|| List of recent Spectrometer-related patents
|Method for the laser spectroscopy of gases|
A method of determining a concentration of a gas in a sample and/or the composition of a gas using a spectrometer comprises the transmitting of radiation whose wavelength substantially continuously runs through a wavelength range, wherein the continuous running through of the wavelength range is overlaid by a wavelength modulation; the measuring of an absorption signal from the absorption of the radiation by the gas as a function of the wavelength of the radiation; the converting of the absorption signal into a first and a second derivative signal; the deriving of a first measured gas concentration value from the first derivative signal and of a second measured gas concentration value from the second derivative signal; and the determining of the concentration and/or the composition of the gas from at least the first measured gas concentration value, wherein the wavelength modulation is adapted in response to a change of a state variable of the gas such that a ratio between the first measured gas concentration value and the second measured gas concentration value is kept substantially constant.. .
|Apparatus and method for mobile device camera testing|
A mobile device testing system with a sphere assembly is disclosed. The sphere assembly is a source integrating sphere and a test integrating sphere connected by an optical channel.
|Medication assurance system and method|
A medication assurance system for verification of both the medication and the patient is disclosed. A portable spectrometer is used to obtain a light spectrum of the medication.
A mass spectrometer including chromatogram creation means for creating a chromatogram showing changes over time in an ion intensity within a predetermined mass range based on the ms analysis results, and timing determination means for determining a timing to perform ms/ms analysis based on the chromatogram. The timing determination means determines, as a timing to perform ms/ms analysis, a point in time at which a signal intensity in the chromatogram reaches a predetermined upper limit after exceeding a predetermined lower limit or a point in time at which a signal intensity in the chromatogram reaches a top of a peak without reaching the upper limit after exceeding the lower limit.
|High resolution time-of-flight mass spectrometer|
Mass spectrometers and related methods of making and using the same are disclosed herein that generally involve positioning a blocking or masking element in the path of an ion beam passing through the mass spectrometer so as to selectively block at least a portion of the ions in the ion beam from entering an accelerator. Mass spectrometers and related methods are also disclosed in which an ion beam passing through the mass spectrometer is deflected or otherwise aimed so as to approach a tof axis of an accelerator at a non-zero angle..
|Mass spectrometer vacuum interface method and apparatus|
A method of operating a mass spectrometer vacuum interface comprising a skimmer apparatus having a skimmer aperture and downstream ion extraction optics. An expanding plasma is skimmed through the skimmer aperture.
|Systems, devices, and methods for sample analysis using mass spectrometry|
A mass spectrometry system for screening a sample for one or more analytes includes a pre-mass spectrometry screening apparatus configured to pre-screen an ionized sample to generate output correlated to the composition of the sample, and a mass spectrometer. A sample gate is opened to allow flow of at least a portion of the ionized sample to the mass spectrometer and closed to prevent flow of the ionized sample to the mass spectrometer.
|Method of compensating frequency drift in an interferometer|
A method of compensating for frequency drift of a reference energy source in an ft interferometer based spectrometer instrument, the method further comprising comparing in an arithmetic unit data representing a reference interferogram and data representing a target interferogram to determining a phase shift between the interferograms in a window w in at least one region away from center-burst and generating in the arithmetic unit a mathematical transform dependent on the determined shift or shifts to be subsequently applied to control the operation of the spectrometer instrument in order to generate data representing a frequency stabilized interferogram of an unknown sample recorded by the ft interferometer.. .
|Identification of related peptides for mass spectrometry processing|
A method of identifying a related peak set from ms1 spectra data is provided. An intensity peak is selected from ms1 spectra data generated for a sample by a tandem mass spectrometer.
|Method of determining catalytic fines in an oil|
The system comprises a nmr spectrometer, a digital memory storing a calibration map comprising calibrating data for calibrating nmr spectra obtained by the nmr spectrometer and a computer programmed to analyze the nmr spectra obtained by the nmr spectrometer using calibration map and performing at least one quantitative and/or qualitative catalytic fines determination.. .
