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Vascular Disease

Vascular Disease-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof
University Of Texas Board Of Regents
October 12, 2017 - N°20170292159

The present invention provides compositions and methods based on genetic polymorphisms that are associated with cardiovascular diseases, particularly coronary heart disease (especially myocardial infarction) or hypertension. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods ...
Methods for treating hyperlipidemia with an angptl8 inhibitor and an angptl3 inhibitor
Regeneron Pharmaceuticals, Inc.
October 12, 2017 - N°20170291937

The present invention provides methods for treating patients suffering from hyperlipidaemia, wherein the patient is non-responsive to, inadequately controlled by, or intolerant to treatment with a standard lipid modifying therapy. The methods of the invention provide for lowering at least one lipid parameter in the patient by administering a therapeutically effective amount of an antibody or antigen-binding fragment thereof that ...
Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with serm
Endorecherche, Inc.
October 12, 2017 - N°20170290847

Novel methods for prevention, reduction or elimination of the incidence of male androgen deficiency symptoms or diseases including male hypogonadism-associated symptoms and diseases associated with low serum testosterone and/or low dhea or low total androgens in susceptible warm-blooded animals including humans involving administration of an amount of a sex steroid precursor, particularly dehydroepiandrosterone (dhea) and a selective estrogen receptor ...
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Vascular Disease Patent Applications
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Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme Corp.
October 05, 2017 - N°20170283416

The present invention provides compounds of formula i and the pharmaceutically acceptable salts thereof, which are inhibitors of the romk (kir1. 1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt ...
Chelator-targeting ligand conjugates for cardiovascular imaging
Cell>point, Llc
October 05, 2017 - N°20170281806

Disclosed are methods of imaging a site in a heart of a subject to detect cardiovascular disease that involve stressing a subject, administering to the stressed subject an effective amount of a radionuclide-labeled chelator-glucose analog conjugate, and imaging the heart of the subject by detecting a signal generated by the conjugate in the heart of the subject. Also disclosed are ...
Composition for preventing or treating peripheral vascular disease using hepatocyte growth factor and stromal cell ...
Viromed Co., Ltd.
October 05, 2017 - N°20170281729

The present invention relates to a pharmaceutical composition for preventing or treating peripheral vascular disease, the composition comprising, as an active ingredient: (a) hepatocyte growth factor (hgf) or an isoform thereof, and stromal cell derived factor 1α (sdf-1α); or (b) a polynucleotide encoding the hgf and a polynucleotide encoding the sdf-1α. The peripheral vascular disease (...
Vascular Disease Patent Pack
Download 215+ patent application PDFs
Vascular Disease Patent Applications
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For professional research & prior art discovery
inventor
  • 215+ full patent PDF documents of Vascular Disease-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme Corp.
September 28, 2017 - N°20170275302

The present invention provides compounds of formula (i) and the pharmaceutically acceptable salts thereof, which are inhibitors of the romk (kir1. 1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt ...
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme Corp.
September 28, 2017 - N°20170275298

The present invention provides compounds of formula i and the pharmaceutically acceptable salts thereof, which are inhibitors of the romk (kir1. 1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt ...
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme Corp.
September 28, 2017 - N°20170275292

The present invention provides compounds of formula i: (i) and the pharmaceutically acceptable salts thereof, which are inhibitors of the romk (kir1. 1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive ...
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme Corp.
September 28, 2017 - N°20170275283

The present invention provides compounds of formula i and the pharmaceutically acceptable salts thereof, which are inhibitors of the romk (kir1. 1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt ...
Therapeutic and research application of pdcl3
Trustees Of Boston University
September 28, 2017 - N°20170274075

Described herein are novel compositions comprising, for example, pdcl3 polypeptides having vegfr-2 inhibitory activity, inhibitory pdcl3 antibodies and pdcl3-binding fragments thereof, or pdcl3 inhibitory nucleic acid molecules, and methods of their use in anti-angiogenesis and anti-tumor proliferation and invasiveness therapies, such as the treatment of cancer, as well as the treatment of those vascular diseases where pathological angiogenesis plays ...
Cardiovascular disease primary prevention agent for patients having high blood levels of high-sensitivity c-reactive protein
Kyushu University, National University Corporation
September 28, 2017 - N°20170273929

