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Vascular Disease

Vascular Disease-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme Corp.
January 18, 2018 - N°20180016263

The present invention provides compounds of formula (i); and the pharmaceutically acceptable salts thereof, which are inhibitors of the romk (kir1. 1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt ...
NEW Early hyperlipidemia promotes endothelial activation via a caspase-1-sirtuin 1 pathway
Temple University-of The Commonwealth System Of Higher Education
January 18, 2018 - N°20180015152

The present invention provides compositions and methods for treating or preventing a disease or disorder associated with endothelial activation, inflammation or atherogenesis, including but not limited to cardiovascular diseases and inflammatory disorders.
NEW Treatment of retinal vascular disease using progenitor cells
Janssen Biotech, Inc.
January 18, 2018 - N°20180015129

Methods and compositions for treating ophthalmic disease, reducing retinal neovascularization and retinal vascular leakage using progenitor cells, such as postpartum-derived cells, and conditioned media from the cells, are disclosed.
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Vascular Disease Patent Applications
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Lpl/rlp for assessment of cardiovascular disease risk
True Health Diagnostics, Llc
January 11, 2018 - N°20180011094

In various embodiments, the application relates to methods for assessment of cardiovascular disease (cvd) risk in a patient comprising comparing pre-heparin lpl (lipoprotein lipase) levels which are associated with protection from cvd to remnant lipoprotein cholesterol (rlp-c) and/or remnant lipoprotein triglyceride content (rlp-tg).
Systemic delivery and regulated expression of paracrine genes for cardiovascular diseases and other conditions
The Regents Of The University Of California
January 11, 2018 - N°20180010148

In alternative embodiments, the invention provides methods for treating, ameliorating or protecting (preventing) an individual or a patient against a disease, an infection or a condition responsive to an increased paracrine polypeptide level in vivo comprising: providing a paracrine polypeptide-encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence; or an expression vehicle, a vector, a recombinant virus, ...
Method of enhancing mir-185 expression to reduce low density lipoprotein/cholesterol accumulation in a cell
Medical Diagnostic Laboratories, Llc
January 11, 2018 - N°20180010127

The present invention provides a method of quantifying mir-185 as a potential biomarker in lipid disorder or cardiovascular diseases in human. The present invention also provides a method of modulating mir-185 in regulating ldl and cholesterol metabolism in cells. The present invention has therapeutic potential in the treatment of cholesterol/ldl related cardiovascular diseases in humans.
Vascular Disease Patent Pack
Download 215+ patent application PDFs
Vascular Disease Patent Applications
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inventor
  • 215+ full patent PDF documents of Vascular Disease-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Heterocyclic compounds as pi3k-y inhibitors
January 11, 2018 - N°20180009816

Or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of pi3k-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme Corp.
January 11, 2018 - N°20180009807

The present invention provides compounds of formula i (i) and the pharmaceutically acceptable salts thereof, which are inhibitors of the romk (kir1. 1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive ...
Multi-tyrosine kinase inhibitors derivatives and methods of use
Ontogenesis, Llc
January 11, 2018 - N°20180009758

The present invention is directed to multi-tyrosine kinase inhibitor compounds. The present invention is further directed to compositions comprising those compounds. Finally, the present invention is directed to methods of treating eye conditions including, but not limited to, diabetic background retinopathy, diabetic macular edema, diabetic proliferative retinopathy, diabetic macular edema with proliferative retinopathy, proliferative fibrovascular disease, diabetic macular edema with ...
Tetrahydroquinoline derivatives and their use as epac inhibitors
Universite D'orleans
January 11, 2018 - N°20180009757

The invention relates to tetrahydroquinoline derivatives and their use in the treatment and/or the prevention of a disease wherein the epac protein is involved, such as inflammation, cancer, vascular diseases, kidney diseases, cognitive disorders and cardiac diseases.
Health care
January 11, 2018 - N°20180008618

The treatment of type 2 diabetes involving the use of a regimen comprising: (a) one or more glucose-lowering drugs (g-lds) which function to lower the amount of glucose in the blood, preferably glyburide and metformin; (b) at least one non-steroidal anti-inflammatory drug (nsaid) selected from the group consisting of (1) magnesium salicylate tetrahydrate (hereafter “mg salicylate”); (2) naproxen; and (3) ...
Prosthesis having pivoting fenestration
Cook Medical Technologies Llc
January 11, 2018 - N°20180008397

