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Vascular Diseases

Vascular Diseases-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Amide-substituted pyridinyltriazole derivatives and uses thereof
Bayer Pharma Aktiengesellschaft
November 09, 2017 - N°20170320854

The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
Preparation containing chlorogenic acid crystal form and use thereof
Sichuan Jiuzhang Biological Science And Technology Co., Ltd.
November 09, 2017 - N°20170319530

A preparation containing a chlorogenic acid crystal form. The crystal form is an orthorhombic crystal system, a space group is p212121, cell parameters are as follows: a=7. 7291(2)Å, b=10. 9808(2)Å, c=36. 5334(7)Å, α=β=γ=90. 00°, z=8, and a cell volume is 3100. 65(11)Å3. The content of the chlorogenic acid crystal form in the ...
Method for the synthesis of hydroxy-triglycerides and uses thereof for the prevention and treament of ...
Sichuan Jiuzhang Biological Science And Technology Co., Ltd.
November 02, 2017 - N°20170313646

The present invention relates to hydroxy-triglycerides, their synthesis, a pharmaceutical and/or nutraceutical composition which comprises at least one of said hydroxy-triglycerides, and a method which comprises the administration to a patient of a therapeutically effective quantity of at least one of said hydroxy-triglycerides or at least one of said pharmaceutical and/or nutraceutical compositions, for the prevention and/or ...
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Modified pigment epithelium-derived factor (pedf) peptides and uses thereof for treating neovascular diseases, inflammatory diseases, ...
Northwestern University
October 26, 2017 - N°20170305998

Disclosed are modified pigment epithelium-derived factor (pedf) peptides, particulate carrier prodrugs thereof, and pharmaceutical compositions comprising the peptides or particulate carrier prodrugs. The peptides, particulate carrier prodrugs, and pharmaceutical compositions may be used to treat diseases and disorders that are amenable to treatment with anti-angiogenic agents, anti-tumorigenic agents, anti-fibrotic agents, chemotherapy-protecting agents, and immune stimulating agents
Anti-endothelial lipase compounds and methods of using the same in the treatment and/or prevention ...
Shifa Biomedical Corporation
October 26, 2017 - N°20170305887

Endothelial lipase (el) inhibitors and methods of using such inhibitors for treating conditions implicating el are provided herein. The present invention meets the needs in the field by providing small molecule inhibitors of el function that can be used therapeutically to raise hdl cholesterol levels in blood, and can be used in the prevention and/or treatment of cholesterol and ...
Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
Salk Institute For Biological Studies
October 26, 2017 - N°20170304255

Provided herein are compounds of formula (i) useful for the treatment of ppar-delta related diseases (e. G. Mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases).
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Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin
Salk Institute For Biological Studies
October 19, 2017 - N°20170296506

The present application provides methods for treating cardiovascular conditions. The methods can include administering a transient receptor potential vanilloid 1 (trpv1) receptor agonist to an epidural space. The methods can be used to treat a variety of conditions such as hypertension, prehypertension, mild hypertension, severe hypertension, refractory hypertension, congestive heart failure and myocardial scarring.
Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof
University Of Texas Board Of Regents
October 12, 2017 - N°20170292159

The present invention provides compositions and methods based on genetic polymorphisms that are associated with cardiovascular diseases, particularly coronary heart disease (especially myocardial infarction) or hypertension. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods ...
Methods for treating hyperlipidemia with an angptl8 inhibitor and an angptl3 inhibitor
Regeneron Pharmaceuticals, Inc.
October 12, 2017 - N°20170291937

The present invention provides methods for treating patients suffering from hyperlipidaemia, wherein the patient is non-responsive to, inadequately controlled by, or intolerant to treatment with a standard lipid modifying therapy. The methods of the invention provide for lowering at least one lipid parameter in the patient by administering a therapeutically effective amount of an antibody or antigen-binding fragment thereof that ...
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme Corp.
October 05, 2017 - N°20170283416

The present invention provides compounds of formula i and the pharmaceutically acceptable salts thereof, which are inhibitors of the romk (kir1. 1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt ...
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme Corp.
September 28, 2017 - N°20170275302

