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Transplant patents

      

This page is updated frequently with new Transplant-related patent applications.




 Combined organ and hematopoietic cells for transplantation tolerance of hla mismatched grafts patent thumbnailCombined organ and hematopoietic cells for transplantation tolerance of hla mismatched grafts
Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to an hla mismatched recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance..
The Board Of Trustees Of The Leland Stanford Junior University


 Compositions enriched for hox11+ stem cells and methods of preparing the same patent thumbnailCompositions enriched for hox11+ stem cells and methods of preparing the same
The invention features enriched hox11+ stem cell compositions and methods of preparing and using the same. In particular, the enriched hox11+ stem cell composition can be used for treating medical conditions, diseases, or disorders, for transplantation and transplantation therapy, and for cellular, tissue, or organ repair or regeneration..
The General Hospital Corporation


 Compositions and methods relating to treatment of infection patent thumbnailCompositions and methods relating to treatment of infection
Microbial keratitis is a sight threatening disorder and infections result in ocular pain, stromal destruction, corneal thinning and/or perforation, leading to vision loss, if untreated and the need for transplantation. Methods of treating bacterial infection of the cornea prophylactically or therapeutically in a subject, are provided according to aspects of the present invention which include administering an effective dose of glycyrrhizin, or a pharmaceutically acceptable salt, hydrate, solvate, ester, amide, isomer or derivative thereof characterized by anti-bacterial activity, to the subject..
Wayne State University


 Modulated immunodominance therapy patent thumbnailModulated immunodominance therapy
The invention involves generating a t cell response to subdominant antigens and using the cells to therapeutically change the cellular homeostasis and nature of the immune response. In a preferred embodiment, the cells are generated outside of the patient avoiding the influence of the patient's immunologic milieu.
Geneius Biotechnology, Inc.


 Fluid pumping and bioreactor system patent thumbnailFluid pumping and bioreactor system
A fluid pumping and bioreactor system including at least two cassettes, at least one storage reservoir, at least one bioreactor, at least one manifold including valve modules, and tubing to connect the cassettes to the storage reservoir and the bioreactor. The cassettes can include pumps, valves, and fluid conduits and can be communicatively connected to the at least one manifold.
Deka Products Limited Partnership


 Fusion proteins of collagen-binding domain and parathyroid hormone patent thumbnailFusion proteins of collagen-binding domain and parathyroid hormone
Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (pth) and parathyroid hormone related peptide (pthrp) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy.
The Board Of Trustees Of The University Of Arkansas


 Cell structure and  producing cell structure patent thumbnailCell structure and producing cell structure
An object of the present invention is to provide a cell structure which does not contain glutaraldehyde and can form blood vessels after transplantation, and a method for producing the above-described cell structure. According to the present invention, there is provided a cell structure which contains a biocompatible macromolecular block and at least one kind of cell and has voids and in which a plurality of the biocompatible macromolecular blocks are arranged in gaps between a plurality of the cells, in which a ratio of the volume of the biocompatible macromolecular blocks with respect to the volume of the cell structure is 10% to 30%, a ratio of the volume of the cells with respect to the volume of the cell structure is 20% to 50%, and a ratio of the volume of the voids with respect to the volume of the cell structure is 35% to 60%..
Fujifilm Corporation


 Therapeutic encapsulated mesenchymal stromal cells patent thumbnailTherapeutic encapsulated mesenchymal stromal cells
This application discloses a micro-encapsulation system for immobilizing mesenchymal stromal cells (mscs) while sustaining the molecular communication. Thus, the invention provides the use of encapsulated mesenchymal stromal cells in the cellular transplantation therapies.
Rutgers, The State University Of New Jersey


 Plant-transplanting device patent thumbnailPlant-transplanting device
There is provided a plant-transplanting device that, with a simple structure and at a low cost, realizes speedy and stable transplantation, prevents damage to a plant, and is easily automated. A plant-transplanting device 100 that transplants a seedbed b from a plant holder 110 to a cultivation pallet 120 includes a holder retaining mechanism 130, a pallet retaining mechanism 140 for retaining the cultivation pallet 120 below a holder retaining position of the holder retaining mechanism 130, and a lowering mechanism 150 for lowering the seedbed b retained by a holder seedbed retaining part 111 downward and inserting the seedbed b into a pallet seedbed retaining part 121..
Tsubakimoto Chain Co.


