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 Memory system having a plurality of writing modes patent thumbnailnew patent Memory system having a plurality of writing modes
According to one embodiment, a memory system includes a non-volatile semiconductor memory, a block management unit, and a transcription unit. The semiconductor memory includes a plurality of blocks to which data can be written in both the first mode and the second mode.
Kabushiki Kaisha Toshiba


 Biologically active synthetic nanoparticle constructs and methods of use thereof patent thumbnailnew patent Biologically active synthetic nanoparticle constructs and methods of use thereof
This application discloses the compositions comprising biologically active synthetic nanoparticle constructs and methods of use thereof to modify gene expression including transcriptional activation and transcriptional repression.. .
Rutgers, The State University Of New Jersey


 Rna molecules and uses thereof patent thumbnailnew patent Rna molecules and uses thereof
The invention relates to a method of designing a short rna molecule to increase the expression of a target gene in a cell through the down-regulation of a non-coding rna transcript, said method comprising the steps of: a) obtaining the nucleotide sequence of the coding strand of the target gene, at least between 200 nucleotides upstream of the gene's transcription start site and 200 nucleotides downstream of the gene's transcription start site; b) determining the reverse complementary rna sequence to the nucleotide sequence determined in step a); and c) designing a short rna molecule which is the reverse complement or has at least 80% sequence identity with the reverse complement of a region of the sequence determined in step b); wherein said method does not include a step in which the existence of said non-coding rna transcript is determined; and to such short rna molecules and uses thereof.. .
Mina Therapeutics Limited


 Inhibitors of late sv40 factor (lsf) as cancer chemotherapeutics patent thumbnailnew patent Inhibitors of late sv40 factor (lsf) as cancer chemotherapeutics
The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. Heptacellular carcinoma.
Trustees Of Boston University


 Small molecule transcription modulators of bromodomains patent thumbnailnew patent Small molecule transcription modulators of bromodomains
This disclosure relates generally to compounds and compositions comprising one or more indole analogs. These compounds are useful for treating diseases associated with nf-kb and p53 activity, such as cancer and inflammatory diseases..
Icahn School Of Medicine At Mount Sinai


 Latency constraints for acoustic modeling patent thumbnailLatency constraints for acoustic modeling
Methods, systems, and apparatus, including computer programs encoded on computer storage media for acoustic modeling of audio data. One method includes receiving audio data representing a portion of an utterance, providing the audio data to a trained recurrent neural network that has been trained to indicate the occurrence of a phone at any of multiple time frames within a maximum delay of receiving audio data corresponding to the phone, receiving, within the predetermined maximum delay of providing the audio data to the trained recurrent neural network, output of the trained neural network indicating a phone corresponding to the provided audio data using output of the trained neural network to determine a transcription for the utterance, and providing the transcription for the utterance..
Google Inc.


 Polynucleotides and polypeptides in plants patent thumbnailPolynucleotides and polypeptides in plants
The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed..
Mendel Biotechnology, Inc.


 Novel fusion protein comprising transcription modulation domain of p65 and protein transduction domain, and uses thereof patent thumbnailNovel fusion protein comprising transcription modulation domain of p65 and protein transduction domain, and uses thereof
The present invention relates to a novel fusion protein comprising the transcription modulation domain of the transcription factor nf-κb subunit p65 and a protein transduction domain and to the use thereof. The fusion protein of the present invention has the effects of inhibiting the transcription of nf-κb and il-2 by competitive inhibition and inhibiting the lps-induced secretion of inflammatory cytokines and also inhibiting the production of il-2, ifn-γ, il-4, il-17a and il-10 in splenocytes, and thus is effectively used as a composition for the prevention or treatment of a disease related to nf-κb overactivity..

 Compositions and methods for targeting nuclear import shuttles and treating inflammatory disorders patent thumbnailCompositions and methods for targeting nuclear import shuttles and treating inflammatory disorders
The present invention relates to compositions and methods for treating autoimmune, microbial, metabolic, neoplastic, and posttraumatic diseases mediated by inflammation in a subject. Compositions and methods including at least one importin beta-selective nuclear transport modifier (ntm) and/or at least one importin alpha-selective ntm, and/or at least one importin alpha-specific ntm, and/or at least one inhibitor of importin alpha and importin beta complex formation may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease or abrogation of inflammation..
Vanderbilt University


 System and  automated language model adaptation patent thumbnailSystem and automated language model adaptation
Systems and methods of automated adaptation of a language model for transcription of audio data include obtaining audio data. The audio data is transcribed with a language model to produce a plurality of audio tile transcriptions.
Verint Systems Ltd.


