|| List of recent Topical-related patents
| Optimizing search engine ranking by recommending content including frequently searched questions|
Systems and method of the present invention provide for one or more server computers configured to receive one or more keywords topically relevant to a content of a web page, request from a search engine a first metric comprising a quantity of times the keywords have appeared in a search query with one or more question keywords during a time period and a second metric comprising a probability of receiving a high rank associated with the one or more keywords and the one or more question keywords, receive, from the search engine, the first metric and the second metric, calculate a keyword effectiveness index from the first metric and the second metric, and generate and transmit to a client computer one or more recommendations to include a high ranked suggested content on the web page according to the keyword effectiveness index.. .
| Topical ubiquinol supplement skin care compositions|
Topical, ubiquinol supplement compositions useful for treating skin by: reducing oxidative stress, adjunctively restoring “local” ubiquinol levels, revitalizing aged and/or u.v. Damaged skin and regulating immune responses, including responses to inflammatory challenges; comprising: stabilized ubiquinol supplement, an emulsion of polydimethylsiloxane in a nonionic surfactant and skin penetrants..
| Composition comprising angiotensin ii receptor antagonist and antioxidant for maintaining and/or improving skin properties|
The present invention relates to a topical composition comprising at least one angiotensin ii receptor antagonist and at least one antioxidant.. .
| Treatment and prevention of mastitis|
Treating and preventing mastitis employing cationic steroidal antimicrobials (csas). Treating or preventing clinical mastitis in a mammal includes administering a cationic steroidal anti-microbial compound (csa) formulation to the intra-mammary organ of a mammal (e.g., a dairy cow), such as by injection into the mammary organ (e.g., through the teat of the mammary organ), and/or topical application.
| Salicylic acid topical formulation|
Topical skin treatment formulation containing salicylic acid or a derivative thereof, dissolved in a solvent system comprising (i) dimethyl isosorbide; (ii) a c1 to c9 alkyl salicylate; and (iii) a glyceryl fatty acid ester. The solvent system may also comprise an alcohol, a polyoxyalkylene-based solvent, and/or a c1 to c4 alkyl glucose ester.
| Methods of manufacturing topical compositions and apparatus for the same|
Provided according to some embodiments of the invention are methods of manufacturing a pharmaceutical composition. In some embodiments, such methods include homogenizing at a first excipient composition that includes a viscosity agent and at least one solvent to form a first premix composition; separately homogenizing at least one active pharmaceutical ingredient (api) and a second excipient composition to form a second premix composition; and combining the first premix composition and the second premix composition to form the composition.
| Topical compositions|
Provided herein are anhydrous compositions that include at least one viscosity increasing agent, at least one organic solvent and at least one humectant. Such compositions may also include at least one active pharmaceutical ingredient (api) and/or at least one water repellant.
| Topical use of levofloxacin for reducing lung inflammation|
The present invention relates to methods and compositions for the treatment of pulmonary inflammation. In particular, methods and compositions using aerosol levofloxacin or ofloxacin to reduce pulmonary inflammation are provided..
| Stabilized composition and method for dermatological treatment|
A stabilized, topical composition for the treatment of acne and other dermatological conditions comprises a liposomal formulation of a retinoid and an antibiotic in which the retinoid is disposed in the lipid phase of the formulation, and the antibiotic is disposed in the aqueous phase so as to be isolated from the retinoid. Lincosamides, such as clindamycin, are one group of antibiotics which may be used in the composition.
| Topical nitric oxide systems and methods of use thereof|
The present invention generally relates to compositions and methods for transdermal drug delivery. The compositions can be used in a variety of applications, including treating erectile dysfunction or sexual dysfunction, treating wounds, or causing or promoting hair growth.