The present invention provides the following: a cardiovascular disease primary prevention agent, which comprises as the active ingredient at least one selected from the group consisting of epa, salts thereof, and esters thereof and is for lowering the risk of cardiovascular disease by administration to subjects having a blood (serum or plasma) hs-crp level of 1. 0 mg/l or higher in ...
Modulation of apolipoprotein ciii (apociii) expression
Ionis Pharmaceuticals, Inc.
September 21, 2017 - N°20170268004

Provided herein are methods, compounds, and compositions for reducing expression of apociii mrna and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing hdl levels and/or improving the ratio of tg to hdl and reducing plasma lipids and plasma glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, ...
Vascular Disease Patent Pack
Download 215+ patent application PDFs
Vascular Disease Patent Applications
Download 215+ Vascular Disease-related PDFs
For professional research & prior art discovery
inventor
  • 215+ full patent PDF documents of Vascular Disease-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
A novel synergistic herbal formulation for degenerative disease cardiovascular diseases, autoimmune, inflammatory and metabolism disorder ...
Mega Sun Biomedical Corp.
September 21, 2017 - N°20170266247

The present invention relates to a novel synergistic herbal formulation for degenerative disease, cardiovascular diseases, autoimmune, inflammatory and infectious diseases and metabolism disorder etc. Of man, animal and plants more particularly, the present invention relates to the herbal formulation for degenerative disease, cardiovascular diseases, autoimmune, inflammatory and infectious diseases etc which is prepared by using preparation of pongamia pinnata, dalbergia ...
Treating and preventing disease with tma and tmao lowering agents
The Cleveland Clinic Foundation
September 21, 2017 - N°20170266208

Provided herein are compositions, systems, and methods for treating a disease, such as kidney and/or cardiovascular disease, with an agent that reduces the production of trimethylamine (tma) or trimethylamine-n-oxide (tmao) in a subject. In certain embodiments, the agent is: i) 3,3-dimethyl-1-butanol (dmb) or a dmb derivative or related compound, ii) acetylsalicylic acid or derivative thereof (e. G., with ...
Method for characterisation of perivascular tissue
Oxford University Innovation Limited
September 21, 2017 - N°20170265832

Methods for volumetric characterisation of perivascular adipose tissue use data collected by computed tomography (ct) scanning. The volumetric characterisation of perivascular adipose tissue allows the inflammatory status of underlying blood vessels to be established by ct scanning. This is of use in the diagnosis, prognosis and treatment of coronary and vascular disease.
Markers associated with arteriovascular events and methods of use thereof
True Health Ip Llc
September 14, 2017 - N°20170261520

Disclosed are methods of identifying subjects with arteriovascular disease, subjects at risk for developing arteriovascular disease, methods of differentially diagnosing diseases associated with arteriovascular disease from other diseases or within sub-classifications of arteriovascular disease, methods of evaluating the risk of arteriovascular events in patients with arteriovascular disease, methods of evaluating the effectiveness of treatments in subjects with arteriovascular disease, and ...
Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
Roche Glycart Ag
September 14, 2017 - N°20170260265

The present invention relates to bispecific antibody against human vascular endothelial growth factor (vegf/vegf-a) and against human angiopoietin-2 (ang-2) of human igg1 or igg4 subclass with mutations i253a, h310a, and h435a, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
Indole carboxamide compounds
Roche Glycart Ag
September 14, 2017 - N°20170260160

Or a salt thereof, wherein: x is cr4 or n; r1, r2, r3, r4, and a are defined herein. Also disclosed are methods of using such compounds as inhibitors of bruton's tyrosine kinase (btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic ...
Treatment and prevention of cardiovascular disease and thrombosis
The Cleveland Clinic Foundation
September 14, 2017 - N°20170258740

Provided herein are compositions for the treatment and/or prevention of cardiovascular disease (cvd), and methods of application and use thereof. In particular, the present invention provides treatment and/or prevention of cardiovascular disease with compounds that inhibit the production of tma in the gut, such as 3,3-dimethyl-1-butanol (dmb) or other compounds represented by formula i or as shown ...
Methods for treating patients with hyperlipidemia by administering a pcsk9 inhibitor in combination with an ...
Regeneron Pharmaceuticals, Inc.
September 07, 2017 - N°20170253666

The present invention provides methods for treating patients suffering from hypercholesterolemia, wherein the patient is non-responsive to, inadequately controlled by, or intolerant to treatment with a standard lipid modifying therapy. The methods of the invention provide for lowering at least one lipid parameter in the patient by administering a therapeutically effective amount of an antibody or antigen-binding fragment thereof that ...
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