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Single Nucleotide Polymorphism patents

      

This page is updated frequently with new Single Nucleotide Polymorphism-related patent applications.




 Compositions, methods, and systems for inferring bovine breed patent thumbnailCompositions, methods, and systems for inferring bovine breed
Provided herein are methods to discover and use single nucleotide polymorphisms (snp) for identifying breed, or line and breed, or line composition of a bovine subject. The present invention further provides specific nucleic acid sequences, snps, and snp patterns that can be used for identifying breed or breed combinations for angus, holstein, limousin, brahman, hereford, simmental, gelbvieh, charolais and beefmaster breeds.
Branhaven Llc


 Multivalent probes having single nucleotide resolution patent thumbnailMultivalent probes having single nucleotide resolution
The present invention relates to, among other things, polymer strands, probes, compositions, methods, and kits for enabling accurate and robust enzyme- and amplification-free detection of dna and rna with single base resolution (e.g., detection of a single nucleotide polymorphism (snp), an insertion, and a deletion). The compositions, methods, and kits may further provide simultaneous detection of dna and/or rna and protein targets..
Nanostring Technologies, Inc.


 Methods of diagnosing increased risk of developing mrsa patent thumbnailMethods of diagnosing increased risk of developing mrsa
A method for diagnosing increased risk of developing methicillin-resistant staphylococcus aureus (mrsa) hospital-acquired (ha-mrsa) or community-acquired mrsa (ca-mrsa) which includes obtaining a biological sample from a subject, detecting in the sample a single nucleotide polymorphism (snp) in the fam129b gene at position 17 of seq id no 1, and comparing the nucleotide at position 17 of seq id no. 1 in the sample with the nucleotide at position 17 in seq id no.
William Beaumont Hospital


 Melting curve analysis using pna probe, method and kit for analyzing nucleotide polymorphism using melting curve analysis patent thumbnailMelting curve analysis using pna probe, method and kit for analyzing nucleotide polymorphism using melting curve analysis
Provided are a pna probe for detecting nucleotide polymorphism of a target gene, a melting curve analysis method for detecting the nucleotide polymorphism of the target gene using the same, a nucleotide polymorphism analysis method of a target gene including the melting curve analysis method, and a kit for detecting the nucleotide polymorphism of the target gene containing the pna probe. It is characterized that the pna probe according to the present invention contains negative charge molecules.
Panagene Inc.


 Strand exchange hairpin primers that give high allelic discrimination patent thumbnailStrand exchange hairpin primers that give high allelic discrimination
Provided herein are compositions and methods for identification of the presence or absence of a particular sequence, such as a single nucleotide polymorphism. Employed herein are particular primers that comprise a hairpin and a single strand extension at the 3′ end, the single strand extension in which at least one nucleotide is mismatched compared to a target particular sequence.
The Board Of Regents Of The University Of Texas System


 Detection of nucleic acid reactions on bead arrays patent thumbnailDetection of nucleic acid reactions on bead arrays
The present invention is directed to methods and compositions for the use of microsphere arrays to detect and quantify a number of nucleic acid reactions. The invention finds use in genotyping, i.e.
Illumina, Inc


 Determining prostate cancer recurrence using polymorphisms in angiogenesis-related genes patent thumbnailDetermining prostate cancer recurrence using polymorphisms in angiogenesis-related genes
In particular, disclosed is a method for treating a patient with prostate cancer that involves genotyping a nucleic acid sample from the subject for one or more single nucleotide polymorphism (snp) alleles in one or more genes angiogenesis, comparing the one or more snp alleles to control allele frequencies to produce a snp signature, and analyzing the snp signature to generate a risk score. The risk score can represent the likelihood that the patient's prostate cancer will recur following radical prostatectomy.
H. Lee Moffitt Cancer Center And Research Institute, Inc.


