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Sleep Disorders

Sleep Disorders-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Removable mandibular myo-stimulator
Achaemenid, Llc
October 12, 2017 - N°20170290699

An oral appliance for the treatment of sleep disorders, such as obstructive sleep apnea, in a user is presented. The oral appliance may include a mouthpiece configured to receive a user's dentition. The mouthpiece may include an oxygen sensor, a pressure sensor, an airflow sensor, an actigraphy sensor, a noise detector, and at least one stimulator for providing stimulation to ...
Apparatus and methods for the treatment of sleep apnea
Lumen Devices, Llc
September 21, 2017 - N°20170266034

A medical apparatus for the treatment of one or more sleep disorders such as obstructive sleep apnea in a patient is provided. The apparatus comprises an elongate member with a middle portion, a first fixation element and a second fixation element. The middle portion applies a force to a segment of a patient's airway.
2-[bis(4-fluorophenyl)methyl]-2,7-diazaspiro[4.5]decan-10-one derivatives and related compounds as inhibitors of ...
Shire International Gmbh
September 14, 2017 - N°20170260185

The present invention provides compounds of formula (i) and in particular 2-[bis(4-fluorophenyl)methyl]-2,7-diazaspiro[4. 5]decan-10-one derivatives and related compounds as inhibitors of human dopamine-active-transporter (dat) protein for the treatment of sexual dysfunction, affective disorders, anxiety, depression, chronic fatigue, tourette syndrome, angelman syndrome, attention deficit disorder (add), attention deficit hyperactivity disorder (adhd), obesity, pain, obsessive-compulsive disorder, movement ...
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Neuroactive steroids, compositions, and uses thereof
Sage Therapeutics, Inc.
August 31, 2017 - N°20170247406

Described herein are steroids of formula (i): and pharmaceutically acceptable salts thereof; wherein r1, r2a, r2b, r3, r4, r5a, r5b, r6, and z are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, ...
19-nor c3, 3-disubstituted c21-n-pyrazolyl steroids and methods of use thereof
Sage Therapeutics, Inc.
August 31, 2017 - N°20170246191

And pharmaceutically acceptable salts thereof; wherein , r1, r2, r3a, r3b, r4a, r4b, r5, r6, and r7 are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement ...
Spiro-thiazolones
Sage Therapeutics, Inc.
August 31, 2017 - N°20170246153

Wherein x1, x2, x3, x4, r2, r3, r4, r5, r6 and r7 are as defined herein, which act as v1a receptor modulators, and in particular as v1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments for treatment of inappropriate secretion of vasopressin, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, aggressive ...
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Prevention or treatment of sleep disorders using dexmedetomidine formulation
Bioxcel Corporation
August 24, 2017 - N°20170239221

There is provided a composition suitable for oral transmucosal administration (sublingual) comprising dexmedetomidine. The composition is useful for the treatment of sleep disorders such as insomnia and capable of providing sleep on demand. The composition comprises an effective amount of dexmedetomidine or pharmaceutically acceptable salts thereof, solvates thereof, or derivatives thereof, formulated for delivery of dexmedetomidine across a subject's oral ...
19-nor neuroactive steroids and methods of use thereof
Bioxcel Corporation
August 17, 2017 - N°20170233432

And pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, tinnitus, status epilepticus.
System and method for delivering a therapy and sensing a biological activity in the mouth
Scientific Partners, Llc
August 17, 2017 - N°20170231807

Methods, devices, and systems are disclosed for controlled delivery of a therapy, such as a stimulant, to a mouth of a subject via an oral device positioned in a secured configuration in the mouth. At least one of a tongue position stimulator (tst) and tongue position sensor (tse) is provided, according to certain aspects. According to another aspect, a stimulus ...
Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery ...
Scientific Partners, Llc
August 10, 2017 - N°20170224911

Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, attention deficit disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood ...
Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy
Jazz Pharmaceuticals, Inc.
August 10, 2017 - N°20170224825

Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gammahydroxybutyrate that are also resistant to the conversion into gbl. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of ghb. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of ...
Gamma-hydroxybutyrate compositions and their uses for the treatment of disorders
Jazz Pharmaceuticals Ireland Limited
July 27, 2017 - N°20170209396

