This page is updated frequently with new Stem Cells-related patent applications.
|Recombinant adeno-associated vectors for targeted treatment|
Novel adeno-associated virus (aav) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues.
City Of Hope
|Neo-islets comprising stem and islet cells and treatment of diabetes mellitus therewith|
Described are neo-islets comprising: a) dedifferentiated islet cells and mesenchymal and/or adipose stem cells; or b) redifferentiated islet cells and mesenchymal and/or adipose stem cells where the cells have been treated so as to facilitate redifferentiation. Further described herein are methods of generating neo-islets, the methods comprising: culturing a) dedifferentiated islet cells and mesenchymal and/or adipose stem cells; or b) redifferentiated islet cells and mesenchymal and/or adipose stem cells; on a surface that promotes the formation of cell clusters.
|Compositions of adult disc stem cells and methods for the treatment of degenerative disc disease|
This invention provides an isolated disc stem cell population, compositions, and methods of obtaining and growing the same. Moreover, this invention provides an isolated discosphere, compositions, and methods of obtaining and growing the same.
|Methods of selective cell attachment/detachment, cell patternization and cell harvesting by means of near infrared rays|
The present invention relates to a method for selective cell attachment/detachment, cell patternization and cell harvesting by means of near infrared rays. More particularly, conducting polymers or metal oxides having exothermic characteristics upon irradiation of near infrared light is used as a cell culture scaffold, thus selectively attaching/detaching cells without an enzyme treatment.
Industry-academic Cooperation Foundation, Yonsei University
|Bone grafts including osteogenic stem cells, and methods relating to the same|
Bone grafts and constructs including stem cells are provided. Example bone grafts include osteogenic stem cells seeded on a scaffold of osteoconductive cortico-cancellous chips and/or osteoinductive demineralized bone.
Globus Medical, Inc.
|Activator for mesenchymal stem cells, activated mesenchymal stem cells, and producing same|
[solution] an activator for mesenchymal stem cells, mesenchymal stem cells activated by the activator, a method for producing the same, and a pharmaceutical containing the activated mesenchymal stem cells are provided.. .
|Bioengineered allogeneic valve|
The present disclosure relates to methods for recellularization of valves in valve-bearing veins. This method is useful for producing an allogeneic venous valve, wherein a donor valve-bearing vein is decellularized and then recelluiarized using whole blood or bone marrow stem cells.
|Method of hypothermic storage and shipping of stem cells and differentiated organ stem cells|
The present disclosure provides for the use of a temperature controlled shipping container as a method for the packaging and distribution of mammalian cells, e.g., in induced pluripotent stems cells (ipsc), and various organ cells differentiated from the ipsc. In one embodiment, a shipping box that utilizes a vacuum, desiccant and insulation construct is employed to package ipsc and their derivatives or progeny that are or have been deposited onto microwell plates or tubes that contain a nutrient solution during storage and shipping.
|Methods of differentiating stem cells by modulating mir-124|
Provided herein are methods of differentiating stem cells via modulating mir-124, and the differentiated cells thereby. Also provided herein are methods for the treatment of diseases using the differentiated cells..
Accelerated Biosciences Corp.
|Cd82-positive cardiac progenitor cells|
An object of the present invention is to provide a myocardial progenitor cell that is specifically induced to differentiate into a cardiomyocyte, and a method for preparing the myocardial progenitor cell. A method for preparing a cd82-positive cell includes, in sequence, a step (a) of obtaining stem cells, a step (b) of subjecting the stem cells to induction treatment of differentiation into cardiovascular cells, and a step (c) of separating, from the stem cells having been subjected to the induction treatment of differentiation in the step (b), a cd82-positive cell being negative for at least one cell surface marker selected from cd73, cd44, cd105, cd121a, cd18, and cd120a.
Iheart Japan Corporation
Macs-based purification of stem cell-derived retinal pigment epithelium
Provided herein are methods of enriching a retinal pigment epithelium (rpe) cell population derived from stem cells. Such a method may comprise removing contaminating cells through the depletion of cd24 positive cells, cd56 positive cells, and/or cd90 positive cells from a starting population of rpe cells..
Cellular Dynamics International, Inc.
Selective immunodepletion of endogenous stem cell niche for engraftment
The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of gvhd or graft rejection. Aspects of the present invention are based on the discovery that the depletion of the endogenous stem cell niche facilitates efficient engraftment of stem cells into that niche.