 Methods for assessing risk of alzheimer's disease in a patient patent thumbnailMethods for assessing risk of alzheimer's disease in a patient
Disclosed are methods for diagnosis or prognosis of alzheimer's disease in a patient. The methods may include assessing whether a patient has alzheimer's disease or assessing a patient's risk for developing alzheimer's disease.
Wisconsin Alumni Research Foundation


 Single nucleotide polymorphisms (snp) and association with resistance to immune tolerance induction patent thumbnailSingle nucleotide polymorphisms (snp) and association with resistance to immune tolerance induction
This application discloses methods, systems and kits for correlating the presence or absence of certain nucleic acid sequences within a population with the ability to create immune tolerance in that same population. Tolerance can be induced by solo or repeated administration of antigen, including soluble antigens administered either intravenously or sublingually.
University Of Tennessee Research Foundation


 Compositions and methods for identifying altered effectiveness of beta blocker therapy patent thumbnailCompositions and methods for identifying altered effectiveness of beta blocker therapy
The present invention provides a method of identifying a human subject as having an increased risk of altered effectiveness of beta blocker therapy, comprising detecting in the subject one or more single nucleotide polymorphism associated with increased risk of altered effectiveness of beta blocker therapy.. .
Duke University


Serotonin transporter gene and treatment of alcoholism

The gene responsible for encoding sert has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (l) and short (s). The ll-genotype is hypothesized to play a key role in the early onset of alcohol use.
University Of Virginia Patent Foundation

Single nucleotide polymorphism in hla-b*15:02 and use thereof

Disclosed herein is a novel single nucleotide polymorphism (snp) in hla-b*15:02 that can be used as a biomarker for carbamazepine-induced severe adverse skin reactions in asians. Also provided herein are methods and reagents for assessing the specific snp, and applying the snp in predicting an increased risk of carbamazepine-induced severe adverse skin reactions..
Millennium Health, Llc

Quantitative analysis method using microorganism 16s rdna gene having single nucleotide polymorphism

The present invention relates to utilization of an artificially synthesized nucleic acid, and more particularly, to a quantitative analysis method capable of quantitatively adjusting gene-based microbial community analysis results by preparing a microorganism 16s rdna gene, which has a single nucleotide polymorphism (snp) at a particular location so as to be differentiated from a gene of a target microorganism on the nucleotide sequence, and then using the microorganism 16s rdna gene as an internal standard material which is quantifiable through nucleotide sequencing.. .
Korea Research Institute Of Standards And Science

Detection kit for identifying genotype in depression patients and using the same

The present invention relates to a rs6311 test kit, which includes a probe, a primer, and a polymerase chain reaction solution, wherein said probe sequence is as follows: rs6311t-fam: ctgtgagtgtctggc (seq. Id.

Microrna polymorphisms conferring enhanced drought tolerance in a plant

Methods of identifying a single nucleotide polymorphism associated with a plant trait and methods of identifying a plant having an improved trait. The plant trait is correlated with at least one single nucleotide polymorphism in a microrna region of a plant genome.
Syngenta Participations Ag

High-resolution melting analysis

The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of nucleic acids. Methods and systems are disclosed for identifying a nucleic acid in a sample including an unknown nucleic acid and for detecting a single nucleotide polymorphism in a nucleic acid in a sample.
Canon U.s. Life Sciences, Inc.

Detecting single nucleotide polymorphism using overlapping hydrolysis probes

Methods for the rapid detection of the presence or absence of a snp in a target nucleic acid in a sample are described. The methods can include performing an amplifying step, a hybridizing step utilizing a double stranded probe with two overlapping snp specific hydrolysis probe sequences where one of the probe sequences can include a hairpin structure toward the 3′ end, and a detecting step.
Roche Molecular Systems, Inc.

Methods of weight analysis and uses thereof

Disclosed herein are weight analysis methods and assays, which objectively identify biological strengths and weaknesses in a patient's genetic coding that affect their weight. The generated results can be utilized to develop a personalized weight and nutritional regimen to regulate weight and prevent, reduce and treat weight disorders and diseases.

Method for testing a mutant gene through real time polymerase chain reaction using inhibition of 5'-flap endonuclease activity

The present invention relates to a method for detecting single nucleotide polymorphism (snp) using a feature that the 5′-flap endonuclease (fen) activity of dna polymerase is inhibited when a probe complementarily binds to the end of a polymerase chain reaction (pcr) product. More specifically, the present invention relates to a novel method wherein it was verified that, when a probe used for a real-time pcr complementarily binds to the end site of a pcr product, the 5′-fen activity of thermostable dna polymerase to the probe is inhibited, and thus when such a feature is used to make a design such that an snp site to be detected is located at the 5′-end site of the probe, the 5′-flap formation is induced according to the allele, thereby allowing effective snp detection..
Genotech Corp.

