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Stimulator patents

      

This page is updated frequently with new Stimulator-related patent applications.




 Apparatuses and methods for auto-replenishment of electrodes for transdermal electrical stimulation patent thumbnailApparatuses and methods for auto-replenishment of electrodes for transdermal electrical stimulation
Described herein are methods for automatically reordering, resupplying, or replenishing tes electrode apparatus units (“electrodes”) for use with a wearable neurostimulator.. .

 Individualized cancer therapy patent thumbnailIndividualized cancer therapy
In certain preferred embodiments, the invention provides methods for treating cancer, which comprise (a) obtaining a specimen of cancer tissue from a patient; (b) obtaining a specimen of normal tissue in the proximity of the cancer tissue from such patient; (c) extracting total protein and rna from the cancer tissue and normal tissue; (d) obtaining a protein expression profile of the cancer tissue and normal tissue using 2d dige and mass spectrometry; (e) identifying proteins that are expressed in such cancer tissue at significantly different levels than in the normal tissue; (f) obtaining a gene expression profile of the cancer tissue and normal tissue using microarray technology and comparing the results thereof to the protein expression profile; (g) prioritizing over-expressed proteins by assessing the connectivity thereof to other cancer-related or stimulatory proteins; (h) designing an appropriate rna interference expression cassette to, directly or indirectly, modulate the expression of genes encoding such prioritized proteins; (i) incorporating said cassette into an appropriate delivery vehicle; and (j) providing the patient with an effective amount of the delivery vehicle to directly or indirectly, modify the expression (i.e., production) of such proteins.. .
Gradalis, Inc.


 Neurostimulator system, apparatus, and method patent thumbnailNeurostimulator system, apparatus, and method
An apparatus (10) for applying stimulation therapy to a patient includes an implantable medical device (20) and a remote controller (50) for inductively powering the medical device and communicating with the medical device. The remote controller (50) includes a feedback portion (220) for helping to establish a communication link between the remote controller and the implantable medical device (20)..
Autonomic Technologies, Inc.


 Electric stimulator patent thumbnailElectric stimulator
An electric stimulator includes a housing, a control circuit board, and at least two electrode plates. The housing includes an internal space formed therein and an outside surface in which at least one electrode plate retention slot is formed.

 Lower back electrical stimulator patent thumbnailLower back electrical stimulator
The electrical stimulation belt includes an electrical stimulator, a flexible substrate, a plurality of electrical connectors, a plurality of electrodes and a plurality of locators. The electrical stimulation is applied to the trunk or waist of a patient by the electrical stimulator belt through the placement of the plurality of electrical connectors in contact with the plurality of electrodes on the belt.
Axiobionics


 Immunostimulatory sequence oligonucleotides and methods of using the same patent thumbnailImmunostimulatory sequence oligonucleotides and methods of using the same
The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides.. .
Dynavax Technologies Corporation


 Functional electrical stimulation systems patent thumbnailFunctional electrical stimulation systems
A gait modulation system including: (a) a sensor device including a sensor adapted for associating with at least one lower limb of the patient, the sensor for transducing at least one parameter related to a gait of the patient, so as to obtain gait data related to the gait, and (b) a muscle stimulator including: (i) an electrical stimulation circuit, the circuit adapted to supply an electrical stimulation output to an electrode array for performing functional electrical stimulation of at least one muscle of the lower limb, and (ii) a microprocessor, operatively connected to the at least one sensor, the microprocessor adapted for: receiving a stream of gait information based on the gait data; processing the gait information, and controlling the stimulation output based on the processing of the gait information, and wherein the microprocessor is further adapted to identify a failure in the stream of gait information, and to consequently control the electrical stimulation circuit to deliver a fail-safe stimulation output over a portion of a duration of the failure.. .
Bioness Neuromodulation Ltd.


 Neurostimulator interconnection apparatus, system, and method patent thumbnailNeurostimulator interconnection apparatus, system, and method
In various examples, an apparatus includes a neurostimulation interconnection apparatus including an elongate lead body including a lead proximal end and a lead distal end. The lead proximal end includes a first connector portion.
Greatbatch Ltd.


