Vaccine

Vaccine-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic ...
Erasmus University Medical Center Rotterdam
May 18, 2017 - N°20170137899

Provided is an isolated mammalian negative strand rna virus, metapneumovirus (mpv), within the sub-family pneumoviridae, of the family paramyxoviridae. Also provided are isolated mammalian negative strand rna viruses identifiable as phylogenetically corresponding or relating to the genus metapneumovirus and components thereof. In particular, provided is a mammalian mpv, subgroups and variants thereof. Also provided are genomic nucleotide sequences of different ...
Recombinant poxviral vectors expressing both rabies and ox40 proteins, and vaccines made therefrom
Merial, Inc.
May 18, 2017 - N°20170137843

The present invention provides vectors that contain and co-express in vivo or in vitro immunogenic polypeptides or antigens together with an ox40l polypeptide, which functions as a genetic adjuvant. Together, the immunogenic polypeptide and the ox40l polypeptide elicit an immune response in animal or human, which is greater than the immune response elicited by the immunogenic polypeptide alone. ...
Vaccines and monoclonal antibodies targeting truncated variants of osteopontin and uses thereof
Affiris Ag
May 18, 2017 - N°20170137509

The present invention provides monoclonal antibodies specific for one or more truncated variants of human osteopontin and vaccines comprising at least one isolated osteopontin peptide, as well methods for manufacturing said antibodies and vaccines. Furthermore, a diagnostic method making use of said antibodies is provided. Said antibodies and vaccines are used in therapy, especially in treatment and/or prevention of ...
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Rna vaccines
Biontech Rna Pharmaceuticals Gmbh
May 18, 2017 - N°20170136121

A rna vaccine containing a rna molecule encoding an allergen or derivative thereof, in which the allergen is an allergen of alnus glutinosa, alternaria alternata, ambrosia artemisiifolia, apium graveolens, arachis hypogaea, betula verrucosa, carpinus betulus, castanea sativa, cladosporium herbarum, corylus avellana, cryptomeria japonica, cyprinus carpio, daucus carota, dermatophagoides pteronyssinus, fagus sylvatica, felis domesticus, hevea brasiliensis, juniperus ashei, malus domestica, quercus ...
Effective vaccination against porcine reproductive and respiratory syndrome (prrs) virus prior to weaning
Zoetis Services Llc
May 18, 2017 - N°20170136117

The invention provides isolated polynucleotide molecules that comprise a dna sequence encoding an infectious rna sequence encoding a genetically-modified north american prrs virus, methods to make it and related polypeptides, polynucleotides, and various components. Vaccines comprising the genetically modified virus and polynucleotides and a diagnostic kit to distinguish between naturally infected and vaccinated animals are also provided.
North american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof
Zoetis Services Llc
May 18, 2017 - N°20170136116

The invention provides isolated polynucleotide molecules that comprise a dna sequence encoding an infectious rna sequence encoding a genetically-modified north american prrs virus, methods to make it and related polypeptides, polynucleotides, and various components. Vaccines comprising the genetically modified virus and polynucleotides and a diagnostic kit to distinguish between naturally infected and vaccinated animals are also provided.
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Vaccines comprising heat-sensitive transgenes
Uvic Industry Partnerships Inc.
May 18, 2017 - N°20170136111

The present disclosure provides temperature sensitive essential nucleic acid molecules from a psychrophilic bacterium, proteins encoded by the nucleic acid molecules, as well as recombinant cells into which have been introduced such nucleic acid molecules. The disclosed recombinant cells containing one or more essential nucleic acid molecules from a psychrophilic bacterium are thereby made temperature sensitive, and can be administered ...
Dna vector and transformed tumor cell vaccines
Morphogenesis, Inc.
May 18, 2017 - N°20170136109

Customized whole cell cancer vaccines can be produced from autologous (ex vivo or in situ) or allogeneic human or veterinary patient cell lines. Cells are transformed with s. Pyogenes dna that expresses an emm protein on the cell surface and cytosol. Treatment of cancer patients with an emm vector vaccine induces an immunologic response to the cancer by enhancing immunogenicity ...
Reagents and methods for detecting influenza
Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health
May 11, 2017 - N°20170131277

Two universally conserved sequences from influenza type a neuraminidases were identified by large scale sequence analysis then chemically modified and conjugated to carrier proteins to generate mono-specific and monoclonal antibodies. The two antibodies, one targeting the n-terminus of the type a neuraminidase and the other sequence close to enzymatic active site, were capable of binding to all 9 subtypes of neuraminidase ...
Preparation methods for a novel generation of biological safe klh products used for cancer treatment, ...
Biosyn Arzneimittel Gmbh
May 11, 2017 - N°20170129928

