140107773
 Methods and devices for repair or replacement of heart valves or adjacent tissue without the need for full cardiopulmonary support patent thumbnailnew patent Methods and devices for repair or replacement of heart valves or adjacent tissue without the need for full cardiopulmonary support
Methods and systems for endovascular, endocardiac, or endoluminal approaches to a patient's heart to perform surgical procedures that may be performed or used without requiring extracorporeal cardiopulmonary bypass. Furthermore, these procedures can be performed through a relatively small number of small incisions.
04/17/14
20140107771
 Assembly comprising a stabiliser and an instrument to be positioned in or around a passage surrounded by body tissue patent thumbnailnew patent Assembly comprising a stabiliser and an instrument to be positioned in or around a passage surrounded by body tissue
An assembly having a stabiliser and an instrument to be positioned in or around a passage surrounded by body tissue, in particular vascular tissue. The stabiliser is provided with one or more suction mouths running in the shape of a loop, which suction mouths can be operationally connected to suction means in order to suck tightly to tissue close to and around said passage, which may still have to be made.
04/17/14
20140107677
 Device and method for removing tissue inside a body vessel patent thumbnailnew patent Device and method for removing tissue inside a body vessel
An intravascular tissue removal tool has an elongated flexible sheath with a proximal end, a distal end, and a lumen extending from the proximal end to the distal end, the lumen having a distal lumen diameter near the distal end; cutting elements extending into the lumen near the distal end of the flexible sheath; a forceps having an open state and a closed state, and further having an extended position relative to the flexible sheath, in which the forceps is located substantially outside the flexible sheath near the distal end and a retracted position relative to the flexible sheath, in which the forceps is located substantially inside the flexible sheath; and an elongated actuation member being attached to the forceps for switching the forceps between the open state and the closed state and for moving the forceps between the extended state and the retracted state.. .
04/17/14
20140107664
 Systems and methods for removal of intravascular leads patent thumbnailnew patent Systems and methods for removal of intravascular leads
Systems and methods for extraction of implanted articles are disclosed. According to aspects illustrated herein, there is provided a system for extraction of an implanted article that includes an elongated member, guide member disposed at a distal section of the elongated member and having a pathway in substantially parallel relationship to the elongated member, through which pathway an implanted article can be accommodated, and a cutting mechanism, situated between the distal section of the elongated member and the guide member, for severing a fibrous adhesion about the implanted article to allow the implanted article to be extracted..
04/17/14
20140107576
 Apparatus for left-side installation of tunneled vascular catheters patent thumbnailnew patent Apparatus for left-side installation of tunneled vascular catheters
An apparatus for installation of a tunneled vascular catheter into a patient's right atrium from the left side of their upper body. The apparatus comprises a dilator and a peel-away sheath.
04/17/14
20140107575
 Balloon catheter patent thumbnailnew patent Balloon catheter
This is a balloon catheter having at least two lumens. One of the lumens is a large working lumen.
04/17/14
20140107513
 Internet-based system for evaluating ecg waveforms to estimate the degree of coronary blockage patent thumbnailnew patent Internet-based system for evaluating ecg waveforms to estimate the degree of coronary blockage
The present invention provides an improved, internet-based system that seamlessly collects cardiovascular data from a patient before, during, and after a procedure for ep or an id. During an ep procedure, the system collects information describing the patient's response to pes and the ablation process, ecg waveforms and their various features, hr and other vital signs, hr variability, cardiac arrhythmias, patient demographics, and patient outcomes.
04/17/14
20140107511
 Internet-based system for evaluating ecg waveforms to determine the presence of p-mitrale and p-pulmonale patent thumbnailnew patent Internet-based system for evaluating ecg waveforms to determine the presence of p-mitrale and p-pulmonale
The present invention provides an improved, internet-based system that seamlessly collects cardiovascular data from a patient before, during, and after a procedure for ep or an id. During an ep procedure, the system collects information describing the patient's response to pes and the ablation process, ecg waveforms and their various features, hr and other vital signs, hr variability, cardiac arrhythmias, patient demographics, and patient outcomes.