The Board Of Trustees Of The Leland Stanford Junior University
Method of stem cell delivery into the brain during chronic disease using blood brain barrier permeabilizers
Blood brain barrier (bbb) permeabilizers, such as mannitol, can facilitate the entry of stem cells from the periphery to the stroke brain. It is unknown whether bbb permeation in the chronic stage of the disease still facilitates the entry of stem cells from the periphery to the injured brain.
University Of South Florida
Synthetic cornea from retinal stem cells
Methods of producing synthetic corneas are disclosed which are differentiated from retinal stem cells (rsc) derived from parthenogenetically activated human oocytes, including that such synthetic corneas are produced in the absence of a 3-d scaffold. Isolated synthetic corneas, produced by the disclosed methods, are also described..
International Stem Cell Corporation
In vivo and ex vivo expansion of hematopoietic stem cells with a targeted combination of clinically tested, fda approved drugs
The present invention provides a therapeutic approach to maintain and expand hscs in vivo using currently available medications that target gsk-3 and mtor. The present invention also provides a system and method for the ex vivo culturing of hscs, where an mtor inhibitor is combined with a gsk-3 inhibitor within the culturing conditions..
The Trustees Of The University Of Pennsylvania
Mesenchymal stem cells with enhanced immunosuppressive capability
Compositions of hla-g+ msc and methods of using them, including methods of transplanting compositions of hla-g+ msc into human recipients, are provided. Also provided are methods of preparing compositions of hla-g+ msc, including by treatment with dna methylation inhibitors..
Escape Therapeutics, Inc.
Cardiomyocytes from induced pluripotent stem cells from patients and methods of use thereof
Human somatic cells obtained from individuals with a genetic heart condition are reprogrammed to become induced pluripotent stem cells (ips cells), and differentiated into cardiomyocytes for use in analysis, screening programs, and the like.. .
The Board Of Trustees Of The Leland Stanford Junior University
Megakaryocytic particles and microparticles for cell therapy & fate modification of stem and progenitor cells
Applications in transfusion medicine requiring platelets, and hematopoietic stem-cell transplantations require either platelets or enhancement of in vivo platelet biogenesis. Gene therapy applications of hematopoietic stem and progenitor cells (hspcs) require effective and specific modification of hspcs by dna, rna or other biological molecules.
Methods and compositions for treatment of bone defects with placental cell populations
Provided herein are methods of using adherent placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. Also provided herein are methods of differentiating the placental stem cells.
Pharmaceutical composition for use in the treatment and/or the prevention of osteoarticular diseases
An intra-articular pharmaceutical composition is used for the treatment and/or the prevention of acute or chronic osteoarticular diseases and acute or chronic osteoarticular symptoms especially osteoarthritis. The composition includes a possibly adequate pharmaceutical carrier or diluent, a glycosaminoglycan, a compound activating the alpha 2 adrenergic receptor, an anti-inflammatory agent and stem cells..
Method of dietary treatment for genetic and epigenetic diseases and disorders
Genetic and epigenetic diseases and disorders are treated with fda approved dietary compositions in the form of dietary supplements and nutraceuticals. The diseases and disorders to be treated include rett syndrome, trinucleotide repeat diseases such as fragile x syndrome, memory impairment, chronic inflammation, pre-cancerous conditions which involve cancer stem cells, and post-cancerous conditions which involve cancer stem cells which have survived in spite of cancer treatment.
Immune hepatotoxicity screening method using hepatocytes derived from human stem cells
The present invention relates to an immune hepatotoxicity screening method using hepatocytes derived from human stem cells. After hepatocytes differentiated from human stem cells and human hepatocytes are treated with ethanol, ccl4, and acetaminophen to induce immune hepatotoxicity, a hepatocellular immunotoxic material assay system is constructed in order to verify cytokines, chemokines, and lipid mediators, which are mediators secreted from the hepatocytes, and an immunotoxic material can be confirmed in the cells having the induced hepatotoxicity by using the system.
Korea Advanced Institute Of Science And Technology
Method for assessing state of differentiation of cells
In the present invention, for test cells which are either stem cells whose state of differentiation is unknown or cells obtained from stem cells by differentiation induction, an lc-ms or gc-ms analysis is performed on culture supernatants collected from a culture dish of the test cells and a culture dish of control cells whose state of differentiation is known, and the state of differentiation of the test cells is assessed based on the amount, determined as a result of the aforementioned analysis, of at least one compound selected from the group of putrescine, kynurenine, cystathionine, ascorbic acid, riboflavin, pyruvic acid, serine, cysteine, threonic acid, citric acid, and orotic acid in both the culture supernatant of the test cells and the culture supernatant of the control cells.. .
