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Stem Cells

Stem Cells-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Method for evaluating quality of human mesenchymal stem cell, and monoclonal antibody for use in ...
July 20, 2017 - N°20170204374

From a cell population containing human mesenchymal stem cells, rapidly proliferating human mesenchymal stem cells are isolated, selected and cultured. The abundance ratio of cells expressing ror2 or fzd5 in the cell population thus isolated, selected and cultured is quantified to determine whether or not each cell population is acceptable.
Nuclear transfer
Sung Kwang Medical Foundation
July 20, 2017 - N°20170204369

The present invention provides methods and compostions to improve the efficiency of somatic cell nuclear transfer (scnt). There is increasing evidence that the epigenetic state of donor nuclei has a significant impact on potential of nuclear transfer embryos to develop into blastocysts, from which pluripotent stem cells are derived. Strategic application of histone agents, capable of altering epigenetic state such ...
Derivation of embryonic stem cells
Astellas Institute For Regenerative Medicine
July 20, 2017 - N°20170204368

This present invention provides novel methods for deriving embryonic stem cells, those cells and cell lines, and the use of the cells for therapeutic and research purposes without the destruction of the embryo. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e. G., in conjunction with reproductive ...
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Bioreactor system for stem cell expansion
Synthecon, Inc.
July 20, 2017 - N°20170204358

A bioreactor system for stem cell expansion has a fluid-filled reactor chamber in which stem cells are cultured. The culture compartment of the reactor chamber is transversed by a perfusion core with multiple niche-like scaffolds positioned along the length of the perfusion core. The bioreactor system also uses a media gas exchange module that is free standing and does not ...
Mesenchymal stem cells expressing biomarkers that predict the effectiveness of mesenchymal stem cells for treating ...
Temple Therapeutics, Inc.
July 20, 2017 - N°20170204151

Isolated mesenchymal stem cells, which produce mrna encoding tsg-6 protein or a biologically active fragment, derivative, or analogue thereof in an amount of at least a first preselected amount, or produce mrna encoding tsg-6 protein or a biologically active fragment, derivative, or analogue thereof in an amount that does not exceed a second preselected amount, as determined by an assay, ...
In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (pec) and endocrine cells
Viacyte, Inc.
July 20, 2017 - N°20170202885

A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described. Immature beta cells co-express ins and nkx6. 1 and are uni-potent and thereby develop into mature beta cells when implanted in vivo. The mature beta cells in vivo are capable ...
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Stem Cells Patent Applications
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Artificial meniscus
The Johns Hopkins University
July 20, 2017 - N°20170202672

An artificial meniscus using a thermoplastic for the base material, which is reinforced with an inert material. In a preferred embodiment, the reinforcement is provided by kevlar® fibers, and the matrix is made out of polycarbonate-urethane (pcu). In an alternate embodiment, the pcu can also be surrounded by a polycaprolactone (pcl) scaffold that is infused with human growth proteins ...
Identification of cancer stem cells markers and use of same for diagnosis and treatment
The Johns Hopkins University
July 13, 2017 - N°20170199195

Wherein an increase in the amount of the antigen in the first population of tumor cells as compared to the amount of the antigen in the second population of tumor cells is indicative of a cancer stem cell marker in the human primary tumor.
Culture medium and culturing method for anchorage-dependent cells, cell composition including stem cells and/or ...
Kyowa Hakko Kirin Co., Ltd.
July 13, 2017 - N°20170198262

As a technique capable of culturing anchorage-dependent cells without using an anchorage, provided is a medium for anchorage-dependent cells, which comprises mfg-e8 (milk fat globule-egf factor 8) or a fragment of the protein. This medium can promote adhesion of anchorage-dependent cells in the absence of an anchorage, enables the survival and proliferation (colony formation) of the cells, and further, also enables ...
Culture medium for mesenchymal stem cells
Kyoto University
July 13, 2017 - N°20170198258

Mesenchymal stem cells may be culture for a long period, without using any special apparatus, equipment and the like, in a medium in which seven kinds of nonessential amino acids of glycine, alanine, serine, proline, asparagine, aspartic acid, and glutamic acid are reduced.
Encapsulation and cardiac differentiation of hipscs in 3d peg-fibrinogen hydrogels
Auburn University
July 13, 2017 - N°20170198256

The present invention relates to the production of cell cultures and tissues from undifferentiated pluripotent stem cells using three-dimensional biomimetic materials. The resultant cell cultures or tissues can be used in any of a number of protocols including testing chemicals, compounds, and drugs. Further, the methods and compositions of the present invention further provide viable cell sources and novel cell ...
Novel agents and uses thereof
Cantargia Ab
July 13, 2017 - N°20170198048

