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Vaccination-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

Vaccination methods
Turnstone Limited Partnership
December 07, 2017 - N°20170348404

In one aspect, a method of treating cancer in a mammal is provided. The method comprises administering to the mammal an oncolytic vector that expresses a tumour antigen to which the mammal has a pre-existing immunity. In another aspect, a method of boosting immune response in a mammal having a pre-existing immunity to an antigen is provided comprising intravenous administration ...
Determining antigen recognition through barcoding of mhc multimers
Immudex Aps
November 30, 2017 - N°20170343545

The present invention describes the use of nucleic acid barcodes as specific labels for mhc multimers to determine the antigen responsiveness in biological samples. After cellular selection the barcode sequence will be revealed by sequencing. This technology allows for detection of multiple (potentially >1000) different antigen-specific cells in a single sample. The technology can be used for t-cell epitope ...
Composition comprising antigens and a mucosal adjuvant and a method for using
Phibro Animal Health Corporation
November 16, 2017 - N°20170326226

The majority of the mortality observed in young pigs occurs between three and five weeks post-weaning for s. Suis infections and between four and six weeks post-weaning for h. Parasuis and actinobacillus suis infections. Clinical disease control associated with s. Suis, a. Suis and h. Parasuis has been attempted using antibiotic treatment, by controlled exposure with live organisms, and by ...
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Long peptides of 22-45 amino acid residues that induce and/or enhance antigen specific immune ...
Academisch Ziekenhuis Leiden
November 09, 2017 - N°20170320915

Epitopes derived from human papilloma virus and peptides having a size of about 22-45 amino acid residues comprising minimal t cell epitopes are disclosed. Also disclosed are clinically relevant approaches for immunizing subjects against (myco) bacterially and/or virally infected cells or tumor cells. Peptide sequences of 22-35 amino acid residues in length can induce both peptide-specific cd8+ cytolytic cells ...
Vaccination delivery system and method
Mayo Foundation For Medical Education And Research
October 26, 2017 - N°20170304557

A device can be used for delivering a dose of a vaccine, medicine, medication, drug, or prescription. For example, this document describes a wearable vaccination device that plays an audible sound or musical tune for distracting or entertaining the patient while an intradermal vaccine is delivered via the patient's skin. The control portion of the wearable vaccination device includes a ...
Vaccination of immunocompromised subjects
Seqirus Uk Limited
October 26, 2017 - N°20170304429

Disclosed herein are methods for enhancing immune responses to a vaccine in immunocompromised individuals, including those receiving a statin therapy. Related products are also provided.
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Silvestrol, silvestrol analogs and uses thereof
Ohio State Innovation Foundation
October 26, 2017 - N°20170304261

Disclosed herein are treatment methods, vaccination methods, compositions, co-therapeutic methods, combination therapeutic compositions and kits comprising silvestrol and silvestrol analogs alone or in combination with therapeutic and preventative therapies. Disclosed herein are also methods, compositions and kits that can be used to treat cancer, viral infections, to modulate the immune system or as preventative therapies.
Computerized event simulation using synthetic populations
Ohio State Innovation Foundation
October 19, 2017 - N°20170300657

Systems, methods, and computer-readable media for simulating the course of an event are provided. A processing unit can receive attributes of a synthetic population and select a synthetic-population graph from a data library based at least in part on the attributes. The processing unit can receive data of an intervention designed to affect the course of the event. The processing ...
Immune system stimulating nutrition
Ohio State Innovation Foundation
October 19, 2017 - N°20170296563

Disclosed is a nutritional composition comprising a combination of non-digestible oligosaccharides and a product obtained by incubating an aqueous substrate by bifidobacteria and optionally a product obtained by incubating an aqueous substrate by s. Thermophilus. Said combination synergistically improves the immune system by stimulating the th1 response, and/or decreasing the th2 response, improving the vaccination response, improving the resistance ...
Th1 vaccination priming for active immunotherapy
Immunovative Therapies, Ltd.
October 05, 2017 - N°20170281743

The present invention includes vaccine compositions and methods for using these vaccine compositions in active immunotherapy. The vaccine compositions include allogeneic activated th1 memory cells. The compositions can also include one or more disease-related antigens. The methods include administering the vaccine compositions to provide a th1 footprint in normal individuals or patients susceptible to disease or having minimal residual disease.
Muscle-specific nucleic acid regulatory elements and methods and use thereof
Universiteit Gent
September 28, 2017 - N°20170275649