04/17/14
20140107509
 Internet-based system for collecting and analyzing data before, during, and after a cardiovascular procedure patent thumbnailnew patent Internet-based system for collecting and analyzing data before, during, and after a cardiovascular procedure
The present invention provides an improved, internet-based system that seamlessly collects cardiovascular data from a patient before, during, and after a procedure for ep or an id. During an ep procedure, the system collects information describing the patient's response to pes and the ablation process, ecg waveforms and their various features, hr and other vital signs, hr variability, cardiac arrhythmias, patient demographics, and patient outcomes.
04/17/14
20140107501
new patent Wireless multi-sensor platform for continuous real-time monitoring of cardiovascular respiratory dynamics
A set of vectorcardiogram leads attach to a patient and a signal conditioning circuit receives a plurality of analog signals from the plurality of vectorcardiogram leads. An analog to digital converter that transforms the conditioned analog signals into digital signals and a processor transforms the digital vectorcardiogram signals into electrocardiogram signals..
04/17/14
20140107492
new patent Mechanical scanning ultrasound transducer with micromotor
A system for use with ultrasound procedures including an ultrasound control and/or imaging system which has a microminiature motor, a rotatable reflector and a stationary ultrasound transducer. The transducer may be placed between the motor and the reflector, so as to eliminate the need for placement of wires or other artifact-creating items in the path of ultrasound signals.
04/17/14
20140107490
new patent Feedback/registration mechanism for ultrasound devices
Among other things, there is disclosed structure and methods for registering images obtained through internal (e.g. Intravascular) ultrasound devices.
04/17/14
20140107431
new patent Systems and method for health screening for vascular disease
An angiography system and method comprising of an imaging system for imaging arteries, a processor for processing image data for at least one artery of a participant and an output comprising the image of the artery, a reference image for the artery and physiological data and indexes of the participant.. .
04/17/14
20140107332
new patent Series of drugs using photofrin to catalyze decomposition of hydrogen peroxide
The present invention relates to a series of new drugs which refer to chemical series capable of catalyzing the decomposition of h2o2 to generate singlet oxygen (1o2). The drugs relate to therapeutic mechanisms, different from traditional photodynamic therapy, in which the specific affinity of photofrin to focus, such as tumors, vascular plaques and skin diseases is utilized.
04/17/14
20140107206
new patent Omega-3 pentaenoic acid compositions and methods of use
Orally administrable composition comprising fatty acids comprising omega-3-fatty acids, salts or derivatives thereof are provided. These compositions can be used for the treatment or prophylaxis of dyslipidemic, cardiovascular, cns, inflammatory, and other diseases/conditions or risk factors therefore..
04/17/14
20140107205
new patent Omega-3 pentaenoic acid compositions and methods of use
Orally administrable composition comprising fatty acids, wherein at least 50% by weight of the fatty acids comprise omega-3-fatty acids, salts or derivatives thereof, wherein the omega-3 fatty acids comprise eicosapentaenoic acid (epa; c20:5-n3), docosapentaenoic acid (dpa; c22:5-n3), and docosahexaenoic acid (dha; c22:6-n3), wherein the ratio of dha to epa (dha:epa) is less than 1:20, and wherein the ratio of dha to dpa (dha:dpa) is less than 2:1 are provided. These compositions can be used for the treatment or prophylaxis of dyslipidemic, cardiovascular, cns, inflammatory, and other diseases/conditions or risk factors therefore..
04/17/14
20140107202
new patent 4-[(haloalkyl)(dimethyl)ammonio]butanoates and use thereof in the treatment of cardiovascular disease
Method for preparing thereof and use thereof for treating cardiovascular disease.. .
04/17/14
20140107200
new patent Omega-3 pentaenoic acid compositions and methods of use
Orally administrable composition comprising fatty acids comprising omega-3-fatty adds, salts or derivatives thereof are provided. These compositions can be used for the treatment or prophylaxis of dyslipidemic, cardiovascular, cns, inflammatory, and other diseases/conditions or risk factors therefore..
04/17/14
20140107199
new patent Omega-3 pentaenoic acid compositions and methods of use
Orally administrable composition comprising fatty acids comprising omega-3-fatty acids, salts or derivatives thereof are provided. These compositions can be used for the treatment or prophylaxis of dyslipidemic, cardiovascular, cns, inflammatory, and other diseases/conditions or risk factors therefore..