The present invention relates to the provision of a biologically safe hemolymph sera, preferably hemocyanin, more preferably klh (keyhole limpet hemocyanin). A method for producing virus free hemocyanin is provided.
Vaccine adjuvants
Purdue Research Foundation
May 11, 2017 - N°20170128567

The present invention provides a new adjuvant for administering vaccines.
Polyvalent influenza virus-like particles (vlps) and use as vaccines
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
May 11, 2017 - N°20170128562

This disclosure provides compositions that include a mixture of viral like particles (vlps), expressing different individual influenza hemagglutinin (ha) proteins that elicit broadly reactive immune responses to a wide variety of influenza viruses. For example, the composition can include at least two different influenza vlps, a first vlp comprising a first ha polypeptide and a second vlp comprising a second ...
Attenuated mannheimia haemolytica vaccines and methods of making and use
The United States Of America As Represented By The Secretary Of Agriculture
May 11, 2017 - N°20170128560

The present invention provides attenuated m. Haemolytica strains that elicit an immune response in animals against m. Haemolytica, compositions comprising said strains, methods of vaccination against m. Haemolytica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping ...
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Rhinovaccination system of influenza vaccine
Toko Yakuhin Kogyo Kabushiki Kaisha
May 11, 2017 - N°20170128363

The present invention relates to a rhinovaccination system of influenza vaccine, comprising a medical syringe filled with an influenza vaccine composition which comprises an inactivated whole influenza virion and a gel base material comprising carboxy vinyl polymer to administer the influenza vaccine composition to nasal mucosa, which is characterized by not comprising an adjuvant.
Vaccine preparation using ultraviolet radiation
Sensor Electronic Technology, Inc.
May 04, 2017 - N°20170121701

An approach for preparing a vaccine using ultraviolet radiation is described. Aspects of this approach involve multiple iterations of inactivation of the vaccine using an ultraviolet radiation source at a set of different wavelengths and dosages. A recognition test of the vaccine using the set of different wavelengths and dosages is performed after the multiple iterations of inactivation. A controller ...
Integrin heterodimer and a subunit thereof
Xintela Ab
May 04, 2017 - N°20170121386

A recombinant or isolated integrin heterodimer comprising a novel subunit α10 in association with a subunit β is described. The α10 integrin may be purified from bovine chondrocytes on a collagen-type-ii affinity column. The integrin or the subunit of α10 can be used as a marker or target of all types of cells, e. G. Of ...
Preparation methods for a novel generation of biological safe klh products used for cancer treatment, ...
Biosyn Arzneimittel Gmbh
May 04, 2017 - N°20170121376

The present invention relates to the provision of a biologically safe hemolymph sera, preferably hemocyanin, more preferably klh (keyhole limpet hemocyanin). The hemocyanin is purified using anion exchange chromatography.
Expression and conformational analysis of engineered influenza hemagglutinin
Sanofi Pasteur Inc.
May 04, 2017 - N°20170121373

The present invention provides, among other things, compositions and methods for analyzing the expression and conformation of engineered influenza hemagglutinin in particular, the present invention provides methods of screening in silico designed ha antigens using neutralizing antibody panels specific to conserved epitopes. In some embodiments, the has are down selected for inclusion in universal influenza vaccines based upon their binding ...
Use of vista agonists and antagonists to suppress or enhance humoral immunity
Immunext Inc.
May 04, 2017 - N°20170119877

The present invention is directed to the use of vista agonists alone or in association with other immune inhibitors, preferably another inhibitor of humoral immunity such as an inos/no promoter or nitric oxide or a pd-1 or pd-l1 agonist or a cd40 antagonist for the treatment or prevention of conditions wherein the suppression of humoral immunity is therapeutically beneficial. ...
Soluble needle arrays for delivery of influenza vaccines
Seqirus Uk Limited
May 04, 2017 - N°20170119872

Influenza vaccines are administered using solid biodegradable microneedles. The microneedles are fabricated from the influenza vaccine in combination with solid excipient(s) and, after penetrating the skin, they dissolve in situ and release the vaccine to the immune system. The influenza vaccine is (i) a purified influenza virus surface antigen vaccine, rather than a live vaccine or a whole-virus or ...
Low-additive influenza vaccines
C/o Novartis Vaccines & Diagnostics Gmbh & Co Kg
May 04, 2017 - N°20170119871

An influenza vaccine lacks at least three of: a mercurial preservative; an antibiotic; formaldehyde; and egg-derived materials. In some embodiments, the vaccine includes none of these four components.