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Stimulator patents

      

This page is updated frequently with new Stimulator-related patent applications.




 Apparatus and  implantable bidirectional wireless neural recording and stimulation patent thumbnailApparatus and implantable bidirectional wireless neural recording and stimulation
A device and method is described for electronic human prosthetics, and specifically a skull- and/or spine implantable bi-directional neural-communication/brain-machine interface (bbmi) device where the input, output and on-board computing are combined into a single unit to form a compact neuro-prosthetics device. This invention is also directed to a fully implantable wireless spinal electronic recording and stimulation system using the bbmi in a human.
The San Diego University Research Foundation


 Bispecific chimeric antigen receptors and encoding polynucleotides thereof patent thumbnailBispecific chimeric antigen receptors and encoding polynucleotides thereof
The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain fv (scfv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors..
Seattle Children's Hospital D/b/a Seattle Children's Research Institute


 Frequency stimulator patent thumbnailFrequency stimulator
In some cases, a frequency stimulator that can control a dosage of impulses of various low frequencies of electromagnetic waves, uses a cell phone, a tablet, a laptop, and/or any other suitable devices that produce frequencies and can supply an inductive coil that is installed in a headband of the frequency stimulator in a way to produce a low frequency electromagnetic field with the basic purpose of achieving a positive response to the frequency of the human brain that responds to a programed frequency and adjusts to it, thus creating various states of consciousness in the human head. In some cases, the power source is connected to the headband in which there is the induction coil.

 User interface for neurostimulation waveform composition patent thumbnailUser interface for neurostimulation waveform composition
An example of a system for programming a neurostimulator may include a storage device and a user interface. The storage device may be configured to store waveform building blocks.
Boston Scientific Neuromodulation Corporation


 Integration of neurostimulator programming modes patent thumbnailIntegration of neurostimulator programming modes
A system and method for programming a neurostimulation device coupled to a plurality of electrodes implanted adjacent tissue of a patient are provided. A first electrode configuration corresponding to a first mode of programming the neurostimulation device is defined.
Boston Scientific Neuromodulation Corporation


 System and  treating obstructive sleep apnea patent thumbnailSystem and treating obstructive sleep apnea
One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source.
The Cleveland Clinic Foundation


 Clitoral stimulator patent thumbnailClitoral stimulator
A clitoral stimulator features first and second contact members, at least one of which is supported for back and forth movement relative to the other of said first and second contact members in a longitudinal direction. Each contact member has a respective contact surface on side thereof facing toward the other in a lateral direction lying transverse to the longitudinal direction.
7417986 Manitoba Inc.


 Bio-impedance measurement method using bi-phasic current stimulus excitation for implantable stimulator patent thumbnailBio-impedance measurement method using bi-phasic current stimulus excitation for implantable stimulator
Method and apparatus for estimating bio-impedance at electrode-electrolyte interface by injecting a single low-intensity bi-phasic current stimulus having an selected inter-pulse delay first and second current pulse phases, which involves acquiring transient electrode voltage along the bi-phasic current stimulus waveform. Determining equivalent circuit parameters of an electrode, at the electrode-electrolyte/tissue interface, based on transient electrode voltage across said multiple temporal locations is also performed..
The Regents Of The University Of California


 6-chlorine-substituted imidazo[1,2-a]pyridine carboxamides and the use thereof as soluble guanylate cyclase stimulators patent thumbnail6-chlorine-substituted imidazo[1,2-a]pyridine carboxamides and the use thereof as soluble guanylate cyclase stimulators
The present application relates to novel 6-chloro-substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.. .
Bayer Pharma Aktiengesellschaft


 Implantable neurostimulator-implemented  managing techyarrhythmia through vagus nerve stimulation patent thumbnailImplantable neurostimulator-implemented managing techyarrhythmia through vagus nerve stimulation
An implantable neurostimulator-implemented method for managing tachyarrhythmias through vagus nerve stimulation is provided. An implantable neurostimulator, including a pulse generator, is configured to deliver electrical therapeutic stimulation in a manner that results in creation and propagation (in both afferent and efferent directions) of action potentials within neuronal fibers of a patient's cervical vagus nerve.
Cyberonics, Inc.


Beta-glucan in combination with anti-cancer agents affecting the tumor microenvironment

The present invention relates to the combination of soluble β-glucan and anti-cancer agents that affect the tumor microenvironment. Soluble β-glucan promotes an immunostimulatory environment, which allows enhanced effectiveness of anti-cancer agents..
Biothera, Inc.