04/17/14
20140107198
new patent Omega-3 pentaenoic acid compositions and methods of use
Orally administrable composition comprising fatty acids, wherein at least 50% by weight of the fatty acids comprise omega-3-fatty acids, salts or derivatives thereof, wherein the omega-3 fatty acids comprise eicosapentaenoic acid (epa; c20:5-n3), docosapentaenoic acid (dpa; c22:5-n3), and docosahexaenoic acid (dha; c22:6-n3), wherein the ratio of dha to epa (dha:epa) is less than 1:20, and wherein the ratio of dha to dpa (dha:dpa) is less than 2:1 are provided. These compositions can be used for the treatment or prophylaxis of dyslipidemic, cardiovascular, cns, inflammatory, and other diseases/conditions or risk factors therefore..
04/17/14
20140107191
new patent Method for enhanced uptake of viral vectors in the myocardium
The present invention relates to improved therapies for the treatment of heart disease, particularly the improved delivery of therapeutic agents to heart tissue by direct infusion into the coronary circulation. A preferred embodiment of the invention is a method of treating or preventing a cardiovascular disease by transfecting cardiac cells of a large mammal, the method comprising, identifying a mammal in need of treatment or prevention of heart disease, supplying no to the coronary circulation prior to, and/or during the infusion of a therapeutic polynucleotide into a blood vessel of the coronary circulation in vivo, where the therapeutic polynucleotide is infused into the blood vessel over a period of at least about three minutes, where the coronary circulation is not isolated or substantially isolated from the systemic circulation of the mammal; and where the therapeutic polynucleotide transfects cardiac cells of the animal resulting in the treatment or prevention of the heart disease..
04/17/14
20140107148
new patent End-capped poly(ester amide) copolymers
This invention relates to poly(ester amide)s (peas) comprising inactivated terminal amino and carboxyl groups, methods of synthesizing the inactivated peas and uses for them in the treatment of vascular diseases.. .
04/17/14
20140107062
new patent Compositions and methods for treating or preventing diseases of body passageways
The present invention provides compositions and methods for treating or preventing diseases associated with vascular and non-vascular body passageways, the method comprising the step of delivering to a body passageway a therapeutic agent delivered locally through a polymer matrix from an implanted stent or other structure.. .
04/17/14
20140107053
new patent Apples with high polyphenolic content
The invention relates to apples comprising high concentrations of polyphenols, to processes for obtaining said apples and to uses of apples as a method of treatment of prophylaxis of cardiovascular disease, colon cancer and digestive health.. .
04/17/14
20140107032
new patent Methods of treating, reducing the incidence of, and/or preventing ischemic events
Methods of treating, reducing the incidence of, and/or preventing an ischemic event in a patient undergoing percutaneous coronary intervention (pci), comprising administering to the patient a pharmaceutical composition comprising cangrelor. The method may further comprise administering an additional therapeutic agent to the patient, the additional therapeutic agent comprising bivalirudin or a p2y12 inhibitor.
04/17/14
20140107029
new patent Methods and apparatus for creating particle derivatives of hdl with reduced lipid content
The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of hdl without substantially affecting ldl. These derivatives of hdl are particles with reduced lipid content, particularly reduced cholesterol content.
04/17/14
20140107019
new patent Engineered polypeptides having enhanced duration of action
Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including oral administration. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides.
04/17/14
20140105999
new patent Oil composition, formulations comprising the oil composition, and the use thereof to reduce accumulation of visceral fat, improve glucose tolerance, and prevent or treat obesity related diseases and disorders
This invention relates to an oil composition, preferably obtained from a copepod, and the use thereof to reduce accumulation of visceral fat and counteract impairment of heart function caused by obesity inducing western diets. The oil composition of the present invention can thus be used to reduce abdominal obesity and improve glucose tolerance and thus to reduce the risk of obesity related diseases such as but not limited to type 2 diabetes or cardiovascular disease, or to prevent or treat such diseases..
