Therapeutical

Therapeutical-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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NEW Methods for the treatment of infections and tumors
May 25, 2017 - N°20170146520

Pd-1 antagonists are disclosed that can be used to reduce the expression or activity of pd-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these pd-1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subjects with infections, such as persistent infections can be treated ...
NEW Methods for achieving therapeutically effective doses of anti-cd47 agents
May 25, 2017 - N°20170145096

Methods are provided for treating a subject with a therapeutic dose of anti-cd47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-cd47 agent to the subject.
NEW Marmelin analogs and methods of use in cancer treatment
May 25, 2017 - N°20170144965

A pharmaceutical composition can include: a marmelin analog compound, and a pharmaceutically acceptable carrier having the compound. The compound can be present in a therapeutically effective amount to treat or inhibit a disease state. The disease state can be cancer. The cancer can be selected from brain cancers, head and neck cancers, thyroid cancers, gastrointestinal cancers, esophageal cancers, stomach cancers, ...
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NEW Method for regulating retinal endothelial cell viability
May 25, 2017 - N°20170143652

Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a quinic acid analog. The method may be applied to prevent, treat or cure pathological conditions of retinal endothelial cells associated with radiation retinopathy, diabetic retinopathy and chemotherapy for retinoblastoma.
NEW Composition of olivetol and method of use to reduce or inhibit the effects of tetrahydrocannabinol ...
May 25, 2017 - N°20170143644

Embodiments of the present invention relate to the use of a therapeutically-effective amount of olivetol to reduce, eliminate, inhibit or alleviate the psychoactive effects of thc in users of cannabis. Further embodiments of the present invention relate to a softgel, tablet or capsule of olivetol in combination with an edible oil.
NEW Composition of olivetol and method of use to reduce or inhibit the effects of tetrahydrocannabinol ...
May 25, 2017 - N°20170143643

Embodiments of the present invention relate to the use of a therapeutically-effective amount of olivetol to reduce, eliminate, inhibit or alleviate the psychoactive effects of thc in users of cannabis. Further embodiments of the present invention relate to a softgel, tablet or capsule of olivetol in combination with an edible oil.
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New treatment against influenza virus
Memorial Sloan-kettering Cancer Center
May 18, 2017 - N°20170137824

The present application provides a method for treating an influenza virus infection in a subject characterised in that a therapeutically effective amount of a modulator of the ubiquitin-binding property of hdac6 is administered to said subject. The present application also provides an antibody binding to hdac6 and decreasing or blocking its ubiquitin-binding properties for use in treating an influenza virus ...
Double-stranded oligonucleotides
Life Technologies Corporation
May 18, 2017 - N°20170137816

Antisense sequences, including duplex rnai compositions, which possess improved properties over those taught in the prior art are disclosed. The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically. The invention also provides methods of making and using the improved antisense oligomer compositions.
Organic compositions to treat apoc3-related diseases
Arrowhead Pharmaceuticals, Inc.
May 18, 2017 - N°20170137814

The present disclosure relates to compositions and methods for treating apoc3-related diseases such as: hypertriglyceridemia (e. G., type v hypertriglyceridemia), abnormal lipid metabolism, abnormal cholesterol metabolism, atherosclerosis, hyperlipidemia, diabetes, including type 2 diabetes, obesity, cardiovascular disease, and coronary artery disease, among other disorders relating to abnormal metabolism or otherwise, using a therapeutically effective amount of a rnai agent to apoc3.
Peptides, and methods and apparatus utilising same
The University Of Manchester
May 18, 2017 - N°20170137490

The present invention relates to peptides that are able to bind to anti-pla2r antibodies. The peptides comprise the amino acid sequence k-x1-x2-x3-x4-x5-k-x6-x7-x8-x9-x10-x11-x12-x13-k (seq id no:2), in which both x1 and x13 may be cysteine residues. The peptides may have a length of up to 60 amino acid ...
Boron-based prodrug strategy for increased bioavailability and lower-dosage requirements for drug molecules containing at least ...
Xavier University Of Lousiana
May 18, 2017 - N°20170137443

Boron-based prodrugs of phenol- or aromatic hydroxyl group-containing therapeutic molecules (“original drugs”), uses thereof, and methods of making the same, are provided for achieving, for example, improved bioavailability, prolonged retention (e. G., in a circulatory system) and, in particular, significantly lowered therapeutically effective dosage in order to reduce adverse effects while maintaining the desired therapeutic effects ...
Antiviral drugs for treatment of arenavirus infection
Kineta Four, Llc
May 18, 2017 - N°20170137422

Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by the arenavirus family such as lassa fever, argentine hemorrhagic fever, ...
Compositions and methods for inhibition of the jak pathway
Rigel Pharmaceuticals, Inc.
May 18, 2017 - N°20170137411

Disclosed are compounds of formula i, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the jak pathway or inhibition of jak kinases, particularly jak 2 and jak3, are therapeutically useful.
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Therapeutically applicable multichannel direct current delivery device
Sk Biopharmaceuticals Co., Ltd.
May 18, 2017 - N°20170136235

A direct current delivery device includes a direct current source or a device for connecting to a direct current source, and a first electrode and a second electrode for connecting to the direct current source, wherein the first electrode is configured as a plurality of needles and the second electrode is configured as a planar electrode, as a needle or ...
Non-fouling, anti-microbial catheter
Puratec, Llc
May 18, 2017 - N°20170136210

The disclosed non-fouling, antimicrobial catheters release a therapeutically effective amount of silver ions in response to an electrical current to prevent, inhibit, or reduce bacteria or fungi from passing through the catheter into the body of a subject, for example passing through the urethra and into the bladder via the gap between the external surface of the catheter and the ...
Drug delivery medical device
Micell Technologies, Inc.
May 18, 2017 - N°20170136155

Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or ...
Thioredoxin or thioredoxin derivatives or peptides for the treatment of high blood pressure
Texas Tech University System
May 18, 2017 - N°20170136100

The present invention provides methods and compositions for the treatment of cardiovascular disorders comprising: a therapeutically effective amount of thioredoxin-1 or a thioredoxin-1 derivative in a pharmaceutical carrier to ameliorate one or more symptom of a cardiovascular disorder.
Angiopoietin-based interventions for treating cerebral malaria
University Health Network
May 18, 2017 - N°20170136090

The present invention provides methods for treating, preventing or reducing the severity of cerebral malaria. The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a modified angiopoietin molecule such as angf1-fc-f1.
Topical compositions and methods for treating wounds
University Health Network
May 18, 2017 - N°20170136086

In various embodiments, the present invention relates to a topical pharmaceutical composition for treating a skin condition, comprising a combination of agents, wherein the combination includes: a) one or more antimicrobial compounds; b) one or more trace elements; c) one or more tissue reconstruction elements; and d) one or more analgesics, and a pharmaceutically-acceptable carrier. In certain embodiments, the invention ...
Composition and method for the treatment of neuropathic pain
Neuragen Corp.
May 18, 2017 - N°20170136081

The present invention provides a therapeutically effective composition and method of treatment of neuropathic pain utilizing extracts of monarda, for example, monarda fistulosa and related species, used alone or in a composition with a pharmaceutically acceptable carrier in a suitable dosage form.
Il-12 immunotherapy for cancer
University Health Network
May 18, 2017 - N°20170136072

Compositions and methods far delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as leukemia.