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Specificity

Specificity-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Intelligent list reading
Apple Inc.
December 07, 2017 - N°20170352350

Systems and processes for operating an intelligent automated assistant to perform intelligent list reading are provided. In one example process, a spoken user request associated with a plurality of data items is received. The process determines whether a degree of specificity of the spoken user request is less than a threshold level. In response to determining that a degree of ...
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to ...
Massachusetts Institute Of Technology
December 07, 2017 - N°20170349914

The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a crispr complex, as well as ...
Using programmable dna binding proteins to enhance targeted genome modification
Sigma-aldrich Co., Llc
December 07, 2017 - N°20170349913

Compositions and methods for using programmable dna binding proteins to increase the efficiency and/or specificity of targeted genome modification or to facilitate the detection of specific genomic loci in eukaryotic cells.
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Tfr selective binding compounds and related methods
Ossianix, Inc.
December 07, 2017 - N°20170348416

The present invention relates to peptides that bind with high specificity and which functionally interact with the transferrin receptor (“tfr”) and which may be used in making molecular vehicles that carry biomolecules across membranes, including, e. G., across the blood brain barrier or the gastrointestinal tract. Tfr specific binding moieties may also be used alone or ...
Methods and compositions for single chain variable region enox2 antibodies for cancer detection and diagnosis
Mor-nuco Enterprises, Inc.
November 30, 2017 - N°20170343555

Cancers of different cellular or tissue origins express different enox2 cancer isoforms or combinations of isoforms and shed these proteins into the circulation. Herein are disclosed methods both for cancer detection and diagnosis of particular origin, based on the patterns and molecular weights of the isoforms which allow the identification of the cell type and or tissue of origin of ...
Methods of and systems for producing caprylic acid and/or caprylate
Cornell University
November 30, 2017 - N°20170342447

Methods and systems to produce product compositions comprising caprylate products using chain-elongating bacteria. For example, the caprylate product in the product composition is n-caprylic acid (c8) and the n-caprylic (c8) to n-caproic (c6) acid ratio is higher than 1:1. These methods use chain elongation towards c8 rather than c6. High n-caprylate productivity and specificity was accomplished by: 1) feeding a substrate with, ...
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Specificity Patent Applications
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For professional research & prior art discovery
inventor
  • 262+ full patent PDF documents of Specificity-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Multiplex immuno screening assay
Institut Pasteur
November 23, 2017 - N°20170336412

The present invention provides kits and assay methods for the early detection of pathogens, precise identification of the etiologic agent, and improved disease surveillance. More specifically, the present invention discloses an immunoassay leading to the rapid and simultaneous detection of antibodies to a wide range of infectious pathogens in biological fluids of infected patients. This immunoassay involves the covalent and ...
Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity
Duke University
November 23, 2017 - N°20170335299

Rationally-designed laglidadg meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired dna sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics ...
Anti-acth antibodies and use thereof
Alder Biopharmaceuticals, Inc.
November 23, 2017 - N°20170334987

The present invention is directed to antibodies and fragments thereof having binding specificity for acth. Another embodiment of this invention relates to the antibodies binding fragments thereof described herein, comprising the sequences of the vh, vl and/or cdr polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-acth antibodies and binding fragments thereof conjugated ...
Antagonists of il-6 to raise albumin and/or lower crp
Alderbio Holdings Llc
November 23, 2017 - N°20170334986

The present invention is directed to therapeutic methods using il-6 antagonists such as antibodies and fragments thereof having binding specificity for il-6 to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum c-reactive protein level or a reduced serum albumin ...
N-substituted 4-aminoquinazoline derivatives and methods of use
Codexis, Inc.
November 23, 2017 - N°20170334886

The present invention provides kinase inhibitor analogs with improved properties, such as improved efficacy, pharmacokinetics, safety, and specificity. In some embodiments, the present invention provides lapatinib analogs that provide therapeutic benefits.
Compositions and methods for the prevention and treatment of autoimmune conditions
The General Hospital Corporation
November 23, 2017 - N°20170333540

The methods include selectively reducing or expanding t cells according to the antigenic specificity of the t cells. Therefore, the present invention can be used to reduce or eliminate pathogenic t cells that recognize autoantigens, such as beta cell specific t cells. As such, the present invention can be used to prevent, treat or ameliorate autoimmune diseases such as iddm. ...
Molecular constructs and uses thereof
The University Of Notre Dame Du Lac
November 23, 2017 - N°20170333524

Molecular constructs and dual recognition constructs having a sequence encoding a tcr affinity weakening motif, and dna and rna sequences corresponding thereto, are presented. Modified t-cells and other cells transformed with the molecular contracts express a modified tcr that imparts a reduction, in non-specific binding, an enhancement of binding specificity and an enhancement of binding affinity for a target antigen, ...
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Download 262+ patent application PDFs
Specificity Patent Applications
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For professional research & prior art discovery
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  • 262+ full patent PDF documents of Specificity-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Systems and methods for routing communications within global payment networks
Mastercard International Incorporated
November 16, 2017 - N°20170331724

Exemplary payment networks and methods are provided for facilitating data transfers. One exemplary method includes determining a subset of network routers that offer access to a regional hub based on network address summaries for first and second routers and prioritizing the first router over the second router, based on a specificity value of each of the first and second routers, ...
Systems and methods for discovery and analysis of markers
Mastercard International Incorporated
November 16, 2017 - N°20170328885

A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass spectrometry platform system to identify patterns of polypeptides in said case samples and in the control samples without regard to the specific ...
Engineered crispr-cas9 nucleases with altered pam specificity
The General Hospital Corporation
November 16, 2017 - N°20170327806

Engineered crispr-cas9 nucleases with altered and improved pam specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
The General Hospital Corporation
November 16, 2017 - N°20170327805

Methods for increasing specificity of rna-guided genome editing, e. G., editing using crispr/cas9 systems.
Igm and ige heavy chain domain 2 as covalently linked homodimerization modules for the generation of ...
UniversitÄt Stuttgart
November 16, 2017 - N°20170327594

The present invention provides a polypeptides comprising a heavy chain domain 2 (hd2) from igm or ige and at least one pharmaceutically active moiety, complexes thereof and their use for therapy and prophylaxis.
Vedolizumab for the treatment of fistulizing crohn's disease
Millennium Pharmaceuticals, Inc.
November 16, 2017 - N°20170327584

A method for treating a human patient suffering from fistulizing crohn's disease, comprising administering to a patient suffering from fistulizing crohn's disease, a humanized antibody having binding specificity for human α4β7 integrin, wherein the human patient has a seton that was surgically placed prior to administration of the antibody, and wherein the dosing regimen induces fistula(e) ...
Anti-ngf compositions and use thereof
Alderbio Holding Llc
November 16, 2017 - N°20170327568

The present invention is directed to antibodies and fragments thereof having binding specificity for ngf. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the vh, vl and cdr polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-ngf antibodies and binding fragments thereof conjugated ...
Design, synthesis, and biological evaluation of 1-methyl-1, 4-dihyrdoindeno[1,2-c]pyrazole analogues as potential anticaner agents ...
Alderbio Holding Llc
November 16, 2017 - N°20170327468

Wherein r represents nh2 or nhoh; the invention also discloses a preparation method of the indenopyrazole compound, or pharmaceutical salts thereof. The compound of the present invention is an indenopyrazole small-molecule tubulin inhibitor having a novel structure, and has very strong proliferation inhibition activity to human hepatocellular carcinoma (hepg2) cells, human prostate carcinoma (pc3) cells, human cervical carcinoma (hela) cells, ...
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