04/17/14
20140105911
new patent Method of treatment of vascular complications
The present invention provides methods for the prevention or treatment of one or more vascular complication(s) in a subject at risk of developing diabetes mellitus, impaired glucose tolerance and/or hyperglycemia or a subject suffering from diabetes mellitus, impaired glucose tolerance and/or hyperglycemia, wherein an amount of a composition effective to inhibit, repress, delay or otherwise reduce expression and/or activity and/or level of txnip and/or an amount of a composition effective to induce, enhance or otherwise increase expression and/or activity and/or level of trx is/are administered to a subject in need thereof. The present invention also provides methods for identifying and isolating modulators of txnip expression and/or activity and/or level and/or trx expression and/or activity and/or level for use in such therapeutic and prophylactic methods..
04/17/14
20140105883
new patent Use of botulinum toxin for the treatment of cerebrovascular disease, renovascular and retinovascular circulatory beds
Methods of using botulinum toxin based pharmaceuticals are disclosed. The methods cause vasodilatation and decreased flow resistance of certain vascular beds for the purpose of increasing blood flow to a region in order to positively impact deterioration from a number of diseases..
04/17/14
20140105868
new patent Method for treating vascular-related disease
A method for treating a vascular-related disease in a subject in need thereof, includes administering to the subject a peptide having a sequence xaa-gly-asp. The peptide may have a sequence of seq id nos: 1, 2, 4, 6 to 10.
04/17/14
20140105867
new patent Blockage of pai-1 in diabetic cd34+ stem cells corrects cellular dysfunction
Disclosed herein are methods of enhancing repair of vascular lesions involving the administration of cells in which pai-1 expression and/or activity has been transiently blocked. Other methods involve the administration of a pai-1 blocking agent to a subject who has a vascular lesion or is at risk of developing a vascular lesion.
04/17/14
20140105821
new patent Antibody that stops or slows tumour growth (variants)
A monoclonal antibody is described herein specifically binding to domains ii and iiic of fgfr1 or to a complex of fibroblast growth factor receptor type 1 and heparan sulphate. A method is proposed for suppressing tumour growth, based on blocking the human fibroblast growth factor/human fibroblast growth factor receptor type 1 (domains ii and iiic) pathway and involves administering the antibody.
04/10/14
20140100650
Endovascular graft for aneurysms involving major branch vessels
Systems and methods for treating diseased bodily lumens involving branched lumen deployment sites include a main graft or stent-graft deployable in a main artery and a vent device or stent-graft deployable in a branch artery to maintain blood flow through the main artery and from the main artery to the branch artery. Systems and methods for treating diseased bodily lumens involving branched lumen deployment sites may also include a main graft or stent-graft deployable in the main artery, a chimney graft or stent-graft deployable in both branch artery and the main artery to the branch artery and a gutter-sealing device associated with the chimney graft to prevent flow of blood among the chimney graft, the main graft and a wall of the main artery..
04/10/14
20140100648
Multi-layer vascular prosthesis
A vascular prosthesis comprising a tubular support structure having an outer surface and an internal lumen therethrough, the support structure comprising a base material, which can comprise natural or synthetic materials, the internal lumen surface including an extracellular matrix (ecm) layer that includes at least one ecm material, wherein, when said vascular prosthesis is deployed proximate damaged cardiovascular tissue, the prosthesis induces modulated healing of the damaged tissue. In some embodiments, the support member outer surface also includes an ecm layer..
04/10/14
20140100605
Apparatus and methods for sealing a vascular puncture
Apparatus for sealing a puncture communicating with a blood vessel includes a porous carrier formed from lyophilized hydrogel or other material. The plug may include at least first and second hydrogel precursors and a ph adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment.
04/10/14
20140100598
Vascular device for emboli, thrombus and foreign body removal and methods of use
Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device comprises one or more support hoops connected near a distal end of a guide wire, each support hoop having an articulation region, and a blood permeable sac affixed to the support hoop or hoops to form a mouth of the blood permeable sac. The mouth of the sac closes when the apparatus is collapsed for removal to prevent material from escaping from the sac..
04/10/14
20140100562
Renal nerve modulation devices and methods
Systems for nerve and tissue modulation are disclosed. An example system may include an intravascular nerve modulation system including an elongated shaft having a proximal end region and a distal end region.