Aav vectors for vascular gene therapy in coronary heart disease and peripheral ischaemia

The invention relates to the provision of a gene therapy for coronary heart disease and peripheral ischemia in mammals. One embodiment is an adeno-associated viral vector (aav vector) comprising a first gene encoding a myocardin-related transcription factor a (mrtf-a).

Method of therapy and diagnosis of endothelial dysfunction

The invention discloses a method of therapy of endothelial dysfunction, by administering microrna let-7g to a subject in need, wherein the microrna let-7g inhibits smad2 transcription factor from activation and translocation into nucleus, thereby decreasing monocyte cell adhesion, inflammation and thrombosis and increasing angiogenesis.. .
Kaohsiung Medical University

Method of treating ovarian, tubal and peritoneal cancer

A method of treating ovarian, tubal and peritoneal cancer is revealed. It comprises administering an effective amount of a pharmaceutical composition (including a copper chelator, a platinum-based chemotherapeutic agent and an anthracycline) to a subject in need thereof for reducing concentration of intracellular copper ions and promoting activation of transcription factor sp1 and human copper transporter 1 (hctr1)..
National Cheng Kung University Hospital

Bettering scores of spoken phrase spotting

Embodiments of the disclosed subject matter include a system and method for improving a phrase spotting score. The method may include providing a test speech and a transcription thereof, obtaining an input phrases in a textual form for spotting in the provided test speech, generating a phonetic transcription for the input phrase, and applying a classifying model to the phonetic transcription of the test speech according to a posterior probability feature and to a set of phrase spotting features related to the input phrase, the phrase spotting features selected from features extracted from a decoding process of the phrase, context-based features, and/or a combination thereof, thereby spotting the given phrase with a confidence score.
Nice-systems Ltd

Generation of induced pluripotent stem (ips) cells

The present invention relates to a method of generating an induced pluripotent stem (ips) cell comprising the step of introducing into a target cell one or two coding sequences each giving rise upon transcription to a factor that contributes to the reprogramming of said target cell into an induced pluripotent stem cell and selected from oct3/4 or a factor belonging to the myc, klf and sox families of factors, wherein the target cell endogenously expresses at least the factors that are not encoded by the coding sequences to be introduced and selected from oct3/4 or factors belonging to the myc, klf and sox families of factors, and wherein the cell resulting from the introduction of the one or two coding sequences expresses the combination of factor oct3/4 and at least one factor of each family of factors selected from the group of myc, klf and sox. Furthermore, the present invention relates to an induced pluripotent stem cell generated by the method of the invention and a method of identifying a compound that contributes to the reprogramming of a target cell into an induced pluripotent stem cell.
Max-planck-gesellschaft Zur Foerderung Der Wissenschaften E.v.

Compositions and methods for latent viral transcription regulation

The invention provides compositions and methods that can be used to regulate viral transcription. Using a catalytically inactive nuclease such as deactivated cas9, or dcas9, a guide rna can be designed that recognizes a regulatory element within a viral nucleic acid.
Agenovir Corporation

Transcription of spoken communications

A portion of speech is captured when spoken by a near-end user. A near-end user terminal conducts a communication session, over a network, between the near-end user and one or more far-end users, the session including a message sent to the one or more far-end users.
Microsoft Technology Licensing, Llc

System and analyzing and classifying calls without transcription via keyword spotting

A facility and method for analyzing and classifying calls without transcription via keyword spotting is disclosed. The facility uses a group of calls having known outcomes to generate one or more domain- or entity-specific grammars containing keywords and related information that are indicative of particular outcome.
Marchex, Inc.

Second harmonic imaging nanoprobes and techniques for use thereof

Second harmonic nanoprobes for imaging biological samples and a method of using such probes to monitor the dynamics of biological process using a field resonance enhanced second harmonic (fresh) technique are provided. The second harmonic generating (shg) nanoprobes are comprised of various kinds of nanocrystals that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy for in vivo imaging of biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, dna conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging..
California Institute Of Technology

Plant promoter and 3' utr for transgene expression

This disclosure concerns compositions and methods for promoting transcription and translation of a nucleotide sequence in a plant or plant cell, employing a 3′utr from arabidopsis thaliana ubiquitin-10 gene. Some embodiments relate to a 3′ utr from a arabidopsis thaliana ubiquitin-10 gene that functions in plants to terminate transcription of operably linked nucleotide sequences..
Dow Agrosciences Llc

