|| List of recent Topical-related patents
| Compositions and methods for controlling drug loss and delivery in transdermal drug delivery systems|
A transdermal delivery system is provided for the topical application of one or more active agents contained in one or more polymeric and/or adhesive carrier layers, proximate to a non-drug containing polymeric and/or adhesive coating that is applied to either the transdermal system's backing or release liner. The transdermal delivery device is manufactured to optimize drug loading while providing desirable adhesion to skin or mucosa as well as providing modulation of the drug delivery and profile..
| Stable, non-irritating topical formulations of hydroquinone|
Described herein are methods and compositions for increasing the efficacy and decreasing the irritancy of topical formulations of hydroquinone.. .
| Topical antiandrogen therapy for the treatment of becker's nevus|
This invention relates to the treatment of beckers nevus with antiandrogenic topical agents, including 5-alpha reductase inhibitors, non-steroidal antiandrongens and steroidal antiandrogens.. .
| Topical dtpa prodrug formulations and methods of using the same|
The present invention relates to topical trisodium diethylenetriamine pentaacetic acid (dtpa) prodrug formulations and methods of using the same.. .
| Combinations of indigo naturalis and berberine and uses thereof|
Methods and composition for treating or preventing an inflammatory dermatological disease or condition, such as psoriasis, in a subject are described. The methods involve topical applications to the subject a therapeutically effective amount of a composition comprising at least one indigo naturalis composition, beberine and a pharmaceutically acceptable carrier..
| Controlling the bioavailability of active ingredients in topical formulations|
Described are methods and compositions for tuning the bioavailability of an active agent, such as a corticosteroid, in a topical formulation.. .
| Topical formulations of corticosteroids with enhanced bioavailability|
Described herein are methods and compositions for increasing the bioavailability of a corticosteroid, such as hydrocortisone 17-butyrate, in a topical formulation.. .
| Petroleum jelly-free unguent compositions comprising vitamin d compounds and optionally steroidal anti-inflammatory agents|
Novel compositions in petroleum jelly-free unguent form, in particular for topical application, contain a vitamin d compound and optionally an active agent of the family of steroidal anti-inflammatory agents.. .
| Method of enhancing health of a person|
A method of enhancing health of a person includes administering stable water clusters to persons having an autoimmune disease, pain, a chronic disease, a mental disease, a genetic disease from malfunction of a normal dna, being an athlete for improving his performance and alleviating soreness, suffering from overworking, stress and toxins etc., by drinking a solution containing stable water clusters, swallowing small objects which contain the stable water clusters, putting a topical cream which contains the stable water clusters on skin, breathing the stable water clusters through mouth, putting drops which contain the stable water clusters into eyes, ears or nose, cleaning colon with solution that contains the stable water clusters, eating food that contains the stable water clusters, injecting solution that contain the stable water clusters into blood vessel etc.. .
| Compositions with thermally-regulating material|
Cosmetic compositions for topical application to the skin comprising at least one phase change material (pcm) in combination with a cosmetically compatible carrier, and methods for maintaining the skin of a wearer of a cosmetic product at a comfortable temperature, are provided.. .
| Topical compositions and methods of using the same|
The present invention relates generally to topical compositions and methods of using the same.. .
| Methods for treating uv-damaged skin and scc tumors and for removing tattoos with topical ingenol mebutate|
The present invention is further directed to a topical field-directed treatment for the removal of tattoos from skin with ingenol mebutate. By way of example, the present invention is directed to removing tattoos with topical ingenol mebutate at concentrations of up to about 0.25%..
| Bioactive compositions from theacea plants and processes for their production and use|
The present invention relates to isolated bioactive compositions containing bioactive fractions derived from theacea plants. The present invention also relates to bioactive topical formulations containing the bioactive compositions.
| Topical sunscreen compositions|
Substantially anhydrous compositions including at least 10% by weight of a c2 or c3 mono-alcohol, a solid, organic uv-filter dissolved therein; and an oil portion including one or more oils, the oil portion having an interfacial tension with water of greater than 9 and less than 45, where the composition has a volume fraction of oil relative to oil plus c2 or c3 mono-alcohol that is about 0.47 or greater, and is substantially free of a mixture of a low-volatility, c2-c8 liquid silicone and a branched fatty acid ester of a polyprotic carboxylic acid in a ratio of from about 3:1 to 4.25:1.. .