Methods for multiplex detection of alleles associated with ophthalmic conditions

Systems and methods for detecting at least two genomic alleles associated with corneal dystrophy in a sample from a human subject are disclosed in which cells (e.g., epithelial) of the subject are adhered to a tip of a substrate. The tip of the substrate is agitated in a lysis solution that lyses cells adhered to the substrate.
Avellino Lab Usa, Inc.

Select single nucleotide polymorphisms predictive of response to glatiramer acetate

(iii) administering the pharmaceutical composition comprising glatiramer acetate and a pharmaceutically acceptable carrier to the subject only if the subject is identified as a predicted responder to glatiramer acetate.. .

Influence of genotype on susceptibility to treatment with fish oil

The present invention relates to methods for assessing an individual's susceptibility to treatment of an inflammatory disease with a dietary supplement. The invention describes the recognition that the sensitivity of an individual to the inflammation suppressing effects of fish oil on tnf-α production is linked both to genetic variation encoded by, or associated with, tnf-α, lt-α and/or il-6 single nucleotide polymorphisms and to the inherent level of production of tnf-α by cells..

Method for determining snp genotype

The present invention is generally drawn to a novel method for determining a snp (single nucleotide polymorphism) genotype using a pto-snv (probing and tagging oligonucleotide for single nucleotide variation). The present invention provides novel protocols for snp genotyping in which only one allele-specific oligonucleotide permits in a snp genotyping reaction to determine whether a target nucleic acid sequence to be analyzed is homozygous or heterozygous for the snp allele of interest or has no snp allele of interest..
Seegene, Inc.

Methods of treating heart failure with agonists of hypocretin receptor 2

Methods of treating individuals for heart failure are disclosed. In particular, the invention relates to methods of treating individuals for heart failure with agonists of hypocretin receptor 2.
The Board Of Trustees Of The Leland Stanford Junior University

Antipsychotic treatment based on snp genotype

The present invention relates to the prediction of antipsychotic treatment efficacy based on a patient's genotype at one or more single nucleotide polymorphism (snp) loci and to the treatment of a patient based on such prediction.. .
Vanda Pharmaceuticals, Inc.

Method for predicting clinical toxicity and outcome

A method for determining the sensitivity of a patient with cancer to receptor tyrosine kinase inhibitor therapy is provided. The method comprising screening a nucleic acid sample to determine the identity of at least one single nucleotide polymorphism (snp) genotype selected from the group consisting of rs1933437, rs1045642, rs1128503, rs2032582 and rs2231142 and any combination thereof; and determining the sensitivity of a patient with renal cancer to receptor tyrosine kinase inhibitor therapy based on the identity of the snp genotype.
Singapore Health Services Pte Ltd

Process and kit for predicting antibiotic resistance and susceptibility of bacteria

There is disclosed a pcr-based test kit and pcr process for identification of multiple clonal sub-species lineages of infectious bacteria, such as uropathogenic e. Coli causing cystitis, pyelonephritis and urosepsis, for the purposes of predicting antibiotic resistance of the bacteria.
Regents Of The University Of Washington

Detecting single nucleotide polymorphism using hydrolysis probes with 3' hairpin structure

Snp specific hydrolysis probe including a hairpin structure toward the 3′ end, along with kits are provided that are designed for the detection of a snp in a target nucleic acid. .
Roche Molecular Systems, Inc.

Method to predict heritable canine non-contact cruciate ligament rupture

Method and kits for diagnosing propensity to non-contact cranial cruciate ligament rupture (cclr) in a dog are described. The method includes isolating genomic dna from a dog and then analyzing the genomic dna from step for a single nucleotide polymorphism occurring in selected loci that have been determined to be associated with the cclr phenotype via a genome-wide association study..
Wisconsin Alumni Research Foundation

Major histocompatability coplex single nucleotide polymorphisms

The present disclosure relates to the identification of single nucleotide polymorphisms (snps) in the gamma genomic block in the central region of the major histocompatibility complex (mhc) that can be used for matching transplant donors and recipients and determining disease susceptibility.. .
Conexio Genomics Pty Ltd