 Uses of starch binding protein (sbp)-tagged immunostimulatory protein patent thumbnailUses of starch binding protein (sbp)-tagged immunostimulatory protein
The present invention relates to a method for preventing or treating virus and protozoa infection in a subject in need thereof comprising: orally administering to said subject an effective amount of a composition comprising a complex consisting of a starch binding protein (sbp)-tagged immunostimulatory protein and a sbp-binding matrix, wherein the immunostimulatory protein is from ganoderma species. The present invention also relates to a method for inducing interferon-gamma production in a subject in need thereof comprising: orally administering to said subject an effective amount of a composition comprising a complex consisting of a starch binding protein (sbp)-tagged immunostimulatory protein and a sbp-binding matrix, wherein the immunostimulatory protein is from ganoderma species.
Simpson Biotech Co., Ltd


 Sgc stimulators patent thumbnailSgc stimulators
Wherein ring b, jb, n, jd, j, o, x, rc and ra are as described herein.. .

Hearing prosthesis sound processing

A method may include receiving a sound signal and identifying a plurality of components of the sound signal. The plurality of components may include a tonal component and an atonal component.

Controlled stimulation delivery from neurostimulator

A system for providing neurostimulation includes an external device (“external exciter”) and an implanted device. The external exciter includes an energy source which inductively powers the implanted device.
Arizona Board Of Regents On Behalf Of Arizona State University

Three-dimensional negative pressure stimulator module capable of performing customized composite stimulation for improvement of skin functions

The present invention relates to a three-dimensional negative pressure stimulator module capable of performing customized composite stimulation for the improvement of skin functions that applies three-dimensional negative pressure stimulation as well as composite stimulation such as electric current stimulation, light stimulation, and thermal stimulation, which is helpful in improving functions of the skin, to skin compositively, and further has a function of sensing a skin state, thereby performing customized composite stimulation. The three-dimensional composite stimulator module includes: a negative pressure cup; and at least one diaphragm provided along the transmission path of the negative pressure of the negative pressure cup, wherein at least any one of negative pressure stimulation, light stimulation, thermal stimulation, and electrical stimulation is transmitted compositively to the skin or subcutaneous tissues..
Taeyi Lifescience Inc.

Immunostimulatory anti-ceacam1 antibody

An anti-ceacam1 antibody includes at least one antibody heavy chain (vh) domain having antigen binding sites cdr1h, cdr2h and cdr3h, and at least one antibody light chain (vl) domain having antigen binding sites cdr1l, cdr2l and cdr3l. The antigen binding site cdr2h has a sequence homology of at least 80% to the amino acid sequence wintytgept (seq id no.
Universitaet Duisburg-essen

Imidazo[1,2-a]pyridines as stimulators of soluble guanylate cyclase for treating cardiovascular diseases

The present application relates to novel heterocyclyl- and heteroaryl-substituted imidazo[1,2-a]pyridines, to processes for preparation thereof, to the use thereof, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.. .
Bayer Pharma Aktiengesellschaft

Imidazo[1,2-a]pyridines as soluble guanylate cyclase stimulators for the treatment of cardiovascular diseases

The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.. .
Bayer Pharma Aktiengesellschaft

Implantable neural stimulator with mode switching

Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal.
Cardiac Pacemakers, Inc.

Neural stimulator

Methods and apparatus are disclosed relating to the stimulating of tissue including nerve tissue based on combinations of capacitors and resistors. Application and removal of voltage to an electrical circuit is taught as part of a method of creating voltage waveforms for nerve and other tissue with such waveforms creating neural signals..

Wearable soaking physiotherapeutic device with inflatable seal

A physiotherapeutic device comprises a skin soaker for soaking a portion of the user's skin with a liquid when the device is attached to the user. The soaker comprises a tub for receiving the liquid and a resilient seal at a brim of the tub for sealing engagement with the skin to prevent leak of the liquid.

Immunostimulatory compositions and methods of use thereof

Immunostimulatory compositions and methods of use are described to either enhance or diminish the immune stimulation effects of a honey or honey isolate by recognition of the presence of type ii arabinogalactan compounds and utilising this knowledge to tailor the concentration of such compounds thereby adjusting the immune stimulation effects.. .
Comvita New Zealand Ltd.

