|| List of recent Solubility-related patents
|Method for preparing high purity mono-hydrolyzed acyl halide compound|
A method for preparing a high purity (e.g. Greater than 70 wt.
|A compound for inhibiting 11b-hydroxy steroid dehydrogenase 1, and a pharmaceutical composition comprising the same|
Disclosed are a novel compound or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition including the same for inhibiting human 11-β-hydroxy steroid dehydrogenase type 1 (11β-hsd1). The disclosed compound and the pharmaceutical composition including the same for inhibiting human 11-β-hydroxy steroid dehydrogenase type 1 (11β-hsd1) are excellent in activity and solubility, and is more efficient in formulation and transfer..
There is provided a fluorescent dye which can improve the fluorescent intensity at the time of labeling to thereby detect a biomolecule with higher sensitivity. The fluorescent dye of the present invention includes a nitrogen cation-containing group or a nitrogen-containing group.
|Use of inorganic matrix and organic polymer combinations for preparing stable amorphous dispersions|
The present invention relates to methods for processing pharmaceutically active substances having poor water solubility in the presence of an inorganic matrix, e.g., magnesium aluminometasilicate, and a secondary polymer as a means of converting the crystalline api to substantially amorphous and stable form, i.e., the crystallinity is less than 5%. The methods of the invention result in more complete amorphization, increased solubility, drug loading and stability as compared to typical amorphization or literature methods..
|Crystals of salts of phenylalanine derivatives|
Provided is a crystal of a salt of the compound represented by formula (i), which is excellent in its solubility in water. In particular, also provided is a crystal of hydrochloride, hydrobromate, sulfate, nitrate, p-toluenesulfonate or methanesulfonate of the compound represented by formula (i)..
|Oral formulations of kinase inhibitors|
The invention is directed to formulations of bioactive compounds of limited water solubility, inhibitors of focal adhesion kinase (fak) of the 2,4-diaminopyridine class, adapted for oral administration to patients. The formulations are self-emulsifying in the gastrointestinal tract of the patients, providing enhanced absorption and bioavailability of the bioactive compounds as dispersions or emulsions in an oil base.
|Method for fabricating an interlayer|
The present invention relates to a method for fabricating an interlayer, and particularly relates to a method for fabricating an interlayer pcbm which is difficult to be dissolved in organic solvents. The solubility of the interlayer (pcbm) in organic solvents is decreased by polymerization of the interlayer (pcbm).
|Binder composition for secondary battery negative electrode, negative electrode for secondary battery, negative electrode slurry composition, manufacturing method, and secondary battery|
A binder composition for a negative electrode of a secondary battery, including a particulate binder, and a water-soluble polymer containing an acidic functional group, wherein the water-soluble polymer has an ion conductivity of 1×10−5 to 1×10−3 s/cm; and a swelling degree of the water-soluble polymer to a liquid with a solubility parameter of 8 to 13 (cal/cm3)1/2 is 1.0 to 2.0 times a swelling degree of the particulate binder measured under the same conditions; and use thereof.. .
|Passivation of metal halide scintillators|
A halide material, such as scintillator crystals of labr3:ce and sri2:eu, with a passivation surface layer is disclosed. The surface layer comprises one or more halides of lower water solubility than the scintillator crystal that the surface layer covers.
|Polymerizable compound, polymerizable composition, polymer, and optically anisotropic body|
The present invention provides a polymerizable compound represented by the following formula (i), a polymerizable composition that includes the polymerizable compound and an initiator, a polymer obtained by polymerizing the polymerizable compound or the polymerizable composition, and an optically anisotropic article that includes the polymer. The invention makes it possible to provide a polymerizable compound, a polymerizable composition, and a polymer that have a practical low melting point, exhibit an excellent solubility in a general-purpose solvent, can be produced at low cost, and may produce an optical film that achieves uniform conversion of polarized light over a wide wavelength band, and an optically anisotropic article.