| Topical preparation containing ngf for inducing skin pigmentation and for the treatment of cutaneous dyschromias and vitiligo|
The preparation of ngf and the connected method can also be used in combination with other therapies known for the treatment of skin discoloration, such as the application of topical corticosteroids, activated vitamin d and/or activated vitamin d3, or phototherapy alone or in combination with photosensitizing agents, in particular psoralens.. .
| Topical sunscreen compositions|
Substantially anhydrous compositions including at least 10% by weight of a c2 or c3 mono-alcohol, a solid, organic uv-filter dissolved therein; and an oil portion including one or more oils, the oil portion having an interfacial tension with water of greater than 9 and less than 13.9. The composition has a volume fraction of oil portion relative to the sum of the oil portion plus c2 or c3 mono alcohol that is greater than 0.091..
| Thermoformed load bearing pallet|
The loadable and readily moveable thermo-plastically constructed pallets of the present invention utilize three directionally longitudinally extending beams extending integrally downwardly from a horizontal and topically loadable panel. Respective beams at the lower-side are provided with a plurality of transversely alignable cutaways, including two medial-cutaways and two flanking-cutaways, the latter being adapted to rest rack wise upon a range of spaced apart rails.
|Methods using social topical adaptive networking system|
A machine-implemented social networking system builds up and repeatedly refreshes a hierarchy tree containing topic nodes. New nodes are added as new topics emerge in online public forums.
|Systems and methods for topical grouping of search results and organizing of search results|
Embodiments include a method for providing two or more search results. The method can include receiving at least one search parameter from a search query of a first user.
|Compositions, methods, devices, and systems for skin care|
Accordingly, a need has arisen for improved compositions, methods, devices, and systems for skin care including, without limitation, topical compositions and phototherapy devices and methods. A skin care method may comprise, in some embodiments, contacting at least a portion of the skin of a subject with a homogeneous, stable, self-foaming composition, illuminating the at least a portion of the skin exclusively with light of a desired wavelength (e.g., from about 390 nm to about 430 nm, and contacting the at least a portion of the skin with an anti-oxidant serum composition..
|Vacuum assisted wound dressing|
Apparatus for the application of topical negative pressure therapy to a wound site is described, the apparatus comprising: a wound contacting element for retaining wound exudate fluid therein; a wound covering element that provides a substantially airtight seal over the wound contacting element and wound site; a vacuum connection tube connecting a wound cavity to a vacuum source; and a vacuum source connected to a distal end of the vacuum connection tube.. .
|Topical ophthalmological pharmaceutical composition containing sorafenib|
The present invention relates to topical ophthalmological pharmaceutical compositions containing sorafenib or a pharmaceutically acceptable salt thereof or a polymorph, hydrate or solvate thereof and its process of preparation and its use for treating ophthalmological disorders.. .
|Methods for treatment of atopic dermatitis and inflammatory skin disorders|
The present invention provides methods for the treatment of atopic dermatitis and other inflammatory skin disorders. It has been found that topical application of alcaftadine compositions is useful for prophylaxis and symptomatic management of atopic dermatitis and associated symptoms..
|Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent|
An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne.
|Ophthalmic formulation derived from silk protein|
An ophthalmic composition is described for the treatment of dry eye syndrome in a human or mammal. The composition comprises an aqueous solution including an effective amount of silk protein.
|Moist heat drug delivery apparatus and method|
A novel moist steam heating cabinet unit is used as a medical device for humidification, hydration, and dispensing of medicinal hot packs. The technology provides multifunctional options from both medicine and non-medicinal hot pack treatment, as well as for other applications and uses, for example—including creation, manufacturing, and curing of pharmaceutical compounds that require a controlled steam process and method.
|Topical composition for stimulating epidermis and dermis layers of the skin|
The invention provides topical compositions including vitamin a, colostrum (or extracts of colostrum with a high igf content) with or without avian eggshell membrane, that stimulate the epidermis and dermis layers of the skin to treat skin aging.. .
|Pharmaceutical methods and topical compositions containing acitretin|
The present invention is directed to methods and compositions for topical administration of acitretin. More specifically, the present invention is related to methods and compositions for the treatment or prevention or reduction of symptoms or signs of dermatological conditions using acitretin in a topical administration.
