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Date/App# patent app List of recent Specificity-related patents
04/17/14
20140108310
 System and method for optimizing teams patent thumbnailnew patent System and method for optimizing teams
A system, method and program product for optimizing a team to solve a problem. The system includes: a team building system for building a fundamental analytic team from a database of analysts to solve an inputted problem, wherein the fundamental analytic team includes at least one cluster of analysts characterized with specificity and at least one cluster of analysts characterized with sensitivity; and a problem analysis system that collects sensor data from the fundamental analytic team operating within an immersive environment, wherein the problem analysis system includes a system for evaluating the sensor data to identify a bias condition from the fundamental analytic team, and includes a system for altering variables in the immersive environment in response to a detected bias condition..
04/17/14
20140106433
 Rnase h-based assays utilizing modified rna monomers patent thumbnailnew patent Rnase h-based assays utilizing modified rna monomers
The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and sequencing reactions. The novel oligonucleotides comprise a ribonucleic acid domain and a blocking group at or near the 3′ end of the oligonucleotide.
04/17/14
20140106414
 Compositions and methods for producing chemicals and derivatives thereof patent thumbnailnew patent Compositions and methods for producing chemicals and derivatives thereof
The present invention provides methods for producing a product of one or more enzymatic pathways. The pathways used in the methods of the invention involve one or more conversion steps such as, for example, an enzymatic conversion of guluronic acid into d-glucarate (step 7); an enzymatic conversion of 5-ketogluconate (5-kga) into l-iduronic acid (step 15); an enzymatic conversion of l-iduronic acid into idaric acid step 7b); and an enzymatic conversion of 5-ketocluconate into 4,6-dihydroxy 2,5-diketo hexanoate (2,5-ddh) (step 16).
04/10/14
20140099674
 Recombinase polymerase amplification patent thumbnailRecombinase polymerase amplification
This disclosure describes related novel methods for recombinase-polymerase amplification (rpa) of a target dna that exploit the properties of recombinase and related proteins, to invade double-stranded dna with single stranded homologous dna permitting sequence specific priming of dna polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes, thus offering easy and affordable implementation and portability relative to other amplification methods.
04/10/14
20140099626
 Mechanism for automating the process of individual learner course selection in a learning management system (lms) patent thumbnailMechanism for automating the process of individual learner course selection in a learning management system (lms)
Embodiments include a method, system and computer program product for automating individual learner course selection. The method includes accessing, by a computer processor, course descriptions for a plurality of variants of a course.
04/03/14
20140095128
 Method of predicting dna 3d structure based on primary dna sequence patent thumbnailMethod of predicting dna 3d structure based on primary dna sequence
Provided is a method of predicting a dna structure by predicting the distribution of a nucleosome in a dna sequence using a specificity of a nucleosome, and a method of determining a position of a nucleosome in dna sequence by predicting the position using a specificity of a nucleosome.. .
03/27/14
20140088937
 Methods of predicting the probability of modulation of transcript levels by rnai compounds patent thumbnailMethods of predicting the probability of modulation of transcript levels by rnai compounds
The present invention provides a method for determining the probability that an rnai compound modulates the expression level of a gene using a linear regression model. The present invention also provides a method for determining the probabilities that an rnai compound modulates the expression levels of each gene in a set of genes of interest using the linear regression model.
03/27/14
20140088406
 Assessment of coronary heart disease with carbon dioxide patent thumbnailAssessment of coronary heart disease with carbon dioxide
The invention provides methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising co2 to a subject to reach a predetermined paco2 in the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. The invention also provides methods for increasing sensitivity and specificity of bold mri..
03/27/14
20140088183
 Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia patent thumbnailIsolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia
The present disclosure provides compositions and methods for alleviating inflammatory-associated diseases and conditions. These methods include administering individual and/or a mixture of multiple flavans isolated from a single or multiple acacia genus of plants.
03/27/14
20140088001
 Methods for diagnosing organ specificity of glucose intolerance patent thumbnailMethods for diagnosing organ specificity of glucose intolerance
The present application pertains to a technique useful for the differentiation and diagnosis of organ specificity of hyperglycemia and glucose intolerance in type 2 diabetes, pre-diabetes or populations with risk to develop type 2 diabetes.. .