|Monofunctional branched polyethylene glycol and modified bio-related substance thereof|
The monofunctional branched poly(ethylene glycol) (peg) has a general formula shown in formula (1), and the bio-related substance modified by the monofunctional branched peg has a general fomula shown in formula (2), wherein x1 and x2 are each independently a hydrocarbon group having 1 to 20 carbon atoms, n1 and n2 are each independently an integer selected from 1 to 1000, n3 is an integer selected from 11 to 1000, l1, l2 are each independently a linking group, p is 0 or 1, q is 0 or 1, r1 is a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms, d is a bio-related substance, z is a linking group, and z can react with the bio-related substance to form a residue group l3. The peg-modified bio-related substance maintains good biological activity, and has better solubility and a longer half-life in vivo..
|Patterning process, resist composition, polymer, and monomer|
A negative pattern is formed by applying a resist composition onto a substrate, prebaking, exposing to high-energy radiation, peb, and developing the exposed resist film in an organic solvent developer to dissolve the unexposed region of resist film. The resist composition comprising a polymer adapted to form a lactone ring under the action of an acid so that the polymer may reduce its solubility in an organic solvent displays a high dissolution contrast.
|Pattern-forming method, electron beam-sensitive or extreme ultraviolet radiation-sensitive resin composition, resist film, manufacturing method of electronic device using them and electronic device|
A pattern-forming method includes in this order: step (1) of forming a film with an electron beam-sensitive or extreme ultraviolet radiation-sensitive resin composition that contains (a) a resin having an acid-decomposable repeating unit and capable of decreasing a solubility of the resin (a) in a developer containing an organic solvent by an action of an acid and (b) a low molecular weight compound capable of generating an acid upon irradiation with an electron beam or extreme ultraviolet radiation and decomposing by an action of an acid to decrease a solubility of the low molecular weight compound (b) in an organic solvent; step (2) of exposing the film with an electron beam or extreme ultraviolet radiation; and step (4) of developing the film with a developer containing an organic solvent after the exposing to form a negative pattern.. .
|Redox flow batteries based on supporting solutions containing chloride|
Redox flow battery systems having a supporting solution that contains cl− ions can exhibit improved performance and characteristics. Furthermore, a supporting solution having mixed so42− and cl− ions can provide increased energy density and improved stability and solubility of one or more of the ionic species in the catholyte and/or anolyte.
|Method for producing a soluble cocoa product from cocoa powder|
The present invention relates to a method for producing a soluble cocoa product from cocoa powder. The present invention further relates to cocoa products obtained by the present method and uses thereof.
|Method for improving viscosity, solubility, and particle size of milk protein concentrates|
Disclosed is a method for decreasing viscosity, increasing solubility and decreasing particle size of milk proteins by admixing milk protein with at least one transglutaminase.. .
|Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compound|
The subject invention relates to novel soluble forms of planar ring structured organic compounds including flavonoids, and their production. The invention also includes the use of these novel formulations of planar ring structured organic compounds in the preparation of formulations and products.
|Magenta dyes and their preparation methods and applications|
The present invention relates to a class of magenta dyes, their preparation methods and applications. The magenta dyes include the compounds which simultaneously contain carboxyl group, sulfonic acid group and the carbonyl propyl sulfurylsulfonic acid on the anthrapyridone skeleton, showing in the form of general formula (i) or their mixtures.
|Filter media including glass fibers|
The present disclosure generally relates to filter media including glass fibers. The fiber characteristics (e.g., composition, dimensions) are selected to impart the desired solubility, filtration and mechanical properties so that the filter media may be used in the desired application..
|Bulk polymerization of (meth)acrylate copolymers soluble under aqueous-alkaline conditions|
The invention relates to the synthesis of (meth)acrylate-based mass polymers which are soluble in aqueous alkaline. The invention in particular relates to the synthesis of polymers by means of a mass polymerization.
