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Transplant

Transplant-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Amniotic fluid-derived preparation with a standardized biologic activity
Applied Biologics, Llc
January 18, 2018 - N°20180015128

This invention relates to preparations derived from amniotic fluid, and more specifically, to an amniotic fluid preparation with specific standardized measure of the biologic activity of a component of the preparation, such as a constituent protein, for use in clinical and research applications. The amniotic fluid preparation with standardized biologic activity resolves problems of establishing efficacy, safety, and reproducibility in ...
Cells genetically modified to comprise pancreatic islet glucokinase and uses thereof
University Of Technology, Sydney
January 11, 2018 - N°20180010104

The present invention relates generally to a population of cells genetically modified to produce insulin in a glucose responsive manner and uses thereof. More particularly, the present invention relates to a population of cells genetically modified to produce insulin in response to physiologically relevant levels of glucose and uses thereof. The cells of the present invention are useful in a ...
Thin film cell encapsulation devices
The Regents Of The University Of California
January 11, 2018 - N°20180010089

Thin film devices, e. G., multilayer thin film devices, that encapsulate cells for transplantation into a subject are provided. Also provided are methods of using and methods of preparing the subject devices. The thin film devices include a first porous polymer layer and a second porous polymer layer that define a lumen therebetween and encapsulate a population of cells within ...
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Transplant Patent Applications
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inventor
  • 296+ full patent PDF documents of Transplant-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
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Composition for use in increasing engraftment efficacy of haematopoetic stem cells after transplantation
Scipharm SÀrl
January 11, 2018 - N°20180008606

The present invention provides the new use of composition comprising at least one inhibitor of dipeptidyl peptidase iv (dpp-iv) for increasing migration and homing of haematopoetic progenitor cells in stem cell transplanted recipients, wherein said haematopoetic stem and/or progenitor cells had been treated in vitro with an engraftment enhancing compound, specifically with a prostacyclin analogue and a camp enhancer ...
Device for attaching a ligament transplant
Fh Orthopedics
January 11, 2018 - N°20180008398

This fastening device comprises a bearing member intended to bear against the outer cortex of a bone and provided with a passage orifice, and a flexible connecting member configured to connect the ligament transplant to the bearing member. The connecting member comprises a tubular portion configured to extend through the passage orifice and can be deformed between a first state ...
Non-invasive method and system for assessing survival of transplanted flap
Chimei Medical Center
January 11, 2018 - N°20180008164

A non-invasive method and system for assessing the survival of a transplanted flap involve the following steps. A control unit instructs a variable-frequency current generator circuit to generate a constant current at a fixed frequency and pass the constant current through a detection electrode. The detection electrode detects a bioelectrical impedance of the skin to which the flap has been ...
Transplant Patent Pack
Download 296+ patent application PDFs
Transplant Patent Applications
Download 296+ Transplant-related PDFs
For professional research & prior art discovery
inventor
  • 296+ full patent PDF documents of Transplant-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
January 04, 2018 - N°20180007043

Useful in the prophylaxis and/or treatment of inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant rejection, diseases involving degradation and/or disruption of cartilage homeostasis, congenital cartilage malformations, and/or diseases associated with hypersecretion of il6 or interferons.
Therapeutic use for alpha1 proteinase inhibitor in hematopoiesis
The Institute For Human Genetics And Biochemistry
January 04, 2018 - N°20180003699

A previously unrecognized fundamental property of α1pi is to regulate the phenotypic composition of circulating and tissue-associated cells derived from hematopoietic stem cells. The present invention comprises screening for various unmodified and modified α1pi's which are useful in the treatment of abnormalities in the number of cells of myeloid or lymphoid lineage that are associated with ...
Amniotic fluid-derived preparations
Applied Biologics, Llc
January 04, 2018 - N°20180000869

The invention relates to an amniotic fluid-derived preparation. The amniotic fluid-derived preparation leverages cellular and non-cellular constituent components of amniotic fluid for use across a broad range of therapeutic applications, including use by physicians and other healthcare providers in the surgical and minimally invasive medical therapy of a wide range of injuries and disease processes. The amniotic fluid-derived preparation concentrates ...
Disease prevention and alleviation by human myoblast transplantation
January 04, 2018 - N°20180000867

Methods and materials are described for human genome prophylaxis and therapy of diseases using myoblast transfer. These methods result in gene transcript changes in multiple pathways. Linking the myoblast transfer technology development from dmd, cardiomyopathy, and type-ii diabetes, the myoblast transfer demonstrably mediates its effect through transfer of the normal myoblast nuclei that supply the complete human genome, in addition ...
Systems andmethods to improve organor tissue function andorganor tissue transplant longevity
Proterris, Inc.
January 04, 2018 - N°20180000859

