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Treprostinil patents

      

This page is updated frequently with new Treprostinil-related patent applications.




 Treprostinil derivative compounds and methods of using same patent thumbnailTreprostinil derivative compounds and methods of using same
Compounds represented by formulae i, ii, iii, and iv including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (ph) or pulmonary arterial hypertension (pah).
Corsair Pharma, Inc.


 Treprostinil derivatives and compositions and uses thereof patent thumbnailTreprostinil derivatives and compositions and uses thereof
The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension..
Corsair Pharma, Inc.


 Treprostinil derivatives and compositions and uses thereof patent thumbnailTreprostinil derivatives and compositions and uses thereof
The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension..
Corsair Pharma, Inc.


 Rapid-acting insulin compositions patent thumbnailRapid-acting insulin compositions
The invention is a composition of human insulin or insulin analog that includes treprostinil and that has faster pharmacokinetic action than commercial formulations of existing insulin analog products.. .
Eli Lilly And Company


 Prostacyclin compounds, compositions and methods of use thereof patent thumbnailProstacyclin compounds, compositions and methods of use thereof
Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear c2-c18 alkyl, branched c3-c18 alkyl, linear c2-c18 alkenyl, branched c3-c18 alkenyl, aryl, aryl-c1-c18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described, for example, for administration via subcutaneous or intravenous infusion to a patient in need of pulmonary hypertension treatment.
Insmed Incorporated


 Prostacyclin compounds, compositions and methods of use thereof patent thumbnailProstacyclin compounds, compositions and methods of use thereof
Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear c5-c18 alkyl, branched c5-c18 alkyl, linear c2-c18 alkenyl, branched c3-c18 alkenyl, aryl, aryl-c1-c18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described.
Insmed Incorporated


 Novel oral pharmaceutical compositions of treprostinil patent thumbnailNovel oral pharmaceutical compositions of treprostinil
Oral pharmaceutical compositions of treprostinil, a prodrug, or a pharmaceutically acceptable salt thereof are provided. The compositions possess absolute oral bioavailability of greater than 10% and achieve circulating concentrations when administered orally.
Gavis Pharmaceuticals


 Device for treating a cutaneous ulcer patent thumbnailDevice for treating a cutaneous ulcer
A dc generator, the terminals of which are connected to the electrodes, the cathode and the anode respectively forming the active electrode and the passive electrode for iontophoresis, so as to cause treprostinil to migrate by cathodal iontophoresis into the region to be treated.. .

 Novel intermediate for synthesizing treprostinil diethanolamine and  preparing the same patent thumbnailNovel intermediate for synthesizing treprostinil diethanolamine and preparing the same
Wherein r1 and r2 are described in the description.. .

 Treprostinil administration by inhalation patent thumbnailTreprostinil administration by inhalation
treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients.
United Therapeutics Corporation


Rapid-acting insulin compositions

The invention is a composition of human insulin or insulin analog that includes treprostinil and that has faster pharmacokinetic action than commercial formulations of existing insulin analog products.. .
Eli Lilly And Company

Synthesis of intermediates for producing prostacyclin derivatives

The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.. .

Synthesis of intermediate for treprostinil production

The compound according to formula i is an intermediate in the synthesis of prostacylin analogs. The present invention provides an efficient method for synthesizing a formula i compound..
United Therapeutics Corporation

Amorphous solid dispersion of treprostinil diethanolamine

The present application relates to the amorphous solid dispersion of treprostinil diethanolamine salt and the process for its preparation.. .
Dr. Reddy's Laboratories Limited

Process to prepare treprostinil, the active ingredient in remodulin®

This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil..
United Therapeutics Corporation

Prostacylin compositions and methods for using the same

The present invention relates to pharmaceutical compositions comprising a prostacyclin, a cationic compound, and a surfactant. Particulate compositions, including liposomal, solid nanoparticulate prostacyclin compositions, including treprostinil formulations comprising cationic compound and the surfactant are also described.
Insmed Incorpration

Process to prepare treprostinil, the active ingredient in remodulin®

This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil..
United Therapeutics Corporation

Salts of treprostinil

Provided are novel treprostinil salts as well as methods for making treprostinil salts.. .
United Therapeutics Corporation

Prostacyclin compounds, compositions and methods of use thereof

Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear c5-c18 alkyl, branched c5-c18 alkyl, linear c2-c18 alkenyl, branched c3-c18 alkenyl, aryl, aryl-c1-c18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described.
Insmed Incorporated

Treprostinil derivative compounds and methods of using same

Compounds represented by formulae i, ii, iii, and iv including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (ph) or pulmonary arterial hypertension (pah).
Corsair Pharma, Inc.

Inhalation formulations of treprostinil

The present invention describes novel methods for using treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), buerger's disease, raynaud's disease, raynaud's phenomenon and/or other conditions that cause such lesions. The invention also relates to kits for treatment and/or prevention of ischemic lesions, comprising an effective amount of treprostinil or its derivative, or a pharmaceutically acceptable salt thereof..
United Therapeutics Corporation

Prostacyclin compounds, compositions and methods of use thereof

Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear c5-c18 alkyl, branched c5-c18 alkyl, linear c2-c18 alkenyl, branched c3-c18 alkenyl, aryl, aryl-c1-c18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described.
Insmed Incorporated

Improved process for the preparation of treprostinil and derivatives thereof

A method for the preparation of treprostinil and its derivatives is described. In contrast to prior art, this method utilizes an easily scalable enzymatic resolution of a key intermediate for making these compounds.
Scipharm Sàrl

Treprostinil production

The present invention is directed to a novel method for preparing a synthetic intermediates for treprostinil. Also described are methods of preparing treprostinil comprising utilizing novel intermediates described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil..
United Therapeutics Corporation

Carrier-linked treprostinil prodrugs

The present invention relates to prodrugs or a pharmaceutically acceptable salt thereof comprising a covalent treprostinil carrier conjugate as well as pharmaceutical composition comprising said compounds. The compounds may be used as medicaments, especially for diseases or disorders which can be treated by treprostinil, such as pulmonary arterial hypertension (pah)..

Stable solutions of treprostinil

An improved method for administering treprostinil or a salt is described that allows for use of the diluted solution prior to administration for a longer period of time to avoid wasted medication.. .



Treprostinil topics:
  • Treprostinil
  • Prostacyclin
  • Atherogenesis
  • Platelet Aggregation
  • Lung Disease
  • Vasodilation
  • Cell Proliferation
  • Proliferation
  • Angiogenesis
  • Benzaldehyde
  • Pharmaceutically Acceptable Salt
  • Pulmonary Fibrosis
  • Interstitial
  • Metered Dose Inhaler


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    This listing is a sample listing of patent applications related to Treprostinil for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Treprostinil with additional patents listed. Browse our RSS directory or Search for other possible listings.


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