The present disclosure relates to an endoluminal prosthesis, such as a stent graft that includes one or more fenestrations to accommodate endovascular disease, such as an aneurysm in cases where one or more side branches is involved. In one aspect, the prosthesis includes fenestrations that are pivotable to accommodate the dynamic geometry of the aortic branches.
Method of treating or ameliorating type 1 diabetes using fgf21
Amgen Inc.
January 04, 2018 - N°20180000898

Methods of treating metabolic diseases and disorders using a fgf21 polypeptide are provided. In various embodiments the metabolic disease or disorder is type 1 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels, diabetic nephropathy, neuropathy, retinopathy, ischemic heart disease, peripheral vascular disease and cerebrovascular disease
Vascular Disease Patent Pack
Download 215+ patent application PDFs
Vascular Disease Patent Applications
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For professional research & prior art discovery
inventor
  • 215+ full patent PDF documents of Vascular Disease-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Pharmaceutical composition and therapeutic combination comprising a cholesteryl ester transfer protein inhibitor and hmg coa ...
Dezima Pharma B.v.
January 04, 2018 - N°20180000818

The present invention relates to a pharmaceutical composition and a therapeutic combination comprising a novel cholesteryl ester transfer protein (cetp) inhibitor and a hmg coa reductase inhibitor, which may be used in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia.
Compositions and methods for treating cardiovascular diseases
Infirst Healthcare Limited
January 04, 2018 - N°20180000763

The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a cardiovascular disease in an individual using such pharmaceutical compositions.
Method and system for vascular disease detection using recurrent neural networks
Siemens Healthcare Gmbh
December 28, 2017 - N°20170372475

A method and apparatus for vascular disease detection and characterization using a recurrent neural network (rnn) is disclosed. A plurality of 2d cross-section image patches are extracted from a 3d computed tomography angiography (cta) image, each extracted at a respective sampling point along a vessel centerline of a vessel of interest in the 3d cta image. Vascular abnormalities in the ...
Cyclodextrin-based polymers for therapeutic delivery
Cerulean Pharma Inc.
December 28, 2017 - N°20170368194

Provided are methods relating to the use of cdp-therapeutic agent conjugates for the treatment of a disease or disorder, e. G., autoimmune disease, inflammatory disease, central nervous system disorder, cardiovascular disease, or metabolic disorder. Also provided are cdp-therapeutic agent conjugates, particles comprising cdp-therapeutic agent conjugates, and compositions comprising cdp-therapeutic agent conjugates.
Diagnostics and therapeutics for diseases associated with g-protein coupled receptor adipor2 (adipor2)
Siemens Healthcare Diagnostics Inc.
December 28, 2017 - N°20170368171

The invention provides human adipor2 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. The ...
Crystal forms of scutellarin aglycone and preparation thereof
Hlk Pharmaceuticals Co., Ltd.
December 28, 2017 - N°20170368019

The invention belongs to the field of medicine and chemical industry, and particularly relates to multiple crystal forms of scutellarin aglycone and preparation thereof. The invention also relates to use of said crystal forms of scutellarin aglycone in the manufacture of a medicament for preventing and/or treating a cardiovascular or cerebrovascular disease, rheumatic arthritis or stroke sequelae, etc. The ...
Biomarker for diagnosing vascular diseases and the uses thereof
Wonmedical Corp.
December 21, 2017 - N°20170363640

Provided are a composition for diagnosing vascular disease including an agent measuring a level of interleukin 12 receptor β2 protein in the blood, and a kit for diagnosing vascular disease including the same. Further, provided is a method for diagnosing vascular disease, the method including the step of measuring a level of interleukin 12 receptor β2 protein in a blood ...
Adenylyl cyclase inhibitors, pharmaceutical compositions and method of use thereof
December 21, 2017 - N°20170362235

Wherein x, l, r1, r2, r5 are those defined herein. Compounds of the present invention are useful to treat cardiovascular diseases. The present invention also relates to a method of preventing heart failure by administering an effective amount of compound according to the invention following vascular injury and reperfusion therapy.
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