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Vaccination-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

Th1 vaccination priming for active immunotherapy
Immunovative Therapies, Ltd.
October 05, 2017 - N°20170281743

The present invention includes vaccine compositions and methods for using these vaccine compositions in active immunotherapy. The vaccine compositions include allogeneic activated th1 memory cells. The compositions can also include one or more disease-related antigens. The methods include administering the vaccine compositions to provide a th1 footprint in normal individuals or patients susceptible to disease or having minimal residual disease.
Muscle-specific nucleic acid regulatory elements and methods and use thereof
Universiteit Gent
September 28, 2017 - N°20170275649

The present invention relates to nucleic acid regulatory elements that are able to enhance muscle-specific expression of genes, in particular expression in cardiac muscle and/or skeletal muscle, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. The present invention is particularly useful for applications using ...
Cytotoxic t lymphocyte inducing immunogens for prevention treatment and diagnosis of dengue virus infection
Emergex Vaccines Holdings Limited
September 28, 2017 - N°20170275338

Dengue fever (df) and dengue hemorrhagic fever (dhr) are significant global public health problems and understanding the overall immune response to infection will contribute to appropriate management of the disease and its potentially severe complications. Live attenuated and subunit vaccine candidates, which are under clinical evaluation, induce primarily an antibody response to the virus and minimal cross-reactive t cell responses. ...
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Modified bat influenza viruses and their uses
Kansas State University Research Foundation
September 28, 2017 - N°20170274064

Vaccine compositions useful for vaccination against a target influenza strain, and method and kits for using the same. The vaccines comprise a live attenuated influenza virus that is synthetically constructed based upon a backbone platform derived from a bat influenza strain, and heterologous surface proteins ha and na derived from the target influenza strain. The live attenuated virus is non-reassortant ...
Mobile pharmacy
Kansas State University Research Foundation
September 21, 2017 - N°20170270275

A mobile pharmacy may provide services for a group of people who have similar medical considerations. For example, a group intending to visit another country may require certain vaccinations or medications. For another example, a group of people working at a common employer may have medical requirements related to a chronic disease. A mobile pharmacy may allow a pharmacist to ...
Method for regressing pancreatic tumor by a liposomal formulation along with dna vaccines
Mayo Clinic
September 21, 2017 - N°20170267719

The present invention discloses a plectin-1 receptor targeting novel cationic ktllptpk-lipopeptide. The present invention further discloses a liposomal formulation comprising the cationic ktllptpk-lipopeptide, at least two co-lipids, therapeutic agents and a pharmaceutically acceptable carrier. The present invention also provides a method for regressing established pancreatic tumors comprising administering therapeutically effective amount of the liposomal formulation with the therapeutic agents in ...
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Vaccination in newborns and infants
Curevac Ag
September 21, 2017 - N°20170266268

The present invention relates to vaccines comprising at least one mrna encoding at least one antigen for use in the treatment of a disease in newborns and/or infants, preferably exhibiting an age of not more than 2 years, preferably of not more than 1 year, more preferably of not more than 9 months or even 6 months, wherein the treatment comprises vaccination of ...
Methods for monitoring cd4+ t-helper type 1 response in cancer and immune restoration
The Trustees Of The University Of Pennsylvania
September 14, 2017 - N°20170261508

A method for diagnosing or treating a mammalian subject having, or at risk of developing cancer, comprising: generating a circulating anti-cancer cd4+ th1 response from antigen presenting cells or their precursors and cd4+ t-cells from a sample of said subject's blood which causes secretion of interferon-gamma (“ifn-γ”); and detecting said anti-cancer cd4+ th1 response ...
Novel mucosal vaccination approach for herpes simplex virus type-2
Biomedical Research Models, Inc.
September 14, 2017 - N°20170258894

The invention provides methods and kits for immunizing animals (e. G. Mammals) against viral antigens, including herpes-simplex virus type 2. The protective immune response elicited by the methods and kits of the invention is characterized by robust humoral, cellular, and mucosal immunity. In particular, the invention provides a heterologous immunization method comprising a priming dna vaccine encoding an antigen and a ...
Fusion protein comprising streptococcal antigen
Stichting Katholieke Universiteit
September 14, 2017 - N°20170258885

The disclosure provides a fusion protein comprising at least one antigenic fragment of a protein from a bacterium from genus streptococcus, as well as means for its expression. Outer membrane vesicles and vaccines comprising the fusion protein are also disclosed, as well as a method of vaccination using such vaccines.
Annexin a2 as immunological target
The Johns Hopkins University
September 14, 2017 - N°20170258881