|Novel inhibitor compositions and methods of use|
The invention concerns a formulation and method which allow for the efficient delivery of antipolymerants of low solubility into processes for the production of ethylenically unsaturated monomers, and associated process streams, and which avoid the potential health and safety problems and economic disadvantages which are associated with the methods of the prior art and facilitate the safe and efficient production of these monomers. Specifically, the invention provides an antipolymerant composition for the prevention of unwanted polymerisation reactions during the production and processing of ethylenically unsaturated compounds, the composition comprising a concentrated liquid formulation, wherein said concentrated liquid formulation is a suspension concentrate which comprises: (a) at least one compound selected from the group comprising phenols, quinones, thiazines, hydroxylamines and aromatic amines; (b) at least one dispersing agent; and (c) at least one polar or non-polar liquid carrier.
The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation..
|Pattern-forming method, electron beam-sensitive or extreme ultraviolet radiation-sensitive resin composition, resist film, manufacturing method of electronic device using them and electronic device|
A pattern-forming method includes in this order: step (1) of forming a film with an electron beam-sensitive or extreme ultraviolet radiation-sensitive resin composition that contains (a) a resin having an acid-decomposable repeating unit and capable of decreasing a solubility of the resin (a) in a developer containing an organic solvent by an action of an acid, (b) a compound capable of generating an acid upon irradiation with an electron beam or extreme ultraviolet radiation and (c) a solvent; step (2) of exposing the film with an electron beam or extreme ultraviolet radiation; and step (4) of forming a negative pattern by development of the film with a developer containing an organic solvent after the exposing of the film, wherein a content of the compound (b) is 21% by mass to 70% by mass on the basis of all solids content of the composition.. .
|Taste-masked pharmaceutical compositions containing diclofenac|
A pharmaceutical composition is described which includes diclofenac as an active ingredient. The pharmaceutical composition further includes a (meth)acrylic polymer which has a specific solubility and/or a particular functional group in one polymer component..
|Hydrophilic self-immolative linkers and conjugates thereof|
The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker..
|Stable and soluble antibodies inhibiting tnf alpha|
The present invention relates to particularly stable and soluble scfv antibodies and fab fragments specific for tnf, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of tnf, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of tnf-mediated disorders.
|Methods for fabricating three-dimensional nano-scale structures and devices|
A method of fabricating a 3 dimensional structure, includes: forming a stack of at least 2 layers of photo resist material having different photo resist sensitivities upon a substrate; exposing the stack to beams of electromagnetic radiation or charged particles of different dosages to achieve selective solubility along a height of the stack; and dissolving soluble portions of the stack with a solvent to produce a 3 dimensional structure of desired geometry.. .
|Dye dispersion liquid, photosensitive resin composition for color filters, color filter, liquid crystal display device and organic light emitting display device|
An object is to provide a photosensitive resin composition for color filters, configured to be able to form a high-luminance color layer with excellent heat resistance and light resistance. Disclosed is a photosensitive resin composition for color filters including the dye dispersion liquid, the dye dispersion liquid including a dye dispersed by a dispersant in a solvent, wherein the dye is a dye having a sulfonic acid group; the dispersant is a graft copolymer having an amine number of 30 mg koh/g or more and including copolymerizable components that contain a specific monomer having a tertiary amine and a specific polymerizable oligomer; the solvent is a solvent having a solubility of the dye of 0.2 g/100 g solvent or less at 23° c.; and the tertiary amine of the dispersant and the sulfonic acid group of the dye form a micelle..
|Condensed polycyclic aromatic compound, aromatic polymer, and method for synthesizing aromatic compound|
Provided is a condensed polycyclic aromatic compound that can be used as a precursor for synthesizing a condensed polycyclic aromatic compound having relatively high solubility. Also provided is a method for synthesizing and using such a novel condensed polycyclic aromatic compound.
|Novel whitening agents for cellulosic substrates|
This invention relates to novel whitening agents for cellulosic substrates. The whitening agents are comprised of at least two components: at least one chromophore component and at least one polymeric component.
