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Stem Cells

Stem Cells-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods of selecting and isolating cancer stem cells
The Regents Of The University Of California
January 11, 2018 - N°20180011100

Provided herein are methods for selecting/identifying and/or isolating cancer stem cells from a biological sample or a cell culture sample using a fluorescent glucose analog. Also provided herein are methods for selecting/identifying and/or isolating leukemia stem cells and subpopulations thereof. The present invention is based, in part, on the discovery that cancer stem cells can be ...
Method of producing exosomes from stem cells and use thereof
National Health Research Institutes
January 11, 2018 - N°20180010133

A method of producing induced exosomes, the method comprising: contacting an isolated population of stem cells with an amount of a prostaglandin e receptor 4 (ep4) antagonist effective for inducing release of exosomes, whereby induced exosomes are released from the stem cells, and isolating the induced exosomes.
Induction of hemogenic endothelium from pluripotent stem cells by forced expression of transcription factors
Wisconsin Alumni Research Foundation
January 11, 2018 - N°20180010124

Described herein are methods and related compositions for inducing differentiation of human pluripotent stem cells (hpscs) into hemogenic endothelium with pan-myeloid potential or restricted potential, by forced expression in the hpscs of a combination of transcription factors as described herein.
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Differentiation of macrophages from pluripotent stem cells
Agency For Science, Technology And Research
January 11, 2018 - N°20180010096

The present invention relates to a method of culturing primitive-like macrophages from stem cells, a kit when used in the method thereof and uses of the primitive like macrophage for in-vitro disease models and for screening compounds for therapy. One embodied culture method comprises contacting and incubating embryonic stem cells or induced pluripotent stem cells with a serum-free culture media ...
A direct conversion method of human fibroblasts into neural stem cells using small molecules
Korea University Research And Business Foundation
January 11, 2018 - N°20180010094

The present invention relates to a method of converting human fibroblasts into neural stem cells, and more particularly, to a method of directly converting human fibroblasts into neural stem cells using only a combination of small-molecule compounds without any introduction of a foreign gene, and to the use of the neural stem cells. The method of directly converting human fibroblasts ...
Method for inducing differentiation of corneal epithelial cells from pluripotent stem cells
Osaka University
January 11, 2018 - N°20180010093

The present invention relates to a method for inducing the differentiation of corneal epithelial cells from pluripotent stem cells. More specifically, the present invention relates to a method for autonomously differentiating pluripotent stem cells, such as human ips cells, into ectodermal cell lineage in a serum-free medium without using feeder cells and inducing the differentiation of the resultant ocular surface ...
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Heterocyclic compounds and use thereof
National Health Research Institutes
January 11, 2018 - N°20180009786

Heterocyclic compounds of formula (i) shown herein. Also disclosed are pharmaceutical compositions containing the heterocyclic compounds and methods of using the heterocyclic compounds to mobilize hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation. Further provided are methods for treating tissue injury, cancer, inflammatory disease, and autoimmune disease with the heterocyclic compounds.
Bone tissue engineering by ex vivo stem cells ongrowth into three-dimensional trabecular metal
Zimmer Trabecular Metal Technology, Inc.
January 11, 2018 - N°20180008747

Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant ...
Surgical sutures incorporated with stem cells or other bioactive materials
Bioactive Surgical, Inc.
January 11, 2018 - N°20180008744

Materials and methods for immobilizing bioactive molecules, stem and other precursor cells, and other agents of therapeutic value in surgical sutures and other tissue scaffold devices are described herein. Broadly drawn to the integration and incorporation of bioactive materials into suture constructs, tissue scaffolds and medical devices, the present invention has particular utility in the development of novel systems that ...
Chimeric antigen receptor targeting of tumor endothelium
Batu Biologics, Inc.
January 11, 2018 - N°20180008670

Disclosed are methods, protocols, and compositions of matter related to utilization of chimeric antigen receptor (car) expressing cells for the targeting of tumor endothelium utilizing chimeric antigen receptor expressing stem cells. In one embodiment tumor endothelium specific antigens are utilized as targets of the antigen binding domain of a car, which is attached to an extracellular hinge domain, a domain ...
Scaffold-seeded oral mucosa stem cells
Technion Research & Development Foundation Limited
January 11, 2018 - N°20180008648

