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Therapeutical

Therapeutical-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Nurr1 as a genetic target for treating levodopa-induced dyskinesias in parkinson's disease
Board Of Trustees Of Michigan State University
July 13, 2017 - N°20170198295

Methods of treating movement disorders by reducing the activity of nurr1 are disclosed. These methods are particularly applicable to subjects suffering from parkinson's disease who have either developed levodopa-induced dyskinesia (lid) or are at risk of developing lid. In some aspects, the invention relates to a method for treating a movement disorder in a subject in need thereof, comprising administering ...
Notch binding agents and antagonists and methods of use thereof
Oncomed Pharmaceuticals, Inc.
July 13, 2017 - N°20170198031

The present invention relates to notch-binding agents and notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human notch receptor, such as notch2 and/or notch3, and inhibit tumor growth. The ...
Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivitives
Mayo Foundation For Medical Education And Research
July 13, 2017 - N°20170196999

A method and composition for treating a meningioma in a subject are disclosed. The method includes the step of administering to the subject a therapeutically effective amount of a composition including a cytotoxic agent associated with a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative that accumulates within meningiomas. In one version of the method, the phenylbenzothiazole derivative ...
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Ornithodoros moubata complement inhibitor for use in the treatment of complement-mediated diseases in patients with ...
Volution Immuno Pharmaceuticals Sa
July 13, 2017 - N°20170196936

The present invention relates to methods of treating or preventing a complement-mediated disease and/or disorder in a subject with a complement c5 polymorphism, including administering to a subject in need thereof a therapeutically or prophylactically effective amount of an agent that a) inhibits the classical complement pathway, the alternative complement pathway and the lectin complement pathway; and/or b) ...
Compositions and related methods for treating hyperadrenocorticism
Volution Immuno Pharmaceuticals Sa
July 13, 2017 - N°20170196920

A composition for treating hyperadrenocorticism includes a therapeutically effective amount of a pharmaceutical dosage form including melatonin, lignan, phosphatidylserine, and at least one probiotic organism-containing material. The composition may be used to treat canine cushing's disease, for example.
Compositions and methods of treating diabetic retinopathy
Case Western Reserve University
July 13, 2017 - N°20170196908

A method of treating diabetic retinopathy in a subject in need thereof includes administering to the subject a therapeutically effective amount of one or more agents that act as a trap of reactive aldehydes and/or inhibit diabetes-induced superoxide generation and capillary degeneration regulated by gpcr signaling pathways.
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Download 734+ patent application PDFs
Therapeutical Patent Applications
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inventor
  • 734+ full patent PDF documents of Therapeutical-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Prevention and treatment of non-alcoholic fatty liver disease
Ohio University
July 13, 2017 - N°20170196845

Methods for preventing, treating, and/or reducing the risk of developing non-alcoholic fatty liver disease in a subject in need thereof and pharmaceutical compositions for the prevention or treatment of non-alcoholic fatty liver disease. Methods for inhibiting excessive accumulation of fat in liver tissue. The methods include administering to the subject or contacting the liver tissue with a therapeutically effective ...
Methods of treating age related disorders
Zafgen, Inc.
July 13, 2017 - N°20170196829

The invention generally relates to methods of treating a patient having, and/or at risk of, oxidative distress disorders and/or age-related disorders. The disclosure also generally relates to methods of treating memory impairment or enhancing the cognitive function of a patient in need thereof. Such methods may include administering a therapeutically effective amount of a metap2 inhibitor.
Ketone bodies to protect tissues from damage by ionizing radiation
The Usa As Represented By The Secretary, Department Of Health And Human Services
July 13, 2017 - N°20170196827

Described herein is the surprising discovery that ketone bodies protect cell and tissues from ionizing radiation. Based on this finding, methods of protecting animal tissue and cells from damage caused by radiation exposure are disclosed which include, contacting the tissue with a therapeutically effective amount of an agent including at least one ketone ester, thereby protecting the tissue from radiation ...
Low frequency glatiramer acetate therapy
Yeda Research & Development Co., Ltd.
July 13, 2017 - N°20170196803

A method of alleviating a symptom of relapsing-remitting multiple sclerosis in a human patient suffering from relapsing-remitting multiple sclerosis or a patient who has experienced a first clinical episode and is determined to be at high risk of developing clinically definite multiple sclerosis comprising administering to the human patient three subcutaneous injections of a therapeutically effective dose of glatiramer acetate ...
Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
Hmi Medical Innovations, Llc
July 06, 2017 - N°20170191986