Beta-glucan methods and compositions that affect the tumor microenvironment

This disclosure relates to the combination of soluble β-glucan and immune suppression-relieving agents that affect the tumor microenvironment. Soluble β-glucan promotes an immunostimulatory environment, which allows enhanced effectiveness of anti-angiogenics, checkpoint inhibitors including non-tumor targeting antibodies..
Biothera, Inc.

Cell based assay to measure the t-cell stimulating capacity of anti-lag3 antibodies and other agents

The present invention includes a human lag3 functional assay using a jurkat t-cell lymphoma cell line engineered to overexpress lag3 at an optimal level relative to cd3. The assay is useful, for example, for determining the immunostimulatory properties of lag3 modulators (e.g., inhibitors or activators).
Merck Sharp & Dohme Corp.

Mature dendritic cell compositions and methods for culturing same

This invention provides methods to prepare and use immunostimulatory cells for enhancing an immune response. The invention provides a method for preparing mature dendritic cells (dcs), comprising the sequential steps of: (a) signaling isolated immature dendritic cells (idcs) with a first signal comprising an interferon gamma receptor (ifn-γr) agonist and/or a tumor necrosis factor alpha receptor (tnf-αr) agonist to produce signaled dendritic cells; and (b) signaling said signaled dendritic cells with a second transient signal comprising an effective amount of a cd40 agonist to produce ccr7+ mature dendritic cells.
Argos Therapeutics, Inc.

Mature dendritic cell compositions and methods for culturing same

This invention provides methods to prepare and use immunostimulatory cells for enhancing an immune response. The invention provides a method for preparing mature dendritic cells (dcs), comprising the sequential steps of: (a) signaling isolated immature dendritic cells (idcs) with a first signal comprising an interferon gamma receptor (ifn-γr) agonist and/or a tumor necrosis factor alpha receptor (tnf-αr) agonist to produce signaled dendritic cells; and (b) signaling said signaled dendritic cells with a second transient signal comprising an effective amount of a cd40 agonist to produce ccr7+ mature dendritic cells.
Argos Therapeutics, Inc.

Spinal catheter having multiple obstruction-clearing features

A spinal catheter for insertion into the epidural space of a human or animal subject includes first and second lumens. A pressurized fluid can be discharged through the first lumen directly onto a tissue obstruction to form a partial/pilot or full/final opening in the tissue obstruction.

Antimicrobial articles produced by additive manufacturing

An antibiotic-eluting article for implantation into a mammalian subject, produced by an additive manufacturing process wherein a polymeric material is concurrently deposited with a selected antibiotic. The additive manufacturing process may be a selective laser sintering process or a selective laser melting process or a selective heat sintering process or an electron beam melting process.
Orthopaedic Innovation Centre

Compositions and methods for adjoining type i and type ii extracellular domains as heterologous chimeric proteins

The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity. In part, the invention provides, in various embodiments, fusions of extracellular domains of transmembrane proteins that can have stimulatory or inhibitory effects..
Heat Biologics, Inc.

Technique for linking electrodes together during programming of neurostimulation system

An external control device for use with a neurostimulator coupled to a plurality of electrodes capable of conveying electrical stimulation energy into tissue in which the electrodes are implanted. The external control device comprises a user interface including at least one control element, a processor configured for independently assigning stimulation amplitude values to a first set of the electrodes, for linking the first set of electrodes together in response to the actuation of the at least one control element, and for preventing the stimulation amplitude values of the first linked set of electrodes from being varied relative to each other, and output circuitry configured for transmitting the stimulation amplitude values to the neurostimulator..
Boston Scientific Neuromodulation Corporation

Transcutaneous electrostimulator and methods for electric stimulation

An electrostimulation device includes a computer generating an electrostimulation generator control signal and outputting a music signal, a transcutaneous electrostimulation generator, an electronic signal conduit, and an electrode coupler. The generator receives the generator control signal and the music signal, generates a nerve electrostimulation signal dependent upon the generator control signal, and outputs the nerve electrostimulation signal at the stimulation output and the music signal at an audio output.
Nervana, Llc

Wireless implantable taste system

The system includes various embodiments of components, including (1) a sensor array, (2) a processor, (3) a transmitter, (4) a receiver-stimulator, and (5) an implantable electrode array. The gustatory implant system generates tastant fingerprints by detecting tastants with an array of chemical sensors and then transmitting variable spatiotemporal stimulation patterns for an electrode array with electrode stimulating points positioned at different locations in the gustatory cortex (e.g., stimulating the chorda tympanic nerve).
Virginia Commonwealth University

Neural stimulation to treat sleep apnea

A removable oral device is disclosed. The removable oral device comprises a mounting retainer configured to align with a set of teeth.
Medtronic, Inc.

