This page is updated frequently with new Vaccine-related patent applications.
|Portable refrigeration apparatus|
The present application is related to a portable refrigeration apparatus for vaccines, food items, beverage containers, or any other item. The apparatus includes a refrigerated container comprised of a plurality of substantially identical chilling panels interconnected to form a sealed container that defines an internal volume, each of the chilling panels containing a cooling element.
The Sure Chill Company Limited
|Tumor associated vaccines and compositions for disrupting tumor-derived immunosuppression for use in combination cancer immunotherapy|
In one embodiment, a single modality cancer immunotherapy regimen that includes a therapeutic composition is provided. Such a therapeutic composition may include a salmonella strain comprising a plasmid that expresses an shrna molecule that suppresses the expression of an immunosuppressive target and suppresses tumor growth.
City Of Hope
|Expression of chimeric ksac protein and producing soluble proteins by high pressure|
The present invention encompasses vaccines or compositions comprising the chimeric ksac protein that possesses immunogenic and protective properties, and methods of use including administering to an animal the antigenic ksac protein thereof to protect animals. The invention also encompasses methods for making and producing the soluble, disaggregated, refolded or active proteins from inclusion bodies produced from prokaryotes or eukaryotes..
Wherein r1 is n-c4-6alkyl or c1-2alkoxyc1-2alkyl-; r2 is hydrogen or methyl; each r3 is hydroxy, halo or n-c1-3alkyl; m is an integer having a value of 2 to 4; n is an integer having a value of 0 to 3; and p is an integer having a value of 0 to 2, are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions, for example allergic rhinitis and asthma, infectious diseases and cancer, and may also be useful as vaccine adjuvants..
|Porcine epidemic diarrhea virus vaccines and methods of use thereof|
The present disclosure provides an isolated or purified porcine epidemic diarrhea virus (pedv) or porcine epidemic diarrhea virus (pedv) s1 protein, and methods of use thereof.. .
Regents Of The University Of Minnesota
|Paramyxovirus immunogens and related materials and methods|
Described herein are methyltransferase (mtase)-defective recombinant viruses as vaccines for human metapneumovirus (hmpv), human respiratory syncytial virus (hrsv), and human parainfluenza virus type 3 (piv3); as well as related materials and methods.. .
Ohio State Innovation Foundation
|Modified adenoviruses for cancer vaccines development|
The present invention relates to adenoviral vectors, wherein the viral capsid has been coated with polypeptides, which are capable of stimulating a peptide-specific immune response in a subject and uses thereof. Furthermore, the present invention relates to methods of treating diseases, e.g.
|Purification of secreted polysaccharides from s. agalactiae|
The invention relates to bacterial mutants, particularly from streptococcus agalactiae, that secrete capsular polysaccharide and methods of purifying the secreted bacterial capsular polysaccharides from culture medium. The extracted polysaccharides are useful for producing vaccines comprising the polysaccharides alone or conjugated to proteins..
Glaxosmithkline Biologicals Sa
|Humanized monoclonal antibodies and methodsof use|
The present invention comprises a humanized monoclonal antibody that binds to the human immunoglobulin heavy chain variable region germline gene vh1-69. This antibody is derived from mab g6 and recognizes the same epitope.
Dana-farber Cancer Institute, Inc.
|Monoclonal antibodies to interleukin 35 and methods of use thereof to inhibit regulatory t cell function|
Methods for regulating t cell function in a subject, particularly regulatory t cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an interleukin 35-specific binding agent, such as an antibody or small molecule inhibitor.
St. Jude Children's Research Hospital
Viral inhibitory nucleotide sequences and vaccines
The invention relates to inhibitory nucleotide signal sequences or “ins” sequences in the genomes of lentiviruses. In particular the invention relates to the agg motif present in all viral genomes.
Institute For Advanced Study
Particulate vaccine formulations for inducing innate and adaptive immunity
Disclosed are compositions, kits, and methods for inducing an immune response against an infection or a disease. The compositions typically include biodegradable particles having an average effective diameter that such that the biodegradable particles are phagocytosed by antigen presenting cells when the biodegradable particles are administered to a subject in need thereof.
Toll-like receptor 2 agonists and vaccines and uses thereof
The present invention relates to toll-like receptor 2 (tlr2) agonists, in particular, to tlr2-activating lipoproteins, and more particularly to tlr2-activating lipopeptides derived from the bacteria bordetella pertussis. The invention further extends to the use of said tlr2-activating lipoproteins as a therapeutic or as part of a vaccine composition in the treatment and prevention of infectious diseases, cancer or allergic diseases..
The Provost, Fellows, Foundation Scholars & The Other Members Of Board, Of The College Of The Holy
Multivalent vlp conjugates
The invention is directed to vaccines comprising capsular polysaccharides conjugated to one or more components of virus like particles (vlp), and methods for the administration of and methods for the manufacture of vaccines of the invention. Preferably vaccines of the invention generate a therapeutically effective response in an individual in need thereof to multiple strains and/or serotypes of the same or of different infectious agents.
