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Sleep Disorders

Sleep Disorders-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
The United States Of America, As Represented By The Secretary, Department Of Health And Human
April 05, 2018 - N°20180093947

Disclosed herein are bisarylmethylthioacetamides and bisarylmethylthioethylamines useful as inhibitors of monoamine transporters. The compounds are potent and/or selective inhibitors of dopamine (da), serotonin (5-ht), and/or norepinephrine (ne) reuptake via their respective transporters, dat, sert and net. Also disclosed are methods for eliciting a wake-promoting or cognitive or attention enhancing effect and for treating substance use disorders, attention deficit (...
Chromane, isochromane and dihydroisobenzofuran derivatives as mglur2-negative allosteric modulators, compositions, and their use
March 29, 2018 - N°20180085358

And ring b, n, r1, r2, r2a, r3, and r3a are as defined herein. The compounds of the invention are useful as mglur2 inhibitors, or mglur2 negative allosteric modulators (nams), and may be useful in methods of treating a patient for diseases or disorders in which the mglur2-nam receptor is involved, such as alzheimer's disease, cognitive impairment, ...
Composition of a 5-ht2a serotonin receptor modulator useful for the treatment of disorders related ...
Arena Pharmaceuticals, Inc
March 29, 2018 - N°20180085351

The present invention relates to certain compositions of a 5-ht2a serotonin receptor modulator and methods for their preparation. The compositions disclosed herein are useful for increasing slow wave sleep, improving sleep consolidation, improving sleep maintenance and improving sleep quality, and for treating insomnia and related sleep disorders, dyssomnias, parasomnias and nonrestorative sleep and the like. The compositions disclosed herein ...
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Compositions of medicinal plants for reducing the effects of aging, prevention and treatment of age-related ...
Pharmacogenetics Limited
March 08, 2018 - N°20180064773

Compositions comprising extracts prepared from mixtures of the herbal plants radix bupleurum chinense dc (“b”), rhizoma corydalis yanhusuo wt wang (“y”), caulis polygonum multiflorum thunb (“p”) and flos albizia julibrissin durazz (“a”) are provided. The byp, bya, bpa, by, bp, yp and bypa extracts ...
V1a antagonists to treat phase shift sleep disorders
Hoffmann-la Roche Inc.
March 08, 2018 - N°20180064727

This invention relates to a new medical use for certain chemical compounds and pharmaceutical compositions containing them. The invention relates to compounds which are selective v1a antagonists for use in the treatment of phase shift sleep disorders, in particular jetlag. In another aspect, the invention relates to a pharmaceutical composition for use in the treatment of phase shift sleep ...
19-nor neuroactive steroids and methods of use thereof
Sage Therapeutics, Inc.
February 22, 2018 - N°20180051052

Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to formula (1): and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance ...
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Substituted pyrazino[2,2-a]isoquinoline derivatives
Hoffmann-la Roche Inc.
February 08, 2018 - N°20180037582

The present invention relates to compounds of formula of formula i wherein r, r1, r2 and l are as described herein, compositions containing compounds of formula i, methods of manufacture of compounds of formula i and methods of treating psychiatric, metabolic, cardiovascular or sleep disorders with compounds of formula i.
Process for the preparation of histamine h3 receptor modulators
Janssen Pharmaceutica Nv
January 25, 2018 - N°20180022704

The present invention is directed to novel processes for the preparation of histamine h3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.
Composition and method for improving sleep duration and quality
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College
January 25, 2018 - N°20180021411

An intervention for sleep disorders comprises: collagen, a gelatin peptide, or the amino acid glycine; l-theanine; lactucopicrin, deoxylactucopicrin, or another lactucopicrin derivative; hyaluronic acid; epigallocatechin gallate; and quinic acid. The intervention helps regulate pro-inflammatory biomarkers that are often associated with insomnia development and progression. These biomarkers include cytokines and enzymes associated with tryptophan degradation. Inhibition of these enzymes and cytokines ...
Imidazolidinedione derivatives
Autifony Therapeutics Limited
January 25, 2018 - N°20180021336

The invention provides a compound of formula (ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of kv3. 1 and/or kv3. 2, and in the treatment of diseases or disorders where a modulator of kv3. 1 and/or kv3. 2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, ...
Mouth closing device
January 11, 2018 - N°20180008452

