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Steoporosis

Steoporosis-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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New molecules for bone tissue regeneration
Universita' Di Pisa
November 09, 2017 - N°20170319605

The invention relates to compounds of general formula (i) and pharmaceutically acceptable salts thereof: (i) wherein ri is selected from an scn— group or is an rconh— group; in particular, where ri=rconh, r is selected from an aromatic benzene ring substituted with an scn— group in the ortho, meta or para position, according to the following ...
Combination of lupeol acetate and curcumin used for the treatment or prevention of osteoporosis
Universita' Di Pisa
November 02, 2017 - N°20170312294

The present invention relates to synergistic combinations of lupeol acetate and curcumin at low dosage, and their use for the treatment or prevention of osteoporosis.
Methods for treatment of disease using galvanic vestibular stimulation
The Regents Of The University Of California
October 26, 2017 - N°20170304616

Methods are provided for treating diseases by altering body mass composition in a human subject through application of galvanic vestibular stimulation (gvs) using electrodes placed in electrical contact with the subject's scalp at a location corresponding to each of the subject's left and right vestibular systems. The methods may be used to treat obesity-related diseases such as diabetes, hypertension, type 2 ...
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Compounds and methods for kinase modulation, and indications therefor
Endorecherche, Inc.
October 05, 2017 - N°20170283423

In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on one or more of fms, kit, flt3, trka, trkb and trkc kinase protein. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of one or more of fms, ...
Proxisome proliferator activated receptor (ppar) compounds and methods of using the same
The University Of Toledo
October 05, 2017 - N°20170283385

Peroxisome proliferator activated receptor (ppar) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
Therapeutic compositions and methods
Pop Test Oncology Llc
October 05, 2017 - N°20170281652

This invention relates the use of cortisol blockers (glucocorticoid receptor [gr] antagonists) for the prevention or addiction induced anxiety and withdrawal side effects as a therapeutic and in concert with a diagnostic. Such addictions could be, but are not limited to, alcohol, drugs, caffeine, sugar, food, nicotine, etc. The present invention further relates to the use of cortisol blockers (gr ...
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Gamma-diketones as wnt/beta -catenin signaling pathway activators
Samumed, Llc
September 14, 2017 - N°20170260176

The present disclosure provides γ-diketones or analogs thereof, that activate wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to ...
Composition for preventing, improving or treating postmenopausal osteoporosis comprising scopolin
Ajou University Industry-academic Cooperation Foundation
September 07, 2017 - N°20170252363

Provided is a pharmaceutical composition for preventing, improving, or treating postmenopausal osteoporosis in women, the composition including, as an active ingredient, scopolin, a derivative thereof, or a pharmaceutically acceptable salt thereof, wherein scopolin has good efficacy in stimulating osteoblast differentiation, and is also effective in inhibiting a reduction in bone density after menopause, low density in a bone microstructure, a ...
B- and y -diketones and y -hydroxyketones as wnt/ b -catenin signaling pathway activators
Ajou University Industry-academic Cooperation Foundation
August 31, 2017 - N°20170246154

Which activates wnt/β-catenin signaling and thus treats or prevents diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising parkinson's disease, strokes, ischemic cerebral disease, epilepsy, ...
Phosphonate compounds
The Regents Of The University Of California
August 24, 2017 - N°20170239279

The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e. G., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
Composition and method of using mir-302 precursors as drugs for treating alzheimer's diseases
Mello Biotechnology, Inc.
August 03, 2017 - N°20170218362

This invention generally relates to a composition and method of using recombinant micrornas (mirna) and their hairpin-like precursors (pre-mirna) as therapeutic drugs for treating alzheimer's diseases (ad). More specifically, the present invention relates to the use of man-made mirna mir-302 precursors (pre-mir-302) for ad therapy in humans. These pre-mir-302 molecules can be mass produced in prokaryotes as a form of ...
N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and n-(4- hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamides and ...
Pimco 2664 Limited
August 03, 2017 - N°20170217881