| Topical ubiquinol oral supplement compositions with amorphous calcium phosphate|
Topical, ubiquinol, adjunctive, supplement compositions, containing amorphous calcium phosphate fluoride (acpf), useful in: reducing oxidative stress, relieving oral discomfort and dry mouth, and remineralizing hydroxyapatite; comprising: ubiquinol in an aqueous-free emulsion that also contains: a stabilizing composition for ubiquinol, spilanthes extract, a trans-oral mucosal, absorption facilitator and acpf; wherein: the emulsion forms a mucoadhesive gel in the presence of saliva that undergoes gradual saliva dissolution effecting passive diffusion of the ubiquinol supplement and the spilanthes extract into the oral mucosa, and remineralizing of tooth surfaces with acpf; resulting in: adjunctively increasing ubiquinol levels, reducing oxidative stress, regulating immune response, relieving oral discomfort and dry mouth, and remineralizing tooth surfaces.. .
| Material and method for treating internal cavities|
Disclosed herein are materials, means and methods for sustained release of therapeutic agents for topical treatments. In particular, disclosed are means and methods for topical treatment of diseases of internal body cavities by embedding therapeutic agents in a slowly degrading biocompatible mixture applied to affected tissue..
|Selecting user accounts in social network to answer question|
Messages generated by user accounts in a social networking application over a period of time are processed to determine the subjects and topic associated with the messages, as well as the geographical locations of the users associated with the user accounts, and the times when the users associated with the accounts are most active. The determined, subject, time, and location information is used to create a model that may be used to predict whether a user in the social networking application is willing, available, and has the knowledge or topical affinity to answer a question proposed by another user in the social networking application based on a subject, time, and/or location associated with the question.
|Personal care cleaning article|
The present invention provides personal cleaning articles useful for cleaning and/or exfoliating the skin. These articles provide multiple distinct patterns of relatively smooth and coarse elements to provide a user the ability to readily achieve the desired degree of cleansing and/or exfoliation.
|Electrode sensor kit, electrode assembly, and topical preparation for establishing electrical contact with skin, use thereof, and method of electro-impedance tomography (eit) imaging using these|
An electrode sensor kit for establishing electrical contact with skin comprises at least one contact element and a preparation comprising a mixture of water and at least one lipid for enhancing electrical contact properties between said contact element and the skin, wherein said mixture forms an emulsion, in particular a water-in-oil or an oil-in-water emulsion, having a conductivity of less than 3 ms/cm. An electrode assembly for electrical impedance tomography which comprises said kit is characterized in that (a) said at least one contact element forms an electrode or sensor plate, and (b) said at least one contact element comprises a layer of said preparation..
|Foaming topical antimicrobial cleaning compositions|
Provided are largely aqueous topical antimicrobial cleaning composition which provides an antimicrobial benefit, as well as methods for their production and methods for their use. The compositions comprise at least two different cationic surfactants which provide a primary antimicrobial benefit, and as a predominant further surfactant an amine oxide surfactant.
|Combination treatment for rosacea|
The invention relates to a method of treating erythema and/or telangiectasia associated with rosacea in a patient in need thereof by topically administering an effective amount of a combination of brimonidine or a pharmaceutically acceptable salt thereof and oxymetazoline or a pharmaceutically acceptable salt thereof to the site of erythema and/or telangiectasia on the skin of the patient. The invention further relates to topical compositions including the combination of compounds and a pharmaceutically acceptable carrier..
|Topical pharmaceutical composition containing a water-sensitive active principle|
A topical pharmaceutical composition including, as a pharmaceutical active agent, a water-sensitive compound in a solubilised form in a physiologically acceptable medium is described. A method for preparing such a composition, and uses thereof in dermatology are also described..
|Topical pharmaceutical composition based on semifluorinated alkanes|
The invention provides liquid or semi-solid pharmaceutical compositions for topical administration comprising a semifluorinated alkane. The compositions are useful for the delivery of active ingredients into the deep layers of the skin or skin appendages.
|Topical anti-inflammatory combination|
Provided, among other things, is a method of treating or ameliorating an indication of non-mucosal topical tissue comprising periodically applying to such disease affected tissue a composition comprising: an effective amount of an appropriate composition of herbal bioactive comprising active(s) of one or more of sambucus nigra, centella asiatica or echinacea purpurea, and an effective amount of a quaternary ammonium surfactant.. .