The present invention relates to nucleic acid regulatory elements that are able to enhance muscle-specific expression of genes, in particular expression in cardiac muscle and/or skeletal muscle, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. The present invention is particularly useful for applications using ...
Cytotoxic t lymphocyte inducing immunogens for prevention treatment and diagnosis of dengue virus infection
Emergex Vaccines Holdings Limited
September 28, 2017 - N°20170275338

Dengue fever (df) and dengue hemorrhagic fever (dhr) are significant global public health problems and understanding the overall immune response to infection will contribute to appropriate management of the disease and its potentially severe complications. Live attenuated and subunit vaccine candidates, which are under clinical evaluation, induce primarily an antibody response to the virus and minimal cross-reactive t cell responses. ...
Development of methods for production of a whole virus vaccine candidate stock and novel adaptive ...
Hvidovre Hospital
September 28, 2017 - N°20170274067

The present invention relates to methods for obtaining a whole virus vaccine candidate stock. The present invention also relates to an inactivated whole virus vaccine candidate stock that can be used for vaccination purposes as well as development of novel high titer virus, which is the preferred virus for this technique.
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Mobile pharmacy
Kansas State University Research Foundation
September 21, 2017 - N°20170270275

A mobile pharmacy may provide services for a group of people who have similar medical considerations. For example, a group intending to visit another country may require certain vaccinations or medications. For another example, a group of people working at a common employer may have medical requirements related to a chronic disease. A mobile pharmacy may allow a pharmacist to ...
Method for regressing pancreatic tumor by a liposomal formulation along with dna vaccines
Mayo Clinic
September 21, 2017 - N°20170267719

The present invention discloses a plectin-1 receptor targeting novel cationic ktllptpk-lipopeptide. The present invention further discloses a liposomal formulation comprising the cationic ktllptpk-lipopeptide, at least two co-lipids, therapeutic agents and a pharmaceutically acceptable carrier. The present invention also provides a method for regressing established pancreatic tumors comprising administering therapeutically effective amount of the liposomal formulation with the therapeutic agents in ...
Flagellin-based agents and uses including effective vaccination
Cleveland Biolabs, Inc.
September 21, 2017 - N°20170266278

The present invention relates to, in part, compositions comprising improved flagellin derived constructs and methods of using for vaccination, including adjuvants comprising flagellin-based agents.
Vaccination in newborns and infants
Curevac Ag
September 21, 2017 - N°20170266268

The present invention relates to vaccines comprising at least one mrna encoding at least one antigen for use in the treatment of a disease in newborns and/or infants, preferably exhibiting an age of not more than 2 years, preferably of not more than 1 year, more preferably of not more than 9 months or even 6 months, wherein the treatment comprises vaccination of ...
Methods for monitoring cd4+ t-helper type 1 response in cancer and immune restoration
The Trustees Of The University Of Pennsylvania
September 14, 2017 - N°20170261508

A method for diagnosing or treating a mammalian subject having, or at risk of developing cancer, comprising: generating a circulating anti-cancer cd4+ th1 response from antigen presenting cells or their precursors and cd4+ t-cells from a sample of said subject's blood which causes secretion of interferon-gamma (“ifn-γ”); and detecting said anti-cancer cd4+ th1 response ...
Novel mucosal vaccination approach for herpes simplex virus type-2
Biomedical Research Models, Inc.
September 14, 2017 - N°20170258894

The invention provides methods and kits for immunizing animals (e. G. Mammals) against viral antigens, including herpes-simplex virus type 2. The protective immune response elicited by the methods and kits of the invention is characterized by robust humoral, cellular, and mucosal immunity. In particular, the invention provides a heterologous immunization method comprising a priming dna vaccine encoding an antigen and a ...
Fusion protein comprising streptococcal antigen
Stichting Katholieke Universiteit
September 14, 2017 - N°20170258885

The disclosure provides a fusion protein comprising at least one antigenic fragment of a protein from a bacterium from genus streptococcus, as well as means for its expression. Outer membrane vesicles and vaccines comprising the fusion protein are also disclosed, as well as a method of vaccination using such vaccines.
Annexin a2 as immunological target
The Johns Hopkins University
September 14, 2017 - N°20170258881

Annexina2 (anxa2), a member of the annexin family of calcium-dependent, phospholipid binding proteins, is one of a panel of identified antigens recognized by the post-vaccination sera of patients who demonstrated prolonged disease-free survival following multiple vaccinations. Annexina2 is abundantly expressed in pancreatic adenocarcinomas and cell surface/membrane annexina2 increases with the progression from premalignant lesions to invasive pancreatic adenocarcinomas. The ...