Naturally-occurring cpg oligonucleotide compositions and therapeutic applications thereof

The present invention relates to combination therapies for the treatment of a variety of disorders in mammals, including hepatic disorders and cancer. The combination of agents includes naturally-occurring (versus synthetic) oligonucleotides, particularly immunostimulatory oligodeoxynucleotides such as cpg odns, obtained from a natural source and one or more extracts from a gram positive bacteria, such as lactobacillus spp..
Labyrinth Holdings, Llc

Systems, devices, and methods for electric power generation from vocal folds vibrations

Apparatus and methods are provided for the generation of electrical power from acousto-mechanical vibrations originating from the vocal folds of the human body. The apparatus and methods can include one or more beams comprising a piezoelectric material, such as lead zirconate titanate (pzt), coupled to a power circuitry.

Regulatable chimeric antigen receptor

Provided are compositions and methods relating to regulatable chimeric antigen receptors (rcars), natural killer cell receptor cars (nkr-cars), and regulatable nkr-cars (rnkr-cars), where the intracellular signaling or proliferation of the rcar or rnkr-car can be controlled to optimize the use of an rcar/nkr-car- or rnkr-car-expressing cell to provide an immune response. Cells can be engineered to express a rnkr-car or to express a rcar and a nkr-car (e.g., inhibitory nkr-car).
The Trustees Of The University Of Pennsylvania

Generation of brain and spinal cord neurons, cardiac myocytes, renal nephrons and hepatocytes using reg peptides, peptidomimetics, small molecules and stimulatory antibodies to reg receptor

Peptides that are bioactive regions and optimized bioactive regions of the human and mammalian reg gene proteins and that are capable of generation of tissues such as brain, spinal cord, heart, liver, and kidney are described. In particular, 7-15-amino acid reg peptides and optimized reg peptides are disclosed which are capable of in vivo and ex vivo transformation of progenitor cells, progenitor tissue and stem cells into specialized cells and tissues, including functioning brain and spinal cord neurons, cardiac myocytes, liver hepatocytes and renal nephrons.

Systems and methods for increasing a delay in the gastric emptying time for a patient using a transcutaneous electro-dermal patch

The disclosed wearable device modulates a patient's gastric emptying time and/or gastric retention time. The wearable device includes a microprocessor, electrical stimulator and at least one electrode configured to deliver electrical stimulation to the epidermis, through a range of 0.1 mm to 10 mm or a range of 0.1 mm to 20 mm of the dermis, of a t2 dermatome to a t12 dermatome or meridian of the patient, a c5 to a t1 dermatome across the hand and/or arm, and/or the upper chest regions.
Elira, Inc.

Apparatuses and methods for auto-replenishment of electrodes for transdermal electrical stimulation

Described herein are methods for automatically reordering, resupplying, or replenishing tes electrode apparatus units (“electrodes”) for use with a wearable neurostimulator.. .

Individualized cancer therapy

In certain preferred embodiments, the invention provides methods for treating cancer, which comprise (a) obtaining a specimen of cancer tissue from a patient; (b) obtaining a specimen of normal tissue in the proximity of the cancer tissue from such patient; (c) extracting total protein and rna from the cancer tissue and normal tissue; (d) obtaining a protein expression profile of the cancer tissue and normal tissue using 2d dige and mass spectrometry; (e) identifying proteins that are expressed in such cancer tissue at significantly different levels than in the normal tissue; (f) obtaining a gene expression profile of the cancer tissue and normal tissue using microarray technology and comparing the results thereof to the protein expression profile; (g) prioritizing over-expressed proteins by assessing the connectivity thereof to other cancer-related or stimulatory proteins; (h) designing an appropriate rna interference expression cassette to, directly or indirectly, modulate the expression of genes encoding such prioritized proteins; (i) incorporating said cassette into an appropriate delivery vehicle; and (j) providing the patient with an effective amount of the delivery vehicle to directly or indirectly, modify the expression (i.e., production) of such proteins.. .
Gradalis, Inc.

Neurostimulator system, apparatus, and method

An apparatus (10) for applying stimulation therapy to a patient includes an implantable medical device (20) and a remote controller (50) for inductively powering the medical device and communicating with the medical device. The remote controller (50) includes a feedback portion (220) for helping to establish a communication link between the remote controller and the implantable medical device (20)..
Autonomic Technologies, Inc.

Electric stimulator

An electric stimulator includes a housing, a control circuit board, and at least two electrode plates. The housing includes an internal space formed therein and an outside surface in which at least one electrode plate retention slot is formed.

