This page is updated frequently with new Vascular Disease-related patent applications.
|Venous insufficiency treatment method|
The method of treating varicose veins and other vascular diseases provides sclerosant fluid through a catheter into the body vessel to be treated. The catheter has a lumen and a plurality of sidewall exits.
|Activation of amp-protein activated kinase by oxaloacetate compounds|
The present invention relates to oxaloacetate compounds that activate amp-activated protein kinase (ampk), including the preparation of the compounds, compositions containing the compounds, preserving said compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, obesity, cardiovascular disease, alzheimer's disease, and cancer.. .
|Indolin-2-one or pyrrolo-pyridin-2-one derivatives|
The compounds may be used in the treatment of cns diseases related to positive (psychosis) and negative symptoms of schizophrenia, substance abuse, alcohol and drug addiction, obsessive-compulsive disorders, cognitive impairment, bipolar disorders, mood disorders, major depression, treatment resistant depression, anxiety disorders, alzheimer's disease, autism, parkinson's disease, chronic pain, borderline personality disorder, neurodegenerative disease, sleep disturbances, chronic fatigue syndrome, stiffness, inflammatory disease, asthma, huntington's disease, adhd, amyotrophic lateral sclerosis, epilepsy, effects in arthritis, autoimmune disease, viral and fungal infections, cardiovascular diseases, ophthalmology and inflammatory retinal diseases and balance problems.. .
|Composition comprising bio compound for treating cardiovascular disease|
A pharmaceutical composition and a method for preventing or treating a cardiovascular disease are provided. The pharmaceutical composition includes a bio compound ((2′z,3′e)-6-bromoindirubin-3′-oxime) or a pharmaceutically acceptable salt thereof as an active ingredient.
Chonnam National University Hospital
|Ultra-low fractional area coverage flow diverter for treating aneurysms and vascular diseases|
The various embodiments described herein include methods for fabricating thin- film flow diversion apparatuses. In one aspect, a method includes: (1) creating a plurality of trenches using photolithography and deep reactive ion etching on a substrate; (2) depositing a metal sacrificial layer on the substrate; (3) forming a nitinol layer with a plurality of fenestrations by depositing nitinol on the metal sacrificial layer; (4) forming a thin-film of nitinol by removing the metal sacrificial layer; (5) crystallizing the thin-film of nitinol; and (6) elongating the thin-film of nitinol..
The Regents Of The University Of California
|System and diagnosis and assessment of cardiovascular disease by comparing arterial supply capacity to end-organ demand|
Systems and methods are disclosed for to determining a blood supply and blood demand. One method includes receiving a patient-specific model of vessel geometry of at least a portion of a coronary artery, wherein the model is based on patient-specific image data of at least a portion of a patient's heart having myocardium; determining a coronary blood supply based on the patient-specific model; determining at least a portion of the myocardium corresponding to the coronary artery; determining a myocardial blood demand based on either a mass or a volume of the portion of the myocardium, or based on perfusion imaging of the portion of the myocardium; and determining a relationship between the coronary blood supply and the myocardial blood demand..
Antigen binding proteins that interact with asgr, asgr-1 and/or asgr-2 are described as well as methods of making and using such antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of asgr, asgr-1 and/or asgr-2 antigen binding proteins.
|Pharmaceutical composition for anti-vascular diseases and anti-tumor and use thereof|
An anti-vascular diseases and antitumor pharmaceutical composition is provided in the present invention, and it includes effective ingredients including bleomycin antitumor antibiotic, adrenal glucocorticoid, epinephrine or pharmaceutically acceptable salts thereof in a weight ratio of (1-8):(2-5):(0.00005-0.001). The pharmaceutical composition provided can be used for treatment of vascular diseases and tumors..
Sun Yat-sen University
|Compositions and methods for the treatment of atherosclerotic cardiovascular diseases with pde4 modulators|
Provided herein are methods of treating, preventing or managing atherosclerosis by administering a pde4 modulator. Pharmaceutical compositions, dosage forms, and kits suitable for use in methods are also provided..
|Methods and compositions for reversing disruption of the glycocalyx, inflammation, and oxidative damage|
A composition for treating multiple disease causes including a glycocalyx restoring and maintaining compound in an oral dosage form. A method of treating cardiovascular disease (cvd), by administering a glycocalyx restoring and maintaining compound to an individual suffering from cvd, restoring the glycocalyx, reversing inflammation, and reversing oxidative damage..