Salmonella choleraesuis-salmonella typhimurium vaccines
The present invention relates methods of reducing fecal shedding of animals infected with salmonella by use of a vaccine or immunogenic composition of salmonella choleraesuis-typhimurium.. .
Boehringer Ingelheim Vetmedica, Inc.
Ehrlichial invasin for immuniztion, diagnosis, and cell delivery
Disclosed are vaccines containing one or more immunogenic polypeptides derived from an etpe protein from an ehrlichia sp. Or nucleic acid encoding these polypeptides.
Ohio State Innovation Foundation
Mesothelin vaccines and model systems
Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic t cell response.
The Johns Hopkins University
Malaria vaccines based on pre-erythrocytic antigens from p. falciparum
The present invention relates to polypeptides or fragments thereof for use as malaria vaccines. It also relates to nucleic acid molecules coding for the polypeptides of the invention.
Xenoantigen-displaying anti-cancer vaccines and making
Compositions, methods of making, and methods of using, xenoantigen-displaying anti-cancer vaccines are described.. .
The University Of Toledo
Antigen specific multi epitope vaccines
The presently described subject matter relates to cancer vaccines composed of the signal peptide domain of tumor associated antigens or proteins. The described peptide vaccines have multiple mhc class i and class ii epitopes which are highly abundant in the population.
Vaxil Biotherapeutics Ltd.
Therapeutic cancer vaccine targeted to haah (aspartyl-[asparaginyl]-beta-hydroxylase)
The present invention encompasses a cancer vaccine therapy targeting aspartyl-[asparaginyl]-beta.-hydroxylase (haah). The present invention contemplates bacteriophage expressing haah peptide fragments and methods for using said bacteriophage in methods of treating cancer..
Panacea Pharmaceuticals Inc.
Parainfluenza virus 5 based vaccines
The present invention provides safe, stable, efficacious, and cost-effective vaccines based on viral expression vectors that include a parainfluenza virus 5 (piv5) genome including a heterologous nucleotide sequence expressing a heterologous polypeptide.. .
University Of Georgia Research Foundation, Inc.
Attenuated viruses useful for vaccines
This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject.
The Research Foundation For The State University Of New York
The invention provides chimeric proteins and nucleic acids encoding these which can be used to generate vaccines against selected antigens. In one aspect, a chimeric protein comprises an antigen sequence and a domain for trafficking the protein to an endosomal compartment, irrespective of whether the antigen is derived from a membrane or non-membrane protein.
The Johns Hopkins University
Vesicular stomatitis virus for prime boost vaccine
The present invention relates to vesicular stomatitis virus (vsv) matrix (m) protein mutants. One mutant m protein includes a glycine changed to a glutamic acid at position 21, a leucine changed to a phenylalanine at position 111 and a methionine changed to an arginine at position 51.
The University Of Western Ontario
Novel european prrsv strain
The present invention is related to improved modified live prrs vaccines containing new prrsv european strains of prrsv and methods of use and manufacture of such vaccines.. .
Boehringer Ingelheim Vetmedica Gmbh
Compositions, methods and uses for thermally stable human papillomavirus formulations
Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (hpv) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing hpv formulations in the presence or absence of adjuvants.
The Regents Of The University Of Colorado, A Body Corporate
Vlp stabilized vaccine compositions
The invention is directed to compositions and methods for the stabilization of viral and bacterial vaccines. Vaccines of the invention are contained in vlps with stabilizing agents such as, for example, sugar alcohols (e.g., sorbitol) and degraded gelatins.
Gna1870-based vesicle vaccines for broad spectrum protection against diseases caused by neisseria meningitidis
The present invention generally provides methods and compositions for eliciting an immune response against neisseria spp. Bacteria in a subject, particularly against a neisseria meningitidis serogroup b strain..
Children's Hospital & Research Center Oakland
Virulence factors of streptococcus pnuemoniae
The present invention provides proteins/genes, which are essential for survival, and consequently, for virulence of streptococcus pneumoniae in vivo, and thus are ideal vaccine candidates for a vaccine preparation against pneumococcal infection. Further, also antibodies against said protein(s) are included in the invention..
Stichting Katholieke Universiteit/radboud University Nijmegen Medical Centre
The present invention relates to a vaccine capable to induce production of antibodies directed to pcsk9 in vivo.. .
Vaccine delivery systems using yeast cell wall particles
The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines..
Orbis Health Solutions, Llc
Fast diagnosis and personalized treatments for acne
Methods of diagnosing and treating patients afflicted with acne, including diagnosing one as having acne if the individual possesses rt4, rt5, rt7, rt8, rt9, or rt10. Methods for treating acne include administering an effective amount of a drug specifically targeting rt4, rt5, rt7, rt8, rt9, or rt10, such as small molecules, antisense molecules, sirnas, biologics, antibodies, phages, vaccines, or combination thereof..
The Regents Of The University Of California
Pestivirus vaccines for congenital tremors
The present invention relates to a vaccine for protecting a piglet against diseases associated with a novel pestivirus. The vaccine commonly includes a pestivirus antigen and, optionally an adjuvant.
