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Therapeutics

Therapeutics-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Stable heterodimeric antibody design with mutations in the fc domain
Zymeworks Inc.
January 18, 2018 - N°20180016347

The provided scaffolds have heavy chains that are asymmetric in the various domains (e. G. Ch2 and ch3) to accomplish selectivity between the various fc receptors involved in modulating effector function, beyond those achievable with a natural homodimeric (symmetric) fc molecule, and increased stability and purity of the resulting variant fc heterodimers. These novel molecules comprise complexes of heterogeneous components ...
NEW Deuterated tic10
Concert Pharmaceuticals, Inc.
January 18, 2018 - N°20180016277

This invention relates to novel imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one compounds, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions alone or in combination with other therapeutics in the treatment of diseases and conditions that are beneficially treated by administering an inducer of the gene ...
NEW Optogenetic control of endothelial cells
Massachusetts Institute Of Technology
January 18, 2018 - N°20180015296

The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to transport therapeutics across the vascular barrier into tissues such as the brain and the lung, with high spatial and temporal precision, and for controlling vascular properties such as vascular tone, arterial diameter, and vascular growth.
NEW Therapeutics Patent Pack
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Therapeutics Patent Applications
Download 307+ Therapeutics-related PDFs
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inventor
  • 307+ full patent PDF documents of Therapeutics-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Arginase inhibitors and their therapeutic applications
Oncoarendi Therapeutics S.a.
January 11, 2018 - N°20180009830

The inventive compounds are small molecule therapeutics that are potent inhibitors of arginase 1 and arginase 2 activity. The inventions also provides pharmaceutical compositions and methods for using the inventive compounds for treating or preventing a disease or condition associated with arginase activity.
Fatty acids as anti-inflammatory agents
January 11, 2018 - N°20180008580

Where a, b, c, d, e, f, v, w, x, y, ra, ra′, rb, rb′, rc, and rc′ are defined herein. In particular, the compounds of the invention are candidate therapeutics for treating inflammatory conditions.
Copd biomarker signatures
Lineagen, Inc.
January 04, 2018 - N°20180004895

The present invention relates to methods of detecting differentially expressed protein expression indicative of copd in a test sample. The detection of circulating levels of proteins within an identified copd biomarker signature can aid in copd diagnosis and disease monitoring, as well as in the prediction of responses to therapeutics. Evaluation of the biomarker signatures disclosed, or a subset of ...
Therapeutics Patent Pack
Download 307+ patent application PDFs
Therapeutics Patent Applications
Download 307+ Therapeutics-related PDFs
For professional research & prior art discovery
inventor
  • 307+ full patent PDF documents of Therapeutics-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Non-invasive biomarker to identify subject at risk of preterm delivery
Winthrop-university Hospital
January 04, 2018 - N°20180003713

Methods for diagnosis to allow prediction of the likelihood of preterm birth based upon the concentration of lipocalin-type prostaglandin d2 synthase (l-pgds) in cervical vaginal secretions. In addition, specific prostaglandin d2 receptor antagonists may represent novel tocolytic therapeutics.
Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof
Intrexon Corporation
January 04, 2018 - N°20180002719

This invention relates to the field of therapeutics. Most specifically, the invention provides methods of generating conditionally expressing vectors for one or more immuunomodulators under the control of a gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals. These vector may be provided to treat a variety of disorders, e. G., neoplastic ...
Sequence specific and organism specific antimicrobials and related materials and methods
The Regents Of The University Of Colorado, A Body Corporate
January 04, 2018 - N°20180002692

Described herein are rna-based antisense therapeutics to target antibiotic resistant bacteria. The antisense therapeutics disclosed herein can be useful in re-sensitizing drug-resistant bacteria to antibiotics, as well as developing antibiotics that have bactericidal or bacteriostatic effects on the drug-resistant bacteria or are capable of preventing emergence of antibiotic resistance. Also described herein are methods for re-sensitizing a subject to one ...
Method and system for microbiome-derived diagnostics and therapeutics for locomotor system conditions
Ubiome, Inc.
December 28, 2017 - N°20170372027

A method for at least one of characterizing, diagnosing, and treating a locomotor system condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the ...
Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with microbiome functional features
Ubiome, Inc.
December 28, 2017 - N°20170369933

A method for at least one of characterizing, diagnosing, and treating a condition associated with microbiome functional features in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a ...
Microrna combinations for anti-cancer therapeutics
Massachusetts Institute Of Technology
December 28, 2017 - N°20170369878

Described herein are methods and compositions of combinations of micrornas that enhance the sensitivity of cancer cells to chemotherapeutic agents or reduce proliferation of cancer cells. Also described herein are methods for the identification of combinations of micrornas that result in desired effects.
Cyclodextrin-based polymers for delivering the therapeutic agents covalently bound thereto
Cerulean Pharma Inc.
December 28, 2017 - N°20170369651

The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers ...
Therapeutics Patent Pack
Download 307+ patent application PDFs
Therapeutics Patent Applications
Download 307+ Therapeutics-related PDFs
For professional research & prior art discovery
inventor
  • 307+ full patent PDF documents of Therapeutics-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Diagnostics and therapeutics for diseases associated with g-protein coupled receptor adipor2 (adipor2)
Siemens Healthcare Diagnostics Inc.
December 28, 2017 - N°20170368171

The invention provides human adipor2 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. The ...
Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with microbiome taxonomic features
Ubiome, Inc.
December 28, 2017 - N°20170367641

A method for at least one of characterizing, diagnosing, and treating a condition associated with microbiome taxonomic features in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a ...
Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with microbiome taxonomic features
Ubiome, Inc.
December 28, 2017 - N°20170367640

A method for at least one of characterizing, diagnosing, and treating a condition associated with microbiome taxonomic features in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a ...
Methods and products for expressing proteins in cells
Factor Bioscience Inc.
December 21, 2017 - N°20170362612

The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the dna sequence of a ...
Macropinocytosing human anti-cd46 antibodies and targeted cancer therapeutics
The Regents Of The University Of California
December 21, 2017 - N°20170362330

In various embodiments human anti-cd46 antibodies that are internalizing and enter tumor cells via the macropinocytosis pathway are provided, as well as antibody-drug conjugates (adcs) developed from these antibodies for diagnostic and/or therapeutic targeting of cd46-overexpressing tumors.
Small molecule inhibitors of egfr and pi3k
The Regents Of The University Of Michigan
December 21, 2017 - N°20170360788

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinazoline structure or a quinoline structure which function as dual inhibitors of egfr proteins and pi3k proteins, and their use as therapeutics for the treatment of cancer and other diseases.
Method and system for microbiome-derived diagnostics and therapeutics for locomotor system conditions
Ubiome, Inc.
December 14, 2017 - N°20170357768

A method for at least one of characterizing, diagnosing, and treating a locomotor system condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the ...
Method and system for microbiome-derived diagnostics and therapeutics for locomotor system conditions
Ubiome, Inc.
December 14, 2017 - N°20170357767

A method for at least one of characterizing, diagnosing, and treating a locomotor system condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the ...
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