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Single Nucleotide Polymorphism

Single Nucleotide Polymorphism-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Genetic factors associated with inhibitor development in hemophilia a
January 18, 2018 - N°20180016635

The present invention provides methods for predicting the risk of an individual developing antibodies to factor viii by identifying a single nucleotide polymorphism of an immune response or immune modifier gene. The invention further provides oligonucleotides, diagnostic kits, microarrays, and isolated nucleic acids comprising single nucleotide polymorphisms of immune response or immune modifier genes.
Single nucleotide polymorphisms associated with bull fertility
Wisconsin Alumni Research Foundation
January 04, 2018 - N°20180002755

Single nucleotide polymorphic sites of the bovine map1b, ppp1r11, and ddx4 genes are associated with improved bull fertility as measured by e. G. Sire conception rates. Nucleic acid molecules, arrays, kits, methods of genotyping and marker-assisted bovine breeding methods based on these snps are disclosed.
Rapid quantitative detection of single nucleotide polymorphisms or somatic variants and methods to identify malignant ...
The General Hospital Corporation
December 28, 2017 - N°20170369939

Provided are systems, kits, and methods for the quantitative detection of single nucleotide polymorphisms or variants to identify malignant neoplasms. The methods include use of modified oligonucleotide blockers with peptide nucleic acid backbones that hybridize to and block logarithmic amplification of the wild-type alleles of a target, and incorporation of locked nucleic acids into probes that are complementary to a ...
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Pro-apoptotic anti-ng2/cspg4 antibodies and their uses for disease therapy
Universita' Degli Studi Di Parma
December 28, 2017 - N°20170369588

The present invention relates to an antibody capable of binding with high-affinity and high selectivity to the ectodomain of the transmembrane proteoglycan (pg) ng2/cspg4, preferably to discrete isoforms of said pg, preferably isoforms that may be generated by alternative splicing, and/or coding single nucleotide polymorphisms, and/or post-transcriptional and/or post-translational modifications. The invention further relates to an ...
Methods for treating or preventing cancer in a kras-variant patient and for diagnosing risk of ...
Mira Dx, Inc.
December 21, 2017 - N°20170360803

The invention relates to methods for preventing cancer in a kras-variant subject which include administering to the kras-variant subject an amount of estrogen effective to reduce the risk of developing cancer. In another aspect, the invention further relates to methods for treating cancer in a kras-variant subject, which include gradually decreasing estrogen exposure in the kras-variant subject to reduce the ...
Oligonucleotide probe for detecting single nucleotide polymorphism, and method for detecting single nucleotide polymorphism
Eiken Kagaku Kabushiki Kaisha
November 30, 2017 - N°20170342471

The present invention provides an oligonucleotide probe for single nucleotide polymorphism detection to be used for a target nucleic acid where a single nucleotide polymorphism is present, the oligonucleotide probe comprising a reporter region, an anchor region, and a linker region. The reporter region comprises: an oligonucleotide consisting of a sequence perfectly matching when a nucleotide of the single nucleotide ...
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Se33 mutations impacting genotype concordance
Life Technologies Corporation
November 23, 2017 - N°20170335377

Disclosed are primer set compositions, methods and kits for human identification using the highly complex sequence locus, se33 (actbp2) in single and multiplex pcr reactions. Additionally, disclosed are three newly discovered single nucleotide polymorphisms (snps) within the se33 locus that can cause discordance seen as mobility shift or allelic dropout. Also disclosed are kits useful in human identification.
Prediction of neonatal abstinence syndrome
Bournemouth University
November 16, 2017 - N°20170327892

A method for predicting the onset of neonatal abstinence syndrome is described. The method comprises detecting the presence or absence of two single nucleotide polymorphisms on the cyp2b6 gene. The use of a kit to effect the nas prediction method and a drug treatment regimen for nas neonates are also described.
Novel single nucleotide polymorphisms and community-associated methicillin-resistant staphylococcus aureus
November 02, 2017 - N°20170314065

The present invention is based on the discovery of novel polymorphisms (snps) in the penicillin binding protein (pbp3) gene in staphylococcus aureus. The presence of g88a and/or g2047a snps provides an accurate, reliable biomarker for the presence of methicillin resistant staphylococcus aureus (mrsa), specifically the community-associated mrsa (ca-mrsa). The present invention provides reagents used for detecting the ...
Computationally efficient correlation of genetic effects with function-valued traits
Microsoft Technology Licensing, Llc
October 05, 2017 - N°20170286593

This disclosure presents a model for identifying correlations in genome-wide association studies (gwas) with function-valued traits that provides increased power and computational efficiency by use of a gaussian process regression with radial basis function (rbf) kernels to model the function-valued traits and specialized factorizations to achieve speed. A gaussian process is assigned to each partition for each allele of a ...
Single nucleotide polymorphism (snp) markers for stevia
Purecircle Usa Inc.
October 05, 2017 - N°20170283819