|Topical dermal delivery compositions using self assembling nanoparticles with cetylated components|
The invention, a transdermal delivery method, relates to penetration-enhancing pharmaceutical compositions comprising a novel, stable mixture of cetylated esters, cetyl or stearyl alcohols, polar solvents and surfactants, which, under appropriate conditions, combine into amphiphilic nanoparticles within a stabilized liquid dispersion for use in delivery of medicinal agents through the skin. The term cetosomes is used to describe these particles in order to differentiate them from other nanoparticles, such as niosomes, cerasomes, polymeric micelles, dendrimers, liposomes, lipoids, solid lipid nanoparticles and other particles.
|Dental anesthetic comprising tetracaine and a vasoconstrictor for intranasal administration|
The present invention relates to tetracaine based anesthetic formulations and methods of use thereof. The invention further relates to topical formulations of tetracaine and methods of topically anesthetizing body tissues.
|Method of treating skin disorders using nanoscale delivery devices and transdermal enhancing compositions|
The present invention describes methods and compositions for treating diverse dermatological conditions, including acne and psoriasis, using zein containing nanocarrier devices for topical delivery of methotrexate, retinoic acid and benzoyl peroxide to select targets in the skin.. .
|Plaster having adjustable occlusion|
Transdermal or topical plasters containing active ingredient are provided that include a non-occlusive back layer, a matrix formed from of one or more polymer layers having at least one pharmaceutical active ingredient in one or more of the layers, in which the structure-forming base polymers of the layer(s) are non-occlusive or only slightly occlusive and a second polymer that has a low water-vapor permeability and that is immiscible or only very slightly miscible with the base polymer is dispersed in at least one of the polymer layers.. .
|Lobster hemolymph as a utility for treatment of mammalian tissue lesions|
The invention is crustacean hemolymph as a utility for the pharmaceutical and/or cosmetic treatment of viral and other neoplastic or pre-neoplastic mammalian tissue lesions. The method comprises topically administering to mammalian tissue a formula that is made from lobster hemolymph—neat; or lobster hemolymph extracts; or lobster hemolyph in combination with certain carriers, binders; or as an adjuvant.
Disclosed is a topical skin composition, and methods for its use, that includes arctium lappa root extract, epilobium angustifolium extract, and cystoseira amentacea/caespitosa brachycarpa extract.. .
|Skin care formulations|
Disclosed is a method of firming skin or reducing the appearance of fine lines or wrinkles comprising topically applying, to skin in need thereof, a composition comprising palmitoyl tetrapeptide 7 and a dermatologically acceptable vehicle comprising water, glycerin, butylene glycol, propylene glycol, and a chelating agent, wherein topical application of the composition to the skin firms the skin or reduces the appearance of fine lines or wrinkles, and wherein the composition is not a sunless tanning composition.. .
|System and method of complimentary day/night children's skin cream compositions|
A new skin care system includes day and night skin cream compositions comprising nutrients and antioxidants for use by children between six months and eighteen years of age. The day skin cream composition provides protection from uv radiation and the night skin cream composition contains no sun protection ingredients and elevated levels of nutrients and antioxidants.
|Targeted buccal delivery of agents|
A delivery device for topical and systemic delivery of agents to targeted oral locations, such as mouth cancer cells, has been developed. The formulation includes a mucoadhesive polymeric matrix such as chitosan, which contains one or more therapeutic and/or diagnostic agents, taste masking agents, permeation enhancers, the therapeutic or diagnostic agent to be delivered, and a hydrophilic polymeric coating such as polyethyleneglycol (“peg”).
|Method of accelerating corneal wound healing|
The topical ophthalmic use of 5,6,7-trihydroxyheptanoic acid and analogs for the acceleration of corneal wound healing in humans, is disclosed.. .
|Topical ocular analgesic agents|
The topical ophthalmic use of certain 2,4-diamino-substituted 1,3-triazines for preventing or alleviating ocular pain in patients is disclosed. Topcial ocular pharmaceutical composition are also disclosed..