|Topical dermal formulations|
An autologous topical formulation containing conditioned medium obtained from culture of autologous fibroblasts has been developed. Unlike other topical formulations, it is autologous since it is derived solely from cells obtained by the person who is to use the formulation.
|Method and composition for the treatment of moderate to severe keratoconjunctivitis sicca|
The present invention relates to topical ophthalmic compositions for treating or preventing epithelial lesions or ophthalmic disorders, including dry eye or keratoconjunctivitis sicca.. .
|Topically or orally applied aloe, distilled water, sodium chloride, and lysozyme mixture and method of producing the mixture|
A skin and/or oral treatment mixture for treating tattooed or pierced skin such as that resulting from a body piercing, oral piercing, or tattoo procedure includes non-iodized sodium chloride, distilled water, aloe, and lysozyme. The distilled water is preferably a product of vapor or steam distillation.
|Topical skin care formulations comprising plant extracts|
Disclosed is a topical skin composition and corresponding methods for its use that includes an extract from bauhinia glauca, an extract from rhodendron siderophyllum, and an extract from circidiphyllum japonicum.. .
|Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives|
A method for treating hair loss in mammals uses compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives. The compositions can be applied topically to the skin.
|Isotopically labeled cdp-choline and uses thereof|
The present invention provides cdp-choline (citicoline) and any salt thereof comprising at least one isotopically labeled carbon atom directly bonded to at least one deuterium atom, a composition comprising said cdp-choline, uses thereof, methods for diagnosing and evaluating a state, condition, or disease in a subject utilizing cdp-choline of the invention and kits comprising cdp-choline of the invention.. .
Fluid applicators utilizing a cutter and an ampule containing fluids, such as topical adhesives, and methods for safe, sterile, one-time use of fluid applicators for expressing fluids, such as wound sealing adhesives, are provided.. .
|Cosmetic particles that transform from hard to soft particles comprising hydrogenated long-chain triglyceride oils|
Cosmetic particle compositions are provided which are adapted to form hard cosmetic particles that transform to soft cosmetic particles after their incorporation into topical formulations, particularly surfactant-based topical formulations. The composition includes one or more partially or fully hydrogenated triglyceride oils, at least 50% of which have at least 15% by weight fatty acid moieties with carbon chain lengths of c18 or higher.
|Combination treatment for dermatological conditions|
The invention relates to a method of treating dermatological conditions or symptoms associated therewith in a patient in need thereof by topically administering an effective amount of a combination of brimonidine or a pharmaceutically acceptable salt thereof and oxymetazoline or a pharmaceutically acceptable salt thereof to the affected area of skin on the patient. The invention further relates to topical compositions including the combination of compounds and a pharmaceutically acceptable carrier..
|Methods and compositions for safe and effective treatment of erythema|
Improved methods and compositions for safe and effective treatment of erythema or a symptom associated with erythema in a subject are described. The methods involve topically applying to an affected skin area a topical composition comprising about 0.3% to about 10% by weight of brimonidine and a pharmaceutically acceptable carrier..
|Povidone-iodine topical composition|
The present invention relates to a topical pharmaceutical composition comprising povidone-iodine, a tertiary amide, surfactant and coconut oil, useful for killing microbes and treating wounds or sores on the surface of the skin.. .
|Single finger and dual finger medication delivery devices, systems and kits; and methods of using the same|
Embodiments described herein generally relate to improved devices, systems, kits, products and methods related to topical medicament application of measured dosages. The kits and devices can single use and/or disposable for example..
|Isotopically-enriched boron-containing compounds, and methods of making and using same|
An isotopically-enriched, boron-containing compound comprising two or more boron atoms and at least one fluorine atom, wherein at least one of the boron atoms contains a desired isotope of boron in a concentration or ratio greater than a natural abundance concentration or ratio thereof. The compound may have a chemical formula of b2f4.
|Methods and compositions for extending shelf life of plant products|
The invention provides compositions and methods related to selective inhibition of ppo11 and use for improving shelf life of a plant or parts thereof. In accordance with the invention, for example, compositions for topical application to a plant or part thereof, are provided that can reduce browning of the plant or part thereof to extend shelf life..
|Context sensitive user group communications|
A system and method for resolving topically relevant contacts for a user is provided. One example embodiment provides for a method including acts of presenting, within a web page, a communication list with content that is presented to various user based at least in part on the users being associated with another user and the topical content of the web page.
|Searching data storage systems and devices by theme|
The invention teaches systems, methods and devices for searching data storage systems and devices by a topical category known as a theme. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure.
|Apparatus for topical negative pressure therapy|
Apparatus and a method for the provision of topical negative pressure therapy to a wound site are described, the apparatus comprising: vacuum generating means for generating a negative pressure at said wound site said vacuum generating means being operably connected to a dressing at said wound site by aspiration conduit means; pressure sensing conduit means in fluid communication with said aspiration conduit means at a junction adjacent said dressing; first pressure sensing means between said junction and said vacuum generating means; second pressure sensing means operably associated with said pressure sensing conduit means; diagnostic means in communication with said first and second pressure sensing means; and control means in communication with said diagnostic means for controlling pressure in said aspiration and said pressure sensing conduit means.. .
|Topical proprioceptive acl tube and methods of use|
A topical proprioceptive tube and method of use for enhancing performance, reducing the risk of knee injury, or both. The tube includes a flexible sleeve having at least: a hamstring buttress, a knee buttress, or both, wherein the hamstring buttress and the knee buttress are configured to be coupled to the interior of the flexible sleeve such that the hamstring buttress applies pressure to at least a portion of one of the subject's hamstring muscles and the knee buttress applies pressure to at least a portion of the subject's vastus medialis obliquus (vmo) when worn by the subject to provide the desired effect..
|Proprioceptive topical leg gear and methods of use|
A topical leg gear for enhancing performance and reducing the risk of injury. The topical leg gear and kits preferably comprise a flexible sleeve and a lateral foot-ankle buttress, malleolus bone buttresses, and a peroneal longus buttress.
|Intra-operative molecular imaging|
A system for detecting tumor margins includes a topical protease-specific, fluorescence imaging probe that is activatable by enzymatic activation to produce a visually differentiated signal upon topical application to a targeted cancer cell that secretes an enzyme that activates the protease-specific, fluorescence imaging probe, means for topically administering the imaging probe to the cancer cell; and an imaging device to detect activation of the imaging probe administered to the cancer cell.. .
Aqueous compositions suitable for topical administration to the human or animal eye contain at least one water-soluble polymeric ophthalmic lubricant, such as hyaluronate, carbomer gel or hypromellose, together with a water-soluble analgesic. The analgesic may be an opiod, particularly an opioid having an affinity for 5-ht receptors, such as tramadol.
|Topical ketoprofen composition|
A topical composition, specifically an oil-in-water emulsion, comprised of ketoprofen and oxybenzone in a physiologically acceptable topical carrier. The composition is applied topically to alleviate pain, especially pain associated with migraine headache.
|Pharmaceutical composition for topical application|
A pharmaceutical composition comprises a solution having a ph of from 5 to 7.5, including loratadine and/or desloratadine. The composition is suitable for treatment of e.g.
|Method and apparatus for vitamin d enhancement in mushrooms|
An apparatus and method for increasing vitamin d content in mushrooms is disclosed. A mushroom slurry of comminuted or pulverized mushrooms or mushroom parts and liquid, such as water, is passed under a uv light source and subjected to one or more pulses of uv light.
|Pharmaceutical compositions and topical use thereof|
The present invention relates to methods for the preparation of compositions comprising adipose tissue-derived secretions, for example those derived from bovine adipose tissue, and the use of such compositions in the preparation of a pharmaceutical composition for topical use. The invention also relates to the use of adipose tissue-derived secretions and pharmaceutical compositions thereof for the topical treatment of a non-inflammatory condition, for example the treatment of a skin condition, and for the stimulation of hair growth in a subject by topical application.
|Treatment of erectile dysfunction and other indications|
The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment.
Provided is a method of treating aged skin, comprising topically applying to the aged skin a composition comprising a compound of formula (i) in an amount effective to provide an anti-ageing effect. The compound of formula (i) is used to prevent skin and/or to help to maintain or improve moisture retention and/or to fight against the signs of skin ageing.
|New i-arylpiperazinic ligands of 5-ht7 receptor and use thereof|
The invention relates to a new class of compounds able to inhibit with high affinity and selectivity the 5-ht7 receptor. The invention also relates to the utilization of such compounds as medicaments useful in the treatment and prevention of 5-ht7 receptor relating disorders of the central nervous system.
|Semantic ranking using a forward index|
Methods, computer systems, and computer-readable media for generating semantic ranking features using a forward index are provided. A search query is received and is analyzed for one or more semantic units including semantic patterns, topical categories, and entities.
|Polymeric adhesive matrix with salified carboxylic groups for transdermal use|
Polymeric matrices for the controlled release of medicaments for the topical transdermal use comprising copolymers of acrylic and/or methacrylic acid or esters thereof having a tg lower than 0.degree. C., whose free carboxy groups are salified with compatible organic or inorganic bases.
|Use of allopurinol for the treatment of hand foot skin reaction|
Use of allopurinol or a pharmaceutically acceptable salt thereof for the treatment or prevention of hand foot skin reaction (hfsr) induced by multitargeted kinase inhibitor (mki) therapy. The allopurinol or its salt is administered topically to the affected areas, palms and soles, preferably in the form of a cream..
|Methods and compositions for treating or preventing erythema|
Methods and products for treating or preventing erythema or a symptom associated with erythema in a subject are described. The methods involve topically applying to an affected skin area a topical aqueous gel composition comprising about 0.01% to about 10% by weight of at least one α-adrenergic receptor agonist and a pharmaceutically acceptable carrier..
|Compositions for stimulating hair growth and preventing hair loss|
A composition for promoting hair growth, slowing hair loss, and for preventing or minimizing hair loss that do not suffer from the deficiencies of the prior art. One exemplary embodiment is directed to a topical formulation for hair, the formulation combining arnica and aqua ammonia to promote hair growth and hair loss diminution..
|Compositions and methods for treatment of infections|
This invention relates to the field of topical treatments for infections such as nail infections, particularly fungal infections of the nail commonly referred to as onychomycosis. Particularly, the invention relates to novel compositions containing peroxide for the treatment of such nail infections and other infections..
|Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system|
The present invention generally relates to compositions and methods for treatment of subjects having or at risk of acne or other conditions. In some cases, the composition may include nitric oxide.
|Even deposition and low rub-off compositions|
Improved deposition and low rub-off compositions are described. The compositions are emulsions with aqueous-based film-forming resins in the water phase and particle with hydrophobic material in the oil phase of the emulsion.
|Topical compositions and methods of use|
Compositions and methods of treatment are disclosed using compositions of extracts from the fruit of the synsepalum dulcificum tree, which when applied topically in mammals, can provide benefit for dermatological and joint conditions. The extracts also contain anti-inflammatory, antimicrobial and spermicidal activity in vitro..
|Compositions for enhancing nail health|
The present invention is directed to compositions and methods for enhancing the health of nails and cuticles in a mammal, including humans. The compositions may be administered topically to the nail bed, nail matrix and cuticle in an amount effective to enhance nail health.
|System for social care routing, prioritization and agent assistance|
A system for social care routing, prioritization and agent assistance for interfacing with a carrier network, a social listening device, a social network or proprietary social feedback apparatus, and a contact center and contact center database. Author postings, demographic information, sentiment, topical relevancy, and customer service requests and other data are used for prioritization, agent assistance and routing.