The present invention relates to a device to urge the mouth closed during sleep to reduce snoring and/or treat sleep disorders such as sleep apnea. In one aspect, the device includes a jaw-blocking object that is secured beneath the chin of a user and also contacting the clavicular region of the upper chest area. In another aspect, a device ...
Methods and systems for diagnosing sleep disorders
Oasis Diagnostics Corporation
January 04, 2018 - N°20180003723

Methods and compositions for risk detection, early diagnosis, prognosis, and monitoring of sleepiness in an individual by measuring the amount of specific biomarkers present in a bodily fluid and comparing them to a reference level of biomarkers in a sample from a healthy person, a person previously diagnosed with sleepiness, or an earlier sample from the individual of interest.
3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof
November 30, 2017 - N°20170342103

Where r1, r2, r3, r3′, r4, r6a, r6a, r11a, and r11b are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, insomnia, anxiety, depression, traumatic brain injury (tbi), stress, and epilepsy.
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Pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of ...
Arena Pharmaceuticals, Inc.
November 09, 2017 - N°20170320831

Pyrazole derivatives of formula (ia) and pharmaceutical compositions thereof that modulate the activity of the serotonin 5ht2a receptor. Formula (ia). Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of insomnia and related sleep disorders, platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot ...
Tetrahydronaphthyridine derivatives as mglur2-negative allosteric modulators, compositions, and their use
Merck Canada Inc.
October 26, 2017 - N°20170305902

The present invention provides quinoline carboxamide and quinoline carbonitrile compounds of formula (i) or a pharmaceutically acceptable salt thereof, wherein r1, r2, l, x1, x2, and x3, are as defined herein. The compounds of the invention, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them, are useful as non-competitive mglur2 antagonists, or mglur2 negative allosteric modulators (nams), and may ...
Combination of valerian root extract and lavender oil for use in the treatment of sleep ...
October 19, 2017 - N°20170296612

The present invention relates to a combination of valerian root extract and lavender oil for treating of sleep disorders, as well as to a combination of preparation comprising valerian root extract and lavender oil.
Removable mandibular myo-stimulator
Achaemenid, Llc
October 12, 2017 - N°20170290699

An oral appliance for the treatment of sleep disorders, such as obstructive sleep apnea, in a user is presented. The oral appliance may include a mouthpiece configured to receive a user's dentition. The mouthpiece may include an oxygen sensor, a pressure sensor, an airflow sensor, an actigraphy sensor, a noise detector, and at least one stimulator for providing stimulation to ...
Apparatus and methods for the treatment of sleep apnea
Lumen Devices, Llc
September 21, 2017 - N°20170266034

A medical apparatus for the treatment of one or more sleep disorders such as obstructive sleep apnea in a patient is provided. The apparatus comprises an elongate member with a middle portion, a first fixation element and a second fixation element. The middle portion applies a force to a segment of a patient's airway.
2-[bis(4-fluorophenyl)methyl]-2,7-diazaspiro[4.5]decan-10-one derivatives and related compounds as inhibitors of ...
Shire International Gmbh
September 14, 2017 - N°20170260185

The present invention provides compounds of formula (i) and in particular 2-[bis(4-fluorophenyl)methyl]-2,7-diazaspiro[4. 5]decan-10-one derivatives and related compounds as inhibitors of human dopamine-active-transporter (dat) protein for the treatment of sexual dysfunction, affective disorders, anxiety, depression, chronic fatigue, tourette syndrome, angelman syndrome, attention deficit disorder (add), attention deficit hyperactivity disorder (adhd), obesity, pain, obsessive-compulsive disorder, movement ...
Compositions and methods for treating insomnia
Eisai R&d Management Co., Ltd.
September 07, 2017 - N°20170252342

In the present invention, compound such as (1r,2s)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-n-(5-fluoropyridin-2-yl) cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well as for other therapeutic uses.
Neuroactive steroids, compositions, and uses thereof
Sage Therapeutics, Inc.
August 31, 2017 - N°20170247406

Described herein are steroids of formula (i): and pharmaceutically acceptable salts thereof; wherein r1, r2a, r2b, r3, r4, r5a, r5b, r6, and z are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, ...
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