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|| List of recent Tetrabenazine-related patents
The present invention provides for a pharmaceutical composition that includes tetrabenazine and a release-retarding agent; and a method of treating a hyperkinetic movement disorder (e.g., huntington's disease, chorea associated with huntington's disease, hemiballismus, senile chorea, tic disorders, tardive dyskinesia, myoclonus, dystonia and/or tourette's syndrome). The method includes administering an effective amount of the pharmaceutical composition, for a period of time effective to treat the hyperkinetic movement disorder..
|Pharmaceutical compositions for combination therapy|
This invention relates to novel pharmaceutical compositions comprising a therapeutically effective combination of a dopaminergic stabilizer known as pridopidine, and an inhibitor of the vesicular monoamine transporter type 2 (vmat) known as tetrabenazine. The pharmaceutical compositions for use according to the invention are contemplated particularly useful for improving the symptomatic therapeutic effects, and for reducing the adverse effects, of tetrabenazine in the treatment of movement disorders, and in particular movement disorders associated with huntington's disease, gilles de la tourette's syndrome, or tardive dyskinesia..
|Method of preparing tetrabenazine and dihydrotetrabenazine|
The present invention relates to a method for preparing tetrabenazine (tbz) and dihydrotetrabenazine (dtbz), and more specifically to a method for preparing tetrabenazine (tbz) and dihydrotetrabenazine (dtbz) by using simple and short reaction processes of using 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 4-methyl-2-(3-(trimethylsilyl)prop-1-ene-2-yl)pentane as starting materials to sequentially perform an alkylation reaction, an aza-prins cyclization reaction in the presence of an oxidant and an oxidation reaction.. .
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Tetrabenazine topics: Tetrabenazine, Movement Disorder, Therapeutical, Dyskinesia, Combination Therapy, Adverse Effect, Movement Disorders, Tardive Dyskinesia, Isoquinolin, Alkylation
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