Novel labelling cancerization-causing cell in stem cells, and therapy method
The invention provides a method to search for a best promoter for reliably targeting a cancerization-causing cell in human es/ips cells. Discovering a gene which can kill or remove a cancerization-causing cell contained in human es/ips cells with high efficiency is also provided.
Compositions comprising a mitofusin inhibitor for promoting cell reprogramming and a use thereof
The present invention relates to a composition comprising a repressor of mitofusin gene expression, an inhibitor of mitofusin protein activity, or a mixture thereof as an active ingredient for promoting reprogramming a differentiated cell into a pluripotent stem cell, and a use thereof. The composition according to the present invention increases the efficiency of reprogramming as well as reduces the time required for reprogramming to produce pluripotent stem cells.
Korea Research Institute Of Bioscience And Biotechnology
Cell carrier, associated methods for making cell carrier and culturing cells using the same
A carrier for expansion of pluripotent stem cells is provided, wherein the carrier comprises a substrate comprising one or more outer surfaces, wherein the one or more outer surfaces are modified with gas plasma treatment, and one or more structured indentations on one or more of the outer surfaces. The carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.05 mm to 1.2 mm and each of the structured indentations has a major axis in a range from about 0.1 mm to 0.5 mm, a minor axis in a range from about 0.1 mm to 0.5 mm and a depth in a range from about 0.025 mm to about 0.5 mm.
General Electric Company
Fiber reinforced hydrogels and methods of making same
Disclosed herein are biomaterials that include a plurality of fibers embedded in a matrix of hydrogel material. The plurality of fibers and hydrogel material are formed during one process step.
Case Western Reserve University
Bioengineered allogeneic blood vessel
The present invention relates to methods for recellurization of blood vessels. This method is particularly useful for producing an allogeneic vein, wherein a donor vein is decellularized and then recellularized using whole blood or bone marrow stem cells.
Methods of enhancing stem cell engraftment
An effective amount of a composition comprising a stem cell, a stem cell engraftment enhancer, and a carrier fluid, for use in the treatment of an individual having a disease or at risk of developing a disease, wherein the disease is a vascular-associated disease and/or a muscular disease. A composition comprising pgi2-overexpressing human mesenchymal stem cells (pgi2-hmscs), and a carrier fluid; wherein an effective amount of the composition is administered via a single treatment stream as an intramuscular injection to an individual having a disease or at risk of developing a disease, wherein the disease is a vascular-associated disease and/or a muscular disease, and wherein stem cell engraftment is enhanced in said individual by greater than about 200%, when compared to stem cell engraftment in an individual treated with a composition lacking the stem cell engraftment enhancer..
Texas Heart Institute
Encapsulated mesenchymal stem cells and uses thereof
Provided is a composition-of-matter comprising a microcapsule encapsulating mesenchymal stem cells, wherein at least 97% of cells in said microcapsule are said mesenchymal stem cells. Also provided are methods of generating and using the composition-of-matter..
Technion Research & Development Foundation Limited
Compositions, methods and uses for the treatment of diabetic neuropathies
The present invention relates to compositions and methods for the treatment of diabetic neuropathies. More particularly, this invention relates to compositions and methods for promoting nerve regeneration in a subject suffering from, or at risk of suffering from a diabetic neuropathy, and for protecting nervous system cells against the stresses resulting from the perturbation of glucose homeostasis.
Methods to mobilize progenitor/stem cells
“linker” represents a bond, alkylene (1-6c) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.. .
Methods and compositions for targeting cancer stem cells
Aspects of the disclosure relate to methods that involve activating the protein kinase a (pka) pathway to induce cancer stem cells (cscs) to undergo a mesenchymal to epithelial transition. Methods provided herein are useful, in some embodiments, because they render cscs amenable to treatment with conventional cancer therapies.
Whitehead Institute For Biomedical Research
Metformin in treatment of neuroblastoma
Use of metformin in inhibition of growth and/or viability of human neuroblastoma cells is described. Use of metformin in inhibition of growth and/or viability of neuroblastoma cancer stem cells is also described.
University Of South Carolina
Aspirating implants and bony regeneration
Devices and methods for in situ drawing, filtering and seeding cells from the marrow of surrounding bone into a fusion cage without any of the challenges mentioned above. Various implants and devices with aspiration ports that enable in-situ harvesting and mixing of stem cells.
Depuy Synthes Products, Inc.
Engineered cellular pathways for programmed autoregulation of differentiation
The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type.