|Ionization at intermediate pressure for atmospheric pressure ionization mass spectrometers|
An ion source able to ionize liquid and gaseous effluents from interfaced liquid or gaseous separation techniques and from direct introduction of the analyte to the entrance of the ionization region. The liquid effluents from sources such as a liquid chromatograph are ionized by inlet ionization methods and the gaseous effluents from sources such as a gas chromatograph are ionized by a corona or townsend electrical discharge, or an alpha or beta emitter, or by inlet ionization, or by photoionization.
|Mass spectrometer arranged to perform ms/ms/ms|
A mass spectrometer is disclosed comprising an on trap and a fragmentation device. Ions are fragmented in the on trap to form first generation fragment ions.
|Use of windowed mass spectrometry data for retention time determination or confirmation|
A scan of a separating sample is received by a mass spectrometer at each interval of a plurality of intervals. The spectrometer performs at each interval one or more mass spectrometry scans.
|Apparatus and method relating to an improved mass spectrometer|
The present disclosure provides a mass spectrometer including means for producing a primary beam of ions for bombarding a sample under vacuum and a detector for detecting a secondary beam of ions released from the sample. The primary beam of ions includes a gaseous mixture of a cluster forming gas and one or more hydrogen-rich hydrocarbons..
|Mass spectrometer vacuum interface method and apparatus|
A method of preparing or operating a mass spectrometer vacuum interface comprising a skimmer apparatus having a skimmer aperture and an internal surface of the skimmer apparatus, comprising disposing an adsorbent or getter material on the internal surface. The internal surface has a deposition region where matter from plasma flows may be deposited and the material is disposed on part or all of the deposition region.
|Mechanism for movement of a mirror in an interferometer, an interferometer incorporating the same and a fourier transform spectrometer incorporating the same|
A mechanism that allows for precise motion of the optics of an interferometer is comprised by two or more diaphragm flexures having high lateral stiffness, creating a superior performing michelson interferometer. When coupled with precise precision control of a mirror surface and a reference laser, the above creates a superior performing fourier transform spectrometer..
After a first injection of a sample, amount of change between a highest intensity and each of two ion intensities before and after a voltage showing the highest intensity is calculated for each ce voltage. If the change is equal to or less than a threshold the ce voltage showing the highest intensity in the coarse control mode is selected as the optimal value, without performing a measurement in a fine control mode.
|Atmospheric pressure ion source for mass spectrometry|
A multiple function atmospheric pressure ion source interfaced to a mass spectrometer comprises multiple liquid inlet probes configured such that the sprays from two or more probes intersect in a mixing region gas phase sample ions or neutral species generated in the spray of one probe can react with reagent gas ions generated from one or more other probes by such ionization methods as electrospray, photoionization, corona discharge and glow discharge ionization. Reagent ions may be optimally selected to promote such processes as atmospheric pressure chemical ionization of neutral sample molecules, or charge reduction or electron transfer dissociation of multiply charged sample ions.
|High duty cycle ion spectrometer|
An ion spectrometer is provided, comprising: an ion source, arranged to generate ions continuously with a first range of mass to charge ratios; and an ion trap, arranged to receive ions from the ion source along an axis, and to eject ions with a second range of mass to charge ratios orthogonally to that axis, the second range of mass to charge ratios being narrower than the first range of mass to charge ratios. In some embodiments, ions generated by the ion source continuously flow into the ion trap.
A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised.
|Methods, apparatus, and system for mass spectrometry|
A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 amu. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments.
|Diathermy knife ionisation source|
A method of detecting one or more compounds, chemicals or contaminants in a substrate by mass spectrometry is disclosed. A non-living substrate is analysed by contacting the substrate with a diathermy knife.