|Producing nanostructure of polymeric core-shell to intelligent control solubility of hidrophilic polymer during polymer flooding process|
Hydrophilic polymer particles have been obtained using polyacrylamide, xanthane, maleic anhydride polymers, allylamine, ethyleneimine, and oxazoline as core polymers. Then, hydrophobic polymers shells have been produced on the core-side using styrene, styrene copolymers, polyvinyl state, polysolfune, polymethyl methacrylate, and polycyclohxyl methacrylate by in-situ polymerization of monomer as method one and inverse emulsion process as method two.
|Phenolic resin and material for forming underlayer film for lithography|
There is provided a novel phenolic resin which can be used as a coating agent or a resist resin for a semiconductor, which has a high carbon concentration and a low oxygen concentration in the resin, which has a relatively high heat resistance and also a relatively high solvent solubility, and which can be applied to a wet process. There are also provided a material useful for forming a novel photoresist underlayer film which has a relatively high solvent solubility, which can be applied to a wet process, and which is excellent in etching resistance as an underlayer film for a multilayer resist, an underlayer film formed using the same, and a pattern forming method using the same.
|Resist composition, method for forming resist pattern, and high-molecular weight compound|
A resist composition having excellent lithography properties, which generates an acid upon exposure and exhibits changed solubility in a developing solution by the action of an acid, the resist composition containing a base material component (a) which exhibits changed solubility in a developing solution by the action of an acid, and the base material component (a) containing a high-molecular weight compound (a1) having a constituent unit (a0) derived from a compound represented by the following general formula (a0-1); a method for forming a resist pattern using the resist composition; and a high-molecular weight compound (a1) having a constituent unit (a0) derived from a compound represented by the following general formula (a0-1), are disclosed.. .
|Organic compound, optical film and method of production thereof|
An organic compound has the general structural formula i. In the formula i, core is a conjugated organic unit capable of forming a rod-like macromolecule, n is a number of the conjugated organic units in the rod-like macromolecule, gk is a set of ionogenic side-groups, and k is a number of the side-groups in the set gk.
|Film member and liquid ejecting apparatus|
A film member includes an inside film layer which is disposed on a surface in contact with liquid; an outside film layer which is disposed on the opposite side to the surface of the inside film layer in contact with the liquid; and a junction layer which is disposed between the inside film layer and the outside film layer to join the inside film layer and the outside film layer, in which an sp value (here, the sp value represents a solubility parameter value) of a resin material which forms the junction layer is equal to or larger than an sp value of a resin material that forms the inside film layer, and an sp value of a resin material that forms the outside film layer is equal to or larger than the sp value of the resin material that forms the inside film layer.. .
|Liquid crystal composition, antioxidant and liquid crystal display device|
A liquid crystal composition including an antioxidant, and a liquid crystal display device containing this composition are described. The liquid crystal composition has a nematic phase, has a high solubility in a liquid crystal composition, and includes a specific antioxidant useful for preventing deterioration of the composition.
|Organic-inorganic complex, and composition for forming same (as amended)|
The organic-inorganic complex of the present invention is made using an organic-inorganic complex-forming composition containing the following components a) to c): a) at least one organic silicon compound represented by the formula (i) rnsix4-n and in which a molar ratio of an organic silicon compound in which a solubility parameter of r (sp1) obtained by a fedors' estimation method is smaller than a solubility parameter of an electromagnetic ray-curable compound (sp2) obtained by the fedors' estimation method and a difference between the sp1 and the sp2 is 2.0 or more (si1) to an organic silicon compound in which sp1 is smaller than sp2 and a difference between the sp1 and the sp2 is less than 2.0 or an organic silicon compound in which sp1 is larger than sp2 (si2) (si1:si2) is within the range of 8:2 to 10:0, and/or a condensate of the organic silicon compound; b) an electromagnetic ray-curable compound; and c) metal compound particles.. .