Nucleotide transient binding for sequencing methods

Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (snp) analyses.
Life Technologies Corporation

Noninvasive prenatal diagnosis of fetal trisomy by allelic ratio analysis using targeted massively parallel sequencing

Whether a fetus has an aneuploidy associated with a first chromosome is detected using ratios of alleles detected in a maternal sample having a mixture of maternal and fetal dna. Dna from the sample is enriched for target regions associated with polymorphic loci and then sequenced.
The Chinese University Of Hong Kong

Nucleic acid amplification method using allele-specific reactive primer

The detection method using the allele-specific reactive primer (asrp) according to the present invention is a technique having a very high specificity of amplification due to the characteristics of the asrp and a proofreading dna polymerase. The detection method can effectively detect mutations (point mutation, insertion, deletion, etc.) including a single nucleotide polymorphism (snp), and can also be used to detect methylation of cpg after bisulfite treatment or to amplify and detect a target dna starting with a desired nucleotide sequence from a dna library..

Microrna polymorphisms conferring enhanced drought tolerance in a plant

Methods of identifying a single nucleotide polymorphism associated with a plant trait and methods of identifying a plant having an improved trait. The plant trait is correlated with at least one single nucleotide polymorphism in a microrna region of a plant genome.

Methods for measuring virulence in soybean cyst nematode

Phytoparasitic nematodes that are able to infect and reproduce on plants that are considered resistant are referred to as virulent. The mechanism(s) that virulent nematodes employ to evade or suppress host plant defenses are not well understood.

Fus/tls-based compounds and methods for diagnosis, treatment and prevention of amyotrophic lateral sclerosis and related motor neuron diseases

The invention provides novel fus/tls nucleic acids and proteins that comprise one or more genetic markers (for example, single nucleotide polymorphisms) and methods of use thereof including methods relating to the diagnosis of als or other related motor neuron disease by virtue of the presence of the mutant fus/tls sequence(s).. .

Antipsychotic treatment based on drd2 or ankk1 snp genotype

The present invention relates to the treatment of an individual with an antipsychotic based on individual's genotype at one or more single nucleotide polymorphism (snp) associated with the dopamine receptor d2 (drd2) and/or ankyrin repeat and kinase domain containing 1 (ankk1) genes.. .
Vanda Pharmaceuticals, Inc.

Neprilysin gene polymorphism and amyloid beta plaques in traumatic brain injury

The invention relates to methods of diagnosing risk of amyloid β deposition following traumatic brain injury. The invention further relates to the discovery of a specific single nucleotide polymorphism in the neprilysin gene that is linked to an increased risk of amyloid β deposition after traumatic brain injury..
The Trustees Of The University Of Pennsylvania

Markers to predict macrocyclic lactone drug resistance in dirofilaria immitis, the causative agent of heartworm disease

Disclosed are nucleic acid molecules from the genome of dirofilaria spp. Nematodes that contain single nucleotide polymorphisms related to reduced responsiveness of the nematodes to macrocyclic lactones.
Mcgill University

Microbial markers and uses therefor

Disclosed are methods for identifying and/or classifying microbes using one or more single nucleotide polymorphisms (snps) in 16s ribosomal rna (16s rrna) of prokaryotes and/or one or more snps in 5.8s ribosomal rna (5.8s rrna) of eukaryotes. Also disclosed are probes, primers and kits that are useful in those methods.
Immunexpress Pty Ltd

Strategies for high throughput identification and detection of polymorphisms

The invention relates to a method for the high throughput identification of single nucleotide polymorphisms by performing a complexity reduction on two or more samples to yield two or more libraries, sequencing at least part of the libraries, aligning the identified sequences and determining any putative single nucleotide polymorphisms, confirming any putative single nucleotide polymorphism, generating detection probes for the confirmed single nucleotide polymorphisms, subjection a test sample to the same complexity reduction to provide a test library and screen the test library for the presence or absence of the single nucleotide polymorphisms using the detection probe.. .
Keygene N.v.

Detecting single nucleotide polymorphism using overlapping hydrolysis probes

Methods for the rapid detection of the presence or absence of a snp in a target nucleic acid in a sample are described. The methods can include performing an amplifying step, a hybridizing step utilizing a double stranded probe with two overlapping snp specific hydrolysis probe sequences where one of the probe sequences can include a hairpin structure toward the 3′ end, and a detecting step.
Roche Molecular Systems, Inc.

