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Vaccination

Vaccination-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Recombinant hvt vectors expressing multiple antigens of avian pathogens and uses thereof
Merial, Inc.
June 14, 2018 - N°20180163230

The present invention provides recombinant herpesvirus of turkeys (hvt) vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant hvt vectors and polyvalent vaccines comprising the recombinant hvt vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant hvt vectors..
Sprayer technology
June 07, 2018 - N°20180154090

A spray apparatus adapted to be connected to a fluid supply such as a syringe to spray a predetermined pattern of spray fluid to a target area such as the tissues of an animal or human. The sprayer is particularly well suited to delivering a predetermined dose of a medicament, vaccine or the like to the nasal or other cavity ...
Tumors expressing igg1 fc induce robust cd8 t cell responses
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
June 07, 2018 - N°20180153978

A lymphoma cell line was engineered to express surface igg1 fc. These tumor cells were taken up rapidly by dcs, leading to enhanced cross-presentation of tumor-derived antigen to cd8 t cells.
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Artificial nucleic acid molecules
Curevac Ag
May 31, 2018 - N°20180148727

The invention relates to an artificial nucleic acid molecule comprising at least one open reading frame and at least one 3′-untranslated region element (3′-utr element) and/or at least one 5′-untranslated region element (5′-utr element), wherein the at least one 3′-utr element and/or the at least one 5′-utr element prolongs and/or increases ...
Immobilized poly(n)polymerase
Curevac Ag
May 24, 2018 - N°20180142275

The present invention relates to an immobilized poly(n)polymerase (pnp), methods of producing said pnp and uses thereof. Further disclosed is an enzyme reactor and kit comprising the pnp for producing polynucleotidylated ribonucleic acid poly(n)rna)molecules which are useful in gene therapy, immunotherapy, protein replacement therapy and/or vaccination..
Method for treating a patient in compliance with vaccination with eculizumab or an eculizumab variant
Alexion Pharmaceuticals, Inc.
May 24, 2018 - N°20180142010

The present disclosure relates to, inter alia, a method of treating a patient in need of treatment with a c5 inhibitor or a method for inhibiting formation of terminal complement in a patient, comprising administering an effective amount of a c5 inhibitor, such as eculizumab or an eculizumab variant, to a patient who is or will be in compliance with ...
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Enhancing the t-cell stimulatory capacity of human antigen presenting cells in vitro and in vivo ...
Vrije Universiteit Brussel
May 17, 2018 - N°20180133311

We provide new methods of in vitro or in vivo enhancing the t-cell stimulatory capacity of human dcs and the use thereof in cancer vaccination. The method includes the introduction of different molecular adjuvants to human dcs by contacting or modifying them with mrna or dna molecule(s) encoding cd40l, and cd70 or constitutively active tilr4 (catlr4)..
Early cancer detection and enhanced immunotherapy
May 17, 2018 - N°20180133298

A method of therapy for a tumor or other pathology by administering a combination of thermotherapy, immunotherapy, and vaccination optionally combined with gene delivery. The combination therapy beneficially treats the tumor and prevents tumor recurrence, either locally or at a different site, by boosting the patient's immune response both at the time or original therapy and/or for later therapy.
Measurement and comparison of immune diversity by high-throughput sequencing
The Board Of Trustees Of The Leland Stanford Junior University
May 10, 2018 - N°20180127827

High-throughput long read sequencing is used to perform immunogenomic characterization of expressed antibody repertoires in the context of vaccination. Informatic analysis allows global characterizations of isotype distributions, determination of the lineage structure of the repertoire and measure age and antigen related mutational activity.
Enrichment of cd16+ monocytes to improve dendritic cell vaccine quality
Health Research, Inc.
May 10, 2018 - N°20180127716

Compositions and methods are provided for converting the predominant circulating classical monocytes to a non-classical and/or intermediate monocyte phenotype through cytokine stimulation via, for example, macrophage colony-stimulating factor. Once cultured into dendritic cells, these non-classical and/or intermediate monocyte derived cells have increased costimulatory molecule expression, which leads to improved immune and clinical responses in cancer patients receiving dendritic ...
Antibody-vaccine engineered constructs (avec)
Phoenix Biomolecular Engineering Foundation
May 10, 2018 - N°20180126001

