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Scaffold patents

      

This page is updated frequently with new Scaffold-related patent applications.




 Scaffold data storage and target detection in a sample using a nanopore patent thumbnailScaffold data storage and target detection in a sample using a nanopore
Provided are methods and compositions for detecting a target analyte suspected to be present in a sample with background molecules using a nanopore device. A plurality of probes for polymer scaffold identification or for target analyte binding and detection are provided.
Two Pore Guys, Inc.


 A container for framework elements patent thumbnailA container for framework elements
The present invention relates to a container for parts of a shoring or scaffold system, the container comprising at least one mounting point for at least a part of the scaffold system, wherein in use, when the part is in its in use position, at least a portion of the part is engageable with the mount, and when the part is not in use, the container is adapted to carry the part. In use, the container is multipurpose, in that it is adapted to carry scaffold parts, or serve as a platform for the scaffold parts, or serve as a platform for the scaffold.
Form 700 Pty Ltd


 Regeneration of a functional pulmonary vascular bed patent thumbnailRegeneration of a functional pulmonary vascular bed
A method for vascular regeneration comprises delivering endothelial cells to a lung scaffold, delivering perivascular cells to the lung scaffold, and providing a multiphase culture program to the scaffold. The multiphase culture program comprises a first phase including delivering an angiogenic medium, e.g., having 40-100 ng/ml of pro-angiogenic factors, and a second phase including delivering a stabilization medium, e.g., having 0.5-2% of serum and 1-20 ng/ml of angiogenic factors..
The General Hospital Corporation


 Methods of selective cell attachment/detachment, cell patternization and cell harvesting by means of near infrared rays patent thumbnailMethods of selective cell attachment/detachment, cell patternization and cell harvesting by means of near infrared rays
The present invention relates to a method for selective cell attachment/detachment, cell patternization and cell harvesting by means of near infrared rays. More particularly, conducting polymers or metal oxides having exothermic characteristics upon irradiation of near infrared light is used as a cell culture scaffold, thus selectively attaching/detaching cells without an enzyme treatment.
Industry-academic Cooperation Foundation, Yonsei University


 Methods and systems for selectively disrupting tissue with high intensity focused ultrasound patent thumbnailMethods and systems for selectively disrupting tissue with high intensity focused ultrasound
Methods and systems for selectively disrupting tissue using high intensity focused ultrasound (“hifu”) therapy are disclosed herein. A method of treating tissue in accordance with an embodiment of the present technology can include, for example, pulsing hifu waves from an ultrasound source toward a volume of tissue that includes an extracellular matrix (“ecm”) and generating, from nonlinear propagation of the hifu waves, shock waves in the tissue to induce boiling in the volume of the tissue.
University Of Washington


 Scaffolds comprising nanoelectronic components for cells, tissues, and other applications patent thumbnailScaffolds comprising nanoelectronic components for cells, tissues, and other applications
The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold.
Children's Medical Center Corporation


 Electrospinning with sacrificial template for patterning fibrous constructs patent thumbnailElectrospinning with sacrificial template for patterning fibrous constructs
Methods are disclosed which combine electrospinning and a sacrificial template, such as with additive manufacturing (am), to produce fibrous microvascular scaffolds which are biodegradable, porous, and easily handled. In one example, a process for fabricating a fibrous network construct is disclosed.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education


 Bone grafts including osteogenic stem cells, and methods relating to the same patent thumbnailBone grafts including osteogenic stem cells, and methods relating to the same
Bone grafts and constructs including stem cells are provided. Example bone grafts include osteogenic stem cells seeded on a scaffold of osteoconductive cortico-cancellous chips and/or osteoinductive demineralized bone.
Globus Medical, Inc.


 Hydrogel including surface-treated nanofiber and preparation method thereof patent thumbnailHydrogel including surface-treated nanofiber and preparation method thereof
Provided are a bioadhesive hydrogel including surface-treated nanofibers, a preparation method thereof, and use of thereof. The hydrogel including surface-treated nanofibers provided in the present invention may have excellent bioadhesive strength, thereby being widely applied to a bioadhesive, a scaffold for tissue engineering, a carrier for drug delivery, etc..
Postech Academy-industry Foundation


 A composition comprising ex-vivo generated dendritic cells patent thumbnailA composition comprising ex-vivo generated dendritic cells
The present invention relates to a composition comprising ex-vivo generated antigen-loaded dendritic cells in combination with β-glucan and hyaluronic acid or pharmaceutically acceptable derivatives thereof and methods of preparing and delivering the same. The present composition of the present invention enhances antigen-specific t cell response against cancer cells.