 Dna aptamers specific to cd200r1 and their therapeutic uses patent thumbnailDna aptamers specific to cd200r1 and their therapeutic uses
Disclosed are short dna aptamers that selectively recognize cd200r1, a protein expressed on the surface of myeloid and lymphoid cells that delivers immune inhibitory signals to modulate inflammation when engaged with its ligand, cd200. Also disclosed is the use of said aptamers as therapeutic agents, for the purpose of decreasing inflammatory response; treatment of spinal cord injury; treatment of an immune related disease such as arthritis, allergy, infection; as a course of treatment during or after transplantation; or for treatment of an autoimmune disorders such as systemic lupus erythematosus, parkinson's disease, or multiple sclerosis..
D5pharma Inc.


Method for detecting antibody-secreting b cells specific for hla

The invention relates methods for detecting antibody-secreting b-cells specific for at least an hla in a subject. The invention also relates to kits for developing said methods and to the use of said methods for determining the risk of a subject having humoral rejection against an allogeneic transplant, for determining the risk of a subject of suffering endarteritis associated with post-transplant humoral rejection after allogeneic organ or tissue transplant, for selecting a subject to receive a transplant, and for determining the presence of humoral sensitization against hla..
Institut D'investigació Biomèdica De Bellvitge (idibell)

Allograft rejection test

Systems and methods apply antibody labeling to quantify perforin-positive lymphocytes per unit area in an allograft biopsy, for detection and characterization of transplant rejection. An example technique includes staining the allograft biopsy to visualize lymphocytes, applying labeled anti-perforin antibodies to the allograft biopsy, visualizing the labeled anti-perforin antibodies to show perforin-positive lymphocytes, quantifying the perforin-positive lymphocytes to determine a count of the perforin-positive lymphocytes per unit area, and classifying a rejection parameter of the allograft based on the count.

Methods of predicting acute rejection outcomes

A method for assessing risk of losing a transplanted organ by a patient having an episode of acute rejection of the transplanted organ is described. The method includes obtaining from the patient a cell sample from the transplanted organ or peripheral blood, determining a level of foxp3 in the cell sample, and correlating the level with the risk of loss of the transplanted organ, wherein, compared to a control level, a significantly greater level of foxp3 in the cell sample from the transplanted organ or a significantly lower level of foxp3 in the cell sample from the peripheral blood correlates with a decreased risk of loss of the transplanted organ..
Cornell Research Foundation, Inc.

Adeno-associated virus vector variants for high efficiency genome editing and methods thereof

Adeno-associated virus (aav) clade f vectors or aav vector variants (relative to aav9) for precise editing of the genome of a cell and methods and kits thereof are provided. Targeted genome editing using the aav clade f vectors or aav vector variants provided herein occurred at frequencies that were shown to be 1,000 to 100,000 fold more efficient than has previously been reported.
City Of Hope

Methods and compositions for preventing ischemia reperfusion injury in organs

The invention, in some embodiments, relates to compounds and methods for the prevention of ischemia reperfusion injury (iri) in organs, and in particular to iri in organs aged 35 years and older. Specific uses include prevention of iri in native organs in vivo, in reimplantations and in transplantations of donor organs aged 35 years and older.
Quark Pharmaceuticals, Inc.

Materials and methods for expansion of stem cells

The subject invention concerns novel and translatable materials and methods for expansion of stem cells, such as mesenchymal stem cells (msc), that significantly improve translational success of the cells in the treatment of various conditions, such as stroke. The subject invention utilizes cell self-aggregation as a non-genetic means to enhance their therapeutic potency in a microcarrier bioreactor.
Florida State University Research Foundation, Inc.

Novel compounds as diacylglycerol acyltransferase inhibitors

This invention relates to novel compounds which are inhibitors of acyl coenzyme a: diacylglycerol acyltransferase 1 (dgat-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination with weight management therapies or other triglyceride lowering therapy for the prevention or treatment of diseases related to dgat-1 dysfunction or where modulation of dgat-1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, genetic (type 1, type 5 hyperlipidemia) and acquired forms of hypertriglyceridemia or hyperlipoproteinemia-related disorders, caused by but not limited to lipodystrophy, hypothyroidism, medications (beta blockers, thiazides, estrogen, glucocorticoids, transplant) and other factors (pregnancy, alcohol intake), hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, cardiovascular outcomes, angina, excess hair growth (including syndromes associated with hirsutism), nephrotic syndrome, fibrosis such as myocardial, renal and liver fibrosis, hepatitis c virus infection and acne or other skin disorders.. .
Glaxosmithkline Llc

Compositions and methods for modulating the immune system

A novel class of embryo derived peptides are described (preimplantation factor) that were generated synthetically and were tested on peripheral blood immune cells and shown to block activated but not basal immunity, inhibiting cell proliferation and creating a th2 type cytokine bias, in addition pif enhance endometrial receptivity by increasing adhesion molecules expression. Pif biological activity appears to be exerted by specific binding to inducible receptors present on the several white cell lineages.
Bioincept, Llc