|Methods and compositions for enhancing hair quality using blackberry extract|
Compositions and methods for inducing hair growth and improving hair quality utilizing extracts of blackberry in an amount effective to induce hair growth when applied topically to an area of the skin on which hair growth is desired.. .
|Multifunctional topical formulation for the treatment of acne vulgaris and other skin conditions|
A two-part aqueous composition for treating skin ailments, such as acne vulgaris, includes an acidic part having salicylic acid and an α-hydroxy acid, and an alkaline part having an alkaline nitrite salt. The α-hydroxy acid is preferably glycolic acid, lactic acid, malic acid, mandelic acid or a combination thereof.
|Silver oxide formulations|
Topical formulations for application to exposed body tissue.. .
|Composition for coloring skin and method for coloring skin|
Compositions for coloring skin are described. The compositions comprise beads that comprise petrolatum and optionally a colorant and the beads have a diameter from about 90 to about 625 microns.
|Capsule whose envelope is separately imperceptible during the topical use thereof|
A capsule for cosmetic and/or dermatological ingredients and processes for the production thereof. The capsule comprises an envelope which is solid, semisolid and/or dimensionally stable and comprises one or more substances which are selected from waxes, emulsifiers, and natural and synthetic polymers.
|Protection against sunburn and skin problems with topical and orally-ingested dosages of zeaxanthin|
A carotenoid substance called zeaxanthin, when ingested orally at suitable dosages such as 30 to 100 mg/day for a span of 1 to 2 weeks, can provide effective protection against sunburns, and can give skin a darker tint that emulates a healthy suntan. In tests involving adults, it was found that zeaxanthin dosages of 30 to about 80 mg per day were sufficient to induce: (i) a mild but noticeable tinting, shading, or darkening of skin color, comparable to a mild suntan; (ii) a substantial increase in the person's ability to withstand elevated levels of sun or uv exposure without any subsequent pain or discomfort, and without the subsequent peeling and flaking that characterizes sunburns; and, (iii) an increased ability of reddened and sunburned skin to convert into intact skin that looks browned and healthily tanned.
The present invention relates to topical compositions comprising at least one benzotriazol derivative and at least one uv filter substance selected from the group consisting of a triazine derivative and an amino substituted hydroxybenzophenone as well as mixtures thereof.. .
|Multi-dose dispenser and applicator for topical medications|
A multi-dose, metered dispenser and applicator for topical medications includes inner and outer cylinders and a plurality of expanding bases. These bases form part of a telescopic piston drive system that advances the main piston through the inner cylinder, in accordance with a selected dosage, to dispense a metered amount of the topical medication.
|Combination of an oxidant and a photoactivator for the healing of wounds|
There is provided a wound healing composition which comprises at least one oxidant, at least one photoactivator capable of activating the oxidant and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin in association with a pharmaceutically acceptable carrier. In addition, a method of topically treating wounds using at least one oxidant and at least one photoactivator capable of activating the oxidant followed by illumination of said photosensitizer is disclosed..
|Boron-containing small molecules|
This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus.
|Highly concentrated astaxanthin for topical application|
A method for obtaining and topically applying a customized resulting mixture, wherein the customized resulting mixture contains astaxanthin at an individualized concentration, the method comprising: placing in a mixing place a desired amount of a highly concentrated astaxanthin composition of known astaxanthin concentration, the astaxanthin concentration being between about 0.01% to about 5% by weight; placing a proportional amount of a substance near the highly concentrated astaxanthin composition; mixing the substance with the highly concentrated astaxanthin composition to obtain the customized resulting mixture; and, topically applying the customized resulting mixture.. .
|Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide f2 alpha agonists|
The present invention is directed to compositions and methods for the treatment of post-chemotherapeutic hypotrichosis. More specifically, the present invention is directed to the use of compositions comprising bimatoprost for the treatment of post-chemotherapeutic hypotrichosis which may be applied before, during and after receiving chemotherapeutic treatment..
|Topical minocycline ointment for suppression of allergic skin responses|
The method of the present application is directed towards a method for suppressing an allergic response in response to an allergic trigger. This method comprises the following steps; applying, topically, to an affected area an effective amount of a minocycline composition so that the minocycline composition contacts the affected area for an effective amount of time and removing the minocycline composition from the affected area..