The Trustees Of Princeton University
Application of induced pluripotent stem cells to generate adoptive cell therapy products
The application of induced pluripotent stem cells (ipscs) to generate adoptive cell therapy products and usage of ipscs for screening potential toxicity of immune receptors are described herein. In some aspects, ipscs and cells differentiated therefrom are provide which do not express a hla gene (e.g., hla-a)..
Board Of Regents, The University Of Texas System
Differentiation of human embryonic stem cells into pancreatic endocrine cells
The present invention provides methods to promote differentiation of pancreatic endoderm cells to pancreatic endocrine rich clusters and to enhance insulin expression in hormone-expressing cells.. .
Janssen Biotech, Inc.
Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
The present disclosure relates to compositions and methods comprising cell surface markers for hes-derived cells, in particular, endoderm lineage cells including pancreatic endoderm-type cells, derived from hes cells.. .
Selection and use of stem cells
A population of human stem cells is, or is selected to be, positive for cd271 and acetylated tubulin. Cells are isolated by a method comprising isolation of a cell from a mixed population of cells based on expression of cell surface markers, wherein the markers are cd271 and acetylated tubulin.
National University Of Ireland, Galway
Method of producing skin-derived precursor cells
A method of producing skin-derived precursor cells, comprising culturing human-derived pluripotent stem cells in a differentiation-inducing medium containing an agonist of wnt signaling to differentiate the pluripotent stem cells into skin-derived precursor cells; a differentiation-inducing medium for differentiating human-derived pluripotent stem cells into skin-derived precursor cells, comprising an agonist of wnt signaling as a differentiation-inducing promoter; and a differentiation-inducing promoter for differentiating human-derived pluripotent stem cells into skin-derived precursor cells, comprising an agonist of wnt signaling as an active ingredient.. .
Method for inducing endodermal and mesodermal differentiation from human pluripotent stem cells by cxcr2 suppression
The present invention relates to a method of inducing the differentiation of human pluripotent stem cells into endoderm and mesoderm by cxcr2 inhibition, and more particularly, to a method of promoting the differentiation of human pluripotent stem cells into endoderm and mesoderm by inhibiting the expression of the surface receptor cxcr2 in the stem cells by use of an shrna technique. The method of inducing the differentiation of human pluripotent stem cells into endoderm or mesoderm by cxcr2 inhibition according to the present invention can increase the efficiency and utility of stem cells as a cell therapeutic agent, because it promotes the differentiation of stem cells into a specific germ layer serving as the origin of target cells, which is the first important step for inducing the differentiation of stem cells into specific cells..
Korea University Research And Business Foundation
Method for inducing ectodermal differentiation of embryoid bodies derived from human pluripotent stem cells by cxcr2 stimulation
The present invention relates to a method of inducing the differentiation of human pluripotent stem cell-derived embryoid bodies into ectoderm by cxcr2 stimulation, and more particularly, to a method of promoting the differentiation of human pluripotent stem cell-derived embryoid bodies into ectoderm by stimulating and activating the surface receptor cxcr2 of the embryoid bodies with the cxcr2-specific ligand gro-α. The method of inducing the differentiation of human pluripotent stem cell-derived embryoid bodies into ectoderm by cxcr2 stimulation according to the present invention can increase the efficiency and utility of stem cells as a cell therapeutic agent, because it promotes the differentiation of stem cells into a specific germ layer serving as the origin of target cells, which is the first important step for inducing the differentiation of stem cells into specific cells..
Korea University Research And Business Foundation
Native wharton's jelly stem cells and their purification
Noncultured wharton's jelly stem cells and methods of their purification, storage and use are provided.. .
Auxocell Laboratories, Inc.
A serum-free medium for the growth of mesenchymal stem cells comprises fgf, tgf-β and lipoprotein.. .
National University Of Ireland, Galway
Stem cells having thin multilayer structure
Disclosed are stem cells having a thin multilayer structure, a method of preparing the same, and use thereof for cytotherapy. In accordance with the present invention, stem cells with a thin multilayer structure having improved stability and controlled multifunctionality are provided.
Chung-ang University Industry-academic Cooperation Foundation
Compositions and methods for modulating stem cells and uses thereof
There are provided compositions and methods for modulating stem cell division decisions, in particular, division symmetry. It has been demonstrated that wnt7a acts through frizzled-7 receptor expressed on the surface of adult stem cells, e.g.
Ottawa Hospital Research Institute
Anticancer peptide for inhibiting proliferation of cancer stem cells and use thereof
The present invention relates to an anticancer composition comprising a peptide that inhibits the proliferation of cancer stem cells present in tumor tissue and that induces apoptosis of such cancer stem cells, and more particularly, to an anticancer peptide that inhibits the activity of nf-κb which is overexpressed specifically in cancer stem cells present in tumors.. .