The present invention provides for systems and methods for inhaled co therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological ...
Novel compound useful for the treatment of degenerative and inflammatory diseases
Galapagos Nv
January 04, 2018 - N°20180000831

A novel compound able to inhibit jak is disclosed, this compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/...
Methods for treatment of alport syndrome
Regulus Therapeutics Inc.
December 28, 2017 - N°20170369879

Provided herein are methods for the treatment of alport syndrome, using modified oligonucleotides targeted to mir-21. In certain embodiments, a modified oligonucleotide targeted to mir-21 improves kidney function and/or reduces fibrosis in subjects having alport syndrome. In certain embodiments, administration of a modified oligonucleotide targeted to mir-21 delays the onset of end-stage renal disease in a subject having alport ...
Transplant Patent Pack
Download 296+ patent application PDFs
Transplant Patent Applications
Download 296+ Transplant-related PDFs
For professional research & prior art discovery
inventor
  • 296+ full patent PDF documents of Transplant-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Direct conversion of cells to cells of other lineages
The Board Of Trustees Of The Leland Stanford Junior University
December 28, 2017 - N°20170369840

Methods, compositions and kits for producing functional neurons, astroctyes, oligodendrocytes and progenitor cells thereof are provided. These methods, compositions and kits find use in producing neurons, astrocytes, oligodendrocytes, and progenitor cells thereof for transplantation, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example for use in treating human disorders of the cns. Also ...
Interferon alpha antibodies and their uses
E. R. Squibb & Sons, L.l.c.
December 28, 2017 - N°20170369568

The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (ifn) alpha subtypes but do not substantially inhibit the biological activity of ifn alpha 21 or the biological activity of either ifn beta or ifn omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also ...
Methods and compositions for inhibiting polyomavirus-associated pathology
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services
December 28, 2017 - N°20170368163

Disclosed herein are methods of eliciting an immune response against a polyomavirus (for example, bkv serotype i (bkv-i), bkv serotype ii (bkv-ii), bkv serotype iii (bkv-iii) and/or bkv serotype iv (bkv-iv)) and methods of treating or inhibiting polyomavirus-associated pathology (such as polyomavirus-associated nephropathy, bkv-associated hemorrhagic cystitis, or jc virus-associated progressive multifocal leukoencephalopathy; pml). Further disclosed are immunogenic compositions of ...
Tissue transplantation involving, and tissues modified by decellularization and recellularization of donor tissues for minimized ...
December 28, 2017 - N°20170368141

The method of tissue transplantation involving recellularizing of a donor organ with the utilization of the recipient's cytokines collected from the recipient's blood plasma at less than systemic pressure, and at the temperature greater than freezing and less than normal systemic temperature of the recipient's blood. Specifically, a method of harvesting a platelet-derived growth factors from platelet rich plasma (prp), ...
Induction of tolerance in lung allograft transplantation
Washington University
December 28, 2017 - N°20170368104

The present disclosure relates to methods of inducing tolerance to lung allograft transplantation. These methods comprise increasing suppressor cd8+ t cells and/or suppressing deleterious cd8+ and cd4+ t cells.
Methods of measuring potential for therapeutic potency and defining dosages for autologous cell therapies
Biocardia, Inc.
December 21, 2017 - N°20170363623

Autologous bone marrow cells (bmc) are transplanted to a heterologous site in a patient after a sample of the patient's bmc has been tested and found to have a phenotypic profile which meets minimum criteria for transplantation. The phenotypic profile may be obtained by screening a sample of bone marrow cells (bmc) from the patient for the phenotypic profile, such ...
Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions
The General Hospital Corporation
December 21, 2017 - N°20170362266

The present application provides methods of functionalizing an organ or tissue of a mammal by administering a nutrient (e. G., peracetylated n-azido galactosamine ac4galnaz) to the mammal or by culturing an organ or tissue in a bioreactor containing such nutrient. The present application also provides methods of selectively functionalizing extracellular matrix (ecm) of an organ or tissue of a ...
4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors
Celgene Corporation
December 21, 2017 - N°20170362240

Compounds of formula i: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which r1, r2, r3 and r4 have the meanings given in the specification, are inhibitors of one or more jak kinases and are useful in the treatment of jak kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, ...
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