Stevia varieties with high a content of rebd, a high content of rebm, and a high content of rebd and rebm containing various snp markers and ugt isoforms, are disclosed. Methods of screening for the snps are also disclosed as well as for using the snps in marker assisted breeding. Further provided are methods for introgressing the disclosed snps associated ...
Antibiotic resistance causation identification
Koninklijke Philips N.v.
September 21, 2017 - N°20170270244

Methods and systems for identifying causal genetic mechanisms of antibiotic resistance in pathogens. In accordance with at least one embodiment, the system includes a gene resistance module to identify genes present in an antibiotic resistant pathogen, a single nucleotide polymorphism module to identify mutations present in an antibiotic resistant pathogen, and an antibiotic resistance module configured to output the causation ...
Cell population analysis using single nucleotide polymorphisms from single cell transcriptomes
Fred Hutchinson Cancer Research Center
September 14, 2017 - N°20170260584

The disclosure provides methods and systems for producing single cell rna sequencing data. Single nucleotide polymorphisms (snps) identified in such data can be used to distinguish subpopulations of cells within a mixed population.
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Methods and compositions for treating a subject with a smad7 antisense oligonucleotide
Nogra Pharma Limited
August 24, 2017 - N°20170240893

The present invention relates to treatment of inflammatory bowel disease (e. G., crohn's disease and ulcerative colitis) using antisense nucleotides that are directed against polymorphic forms (e. G., those containing single nucleotide polymorphisms) of the smad7 mrna. The invention thus relates to treatment methods for subjects having polymorphic forms of smad7 and antisense oligonucleotides that specifically target smad7 mrna transcripts ...
Serotonin transporter gene and treatment of alcoholism
University Of Virginia Patent Foundation
August 10, 2017 - N°20170226585

The gene responsible for encoding sert has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (l) and short (s). The ll-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the l or short genotypes as ...
Site-specific endonuclease guided rolling circle amplification
Simply Diagnostics Inc.
July 27, 2017 - N°20170211137

The disclosure provides methods and kits involving site-specific endonuclease guided rolling circle amplification (rca). Nucleic acid substrates, optionally generated by hybridizing a guidance primer to a single stranded nucleic acid, are cleaved with a site-specific endonuclease. In the presence of the target site, endonuclease cleavage of the substrate generates a nucleic acid having a free 3′-hydroxyl end, which is ...
Method of characterizing sequences from genetic material samples
The Translational Genomics Research Institute
July 20, 2017 - N°20170206311

Among other aspects provided herein is a method describing the use of single nucleotide polymorphism (snp) genotyping microarrays to resolve whether genetic material (such as genomic dna) derived from a particular individual is present in a genetic material mixture (such as a complex genomic dna mixture) is disclosed. Furthermore, it is demonstrated that the identification of the presence of genetic ...
Microrna polymorphisms conferring enhanced drought tolerance in a plant
Syngenta Participations Ag
July 20, 2017 - N°20170204476

Methods of identifying a single nucleotide polymorphism associated with a plant trait and methods of identifying a plant having an improved trait. The plant trait is correlated with at least one single nucleotide polymorphism in a microrna region of a plant genome. Isolated nucleic acids, transgenic plants, and methods of producing the same are also disclosed.
Bulk allele discrimination assay
General Mills, Inc.
July 20, 2017 - N°20170204474

A method is described for bulk allele discrimination of multiple single nucleotide polymorphisms in multiple individuals. Also described is a kit for use in performing a method for bulk allele discrimination of multiple single nucleotide polymorphisms in multiple individuals.
Method for predicting risk of ankylosing spondylitis using dna copy number variants
Catholic University Industry Academic Cooperation Foundation
July 20, 2017 - N°20170204463

The present invention relates to a method of predicting the risk of developing ankylosing spondylitis using dna copy number variation. It was verified that the risk of developing ankylosing spondylitis can be effectively predicted using primers for detecting dna copy number variation, of the present invention, and the sensitivity and specificity of prediction can be improved by grafting the results ...
Method for prediction of fetal monogenic genetic variations using maternal serum dna
Sk Telecom Co., Ltd.
July 13, 2017 - N°20170198348

The present invention provides a method for non-invasively detecting, expecting, or diagnosing fetal single nucleotide polymorphisms and the resultant monogenic disorders, through maternal cell-free dna sequencing. The diagnosis method according to the present invention does not harm mothers or fetuses and is convenient, in that analysis is possible using maternal blood samples; and can be favorably used for a prenatal ...
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