Methods and systems for scaffolds comprising nanoelectronic components

The present invention generally relates to nanoscale wires and tissue engineering. Systems and methods are provided in various embodiments for preparing cell scaffolds that can be used for growing cells or tissues, where the cell scaffolds comprise nanoscale wires.
President And Fellows Of Harvard College

Data driven framework for optimizing artificial organ printing and scaffold selection for regenerative medicine

A method for generating a personalized scaffold for an individual includes acquiring images of an anatomy of interest corresponding to an intended scaffold location and acquiring test results related to the anatomy of interest. One or more functional specifications are generated based on the images and test results and one or more scaffold parameters are selected based on the functional specifications.
Siemens Healthcare Gmbh

Compositions and methods utilizing lysophosphatidylcholine scaffolds

The invention relates to compositions and methods for utilizing lysophosphatidylcholine scaffolds. The compositions and methods can be used for lpc-mediated delivery of fatty acids and other molecules; to screen and identify fatty acid formulations for parenteral nutrition; and for live animal organ imaging, among other uses.
National University Of Singapore

Peptide libraries

The invention relates to a method for altering the conformational diversity of a first repertoire of polypeptide ligands, comprising a plurality of polypeptides comprising at least two reactive groups separated by a loop sequence covalently linked to a molecular scaffold which forms covalent bonds with said reactive groups, to produce a second repertoire of polypeptide ligands, comprising assembling said second repertoire from the polypeptides and structural scaffold of said first repertoire, incorporating one of the following alterations: (a) altering at least one reactive group; or (b) altering the nature of the molecular scaffold; or (c) altering the bond between at least one reactive group and the molecular scaffold; or (d) any combination of (a), (b) or (c).. .
Bicycle Therapeutics Limited

Dna gridiron compositions and methods

Novel compositions and methods for engineering wireframe architectures and scaffolds of increasing complexity by creating gridiron-like dna structures (fig. 1).
Arizona Board Of Regents On Behalf Of Arizona Stat E University

Synthetic cornea from retinal stem cells

Methods of producing synthetic corneas are disclosed which are differentiated from retinal stem cells (rsc) derived from parthenogenetically activated human oocytes, including that such synthetic corneas are produced in the absence of a 3-d scaffold. Isolated synthetic corneas, produced by the disclosed methods, are also described..
International Stem Cell Corporation

Lipoprotein nanoplatelets: fluorescent, zwitterionic probes for molecular and cellular imaging

Compositions are provided comprising water-stable semi-conductor nanoplatelets encapsulated in a hydrophilic coating further comprising lipids and lipoproteins. Uses include biomolecular imaging and sensing, and methods of making comprise: colloidal synthesis of cdse core npls; layer-by-layer growth of a cds shell; and encapsulation of cdse/cdscore/shell npls in lipid and lipoprotein components through an evaporation-encapsulation using zwitterionic phospholipids, detergents, and amphipathic membrane scaffold proteins..
The Board Of Trustees Of The University Of Illinois

Stabilized rope ladder

This invention relates to a stabilized rope ladder comprising stabilizing steps that are lengthwise extensions of normal rope ladder steps and which further comprise a strength-enhancing metal scaffold enclosed in a polymeric composition.. .

Process of increasing energy conversion and electrochemical efficiency of a scaffold material using a deposition material

A process for increasing the energy conversion and electrochemical efficiency of a scaffold material using a deposition material comprises flowing by at least one surface of the scaffold material a solution which comprises the deposition material, forming agglomerations of the deposition material with at least one surface of the scaffold material, wherein the deposition material fills pores on the at least one surface of the scaffold material (“scaffold pores”) thereby increasing the surface area of the scaffold material, electrically connecting deposition material to the scaffold material via the formation of agglomerations, wherein said scaffold material is conductive and flow-through and wherein deposition material has a pore size (“deposition material pore size”) which is no larger than the scaffold pore size.. .
Simon Fraser University

Self-assembled beta solenoid protein scaffolds

The present invention provides amyloid fibrils comprising a plurality of modified β solenoid protein (mbsp) monomers. The mbsp monomers are modified to enhance self-assembly and are useful in a variety of applications..
The Regents Of The University Of California

Personalized creation from medical imaging

In personalized object creation, for implants, medical imaging is used to derive a model personalized to a patient. The model may be of a dynamic structure, such as part of the cardiovascular system, and is used to print the implant itself.
Siemens Medical Solutions Usa, Inc.