Methods and compositions for non-cytotoxic stem cell transplantation

Certain embodiments are directed to compositions and methods for non-cytotoxic hematopoietic stem cell transplantation.. .
The Board Of Regent Of The University Of Texas System

Defibrotide for use in prophylaxis and/or treatment of graft versus host disease (gvhd)

Defibrotide for use in prophylaxis and/or treatment of graft versus host disease (gvhd) in humans is disclosed, preferably in hematopoietic stem cell transplantation (hsct), more preferably allogeneic hematopoietic stem cell transplantation. Graft versus host disease of the invention (gvhd) can be acute agvhd and/or chronic cgvhd, preferably acute..
Gentium S.r.l.

Methods of managing graft versus host disease (gvhd) using indole carboxyaldehydes or derivatives thereof

In certain embodiments, this disclosure relates to methods of treating or preventing hvgd comprising administering an effective amount of indole-2-carboxyaldehyde, indole-3-carboxyaldehyde, or derivative to a subject in need thereof. In certain embodiments, this disclosure relates to methods of treating a subject with a hematological malignancy or other cancer comprising transplanting allogenic bone marrow or stem cells in combination with administering an effective amount of an indole-2-carboxyaldehyde, indole-3-carboxyaldehyde, or derivative thereof to a subject in need thereof..
Emory University

Skin tensioning devices and methods of their use

Devices and methods for applying tension to an area of skin during various cosmetic or dermatological procedures, in particular for follicular unit removal and/or implantation in a hair transplantation procedure, are provided. The systems and methods utilize a segmented structure configured to conform to the body surface of various sizes, shapes and/or textures, thus allowing for customization in order to fit a variety of persons.
Restoration Robotics, Inc.

Methods of obtaining pancreatic endocrine cells

The present invention relates to methods of producing pancreatic endocrine cells and uses of the cells obtained using the methods. The method utilises inhibitors or combinations of factors to provide increased quantities of endocrine material, for example for transplantation purposes..
Lothian Health Board

Bioengineered allogeneic valve

The present disclosure relates to methods for recellularization of valves in valve-bearing veins. This method is useful for producing an allogeneic venous valve, wherein a donor valve-bearing vein is decellularized and then recelluiarized using whole blood or bone marrow stem cells.
Novahep Ab

Methods and systems for directing movement of a tool in hair transplantation procedures

Methods and systems are provided useful in various procedures, including hair harvesting and implantation, and further including computer-implemented and/or robotic hair transplantation. Methodologies are provided which enable selection of follicular unit harvesting or implanting sites within the same row in a direction of travel of the tool, or by incrementing to another row.
Restoration Robotics, Inc.

Fluid for suspended animation

A method to increase the time a donated organ will remain viable prior to transplantation, where the method includes infusing into a human patient declared brain dead, using a first intravenous line, a fluorocarbon fluid comprising a chain length from 1 to about 20 carbon atoms, and optionally synchronously with said infusing, exsanguinating said patient using a second intravenous line.. .
Nuvox Pharma Llc

Selective immunodepletion of endogenous stem cell niche for engraftment

The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of gvhd or graft rejection. Aspects of the present invention are based on the discovery that the depletion of the endogenous stem cell niche facilitates efficient engraftment of stem cells into that niche.
The Board Of Trustees Of The Leland Stanford Junior University

Microneedle based cell delivery

The invention relates to a device for use in skin improvement or repair, including promoting hair growth, comprising the use of microneedles for the transplantation of cells and a method employing the use of same.. .

Mesenchymal stem cells with enhanced immunosuppressive capability

Compositions of hla-g+ msc and methods of using them, including methods of transplanting compositions of hla-g+ msc into human recipients, are provided. Also provided are methods of preparing compositions of hla-g+ msc, including by treatment with dna methylation inhibitors..
Escape Therapeutics, Inc.

Partially erodable systems for treatment of obstructive sleep apnea

The invention relates to devices and methods for reforming tissue surrounding the airway of a subject suffering from obstructive sleep apnea so as to open the airway and alleviate the occurrence of apneic events. Devices comprise a combination of resiliently deformable material and bioerodible material.

Methods, systems and instruments for creating partial model of a head for use in hair transplantation

The present disclosure provides for methods, systems and instruments for creating a partial model of a head for use in planning or tracking a procedure, such as hair transplantation. The methodology allows for an accurate 3d representation to be quickly and efficiently generated of an identified portion of the head, not the entire head, from two or more 2d images, such as still images.
Restoration Robotics, Inc.