A mass spectrometer is disclosed comprising an electron transfer dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell.
|Low-cost spectrometry system for end-user food analysis|
A compact spectrometer is disclosed that is suitable for use in mobile devices such as cellular telephones. In preferred embodiments, the spectrometer comprises a filter, at least one fourier transform focusing element, a micro-lens array, and a detector, but does not use any dispersive elements.
|Cavity enhanced absorption spectroscopy with a laser modulation side-band frequency locked to the cavity|
A cavity enhanced absorption spectrometer (ceas) and method for controlling the same. The ceas includes a coherent electro-magnetic radiation source, an electro-magnetic modulator that creates a sideband with an adjustable frequency that is offset from the radiation source frequency by imparting an adjustable frequency modulation to the radiation.
|Snapshot spectral domain optical coherence tomographer|
Provided is a snapshot spectral domain optical coherence tomographer comprising: a light source providing a plurality of beamlets; a beam splitter, splitting the plurality of beamlets into a reference arm and a sample arm; a first optical system that projects the sample arm onto multiple locations of a sample; a second optical system for collection of a plurality of reflected sample beamlets; a third optical system projecting the reference arm to a reflecting surface and receiving a plurality of reflected reference beamlets; a parallel interferometer that provides a plurality of interferograms from each of the plurality of sample beamlets with each of the plurality of reference beamlets; an optical image mapper configured to spatially separate the plurality of interferograms; a spectrometer configured to disperse each of the interferograms into its respective spectral components and project each interferogram in parallel; and a photodetector providing photon quantification.. .
There is provided an ion reflector for use with a mass spectrometer for directing a flow of ions between two distinct axes of travel. The reflector includes an electric field capable of causing a flow of ions focused through a first spatial region to be focused toward a second spatial region, whereby the first and second spatial regions are aligned with respective axes of travel..
|Long-path infrared spectrometer|
A tunable mid-infrared laser operated in a pulsed mode is coupled off-axis into a high-finesse optical cavity to produce a long-path spectrometer. The cavity receives a gas sample.
|System and method for applying curtain gas flow in a mass spectrometer|
A system of mass spectrometry is disclosed having an ion source for generating ions at substantially atmospheric pressure. The system has a sampling member with an orifice disposed therein.
|Asymmetric field ion mobility spectrometer|
The present invention discloses an asymmetric field ion mobility spectrometer. It comprises an ionization source, for generating ions; an electrode plate; a plurality of electrode filaments, arranged in opposite to and spaced apart from the electrode plate by an analysis gap, wherein a high voltage of electrical field is applied between the electrode plate and the electrode filaments to form an ion migration area, the electrode filaments used to collect the ions that do not pass through the ion migration area; and a collection electrode, disposed at a rear end of the ion migration area, and collecting the ions that have passed through the ion migration area.
|Intelligent background data acquisition and subtraction|
A scan of a separating sample mixture is received from a mass spectrometer at each interval of a plurality of intervals. It is determined at a first interval that a received mass spectrometry scan at the first interval and one or more preceding received mass spectrometry scans include a varying ion signal that represents an ion of a known compound and has an intensity above a threshold level.
|Low cross-talk fast sample delivery system based upon acoustic droplet ejection|
An ion source for a mass spectrometer is disclosed comprising an ultrasonic transducer which focuses ultrasonic energy onto a surface of a sample fluid without directly contacting the sample fluid.. .
|Apparatus and method relating to an improved mass spectrometer|
A mass spectrometer comprising means for producing a primary beam of ions for bombarding a sample under vacuum, and a detector for detecting a secondary beam of ions released from the sample. The primary beam of ions includes water clusters where each water cluster contains between 1 and 10,000 water molecules..
|Ion mobility spectrometer with device for generating ammonia gas|
The present invention relates to ion mobility spectrometry, in particular to methods and devices for generating and delivering of ammonia gas as dopant into the ionization region of an ion mobility spectrometer. It provides an ion mobility spectrometer (ims) with an ion source and device for generating ammonia gas, wherein the device comprises a dopant reservoir filled with alkali metal nitride or alkaline earth metal nitride, preferably lithium nitride and/or magnesium nitride, said reservoir being fluidly coupled to the ion source and to a water reservoir..
|Substance detection device utilizing a cyclone particle separator|
A substance detection device, including a chemical substance analyzer, including an ion mobility spectrometer (ims), a desorber, a conduit, and a membrane. The membrane extends across a cross-section of the conduit, and the membrane is positioned to have a desorber side in gas communication with the desorber and an analysis side opposite the desorber side.