Annexina2 (anxa2), a member of the annexin family of calcium-dependent, phospholipid binding proteins, is one of a panel of identified antigens recognized by the post-vaccination sera of patients who demonstrated prolonged disease-free survival following multiple vaccinations. Annexina2 is abundantly expressed in pancreatic adenocarcinomas and cell surface/membrane annexina2 increases with the progression from premalignant lesions to invasive pancreatic adenocarcinomas. The ...
Artificial nucleic acid molecules for improved protein or peptide expression
Curevac Ag
August 31, 2017 - N°20170247699

The invention relates to an artificial nucleic acid molecule comprising at least one 5′utr element which is derived from a top gene, at least one open reading frame, and preferably at least one histone stem-loop. Optionally the artificial nucleic acid molecule may further comprise, e. G. A poly(a)sequence, a poyladenylation signal, and/or a 3′utr. The ...
Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and ...
Ose Immunotherapeutics
August 31, 2017 - N°20170247464

The present invention pertains to the field of immunoterapy. More specifically, the present invention provides a method for differentiating myeloid-derived suppressor cells (mdsc) into non suppressive cells, by administering a compound blocking the interaction between sirpa and cd47 to a patient in need thereof in order to reduce mdsc-induced immunodepression and consequently allow appropriate immune responses in cancers, infectious diseases, ...
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Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease
The Regents Of The University Of Michigan
August 31, 2017 - N°20170246294

The present invention provides methods and compositions for the stimulation of immune responses and for treating or preventing allergic disease and responses and inflammatory disease and responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses that prevent or treat allergic disease by reducing allergic response. Compositions and methods ...
Synthetic long peptides (slp) for therapeutic vaccination against hepatitis b virus infection
Isa Pharmaceuticals B.v.
August 31, 2017 - N°20170246293

The present invention relates to the fields of medicine and immunology. In particular, it relates to novel peptides that may be used in the treatment and/or prevention of a hepatitis b viral infection and/or an hepatitis b related disease or condition.
Attenuated mannheimia haemolytica vaccines and methods of making and use
Merial Inc.
August 31, 2017 - N°20170246286

The present invention provides attenuated m. Haemolitica strains that elicit an immune response in animal against m. Haemolitica, compositions comprising said strains, methods of vaccination against m. Haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping ...
Vaccine compositions comprising tryptophan 2,3-dioxygenase or fragments thereof
Herlev Hospital
August 24, 2017 - N°20170239337

The invention relates to prophylaxis and therapy of cancer. In particular there is provided a protein tryptophan2,3-di-oxygenase (tdo) or peptide fragments here of that are capable of eliciting anti-cancer immune responses. Specifically, the invention relates to the use of tdo or peptides derived thereof or tdo specific t-cells for treatment of cancer. The invention thus relates to an anti-cancer ...
Rapid test to determine the necessity of revaccination
Kansas State University Research Foundation
August 17, 2017 - N°20170234876

Rapid, point of care semi-quantitative tests for viral or bacterial antibody titer, and methods and kits for carrying out the same. The test article comprises a first elongated solid support with a sample application region and a detection region. The detection region comprises immobilized antigen that specifically binds a minimum immunoprotective level of antibody to at least one pathogen of ...
Porcine circovirus type 2 (pcv2) subunit vaccine
Boehringer Ingelheim Vetmedica, Inc.
August 17, 2017 - N°20170232094

Vaccination methods to control pcv2 infection with different pcv2 subtypes are disclosed. Specifically, a pcv2 subtype b (pcv2b) orf2 proteins or immunogenic compositions comprising a pcv2b orf2 protein are used in a method for the treatment or prevention of an infection with pcv2 of a different subtype, the reduction, prevention or treatment of clinical signs caused by an ...
Antioxidants against oxidative stress during a stressor event
Merial Inc.
August 10, 2017 - N°20170224756

The present invention encompasses an effervescent grape extract plus selenium composition which improves stress response. The invention also encompasses methods of improving stress response, such as stress response to vaccination or weaning, by administration of the composition. The invention also encompasses methods of producing meat with improved quality by raising an animal on a diet supplemented with an effervescent grape ...
Compositions and methods for transient immune response modulation during vaccination
Duke University
August 03, 2017 - N°20170216426

In certain aspects the invention provides a selection of hiv-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogenic compositions and methods comprise at least one agent for transient immune response modulation during vaccination.