Plant promoter and 3' utr for transgene expression

This disclosure concerns compositions and methods for promoting transcription and translation of a nucleotide sequence in a plant or plant cell, employing a 3′utr from arabidopsis thaliana ubiquitin c9 gene. Some embodiments relate to a 3′ utr from a arabidopsis thaliana ubiquitin c9 gene that functions in plants to terminate transcription of operably linked nucleotide sequences..
Dow Agrosciences Llc

Oligonucleic acid variant libraries and synthesis thereof

Disclosed herein are methods for the generation of highly accurate oligonucleic acid libraries encoding for predetermined variants of a nucleic acid sequence. The degree of variation may be complete, resulting in a saturated variant library, or less than complete, resulting in a selective library of variants.
Twist Bioscience Corporation

Rtef-1 variants and the use thereof for inhibition of angiogenesis

Dominant negative (dn) variants of transcriptional enhancer factor 1-related (rtef-1) are described. Dn rtef-1 polypeptides may be directly targeted to cells or delivered in nucleic acid expression vectors to alter cellular transcription.
Research Development Foundation

Compounds which inhibit rna polymerase, compositions including such compounds, and their use

Rna polymerase i (pol i) is a dedicated polymerase for the transcription of the 47s ribosomal rna precursor subsequently processed into the mature 5.8s, 18s and 28s ribosomal rnas and assembled into ribosomes in the nucleolus. Pol i activity is commonly deregulated in human cancers.
Lieber Institute For Brain Development

Automatic volume control of a voice signal provided to a captioning communication service

Apparatuses and methods are disclosed for automatic volume control of an audio stream reproduced by a captioning communication service for use by a call assistant in generating a text transcription of a communication session between a hearing-impaired user and a far-end user. The automatic volume control automatically adjusts a volume of the audio stream reproduced by the captioning communication service responsive to a volume control command identifying which of the far-end voice signal and the near-end voice signal is active at a given time.
Captioncall, Llc

Method for manufacturing light-emitting diode package

The present invention relates to a method for manufacturing a light-emitting diode package, and more specifically to a method for manufacturing a light-emitting diode package that does not need an additional colour conversion frit heat-treatment process and cutting process after bonding between the colour conversion frit and a light-emitting diode chip. To this end, the present invention provides a method for manufacturing a light-emitting diode package chatacterized in that the present invention comprises: a colour conversion frit formation step for forming a colour conversion frit in which phosphor is included on a substrate; a colour conversion frit transcription step for transcribing the colour conversion frit formed on the substrate from the substrate to a transcription film; and a colour conversion frit bonding step for bonding the colour conversion frit transcribed on the transcription film onto a light-emitting diode package..
Corning Precision Materials Co., Ltd.

Touchless compliance system

A touchless compliance method and system can include: a server beacon, the server beacon including a gesture sensor, a motion sensor, a microphone, a server beacon mass storage, and a server beacon power transceiver; detecting gesture data from the gesture sensor; recording audio data with the microphone; a power station including a power station power transceiver, a station control unit, upload coordinator, and a station storage unit; sending a packet from the server beacon to the power station; prioritizing the packet; uploading a message including the audio data to the power station; uploading the message to an audio database server; transcribing the audio data; and displaying the transcription along with an option to replay the audio data on an external computer.. .
Washsense Inc.

Virtual inference of protein activity by regulon enrichment analysis

Methods for determining regulon enrichment in gene expression signatures are disclosed herein. An example method can include obtaining a set of transcriptional targets of a regulon.
The Trustees Of Columbia University In The City Of New York

Method for differentiating between lung squamous cell carcinoma and lung adenocarcinoma

Provided is an approach for differentially determining the histological type of a lung cancer lesion objectively and rapidly with high accuracy. A method for differentially assessing a lesion in a lung cancer patient as squamous cell carcinoma or adenocarcinoma, comprising a step of measuring an expression level of an expression product of at least one dna comprising a transcription start site in a biological sample collected from the lesion, wherein the dna comprises a base at an arbitrary position in the transcription start site and at least one or more bases located immediately downstream thereof in any of nucleotide sequences represented by seq id nos: 1 to 213, and the transcription start site is a region wherein both ends thereof are defined by the first base and the 101st base counted from the 3′ end in any of the nucleotide sequences represented by seq id nos: 1 to 213..
Riken

Crispr-based genome modification and regulation

The present invention provides rna-guided endonucleases, which are engineered for expression in eukaryotic cells or embryos, and methods of using the rna-guided endonuclease for targeted genome modification in in eukaryotic cells or embryos. Also provided are fusion proteins, wherein each fusion protein comprises a crispr/cas-like protein or fragment thereof and an effector domain.
Sigma-aldrich Co. Llc