03/27/14
20140086928
Antigenic gm-csf peptides and antibodies to gm-csf
Hybridoma lines that secrete human monoclonal antibodies with high binding specificity and biological activity, particularly neutralizing activity against granulocyte-macrophage colony stimulating factor, and methods of generating the hybridoma lines are provided. Target antigens and epitopes are also provided.
03/27/14
20140086927
Novel epitope and mechanism of antigen-antibody interaction in an influenza virus
Antibodies (abs) play roles in protection against influenza. Neutralizing abs either inhibit the binding of hemagglutinin (ha) to cellular receptors or prevent the conformational change of ha induced by low ph.
03/27/14
20140086497
Method and system for optimizing accuracy-specificity trade-offs in large scale visual recognition
As visual recognition scales up to ever larger numbers of categories, maintaining high accuracy is increasingly difficult. Embodiment of the present invention include methods for optimizing accuracy-specificity trade-offs in large scale recognition where object categories form a semantic hierarchy consisting of many levels of abstraction..
03/20/14
20140081004
Glycosylated specificity exchangers
The present invention is directed to ligand/receptor and antigen/antibody specificity exchangers comprising a saccharide or glycoconjugate. Methods of making these specificity exchangers and methods of using said specificity exchangers to treat or prevent human disease are described herein..
03/20/14
20140079702
Antagonists of il-6 to raise albumin and/or lower crp
The present invention is directed to therapeutic methods using il-6 antagonists such as antibodies and fragments thereof having binding specificity for il-6 to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum c-reactive protein level or a reduced serum albumin level prior to treatment.
03/20/14
20140079682
Pon polypeptides, polynucleotides encoding same and compositions and methods utilizing same
Isolated polynucleotides and polypeptides encoded therefrom are provided. These include mutated pon enzymes with increased, modified or substantially the same substrate specificity as compared to respective wild-type pon.
03/20/14
20140079643
Protein skeletal module which increases the binding affinity and binding specificity of active polypeptides
The present invention relates to a novel protein skeletal module which increases the binding affinity or binding specificity of active polypeptides. More particularly, the present invention relates to a protein skeletal module comprising polypeptides consisting of the 1st to 19th amino acids of the amino acid sequence expressed in sequence number 1; polypeptides comprising active polypeptides; and polypeptides consisting of the 29th to 86th amino acids of the amino acid sequence expressed in sequence number 1.
03/13/14
20140073553
Amylase variants
The present invention relates to variants (mutants) of polypeptides, in particular termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, ph/activity profile, ph/stability profile, stability towards oxidation, ca2+ dependency, specific activity, and solubility, in particular under production conditions.. .
03/06/14
20140068494
Information navigation on electronic devices
In one example, a method includes outputting for display a first graphical user interface (gui) of an application executing at the portable computer terminal, wherein the first gui displays information received from the mobile computing device at a first degree of specificity. The method also includes, in response to receiving input to display a second gui of the application: outputting, for display at a presence-sensitive display device of the portable computer terminal, the second gui and removing the first gui from display.
03/06/14
20140065725
Amplified nucleic acid detection method and detection device
An object of the invention is to provide a nucleic acid detection method which takes advantage of the high specificity of hybridization techniques, reduces the time length and the number of steps required for detection of pcr products, and allows for easy and highly accurate detection by visual observation without the need of special equipment; and a nucleic acid detection device or kit. The invention provides a method for detecting a target nucleic acid in a sample, which includes performing amplification of the target nucleic acid sequence to synthesize an amplification product having a partially double-stranded structure where a single-stranded region is added to each end of the target sequence, and hybridizing a nucleic acid sequence bound to a development medium and a nucleic acid sequence labeled with a labeling compound with the single-stranded regions of the amplification product to form a sandwich hybridization complex; and a detection device thereof..
03/06/14
20140065711
Small molecule-dependent inteins and uses thereof
Elucidating the function of proteins in mammalian cells is particularly challenging due to the inherent complexity of these systems. Methods to study protein function in living cells ideally perturb the activity of only the protein of interest but otherwise maintain the natural state of the host cell or organism.
03/06/14
20140065674
Antibody molecules which bind il-17a and il-17f
The invention relates to antibody molecules having specificity for antigenic determinants of both il-17a and il-17f, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.. .