04/10/14
20140100552
Vascular access systems having a guidewire anti-migration feature
Disclosed herein is a removable cap for connection to an input port of a catheter, comprising a proximal end having a lumen configured to house a guidewire therethrough; a distal end configured to reversibly mate with a luer lock of the input port of a catheter, the distal end having a lumen configured to house the guidewire therethrough; and a tubular body between the proximal end and the distal end, wherein the tubular body comprises an anti-migration feature transformable between a first configuration to allow slidable movement of the guidewire within the cap in a first direction toward the patient, and a second configuration to prevent slidable movement of the guidewire within the cap in the first direction toward the patient. Systems and methods are also disclosed..
04/10/14
20140100549
Follow-up of the vascular access of a dialyzed patient
The invention relates to a calculation and control system for the determination of the state of a vascular access of a patient intended to follow successive sessions of extracorporeal blood treatment by extraction and return of the blood via the vascular access, the system comprising: means for determining the value of at least one hemodynamic extracorporeal parameter of the patient for at least two sessions; means for determining the value of the purification effectiveness of the treatment for at least two sessions; programmed means for determining a risk score relating to the state of the vascular access of the patient as a function of at least two values of the hemodynamic extracorporeal parameter and of at least two determined values of the purification effectiveness.. .
04/10/14
20140100508
Hybrid arteriovenous shunt
An apparatus for positioning a graft and catheter operable for subcutaneous access to the vascular system of a patient. A surgically created, hybrid arteriovenous shunt is provided which comprises a flexible graft and a venous outflow catheter connected to the graft via surgical anastomosis over a cuff.
04/10/14
20140100462
Polarization scrambling for intra-body fiber optic sensor
In an example, an optical system can include a polarization scrambler coupleable to a tunable first optical source configured to generate a coherent optical output. The system can include an intra-body optical sensor such as a an intravascularly-deliverable optical fiber transducer, configured to be coupled to the tunable first optical source through the polarization scrambler, the polarization scrambler configured to vary a polarization state of the optical energy provided by the tunable first optical source, the intravascularly-deliverable optical fiber transducer configured to reflect a portion of the optical energy modulated in response to a vibration, pressure, or strain.
04/10/14
20140100456
Methods for localizing implanted vascular access devices
Disclosed are vascular access devices, implantable dialysis grafts, and systems including them useful for improved access to implanted medical devices. Also disclosed are implantable hemodialysis vascular access graft devices that facilitate easy, accurate and reproducible cannulation or needle entry into the implanted device by magnetically-locating a portion of the graft that includes one or more paramagnetic materials operably defining the physical boundaries of the target cannulation site/entry port..
04/10/14
20140100443
System and method for imaging of the vascular components with temporal information and suppressed blood pools using magnetic resonance imaging
A system and method is provided that includes a) monitoring a cardiac cycle of the subject to identify a predetermined point and, b) upon identifying the predetermined point, performing the steps of i) performing at least one of a desired number of magnetization suppressing preparations to suppress signal from blood flow through at least the region of interest, ii) acquiring a first set of imaging data from the region of interest, and iii) repeating step i) and step ii) to acquire at least a second set of imaging data from the region of interest. The method further includes c) repeating step b) a predetermined number of times over a series of cardiac cycles to acquire respective sets of medical imaging data of the region of interest and d) reconstructing first set of imaging data and the second set of imaging data into a time-resolved series of images..
04/10/14
20140100411
Treatment of cardiovascular disorders with targeted nanoparticles
Methods for treating various cardiovascular disorders include targeted delivery of calcium ions for permanently impairing a portion of the autonomic nervous system (ans). Targeted delivery may be via magnetically-targetable nanoparticles..
04/10/14
20140100289
Methods and compositions for treating mammalian nerve tissue injuries
To achieve, an in vivo repair of injured mammalian nerve tissue, an effective amount of a biomembrane fusion agent is administered to the injured nerve tissue. The application of the biomembrane fusion agent may be performed by directly contacting the agent with the nerve tissue at the site of the injury.