Method for forming personal nutrition complex according to incidence of disease and genetic polymorphism by a prediction system

The present invention relates to a system for predicting an incidence of disease from genetic polymorphism and uses the prediction result to form a personal nutrition complex. The system collects at least one personal information and single nucleotide polymorphism (snp) information then exchanges the above information with databases including a personal database, a genetic risk database, an allelic frequency database, and a prevalence database.
Tci Gene, Inc.

Serotonin transporter gene and treatment of alcoholism

The gene responsible for encoding sert has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (l) and short (s). The ll-genotype is hypothesized to play a key role in the early onset of alcohol use.
University Of Virginia Patent Foundation

Methods and compositions for genetically detecting improved milk production traits in cattle

An isolated nucleic acid molecule comprising a polymorphic site selected from the group consisting of positions 164, 269, 284, 407 and 989 of seq id no: 1, an array or a kit comprising the same. Also provided are a method for detecting single nucleotide polymorphism (snp) in bovine proteinase inhibitor (pi) gene, a method for haplotyping a bovine cell, a method for progeny testing of cattle based on said haplotyping, a method for selectively breeding of cattle based on haplotyping a parent animal.
Wisconsin Alumni Research Foundation

Ligation-based detection of genetic variants

The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation, e.g., the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary to a region between the fixed sequence oligonucleotides—combined with detection of levels of particular genomic regions using array hybridization..

Genetic test to predict patient response to bone morphogenetic protein in arthrodesis

The present invention provides a method of predicting an increased likelihood of a complication associated with administration of a bone morphogenetic protein (bmp) to a subject in need of a spinal fusion surgery by detecting single nucleotide polymorphisms (snps) in the subject. Also provided are methods of treatment with a bmp based on the presence or absence of snps and kits for use in detecting the snps..
Orthopaedic Associates Of Michigan

Method for determining p1/p2 blood type and detection kit thereof

The present invention provides a method for determining p1/p2 blood type, including steps of providing a biological sample of a subject, detecting a genotype for single nucleotide polymorphism rs2143918 or rs5751348 in a4galt gene of the biological sample and determining a phenotype of the subject based on the genotype. Further, the present invention also provides a kit for determining p1/p2 blood type, including a primer pair for detecting a genotype for single nucleotide polymorphisms rs2143918 or rs5751348 in a4galt gene of a nucleic acid sample of a subject..

Soy gene cluster regions and methods of use

Methods for conveying pathogen resistance into non-resistant soybean germplasm are provided. In some embodiments, the methods include introgressing pathogen resistance into a non-resistant soybean using one or more nucleic acid markers for marker-assisted breeding among soybean lines to be used in a soybean breeding program, wherein the markers are linked to and/or associated with pathogen resistance.
Syngenta Participations Ag

Multiplexed sequential ligation-based detection of genetic variants

The present invention provides multiplexed sequential ligation-based analysis of genetic variants in a mixed sample, including copy number variations and single nucleotide polymorphisms. The invention employs the techniques of sequential ligation and amplification..
Ariosa Diagnostics, Inc.

Markers associated with soybean rust resistance and methods of use therefor

Methods for conveying soybean rust (sbr) resistance into non-resistant soybean germplasm are provided. In some embodiments, the methods include introgressing sbr resistance into a non-resistant soybean using one or more nucleic acid markers for marker-assisted breeding among soybean lines to be used in a soybean breeding program, wherein the markers are linked to and/or associated with sbr resistance.
Syngenta Participations Ag



Single Nucleotide Polymorphism topics:
  • Polymorphism
  • Single Nucleotide Polymorphism
  • Nucleotide
  • Nucleic Acid
  • Antibodies
  • Sequencing
  • Tocilizumab
  • Polynucleotide
  • Fluorouracil
  • Genetic Analysis
  • Polypeptide
  • Genetic Analysi
  • Carbohydrates
  • Microarray
  • Nucleic Acids


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    This listing is a sample listing of patent applications related to Single Nucleotide Polymorphism for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Single Nucleotide Polymorphism with additional patents listed. Browse our RSS directory or Search for other possible listings.


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