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Treprostinil

Treprostinil-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Inhalation formulations of treprostinil
United Therapeutics Corporation
February 15, 2018 - N°20180042876

The present invention describes novel methods for using treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), buerger's disease, raynaud's disease, raynaud's phenomenon and/or other conditions that cause such lesions. The invention also relates to kits for treatment ...
Treprostinil derivatives and compositions and uses thereof
Corsair Pharma, Inc.
January 18, 2018 - N°20180016222

The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
Preservative-free treprostinil formulations and methods and devices for use with same
Steadymed Ltd.
November 30, 2017 - N°20170340647

This invention provides for a unit dosage form of treprostinil at a dosage of between 0. 1 mg/ml and 25 mg/ml in a sterile fluid composition formulated for subcutaneous or intravenous injection, which composition does not comprise an antimicrobial preservative. Selectively activatable patch-pump assemblies comprising a sealed prefilled drug-reservoir containing the unit dosage form is described as are methods for reducing ...
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Process for the preparation of treprostinil
November 02, 2017 - N°20170313643

The invention provides a new process for the preparation of treprostinil of formula (i) and its salts using several new intermediates during the building of the ring system.
Treprostinil derivatives and compositions and uses thereof
October 19, 2017 - N°20170298001

The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
Salts of treprostinil
United Therapeutics Corporation
September 21, 2017 - N°20170267619

Provided are novel treprostinil salts as well as methods for making treprostinil salts.
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Process to prepare treprostinil, the active ingredient in remodulin®
United Therapeutics Corporation
June 29, 2017 - N°20170181990

This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
Synthesis of intermediates for producing prostacyclin derivatives
United Therapeutics Corporation
June 08, 2017 - N°20170158602

The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
Process to prepare treprostinil, the active ingredient in remodulin®
May 25, 2017 - N°20170144958

This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
Process to prepare treprostinil, the active ingredient in remodulin®
May 25, 2017 - N°20170144957

This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
Treprostinil formulations
United Therapeutics Corporation
April 06, 2017 - N°20170095432

Provided are ion complexes comprising treprostinil and an ion-exchange resin, pharmaceutical formulations based on such complexes, and methods of treating diseases and conditions using the ion complexes and pharmaceutical formulations.
Treprostinil derivative compounds and methods of using same
Corsair Pharma Inc.
March 23, 2017 - N°20170081303

Compounds represented by formulae i, ii, iii, and iv including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (ph) or pulmonary arterial hypertension (pah). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
Salts of treprostinil
United Therapeutics Corporation
March 16, 2017 - N°20170073295

Provided are novel treprostinil salts as well as methods for making treprostinil salts.
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Prostacyclin compounds, compositions and methods of use thereof
Insmed Incorporated
February 23, 2017 - N°20170049739

Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear c5-c18 alkyl, branched c5-c18 alkyl, linear c2-c18 alkenyl, branched c3-c18 alkenyl, aryl, aryl-c1-c18 alkyl or an amino acid or a peptide (e. G., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via ...
Treprostinil derivative compounds and methods of using same
Corsair Pharma, Inc.
December 22, 2016 - N°20160368889

Compounds represented by formulae i, ii, iii, and iv including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (ph) or pulmonary arterial hypertension (pah). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
Treprostinil derivatives and compositions and uses thereof
Corsair Pharma, Inc.
December 22, 2016 - N°20160368855

The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
Treprostinil derivatives and compositions and uses thereof
Corsair Pharma, Inc.
December 22, 2016 - N°20160368854

The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
Rapid-acting insulin compositions
Eli Lilly And Company
December 22, 2016 - N°20160367640

The invention is a composition of human insulin or insulin analog that includes treprostinil and that has faster pharmacokinetic action than commercial formulations of existing insulin analog products.
Prostacyclin compounds, compositions and methods of use thereof
Insmed Incorporated
November 03, 2016 - N°20160318844

Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear c2-c18 alkyl, branched c3-c18 alkyl, linear c2-c18 alkenyl, branched c3-c18 alkenyl, aryl, aryl-c1-c18 alkyl or an amino acid or a peptide (e. G., dipeptide, tripeptide, tetrapeptide) are described, for example, for administration via subcutaneous or ...
Prostacyclin compounds, compositions and methods of use thereof
Insmed Incorporated
September 08, 2016 - N°20160256425

Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear c5-c18 alkyl, branched c5-c18 alkyl, linear c2-c18 alkenyl, branched c3-c18 alkenyl, aryl, aryl-c1-c18 alkyl or an amino acid or a peptide (e. G., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via ...
Novel oral pharmaceutical compositions of treprostinil
Gavis Pharmaceuticals
August 25, 2016 - N°20160243064

Oral pharmaceutical compositions of treprostinil, a prodrug, or a pharmaceutically acceptable salt thereof are provided. The compositions possess absolute oral bioavailability of greater than 10% and achieve circulating concentrations when administered orally. Methods of treating prostacyclin responsive conditions including pulmonary arterial hypertension (pah) by administering such compositions also are provided.
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