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Treprostinil

Treprostinil-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Treprostinil derivative compounds and methods of using same
Corsair Pharma Inc.
June 14, 2018 - N°20180162829

Compounds represented by formulae i, ii, iii, and iv including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (ph) or pulmonary arterial hypertension (pah).
Treprostinil prodrugs
United Therapeutics Corporation
June 07, 2018 - N°20180153847

Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.. .
Rapid-acting insulin compositions
Eli Lilly And Company
May 24, 2018 - N°20180140676

The invention is a pharmaceutical composition of human insulin or insulin analog that includes citrate, treprostinil and stabilizing agents, that has faster pharmacokinetic and/or pharmacodynamic action than commercial formulations of existing insulin analog products and that is stable for commercial use.. .
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Solid forms of treprostinil
United Therapeutics Corporation
March 15, 2018 - N°20180072649

There is provided individual polymorphic forms of treprostinil and pharmaceutical formulations comprising the same, methods of making and using the same.. .
Inhalation formulations of treprostinil
United Therapeutics Corporation
February 15, 2018 - N°20180042876

The present invention describes novel methods for using treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), buerger's disease, raynaud's disease, raynaud's phenomenon and/or other conditions that cause such lesions. The invention also relates to kits for treatment ...
Treprostinil derivatives and compositions and uses thereof
Corsair Pharma, Inc.
January 18, 2018 - N°20180016222

The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension..
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Treprostinil Patent Applications
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Methods of manufacturing treprostinil and treprostinil derivative prodrugs
Insmed Incorporated
November 09, 2017 - N°20170320813

Methods for making prodrugs of trepreostinil and treprostinil derivatives are provided. Specifically, methods are provided herein for producing prostacyclin compounds comprising treprostinil covalently linked to a linear c5-c18 alkyl, branched c5-c18 alkyl, linear c2-c18 alkenyl, branched c3-c18 alkenyl, aryl, aryl-c1-c18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide).
Process for the preparation of treprostinil
November 02, 2017 - N°20170313643

The invention provides a new process for the preparation of treprostinil of formula (i) and its salts using several new intermediates during the building of the ring system.. .
Treprostinil derivatives and compositions and uses thereof
October 19, 2017 - N°20170298001

The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension..
Salts of treprostinil
United Therapeutics Corporation
September 21, 2017 - N°20170267619

Provided are novel treprostinil salts as well as methods for making treprostinil salts.. .
Synthesis of intermediate for treprostinil production
United Therapeutics Corporation
July 13, 2017 - N°20170197898

The compound according to formula i is an intermediate in the synthesis of prostacylin analogs. The present invention provides an efficient method for synthesizing a formula i compound..
Process to prepare treprostinil, the active ingredient in remodulin®
United Therapeutics Corporation
June 29, 2017 - N°20170181990

This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil..
Synthesis of intermediates for producing prostacyclin derivatives
United Therapeutics Corporation
June 08, 2017 - N°20170158602

The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.. .
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Treprostinil Patent Applications
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Process to prepare treprostinil, the active ingredient in remodulin®
May 25, 2017 - N°20170144957

This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil..
Treprostinil formulations
United Therapeutics Corporation
April 06, 2017 - N°20170095432

Provided are ion complexes comprising treprostinil and an ion-exchange resin, pharmaceutical formulations based on such complexes, and methods of treating diseases and conditions using the ion complexes and pharmaceutical formulations.. .
Treprostinil derivative compounds and methods of using same
Corsair Pharma Inc.
March 23, 2017 - N°20170081303

Compounds represented by formulae i, ii, iii, and iv including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (ph) or pulmonary arterial hypertension (pah).
Salts of treprostinil
United Therapeutics Corporation
March 16, 2017 - N°20170073295

Provided are novel treprostinil salts as well as methods for making treprostinil salts.. .
Rapid-acting insulin compositions
Eli Lilly And Company
March 02, 2017 - N°20170056478

The invention is a pharmaceutical composition of human insulin or insulin analog that includes citrate, treprostinil and stabilizing agents, that has faster pharmacokinetic and/or pharmacodynamic action than commercial formulations of existing insulin analog products and that is stable for commercial use.. .
Prostacyclin compounds, compositions and methods of use thereof
Insmed Incorporated
February 23, 2017 - N°20170049739

Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear c5-c18 alkyl, branched c5-c18 alkyl, linear c2-c18 alkenyl, branched c3-c18 alkenyl, aryl, aryl-c1-c18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described.
Treprostinil derivative compounds and methods of using same
Corsair Pharma, Inc.
December 22, 2016 - N°20160368889

Compounds represented by formulae i, ii, iii, and iv including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (ph) or pulmonary arterial hypertension (pah).
Treprostinil derivatives and compositions and uses thereof
Corsair Pharma, Inc.
December 22, 2016 - N°20160368855

The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension..
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