The present invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (il1rap) for use in inducing cell death and/or inhibiting the growth and/or proliferation of pathological stem cells and/or progenitor cells associated with a neoplastic hematologic disorder, wherein the cells express il1rap. A related aspect of the ...
Reducing cxcr4 expression and/or function to enhance engraftment of hematopoietic stem cells
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
July 13, 2017 - N°20170196911

Provided herein are methods of enhancing engraftment of hematopoietic stem cells (hsc) in recipient subjects by reducing expression (or activity) of cxc chemokine receptor 4 (cxcr4). Such methods can be used in gene therapy protocols and in hsc transplantation, for example allowing this to occur without radiation or chemotherapy conditioning as is typically done in non-myeloablative hsc transplant. In some examples, ...
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Stem Cells Patent Applications
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  • 656+ full patent PDF documents of Stem Cells-related inventions.
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Method of cryopreservation of stem cell-derived retinal pigment epithelial cells on polymeric substrate
University Of Southern California
July 13, 2017 - N°20170196221

Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.
Rna editing biomarkers for diagnosis, pharmacological screening and prognostication in cancer
Regents Of The University Of California
July 06, 2017 - N°20170191057

Compositions and methods for expanding cd34+ cells, performing research related to cancer stem cells, rna-editing enzymes and for monitoring, diagnosing and treating, ameliorating and preventing diseases such as cancers or inflammatory diseases.
Tgfß signaling independent naÏve induced pluripotent stem cells, methods of making and ...
Beijing Vitalstar Biotechnology Co., Ltd.
July 06, 2017 - N°20170191038

Provided is a cocktail of factors for converting/reprogramming non-naïve pluripotent stem cells into tgfβ signaling-independent (tsi) naïve induced pluripotent stem cells (ipscs). Also provided are methods for reprograming a non-naïve psc into a tsi naïve ipsc by contacting the cell to be reprogrammed with effective amounts of compounds for ...
Method for culturing mesenchymal stem cells
Medipost Co., Ltd.
July 06, 2017 - N°20170191036

Disclosed is a method for culturing mesenchymal stem cells, comprising culturing mesenchymal stem cells in a medium containing calcium in a concentration of from 2. 1 to 3. 8 mm and magnesium in a concentration of from 1. 0 to 3. 0 mm under a hypoxic condition of 2 to 5% oxygen. The culturing method can increase the population of mesenchymal stem cells even with a small number of passages ...
A method to up-regulate cancer stem cell markers for the generation of antigen specific cytotoxic ...
Tessa Therapeutics Pte. Ltd.
July 06, 2017 - N°20170191034

The invention concerns a method of preparing a composition comprising stimulated immune system cells such as dendritic cells (dc) for use in inducing immune response of cytotoxic t lymphocytes against colorectal cancer. The dendritic cells are pulsed by contact with colorectal cancer stem cells (csc) or their fragments thereof. These colorectal cscs are produced by oskm (oct4, sox2, klf4 and ...
Method for preparation of retinal ganglion cells
Tessa Therapeutics Pte. Ltd.
July 06, 2017 - N°20170191033

The present invention provides a method for inducing pluripotent stem cells to differentiate into retinal ganglion cells that can be used for clinical application. Such method is a method for producing retinal ganglion cells with elongated axons comprising the following steps: (a) a step of inducing pluripotent stem cells to differentiate into retinal progenitor cells via floating culture; (b) a ...
Identification and isolation of neural stem cells and neurosphere initiating cells
The Board Of Regents Of The University Of Texas System
July 06, 2017 - N°20170191032

The disclosure reports on the identification and isolation of adult mouse lateral ventricle subventricular zone (svz) neurosphere initiating cells (nics) by flow cytometry on the basis of glastmidegfrhighplexinb2highcd24−/lowo4/psa-ncam−/lowter-119/cd45− markers (gepcot cells). These cells are highly mitotic and short-lived in vivo based on fate-mapping with ascl1creert2 and dlx1creert2. In contrast, pre-gepcot ...
Systems and methods for stem cell differentiation
University Of Oslo
July 06, 2017 - N°20170191031

The present invention relates to compositions and method for differentiating stem cells. In particular, the present invention relates to methods of generating hepatocytes from human pluripotent stem cells (hpscs) using a small molecule-driven approach.
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