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Vascular Diseases

Vascular Diseases-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
Roche Glycart Ag
September 14, 2017 - N°20170260265

The present invention relates to bispecific antibody against human vascular endothelial growth factor (vegf/vegf-a) and against human angiopoietin-2 (ang-2) of human igg1 or igg4 subclass with mutations i253a, h310a, and h435a, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
Extended antegrade epicardial coronary infusion of adeno-associated viral vectors for gene therapy
Celladon Corporation
September 07, 2017 - N°20170252462

The present invention relates to therapies for the treatment of cardiovascular diseases, particularly the delivery of therapeutic agents to heart tissue by direct infusion into the coronary circulation. A preferred embodiment of the invention is a method of treating or preventing a cardiovascular disease by transfecting cardiac cells of a large mammal, the method comprising, identifying an mammal in need ...
Neuroactive steroids, compositions, and uses thereof
Sage Therapeutics, Inc.
August 31, 2017 - N°20170247406

Described herein are steroids of formula (i): and pharmaceutically acceptable salts thereof; wherein r1, r2a, r2b, r3, r4, r5a, r5b, r6, and z are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, ...
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Diagnostic method for disorders using copeptin
B.r.a.h.m.s Gmbh
August 24, 2017 - N°20170242037

Disclosed herein is the use of copeptin as a diagnostic marker for the determination of the release of vasopressin, especially in connection with disorders associated with non-physiological alterations of vasopressin release from the neurohypophysis, especially for detection and early detection, diagnosing and monitoring of the course of cardiovascular diseases, renal and pulmonary diseases as well as shock, including septic shock, ...
Soluble epoxide hydrolase inhibitors and uses thereof
X-chem, Inc.
August 24, 2017 - N°20170240526

The present invention features compounds having soluble epoxide hydrolase inhibitory activity. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions, such as cardiovascular diseases, respiratory diseases, inflammation, and diabetes.
Epidithiodioxopiperazine compound or its derivatives, and the use thereof
Ewha University-industry Collaboration Foundation
August 24, 2017 - N°20170239261

The present invention relates to an epidithiodioxopiperazine derivative represented by the following chemical formula 1 or its reduced derivative; a method for preparing a compound represented by chemical formula 1 having improved intracellular permeability and mimicking the activity of 2-cys-prx in its reduced form in the cells; a pharmaceutical composition for preventing or treating vascular diseases comprising an epidithiodioxopiperazine compound or its ...
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Vascular Diseases Patent Applications
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inventor
  • 120+ full patent PDF documents of Vascular Diseases-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Cyclic polypeptides for the treatment of heart failure
Aldeyra Therapeutics, Inc.
August 17, 2017 - N°20170233443

Or an amide, an ester or a salt thereof, or a bioconjugate thereof, wherein x1, x3, x4, x7, x8, x9, x10, x11, x12 and x13 are defined herein. The polypeptides are agonist of the apj receptor. The invention also relates to a method for manufacturing the polypeptides of the invention or bioconjugates thereof, and their therapeutic uses such as treatment ...
19-nor neuroactive steroids and methods of use thereof
Aldeyra Therapeutics, Inc.
August 17, 2017 - N°20170233432

And pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, tinnitus, status epilepticus.
Aza-heteroaryl compounds as pi3k-gamma inhibitors
Aldeyra Therapeutics, Inc.
August 17, 2017 - N°20170232016

And pharmaceutically acceptable salts thereof, wherein x, y, z, a, w, r4, r5, and r6 are defined herein, that inhibit the activity of phosphoinositide 3-kinases-gamma (pi3kγ) and are useful in the treatment of diseases related to the activity of pi3kγ including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
Fluorinated benzofuranyl-pyrimidine derivatives containing a suflone group
Bayer Pharma Aktiengesellschaft
August 10, 2017 - N°20170226092

The present invention relates to fluorinated benzofuranyl-pyrimidine derivatives containing a sulfone group of general formula (i) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyperproliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful ...
Phospholipid-containing marine extracts for treatment of cardiovascular diseases
Neptune Technologies & Bioressources, Inc.
August 10, 2017 - N°20170224742

The present invention relates to a method of treatment and/or prevention of cardiovascular disease, rheumatoid arthritis, skin cancer, premenstrual syndrome, diabetes and transdermal transport enhancement. The method comprises the administration of a therapeutically effective amount of krill and/or marine oil to a patient. The present invention also relates to a composition for the treatment and/or prevention of ...
4-aryl-n-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group
Bayer Intellectual Property Gmbh
August 03, 2017 - N°20170217949

The present invention relates to 4-aryl-n-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (i) or (ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate ...
Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group
Bayer Pharma Aktiengesellschaft
August 03, 2017 - N°20170217938

The present invention relates to fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group of general formula (i) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful ...
Vascular Diseases Patent Pack
Download 120+ patent application PDFs
Vascular Diseases Patent Applications
Download 120+ Vascular Diseases-related PDFs
For professional research & prior art discovery
inventor
  • 120+ full patent PDF documents of Vascular Diseases-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Anti-pdgfr-beta antibodies and uses thereof
Regeneron Pharmaceuticals, Inc.
July 27, 2017 - N°20170210813

The present invention provides antibodies that bind to platelet derived growth factor receptor beta (pdgfr-beta) and methods of using the same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human pdgfr-beta with high affinity. The antibodies of the invention are useful for the treatment of diseases and disorders associated with pdgfr-beta signaling ...
Aplnr modulators and uses thereof
Regeneron Pharmaceuticals, Inc
July 27, 2017 - N°20170210800

The present invention provides apelin receptor (aplnr) modulators that bind to aplnr and methods of using the same. The invention includes aplnr modulators such as antibodies, or antigen-binding fragments thereof, which inhibit or attenuate aplnr-mediated signaling. The invention includes aplnr modulators such as antibodies, or antibody fusion proteins thereof, that activate aplnr-mediated signaling. According to certain embodiments of the invention, ...
A peptide therapy to counteract insulin resistance and type 2 diabetes
Indian Institute Of Technology Madras
July 27, 2017 - N°20170209544

Compositions comprising an antagonist of pancreastatin are provided. The beneficial use of the compositions for treating insulin resistance, diabetes, especially type ii diabetes, inflammation, obesity, non-alcoholic fatty liver disease, atherosclerosis and cardiovascular diseases is described as well.
Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
The John Hopkins University
July 27, 2017 - N°20170209435

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases ...
5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group
Bayer Pharma Aktiengesellschaft
July 20, 2017 - N°20170202815

The present invention relates to 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group of general formula (i) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to ...
Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
The John Hopkins University
July 13, 2017 - N°20170198253

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases ...
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme Corp.
July 13, 2017 - N°20170197989

The present invention provides compounds of formula (i) and the pharmaceutically acceptable salts thereof, which are inhibitors of the romk (kir1. 1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt ...
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme Corp.
July 13, 2017 - N°20170197964

The present invention provides compounds of formula i and the pharmaceutically acceptable salts thereof, which are inhibitors of the romk (kir1. 1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt ...
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