The present invention provides compounds of formula (i) and the pharmaceutically acceptable salts thereof, which are inhibitors of the romk (kir1. 1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt ...
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme Corp.
September 28, 2017 - N°20170275298

The present invention provides compounds of formula i and the pharmaceutically acceptable salts thereof, which are inhibitors of the romk (kir1. 1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt ...
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme Corp.
September 28, 2017 - N°20170275292

The present invention provides compounds of formula i: (i) and the pharmaceutically acceptable salts thereof, which are inhibitors of the romk (kir1. 1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive ...
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Vascular Diseases Patent Applications
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  • 120+ full patent PDF documents of Vascular Diseases-related inventions.
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Therapeutic and research application of pdcl3
Trustees Of Boston University
September 28, 2017 - N°20170274075

Described herein are novel compositions comprising, for example, pdcl3 polypeptides having vegfr-2 inhibitory activity, inhibitory pdcl3 antibodies and pdcl3-binding fragments thereof, or pdcl3 inhibitory nucleic acid molecules, and methods of their use in anti-angiogenesis and anti-tumor proliferation and invasiveness therapies, such as the treatment of cancer, as well as the treatment of those vascular diseases where pathological angiogenesis plays ...
A novel synergistic herbal formulation for degenerative disease cardiovascular diseases, autoimmune, inflammatory and metabolism disorder ...
Trustees Of Boston University
September 21, 2017 - N°20170266247

The present invention relates to a novel synergistic herbal formulation for degenerative disease, cardiovascular diseases, autoimmune, inflammatory and infectious diseases and metabolism disorder etc. Of man, animal and plants more particularly, the present invention relates to the herbal formulation for degenerative disease, cardiovascular diseases, autoimmune, inflammatory and infectious diseases etc which is prepared by using preparation of pongamia pinnata, dalbergia ...
Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
Roche Glycart Ag
September 14, 2017 - N°20170260265

The present invention relates to bispecific antibody against human vascular endothelial growth factor (vegf/vegf-a) and against human angiopoietin-2 (ang-2) of human igg1 or igg4 subclass with mutations i253a, h310a, and h435a, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
Extended antegrade epicardial coronary infusion of adeno-associated viral vectors for gene therapy
Celladon Corporation
September 07, 2017 - N°20170252462

The present invention relates to therapies for the treatment of cardiovascular diseases, particularly the delivery of therapeutic agents to heart tissue by direct infusion into the coronary circulation. A preferred embodiment of the invention is a method of treating or preventing a cardiovascular disease by transfecting cardiac cells of a large mammal, the method comprising, identifying an mammal in need ...
Neuroactive steroids, compositions, and uses thereof
Sage Therapeutics, Inc.
August 31, 2017 - N°20170247406

Described herein are steroids of formula (i): and pharmaceutically acceptable salts thereof; wherein r1, r2a, r2b, r3, r4, r5a, r5b, r6, and z are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, ...
19-nor c3, 3-disubstituted c21-n-pyrazolyl steroids and methods of use thereof
Sage Therapeutics, Inc.
August 31, 2017 - N°20170246191

And pharmaceutically acceptable salts thereof; wherein , r1, r2, r3a, r3b, r4a, r4b, r5, r6, and r7 are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement ...
Diagnostic method for disorders using copeptin
B.r.a.h.m.s Gmbh
August 24, 2017 - N°20170242037

Disclosed herein is the use of copeptin as a diagnostic marker for the determination of the release of vasopressin, especially in connection with disorders associated with non-physiological alterations of vasopressin release from the neurohypophysis, especially for detection and early detection, diagnosing and monitoring of the course of cardiovascular diseases, renal and pulmonary diseases as well as shock, including septic shock, ...
Soluble epoxide hydrolase inhibitors and uses thereof
X-chem, Inc.
August 24, 2017 - N°20170240526

The present invention features compounds having soluble epoxide hydrolase inhibitory activity. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions, such as cardiovascular diseases, respiratory diseases, inflammation, and diabetes.
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