This page is updated frequently with new Spectrometer-related patent applications.
| Coupling intermediate pressure regions|
A method is disclosed for coupling a first chamber of a mass spectrometer or ion mobility spectrometer containing a first gas and a second chamber containing a second gas. The method comprises providing an intermediate region between the first and second chambers that is operated at a lower pressure to substantially prevent or reduce ingress of the first gas into the second chamber and/or of the second gas into the first chamber..
Micromass Uk Limited
| Systems and methods for analyzing an extracted sample using an immiscible extraction solvent|
The invention generally relates to systems and methods for analyzing an extracted sample using an immiscible extraction solvent. In certain embodiments, the invention provides a system for analyzing an analyte in a sample.
Purdue Research Foundation
| An imaging spectrometer design tool for evaluating freeform optics|
A full-field display for spectrally dispersive imaging optics, particularly as a design tool for evaluating optical designs including designs with freeform optical surfaces, includes a ray tracing module arranged for modeling local aberrations throughout the image field of the spectrometer and a display module that converts values of the modeled local aberrations throughout the image field into representative symbols. The spectrometer field has a first spatial dimension corresponding to a length dimension of an input and a second spectral dimension corresponding to the dispersion of the input.
University Of Rochester
| Method for measuring human exhaled air|
A method for measuring human exhaled air by means of gas chromatography and ion mobility spectrometry, wherein an exhaled air sample enters a sample loop via a sample inlet and a multi-port valve and is subsequently conveyed by means of a carrier gas from the sample loop, via the multi-port valve through a gas chromatographic column, into an ion mobility spectrometer, and measured, which method is to provide reliable and accurate measurement results. This object is achieved in that the following steps are carried out before an exhaled air sample is introduced into the sample loop: (a) first flushing at least the gas chromatographic column, the ion mobility spectrometer and the sample loop with a flushing gas and then switching the multi-port valve in such a way that the flushing gas enters the ion mobility spectrometer and is measured; (b) then stopping the supply of flushing gas and switching the multi-port valve in such a way that ambient air flows through the gas chromatographic column into the ion mobility spectrometer and is measured; (c) then flushing at least the gas chromatographic column, the ion mobility spectrometer and the sample loop with humidified flushing gas and switching the multi-port valve in such a way that the humidified flushing gas enters the ion mobility spectrometer and is measured; and (d) subsequently stopping the supply of humidified flushing gas, conducting an exhaled air sample into the sample loop, conveying the sample, by means of the carrier gas, through the gas chromatographic column into the ion mobility spectrometer, and measuring the sample..
Imspex Diagnostics Ltd
| Approximation algorithm for solving a momentum transfer cross section|
The present invention comprises a method for automated, high throughput molecular identification of macromolecular organic compounds. The method may provide an approximate solution to a momentum transfer cross section of an analyte in a buffer gas as measured by an ion mobility spectrometer that has low computational demand, has a high level of accuracy, and is adaptable for a variety of drift gases..
The Florida State University Research Foundation, Inc.
| Air dryer for ion mobility spectrometer|
Embodiments of the present invention provide an air dryer for an ion mobility spectrometer, comprising a heating element used to heat a thermal conduction device, thereby heating the desiccant. Embodiments of the present invention further provide a regeneration method, by which the operation mode of the ion mobility spectrometer may be switched, so that during a non-working time of the ion mobility spectrometer, the desiccant is heated and thereby regenerated.
Nuctech Company Limlted
| Rapid lc mapping of cov values for selexion technology using mrm-triggered mrm functionality|
Mrm triggered mrm, where the triggered mrm transitions make use of mobility device parameter values for the same compound, is performed. A plurality of primary mrm transitions are received and stored together with a mobility device parameter value for each transition as an mrm cycle list.
Dh Technologies Development Pte. Ltd.
| Bio-chip package with waveguide integrated spectrometer|
A bio-chip package comprises a substrate a first layer over the substrate comprising an image sensor. The bio-chip package also comprises a second layer over the first layer.