Insulin sensitisers and methods of treatment
The present invention relates generally to the field of therapy. The invention particularly relates to insulin sensitisers and methods of regulating glucose homeostasis and to the therapeutic or prophylactic treatment of diseases and associated conditions, in which impaired glucose uptake due to insulin resistance is involved or implicated, such as diabetes, syndrome x, hyperglycaemia, vascular disease and kidney disease.
Naia Metabolic, Inc.
In which w, x and y have the meanings indicated in claim 1, are inhibitors of tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.. .
Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents.
Aerie Pharmaceuticals, Inc.
Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses
The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, alzheimer's disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, syndrome x, thrombotic disorder. Compounds and methods of the invention can also be used to modulate c reactive protein or enhance bile production in a patient.
Esperion Therapeutics, Inc.
Bioengineered allogeneic valve
The present disclosure relates to methods for recellularization of valves in valve-bearing veins. This method is useful for producing an allogeneic venous valve, wherein a donor valve-bearing vein is decellularized and then recelluiarized using whole blood or bone marrow stem cells.
Indole carboxamide compounds
Or a salt thereof, wherein: x is cr4 or n; r1, r2, r3, r4, and a are defined herein. Also disclosed are methods of using such compounds as inhibitors of bruton's tyrosine kinase (btk), and pharmaceutical compositions comprising such compounds.
Method and system for acquiring data for assessment of cardiovascular disease
A method and system for acquiring data for assessment of cardiovascular disease, the method comprising one or more of: manipulating one or more hardware aspects of the photoplethysmography data acquisition system(s) implementing the method; manipulating or providing user experience/user interface (ux/ui) aspects of the system(s) implementing the method; acquiring, processing, and deriving insights population specific data; accounting for or controlling sampling site variability; and using other suitable sources of data in order to generate high quality data for characterization, assessment, and management of cardiovascular disease.. .
Vital Labs, Inc.
High throughput biochemical fluorometric measuring hdl redox activity
In various embodiments, a new, robust fluorometric cell-free biochemical assay that measures hdl redox activity (hra) is provided. In certain embodiments the assay is based on the oxidation of the fluorochrome amplex® red in the presence of hrp.
The Regents Of The University Of California
Aplnr modulators and uses thereof
The present invention provides apelin receptor (aplnr) modulators that bind to aplnr and methods of using the same. The invention includes aplnr modulators such as antibodies, or antigen-binding fragments thereof, that inhibit or attenuate aplnr-mediated signaling.
Regeneron Pharmaceuticals, Inc.
Enantiomers of the n-(2-amino-5-fluoro-2-methylpentyl)-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxamide, as well as of the di- and trifluoro derivatives for the treatment of cardiovascular diseases
The present application relates to novel 6-hydrogen-substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.. .
Bayer Pharma Aktiengesellschaft
Imidazo[1,2-a]pyridines as stimulators of soluble guanylate cyclase for treating cardiovascular diseases
The present application relates to novel heterocyclyl- and heteroaryl-substituted imidazo[1,2-a]pyridines, to processes for preparation thereof, to the use thereof, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.. .
Bayer Pharma Aktiengesellschaft
Imidazo[1,2-a]pyridines as soluble guanylate cyclase stimulators for the treatment of cardiovascular diseases
The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.. .
Bayer Pharma Aktiengesellschaft
Process for the synthesis of dabigatran etexilate and its intermediates
The present invention describes an improved process for the preparation of dabigatran etexilate (formula-vii) or it's pharmaceutically acceptable salt for the treatment of thrombosis, cardiovascular diseases etc. And intermediates involved in the synthesis..
Biophore India Pharmaceuticals Pvt. Ltd.
Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as hno donors
The disclosed subject matter provides certain n-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or development of a disease or condition.
The Johns Hopkins University
Vascular Disease topics:
Peripheral Vascular Disease
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