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Topical

Topical-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Analyzing a complex sample by ms/ms using isotopically-labeled standards
Thermo Finnigan Llc
November 30, 2017 - N°20170345632

A method and corresponding apparatus are disclosed for analysis of a peptide-containing sample. The sample is prepared by adding isotopically-labeled peptides corresponding to endogenous peptides of interest, and the prepared sample is analyzed by liquid chromatography-mass spectrometry (lcms). Detection in a high-resolution, accurate mass (hram) ms1 spectrum of a precursor ion matching an isotopically-labeled peptide triggers acquisition of an ms/...
Indazole sulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (ror gamma (t))
Thermo Finnigan Llc
November 30, 2017 - N°20170342062

Pharmaceutical compositions including such compounds, as well as the use thereof for the topical and/or oral treatment of rorγt receptor-mediated inflammatory diseases, in particular acne, psoriasis and/or atopic dermatitis are also described.
Method and catalyst for synthesising aziridine
University Of East Anglia
November 30, 2017 - N°20170342030

The present invention relates to methods of synthesizing aziridines including isotopically labelled aziridines, said methods comprising contacting an imine or one or more precursors thereof with a diazo compound in the presence of a phosphoramide or a phosphoramide-derived catalyst. The present invention also relates to aziridines, modified aziridines and aziridine-derived compounds preparable by the aforementioned methods, and to phosphoramide or ...
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Compositions and methods for topical treatment of tar responsive dermatological disorders
Neostrata Company, Inc.
November 30, 2017 - N°20170340667

Compositions and methods for treating tar-responsive dermatological disorders are described. In particular, an anhydrous tar composition including a liquid wax and a therapeutically effective amount of tar in an anhydrous solvent, the composition being in liquid form at room temperature is described. The anhydrous tar composition can be topically applied to skin of a subject for treatment of tar-responsive dermatological ...
Topical aqueous spray compositions of halobetasol
Sun Pharmaceutical Industries Limited
November 30, 2017 - N°20170340649

The present invention relates to topical aqueous spray compositions of halobetasol. The topical aqueous spray compositions may be in the form of solutions or emulsions. It also relates to processes for the preparation of the topical aqueous spray compositions. It further relates to a method of treating topical skin conditions by administering said topical aqueous spray compositions.
Compositions and methods for skin care
Antipodean Pharmaceuticals, Inc.
November 30, 2017 - N°20170340603

Compositions and methods are for disclosed for treating a skin condition that results from reactive oxygen species production in skin of a subject, including applying a topical formulation that contains a lipophilic cation-mitochondrially targeted antioxidant compound and that delivers a therapeutically effective amount of the antioxidant compound to skin fibroblasts and keratinocytes.
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Topical Patent Applications
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Digital alloy vertical lamellae finfet with current flow in alloy layer direction
International Business Machines Corporation
November 23, 2017 - N°20170338308

After forming semiconductor fins including vertically oriented alternating first digital alloy sublayer portions comprised of sige and second digital alloy sublayer portions comprised of si on sidewalls of a sacrificial fin located on a substrate, the sacrificial fin is removed, leaving the semiconductor fins protruding from a top surface of the substrate. The sige and si digital alloy sublayer portions ...
Dispesning devices for topical pharmaceuctal compositions
International Business Machines Corporation
November 23, 2017 - N°20170333688

The present invention provides devices for dispensing topical pharmaceutical compositions. In some embodiments, the dispensing device possesses a reservoir for storing the composition and means for metering the composition. In some embodiments, such reservoirs are: i. Made from, or substantially lined with, a material that opaque and/or substantially nondepleting of at least one component of the composition; ii. Optionally, ...
Negative-pressure therapy with pneumatically-actuated instillation
Kci Licensing, Inc.
November 23, 2017 - N°20170333605

New and useful systems, apparatuses, and methods for providing negative-pressure therapy with instillation of topical treatment solutions are described. An apparatus may comprise an exudate container, a solution source, and a pneumatically-actuated instillation regulator. The instillation regulator may be coupled to the exudate container and to the solution source, and negative pressure from a negative-pressure source can actuate the instillation ...
Products and devices for controlling and stopping bleeding and methods of using
Cellphire, Inc.
November 23, 2017 - N°20170333593

Systems, devices, compositions, and methods for treating bleeding, for containing blood that has been lost by a subject due to bleeding, and for treating surfaces contaminated with blood or expected to be contaminated with blood are disclosed. The systems, devices, compositions, and methods utilize platelets, platelet-derived materials, or both. The invention includes sprayers, nebulizers, and equivalents, to deliver platelets and/...
Topical medicament for skin and mucosal injuries associated with epidermolisis bullosa
Rev Pharma Corp
November 23, 2017 - N°20170333489