Nano Intelligent Biomedical Engineering Corporation Co., Ltd.
Treatment of conditions and complications in infants
Provided herein are compositions and methods for treating one or more disorders or conditions in infants, including premature infants, by administering to such infants umbilical cord blood or cells obtained from umbilical cord blood and, optionally, cells obtained from placental perfusate, placental stem cells and/or blood additives. Also provided herein are methods for treating one or more disorders or conditions in infants, including premature infants, by administering to such infants cells obtained from placental perfusate alone or placental stem cells alone or in combination with umbilical cord blood or cells obtained from umbilical cord blood..
Use of casein kinase i inhibitors for depleting stem cells
A method of treating cancer in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of a casein kinase i alpha (ckialpha) inhibitor, wherein the cancer is not associated with an adenomatous polyposis coli (apc) mutation.
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.
Method for preparing induced pluripotent stem cell, composition used in method, and uses thereof
Provided are a method for preparing an induced pluripotent stem cell and a composition used in the method. The method comprises: introducing a composition for promoting the formation of an induced pluripotent stem cell into a somatic cell, the composition comprising: (i) a c-jun antagonist and one group of factors from among the following seven such groups: (1) sox2, klf4 and c-myc, (2) klf4 and c-myc, (3) oct3/4, klf4 and c-myc, (4) sox2, nanog and lin28, (5) oct3/4, nanog and lin28, (6) oct3/4, klf and sox2, and (7) klf4 and sox2; or (ii) the c-jun antagonist, jhdm1b and id1, and at least one of glis1, sall4 or lrh1; or (iii) the c-jun antagonist, jhdm1b and id1, and at least one of: oct4, klf4, sox2, lin28, esrrb, lef1, utf1 or mirna c.
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Methods for epicardial differentiation of human pluripotent stem cells
Methods for generating high-yield, high-purity epicardial cells are described. Wnt/β-catenin signaling is first activated in human cardiac progenitor cells, by, for example, inhibiting gsk-3 to induce differentiation into epicardial cells.
Wisconsin Alumni Research Foundation
Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons
The present invention relates to a method for producing mammalian neural plate border stem cells (npbscs), comprising: (a) differentiation of mammalian pluripotent stem cells by (a-i) culturing mammalian pluripotent stem cells in pluripotent stem cell medium for about 24 to about 96 hours, wherein the pluripotent stem cell medium comprises: (i) an inhibitor of the activin/tgf-β signalling pathway; (ii) an inhibitor of the bmp signalling pathway; (iii) an activator of the canonical wnt signalling pathway; and (iv) an activator of the hedgehog signalling pathway; subsequently (a-ii) culturing the cells obtained in step (a-i) for about 24 to about 96 hours in a neural medium, wherein the neural medium comprises: (i) an inhibitor of the activin/tgf-β signalling pathway; (ii) an inhibitor of the bmp signalling pathway; (iii) an activator of the canonical wnt signalling pathway; and (iv) an activator of the hedgehog signalling pathway; subsequently (a-iii) culturing the cells obtained in step (a-ii) for about 24 to about 96 hours in a neural medium, wherein the neural medium comprises: (i) an activator of the canonical wnt signalling pathway; (ii) an activator of the hedgehog signalling pathway; and (iii) an inhibitor of oxidation; and (b) plating the obtained differentiated mammalian pluripotent stem cells in npbscs expansion medium, wherein the npbscs expansion medium comprises (i) an activator of the canonical wnt signalling pathway; (ii) an activator of the hedgehog signalling pathway; and (iii) an inhibitor of oxidation; and expanding the cells in the npbscs expansion medium for about 24 to about 96 hours; (c) splitting the cells obtained in (b) and further expanding the cells in the npbscs expansion medium; and (d) repeating step (c) at least two times. The present invention further relates to neural plate border stem cells obtainable by the method of the invention and the use of the cells of the invention in medicine..
Max-planck-gesellschaft Zur Förderung Der Wissenschaften E.v.
Automated cell culturing and harvesting device
An automated cell culturing device, which expands, detaches and prepares cells, ready to be implanted in vivo is disclosed. The device is composed by a multi-layered cell culture chamber, a cell preparation chamber, and critical parameters control units which automatically drive the cell culture medium circulation, change and refill.
Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells
Compounds of general formula or salts or prodrugs thereof, are provided and described herein. The compounds are useful to expand hematopoietic stem cell and/or hematopoietic progenitor cell populations.
UniversitÉ De MontrÉal