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Sleep Disorders

Sleep Disorders-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery ...
August 10, 2017 - N°20170224911

Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, attention deficit disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood ...
Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy
Jazz Pharmaceuticals, Inc.
August 10, 2017 - N°20170224825

Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gammahydroxybutyrate that are also resistant to the conversion into gbl. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of ghb. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of ...
Gamma-hydroxybutyrate compositions and their uses for the treatment of disorders
Jazz Pharmaceuticals Ireland Limited
July 27, 2017 - N°20170209396

Provided herein are pharmaceutical compositions and formulations comprising mixed salts of gamma-hydroxybutyrate (ghb). Also provided herein are methods of making the pharmaceutical compositions and formulations, and methods of their use for the treatment of sleep disorders such as apnea, sleep time disturbances, narcolepsy, cataplexy, sleep paralysis, hypnagogic hallucination, sleep arousal, insomnia, and nocturnal myoclonus.
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Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery ...
Intra-cellular Therapies, Inc.
June 29, 2017 - N°20170182299

Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, attention deficit disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood ...
New uses of ganaxolone
Wisconsin Alumni Research Foundation
June 29, 2017 - N°20170182061

Absence epilepsy, a form of epilepsy characterized by nonconvulsive seizures, has proven to be refractive to conventional epilepsy therapies. It has been found that low doses of ganaxolone can be used to reduce absence seizures in subjects with absence epilepsy, particularly pediatric subjects. In addition, ganaxolone therapy is particularly useful in subjects with absence epilepsy characterized by a reduction in ...
Cardio-kinetic cross-spectral density for assessment of sleep physiology
Lifeq Global Limited
June 29, 2017 - N°20170181691

The invention comprises methods and systems capable of processing simultaneously measured cardiac and motion signals, selecting from said signals the optimal cardiac and motion signal combination for cross spectral density calculations and, hereafter, itemizing the shared information in terms of the individual constituent frequencies and the effect exerted upon said frequencies by common underlying physiological states. The information is passed ...
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Botulinum toxin and the treatment of primary disorders of mood and affect
Revance Therapeutics, Inc.
June 15, 2017 - N°20170165330

The invention provides methods for treating primary disorders of mood and affect, including depressive disorders, anxiety and sleep disorders and cns disorders comprising the administration of a neurotoxin.
Three-phase controlled-release tablet comprising melatonin and process of preparation
Ambros Pharma S.r.l.
June 15, 2017 - N°20170165232

The invention relates, in one aspect, to a tablet having an internal core and external coating, both comprising melatonin and separated by an internal coating which does not comprise melatonin. The tablet is useful as a medicinal product, dietetic or food supplements for the treatment or as adjunctive therapy in sleep disorders.
Pde10 inhibitors and related compositions and methods
Omeros Corporation
June 01, 2017 - N°20170152238

Compounds that inhibit pde10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as parkinson's disease, huntington's disease, alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, bell's palsy, cerebral palsy, sleep disorders, pain, tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive ...
Imidazo[1,2-a]pyridine derivatives as modulators of the 5-ht2a serotonin receptor useful for the ...
Arena Pharmaceuticals, Inc.
June 01, 2017 - N°20170151236

Imidazo[1,2-a]pyridine derivatives of formula (ia) and pharmaceutical compositions thereof that modulate the activity of the 5-ht2a serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of insomnia, dyssomnia, parasomnia and related sleep disorders, platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, thrombosis, asthma or symptoms ...
Substituted pyrazino[2,2-a]isoquinoline derivatives
Arena Pharmaceuticals, Inc.
May 25, 2017 - N°20170145010

The present invention relates to compounds of formula of formula i wherein r, r2and l are as described herein, compositions containing compounds of formula i, methods of manufacture of compounds of formula i and methods of treating psychiatric, metabolic, cardiovascular or sleep disorders with compounds of formula i.
Substituted azetidine derivatives
Arena Pharmaceuticals, Inc.
May 25, 2017 - N°20170144994

The present invention relates to compounds of formula of formula i wherein r, r1. R2, r2′, r3, r4, r5, l1, l2 and n are as described herein, compositions containing compounds of formula i, methods of manufacture of compounds of formula i and methods of treating psychiatric, metabolic, cardiovascular or sleep disorders with compounds of formula i.
Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolythic feed-through, lead assembly and anchoring ...
Arena Pharmaceuticals, Inc.
May 25, 2017 - N°20170143959

An implantable medical device is provided for the suppression or prevention of pain, movement disorders, epilepsy, cerebrovascular diseases, autoimmune diseases, sleep disorders, autonomic disorders, abnormal metabolic states, disorders of the muscular system, and neuropsychiatric disorders in a patient. The implantable medical device can be a neurostimulator configured to be implanted on or near a cranial nerve to treat headache or ...
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Sleep Disorders Patent Applications
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Combination airflow, sound and pulse wave sensor pack with smartphone data aquisition and transfer
Dymedix Corporation
March 23, 2017 - N°20170079580

The system of the present invention is intended to provide a simple, out-of-clinic sleep disorders testing tool. It can be used for pretest screening and diagnosis, and post therapy follow-up of patients. The hardware component comprises a disposable sensor pack containing a pvdf airflow sensor and a pvdf pulse wave sensor, each of which is permanently connected to a signal ...
Fast dissolving granulate
Boehringer Ingelheim International Gmbh
March 16, 2017 - N°20170072001

The invention relates to a fast dissolving granulate obtainable by spray-dying of a composition comprising a dry methanolic or ethanolic extract of valerian root, a dry methanolic extract of hop strobiles, optionally a carrier, one or more artificial sweeteners, one or more flavoring agents, optionally an acidifier and water for the treatment of sleep disorders, wherein the said granulate is ...
Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
Janssen Pharmaceutica Nv
March 16, 2017 - N°20170071970

The present invention is directed to the use of co-therapy comprising administration of canagliflozin and phentermine for the treatment of obesity and obesity related disorders. More particularly, the present invention is directed to co-therapy for treating obesity, for promoting weight loss and/or for suppressing appetite; for treating, delaying, slowing the progression of and/or preventing metabolic disorders (including for ...
Imidazolidinedione derivatives
Autifony Therapeutics Limited
March 09, 2017 - N°20170065585

The invention provides a compound of formula (ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of kv3. 1 and/or kv3. 2, and in the treatment of diseases or disorders where a modulator of kv3. 1 and/or kv3. 2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, ...
Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep ...
Procom One, Inc.
March 09, 2017 - N°20170065551

The invention relates to use of the trans-(e) isomer or isomeric mixtures containing specified ratios of the trans-(e) and cis-(z) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders
Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof
Paratek Pharmaceuticals, Inc.
March 09, 2017 - N°20170065517

The present invention provides novel compositions for the delivery of a hypnotic agent across the oral mucosa. In particular, the buffer system in the compositions of the present invention raises the ph of saliva to a ph greater than about 7. 8, thereby facilitating the substantially complete conversion of the hypnotic agent from its ionized to its un-ionized form. As a result, ...
Heteroaromatic compounds and their use as dopamine d1 ligands
Paratek Pharmaceuticals, Inc.
March 02, 2017 - N°20170057947

And pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating d1-mediated (or d1-associated) disorders including, e. G., schizophrenia (e. G., its cognitive and negative symptoms), cognitive impairment (e. G., cognitive impairment associated with schizophrenia, ad, pd, or pharmacotherapy therapy), adhd, ...
Process for the preparation of histamine h3 receptor modulators
Janssen Pharmaceutica Nv
March 02, 2017 - N°20170057919

The present invention is directed to novel processes for the preparation of histamine h3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.
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