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Sleep Disorders

Sleep Disorders-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Botulinum toxin and the treatment of primary disorders of mood and affect
Revance Therapeutics, Inc.
June 15, 2017 - N°20170165331

The invention provides methods for treating primary disorders of mood and affect, including depressive disorders, anxiety and sleep disorders and cns disorders comprising the administration of a neurotoxin.
Botulinum toxin and the treatment of primary disorders of mood and affect
Revance Therapeutics, Inc.
June 15, 2017 - N°20170165330

The invention provides methods for treating primary disorders of mood and affect, including depressive disorders, anxiety and sleep disorders and cns disorders comprising the administration of a neurotoxin.
Three-phase controlled-release tablet comprising melatonin and process of preparation
Ambros Pharma S.r.l.
June 15, 2017 - N°20170165232

The invention relates, in one aspect, to a tablet having an internal core and external coating, both comprising melatonin and separated by an internal coating which does not comprise melatonin. The tablet is useful as a medicinal product, dietetic or food supplements for the treatment or as adjunctive therapy in sleep disorders.
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Imidazo[1,2-a]pyridine derivatives as modulators of the 5-ht2a serotonin receptor useful for the ...
Arena Pharmaceuticals, Inc.
June 01, 2017 - N°20170151236

Imidazo[1,2-a]pyridine derivatives of formula (ia) and pharmaceutical compositions thereof that modulate the activity of the 5-ht2a serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of insomnia, dyssomnia, parasomnia and related sleep disorders, platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, thrombosis, asthma or symptoms ...
Substituted pyrazino[2,2-a]isoquinoline derivatives
Arena Pharmaceuticals, Inc.
May 25, 2017 - N°20170145010

The present invention relates to compounds of formula of formula i wherein r, r2and l are as described herein, compositions containing compounds of formula i, methods of manufacture of compounds of formula i and methods of treating psychiatric, metabolic, cardiovascular or sleep disorders with compounds of formula i.
Substituted azetidine derivatives
Arena Pharmaceuticals, Inc.
May 25, 2017 - N°20170144994

The present invention relates to compounds of formula of formula i wherein r, r1. R2, r2′, r3, r4, r5, l1, l2 and n are as described herein, compositions containing compounds of formula i, methods of manufacture of compounds of formula i and methods of treating psychiatric, metabolic, cardiovascular or sleep disorders with compounds of formula i.
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2-oxa-5-azabicyclo[2.2.1]heptan-3-yl derivatives
Hoffmann-la Roche Inc.
May 18, 2017 - N°20170137435

The present invention relates to compounds of formula of formula i wherein x, l and r1 are as described herein, compositions containing compounds of formula i, methods of manufacture of compounds of formula i and methods of treating psychiatric, metabolic, cardiovascular or sleep disorders with compounds of formula i.
Combination airflow, sound and pulse wave sensor pack with smartphone data aquisition and transfer
Dymedix Corporation
March 23, 2017 - N°20170079580

The system of the present invention is intended to provide a simple, out-of-clinic sleep disorders testing tool. It can be used for pretest screening and diagnosis, and post therapy follow-up of patients. The hardware component comprises a disposable sensor pack containing a pvdf airflow sensor and a pvdf pulse wave sensor, each of which is permanently connected to a signal ...
Fast dissolving granulate
Boehringer Ingelheim International Gmbh
March 16, 2017 - N°20170072001

The invention relates to a fast dissolving granulate obtainable by spray-dying of a composition comprising a dry methanolic or ethanolic extract of valerian root, a dry methanolic extract of hop strobiles, optionally a carrier, one or more artificial sweeteners, one or more flavoring agents, optionally an acidifier and water for the treatment of sleep disorders, wherein the said granulate is ...
Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
Janssen Pharmaceutica Nv
March 16, 2017 - N°20170071970