Hereby, we disclose and claim, the concept, designs, enabling technologies, and utility for therapy of patients suffering from cancer, of a novel class of biomolecularly engineered, synthetic molecules: antibody-vaccine engineered constructs (avec). They comprise the main functional domains (antibodies and vaccines) and the supporting domains (linkers and reporters).
Placental vaccination therapy for cancer
May 10, 2018 - N°20180125955

The present invention discloses methods of stimulating an immune response to cancer tissue and biological effectors used by tumors to defeat the host, through the immunization of a mammal using placental tissue, cells, molecules, and combinations thereof. In one embodiment, the invention provides the utilization of syngeneic, allogeneic, xenogeneic, and combinations thereof as immunizing sources..
Prime-boost regimens involving administration of at least one mrna construct
Curevac Ag
May 10, 2018 - N°20180125952

The present invention relates to prime-boost regimens that involve the administration of at least one mrna construct, such as the use of such constructs in “boost” administration subsequently to “prime” administration of certain other antigenic composition(s). Such inventive regimens may, in particular, be useful for the induction of an immune response ...
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Immunostimulatory compositions, particles, and uses related thereto
Emory University
May 03, 2018 - N°20180117145

In some embodiments, described herein is a method of tumor treatment or tumor vaccination. The method generally comprises applying to a human being in need thereof a tumor therapeutic composition or tumor vaccine defined herein.
Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
Pfizer Inc.
April 12, 2018 - N°20180099039

The present invention relates to new immunogenic compositions comprising conjugated streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a s.
Vaccine compositions and methods of use thereof
University Of Miami
April 12, 2018 - N°20180099032

Nanoparticle-based vaccines, compositions, kits and methods are used for the effective delivery of one or more antigens in vivo for vaccination and antibody (e.g., monoclonal antibody) production, and for the effective delivery of peptides, proteins, sirna, rna or dna to papcs or mhc class ii positive cells (e.g. Tumor cells).
Vaccination with anti-tick antigens to control multiple tick species and disease transmission in white-tailed deer ...
Louisiana State University
March 29, 2018 - N°20180085443

Compositions of either the rm86texas protein from a texas outbreak strain of the southern cattle fever tick, rhipicephalus microplus, or a nucleic acid construct incorporating a nucleic acid sequence encoding this rm86texas protein, are effective for eliciting a protective immune response in non-bovine animals. The rm86texas protein is immunogenic and can be administered as a protein vaccine, ...
Combination of vaccination and inhibition of mhc class i restricted antigen presentation
Curevac Ag
March 22, 2018 - N°20180078629

The present invention relates to a vaccine/inhibitor combination comprising as a vaccine at least one antigen and as an inhibitor at least one inhibitor of the major histocompatibility complex (mhc) class i restricted antigen presentation. The present invention furthermore relates to a method of vaccination of a mammal using the inventive vaccine/inhibitor combination.
In ovo delivery of probiotic cultures
Biogaia Ab
March 22, 2018 - N°20180078590

The present invention generally relates to a strain of lactobacillus probiotic bacteria and a poultry vaccine for use in the in ovo vaccination of poultry, wherein said strain and said vaccine are administered to an embryonated poultry egg. Compositions suitable for use in an in ovo vaccination protocol for poultry comprising a strain of lactobacillus probiotic bacteria and a vaccine ...
Method of detecting new immunogenic t cell epitopes and isolating new antigen-specific t cell receptors ...
Helmholtz Zentrum MÜnchen-deutsches Forschungszentrum FÜr Gesundheit Und
March 15, 2018 - N°20180073013

The present invention relates to the field of immunotherapy, in particular, to adoptive t cell therapy, t cell receptor (tcr) gene therapy and vaccination. The invention provides a method for preparing a nucleic acid encoding the tcr alpha chain construct (tra) and tcr beta chain construct (trb) of a tcr construct specific for an epitope from an antigen presented on ...
Silicon dioxide nanoparticles and the use thereof for vaccination
Merck Patent Gmbh
March 15, 2018 - N°20180071386

The invention relates to ultrasmall, monodisperse nanoparticles comprising silicon dioxide to the surface of which at least one antigen is attached. The nanoparticles can be used for the immunoprophylaxis or immunotherapy of cancer.
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