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Vaccination

Vaccination-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Piv5-based amplifying virus-like particles
University Of Georgia Research Foundation, Inc.
February 15, 2018 - N°20180044644

Compositions, methods of use and methods of manufacture are provided for piv5-based amplifying vlp (avlp) that can deliver an expressible heterologous nucleotide sequence in target cells without producing progeny, and which demonstrate useful safety and therapeutic efficacy in multiple animal and human health applications, such as vaccination, gene therapy and cancer therapy.
NEW Non-neuroinvasive viruses and uses thereof
Trustees Of Tufts College (aka Tufts University)
February 15, 2018 - N°20180044643

Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
NEW Influenza virus vectors and uses therefor
Flugen, Inc.
February 15, 2018 - N°20180043007

Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant m2 sequence, and are useful in immunogenic compositions, e. G., as vaccines. The mutant viruses disclosed herein including a mutant m2 sequence are also useful to deliver antigens to a subject, e. G., to induce an ...
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Combined vaccination/radioterapy for cancer treatment
Universite De I'ecole De Medecine
February 08, 2018 - N°20180036368

Disclosed is a composition for use in the prevention or treatment of a subject suffering from a cancer in combination with radiotherapy, wherein the composition includes a conjugate, eventually associated with pharmaceutically acceptable carrier, the conjugate including i) the shiga toxin b subunit (stxb), a fragment or a derivative thereof; and ii) at least one epitope associated with the cancer.
Devices for immune-related risk assessment
February 01, 2018 - N°20180031547

Portable devices for anti-drug antibody (ada) testing, to estimate safety and/or efficacy of therapeutic agents are provided. These devices can be used to perform point of care risk assessment for various applications, including but not restricted to one or more of the following: selection of therapeutic drug for patient treatment; evaluation of the need to change therapeutic drug or ...
Compositions and methods for treatment of cancer
February 01, 2018 - N°20180028639

Here we show that seg/sei presented from a hla-dq8 (hla-dqb*0302 and hla-dqa*0301) platform prevent the de novo outgrowth (vaccination) of lewis lung carcinoma (llc) and b16-f10 melanoma and retard the growth of established tumors with no significant toxicity. Vaccination of dq8 tg mice with irradiated llc or b16-f10 melanoma followed by seg/sei immunization and live tumor ...
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Targeted radiotherapy chelates for in situ immune modulated cancer vaccination
January 25, 2018 - N°20180021461

Wherein r1 comprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or auger emitting metal isotope with a half life of greater than 6 hours and less than 30 days. In one such embodiment, a is 1, n is 18, m is 0, b is 1, and r2 is —n+(ch3)3.
In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus-like ...
Kuros Biosciences Ag
January 18, 2018 - N°20180015160

The invention relates to the finding that stimulation of antigen presenting cell (apc) activation using substances such as anti-cd40 antibodies or dna oligomers rich in non-methylated c and g (cpgs) can dramatically enhance the specific t cell response obtained after vaccination with recombinant virus like particles (vlps) coupled, fused or otherwise attached to antigens. While vaccination with recombinant vlps fused ...
Stable, spray dryed, immunogenic, viral compositions
Aeras
January 18, 2018 - N°20180015158

Viruses, and particularly genetically engineered, replication deficient viruses such as adenoviruses, poxviruses, mva viruses, and baculoviruses which encode one or more antigens of interest, such as tb, malarial, and hiv antigens, are spray dried with a mannitol-cyclodextrin-trehalose-dextran (mctd) to form a powder where the viability of the viruses are maintained at a suitable level for mass vaccinations after spray drying, ...
Attenuated pasteurella multocida vaccines & methods of making & use thereof
Merial Inc.
January 18, 2018 - N°20180015157

The present invention provides attenuated p. Multocida strains that elicit an immune response in animal p. Multocida, compositions comprising said strains, methods of vaccination against p. Multocida, and kits for use with such methods and compositions. The invention further provides novel, genetically-engineered mutations in p. Multocida hyad and nanpu genes, which are useful in the production of novel attenuated p. ...
Combination of protein forms for hornfly vaccination
Auburn University
January 18, 2018 - N°20180015155

