Vaccination

Vaccination-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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NEW Compositions, kits and methods for in vitro antigen presentation, assessing vaccine efficacy, and assessing immunotoxicity ...
May 25, 2017 - N°20170146526

Nanoparticle-based compositions, assays, kits, methods and platforms for delivering an antigen (peptides, proteins) or a nucleic acid encoding an antigen to professional apcs (papcs) result in the generation of autologous apcs that present a natural peptide repertoire of the antigen for use in assessing the efficacy of a vaccine (e. G., a cytotoxic t lymphocyte (ctl) response to a particular ...
NEW Use of mcoln-1 modulators to regulate cell migration
May 25, 2017 - N°20170145423

The present invention relates to the use of modulators of mcoln-1 for modulating the cells migration, in particular the migration of dendritic cells and tumor cells, especially for antitumoral vaccination, autoimmune diseases treatment, and metastasis prevention.
NEW Antigen-loaded chitosan nanoparticles for immunotherapy
May 25, 2017 - N°20170143822

The present invention is directed to nanoparticles comprising chitosan and an antigen, whereby the chitosan has a degree of deacetylation of about 90% and a molecular weight from 5 kda to 80 kda, to microparticles containing such nanoparticles as well as to a process for preparation of such particles. The particles are usable for vaccination.
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NEW Method of treating melanoma
May 25, 2017 - N°20170143811

The present invention relates to a method of treating or preventing melanoma using vaccination or immunisation, wherein said vaccination or immunisation involves the use of a photosensitizing agent, a melanoma antigen (i. E. An antigenic molecule), for example a vaccine component, and irradiation with light of a wavelength effective to activate the photosensitizing agent. The invention also relates to said ...
NEW Tannin-chitosan composites
May 25, 2017 - N°20170142967

The invention provides a composition comprising a matrix of chitosan and a tannin wherein the chitosan is electrostatically bonded to the tannin to form a chitosan-tannin composite material. The chitosan can be partially or fully deacetylated, and the tannin can be a monomeric or an oligomeric proanthocyanidin or a hydrolysable tannin. The chitosan-tannin composite material can be a nanoparticle, a ...
Effective vaccination against porcine reproductive and respiratory syndrome (prrs) virus prior to weaning
Zoetis Services Llc
May 18, 2017 - N°20170136117

The invention provides isolated polynucleotide molecules that comprise a dna sequence encoding an infectious rna sequence encoding a genetically-modified north american prrs virus, methods to make it and related polypeptides, polynucleotides, and various components. Vaccines comprising the genetically modified virus and polynucleotides and a diagnostic kit to distinguish between naturally infected and vaccinated animals are also provided.
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Attenuated mannheimia haemolytica vaccines and methods of making and use
The United States Of America As Represented By The Secretary Of Agriculture
May 11, 2017 - N°20170128560

The present invention provides attenuated m. Haemolytica strains that elicit an immune response in animals against m. Haemolytica, compositions comprising said strains, methods of vaccination against m. Haemolytica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping ...
Rhinovaccination system of influenza vaccine
Toko Yakuhin Kogyo Kabushiki Kaisha
May 11, 2017 - N°20170128363

The present invention relates to a rhinovaccination system of influenza vaccine, comprising a medical syringe filled with an influenza vaccine composition which comprises an inactivated whole influenza virion and a gel base material comprising carboxy vinyl polymer to administer the influenza vaccine composition to nasal mucosa, which is characterized by not comprising an adjuvant.
Human cytomegalovirus vaccine compositions and method of producing the same
Fondazione Cariplo
May 04, 2017 - N°20170119874

The present invention provides for a vector and a gene expression system for producing a soluble pentameric protein complex comprising the hcmv glycoproteins ul128, ul130, ul131, gh and gl or sequence variants thereof, as well as vaccine compositions comprising the same. The present invention further provides for a vaccine composition for use in prophylactically or therapeutically vaccinating against hcmv infections. ...
Dengue virus specific multiple hla binding t cell epitopes for the use of universal vaccine ...
Immunotope, Inc.
May 04, 2017 - N°20170119869

Dengue fever (df) and dengue hemorrhagic fever (dhf) are significant global public health problems and understanding the overall immune response to infection will contribute to appropriate management of the disease and its potentially severe complications. Live attenuated and subunit vaccine candidates, which are under clinical evaluation, induce primarily an antibody response to the virus and minimal cross-reactive t cell responses. ...
Fusion molecule based on novel taa variant
The Regents Of The University Of California
May 04, 2017 - N°20170119866