A method of treating a spinal cord injury in a subject in need thereof is disclosed. The method comprises implanting a scaffold into the spinal cord of a subject, wherein the scaffold is seeded with oral mucosa stem cells (omsc) and/or cells that have been ex vivo differentiated from said omscs, thereby treating the spinal cord injury.
Vivo iron labeling of stem cells and tracking these labeled stem cells after their transplantation
The Board Of Trustees Of The Leland Stanford Junior University
January 11, 2018 - N°20180008643

Intravenous ferumoxytol is used to effectively label mesenchymal stem cells (mscs) in vivo and is used for in vivo tracking of stem cell transplants with magnetic resonance (mr) imaging. The method eliminates risk of contamination and biologic alteration of mscs associated with ex-vivo-labeling procedures.
Methods for production of platelets from pluripotent stem cells and compositions thereof
Astellas Institute For Regenerative Medicine
January 11, 2018 - N°20180008640

Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hescs) and induced pluripotent stem cells (ipscs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than ...
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Capability of small-sized stem cells to stimulate hair growth and use thereof
Medipost Co., Ltd.
January 11, 2018 - N°20180008531

Provided are a composition for preventing hair loss and stimulating hair growth, which includes small-sized stem cells, particularly, small-sized stem cells having a diameter of 8 μm or less, or a culture thereof as an active ingredient, a method of preparing the same, and a use of the same. Provided is a use of the composition utilizing a hair ...
Scaffold for alloprosthetic composite implant
Mako Surgical Corp.
January 11, 2018 - N°20180008418

An alloprosthetic composite implant comprising includes a structural porous scaffold having a pore density profile corresponding to a density profile of bone to be replaced. A plurality of cells are seeded within pores of the porous scaffold and grown by incubation. The cells may include osteoblasts and/or stem cells to form the structure of the implant, and one or ...
Therapeutic use for alpha1 proteinase inhibitor in hematopoiesis
The Institute For Human Genetics And Biochemistry
January 04, 2018 - N°20180003699

A previously unrecognized fundamental property of α1pi is to regulate the phenotypic composition of circulating and tissue-associated cells derived from hematopoietic stem cells. The present invention comprises screening for various unmodified and modified α1pi's which are useful in the treatment of abnormalities in the number of cells of myeloid or lymphoid lineage that are associated with ...
Chemical approaches for generation of induced pluripotent stem cells
The Scripps Research Institute
January 04, 2018 - N°20180002671

The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
Efficient induction of definitive endoderm from pluripotent stem cells
Takara Bio Europe Ab
January 04, 2018 - N°20180002668

The present invention relates to a method to differentiate pluripotent stem cells to a primitive streak cell population, in a stepwise manner for further maturation to definitive endoderm.
Purification of germ stem cells by targeting mrp9
President And Fellows Of Harvard College
January 04, 2018 - N°20180002662

Provided herein are methods and compositions for the purification and detection of germ stem cells (e. G., oogonial stem cells) based on expression of mrp9.
Genetically modified mesenchymal stem cells expressing alpha-1 antitrypsin (aat)
Apceth Gmbh & Co. Kg
January 04, 2018 - N°20180000969

Genetically modified mesenchymal stem cells can be used as a medicament in the treatment of medical conditions associated with inflammation and/or an unwanted immune response in subjects without an alpha1-antitrypsin (aat) deficiency. The stem cells include an exogenous nucleic acid, which includes (i) an alpha-1 antitrypsin (aat) encoding region operably linked to (ii) a promoter or promoter/enhancer ...
Methods for inhibiting alpha-v beta-3 expression on cancer stem cells and inhibiting progression to a ...
The Regents Of The University Of California
January 04, 2018 - N°20180000821

In alternative embodiments, provided are compositions and methods for treating, enhancing the drug sensitivity of, and preventing the formation of cancer stems cells, including preventing or slowing the development or generation of a beta-3 (β3)-expressing, or integrin β3 (itg-b3)-expressing cancer or tumor cells. In alternative embodiments, provided are methods using histone acetyl transferase inhibitors and/or ...
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