Acceleration sensors for recording of triggered respiratory signals in neurostimulators

A method of developing a respiration pacing signal includes detecting respiration and movement activity in an implanted patient and developing corresponding respiration and movement signals. A respiration pacing signal is synchronized with the detected respiration activity and delivered to respiration neural tissue of the implanted patient to promote breathing of the implanted patient.
Med-el Elektromedizinische Geraete Gmbh

Controlling ear stimulation in response to electrical contact sensing

Systems and related methods for controlling an ear stimulation device with a personal computing device, in response to determination of electrical contact of an electrode in a stimulator earpiece with an ear of a user of the personal computing device, are described. If the electrode is not in good electrical contact with the ear of the user, delivery of the stimulus is prevented and the user is notified of the status of the electrode.
Elwha Llc

Method and system for generation of customised sensory stimulus

A tinnitus treatment system comprising a sound processing unit, a haptic stimulus unit and an audio delivery unit. The sound processing unit comprises a processor input for receiving an audio signal; and a digital signal processor operable to analyse said audio signal and generate a plurality of actuation signals therefrom which are representative of said audio signal.
Neuromod Devices Limited

Method and identifying the ureter during a minimally-invasive procedure

A method for identifying a ureter during a medical procedure, the method comprising: providing an electrical stimulator comprising: a shaft having at least one electrode; and a power supply connected to the at least one electrode for providing an electrical signal to the at least one electrode; advancing the shaft so that the at least one electrode contacts tissue; operating the power supply so that the electrical signal is applied to the tissue; and visually observing the tissue to determine the presence of a ureter in the tissue.. .
The Methodist Hospital

Combined stimulator and bipolar electrode assembly for mouse electroretinography (erg)

Apparatus for evoking and sensing ophthalmic physiological signals in an eye, the apparatus comprising: an elongated tubular light pipe having a longitudinal axis, a distal end and a proximal end, the distal end terminating in a spheroid recess; an active electrode having a distal end and a proximal end, the active electrode being mounted to the elongated tubular light pipe and extending proximally along the elongated tubular light pipe so that the distal end of the active electrode terminates at the spheroid recess at the distal end of the elongated tubular light pipe; and a reference electrode having a distal end and a proximal end, the reference electrode being mounted to the elongated tubular light pipe and extending proximally along the elongated tubular light pipe so that the distal end of the reference electrode terminates at the spheroid recess at the distal end of the elongated tubular light pipe; wherein the distal end of the active electrode is located closer to the longitudinal axis of the elongated tubular light pipe than the distal end of the reference electrode.. .
Diagnosys Llc

Audio processing pipeline for auditory prosthesis having a common, and two or more stimulator-specific, frequency-analysis stages

An audio processing pipeline, for an auditory prosthesis, includes: a common stage, including a common frequency analysis filter bank, configured to generate a common set of processed signals based on an input audio signal; and first and second stimulator-specific stages, responsive to the common set of signals and including first and second frequency-analysis filter banks, configured to generate first and second sets of processed signals adapted for the first and second hearing stimulators, respectively.. .

Methods, kits and expanding a population of cells

The present invention relates to in vitro-methods of expanding a population of cells such as lymphocytes, comprising contacting a sample comprising a population of cells with a multimerization reagent. The multimerization reagent has reversibly immobilized thereon (bound thereto) a first agent that provides a primary activation signal to the cells and optionally, a second agent that provides a co-stimulatory signal.
Juno Therapeutics Gmbh

Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics

This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against vsig1, ildr1, loc253012, ai216611, c1orf32 or fxyd3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages.
Compugen Ltd.

Immunostimulating agent

Wherein each symbol is as defined herein, have an immunostimulatory effect and are useful as immunostimulating agents, particularly as adjuvants, and for compositions containing such a compound, and for vaccines containing such a compound and an antigen.. .

Spinal cord stimulation with interferential current

A stimulator and a method for the treatment of intractable pain syndromes by electrical stimulation of the spinal cord is disclosed. An example method includes positioning a first pair of implantable electrodes to a dura matter in an epidural space proximate to a subject's spinal cord at predetermined locations, positioning a second pair of implantable electrodes to the dura matter in the epidural space proximate to the subject's spinal cord at predetermined locations, and transmitting signals of first and second frequencies through the first and second pairs of implantable electrodes respectively, so that the signals of the first and second frequencies interfere with each other to produce at least one beat signal proximate to the subject's spinal cord.
Meagan Medical, Inc.

