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Sit-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Nutritional formulations including human milk oligosaccharides and antioxidants and uses thereof
Abbott Laboratories
June 14, 2018 - N°20180161351

Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.. .
Arginase inhibitor combination therapies
Calithera Biosciences, Inc.
June 14, 2018 - N°20180161349

The disclosure relates to methods of treating or preventing a disease in a subject by conjointly administering to the subject an arginase inhibitor disclosed herein and a composition comprising immune cells disclosed herein.. .
Estriol therapy for treatment of multiple sclerosis
The Regents Of The University Of California
June 14, 2018 - N°20180161346

The present invention discloses administering steroid hormones to mammals to treat autoimmune related diseases, including post-partum auto immune diseases. Most preferably the invention uses estrogens, estranges, estriol or estrogen receptor active agents to prevent or ameliorate clinical symptoms of these th1-mediated (cell-mediated) autoimmune diseases known to either have an initial onset following the birth of a child or which ...
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Vaginal inserted estradiol pharmaceutical compositions and methods
Therapeuticsmd, Inc.
June 14, 2018 - N°20180161344

In one aspect, compositions and methods for the treatment of vulvovaginal atrophy (vva) are provided. In one embodiment, the method comprises administering an estrogen to a subject having vva by inserting a dosage form comprising a liquid pharmaceutical composition..
Vaginal inserted estradiol pharmaceutical compositions and methods
Therapeuticsmd, Inc.
June 14, 2018 - N°20180161343

In one aspect, compositions and methods for the treatment of vulvovaginal atrophy (vva) are provided. In one embodiment, the method comprises administering an estrogen to a subject having vva by inserting a dosage form comprising a liquid pharmaceutical composition..
Prostamide-containing intraocular implant
Allergan, Inc.
June 14, 2018 - N°20180161342

Prostamide-containing biodegradable intraocular implants, prostamide compounds, prostamide-containing pharmaceutical compositions, and methods for making and using such implants and compositions for the immediate and sustained reduction of intraocular pressure and treatment of glaucoma in an eye of a patient are described.. .
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Methods and compositions for the prevention and treatment of hearing loss
St. Jude Children's Research Hospital
June 14, 2018 - N°20180161340

In one aspect, pharmaceutical compositions comprising a cdk2 inhibitor and one or more of at least one agent known to treat a hearing impairment and at least one agent known to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for ...
Use of carbonic anhydrase inhibitors for treatment of neurological and psychiatric disorders
New York University
June 14, 2018 - N°20180161339

The invention is directed to the use of carbonic anhydrase inhibitors for treatment of neurological and psychiatric disorders.. .
Novel bicyclic bromodomain inhibitors
Zenith Epigenetics Ltd.
June 14, 2018 - N°20180161337

The invention relates to substituted bicyclic compounds, which are useful for inhibition of bet protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.. .
Dna-pk inhibitors
Vertex Pharmaceuticals Incorporated
June 14, 2018 - N°20180161336

The present invention relates to compounds useful as inhibitors of dna-pk. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders..
Methods to treat neurological diseases
University Of Southern California
June 14, 2018 - N°20180161335

Disclosed is a method of treating a subject who has a neurological disease. The neurological disease may be associated with altered c9orf72 protein activity.
Inhibitors of macropinocytosis in prevention and treatment of disease
Texas Biomedical Research Institute
June 14, 2018 - N°20180161333

Described herein are pharmaceutical compositions capable of inhibiting vesicle formation and methods of treatment or prophylactic administration of these pharmaceutical compositions to treat pathogenic infections.. .
Treatment of mitochondrial diseases
Centro De InvestigaciÓn BiomÉdica En Red
June 14, 2018 - N°20180161332

The present invention provides a composition comprising one or more deoxyribonucleosides for use in the treatment of a mitochondrial dna depletion and/or multiple deletions syndrome provided that the syndrome is not caused by a defect in the deoxyribonucleoside triphosphate (dntp) metabolism. With the use of the invention there is a recovery in mitochondrial dna levels independently from the severity ...
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Treatment of cancer and benign proliferative disorders
The University Of Manchester
June 14, 2018 - N°20180161328

Disclosed herein are compositions comprising lopinavir alone or in combination with ritonavir for use as a medicament in the treatment of cancer or benign proliferative disorders (warts) or in the prevention of the development of cancer. Pharmaceutical compositions formulated for topical application comprising a therapeutically effective amount of lopinavir or a therapeutically effective amount lopinavir and ritonavir in a pharmaceutically ...
Pac-1 combination therapy
The Board Of Trustees Of The University Of Lllinois
June 14, 2018 - N°20180161326

The invention provides compositions and methods for the induction of cancer cell death. The compositions and methods of using them include use of compositions in therapy for the treatment of cancer and for the selective induction of apoptosis in cancer cells.
Pharmaceutical formulation containing tadalafil
Druggability Technologies Ip Holdco Limited
June 14, 2018 - N°20180161325

Disclosed herein are pharmaceutical compositions comprising tadalafil, or a salt, or derivatives thereof and pharmaceutical excipients, processes for the preparation thereof, and pharmaceutical compositions containing them. The pharmaceutical compositions have improved physicochemical properties that provide faster onset of action for the treatment of erectile dysfunction..
Ship1 modulators and methods related thereto
June 14, 2018 - N°20180161324

N, r1, r4a, r4b, r5, r7 and r8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as ship1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from ship1 modulation.
Trazodone and trazodone hydrochloride in purified form
Aziende Chimiche Riunite Angelini Francesco A.c.r.a.f. S.p.a.
June 14, 2018 - N°20180161323

A process of production of trazodone or trazodone hydrochloride that comprises: (a) preparing an organic phase comprising trazodone in at least one organic solvent; (b) preparing an aqueous phase comprising at least one basic compound; (c) mixing said aqueous phase with said organic phase; (d) heating at a temperature of at least 40° c. For at least 30 minutes; (e) recovering ...
Pharmaceutical composition
Sumitomo Dainippon Pharma Co., Ltd.
June 14, 2018 - N°20180161322

A preparation for oral administration comprising: a pregelatinized starch comprising n-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]-(2r,3r)-2,3-tetramethylene-butyl]-(1′r,2′s,3′r,4′s)-2,3-bicyclo[2,2,1]-heptanedicarboxyimide hydrochloride (lurasidone) represented by the formula (1) as an active ingredient; a water-soluble excipient; and a water-soluble polymeric binder, the preparation exhibiting an invariant level of elution ...
Intranasal naloxone compositions and methods of making and using same
Antiop, Inc.
June 14, 2018 - N°20180161320

Disclosed herein are compositions containing an opioid antagonist such as naloxone and one or more pharmaceutically acceptable excipients. The compositions may be used for intranasal delivery of naloxone for the treatment of, for example, opioid overdose in an individual in need thereof.
Pharmaceutical composition for preventing and treating obesity or liver diseases, containg tlr7 agonist
Knotus Life Science Inc.
June 14, 2018 - N°20180161318

The present invention is based on the fact that imiquimod, which is a substance that enhances toll-like receptor 7 (tlr7) related to the innate immunity of a living body, is effective in the prevention and treatment of obesity or liver disease, and the present invention relates to a pharmaceutical composition for the prevention and treatment of obesity or liver disease, wherein ...
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