|Topical antiviral formulations|
The disclosure provides antiviral pharmaceutical compositions comprising one or more antiviral compounds and 2-deoxy-d-glucose in the form of lip-balms, creams and ointments. A specific embodiment discloses a lip-balm composition comprising acyclovir and 2-deoxy-d-glucose..
|Capillary absorption spectrometer and process for isotopic analysis of small samples|
A capillary absorption spectrometer and process are described that provide highly sensitive and accurate stable absorption measurements of analytes in a sample gas that may include isotopologues of carbon and oxygen obtained from gas and biological samples. It further provides isotopic images of microbial communities that allow tracking of nutrients at the single cell level.
|Compositions for the treatment of peripheral ulcers of various origins|
The present invention relates to combinations of an agent that stimulates cell proliferation and an anti-inflammatory/analgesic, which are useful in the treatment of peripheral ulcers of various origins, such as radiation dermatitis, diabetic ulcers, ulcers caused by venous stasis of the limbs, bedsores, and the associated skin infections, proctitis, vulvovaginitis and haemorrhoids with vascular lesions. These combinations can be presented as formulations for topical use..
|Skin rejuvenation cream|
This invention is based upon the discovery that a mixture of ethyl lactate and isoamyl lactate can be used to improve the penetration of active ingredients in skin care formulations through the outer layers of the stratum corneum and viable epidermis and into the dermis layer of the skin structure. The present invention more specifically discloses a method of rejuvenating skin affected by intrinsic aging and/or photo-induced aging comprising topically applying a topical formulation to the skin, wherein said topical formulation is comprised of ascorbic acid, an amino acid selected from the group consisting of phenylalanine and tyrosine, a non-toxic zinc salt, carnosic acid, α-tocopherol, 0.01 weight percent to 20 weight percent of a mixture of ethyl lactate and isoamyl lactate, wherein the weight ratio of the ethyl lactate to the isoamyl lactate is within the range of 1:10 to 20:1, and a pharmaceutically acceptable carrier..
|Substantially dry nicotinamide pads for treatment of skin inflammation|
A substantially dry nonwoven pad is provided containing a formulation comprising nicotinamide in an amount between about 1% to about 10% w/w based on the total weight of the formulation and at least one water-soluble gritty polymer in an amount between about 10% to about 75% w/w based on the total weight of the formulation. The nicotinamide-containing pad is used topically for treatment of skin inflammation, in one easy step.
|Treatment and composition for wound healing|
Delivery systems including gels, sponges, gauzes and meshes incorporating the agent for topical administration are also described.. .
The present invention relates to a composition for topical application comprising at least a benzotriazol derivative and a cosmetic solvent selected from the group consisting of benzoate solvents such as phenethyl benzoate, dimethyl capramide and diethylhexyl 2,6-naphthalate. Furthermore, the invention relates to the use of specific benzotriazol derivatives to mask the off-odor of cosmetic solvents such as particularly phenethyl benzoate, dimethyl capramide and diethylhexyl 2,6-naphthalate..
The present invention relates to a composition for topical application in the form of an oil-in-water (o/w) emulsion comprising in a physiologically acceptable medium at least a dibenzoylmethane derivative, an amino substituted hydroxybenzophenone derivative and a benzotriazol derivative.. .
|Topical sunscreen compositions|
Substantially anhydrous compositions including at least 10% by weight of a c2 or c3 mono-alcohol, a solid, organic uv-filter dissolved therein; and an oil portion including one or more oils, the oil portion having an interfacial tension with water of greater than 9 and less than 32.5, where the composition has a volume fraction of oil relative to oil plus c2 or c3 mono-alcohol that is about 0.44 or greater, and is substantially free of a mixture of a low-volatility, c2-c8 liquid silicone and a branched fatty acid ester of a polyprotic carboxylic acid in a ratio of from about 3:1 to 4.25:1. .
|Topical bioadhesive formulations|
The present invention relates to topical bioadhesive formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament..
|Topical oily foam compositions|
Topical alcohol-free thermo labile oily foam composition comprising (i) at least one active pharmaceutical ingredient or ectoparasitic active ingredient; (ii) at least about 20% w/w of at least one lipophilic component; (iii) at least about 10% w/w of at least one non-ionic surfactant; (iv) at least about 0.5% w/w of at least one fatty alcohol or fatty acid or ester thereof with melting point above 30° c., and; (v) at least about 7% w/w of propellant selected from propane, butane, isobutene and combinations thereof; said composition optionally comprising at least about 5% to about 70% w/w of a hydrophilic component, optionally comprising up to about 5% w/w hydrogenated oil and optionally comprising a penetration enhancer. .