This invention relates to methods of identifying, synthesizing, optimizing and profiling compounds that are inhibitors or activators of proteins, both naturally occurring endogenous proteins as well as certain variant forms of endogenous proteins, and novel methods of identifying such variants. The method accelerates the identification and development of compounds as potential therapeutically effective drugs by simplifying the pharmaceutical discovery and ...
Ex vivo browning of adipose tissue therapy for reversal of obesity and type ii diabetes
The Trustees Of Columbia University In The City Of New York
July 06, 2017 - N°20170191035

Provided are methods, apparatus, pharmaceutical compositions, and kits for treatment of a metabolic condition, including obesity and type 2 diabetes, by administration to a subject of a therapeutically effective amount of a cell or tissue preparation such as brown adipose microtissues or brown adipose tissue directly converted from white adipose tissue. Modified approaches to creating brown adipose tissue involve differentiation of ...
Method for the treatment of multiple sclerosis
The Government Of The United States Of America As Represented By The Secretary Of The Department Of
July 06, 2017 - N°20170190779

A method for treating a subject with multiple sclerosis is disclosed herein. In one embodiment, a method is provided for treating a subject with multiple sclerosis that includes administering to the subject a therapeutically effective amount of an il-21 receptor antagonist, wherein the subject has failed to respond treatment with beta interferon, thereby treating the subject.
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Therapeutical Patent Applications
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  • 734+ full patent PDF documents of Therapeutical-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Modulation of estrogen receptor-related receptor gamma (err gamma) and uses therefor
Salk Institute For Biological Studies
July 06, 2017 - N°20170189485

This application provides methods of increasing vascularization, muscle performance, muscle rehabilitation, and/or mitochondrial activity in subjects in need thereof, by administering a therapeutically effective amount of one or more agents that increases errγ activity to the subject. Such agents can include one or more errγ agonists. In some examples the method does not require that ...
Compositions and methods for treatment of diseases and conditions employing oral administration of sodium pentosan ...
Urigen Pharmaceuticals, Inc.
July 06, 2017 - N°20170189443

The present invention is directed to a pharmaceutical composition comprising: (1) a therapeutically effective quantity of sodium pentosan polysulfate; (2) a quantity of a penetration enhancer sufficient to improve the bioavailability of the sodium pentosan polysulfate; and (3) optionally, a pharmaceutically acceptable carrier and to methods for the oral administration of sodium pentosan polysulfate with improved bioavailability for the treatment of interstitial cystitis ...
Treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes using menthol, linalool ...
Nestec S.a.
July 06, 2017 - N°20170189403

Compositions tor prevention or treatment of non-inflammatory neuronal damage from brain trauma and strokes are provided, and the compositions contain a therapeutically effective amount of a compound selected from the group consisting of menthol, linalool, icilin and combinations thereof. Methods for treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes are also provided, and the methods include ...
Methods and compositions for treating dry eye disease and other eye disorders
Ocugen, Inc.
July 06, 2017 - N°20170189396

The present invention relates to a method for treating a dry eye syndrome using an alpha 2 adrenergic agonist, pharmaceutically acceptable salt thereof or a mixture thereof. In particular, the alpha 2 adrenergic agonist of the invention has a higher alpha 2a agonist activity compared to alpha 2b agonist activity. This invention also relates to an ophthalmic composition comprising a therapeutically effective ...
Method for treating disorders related to complement activation
Case Western Reserve University
July 06, 2017 - N°20170189366

A method for treating or preventing a complement activated t-cell mediated disorder in a subject includes administering a therapeutically effective amount of a pharmaceutical composition to the subject. The pharmaceutical composition includes at least one amidine compound or pharmaceutically acceptable salt.
Methods and compositions for the treatment of seizure-related disorders
Adamas Pharmaceuticals, Inc.
July 06, 2017 - N°20170189342

Compositions and methods are provided for administering a pharmaceutical composition to a human patient. Compositions are administered to a human patient orally, once daily, at a therapeutically effective dose. The pharmaceutical compositions comprise a drug selected from the group consisting of brivaracetam, divalproex, lacosamide, levetiracetam, oxcarbazepine, vigabatrin, and pharmaceutically acceptable salts of any of the foregoing, and at least one ...
Methylated peptides derived from tau protein and their antibodies for diagnosis and therapy of alzheimer's ...
University Of Maryland, Baltimore
June 29, 2017 - N°20170184614

In sporadic alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of alzheimer's disease, which has remained elusive. These assays have been improved by the analysis of relevant post-translational modifications, such as phosphorylation, however ...
Vegf/dll4 binding agents and uses thereof
Oncomed Pharmaceuticals, Inc.
June 29, 2017 - N°20170183406

The present invention relates to vegf-binding agents, dll4-binding agents, vegf/dll4 bispecific binding agents, and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human vegf, antibodies that specifically bind human dll4, and bispecific antibodies that specifically bind human vegf and/or human dll4. The present invention further provides ...
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