System and validating natural language content using crowdsourced validation jobs

Systems and methods of validating transcriptions of natural language content using crowdsourced validation jobs are provided herein. In various implementations, a transcription pair comprising natural language content and text corresponding to a transcription of the natural language content may be gathered.
Voicebox Technologies Corporation

System and providing words or phrases to be uttered by members of a crowd and processing the utterances in crowd-sourced campaigns to facilitate speech analysis

Systems and methods of providing text related to utterances, and gathering voice data in response to the text are provide herein. In various implementations, an identification token that identifies a first file for a voice data collection campaign, and a second file for a session script may be received from a natural language processing training device.
Voicebox Technologies Corporation

Word-level correction of speech input

The subject matter of this specification can be implemented in, among other things, a computer-implemented method for correcting words in transcribed text including receiving speech audio data from a microphone. The method further includes sending the speech audio data to a transcription system.
Google Inc.

Adapting a speech system to user pronunciation

A system and method of adapting a speech system includes the steps of: receiving confirmation of a phonetic transcription of one or more names, receiving confirmation of a selected stored text result, and storing the phonetic transcription with the selected stored text result using an automatic speech recognition (asr) system, a text-to-speech (tts) system, or both.. .
Gm Global Technology Operations Llc

Systems and methods for efficient neural network deployments

Disclosed are systems and methods that implement efficient engines for computation-intensive tasks such as neural network deployment. Various embodiments of the invention provide for high-throughput batching that increases throughput of streaming data in high-traffic applications, such as real-time speech transcription.
Baidu Usa Llc

Method for production of polypeptides

The current invention reports a promoter that has the nucleic acid sequence of seq id no: 02 or seq id no: 03 which is a human cmv major immediate-early (hcmv-mie) promoter/enhancer with c to g point mutation at position −41 and/or −179 relative to the transcription start site. This new promoter is especially useful for the production of polypeptides at large scale as it shows reduced promoter silencing and improved polypeptide production..
Hoffmann-la Roche Inc.

Methods and compositions relating to restricted expression lentiviral vectors and their applications

The present invention provides hiv-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic progenitor cells as well as in all other blood cell derivatives. The lentiviral vectors comprise promoters active to promote expression specific to cell types or tissues.
Research Development Foundation

Transcription factor sequences for conferring advantageous properties to plants

The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference or control plant, including increased plant size, seed size, increased leaf size, lignification, water deprivation tolerance, cold tolerance, or altered flowering time. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed..
Mendel Biotechnology, Inc.

Plants having one or more enhanced yield-related traits and a making the same

Provided is a method for enhancing one or more yield-related traits in a plant by modulating expression in the plant of a nucleic acid encoding an anac055 (arabidopsis no apical meristem, arabidopsis transcription factor, cup-shaped cotyledon) polypeptide. Also provided are plants having modulated expression of a nucleic acid encoding an anac055 polypeptide, which plants have one or more enhanced yield-related traits compared with control plants.
Basf Plant Science Company Gmbh

Method for in situ inhibition of regulatory t cells

The present invention pertains to engineered t-cells, method for their preparation and their use as medicament, particularly for immunotherapy. The engineered t-cells of the invention are designed to express both a chimeric antigen receptor (car) directed against at least one antigen expressed at the surface of a malignant or infected cell, and a secreted inhibitor of regulatory t-cells (treg).
Cellectis

Monoclonal antibody against human prpc and use thereof

A monoclonal antibody against human prpc protein capable of reducing the expression level of transcription factor twist1 in a targeting mode and inducing macrophage and nk cells to target to rectal cancer tumor cells. The combined drug therapy with the antibody and cetuximab also exhibits inhibitory effect on tumor better than administration of the antibody or cetuximab alone..
Institute Of Zoology, Chinese Academy Of Sciences

Indolinone compounds and uses thereof

Indolinone derivative compounds that act as ews-fli1 transcription factor inhibitors are provided. Also provided are pharmaceutical compositions of the indolinone derivatives, methods of synthesizing the same, methods of treating using same, and assays for identifying the inhibitors of ews-fli1 oncoprotein..
Oncternal Therapeutics, Inc.



Transcription topics:
  • Transcription
  • Nucleic Acid
  • Gene Expression
  • Nucleotide
  • Speech Recognition
  • Nucleic Acids
  • Transactions
  • Client Side
  • Advertisement
  • Fulvestrant
  • Amplification
  • Polymerase Chain Reaction
  • Differentiation
  • Polymerase
  • Quantitative


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