|Medical tissue-marker and manufacturing method for the same|
The present invention is to provide a medical tissue-marker which enables the identification of a location even from the outside of an organ, can remain topical over a long period, and enables the easy identification of a marked location within the whole organ; also to provide a manufacturing method for the medical tissue-marker. The medical tissue-marker as in the present invention includes a vesicle formed by the synthesis of a phospholipid and a near infrared fluorescent dye, and an emulsion formed by the synthesis of the phospholipid and an x-ray contrast medium, and has agglomerated clusters wherein the vesicle and the emulsion are contained in a hydrophilic solvent and a plurality of capsules are formed by means of an emulsifier..
|Medication delivery, dosing and safety devices, systems and kits|
Embodiments described herein generally relate to improved devices, systems, kits, products and methods related to topical medicament application of measured dosages. The kits and devices can single use and/or disposable for example..
An applicator having a concave surface comprising a non-absorbing elastomeric material is effective in topically compositions to minimize the appearance of fine facial hair on women.. .
|Compositions and methods for treating surface wounds|
The invention provides synergistic compositions and methods to prevent and treat dermal wounds and topical ulcers rapidly, efficaciously and economically. It comprises a synergistic combination of natural products, specifically the combination of an extract of hydrastis canadensis, an extract of a species of the genus panax and an extract of a aloe barabadensis l.
|Topical compositions and methods for making and using same|
The present invention relates to improved topical gel compositions comprising an active agent, and uses thereof.. .
|Methods of skin whitenening by use of canola extracts|
Compositions and methods for lightening skin are provided. A method for lightening skin may include the step of identifying skin where lightening or whitening is desired and topically applying to the skin a composition including (a) a skin lightening agent comprising a canola extract and (b) a cosmetically acceptable carrier.
|Methods and compositions for treating foot or hand pain|
The present disclosure provides novel formulations for treating foot or hand pain by topically administering a sympathomimetic drug, particularly oxymetazoline, to the skin of the foot or hand.. .
|Methods for treating eye disorders using opioid receptor antagonists|
The present invention discloses methods for treating eye disorders using opioid receptor antagonists. The methods include the step of administering an effective amount of a topically-administered opioid receptor antagonist in the absence of moxifloxacin.
|Topical compositions and methods for making and using same|
The present invention relates to improved topical gel compositions comprising an active agent, and uses thereof.. .
|Ophthalmic suspension for ocular use|
A gatifloxacin and prednisolone topical ophthalmic pharmaceutical compositions for prevention and treatment of ophthalmic bacterial infections and inflammatory conditions associated with pre-surgical and/or post surgical ocular surgeries.. .
|Macrocyclic insulin-degrading enzyme (ide) inhibitors and uses thereof|
Macrocyclic compounds that specifically inhibit insulin degrading enzyme (ide) are provided. Pharmaceutically acceptable salts, solvates, hydrates, stereoisomers, polymorphs, tautomers, isotopically enriched forms, and prodrugs of the macrocyclic ide inhibitors are also described.
|Novel method for improving the foaming properties of cleaning compositions for topical use|
Method for improving foaming properties of cleaning compositions for topical use, having a 4.0≦ph≦6.5, and including at least one foaming surfactant, includes incorporating an effective quantity of a cross-linked anionic polyelectrolyte into the cleaning composition, the cross-linked anionic polyelectrolyte being obtained through polymerization, in the presence of at least one cross-linking agent, of at least one monomer having a strong acid function, the monomer being 2-methyl 2-[(1-oxo 2-propenyl)amino]1-propanesulfonic acid, which is partially or completely salified, with at least one neutral monomer selected from the n,n-dialkyl acrylamides, wherein each of the alkyl groups includes between one and four carbon atoms and at least one monomer of formula (i), in which r is a linear or branched alkyl radical including eight to twenty carbon atoms, and n is a number greater than or equal to one and less than or equal to twenty.. .