|Composition comprising pyrazino-triazine derivatives|
Disclosed is a composition including a pyrazino-triazine derivative and a pharmaceutically acceptable salt thereof. The composition includes a solubilizer or a stabilizer and thus can exhibit very excellent solubility and stability..
|Resist composition, method of forming resist pattern and compound|
A resist composition which generates acid upon exposure and exhibits changed solubility in a developing solution under action of acid, including a base component (a) which exhibits changed solubility in a developing solution under action of acid, and a photo-decomposable quencher (d0) containing a compound represented by general formula (d0) shown below. In the formula, r1 represents a hydrocarbon group of 4 to 20 carbon atoms which may have a substituent; y1 represents a single bond or a divalent linking group; r2 and r3 each independently represents a substituent of 0 to 20 carbon atoms other than a fluorine atom; one of r2 and r3 may form a ring with y1; mm+ represents an organic cation having a valency of m; and m represents an integer of 1 or more..
|Resist composition, patterning process and polymer|
An additive polymer comprising recurring styrene units having an ester group bonded to a cf3—c(or2)—r3 group (wherein r2 is h, acyl or acid labile group, r3 is h, ch3 or cf3) such as 1,1,1,3,3,3-hexafluoro-2-propanol is added to a polymer capable of increasing alkali solubility under the action of acid to formulate a resist composition. The resist composition can minimize outgassing from a resist film during the euv lithography and form a resist film having a hydrophilic surface sufficient to prevent formation of blob defects on the film after development..
|Resist composition and patterning process|
An additive polymer comprising recurring units derived from a fluorosulfonamide-substituted styrene and recurring units derived from a stilbene, styrylnaphthalene, dinaphthylethylene, acenaphthylene, indene, benzofuran, or benzothiophene derivative is added to a polymer capable of increasing alkali solubility under the action of acid to formulate a resist composition. The resist composition can minimize outgassing from a resist film during the euv lithography and form a resist film having a hydrophilic surface sufficient to prevent formation of blob defects on the film after development..
Methods of making polyglycerol based uv-filters, topical compositions comprising such polyglycerol based uv-filters and the use of such novel polyglycerol based uv-filters to enhance the solubility of butyl methoxydibenzoylmethane or bis-ethylhexyloxyphenol methoxyphenyl triazine in cosmetic oils are provided.. .
|Compositions and/or articles with improved solubility of a solid active|
Wherein r′ and r″ are independently selected from a straight or branched c1-30 chain which may be saturated or unsaturated and z1-z6 are independently selected from hydrogen, hydroxyl, amino, amido, r′, or r″. Methods of making the aforementioned personal care compositions are also disclosed..
|Stable and soluble antibodies inhibiting tnf alpha|
The present invention relates to particularly stable and soluble scfv antibodies and fab fragments specific for tnfα, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of tnfα, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of tnfα-related disorders.
|Compositions and methods for improving rebaudioside x solubility|
Polymorphic and amorphous forms of rebaudioside x and methods for preparing the same are provided herein. Also provided herein are rebaudioside x complexes and methods for preparing the same.
|Melatonin treatment methods|
A method of treating a human subject in need of melatonin therapy comprises administering to a human subject a composition comprising melatonin dispersed in a polymer matrix adapted to cover the melatonin in a melatonin solubility enhancing ph environment after ingestion and to maintain the melatonin solubility enhancing ph environment when said composition is present in said subject's intestines so that an effective amount of melatonin is released into the subject's intestines.. .
|Pharmaceutical compositions with enhanced performance|
Pharmaceutical compositions of a low-solubility drug and lower alkanoate-, phthalate- and trimellitate esters of hydroxypropyl methyl cellulose and lower alkanoate- and succinate esters of cellulose and methyl cellulose are disclosed that provide enhanced concentrations of the drug in a use environment.. .