The present invention is directed to the use of co-therapy comprising administration of canagliflozin and phentermine for the treatment of obesity and obesity related disorders. More particularly, the present invention is directed to co-therapy for treating obesity, for promoting weight loss and/or for suppressing appetite; for treating, delaying, slowing the progression of and/or preventing metabolic disorders (including for ...
Imidazolidinedione derivatives
Autifony Therapeutics Limited
March 09, 2017 - N°20170065585

The invention provides a compound of formula (ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of kv3. 1 and/or kv3. 2, and in the treatment of diseases or disorders where a modulator of kv3. 1 and/or kv3. 2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, ...
Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep ...
Procom One, Inc.
March 09, 2017 - N°20170065551

The invention relates to use of the trans-(e) isomer or isomeric mixtures containing specified ratios of the trans-(e) and cis-(z) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders
Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof
Paratek Pharmaceuticals, Inc.
March 09, 2017 - N°20170065517

The present invention provides novel compositions for the delivery of a hypnotic agent across the oral mucosa. In particular, the buffer system in the compositions of the present invention raises the ph of saliva to a ph greater than about 7. 8, thereby facilitating the substantially complete conversion of the hypnotic agent from its ionized to its un-ionized form. As a result, ...
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Process for the preparation of histamine h3 receptor modulators
Janssen Pharmaceutica Nv
March 02, 2017 - N°20170057919

The present invention is directed to novel processes for the preparation of histamine h3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.
Preparation for improving the action of receptors
N.v. Nutricia
February 16, 2017 - N°20170042852

The present invention relates to the use of polyunsaturated fatty acids and one or more components which have a beneficial effect on total methionine metabolism selected from the group consisting of vitamin b 12 and precursors thereof, vitamin b6 and derivatives thereof, folic acid, zinc and magnesium, in the manufacture of a preparation for improving the action of receptors. This preparation ...
Monitoring of sleep phenomena
Murata Manufacturing Co., Ltd.
February 16, 2017 - N°20170042471

The present invention relates to method and a system for detecting sleep phenomena, the phenomena including at least one of sleep cycles and sleep disorders such as sleep apnea and hypopnea. Ballistocardiologic signals are detected from a subject person, which provide simultaneous information on heart rate variability (hvv) and stroke volume (sv) of the subject. Values of parameters reflecting measured ...
Pde10 inhibitors and related compositions and methods
Omeros Corporation
January 26, 2017 - N°20170022190

Isolated or pure compounds that inhibit pde10 are disclosed that have utility in the treatment of a variety of conditions, including but not limited to psychotic, anxiety, movement disorders and/or neurological disorders such as parkinson's disease, huntington's disease, alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, bell's palsy, cerebral palsy, sleep disorders, pain, tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and ...
Micro- and nano-quantity sleep enhancing nutrient composition and method of enhancing central nervous system protein ...
Foundational Biosystems, Llc
January 26, 2017 - N°20170020919

The present invention relates to a dietary supplement, composition, nutraceutical, and/or system for inducing or treating biological responses or conditions (namely sleep or sleep disorders) which utilize ultra-low dosage amounts of vitamins, minerals, amino acids, co-enzymes, stimulants, and/or similar ingredients in a highly bio-active delivery system which bypasses first pass metabolism. In particular, the present invention relates to ...
Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders
Procom One, Inc.
January 26, 2017 - N°20170020839

The invention relates to use of the cis-(z) isomer or isomeric mixtures containing specified ratios of the cis-(z) and trans-(e) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders
Spiro-oxazolones
Hoffmann-la Roche Inc.
January 12, 2017 - N°20170008901

The present invention provides spiro-oxazolones, which act as v1a receptor modulators, and in particular as v1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The present compounds are useful as therapeutics acting peripherally and centrally in the conditions of inappropriate secretion of vasopressin, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, ...
System and method of detecting sleep disorders
Hoffmann-la Roche Inc.
December 22, 2016 - N°20160367203

An apparatus for detecting sleep disorders, such as obstructive sleep apnea, includes a housing insertable into an ear canal of a subject. A sensor disposed within the housing measures a position of the subject's head relative to an axis of gravity. A transducer is responsive to the sensor and is capable of creating a stimulus detectable by the subject under ...
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