A composition and method for treating epidermolisis bullosa (eb), comprising: applying to skin or mucosal surfaces of a patient in need of treatment for eb a dressing gauze or bandage without prior cleaning of said skin or mucosal surfaces, wherein distributed on said dressing is an effective amount of a composition containing beeswax; an oleaginous base, vitamins and a pharmaceutically ...
Compositions and methods for treating an infection
Cmpd Licensing, Llc
November 23, 2017 - N°20170333467

A method of treating or preventing one or both of a bacterial infection or fungal infection of a foot of a subject includes combining a diluent and at least one of a clindamycin solution or an erythromycin solution to form a footbath solution. The method may further include topically administering the footbath solution to the subject. Administering may include contacting ...
Compositions and formulations of glucosamine for transdermal and transmucosal administration
Cmpd Licensing, Llc
November 23, 2017 - N°20170333463

Disclosed are compositions and formulations comprising glucosamine or a pharmaceutically acceptable salt thereof for use in the treatment of joint conditions and adapted for use in a bath or soak or bath beads, powders, salts, and oils, kits, and methods of treatment using the same. Also disclosed are lozenges, suppositories, patches, and topical creams comprising glucosamine or a pharmaceutically acceptable ...
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Topical Patent Applications
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Compounded formula for menopause relief
Soligenix, Inc.
November 23, 2017 - N°20170333446

A sub-prescription strength composition of progesterone, estriol, and dehydroepiandrosterone to treat menopause symptoms administered by a topical cream.
Ite for cancer intervention and eradication
Ariagen, Inc.
November 23, 2017 - N°20170333401

A method of cancer intervention or eradication by administering an effective amount of an endogenous ligand for the aryl hydrocarbon (ah) receptor (ahr) named ite or one of its analogs (the active ingredient) to a subject with cancer is disclosed. An effective dose and dosing frequency of the active ingredient are determined by measuring its blood levels of the subject ...
Topical formulations of biaryl heterocyclic compounds and methods of use thereof
Melinta Therapeutics, Inc.
November 23, 2017 - N°20170333400

The present invention relates to topical formulations of biaryl heterocyclic compounds and methods of use thereof for treating acne and other skin infections caused or mediated by streptococcus pyogenes, streptococcus agalactiae, haemophilus influenza, trichomonas vaginalis, klebsiella sp., enterobacter sp., proteus sp., propionibacterium acnes, gardnerella vaginalis, or staphylococcus aureus (including methicillin-resistant staphylococcus aureus (mrsa)) in a patient in need thereof. In ...
Formulations having anti-inflammatory activity and antimicrobial activity against gram-positive bacteria
Natureza, Inc.
November 23, 2017 - N°20170333379

Novel active compositions having antimicrobial and anti-inflammatory activity are described, the activity provided by an active component prepared in a suspension, the active component being at least a single chain fatty acid having a carbon length of 12, or between 12 and no more than 18. The fatty acid may be esterified and/or ethylated or methylated. As an antimicrobial the active component ...
Topical sodium nitrite formulation
The U.s.a., As Represented By The Secretary, Department Of Health And Human Services
November 23, 2017 - N°20170333345

A sodium nitrite formulation for topical administration is described. The formulation includes an aqueous solution of non-acidified sodium nitrite dispersed in a white petrolatum ointment. The concentration of sodium nitrite in the formulation is about 0. 5% to about 3. 0% by weight. To prepare the formulation, non-acidified sodium nitrite is completely dissolved in a small quantity of water, sterile filtered and dispersed in ...
Hair shaping composition
Conopco, Inc., D/b/a Unilever
November 23, 2017 - N°20170333329

The invention provides a hair shaping composition suitable for topical application to hair, the composition comprising from 1 to 25 wt % monoglucosamine adipate, dissolved or dispersed in an aqueous carrier. The invention also provides a method for improving hair volume-down which comprises the following steps: (i) treating the hair by topical application of the hair shaping composition as defined above; (ii) shaping ...
Method of improving hair volume
Conopco, Inc., D/b/a Unilever
November 23, 2017 - N°20170333328

The invention provides a method for improving the volume of hair which comprises the following steps: (i) treating the hair by topical application of a composition comprising from 1 to 25 wt % of one or more glucosamine salts; (ii) shaping the treated hair; (iii) allowing the composition to remain in contact with the shaped hair before drying. Advantageously the method of the ...
System and method for preventing alopecia
Follea International
November 23, 2017 - N°20170333316

Traction alopecia and other disorders related to mechanical pulling on hair are treated or prevented by administering a topical composition comprising an alpha-1 adrenergic receptor agonist or another compound or electrical stimulation to contract the arrector pili muscle.
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