Lipoteichoic acid from lactobacilli as a potent immune stimulatory adjuvant for vaccine development

The present invention provides compositions and methods useful for vaccination and generating cd8+ t lymphocyte immune memory against one or more antigens utilizing lipoteichoic acid.. .
University Of Florida Research Foundation, Incorporated

Method for treating itching

The present invention relates to an anti-itching agent that prevents itch of skin and a method for treating itching. An emulsion, which is produced when sebum and sweat continuously secreted are mixed, contains a stimulatory composition having aqueous and oily properties and can be a causative agent of itch.
Lilac Laboratory Co., Ltd.

Anti-itching agent

The present invention relates to an anti-itching agent that prevents itch of skin. An emulsion, which is produced when sebum and sweat continuously secreted are mixed, contains a stimulatory composition having aqueous and oily properties and can be a causative agent of itch.
Lilac Laboratory Co., Ltd.

Systems and methods for controlling electric field pulse parameters using transcranial magnetic stimulation

A system and methods for controlling pulse parameters during transcranial magnetic stimulation are provided. Multiple coils are placed on external body parts, and are controlled using an external control unit coupled to a stimulator having fast switches.
Yeda Research & Development Co. Ltd. At The Weizmann Institute Of Science

Vaccine composition comprising complexed immunostimulatory nucleic acids and antigens packaged with disulfide-linked polyethyleneglycol/peptide conjugates

The present invention is directed to a composition or vaccine composition comprising a) an adjuvant component comprising or consisting of at least one immunostimulatory nucleic acid sequence, complexed with a complexing agent; b) an antigen, preferably a protein or peptide antigen and/or a nucleic acid sequence encoding said antigen; and c) a carrier molecule for combined packaging the adjuvant component and the antigen. The present invention is also directed to the first medical use of such a composition or vaccine composition and to the second medical use of such a composition or vaccine composition or components thereof for the treatment of diseases, such as infectious or cancer or tumour diseases as defined herein.
Curevac Ag

Generation of hpv-specific t-cells

Embodiments of the disclosure concern methods and compositions for immunotherapy for human papillomavirus infection and diseases associated therewith. In specific embodiments, methods concern production of immune cells that target one or more antigens of hpv16 and/or hpv18, including methods with stimulation steps that employ il-7 and il-15, but not il-6 and/or il-12.
Baylor College Of Medicine

Immunotherapy of cancer using genetically engineered gd2-specific t cells

The present invention concerns immunotherapy for cancers having cells that comprise the ganglioside gd2 antigen. In specific embodiment, t cells having a chimeric receptor that targets gd2 is employed.
Baylor College Of Medicine

Timing channel circuitry for creating pulses in an implantable stimulator device

Timing channel circuitry for controlling stimulation circuitry in an implantable stimulator is disclosed. The timing channel circuitry comprises a addressable memory.
Boston Scientific Neuromodulation Corporation

Neurological stimulator method with detachable lead connection arrangement

A method may include, using an electrode lead(s) having a proximal end and a distal end and comprising spaced apart electrodes carried by the distal end, positioning the electrodes adjacent nerves in a patient; using a subcutaneous lead connector plug comprising a housing electrically connected to the proximal end of the electrode lead(s) and defining a lead connection port(s) and an anchor point(s), positioning the housing along with the proximal end of the electrode lead(s) inside the patient; connecting the anchor point(s) to tissue beneath the patient's skin and, using a first generator lead having a distal end and a proximal end, plugging the distal end of the first generator lead into the lead connector port(s); and connecting the proximal end of the first generator lead to a first neural stimulation generator, and operating the first neural stimulation generator to provide electrical stimulation to the nerves via the electrodes.. .

Systems and methods for enabling appetite modulation and/or improving dietary compliance using an electro-dermal patch

A wearable device for suppressing appetite or hunger in a patient includes a microprocessor, electrical stimulator and at least one electrode configured to deliver electrical stimulation to the epidermis, through a range of 0.1 mm to 10 mm or a range of 0.1 mm to 20 mm of the dermis, of a t2 frontal thoracic dermatome to a t12 frontal thoracic dermatome or meridian of the patient and/or front or back, c5-t1 dermatome across the hand and/or arm, and/or the upper chest regions. The device includes a pad, in which the electrode is disposed, for secure placement of the device on a skin surface of a patient.
Elira Therapeutics Llc

Systems and methods for enabling appetite modulation and/or improving dietary compliance using an electro-dermal patch