This invention provides novel carbonic anhydrase (caix) nucleic acid and peptide sequences, as well as related methods and compositions, including anti-cancer immunogenic agent(s) (e. G. Vaccines and chimeric molecules) that elicit an immune response specifically directed against cancer cells expressing a caix antigenic marker. The novel caix variant and related compositions are useful in a wide variety of treatment ...
Vaccination compositions, methods of making, and methods of use
Stc.unm
April 27, 2017 - N°20170112912

This disclosure describes, generally, compositions and methods related to thermostable vaccine formulations, their storage, and their use. Generally, the thermostable vaccine formulations can be in the form of a dry powder. The dry powder formulations can increase the length of time that the vaccine remains viable under non-refrigerated, ambient temperature conditions.
Influenza virus vectors and uses therefor
Flugen, Inc.
April 20, 2017 - N°20170106077

Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant m2 sequence, and are useful in immunogenic compositions, e. G., as vaccines. The mutant viruses disclosed herein including a mutant m2 sequence are also useful to deliver antigens to a subject, e. G., to induce an ...
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Vaccination with immuno-isolated cells producing an immunomodulator
Maxivax Sa
April 06, 2017 - N°20170095546

Provided herein are vaccine compositions containing at least one retrievable biocompatible macrocapsule containing immuno-isolated allogeneic cells that secrete an immunomodulator such as gm-csf (granulocyte-macrophage colony stimulating factor) and an antigenic component such as autologous tumor cells or infectious agents. Also provided are kits and pharmaceutical compositions containing the vaccine compositions as well as methods of use thereof for therapeutic or ...
Inhibition of tumor angiogenesis by checkpoint inhibitors and active vaccination
Batu Biologics, Inc.
April 06, 2017 - N°20170095545

Disclosed are compositions of matter, methods, and protocols useful for treatment of cancer through induction of anti-angiogenic immune responses by vaccination together with immune modulation triggered by checkpoint inhibitors. The invention provides placenta, placental endothelial, placental fibroblasts, and mixtures thereof as immunogens, whose anti-angiogenic activity is augmented by utilization of checkpoint inhibitors. Means of differentiating tumor cells directly into endothelial ...
In ovo delivery of probiotic cultures
Biogaia Ab
April 06, 2017 - N°20170095516

The present invention generally relates to a strain of lactobacillus probiotic bacteria and a poultry vaccine for use in the in ovo vaccination of poultry, wherein said strain and said vaccine are administered to an embryonated poultry egg. Compositions suitable for use in an in ovo vaccination protocol for poultry comprising a strain of lactobacillus probiotic bacteria and a vaccine ...
Hendra virus recombinant compositions and uses thereof
Merial, Inc.
March 30, 2017 - N°20170087242

The present invention provides vectors that contain and express in vivo or in vitro one or more hendra virus polypeptides or antigens that elicit an immune response in animal or human against hendra virus and nipah virus, compositions comprising said vectors and/or hendra virus polypeptides, methods of vaccination against hendra virus and nipah virus, and kits for use with ...
Polypeptides derived from enterococcus and their use for vaccination and the generation of therapeutic antibodies
Universite De Caen Basse-normandie
March 30, 2017 - N°20170087239

Medicament for the treatment or the prevention of a bacterial infection, characterized in that it contains at least one polypeptide selected from the group of seq id no: 1 to seq id no: 9, and contiguous fragments thereof, wherein said at least one polypeptide or contiguous fragment thereof induces opsonic antibodies in a patient in need thereof. The polypeptides or the contiguous ...
Vaccination with immuno-isolated cells producing an immunomodulator
Maxivax Sa
March 30, 2017 - N°20170087234

Provided herein are vaccine compositions containing at least one retrievable biocompatible macrocapsule containing immuno-isolated allogeneic cells that secrete an immunomodulator such as gm-c sf (granulocyte-macrophage colony stimulating factor) and an antigenic component such as autologous tumor cells or infectious agents. Also provided are kits and pharmaceutical compositions containing the vaccine compositions as well as methods of use thereof for therapeutic ...
Vaccination composition
Cristal Delivery B.v.
March 23, 2017 - N°20170079918

The present invention is directed to vaccination composition comprising a particle comprising a polymer matrix incorporating an adjuvant and/or an antigen, to method of making them and use. Particularly, the present invention results in adjuvants and/or antigens, covalently entrapped in or coupled to polymer carriers or polymeric devices, such as micelles, nanoparticles, microspheres and other types of polymer ...
Tumor vaccination involving a humoral immune response against self-proteins
Biontech Ag
March 16, 2017 - N°20170072035

The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis b virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful ...