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Therapeutics

Therapeutics-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Nmr-based metabolite screening platform
President And Fellows Of Harvard College
June 14, 2018 - N°20180164290

Methods that enable one to specifically measure the metabolic product of a particular molecule in relatively few cells, e.g. Primary cells, are described.
Selective surfaces for, and methods of, selecting a population of stem and progenitor cells, and ...
Cellect Biotherapeutics Ltd.
June 14, 2018 - N°20180163173

The present invention discloses selective surfaces, wherein said selective surfaces comprise a biocompatible polymer comprising maleic anhydride molecules and an apoptosis inducing ligand bound to the maleic anhydride molecules. The invention also encompasses devices and kits comprising the selective surface and methods for its production.
Antibodies specific for claudin 6 (cldn6)
Johannes Gutenberg-universitat Mainz
June 14, 2018 - N°20180162938

The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing claudin-6 (cldn6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, ...
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Therapeutics Patent Applications
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  • 307+ full patent PDF documents of Therapeutics-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
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Il-37 variants
Hudson Institute Of Medical Research
June 14, 2018 - N°20180162918

This invention relates to polypeptides, including variants of interleukin-37 (il-37), and related therapeutics and compositions. The invention also relates to the use of the polypeptides and compositions in methods of treating inflammatory diseases or conditions.
211-astatine containing radiotherapeutics for the treatment of cancer
The Trustees Of The University Of Pennsylvania
June 14, 2018 - N°20180162818

Described herein is an alpha-emitting radionuclide, 211at, which has been incorporated into a selective sigma-2 ligand moiety to provide cytotoxic capabilities to a chemical compound. As described herein, a compound of formula (i), wherein r1-r4, m, and n are defined herein, was prepared and utilized in in vitro and in vivo tumor targeting of alpha-emitting sigma-2 ligand in a ...
Treatment of autoimmune diseases with deep brain stimulation
Aleva Neurotherapeutics
June 14, 2018 - N°20180161574

Techniques using electrical stimulation for treating an autoimmune disease by means of an implantable pulse generator and at least one electrode. An electrode lead is surgically implanted in a region of the insular cortex to deliver electrical stimulation.
Therapeutics Patent Pack
Download 307+ patent application PDFs
Therapeutics Patent Applications
Download 307+ Therapeutics-related PDFs
For professional research & prior art discovery
inventor
  • 307+ full patent PDF documents of Therapeutics-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Models, methods and compositions for treating inflammatory bowel disease
Cedars-sinai Medical Center
June 07, 2018 - N°20180156781

The invention provides models of various conditions including but not limited to intestinal inflammation and/or fibrosis, inflammatory bowel disease, colitis, acute colitis, and chronic colitis, and methods of using such models for designing, screening and developing therapeutics for those conditions. The invention also provides methods, compositions, and kits for treating those conditions..
Affinity-based analytical purification of biotherapeutics for bioprocess monitoring
Genzyme Corporation
June 07, 2018 - N°20180155801

The invention as disclosed herein provides a method for purifying a non-antibody protein from solution, comprising a chromatography step wherein the solution is passed over an affinity construct containing an affinity ligand-coupled solid support, wherein the affinity construct is associated with a bioprocess unit operation, and isolating the non-antibody protein from solution.. .
Restoration of the cftr function by splicing modulation
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.
June 07, 2018 - N°20180155723

Provided are oligonucleotides capable of binding to and modulating the splicing of the pre-mrna of the cftr gene, compositions including said oligonucleotides, kits including the compositions, and uses thereof. In particular, the subject matter provides compositions of oligonucleotides useful in methods for suppressing exon skipping optionally in combination with additional cftr therapeutics..
Anti-mif antibodies in the treatment of cancers containing mutant tp53 and/or mutant ras
Baxalta Incorporated
June 07, 2018 - N°20180155419

The present invention pertains to anti-mif antibodies, preferably in combination with cancer therapeutics, i.e. Chemotherapeutic agents, in the treatment of cancers containing mutant tp53 and/or mutant ras..
Sirp polypeptide compositions and methods of use
Ab Initio Biotherapeutics, Inc.
June 07, 2018 - N°20180155405

Provided herein are sirp-gamma, sirp-beta or sirp-beta2 decoy polypeptides for immunotherapy and/or treatment of cancer, anemia, transplant, asthma, allergy, auto-immune disease, and viral infection.. .
Structure-based peptide inhibitors of p53 aggregation as a new approach to cancer therapeutics
The Regents Of The University Of California
June 07, 2018 - N°20180155396

This invention relates, e.g., to an inhibitory peptide or cpp inhibitor which specifically binds to p53 having an aberrant conformation (e.g., is aggregated or misfolded) and inhibits p53 amyloidogenic aggregation or restores proper folding of the misfolded protein. Methods of using the inhibitory peptide or cpp inhibitor (e.g.
Mixed disulfide conjugates of thienopyridine compounds and uses thereof
The Regents Of The University Of Michigan
June 07, 2018 - N°20180155289

This invention is in the field of medicinal chemistry. In particular, the invention relates to mixed disulfide conjugates of thienopyridine compounds, and their use as therapeutics for the treatment, amelioration, and prevention of cardiovascular diseases..
Therapeutics Patent Pack
Download 307+ patent application PDFs
Therapeutics Patent Applications
Download 307+ Therapeutics-related PDFs
For professional research & prior art discovery
inventor
  • 307+ full patent PDF documents of Therapeutics-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Tau modulators and methods and compositions for delivery thereof
The General Hospital Corporation
June 07, 2018 - N°20180153921

The present disclosure is in the field of diagnostics and therapeutics for alzheimer's disease.. .
Engineered bacteria for production and release of therapeutics
Massachusetts Institute Of Technology
May 31, 2018 - N°20180148729

Some embodiments described herein relate to cells which have been genetically engineered to release a polypeptide when a population of the cells reaches a desired density. In some embodiments, the released polypeptide may be a therapeutic polypeptide.
Delivering crispr therapeutics with lipid nanoparticles
Protiva Biotherapeutics, Inc.
May 31, 2018 - N°20180148719

The present invention provides lipid particles comprising therapeutic nucleic acids such as grna that target gene expression.. .
Genome editing vectors
Coda Biotherapeutics, Inc.
May 31, 2018 - N°20180148711

The present invention generally provides hsv-based genome editing vectors, cell-based compositions, and methods of using the same.. .
Methods for accelerated and enhanced cardiac differentiation of ips cells by electrical stimulation
University Of Cincinnati
May 31, 2018 - N°20180148692

Methods of generating cardiomyocytes from induced pluripotent stem cells (ipscs) are provided. More specifically, the present disclosure relates to methods of generating cardiomyocytes from ipscs using electrical stimulation.
Anti-pd-1 antibodies and their uses
Abbvie Biotherapeutics Inc.
May 31, 2018 - N°20180148513

The present disclosure provides novel anti-pd-1 antibodies, compositions including the new antibodies, nucleic acids encoding the antibodies, and methods of making and using the same.. .
Tgf-beta 3 specific antibodies and methods and uses thereof
Ludwig Institute For Cancer Research Ltd.
May 31, 2018 - N°20180148501

Specific binding members, particularly antibodies and fragments thereof, which bind to transforming growth factor beta 3 (tgf-β3) are provided, particularly recognizing human and mouse tgf-β3, particularly antibodies and fragments that do not recognize or bind tgf-β1 or tgf-β2. Particular antibodies are provided which specifically recognize and neutralize tgf-β3.
Toxoid peptides derived from phenol soluble modulin, delta toxin, superantigens, and fusions thereof
Integrated Biotherapeutics, Inc.
May 31, 2018 - N°20180148482

The present disclosure provides immunogenic compositions useful in prevention and treatment of staphylococcus aureus infection. In particular, the disclosure provides delta toxin and phenol-soluble modulin peptides as well as mutants, fragments, variants or derivatives thereof.
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