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted n-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as hmc compounds) that are useful, for example, in the treatment of disorders (e. G., diseases) including, inflammation and/or joint destruction ...
Pharmaceutical formulations comprising chondroitin sulfate and hyaluronic acid derivatives
Fidia Farmaceutici S.p.a.
August 03, 2017 - N°20170216344

The present invention relates to pharmaceutical formulations containing a combination of specific high-molecular weight hyaluronic acid derivatives and chondroitin sulfate to be used in the treatment of osteoarthritis, of subchondral damage, osteoporosis, synovitis, tenosynovitis, tendinitis, tendinosis, as an intra-articular washing liquid and as a viscous substitute of synovial fluid following osteochondral surgery. These formulations are also suitable for the treatment ...
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  • + full patent PDF documents of Steoporosis-related inventions.
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Treating androgen deprivation therapy induced hot flashes and bone loss in men using cis-clomiphene
Aspen Park Pharmaceuticals , Inc.
July 20, 2017 - N°20170202788

This invention provides: 1) a method of treating androgen-deprivation induced osteoporosis, bone fractures, loss of bone mineral density (bmd), and/or hot flashes in a male subject suffering from prostate cancer; 2) a method of preventing androgen-deprivation induced osteoporosis, bone fractures, loss of bone mineral density (bmd), and/or hot flashes in a male subject suffering from prostate cancer; 3) a method of ...
Polypeptides derived from calcitonin receptors and methods of use
The Research Foundation For The State University New York
July 06, 2017 - N°20170190760

The present invention is based, in part, on our discovery of compositions and methods that can be used to treat a patient who has a compromised bone (due, for example, to a disease such as osteoporosis or an injury such as a bone fracture). The compositions can also be administered prophylactically. For example, they can be administered to help maintain ...
Salt forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4...
Pfizer Inc.
July 06, 2017 - N°20170190663

Novel salt forms of [r—(r*,r*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid characterized by their x-ray powder diffraction pattern and solid-state nmr spectra are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for ...
Solid oral formulation of fenretinide
Laurent Pharmaceuticals
July 06, 2017 - N°20170189356

Amorphous solid dispersions suitable for oral delivery comprising fenretinide or an analog thereof and at least one matrix polymer, and processes for making the dispersions, are disclosed. Also disclosed are solid oral formulations comprising the amorphous solid dispersions, as well as uses thereof for the prevention and/or treatment of diseases or conditions treatable by fenretinide, including but not limited ...
Novel peptides for preventing or treating bone diseases and use thereof
Kyungpook National University Industry - Academic Cooperation Foundation
June 29, 2017 - N°20170183381

The present disclosure relates to a novel peptide for preventing or treating bone diseases. Further, the present disclosure relates to a polynucleotide encoding the peptide, a vector including the polynucleotide, a host cell transformed by the vector, and a method for producing the peptide by using the host cell. Furthermore, the present disclosure relates to a composition for preventing or ...
Llp2a-bisphosphonate conjugates for osteoporosis treatment
The Regents Of The University Of California
June 22, 2017 - N°20170174722

The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e. G. Llp2a, conjugated with a bisphosphonate drug, e. G. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the α4β1 integrin on mesenchymal ...
Protease inhibitors
The Regents Of The University Of California
June 15, 2017 - N°20170166538

Or a pharmaceutically acceptable salt, n-oxide or hydrate thereof, have utility in the treatment of disorders characterized by inappropriate expression or activation of cathepsin k, such as osteoporosis, osteoarthritis, rheumatoid arthritis or bone metastases:
Novel therapeutic uses of benzylideneguanidine derivatives for the treatment of proteopathies
Inflectis Bioscience
June 01, 2017 - N°20170151196

The present invention relates to novel uses of a compound of formula (i), or a tautomer and/or a pharmaceutically acceptable salt thereof, in treating a disorder associated with the ppp1r15a pathway and associated with protein misfolding stress and in particular with accumulation of misfolded proteins selected in the group of tauopathies, synucleinopathies, polyglutamine and polyalanine diseases, leukodystrophies, ...
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