A composition including an ionic liquid alkylammonium salt (e.g., tetraalkylammonium cation and bis(2-ethylhexyl)phosphate anion), or an ionic liquid imidazolium salt (e.g., 1,3-dialkylimidazolium cation and bis(2-ethylhexyl)phosphate anion), that have a structure sufficient to exhibit at least partial solubility in one or more group i-v base stocks. The disclosure also relates to a lubricating oil base stock and lubricating oil containing the composition, a multifunctional functional fluid containing the composition, and a method for improving solubility of an ionic liquid in a lubricating oil by using as the lubricating oil a formulated oil including a lubricating oil base stock as a major component, and an ionic liquid alkylammonium salt cobase stock, or an ionic liquid imidazolium salt cobase stock, as a minor component..
|Vinyl ether group-containing copolymer, preparation process and use thereof|
The invention provides a vinyl ether group-containing copolymer, preparation process and use thereof. The copolymer comprises of the structural units represented by the following general formulae i, ii and iii, wherein, r1 is o or hn, r2 is an alkyl group with a carbon atom number of 1-4, cyclohexyl or a group represented by the following general formula iv (m represents a positive integer of 1-3), n is a positive integer of 1-4, the molar numbers of the structural units represented by the general formulae i, h and iii are x, y and z, respectively, and x:y:z=3-8:1-4:1-5, the weight average molecular weight of the copolymer is 5000-20000.
|Liquid crystal composition and liquid crystal display device including the same|
A liquid crystal display device may include a liquid crystal and a coloring material including at least one of yellow, magenta, and cyan coloring materials. The coloring material may have high solubility and dispersion stability on the liquid crystal, and thus, it can be used for a liquid crystal layer.
|Soluble pouch comprising hueing dye|
The present application also relates to a water soluble pouch comprising at least one compartment, the pouch comprising a water soluble film encapsulating a composition, said composition comprising a negatively charged hueing dye and a solvent system comprising a primary solvent having a hansen solubility (δ) of less than 29.. .
|Process for improved protein expression by strain engineering|
This invention is a process for improving the production levels of recombinant proteins or peptides or improving the level of active recombinant proteins or peptides expressed in host cells. The invention is a process of comparing two genetic profiles of a cell that expresses a recombinant protein and modifying the cell to change the expression of a gene product that is upregulated in response to the recombinant protein expression.
|Acrylate compound having photoreactive group, photoreactive acrylate polymer and photo-alignment layer comprising the same|
Disclosed therein are an acrylate compound having a photoreactive group, a photoreactive acrylate polymer, and a photo-alignment layer comprising the same that not only have excellences in alignment properties and alignment rate and readiness for change in the alignment direction based on the polarization direction of radiation but also exhibit a high solubility to organic solvents and good workability.. .
|Transdermal formulation containing cox inhibitors|
Disclosed are gel compositions suitable for the topical administration of an active compound having poor solubility and skin penetration, for example, of a cox-2 inhibitor compounds, processes of preparation thereof and methods of use thereof for the treatment of indications treatable by the active compound.. .
|Liposome-containing preparation utilizing dissolution aid, and method for producing same|
The present invention may include a production process for a preparation containing univesicular liposomes that encapsulate a highly water-soluble drug (d) having a water solubility of higher than 10 mg/ml and have a volume-average particle diameter of 50 to 200 nm utilizing a two-step emulsification method, to enhance an encapsulation ratio of the highly water-soluble drug in the liposomes produced, as compared with the conventional one. In a primary emulsification step of the two-step emulsification method, a w1/o emulsion may be prepared by the use of an aqueous phase liquid (w1) in which the highly water-soluble drug (d) and a solubilizing aid (s) having log d of not more than −1 at ph 7.4 are dissolved in an aqueous solvent (w1)..