|Dressings with a foamed adhesive layer|
A dressing suitable for topical application to the body, including a carrier substrate having a first side and opposing second side; and a layer of a foamed adhesive composition applied to the second side of the carrier substrate, where the layer of foamed adhesive composition includes a substantially homogeneous distribution of closed cells having an inert gas contained therein.. .
|Delivery of ibuprofen and other compounds|
The present invention generally relates to the transdermal delivery of various compositions. In some aspects, the transdermal delivery may be facilitated by the use of a hostile biophysical environment.
|Treatment for vitiligo|
Compounds i and ii, as well as prodrugs, hydrates, solvates, n-oxides, salts and pharmaceutical compositions containing them, are useful for treating vitiligo. In certain embodiments, the compounds are provided in topical compositions..
|Isotopically enriched arylsulfonamide ccr3 antagonists|
Provided herein are isotopically enriched arylsulfonamides, for example, of formula i, that are useful for modulating ccr3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a ccr3-mediated disease, disorder, or condition..
|Treatment of psoriasis|
A lipid layer forming composition for topical treatment of psoriasis comprises volatile silicone oil, polar lipid, c2-c4 aliphatic alcohol, and a pharmacologically effective amount of an agent for the treatment of psoriasis, wherein the silicone oil has a boiling point above 180° c., in particular above 200° c. The composition does not comprise polymer silicone.
|Topical formulation for treatment of hyperkeratotic skin|
The present invention relates in general to topical compositions having improved antimicrobial effect useful for the treatment of hyperkeratotic skin conditions. More specifically, the present invention relates to topical compositions comprising a combination of one or more alfa-hydroxy acids, urea, glycerol, and panthenol, as well as the use of such compositions for the treatment of hyperkeratotic skin conditions, in particular on the feet, and also on other body areas where thick skin is noted and where infections should be avoided..
|Transdermal delivery system kit|
A transdermal delivery kit that enhances the efficacy of a topical drug includes at least one drug dispensing device, a lipophilic base, a hydrophilic base, a lipid-soluble active ingredient, a water-soluble active ingredient, a first container for mixing the lipophilic base with the lipid-soluble active ingredient to form a first compound, a second container for mixing the hydrophilic base with the water-soluble active ingredient to form a second compound, a mixing member, and instructions for compounding the lipophilic base with the lipid-soluble active ingredient to form the first compound, compounding the hydrophilic base with the water-soluble active ingredient to form the second compound, and mixing the first compound and the second compound to form a transdermal pharmaceutical delivery system capable of delivering a drug to the dermal layer of the skin.. .
|Camel milk-based topical pharmaceutical composition|
The present invention relates to a novel pharmaceutical composition with milk of immunized camelid, particularly camelus dromedarius as the main component (i.e. Active ingredient) and a method for the treatment or prevention of skin or mucus membrane infections, particularly acne vulgaris.
|Topical delivery of l-arginine to cause beneficial effects|
A preparation is disclosed for producing enhanced blood flow in tissue thus causing beneficial effects such as promoting hair growth on scalp tissuelacking sufficient hair, restoring normal sexual function in males with erectile dysfunction. Specifically, this is a preparation which provides local delivery of the amino acid l-arginine, an important biological precursor to the main substance which is responsible for relaxation of blood vessels permitting enhancement of blood flow.
A system and method for a computer implemented display of information organizes a visual screen display to a user in such a way that the user is able to efficiently select information content, and then be presented with topical associations relating to that content. The display enables selection of a particular information segment having an association with particular information content.
|Predicting content performance with interest data|
Systems and methods for predicting content performance with interest data include receiving a content selection request that includes a client identifier. One or more topical interest categories associated with the client identifier may be used as inputs to a prediction model to predict the likelihood of an online action occurring as a result of third-party content being selected.
|System and method for context enhanced mapping|
A system and method for context enhanced mapping. A request is received from a user over a network for a map comprising an identification of a physical location, and at least one criteria.