|Imaging mass analysis data processing method and imaging mass spectrometer|
If spatial measurement point intervals in imaging mass analysis data of two samples to be compared are different and the degrees of spatial distribution spreading of substances are compared, one of the data is defined as a reference, the measurement point intervals in the other of the data are redefined so as to be equalized to the reference, and a mass spectrum at each virtual measurement point set as a result of the redefinition is obtained through interpolation or extrapolation based on a mass spectrum at an actual measurement points. If the arrays of the m/z values of mass spectra are different for each sample, the m/z value positions of the mass spectrum in one of the data are defined as a reference, and the intensity values corresponding to the reference m/z values are obtained through interpolation or extrapolation for the mass spectrum of the other of the data..
|Apparatus and method for monitoring a thickness of a silicon wafer with a highly doped layer|
Apparatus for monitoring a thickness of a silicon wafer with a highly-doped layer at least at a backside of the silicon wafer is provided. The apparatus has a source configured to emit coherent light of multiple wavelengths.
|Capturing of cell fluid and analysis of its components under observation of cells and instruments for the cell fluid capturing and the analysis|
A method captures cellular components from a single cell and performs mass spectrometry on the components. The method includes inserting a nanospray ionization capillary tip into a specific region of the cell under observation with a microscope.
|Chemical ionization with reactant ion formation at atmospheric pressure in a mass spectrometer|
The invention relates to the production of water cluster ions (“hydronium clusters”) at atmospheric pressure for the chemical ionization of analyte molecules. It is proposed that a corona discharge at the taylor cone of an aqueous liquid, preferably pure or slightly acidified pure water, is used instead of corona discharges on metal tips, which have been the usual method up to now.
|Linearized variable-dispersion spectrometers and related assemblies|
Wavenumber linear spectrometers are provided including an input configured to receive electromagnetic radiation from an external source; collimating optics configured to collimate the received electromagnetic radiation; a dispersive assembly including first and second diffractive gratings, wherein the first diffraction grating is configured in a first dispersive stage to receive the collimated electromagnetic radiation and wherein the dispersive assembly includes at least two dispersive stages configured to disperse the collimated input; and an imaging lens assembly configured to image the electromagnetic radiation dispersed by the at least two dispersive stages onto a linear detection array such that the variation in frequency spacing along the linear detection array is no greater than about 10%.. .
|Gaseous sample injection valve and gaseous sample injection method using same|
The present invention relates to a gaseous sample injection valve. The gaseous sample injection valve includes a middle body injecting a fixed amount of a gaseous sample into the vacuum chamber of a mass spectrometer, the middle body being constituted by a gaseous sample injection tube, a gaseous sample discharge tube, a storage part, and a vacuum chamber connection tube; an upper body accommodating a first solenoid coil, a first plunger, and a first packing; and a lower body accommodating a second solenoid coil, a second plunger, and a second packing.
|Simultaneous inorganic mass spectrometer and method of inorganic mass spectrometry|
An inorganic mass spectrometer capable of measuring a relevant and large or the full mass spectral range simultaneously may include a suitable ion source (e.g., an icp mass spectrometer with an icp ion source), an ion transfer region, ion optics to separate ions out of a plasma beam, a mattauch-herzog type mass spectrometer with a set of charged particle beam optics to condition the ion beam before an entrance slit, and a solid state multi-channel detector substantially separated from ground potential and separated from the potential of the magnet.. .
|Signal processing for mass directed fraction collection|
A system and removing noise from a mass spectrometer signal for fraction collection is described herein.. .
|Water-treatment separating membrane of high flux having good chlorine resistance|
A water-treatment separating membrane includes a polyamide active layer formed on999 a porous support. The ratio of a maximum value with respect to a minimum value of a ratio of a peak height of a c=o double bond of a carboxyl group (—cooh) with respect to a peak height of a c=o double bond combined with an amide group (—conh—) is from 1.2 to 4, when measured after acid treating the polyamide active layer and by using a fourier transform infrared spectrometer (ftir)..