|Inclusion compounds of fumagillol derivative or its salt, and pharmaceutical compositions comprising the same|
The present invention relates to an inclusion compound of fumagillol derivative or its salt with hydroxypropyl-β-cyclodextrin or sulfobutylether-7-β-cyclodextrin, and pharmaceutical compositions comprising the same. The inclusion compound according to the present invention has superior water solubility and stability while exhibiting low toxicity, rendering it valuable as an anticancer agent or inhibitor of tumor metastasis..
|Water-soluble camptothecin derivative, pharmaceutical composition and use thereof|
The present invention relates to a water soluble derivative of camptothecin and preparation method thereof, the derivative having a structure of formula i and being appropriate in water solubility, and having anti-cancer activity and stability of lactonic ring. The present invention also relates to a method for synthesizing the compound and medical use of the compound..
|Monolayer film and hydrophilic material comprising the same|
The invention provides monolayer films which not only have hydrophilicity and are excellent in such properties as antifogging properties, antifouling properties, antistatic properties and anti-condensation properties but also tend to exhibit excellent transparency even with a large film thickness and excellent scratch resistance, as well as stacks having the monolayer film. The monolayer film is obtained by preparing a mixture including a monomer composition and a solvent, the monomer composition including a specific monomer and a polyvalent monomer having two or more (meth)acryloyl groups and being free of sulfonic group, carboxyl group and phosphoric group in a specific molar ratio, the solvent having a specific solubility parameter σ; applying the mixture onto a substrate and removing at least part of the solvent; and polymerizing the monomer composition to produce a monolayer film having at least one anionic hydrophilic group selected from a sulfonic group, a carboxyl group and a phosphoric group and a specific anion concentration ratio (sa/da) of the anion concentration (sa) at the outer surface to the anion concentration (da) at the middle point between the inner surface in contact with the substrate and the outer surface..
|Crystalline 4′-epidaunorubicin hydrochloride and use thereof|
4′-epidaunorubicin hydrochloride is provided in a crystalline form which is stable and readily soluble. A process of producing the crystalline form includes crystallizing 4′-epidaunorubicin hydrochloride in a solvent system including (a) solvent a selected from c1 and c2 halogenated solvents and mixtures thereof, (b) solvent b selected from c1-c5 straight and branched alcohols and mixtures thereof, and (c) solvent c selected from c1-c5 straight and branched alcohols and mixtures thereof, wherein solvent c is selected to provide lower solubility to 4′-epidaunorubicin hydrochloride than solvent b.
|Methods for fabricating bulk heterojunctions using solution processing techniques|
Solvent mixtures useful for processing bulk heterojunction materials and methods for selecting the same are disclosed, wherein hansen solubility parameters are utilized to select the solvent mixture. A solvent system using a fully nonhalogenated solvent mixture is disclosed.
|Method of forming resist pattern|
A method of forming a resist pattern using a resist composition containing a base component (a) which exhibits reduced solubility in an organic solvent under action of an acid and an acid-generator component (b) which generates an acid upon exposure, the base component (a) including a resin component (a1) having a structural unit (a0) derived from a compound represented by general formula (a0-1) shown below and a structural unit (a2) containing a lactone-containing cyclic group or the like (in formula (a0-1), ra1 represents a monovalent substituent having a polymerizable group, la1 represents o, s or a methylene group, r1 represents a linear or branched hydrocarbon group of 2 to 20 carbon atoms which may have a substituent, or a cyclic hydrocarbon group which may have a hetero atom, and n represents an integer of 0 to 5).. .
|Resist composition and method of forming resist pattern|
A resist composition which generates acid upon exposure and exhibits changed solubility in a developing solution under the action of acid, the resist composition including: a base component (a) which exhibits changed solubility in a developing solution under the action of acid and an acid generator component (b) which generates an acid upon exposure, the base component (a) including a polymeric compound (a1) having a structural unit (a0) containing an acid decomposable group that exhibits increased polarity by the action of acid and a lactone-containing cyclic group, an —so2— containing cyclic group or a carbonate-containing cyclic group, and the acid generator component (b) including an acid generator (b1) containing a compound having a nitrogen atom exhibiting a proton acceptor property and an acid generating site capable of generating an acid upon exposure in the same molecule thereof.. .