Iowa State University Research Foundation, Inc.
Aspects of the present invention relate to chimeric polypeptides including hcv ns3/4a sequences and t-cell epitopes. Embodiments include nucleic acids encoding the chimeric ns3/4a polypeptides, the encoded polypeptides, compositions containing said nucleic acids, compositions containing said chimeric polypeptides, as well as methods of making and using the aforementioned compositions including, but not limited to medicaments and vaccines..
Chrontech Pharma Ab
Pyrrolo[3,2-d]pyrimidine derivatives as inducers of human interferon
Wherein r1 is hydrogen, methyl or —(ch2)2or3, r2 is methyl or —(ch2)2or4, or r1 and r2, together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl wherein the 6-membered heterocyclyl is optionally substituted by two hydroxy substituents; r3 and r4 are each independently hydrogen or methyl; and n is an integer having a value of 5 or 6, are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment or prevention of various disorders, for example the treatment or prevention of allergic diseases and other inflammatory conditions, for example allergic rhinitis and asthma, infectious diseases and cancer, and may also be useful as vaccine adjuvants..
Ultrafiltration unit for continuous buffer or medium exchange from a protein solution
The invention relates to an ultrafiltration unit for continuous buffer or medium exchange, a method for continuous buffer or medium exchange in the ultrafiltration unit, and a plant in particular for (semi)continuous production of biopharmaceutical and biological macromolecular products in particular, such as proteins, e.g. Monoclonal antibodies and vaccines, comprising the ultrafiltration unit according to the invention..
Virus like vesicles (vlvs) based vaccines to prevent or treat chronic hepatitis b virus (hbv) infection
The present invention relates to the discovery of compositions and methods for therapeutic immunization for treatment of chronic hepatitis b. Methods of the invention include a method generating an evolved high titer hybrid-hepatitis b virus (hbv) vector, methods of treating and/or preventing hbv, and methods of inducing a memory t and b cell immune response against hbv infection in a subject administered the vlv composition produced thereby.
The present invention relates to a novel porcine parvovirus, to proteins of the virus and to vaccines based upon the virus and proteins thereof. The invention also relates to dna fragments comprising a gene of the virus and to dna vaccines based upon genes of the virus.
Biomarkers for prostate cancer and methods for their detection
The invention provides a method for predicting the clinical response to a cancer vaccine in a patient having cancer, a method for determining the immune response to a cancer vaccine in a patient having cancer who has been administered a cancer vaccine, a method for determining the long-term survival in a patient having cancer, corresponding kits therefor, as well as methods of for improving the efficacy of a virus-based vaccine.. .
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
A novel downstream process for purifying polysaccharides
The present invention relates to a novel process for purifying bacterial polysaccharide. It is an efficient and scalable process for removing impurities from neisseria meningitidis serogroup c (men-c) polysaccharide which is capable of being used as such in a derivatized form or linked to other molecules, for the preparation of vaccines, more particularly conjugate vaccines for n.
Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd.
Filarial nematode vaccines, polypeptides, and nucleic acids
The present invention relates to vaccines comprising a shk domain of a filarial nematode protein. These vaccines may be used for the prevention and/or treatment of filarial nematode infections.
Therapeutic hpv18 vaccines
Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against hpv18 and/or hpv16.. .
Janssen Vaccines & Prevention B.v.
Apparatus and methods for self-administration of vaccines and other medicaments
A medicament delivery device includes a housing, a medicament container disposed within the housing, an activation mechanism, a cover and an electronic circuit system. The activation mechanism includes an energy storage member configured to produce a force to deliver the dose of a medicament and/or vaccine.
Influenza antigen delivery vectors and constructs
The present invention relates to fluorocarbon vectors for the delivery of influenza antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-influenza antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics in animals, including humans..
Altimmune Uk Limited
Epitopes cross-reactive between hsv-1, hsv-2 and vzv and methods for using same
The invention provides epitopes of hsv and vzv that are cross-reactive and are useful for the prevention and treatment of alphaherpesvirus infection. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against whole virus.
University Of Washington
Vaccine candidates against johne's disease
A composition and method for immunizing a mammal infected with mycobacterium are disclosed. The genes gcpe, psta, kdpc, papa2, impa, umaa1, fabg2_2, aceab, mbth2, ipqp, map0834c, cspb, lipn, and map1634 of m.
Wisconsin Alumni Research Foundation
Vaccines based on hepatitis b core antigens
The invention provides a protein comprising hepatitis b core antigen (hbcag) with a sugar attached to an e1 loop. The protein may comprise a first and a second copy of hbcag in tandem, wherein one or both copies of hbcag has a sugar attached to the e1 loop.
Compositions and methods for identifying and targeting cancer cells of alimentary canal origin
Screening and diagnostic reagents, kits and methods for primary and/or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or metastatic stomach or esophageal cancer are disclosed.
Thomas Jefferson University
Compositions comprising angiogenic factors and methods of use thereof
The present invention provides recombinant listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a pest-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.. .
The Trustees Of The University Of Pennsylvania