Sleep Disorders

Sleep Disorders-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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2-oxa-5-azabicyclo[2.2.1]heptan-3-yl derivatives
Hoffmann-la Roche Inc.
May 18, 2017 - N°20170137435

The present invention relates to compounds of formula of formula i wherein x, l and r1 are as described herein, compositions containing compounds of formula i, methods of manufacture of compounds of formula i and methods of treating psychiatric, metabolic, cardiovascular or sleep disorders with compounds of formula i.
Combination airflow, sound and pulse wave sensor pack with smartphone data aquisition and transfer
Dymedix Corporation
March 23, 2017 - N°20170079580

The system of the present invention is intended to provide a simple, out-of-clinic sleep disorders testing tool. It can be used for pretest screening and diagnosis, and post therapy follow-up of patients. The hardware component comprises a disposable sensor pack containing a pvdf airflow sensor and a pvdf pulse wave sensor, each of which is permanently connected to a signal ...
Fast dissolving granulate
Boehringer Ingelheim International Gmbh
March 16, 2017 - N°20170072001

The invention relates to a fast dissolving granulate obtainable by spray-dying of a composition comprising a dry methanolic or ethanolic extract of valerian root, a dry methanolic extract of hop strobiles, optionally a carrier, one or more artificial sweeteners, one or more flavoring agents, optionally an acidifier and water for the treatment of sleep disorders, wherein the said granulate is ...
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Imidazolidinedione derivatives
Autifony Therapeutics Limited
March 09, 2017 - N°20170065585

The invention provides a compound of formula (ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of kv3. 1 and/or kv3. 2, and in the treatment of diseases or disorders where a modulator of kv3. 1 and/or kv3. 2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, ...
Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep ...
Procom One, Inc.
March 09, 2017 - N°20170065551

The invention relates to use of the trans-(e) isomer or isomeric mixtures containing specified ratios of the trans-(e) and cis-(z) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders
Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof
Paratek Pharmaceuticals, Inc.
March 09, 2017 - N°20170065517

The present invention provides novel compositions for the delivery of a hypnotic agent across the oral mucosa. In particular, the buffer system in the compositions of the present invention raises the ph of saliva to a ph greater than about 7. 8, thereby facilitating the substantially complete conversion of the hypnotic agent from its ionized to its un-ionized form. As a result, ...
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Process for the preparation of histamine h3 receptor modulators
Janssen Pharmaceutica Nv
March 02, 2017 - N°20170057919

The present invention is directed to novel processes for the preparation of histamine h3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.
Preparation for improving the action of receptors
N.v. Nutricia
February 16, 2017 - N°20170042852

The present invention relates to the use of polyunsaturated fatty acids and one or more components which have a beneficial effect on total methionine metabolism selected from the group consisting of vitamin b 12 and precursors thereof, vitamin b6 and derivatives thereof, folic acid, zinc and magnesium, in the manufacture of a preparation for improving the action of receptors. This preparation ...
Monitoring of sleep phenomena
Murata Manufacturing Co., Ltd.
February 16, 2017 - N°20170042471

The present invention relates to method and a system for detecting sleep phenomena, the phenomena including at least one of sleep cycles and sleep disorders such as sleep apnea and hypopnea. Ballistocardiologic signals are detected from a subject person, which provide simultaneous information on heart rate variability (hvv) and stroke volume (sv) of the subject. Values of parameters reflecting measured ...
Pde10 inhibitors and related compositions and methods
Omeros Corporation
January 26, 2017 - N°20170022190

Isolated or pure compounds that inhibit pde10 are disclosed that have utility in the treatment of a variety of conditions, including but not limited to psychotic, anxiety, movement disorders and/or neurological disorders such as parkinson's disease, huntington's disease, alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, bell's palsy, cerebral palsy, sleep disorders, pain, tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and ...
Micro- and nano-quantity sleep enhancing nutrient composition and method of enhancing central nervous system protein ...
Foundational Biosystems, Llc
January 26, 2017 - N°20170020919