A wearable device for suppressing appetite or hunger in a patient includes a microprocessor, electrical stimulator and at least one electrode configured to deliver electrical stimulation to the epidermis, through a range of 0.1 mm to 10 mm or a range of 0.1 mm to 20 mm of the dermis, of a t2 frontal thoracic dermatome to a t12 frontal thoracic dermatome or meridian of the patient and/or front or back, c5-t1 dermatome across the hand and/or arm, and/or the upper chest regions. The device includes a pad, in which the electrode is disposed, for secure placement of the device on a skin surface of a patient.
Elira Therapeutics Llc

Augmentation of cancer and cancer endothelial vaccine immunogenicity by histone deacetylase inhibitors

Disclosed are protocols, procedures and therapeutic compositions useful for augmentation of immunity to cancer and cancer associated endothelial cells by treatment with histone deacetylase (hdac) inhibitors capable of augmenting stimulatory and costimulatory molecules on said cancer vaccines. Additionally, the invention teaches specific concentrations of hdac inhibitors useful for stimulation of in vivo immunity to tumor and tumor endothelial cell targeting vaccines..
Batu Biologics, Inc.

Neural locating method

A method of locating a nerve within an intracorporeal space includes advancing a distal end portion of a stimulator toward an anatomical target within the intracorporeal space, and periodically applying a first electrical stimulus from a first electrode disposed on a central axis of the stimulator. If a muscular response to the first electrical stimulus is detected, a locating electrical stimulus is then applied from a plurality of locations offset from the central axis of the stimulator, and a magnitude of the response of the muscle is monitored.
Innovative Surgical Solutions, Llc

Systems and methods for monitoring neurostimulation dosing

Various implantable device embodiments may comprise a neural stimulator configured to deliver a neurostimulation therapy with stimulation on times and stimulation off times where a dose of the neurostimulation therapy is provided by a number of neurostimulation pulses over a period of time. The neural stimulator may be configured to monitor the dose of the delivered neurostimulation therapy against dosing parameters.
Cardiac Pacemakers, Inc.

Spinal cord stimulator system

Spinal cord stimulation (scs) system having a recharging system with self-alignment, a system for mapping current fields using a completely wireless system, multiple independent electrode stimulation outsource, and ipg control through software on smartphone/mobile device and tablet hardware during trial and permanent implants. Scs system can include multiple electrodes, multiple, independently programmable, stimulation channels within an implantable pulse generator (ipg) providing concurrent, but unique stimulation fields.
Globus Medical, Inc.

Devices and methods for controlling tremor

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, parkinson tremor, and other forms of tremor. The peripheral nerve stimulator can be either a noninvasive surface stimulator or an implanted stimulator.

Apparatus for treating pelvic floor disorders and related methods of use

A method of optimizing the electrical stimulation of a bladder of a patient including selecting a first subset of electrodes from a set of electrodes positioned adjacent to a set of nerves associated with the bladder. The set of electrodes may include one or more electrodes, each of which may be configured to deliver electrical stimulation pulses generated by a stimulator device to the nerves.
Boston Scientific Scimed, Inc.

Methods of treating cancer using rad51 small molecule stimulators

Methods of killing or inhibiting the growth cancer cells and tumors and of treating cancer by administering compounds that stimulate the activity of rad51. Cells overexpressing rad51 or with other imbalances in homologous recombination machinery are particularly susceptible targets of rad51 stimulators..
The University Of Chicago

Vibratory saliva stimulator

A device for stimulating saliva production in a subject includes a source of vibratory motion and a saliva stimulation assembly configured to elicit a salivary response by delivery of a vibratory stimulus. The saliva stimulation assembly includes one or more contact points coupled to the source of vibratory motion and configured to be placed against one or more stimulation sites on one or more portions of skin of the subject.
L'oreal



Stimulator topics:
  • Stimulator
  • Genetically
  • Immune System
  • Immune Response
  • Immunostimulator
  • Nanotechnology
  • Prophylaxis
  • Immunomodulator
  • Hemodynamic
  • Electrical Pulse
  • Dysfunction
  • Vagus Nerve
  • Frequency Band
  • Ion Channel
  • Cochlear Implant


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    This listing is a sample listing of patent applications related to Stimulator for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Stimulator with additional patents listed. Browse our RSS directory or Search for other possible listings.


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