Taiwan Semiconductor Manufacturing Company, Ltd.
| Carbon isotope analysis device and carbon isotope analysis method|
Provided are a simple and convenient apparatus capable of analyzing carbon isotope 14c and a method of analyzing the carbon isotope. A carbon isotope analyzer 1 including an isotopic carbon dioxide generator 40 to generate isotopic carbon dioxide from a carbon isotope; a spectrometer 10 including an optical resonator 11 having a pair of mirrors 12, and a photodetector 15 to determine the intensity of light transmitted from the optical resonator 11; and a light generator 20 including a light source 23, a first optical fiber 21 to transmit a light beam from the light source 23, a second optical fiber 22 for wavelength conversion, the second optical fiber 22 branching from the first optical fiber 21 at a point and combining with the first optical fiber 21 at another point downstream of the branching point, and a non-linear optical crystal 25 to generate light having the absorption wavelength of the isotopic carbon dioxide on the basis of the difference in frequency between light beams transmitted through the optical crystal 25..
National University Corporation Nagoya University
| Spectrometer, monochromator, diffraction grating and methods of manufacturing grating and mold|
A diffraction grating comprise a substrate and a plurality of connected diffraction structures formed on the substrate. Each diffraction structure is in the shape of a column and arranged along a concave cylindrical surface, and an axis of each diffraction structure extends along a generatrix of the concave cylindrical surface.
Oto Photonics Inc.
Tandem quadrupole mass spectrometer
A dwell time calculation table (51a) showing a correspondence relation between a cid gas pressure inside a collision cell (31) and a dwell time for data collection is stored in a processing condition parameter memory (51) of a controller (50). In the table (51a), as the cid gas pressure becomes higher, the dwell time becomes longer.
Electrostatic mass spectrometer with encoded frequent pulses
A method, apparatus and algorithms are disclosed for operating an open electrostatic trap (e-trap) or a multi-pass tof mass spectrometer with an extended flight path. A string of start pulses with non equal time intervals is employed for triggering ion packet injection into the analyzer, a long spectrum is acquired to accept ions from the entire string and a true spectrum is reconstructed by eliminating or accounting overlapping signals at the data analysis stage while using logical analysis of peak groups.
Multi-oscillator, continuous cody-lorentz model of optical dispersion
Methods and systems for monitoring band structure characteristics and predicting electrical characteristics of a sample early in a semiconductor manufacturing process flow are presented herein. High throughput spectrometers generate spectral response data from semiconductor wafers.
Ion mobility spectrometer
There is provided a method of separating ions comprising operating an ion mobility spectrometer or separator at a reduced pressure and at an operating temperature less than 40° c., and providing a drift gas within said ion mobility spectrometer or separator, wherein said drift gas comprises one or more substances that exist as a liquid at atmospheric pressure (optionally about 1013 mbar) and room temperature (optionally about 20° c.) and wherein said one or more substances have a boiling or sublimation point less than said operating temperature of said ion mobility spectrometer or separator, at said reduced pressure.. .
Micromass Uk Limited
Method for analysis using x-ray fluorescence
The present invention is a method to quantify biomarkers. The method uses an x-ray fluorescence spectrometer to perform an x-ray fluorescence analysis on the sample to obtain spectral features derived from the biomarker; and quantifying the x-ray fluorescence signal of the biomarker..
Spectrometer and gas analyzer
A spectrometer has an entry aperture for coupling in electromagnetic radiation to be spectroscope, a refractive or diffractive optical element arranged such that electromagnetic radiation which is coupled in through the entry aperture is incident on the refractive or diffractive optical element to be spectrally split there, and at least two individual detectors which, for the detection of different spectral ranges of the split electromagnetic radiation, are arranged next to one another in the direction of the spectral splitting of the electromagnetic radiation. Electromagnetic radiation from a predetermined ultraviolet wavelength range is directed onto one of the individual detectors by the optical element and electromagnetic radiation from a predetermined blue wavelength range is directed onto another of the detectors by the optical element.
System and performing tear film structure measurement and evaporation rate measurements
A system and method are described for performing tear film structure measurement. A broadband light source illuminates the tear film.
Adom, Advanced Optical Technologies Ltd
Analyser arrangement for particle spectrometer
The present invention relates to a method for determining at least one parameter related to charged particles emitted from a particle emitting sample, e.g. A parameter related to the energies, the start directions, the start positions or the spin of the particles.