03/06/14
20140065608
Method for the enumeration of mammalian micronucleated erythrocyte populations, while distinguishing platelets and/or platelet-associated aggregates
A method for the enumeration of micronucleated erythrocyte populations while distinguishing platelet and platelet-associated aggregates involves the use of a first fluorescent labeled antibody having binding specificity for a surface marker for reticulocytes, a second fluorescent labeled antibody having binding specificity for a surface marker for platelets, and a nucleic acid staining dye that stains dna (micronuclei) in erythrocyte populations. Because the fluorescent emission spectra of the first and second fluorescent labeled antibodies do not substantially overlap with one another or with the emission spectra of the nucleic acid staining dye, upon excitation of the labels and dye it is possible to detect the fluorescent emission and light scatter produced by the erythrocyte populations and platelets, and count the number of cells from one or more erythrocyte populations in said sample.
03/06/14
20140065163
Antibody with specificity for gm-csf (ii)
The present invention relates to antibodies with specificity for granulocyte-macrophage colony stimulating factor (gm-csf). More particularly, the invention relates to humanized monoclonal antibodies that bind specifically to human gm-csf with high affinity.
02/27/14
20140058733
Screen reader with focus-based speech verbosity
The amount of speech output to a blind or low-vision user using a screen reader application is automatically adjusted based on how the user navigates to a control in a graphic user interface. Navigation by mouse presumes the user has greater knowledge of the identity of the control than navigation by tab keystroke which is more indicative of a user searching for a control.
02/27/14
20140057331
Flavin-bound glucose dehydrogenases, a method for producing a flavin-bound glucose dehydrogenase, and yeast transformant used for the same
A heat-resistant flavin-bound glucose dehydrogenase having a high substrate specificity for d-glucose, an method for producing the same, and a transformant used for the same. A flavin-bound glucose dehydrogenase gene encoding a flavin-bound glucose dehydrogenase derived from mucor is introduced into yeast, zygosaccharomyces, to obtain a transformant.
02/27/14
20140057329
Ketol-acid reductoisomerase using nadh
Methods for the evolution of nadph specific ketol-acid reductoisomerase enzymes to acquire nadh specificity are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from pseudomonas that have undergone co-factor switching to utilize nadh are described..
02/27/14
20140056855
Llp2a-bisphosphonate conjugates for osteoporosis treatment
The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. Llp2a, conjugated with a bisphosphonate drug, e.g.
02/20/14
20140050738
Anti-tace antibody molecules and their uses
Anti-tace (adam17) antibodies are disclosed that for the first time in the art are capable of binding to tace, of acting as antagonists of one or more its biological activities, in particular by binding to tace in a cross domain binding mode in which residues in both the catalytic domain and in the cysteine rich/disintegrin domains (dis-cys) are involved in antibody binding to tace, helping to improve the specificity of the antibody binding and/or helping to improve inhibition of tace biological activity. The therapeutic uses of the antibodies, in particular for the treatment of cancer are disclosed..
02/20/14
20140047906
Lc-ms configuration for purification and detection of analytes having a broad range of hydrophobicites
Systems, apparatuses, kits, and methods for purification and analysis of analytes having a broad range of hydrophobicities by liquid chromatography-mass spectrometry (lc-ms). Using one set of liquid chromatography columns, one set of mobile phase buffers, and, optionally, a single ionization method (e.g., electrospray ionization), a wide range of analytes can be purified and analyzed on a liquid chromatography-mass spectrometry (lc-ms) system.
02/13/14
20140046037
Novel immunoglobulin-binding proteins with improved specificity
The present invention relates to modified immunoglobulin-binding proteins, e.g., staphylococcus protein a, having improved binding specificity for immunoglobulins and methods of making and using the same.. .
02/13/14
20140045727
Polymer conjugate enhanced bioassays
Incorporation of modified branched polymers in one or more components of assays enhances sensitivity, specificity or both, providing powerful point of use tests.. .
02/13/14
20140045215
Neutralizing anti-ccl20 antibodies
The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human cc chemokine ligand 20 (ccl20). The present invention further relates to heavy chains and light chains of said antibodies.
02/13/14
20140045190
Method and device for monitoring real-time polymerase chain reaction (pcr) utilizing electro-active hydrolysis probe (e-tag probe)
A method for real-time electrochemical monitoring of pcr amplicons using a hydrolysis probe that is labeled with electro-active indicators and a microchip for implementing the method. The method provided is simpler and has higher specificity compared with the prior art.
