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Treprostinil

Treprostinil-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Synthesis of intermediates for producing prostacyclin derivatives
United Therapeutics Corporation
June 08, 2017 - N°20170158602

The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
Process to prepare treprostinil, the active ingredient in remodulin®
United Therapeutics Corporation
May 25, 2017 - N°20170144958

This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
Process to prepare treprostinil, the active ingredient in remodulin®
United Therapeutics Corporation
May 25, 2017 - N°20170144957

This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
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Treprostinil derivative compounds and methods of using same
Corsair Pharma Inc.
March 23, 2017 - N°20170081303

Compounds represented by formulae i, ii, iii, and iv including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (ph) or pulmonary arterial hypertension (pah). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
Salts of treprostinil
United Therapeutics Corporation
March 16, 2017 - N°20170073295

Provided are novel treprostinil salts as well as methods for making treprostinil salts.
Rapid-acting insulin compositions
Eli Lilly And Company
March 02, 2017 - N°20170056478

The invention is a pharmaceutical composition of human insulin or insulin analog that includes citrate, treprostinil and stabilizing agents, that has faster pharmacokinetic and/or pharmacodynamic action than commercial formulations of existing insulin analog products and that is stable for commercial use.
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Treprostinil derivative compounds and methods of using same
Corsair Pharma, Inc.
December 22, 2016 - N°20160368889

Compounds represented by formulae i, ii, iii, and iv including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (ph) or pulmonary arterial hypertension (pah). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
Treprostinil derivatives and compositions and uses thereof
Corsair Pharma, Inc.
December 22, 2016 - N°20160368855

The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
Treprostinil derivatives and compositions and uses thereof
Corsair Pharma, Inc.
December 22, 2016 - N°20160368854

The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
Rapid-acting insulin compositions
Eli Lilly And Company
December 22, 2016 - N°20160367640

The invention is a composition of human insulin or insulin analog that includes treprostinil and that has faster pharmacokinetic action than commercial formulations of existing insulin analog products.
Prostacyclin compounds, compositions and methods of use thereof
Insmed Incorporated
November 03, 2016 - N°20160318844

Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear c2-c18 alkyl, branched c3-c18 alkyl, linear c2-c18 alkenyl, branched c3-c18 alkenyl, aryl, aryl-c1-c18 alkyl or an amino acid or a peptide (e. G., dipeptide, tripeptide, tetrapeptide) are described, for example, for administration via subcutaneous or ...
Prostacyclin compounds, compositions and methods of use thereof
Insmed Incorporated
September 08, 2016 - N°20160256425

Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear c5-c18 alkyl, branched c5-c18 alkyl, linear c2-c18 alkenyl, branched c3-c18 alkenyl, aryl, aryl-c1-c18 alkyl or an amino acid or a peptide (e. G., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via ...
Novel oral pharmaceutical compositions of treprostinil
Gavis Pharmaceuticals
August 25, 2016 - N°20160243064

Oral pharmaceutical compositions of treprostinil, a prodrug, or a pharmaceutically acceptable salt thereof are provided. The compositions possess absolute oral bioavailability of greater than 10% and achieve circulating concentrations when administered orally. Methods of treating prostacyclin responsive conditions including pulmonary arterial hypertension (pah) by administering such compositions also are provided.
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Treprostinil administration by inhalation
United Therapeutics Corporation
May 26, 2016 - N°20160143868

Treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients. Also disclosed are kits that include a metered dose inhaler containing a pharmaceutical formulation containing treprostinil.
Rapid-acting insulin compositions
Eli Lilly And Company
May 12, 2016 - N°20160129087

The invention is a composition of human insulin or insulin analog that includes treprostinil and that has faster pharmacokinetic action than commercial formulations of existing insulin analog products.
Synthesis of intermediates for producing prostacyclin derivatives
Eli Lilly And Company
April 21, 2016 - N°20160107973

The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
Synthesis of intermediate for treprostinil production
United Therapeutics Corporation
March 10, 2016 - N°20160068461

The compound according to formula i is an intermediate in the synthesis of prostacylin analogs. The present invention provides an efficient method for synthesizing a formula i compound.
Amorphous solid dispersion of treprostinil diethanolamine
Dr. Reddy's Laboratories Limited
February 18, 2016 - N°20160045470

The present application relates to the amorphous solid dispersion of treprostinil diethanolamine salt and the process for its preparation.
Process to prepare treprostinil, the active ingredient in remodulin®
United Therapeutics Corporation
December 31, 2015 - N°20150376106

This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
Prostacylin compositions and methods for using the same
Insmed Incorpration
November 19, 2015 - N°20150328232

The present invention relates to pharmaceutical compositions comprising a prostacyclin, a cationic compound, and a surfactant. Particulate compositions, including liposomal, solid nanoparticulate prostacyclin compositions, including treprostinil formulations comprising cationic compound and the surfactant are also described. The present invention also relates to a system comprising the pharmaceutical composition and an inhalation device. Methods for treating pulmonary hypertension and portopulmonary hypertension ...
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