The present invention relates to a dietary supplement, composition, nutraceutical, and/or system for inducing or treating biological responses or conditions (namely sleep or sleep disorders) which utilize ultra-low dosage amounts of vitamins, minerals, amino acids, co-enzymes, stimulants, and/or similar ingredients in a highly bio-active delivery system which bypasses first pass metabolism. In particular, the present invention relates to ...
Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders
Procom One, Inc.
January 26, 2017 - N°20170020839

The invention relates to use of the cis-(z) isomer or isomeric mixtures containing specified ratios of the cis-(z) and trans-(e) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders
Spiro-oxazolones
Hoffmann-la Roche Inc.
January 12, 2017 - N°20170008901

The present invention provides spiro-oxazolones, which act as v1a receptor modulators, and in particular as v1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The present compounds are useful as therapeutics acting peripherally and centrally in the conditions of inappropriate secretion of vasopressin, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, ...
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Spiro-oxazolones
Hoffmann-la Roche Inc.
December 08, 2016 - N°20160355522

The present invention provides spiro-oxazolones, which act as v1a receptor modulators, and in particular as v1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The present compounds are useful as therapeutics acting peripherally and centrally in the conditions of inappropriate secretion of vasopressin, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, ...
Flouro-naphthyl derivatives
Hoffmann-la Roche Inc.
November 10, 2016 - N°20160326144

The compounds may be used for the treatment or prophylaxis of alzheimer's disease, cognitive impairment, schizophrenia, pain or sleep disorders.
Automated, snore activated electro-mechanical mandibular advancement device
Hoffmann-la Roche Inc.
November 10, 2016 - N°20160324681

An automated mandibular advancement device (mad) is described for the treatment of sleep disorders involving the occlusion of upper airway gas flow during sleep; one example being obstructive sleep apnea. In embodiments, a mad projects the lower jaw forward only after the patient has fallen asleep. Embodiments of the may track patient sleep parameters for later review by the patient ...
Peptides and pharmaceutical compositions for use in the treatment by nasal administration of patients suffering ...
Max-planck-gesellschaft Zur Forderung Der Wissenschaft E.v.
September 29, 2016 - N°20160279204

The present invention provides peptides for use in a medicament which is administered nasally, wherein the peptide is an agonist of neuropeptide s receptor (npsr), of the receptor tgr23 and/or of vasopressin receptor-related receptor 1 (vrr1) or for use in the treatment of a patient by causing, promoting or increasing relieve or healing of phobic anxiety, avoidance anxiety, dis-sociative anxiety ...
Delivery of drugs
Nanomerics Ltd
September 29, 2016 - N°20160279189

The present invention relates to a composition comprising a hydrophilic drug and an amphiphilic carbohydrate compound for use in therapy wherein the composition is intranasally administered to the human or animal body. The composition can be used to treat a variety of disorders, including schizophrenia, obesity, pain and sleep disorders, psychiatric diseases, neurodegenerative conditions, brain cancers and infective diseases
Method and arrangement for alleviating the stress-related sleep disorder and reducing the stress level of ...
Oy Neurosonic Finland Ltd
August 25, 2016 - N°20160242995

The invention relates to a method for resolving a person's sleep disorders by applying low frequency vibration to a part of the body, said method comprising the use of mechanical vibrators (1) present on a first side of a plate type base member (9) for setting the plate type base member (9) in vibration in such a way that is second surface transmits ...
Aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators
Oy Neurosonic Finland Ltd
August 11, 2016 - N°20160229813

Which are m1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the m1 receptor is involved, such as alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the ...
Humanized anti-acth antibodies and use thereof
Alder Biopharmaceuticals, Inc.
July 28, 2016 - N°20160215049

The present invention is directed to antibodies and fragments thereof having binding specificity for acth. Embodiments of this invention relate to the binding fragments of antibodies described herein, comprising the sequences of the vh, vl and/or cdr polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates anti-acth antibodies and binding fragments thereof conjugated to one or ...