|Resist composition and method for forming resist pattern|
A resist composition which generates an acid upon exposure and exhibits changed solubility in a developing solution by the action of an acid, the resist composition containing a base material component which exhibits changed solubility in a developing solution by the action of an acid; and the base material component containing a resin component having a constituent unit derived from a compound represented by the following general formula (a0-1), at least two or more kinds of a constituent unit containing an acid dissociable group represented by the following general formula (a1-r-1) or (a1-r-2), and a constituent unit containing a lactone-containing, an —so2-containing, or a carbonate-containing cyclic group; and a method for forming a resist pattern using the resist composition.. .
|Resist composition and method for forming resist pattern|
A resist composition which generates an acid upon exposure and exhibits changed solubility in a developing solution by the action of an acid, the resist composition containing a base material component which exhibits changed solubility in a developing solution by the action of an acid, the base material component containing a high-molecular weight compound having a constituent unit derived from a compound represented by the following formula (a0-1), a constituent unit containing a lactone-containing, a so2—-containing or a carbonate-containing cyclic group, and a constituent unit containing an acid decomposable group whose polarity increases by the action of an acid, and the high-molecular weight compound having a weight average molecular weight of not more than 6,000, and a method for forming a resist pattern using the same.. .
|Bearing components and processes for depositing additives, especially fluoropolymers, on cellulose|
A method for applying an additive, e.g. A fluoropolymer, to cellulose.
|Pharmaceutical composition comprising deferasirox|
The present invention relates to a pharmaceutical composition comprising deferasirox, a process for preparing such pharmaceutical composition, and its use in the treatment of chronic iron overload. The pharmaceutical composition comprises nanosized deferasirox having improved surface area and solubility.
|Methods of using water-soluble inorganic compounds for implants|
A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow..
|Polymerizable compound, polymerizable composition, polymer, and optically anisotropic body|
The present invention relates to a polymerizable compound represented by a formula (i). The present invention provides a polymerizable compound, a polymerizable composition, a polymer, and an optically anisotropic article that are capable of obtaining an optical film having a low melting point, having excellent solubility, capable of being manufactured at low cost, and capable of uniform polarized light conversion across a broad wavelength region.
|Surfactant comprising fluorine-containing polymer|
Provided is a surfactant which has a high surface tension reducing ability and a high solubility in a liquid medium, comprising a fluorine-containing copolymer containing, as essential components, a monomer having a fluoroalkyl group having 1 to 7 carbon atoms, a hydrophilic monomer, and a monomer having an ion donor group. Further provided are a coating composition, an ink composition and a photographic emulsion composition, each comprising the surfactant..
|Platinum compounds for treating cell proliferative diseases, preparation method and use thereof|
Disclosed are a class of platinum compounds with a leaving group of malonic acid derivatives containing amino and alkylamino, their pharmaceutically acceptable salts, their preparation methods and pharmaceutical composites comprising them. Disclosed also are for the uses of the compounds in the treatment of cell proliferative diseases, particularly for the treatment of cancers.
|Advantageous salts of mu-opiate receptor peptides|
The subject invention provides advantageous new salts of mu-opiate receptor peptides. These salts have been found to have excellent properties in terms of their crystal structure, stability, solubility, lack of impurities and/or the ability to be produced, with these advantageous properties, in amounts sufficient for the production of therapeutic compositions..
|Novel wnt compositions and therapeutic uses of such compositions|
The invention provides novel wnt polypeptides that have enhanced solubility and improved biologic drug-like properties, and polynucleotides encoding the wnt polypeptides of the invention. The wnt polypeptides of the invention can be used therapeutically, such as, for example, in methods of preventing or treating muscle loss and/or promoting muscle hypertrophy and growth..