02/13/14
20140045188
Primer and method for quantitative assay of microrna and application of same
A method and primer for quantitative assay of micrornas (mirnas) and application of the same are provided. In this method, mirnas are subjected to polyadenylation and subsequent reverse transcription with mirna-specific s-oligo(dt) rt primers.
02/13/14
20140044745
Influenza a virus vaccines and inhibitors
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (cpsf30) binding site on the surface of the influenza a non-structural protein 1 (ns1). Specifically, critical biochemical reagents, conditions for crystallization and nmr analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza a (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development..
02/13/14
20140044732
Nucleic acids encoding antibody molecules which bind il-17a and il-17f
The invention relates to antibody molecules having specificity for antigenic determinants of both il-17a and il-17f, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.. .
02/13/14
20140044673
Classifying skin lesions using mass spectrometry proteomic approach
The present invention provides for a mass spectrometry proteomic approach to distinguishing spitz nevi from spitzoid malignant melanoma. Histology directed mass spectral profiling allows for targeted analysis of sites of melanocytic lesion within formalin-fixed, paraffin embedded excisional biopsies.
02/13/14
20140044230
System and method for low dose tomosynthesis
A breast imaging system leverages the combined strengths of two-dimensional and three-dimensional imaging to provide a breast cancer screening with improved sensitivity, specificity and patient dosing. A tomosynthesis system supports the acquisition of three-dimensional images at a dosage lower than that used to acquire a two-dimensional image.
02/06/14
20140038185
Polynucleotide primers and probes
The present invention provides a novel technology that involves improved primer design. These primer pairs have a wide range of applications and provide high sensitivity and specificity..
02/06/14
20140037543
Anti-pancreatic cancer antibodies
Described herein are compositions and methods of use of anti-pancreatic cancer antibodies or fragments thereof, such as murine, chimeric, humanized or human pam4 antibodies. The subject antibodies show a number of novel and useful therapeutic characteristics, such as binding with high specificity to pancreatic and other cancers, but not to normal or benign pancreatic tissues and binding to a high percentage of early stage pancreatic cancers.
01/30/14
20140033370
Visual screening for enzymes on the phenylpropanoid pathway
The invention relates to a method to screen for a nucleic acid molecule encoding a polypeptide involved in the synthesis of naringenin chalcone which demonstrates altered expression, activity or substrate specificity. The invention further relates to nucleic acid molecules identified by said screen and to transgenic plants modified to express said nucleic acid molecule..
01/30/14
20140032208
Labeling context slices to produce a storyline from mobile device data
Embodiments create and label context slices from observation data that together define a storyline of a user's movements. A context is a (possibly partial) specification of what a user was doing in the dimensions of time, place, and activity.
01/30/14
20140032198
Application of multidimensional matrix for drug moleculas design and the methodologies for drug molecular design
The present invention relates to the application of multidimensional matrix for drug design and the methodology for drug design, which for the first time introduces the concept of matrix optimization in mathematics to the design of drugs and the relevant molecules. The present invention uses multidimensional matrix to analyze the permutation and combination of factors that affect the chemical structures and properties of drugs, and classifies and compares the huge amounts of factors need to be considered in the drug discovery according to certain features, thus utilizes fewer number of variables to represent the huge number of variable factors to specifically obtain chemical structures for effective drugs and improves the physicochemical properties of the compounds.
01/30/14
20140031641
Integrating device-based sensors and bedside biomarker assays to detect worsening heart failure
Devices and methods for improving the sensitivity and specificity of heart failure (hf) detection are described. The devices and methods can detect a hf status such as using physiological sensor data and external biomarker assays.
01/30/14
20140031292
Yeast cell surface display of proteins and uses thereof
The present invention provides a genetic method of tethering polypeptides to the yeast cell wall in a form accessible for binding to macromolecules. Combining this method with fluorescence-activated cell sorting provides a means of selecting proteins with increased or decreased affinity for another molecule, altered specificity, or conditional binding.
01/30/14
20140031247
Methods and compositions for gamma-secretase assay
Presented herein are polypeptide substrates based on notch polypeptides, assay methods based on the use of these substrates, and screening methods directed toward identifying inhibitors of γ-secretase activity. The assay methods and the screening methods are adapted for use in high throughput multi-well plate assay apparatuses.