Scienta Omicron Ab
Systems and methods for ion isolation
A mass spectrometer includes a radio frequency ion trap and a controller. The controller is configured to cause an ion population to be injected into the radio frequency ion trap and supply an isolation waveform to the radio frequency ion trap.
Thermo Finnigan Llc
Systems and methods for ion isolation using a dual waveform
A mass spectrometer includes a radio frequency ion trap; and a controller. The controller is configured to cause an ion population to be injected into the radio frequency ion trap; supply a first isolation waveform to the radio frequency ion trap for a first duration, and supply a second isolation waveform to the radio frequency ion trap for a second duration.
Thermo Finnigan Llc
Systems and methods for delivering liquid to an ion source
Methods and systems for delivering a liquid sample to an ion source are provided herein: in various aspects, the methods and systems described herein can utilize the flow provided by an lc pump(s) to drive a calibration fluid to an ion source of a mass spectrometer system. In various aspects, methods and systems described herein can additionally or alternatively be placed upstream of an lc column for providing an elution gradient of a plurality of solvents, without requiring a plurality of pumps and/or separate mixing elements..
Dh Technologies Development Pte. Ltd.
Auxiliary gas inlet
There is provided a method of introducing ions into a mass spectrometer, comprising ionising a sample using a matrix assisted laser desorption ionisation (“maldi”) ion source to form a plurality of ions, transporting said plurality of ions in a first, primary gas through a passageway and into an inlet of a mass spectrometer, introducing a second, auxiliary gas into said inlet, and controlling a flow rate of said second gas into said inlet so as to control a flow rate of said first gas through said passageway.. .
Micromass Uk Limited
Auxiliary gas inlet
There is provided a method of introducing ions into a mass spectrometer, comprising ionising a sample using a continuous ionisation source to form a plurality of ions, transporting said plurality of ions in a first, primary gas through a passageway and into an inlet of a mass spectrometer, introducing a second, auxiliary gas into said inlet, and controlling a flow rate of said second gas into said inlet so as to control a flow rate of said first gas through said passageway.. .
Micromass Uk Limited
Jet injector inlet for a differential mobility spectrometer
A method and apparatus for performing differential mobility spectrometer (dms) which includes decreasing the amount of time that ions spend inside fringing fields generated by the dms. The apparatus includes an entrance electrode plate sealingly engaged to the entrance of the dms, and is electrically separated from the parallel plate electrodes of the dms, the entrance electrode plate has an aperture for allowing the traversal of ions into the dms; wherein the cross-sectional area of the aperture is less than the cross-sectional area of the ion path, the ion path being located between the two parallel plate electrodes of the dms.
Dh Technologies Development Pte Ltd.
Pressure driven microfluidic injection for chemical separations
Methods that allow independently applied pressures to a bge reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods are particularly suitable for use with a mass spectrometer..
The University Of North Carolina At Chapel Hill
Laser induced breakdown spectroscopy (libs) apparatus with dual ccd spectrometer
This invention discloses a compact laser induced breakdown spectroscopy (libs) apparatus suitable for field operations. The libs apparatus comprises a q-switched laser with laser pulse energy between several tens and several thousands of micro joules (μj), which is significantly lower than that of traditional libs lasers.
Bwt Property, Inc.
Spectrometer insert for measuring temperature-dependent optical properties
In one aspect, a spectrometer insert is provided. The spectrometer insert includes: an enclosed housing; a first transparent window on a first side of the enclosed housing; a second transparent window on a second side of the enclosed housing, wherein the first side and the second side are opposing sides of the enclosed housing; and a sample mounting and heating assembly positioned within an interior cavity of the enclosed housing in between, and in line of sight of, the first transparent window and the second transparent window.