Plant draw-in device and plant body transplantation system

To provide a plant draw-in device and a plant body transplantation system that can draw roots of plant bodies into holes reliably with a simple structure, so that there is no need of monitoring or manual operation for roots insertion and the production efficiency can be improved. The plant draw-in device 110 includes a draw-in tube 111 that can be disposed below a hole 121, a draw-in member 113 provided such as to be capable of protruding from the draw-in tube 111, and a drive unit 114 that reciprocally moves the draw-in member 113 such as to come out from, and retract into, the draw-in tube 111.
Tsubakimoto Chain Co.

Cross-species and intraspecies microsatellite markers for acropora corals

A method for identifying a subject of acropora genus to an acropora species comprises of detecting one or more microsatellite loci in the genome of the subject, wherein the microsatellite loci are selected from the group consisting of a microsatellite locus 8346m3 and others. A method for quantifying an index of level of chimerism of a coral colony restored by transplanting an acropora first coral colony of an acropora species into a second coral colony in need of restoration that belongs to the same species as the first coral colony comprises of identifying one or more microsatellite loci whose pcr fragment size, amplified with genomic dna derived from the first coral colony as template, is different from the pcr fragment size amplified with genomic dna derived from the second coral colony..
Okinawa Institute Of Science And Technology School Corporation

Megakaryocytic particles and microparticles for cell therapy & fate modification of stem and progenitor cells

Applications in transfusion medicine requiring platelets, and hematopoietic stem-cell transplantations require either platelets or enhancement of in vivo platelet biogenesis. Gene therapy applications of hematopoietic stem and progenitor cells (hspcs) require effective and specific modification of hspcs by dna, rna or other biological molecules.

Composition for organ, tissue, or cell transplantation, kit, and transplantation method

Disclosed are: a composition for organ, tissue or cell transplantation, containing, as an active ingredient, a peptide comprising the amino acid sequence of seq id no: 1, a peptide having at least 80% sequence homology with the amino acid sequence, or a peptide which is a fragment thereof; a kit comprising the composition; or a method using the composition. By using the composition, the kit, or the method, the viability and/or function of an organ, tissue, or cell after transplantation are strengthened and an organ, tissue or cell isolated from a living body is preserved temporarily without damage..
Gemvax & Kael Co., Ltd.

Substituted pyridazines as prostacyclin receptor modulators

Cyclohexane derivatives of formula ia and pharmaceutical compositions thereof that modulate the activity of the pgi2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (pah) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (sle); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (copd)..
Arena Pharmaceuticals, Inc.

Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders

Novel benzimidazoles according to formula i, able to inhibit jak are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic diseases, inflammatory diseases, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of il6 or hypersecretion of interferons.. .

Fgf-18 in graft transplantation and tissue engineering procedures

The present invention provides a new method related to regenerative medicine for the treatment of cartilage disorders, osteoarthritis and cartilage injury in particular. More particularly, it relates to an fgf-18 compound for use in tissue engineering and graft procedures, such as osteochondral or cartilage transplantation or autologous chondrocyte implantation (aci)..
Merck Patent Gmbh

Fusion protein for treating rejection reaction in transplantation

The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed..
Immunwork Inc.

Multi-arm linker for treating rejection reaction in transplantation

The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed..
Immunwork Inc.

Hyaluronic acid modified by sphingosine-1-phosphoric acid

Hyaluronic acid modified with sphingosine-1-phosphate, and a medicine comprising the hyaluronic acid as an active ingredient, wherein the medicine can alleviate hepatic disorder caused by hypoxia/reoxygenation by protecting the liver sinusoidal endothelial cells, and the medicine can prevent and/or treat liver failure due to liver transplantation, hepatectomy, or other surgeries associated with liver ischemia/reperfusion.. .
University Of Tsukuba

Autoimmune disorder treatment using rxr agonists

The present specification provides rxr agonist compounds, compositions comprising such rxr agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such rxr agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.. .
Dartmouth College

Automated harvesting or implanting follicular units

Automated systems and methods for creating a plan for performing a procedure (for example, hair transplantation) are provided. In some embodiments, the plan is generated automatically by a processor.
Restoration Robotics, Inc.



Transplant topics:
  • Transplant
  • Autoimmune
  • Immune Disease
  • Autoimmune Disease
  • Differentiation
  • Stem Cells
  • Antibodies
  • User Input
  • Quantitative
  • High Speed
  • Heterogeneous
  • Transplant Rejection
  • B Lymphocytes
  • Lymphocyte
  • Tissue Engineering


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    This listing is a sample listing of patent applications related to Transplant for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Transplant with additional patents listed. Browse our RSS directory or Search for other possible listings.


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