01/30/14
20140031060
Creating context slices of a storyline from mobile device data
Embodiments create and label context slices from observation data that together define a storyline of a user's movements. A context is a (possibly partial) specification of what a user was doing in the dimensions of time, place, and activity.
01/30/14
20140030791
Mutant mt-sp1 proteases with altered substrate specificity or activity
Mt-sp1 mutein proteases with altered specificity for the target molecules they cleave can be used to treat human diseases, such as cancer. Cleaving vegf or vegfr at certain substrate sequences with wild-type and mutein mt-sp1 proteases can be used to treat pathologies associated with angiogenesis..
01/30/14
20140030702
Modified influenza virus for monitoring and improving vaccine efficiency
The immunogenicity of the influenza virus hemagglutinin (ha) molecule may be increased by substitutions of amino acids in the ha sequence. The substitution of specific ha residues, such as asparagine at position 223 of h5 ha, increase the sensitivity of the hemagglutinin inhibition (hi) assay by altering receptor specificity and/or antibody-antigen binding.
01/30/14
20140030253
Humanized forms of monoclonal antibodies to human gnrh receptor
Humanized forms of murine ghr106 monoclonal antibodies and methods of using them are described. Humanized ghr106 monoclonal antibodies have high affinity and specificity to the corresponding tumor-associated antigen, gonadotropin-releasing hormone (gnrh) receptor comparable to murine ghr106..
01/23/14
20140026234
Biomarkers and their uses in cancer detection and therapy
Presented herein are novel protein biomarkers related to cancers with stromal components. These newly identified biomarkers create the basis for multiple (single) assays using traditional bioassay technologies and when used in combination yield exceptional clinical sensitivity and specificity in the determination of diagnosis and/or prognosis of cancer.
01/23/14
20140024809
Hla-restricted, peptide-specific antigen binding proteins
Antigen binding proteins with tcr-like paratopes, that is, with an antigen binding region specific for an hla-a2 restricted peptide are disclosed. The antigen binding proteins encompass antibodies in a variety of forms, including full-length antibodies, substantially intact antibodies, fab fragments, f(ab′)2 fragments, and single chain fv fragments.
01/23/14
20140024601
Chimeric immunoreceptor useful in treating human cancers
The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of t lymphocytes, direct t cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific.
01/23/14
20140024083
Alpha-amylase mutants
The invention relates to a variant of a parent termamyl-like alpha-amylase, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to the parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, ph/activity profile, ph/stability profile, stability towards oxidation, ca2+ dependency and specific activity.. .
01/23/14
20140024082
Activated sugars
Kinase and nucleotidyltransferase enzymes for the production of activated sugars have been developed. These enzymes have improved stability for industrial application and relaxed specificity towards a variety of sugars.
01/23/14
20140024077
Antibody molecules having specificity for human il-6
The invention relates to antibody molecules having specificity for antigenic determinants of il-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.. .
01/23/14
20140023641
Antibody with specificity for gm-csf (i)
The present invention relates to antibodies with specificity for granulocyte-macrophage colony stimulating factor (gm-csf). More particularly, the invention relates to humanized monoclonal antibodies that bind specifically to human gm-csf with high affinity.
01/16/14
20140018545
Inhibitors of dipeptidylpeptidase iv
The present invention relates to inhibitors of post-proline cleaving enzymes, such as inhibitors of dipeptidyl peptidase iv, as well as pharmaceutical compositions thereof, and methods for using such inhibitors. In particular, the inhibitors of the present invention are improved over those in the prior art by selection of particular classes of sidechains in the p1 and/or p2 position of the inhibitor that contain a carboxylic acid moiety.
01/16/14
20140017764
Method for engineering proteases and protein kinases
Provided are methods for protein engineering, such as engineering proteases or kinases. The methods may utilize yeast display and/or er sequestration of proteins or substrates.
01/16/14
20140017686
Method for assessing risk of hepatocellular carcinoma
The present invention aims at providing a method for assessing risk of hepatocellular carcinoma with high sensitivity and specificity. Extracted were 30 regions containing 45 cpg sites which have dna methylation levels significantly different between in normal liver tissue samples and in noncancerous liver tissue samples from patients with hepatocellular carcinoma.
01/16/14
20140017167
Anti-il1rap antibodies and their use for treating human
The present invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (il1rap) for use in inducing cell death and/or inhibiting the growth and/or proliferation of cells associated with a solid tumour, wherein the cells express il1rap. A related aspect of the invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (il1rap) for use in detecting pathological cells associated with a solid tumour, wherein the cells express il1rap.