Provided herein are pharmaceutical compositions and formulations comprising mixed salts of gamma-hydroxybutyrate (ghb). Also provided herein are methods of making the pharmaceutical compositions and formulations, and methods of their use for the treatment of sleep disorders such as apnea, sleep time disturbances, narcolepsy, cataplexy, sleep paralysis, hypnagogic hallucination, sleep arousal, insomnia, and nocturnal myoclonus.
Methods and compositions for sleep disorders and other disorders
Intra-cellular Therapies, Inc.
July 06, 2017 - N°20170189398

Use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals and pharmaceutical compositions comprising them for the treatment of one or more disorders involving the 5-ht2a, sert and/or dopamine d2 pathways are disclosed. In addition, the compounds may be combined with other therapeutic agents for the treatment of one or more sleep disorders, depression, psychosis, dyskinesias, and/or ...
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New uses of ganaxolone
Wisconsin Alumni Research Foundation
June 29, 2017 - N°20170182061

Absence epilepsy, a form of epilepsy characterized by nonconvulsive seizures, has proven to be refractive to conventional epilepsy therapies. It has been found that low doses of ganaxolone can be used to reduce absence seizures in subjects with absence epilepsy, particularly pediatric subjects. In addition, ganaxolone therapy is particularly useful in subjects with absence epilepsy characterized by a reduction in ...
Cardio-kinetic cross-spectral density for assessment of sleep physiology
Lifeq Global Limited
June 29, 2017 - N°20170181691

The invention comprises methods and systems capable of processing simultaneously measured cardiac and motion signals, selecting from said signals the optimal cardiac and motion signal combination for cross spectral density calculations and, hereafter, itemizing the shared information in terms of the individual constituent frequencies and the effect exerted upon said frequencies by common underlying physiological states. The information is passed ...
Botulinum toxin and the treatment of primary disorders of mood and affect
Revance Therapeutics, Inc.
June 15, 2017 - N°20170165331

The invention provides methods for treating primary disorders of mood and affect, including depressive disorders, anxiety and sleep disorders and cns disorders comprising the administration of a neurotoxin.
Botulinum toxin and the treatment of primary disorders of mood and affect
Revance Therapeutics, Inc.
June 15, 2017 - N°20170165330

The invention provides methods for treating primary disorders of mood and affect, including depressive disorders, anxiety and sleep disorders and cns disorders comprising the administration of a neurotoxin.
Three-phase controlled-release tablet comprising melatonin and process of preparation
Ambros Pharma S.r.l.
June 15, 2017 - N°20170165232

The invention relates, in one aspect, to a tablet having an internal core and external coating, both comprising melatonin and separated by an internal coating which does not comprise melatonin. The tablet is useful as a medicinal product, dietetic or food supplements for the treatment or as adjunctive therapy in sleep disorders.
Pde10 inhibitors and related compositions and methods
Omeros Corporation
June 01, 2017 - N°20170152238

Compounds that inhibit pde10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as parkinson's disease, huntington's disease, alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, bell's palsy, cerebral palsy, sleep disorders, pain, tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive ...
Imidazo[1,2-a]pyridine derivatives as modulators of the 5-ht2a serotonin receptor useful for the ...
Arena Pharmaceuticals, Inc.
June 01, 2017 - N°20170151236

Imidazo[1,2-a]pyridine derivatives of formula (ia) and pharmaceutical compositions thereof that modulate the activity of the 5-ht2a serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of insomnia, dyssomnia, parasomnia and related sleep disorders, platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, thrombosis, asthma or symptoms ...
Substituted pyrazino[2,2-a]isoquinoline derivatives
Arena Pharmaceuticals, Inc.
May 25, 2017 - N°20170145010

The present invention relates to compounds of formula of formula i wherein r, r2and l are as described herein, compositions containing compounds of formula i, methods of manufacture of compounds of formula i and methods of treating psychiatric, metabolic, cardiovascular or sleep disorders with compounds of formula i.
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