04/10/14
20140100281
Omega-3 pentaenoic acid compositions and methods of use
Orally administrable composition comprising fatty acids, wherein at least 50% by weight of the fatty acids comprise omega-3-fatty acids, salts or derivatives thereof, wherein the omega-3 fatty acids comprise eicosapentaenoic acid (epa; c20:5-n3), docosapentaenoic acid (dpa; c22:5-n3), and docosahexaenoic acid (dha; c22:6-n3), wherein the ratio of dha to epa (dha:epa) is less than 1:20, and wherein the ratio of dha to dpa (dha:dpa) is less than 2:1 are provided. These compositions can be used for the treatment or prophylaxis of dyslipidemic, cardiovascular, cns, inflammatory, and other diseases/conditions or risk factors therefore..
04/10/14
20140100258
Methods for treating degenerative diseases/injuries
Invented is a method of treating cardiovascular disease/injury, in a mammal, including a human, in need thereof which comprises the administration of a therapeutically effective amount of a non-peptide tpo receptor agonist to such mammal.. .
04/10/14
20140100243
Substituted 4-aryl-1,4-dihydro-1,6-naphthyridine amides and their use
The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridine-3-carboxamides, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.. .
04/10/14
20140100234
Quinoline derivatives as pi3 kinase inhibitors
Invented is a method of inhibiting the activity/function of pi3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives..
04/10/14
20140100229
Fluoroalkyl-substituted pyrazolopyridines and use thereof
The present application relates to novel fluoroalkyl-substituted pyrazolopyridines, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases and to their use for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.. .
04/10/14
20140100216
Stimulators of incretin hormones secretion, method for preparation and use thereof
The invention relates to the area of medicinal chemistry, pharmacology and medicine and includes description of pharmaceutical compositions and combined medicaments on the base of secretion stimulators and protectors of incretin hormones for treatment of metabolic diseases (among them, diabetes, obesity, metabolic syndrome and the like). The invention consists in that that pharmaceutical composition or combined medicament comprises a derivative of tetrahydrobenzo[f][1,4]oxazepine—either nonsteroidal agonist of bile aids receptor tgr5, or one of endogenous bile acids which stimulate incretin hormones secretion, and also one of the known inhibitors of dpp-iv proteinase.
04/10/14
20140100191
Vesicular formulations
Disclosed herein are vesicular formulations that include one or more phospholipids and one or more surfactants and in certain embodiments the use of such formulations for the delivery of fatty acids for the treatment of disorders such as, fatty acid metabolic disorders, including essential fatty acid deficiency; pain or inflammation or osteoarthritis, more specifically for the treatment of deep tissue pain; asthma, bronchospasm, atherothrombatic cardiovascular disorders, avenous thrombatic disorders, inflammatory dermatoses disorders (e.g., atopic eczema, dishydrotic hand eczema, plaque type psoriasis, seborrheic eczema, and acne vulgaris), and dysmenorrhea.. .
04/10/14
20140100167
Assessment of cardiac health and thrombotic risk in a patient
The invention features methods and compositions for assessing risk, particularly immediate risk, of thrombotic events in patients with suspected or known vascular disease, and more particularly to assessing risk of thrombotic events in patients with coronary artery disease, particularly acute myocardial infarction, stroke, unstable angina, stable angina, or restenosis. Risk of thrombosis can be assessed by analysis of platelet reactivity and/or velocity of thrombin or fibrin formation, and determining whether the patient has a score associated above a risk threshold value.
04/10/14
20140100128
Use of markers in the identification of cardiotoxic agents and in the diagnosis and monitoring of cardiomyopathy and cardiovascular disease
The invention provides methods for the diagnosis and prognosis of cardiovascular disease, and for monitoring of the treatment of cardiovascular disease, including heart failure and cardiomyopathy. The invention further provides methods for identifying an agent for treating cardiomyopathy or heart failure, for identifying a cardiotoxic agent, and for identifying a rescue agent to reduce or prevent drug-induced toxicity, by using one or more biomarkers selelcted from the group consisting of ccdc47, hmox1, ptx3, pai1, il27, igfbp7, emmprin, cfl2, edil3, nucb1, pe d18:0-20:3/d18:1-20:2/d16:0-22:3; pe d18:0-22:5/d18:1-22:4; pe d16:1-22:6; pe p18:1-18:1/p18:0-18:2/p16:0-20:2; lpc 20:3; and pc-li-183-d18:22-22:6, or any of the other biomarkers provided herein.


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