Implant comprising fgf-18

The invention relates to the field of pharmaceutical compositions. More particularly it is directed to substance delivery system (or implant), such as scaffolds and membranes, comprising an anabolic drug, such as a fibroblast growth factor 18 (fgf-18) compound, to methods of producing such delivery system, as well as use thereof.
Merck Patent Gmbh

Three-dimensional silk fibroin scaffold culture retaining functional salivary cells and promoting salivary tissue-specific ecm synthesis

A cell culture system including a silk fibroid scaffold, culture media, and salivary gland cells. The salivary gland cells grown in the tissue culture system have physiological and morphological features like those of in vivo salivary gland cells.
The Board Of Regents Of The University Of Texas System

Sophorolipid mediated accelerated gelation of silk fibroin

The present invention provides a biocompatible hydrogel composition comprising glycolipids and silk fibroin (sf) wherein glycolipid is preferably sophorolipids (sl). The said composition is useful in preparation of 3d scaffold for use in tissue engineering, and in the biomedical field.
Council Of Scientific & Industrial Research

Lyophilized polymer scaffold compositions, processes for preparation and use in anabolic wound repair

The present application relates to a lyophilized scaffold composition having at least one polysaccharide wherein said scaffold is substantially solid and capable of being formed into a desired shape; wherein the at least one polysaccharide has a protonation level resulting in controlled rehydration of said scaffold, such that when said scaffold is contacted with at least one of a neutral aqueous solution, blood, blood derived fluid and combinations thereof, said scaffold forms a microparticle dispersion and stimulates tissue remodeling and anabolic wound repair, a process for preparing a lyophilized scaffold composition and the use of a lyophilized scaffold composition for wound repair in a mammal.. .
Ortho Regenerative Technologies Inc.

Polymer nanofiber scaffolds and uses thereof

A polymer nanofiber scaffold includes a plurality of melt extruded nanofibers that are chemically modified to append surface functionality to the nanofibers.. .
Case Western Reserve University

Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer.
Immatics Biotechnologies Gmbh

Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer.
Immatics Biotechnologies Gmbh

Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer.
Immatics Biotechnologies Gmbh

Novel droplet-embedded microfibers, and methods and devices for preparing and using same

The invention includes microfluidic methods and devices that allow for the continuous production of microfibers with embedded droplets aligned along the length of the fiber at specific positions. The invention allows for formation of single or multiple emulsions within a fiber.
The Trustees Of Princeton University

System and conditioning an endoprosthesis

An endoprosthesis is conditioned prior to use within a patient by placing a scaffold of the endoprosthesis in contact with a sterile liquid optionally at body temperature, following by causing the scaffold to bend. The scaffold may be bent by moving the scaffold through a conditioning tube..
Abbott Cardiovascular Systems Inc.

Prosthetic valve system having a docking component and a prosthetic valve component

A two-component valve prosthesis system includes a docking component and a prosthetic valve component that is configured to be delivered separately from the docking component. The docking component has a compressed configuration for percutaneous delivery within a vasculature and an expanded configuration for deployment within a native heart valve.
Medtronic Vascular, Inc.

Engineered floor and scaffold systems

This unique modular flooring system with system scaffold understructure is an engineered system capable of use with most tent manufacturer's options. The engineered floor is for engineered clear span tents.
Biljax Inc.

System and a piezoelectric scaffold for nerve growth and repair

Provided is an electroactive structure for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a biocompatible synthetic piezoelectric polymeric material, wherein the matrix of fibers is seeded with the isolated differentiable cells and forms a supporting scaffold for growing the isolated differentiable cells, and wherein the matrix of fibers stimulates differentiation of the isolated differentiable cells into a mature cell phenotype on the structure.. .
New Jersey Institute Of Technology

Certain chemical entities, compositions, and methods

Chemical entities that are effective as kinase inhibitors, pharmaceutical compositions and methods of treatment are disclosed. The chemical entities disclosed specifically inhibit signal transduction and cellular proliferation by modulating the activity of protein kinases to regulate and modulate abnormal or inappropriate cell proliferation, differentiation, or metabolism.
Neupharma, Inc.

Novel low molecular weight cationic lipids for oligonucleotide delivery

The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and peg-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver.
Sirna Therapeutics, Inc.

Printed scaffold structure for hybrid composites

The present invention provides a 3-d printed scaffold tailored to a particular hybrid composite material to receive the reinforcement components and support them during application of a secondary composite material. The printed scaffold may provide for retention features that locate and hold the reinforcement components in a variety of different configurations and may incorporate a microstructure having vacuum diffusion properties to assist in composite material lay-up.

Fiber reinforced hydrogels and methods of making same

Disclosed herein are biomaterials that include a plurality of fibers embedded in a matrix of hydrogel material. The plurality of fibers and hydrogel material are formed during one process step.
Case Western Reserve University

Header core fixation design for an imd

Aspects of the present disclosure are directed toward apparatuses, systems, and methods that may comprise a medical device having a header, a core assembly, and a scaffold assembly. The scaffold assembly may be configured to interface with the core assembly and position and support one or more circuit component relative to one or more other circuit components..
Cardiac Pacemakers, Inc.