Lower back electrical stimulator

The electrical stimulation belt includes an electrical stimulator, a flexible substrate, a plurality of electrical connectors, a plurality of electrodes and a plurality of locators. The electrical stimulation is applied to the trunk or waist of a patient by the electrical stimulator belt through the placement of the plurality of electrical connectors in contact with the plurality of electrodes on the belt.
Axiobionics

Immunostimulatory sequence oligonucleotides and methods of using the same

The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides.. .
Dynavax Technologies Corporation

Functional electrical stimulation systems

A gait modulation system including: (a) a sensor device including a sensor adapted for associating with at least one lower limb of the patient, the sensor for transducing at least one parameter related to a gait of the patient, so as to obtain gait data related to the gait, and (b) a muscle stimulator including: (i) an electrical stimulation circuit, the circuit adapted to supply an electrical stimulation output to an electrode array for performing functional electrical stimulation of at least one muscle of the lower limb, and (ii) a microprocessor, operatively connected to the at least one sensor, the microprocessor adapted for: receiving a stream of gait information based on the gait data; processing the gait information, and controlling the stimulation output based on the processing of the gait information, and wherein the microprocessor is further adapted to identify a failure in the stream of gait information, and to consequently control the electrical stimulation circuit to deliver a fail-safe stimulation output over a portion of a duration of the failure.. .
Bioness Neuromodulation Ltd.

Neurostimulator interconnection apparatus, system, and method

In various examples, an apparatus includes a neurostimulation interconnection apparatus including an elongate lead body including a lead proximal end and a lead distal end. The lead proximal end includes a first connector portion.
Greatbatch Ltd.

Uses of starch binding protein (sbp)-tagged immunostimulatory protein

The present invention relates to a method for preventing or treating virus and protozoa infection in a subject in need thereof comprising: orally administering to said subject an effective amount of a composition comprising a complex consisting of a starch binding protein (sbp)-tagged immunostimulatory protein and a sbp-binding matrix, wherein the immunostimulatory protein is from ganoderma species. The present invention also relates to a method for inducing interferon-gamma production in a subject in need thereof comprising: orally administering to said subject an effective amount of a composition comprising a complex consisting of a starch binding protein (sbp)-tagged immunostimulatory protein and a sbp-binding matrix, wherein the immunostimulatory protein is from ganoderma species.
Simpson Biotech Co., Ltd

Sgc stimulators

Wherein ring b, jb, n, jd, j, o, x, rc and ra are as described herein.. .

Hearing prosthesis sound processing

A method may include receiving a sound signal and identifying a plurality of components of the sound signal. The plurality of components may include a tonal component and an atonal component.

Controlled stimulation delivery from neurostimulator

A system for providing neurostimulation includes an external device (“external exciter”) and an implanted device. The external exciter includes an energy source which inductively powers the implanted device.
Arizona Board Of Regents On Behalf Of Arizona State University

Three-dimensional negative pressure stimulator module capable of performing customized composite stimulation for improvement of skin functions

The present invention relates to a three-dimensional negative pressure stimulator module capable of performing customized composite stimulation for the improvement of skin functions that applies three-dimensional negative pressure stimulation as well as composite stimulation such as electric current stimulation, light stimulation, and thermal stimulation, which is helpful in improving functions of the skin, to skin compositively, and further has a function of sensing a skin state, thereby performing customized composite stimulation. The three-dimensional composite stimulator module includes: a negative pressure cup; and at least one diaphragm provided along the transmission path of the negative pressure of the negative pressure cup, wherein at least any one of negative pressure stimulation, light stimulation, thermal stimulation, and electrical stimulation is transmitted compositively to the skin or subcutaneous tissues..
Taeyi Lifescience Inc.

Immunostimulatory anti-ceacam1 antibody

An anti-ceacam1 antibody includes at least one antibody heavy chain (vh) domain having antigen binding sites cdr1h, cdr2h and cdr3h, and at least one antibody light chain (vl) domain having antigen binding sites cdr1l, cdr2l and cdr3l. The antigen binding site cdr2h has a sequence homology of at least 80% to the amino acid sequence wintytgept (seq id no.
Universitaet Duisburg-essen



Stimulator topics:
  • Stimulator
  • Genetically
  • Immune System
  • Immune Response
  • Immunostimulator
  • Nanotechnology
  • Prophylaxis
  • Immunomodulator
  • Hemodynamic
  • Electrical Pulse
  • Dysfunction
  • Vagus Nerve
  • Frequency Band
  • Ion Channel
  • Cochlear Implant


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    This listing is a sample listing of patent applications related to Stimulator for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Stimulator with additional patents listed. Browse our RSS directory or Search for other possible listings.


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