01/09/14
20140013311
Iterative bottleneck detector for executing applications
A bottleneck detector may use an iterative method to identify a bottleneck with specificity. An automated checkpoint inserter may place checkpoints in an application.
01/09/14
20140010829
Antibodies for tumor gangliosides
High affinity antibodies were made to gangliosides expressed on tumor cells. The antibodies can be used analytically, diagnostically, therapeutically, and theranostically.
01/02/14
20140007265
Chimeric gene constructs for generation of fluorescent transgenic ornamental fish
Four zebrafish gene promoters, which are skin specific, muscle specific, skeletal muscle specific and ubiquitously expressed respectively, were isolated and ligated to the 5′ end of the egfp gene. When the resulting chimeric gene constructs were introduced into zebrafish, the transgenic zebrafish emit green fluorescence under a blue light or ultraviolet light according to the specificity of the promoters used.
01/02/14
20140005369
Uridine-based gadolinium complex and mri contrast agent including the same
The present invention relates to a new uridine nucleoside-based amphiphilic gadolinium complex and a magnetic resonance imaging (mri) contrast agent including the gadolinium complex. The mri contrast agent has high relaxivity, high binding affinity for and stability in human serum albumin, ph response, and high liver specificity..
01/02/14
20140005125
Designed ankyrin repeat proteins binding to platelet-derived growth factor
New designed ankyrin repeat proteins with binding specificity for pdgf-bb are described, as well as nucleic acids encoding such pdgf binding proteins, pharmaceutical compositions comprising such proteins and the use of such proteins in the treatment of diseases.. .
01/02/14
20140005069
Glycoprofiling with multiplexed suspension arrays
The present invention is includes compositions and methods directed to the multiplexed analysis of carbohydrates and carbohydrate containing compounds. The compositions and methods utilize suspension array technology (sat) and an array of different carbohydrate binding molecules, each carbohydrate binding molecules with a known carbohydrate binding specificity, to obtain a glycoprofile of the carbohydrate structure(s) in a sample.
01/02/14
20140004618
System and method for chemical and/or biological detection
A method and system for detecting the presence of chemical and/or biological agents are disclosed. An additive, which may comprise a reactant and/or a catalyst selected for its capacity to react with, or to force a reaction involving a target chemical and/or biological agent, may be introduced into a sample of an ambient environment to be monitored.
01/02/14
20140004123
Monoclonal antibody production by ebv transformation of b cells
A method for producing a clone of an immortalised human b memory lymphocyte, comprising the step of transforming human b memory lymphocytes using epstein barr virus (ebv) in the presence of a polyclonal b cell activator. The method is particularly useful in a method for producing a clone of an immortalised human b memory lymphocyte capable of producing a human monoclonal antibody with a desired antigen specificity, comprising the steps of: (i) selecting and isolating a human memory b lymphocyte subpopulation; (ii) transforming the subpopulation with epstein ban virus (ebv) in the presence of a polyclonal b cell activator; (iii) screening the culture supernatant for antigen specificity; and (iv) isolating an immortalised human b memory lymphocyte clone capable of producing a human monoclonal antibody having the desired antigen specificity..
01/02/14
20140004116
Methods of preventing or treating pain using anti-ngf antibodies
Antibodies and antibody fragments thereof with binding specificity to human nerve growth factor (ngf) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human ngf antibody or antibody fragment thereof, which inhibits the association of ngf with trka, and/or p75.
01/02/14
20140004115
Methods of preventing or treating pain using anti-ngf antibodies that selectively inhibit the association of ngf with trka, without affecting the association of ngf with p75
This invention pertains to ngf antagonists including antibodies and antibody fragments thereof having binding specificity to human nerve growth factor (“ngf”), and methods of treating pain. Methods of treating pain or eliciting an analgesic effect in an individual comprising administering an effective amount of an ngf antagonist inhibits the association of ngf with trka without inhibiting the association of ngf with p75.


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Specificity topics: Specificity, Antibodies, Cancer Cell, Cancer Cells, Recombinant, Monoclonal Antibody, Monoclonal, Therapeutics, Immune Response, Immunostimulator, Stimulator, Compatibility, Histocompatibility, Major Histocompatibility Complex, Immunotherapy

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