Biocompatible scaffolds with tissue fragments

A biocompatible tissue repair implant or scaffold device is provided for use in repairing a variety of tissue injuries, particularly injuries to cartilage, ligaments, tendons, and nerves. The repair procedures may be conducted with implants that contain a biological component that assists in healing or tissue repair.
Depuy Mitek, Llc

Natural tissue scaffolds as tissue fillers

Tissue fillers derived from decellularized tissues are provided. The tissue fillers can include acellular tissue matrices that have reduced inflammatory responses when implanted in a body.
Lifecell Corporation

Bioresorbable ceramic composition for forming a three dimensional scaffold

The present disclosure is directed to a bioresorbable ceramic composition having a plurality of biocompatible ceramic granules, each of the granules having a coating of a plurality of calcium containing particles, where at least a portion of the particles are bound to at least a portion of an outer surface of each of the granules, and further where the composition is flowable in a dry state. The present disclosure is also directed to a three dimensional scaffold for bone repair that includes the bioresorbable composition, which upon implantation to a locus of repair defines an interconnected pore network between outer walls of the coated granules of the composition.
Depuy Synthes Products, Inc.

Homomultivalent and heteromultivalent inhibitors of prostate specific membrane antigen (psma) and uses thereof

The present invention provides bivalent and multivalent ligands with a view to improving the affinity and pharmacokinetic properties of a urea class of psma inhibitors. The compounds and their synthesis can be generalized to multivalent compounds of other target antigens.
The Johns Hopkins University

Methods for maintaining pegylation of polypeptides

Described herein are methods for maintaining pegylation and inhibiting depegylation of polypeptides, such as fibronectin-based scaffold proteins, during storage.. .
Bristol-myers Squibb Company

Method to increase radial strength of a bioresorbable scaffold

Methods of fabricating a polymer scaffold with increased radial strength including steps of elongation or strain of a biaxially oriented tube and annealing or thermal processing of the strained tube at a constant strain are disclosed. The steps of elongation and thermal processing increase axial direction chain orientation and lamellar crystal growth, increase radial strength, and decrease the thickness of the tube.
Abbott Cardiovascular Systems Inc.

Scaffolds having variable wall thickness

A scaffold strut is shaped to improve hemocompatibility. The scaffold is made from a tube having variable wall thickness.
Abbott Cardiovascular Systems Inc.

Active-ester-group-containing composition for producing fibers, and cell culture scaffold material using fibers produced from active-ester-group-containing composition

Wherein each symbol in the formulas (1) and (2) is as described in the description.. .

Foamed polyurethane polymers for the regeneration of connective tissue

The present invention relates to a method of synthesis and the use of foamed, cross-linked polyurethane polymers, as a three-dimensional support called a “scaffold” for cell cultures in vitro and for in vivo implantation for the regeneration of connective tissues such as adipose tissue, osteochondral tissue and bone tissue. In particular, the invention relates to a method of preparing polymers or foamed polyurethane co polymers, having improved hydrophilia, which involves the use of two types of catalyst, one for the cross-linking reaction and one for the foaming reaction and the use of at least one polar aprotic high-boiling solvent.
Tensive S.r.l.

Engineering of immunoglobulin domains

The present invention provides a single domain antibody (sdab) scaffold comprising one or more than one non-canonical disulfide bond in the framework region (fr). The one or more than one non-canonical disulfide bond may be formed between cysteines introduced by mutations in fr2 and fr3.
National Research Council Of Canada

Methods of manufacturing bioactive gels from extracellular matrix material

The present invention is directed to methods of manufacturing bioactive gels from ecm material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction, the manufacturing methods take advantage of a new recognition that bioactive gels from ecm material can be created by digesting particularized ecm material in an alkaline environment and neutralizing to provide bioactive gels.. .
Acell, Inc.

Methods for forming scaffolds

A method of forming a scaffold is disclosed herein. In some embodiments, a method of forming a scaffold includes dissolving a polymer in a solvent to form a polymer solution; adding additive precipitating agent to the polymer solution; precipitating and expanding the polymer from the polymer solution to form a scaffold; and removing the solvent from the scaffold.
Howmedica Osteonics Corp.



Scaffold topics:
  • Nucleotide
  • Recombinant
  • Polynucleotide
  • Amino Acid
  • Biodegradable
  • Encapsulation
  • Surfactant
  • Enhancement
  • Monoclonal Antibody
  • Polypeptide
  • Immunogenic
  • Amino Acid Sequence
  • Monoclonal
  • Interleukin 2
  • Immune Disease


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    This listing is a sample listing of patent applications related to Scaffold for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Scaffold with additional patents listed. Browse our RSS directory or Search for other possible listings.


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