Thrombostasin is an anti-clotting protein found in saliva of haematobia irritans. Disclosed herein are studies testing blood uptake of horn flies feeding on cattle which confirm the association of ts genotype with blood uptake of horn flies. Blood uptake volumes of homozygous ts10 horn flies were lower than those of other ts genotypes when fed on control cattle. Cattle vaccinated ...
Radiohalogenated agents for in situ immune modulated cancer vaccination
January 18, 2018 - N°20180015154

Wherein r1 is a radioactive halogen isotope, n is 18 and r2 is —n+(ch3)3.
Modulation of antigen immunogenicity by deleting epitopes recognized by nkt cells
Imnate Sarl
January 11, 2018 - N°20180009843

The invention describes a method and compounds for the prevention of immune responses towards allofactors, towards viral vectors used for gene therapy and gene vaccination, towards proteins to which subjects are naturally exposed, towards genetically-modified organisms and towards undesirable effects related to vaccine administration for allergic or infectious diseases.
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Adaptation of attenuated infectious bronchitis virus (ibv) to embryonic kidney cells and vaccine thereby produced
Auburn University
January 11, 2018 - N°20180008698

Disclosed are methods for preparing a vaccine against infection by infectious bronchitis virus (ibv). The methods typically include passing a heterogeneous attenuated population of ibv in chicken embryonic kidney cells, and optionally may include further passaging the heterogeneous attenuated population of ibv in embryonated chicken eggs (ece) in order to obtain passaged attenuated population of ibv. Also disclosed are passaged ...
Influenza virus vaccination regimens
Icahn School Of Medicine At Mount Sinai
January 11, 2018 - N°20180008696

Provided herein are immunization regimens for inducing an immune response (e. G., an antibody response) against influenza virus. In specific aspects, the immunization regimens involve the administration of a chimeric hemagglutinin (ha), a headless ha or another influenza virus stem domain based construct (e. G., the ha stem domain or a fragment thereof) to a subject. In certain aspects, the ...
Immunogenic compositions for use in pneumococcal vaccines
Pfizer Inc.
January 04, 2018 - N°20180000922

An object of the present invention is to provide immunogenic compositions for protection against s. Pneumoniae, in particular against s. Pneumoniae serogroup 9, while limiting the number of conjugates. The present invention thereforerelates to new immunogenic compositions for use in pneumococcal vaccines and to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said immunogenic compositions.
Methods and compositions for ebola virus vaccination
Etubics Corporation
December 28, 2017 - N°20170368161

Methods for generating immune responses to ebola virus antigens using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.
Characterization of adaptive immune response to vaccination or infection using immunosequencing
Fred Hutchinson Cancer Research Center
December 21, 2017 - N°20170362653

Methods of monitoring and measuring dynamic adaptive immune cell responses are provided. High-throughput sequencing of t cell receptor and immunoglobulin loci is used to characterize the breadth of an effector cell response to a stimulus, such as a vaccine or infection. Unique responding effector cell clones and abundance thereof can be determined. Additionally, methods for determining the contribution of responding ...
System and method for fowl vaccination
The University Of Georgia Research Foundation, Inc .
December 21, 2017 - N°20170360540

A method, apparatus and system for delivery of live or attenuated viral and bacterial vaccines to fowl are described.
Nanoelectroablation control and vaccination
Pulse Biosciences, Inc.
December 21, 2017 - N°20170360504

Techniques for treating a tumor and vaccinating against cancer are described. The techniques include treating the tumor by positioning electrodes over an interface between the tumor and non-tumor tissue and applying sub-microsecond pulsed electric fields. The positioning is facilitated by an imaginary contour line of a threshold value of the electric field. In an example, the imaginary contour line is ...
Vaccination methods
Turnstone Limited Partnership
December 07, 2017 - N°20170348404

In one aspect, a method of treating cancer in a mammal is provided. The method comprises administering to the mammal an oncolytic vector that expresses a tumour antigen to which the mammal has a pre-existing immunity. In another aspect, a method of boosting immune response in a mammal having a pre-existing immunity to an antigen is provided comprising intravenous administration ...
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