International Business Machines Corporation
Mass spectrometer and mass spectrometry method
A mass spectrometer including an ionization source including an esi probe (201), an esi power source (24), a corona needle (202) and an apci power source (24); an ionization condition storage section (41) for storing a plurality of ionization conditions related to the liquid sample, set by an analysis operator, with the ionization conditions differing from each other in the value of the esi voltage or/and the value of the apci voltage; a mass spectrometry executer (43) for conducting a mass spectrometry for an ion generated from the liquid sample using each of the plurality of ionization conditions; and a mass spectrometry result selector (44) for selecting, for each of the one or plurality of components, a mass spectrometry result in which the ion is detected with a suitable level of intensity for an analysis, from the mass spectrometry results respectively obtained for the plurality of ionization conditions.. .
Homogenization of the pulsed electric field created in a ring stack ion accelerator
A ring stacked accelerator for use in a mass spectrometer includes a plurality of ring shaped plates arranged in a stack and is electrically coupled to a voltage divider that allows a substantially homogeneous electric field to be produced when the stack is energized. The voltage divider can include resistors and capacitors, where the capacitors are chosen to compensate for parasitic capacitances experienced by the plates.
Dh Technologies Development Pte. Ltd.
The objective of the present invention is to obtain an ms2 spectrum for each of a plurality of different ion species even when their m/z values are extremely close to each other and prevent separate setting of each ion species as the precursor ion. In the vicinity of the target m/z, a precursor-ion selection window covering a predetermined m/z range (2×Δm) is gradually shifted in predetermined steps (Δm) to define a plurality of windows as the condition of the precursor-ion selection.
Optimized design manufacturing fresnel grating
An optimized design method for manufacturing a fresnel grating is disclosed, including the following steps: (1) making a fresnel surface type of the fresnel grating equivalent to a curved surface type, and determining, based on the curved surface type to which the fresnel surface type is equivalent, an optical path difference function of the fresnel grating: Φ (λ)=<ap1p2b>−<aob>+nmλ; and (2) determining a fresnel grating parameter that minimizes a function value of the optical path difference function, so as to manufacture a fresnel grating that has an aberration elimination effect. The manufactured fresnel grating may effectively eliminate a portion of aberrations of the fresnel grating, and increase a resolution of a spectrometer..
Graduate School At Shenzhen, Tsinghua University
Ion mobility analyzer and mass spectrometer
A drift voltage generator applies voltages to a plurality of annular electrodes, respectively, so that a potential distribution φ on an ion beam axis of an accelerating electric field created within a drift region satisfies ∂2φ/∂z2>0. Trailing ions undergo a higher rate of acceleration than preceding ions, so that a compressing force acts on an ion packet in the direction of the ion beam axis.
Spectrometer with random beam profiles
A spectrometer includes a light source configured to emit a beam along a beam path through a sample volume comprising an analyte. Also included is at least one detector positioned to detect at least a portion of the beam emitted by the light source, and at least one reflector positioned along the beam path intermediate the light source and the at least one detector having a surface roughness greater than a predefined level such as 20 Å rms..
An infrared spectrometer includes an entrance slit and a collimating optical element aligned with the entrance slit. A diffractive optical element is optically coupled to the collimating optical element.
Globally optimized targeted mass spectrometry (got-ms)
Globally optimized targeted (got)-ms, combines many of the advantages of targeted detection and global profiling in metabolomics analysis, including the capability to detect unknowns, broad metabolite coverage, and excellent quantitation. A global search of precursor and product ions using a single triple quadrupole (qqq) mass spectrometer includes sim incremental scanning or incremental ms scanning performed in the mass range of 40-2000 da, followed by tandem ms/ms scanning with incremental collision energy for precursor ions to profile product ions..
University Of Washington
System for transferring ions in a mass spectrometer
A system for transporting ions includes: an ion transfer tube having an axis and an internal bore having a width and a height less than the width; and an apparatus comprising a plurality of electrodes, each having a respective ion aperture having an aperture center, the apertures defining an ion channel configured to receive the ions from the ion transfer tube and to transport the ions to an outlet end of the apparatus, wherein at least a subset of the apertures progressively decrease in size in a direction towards the apparatus outlet end, wherein the ion transfer tube is configured such that the ion transfer tube axis is non-coincident with an axis of the ion channel or such that the width dimension of the ion transfer tube bore is parallel to a plane defined by the ion transfer tube axis and the ion channel axis.. .
Thermo Finnigan Llc