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Scaffold-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

NEW Polynucleotide construct capable of displaying fab in a cell-free translation system, and method for manufacturing ...
The University Of Tokyo
January 18, 2018 - N°20180017573

The polynucleotide construct of (1) or (2) below is used to perform ribosome display, cis display and/or mrna display in order to screen a fab against an antigen of interest: (1) a polynucleotide construct which monocistronically comprises a ribosome-binding sequence, fab first chain-coding sequence, linker peptide-coding sequence, fab second chain-coding sequence and scaffold-coding sequence in this order, and further comprises at its 3&#...
NEW Backbone mediated mate pair sequencing
Keygene N.v.
January 18, 2018 - N°20180016631

Disclosed is a method suitable for (long-range) mate pair sequencing wherein the mate pairs are located within a certain distance from each other on the same nucleotide sequence. By ligating a dna fragment into an identifier section—containing backbone, a digestable circularized construct is provided to which adaptors can be ligated after digestion. Amplification yields amplicons that contain a ...
NEW Self-aligned fibrous scaffolds for automechanoinduction of cell cultures
Tallinn University Of Technology
January 18, 2018 - N°20180016551

Self-aligned fibrous scaffolds are disclosed. The scaffolds are capable of automechanoinduction of cell cultures and methods to induce authomechanoinduction in cancer cells and stem cells are disclosed as well.
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NEW Stable heterodimeric antibody design with mutations in the fc domain
Zymeworks Inc.
January 18, 2018 - N°20180016347

The provided scaffolds have heavy chains that are asymmetric in the various domains (e. G. Ch2 and ch3) to accomplish selectivity between the various fc receptors involved in modulating effector function, beyond those achievable with a natural homodimeric (symmetric) fc molecule, and increased stability and purity of the resulting variant fc heterodimers. These novel molecules comprise complexes of heterogeneous components ...
NEW Smart release system for growth factor delivery and combined bone and vascular growth
The George Washington University A Congressionally Chartered Not-for-profit Corporation
January 18, 2018 - N°20180015207

Embodiments of the present invention relate to structures and systems having a three-dimensional biomimetic structure with a porous biomimetic three-dimensional scaffold and a coating deposited onto a surface of the porous biomimetic three-dimensional scaffold as well as methods of using and fabricating the like.
NEW Electrospun three-dimensional nanofibrous scaffolds with interconnected and hierarchically structured pores
South Dakota Board Of Regents
January 18, 2018 - N°20180015201

The invention relates to electrospun three-dimensional (3d) nanofibrous scaffolds (with controllable porosities as high as about 96%) and methods of preparing the same. The electrospun 3d scaffolds possess interconnected and hierarchically structured pores with sizes ranging from tens of nanometers to hundreds of micrometers. In embodiments, the 3d scaffolds can be biocompatible and/or biodegradable. In some embodiments, the 3d scaffolds ...
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NEW Lactate dehydrogenase inhibitor and antiepileptic drug containing the same
National University Corporation Okayama University
January 18, 2018 - N°20180015068

The invention provides a lactate dehydrogenase inhibitor that makes it possible to suppress refractory epilepsy in which conventional antiepileptic drugs are ineffective, and an antiepileptic drug containing said inhibitor. The lactate dehydrogenase inhibitor of the invention contains a compound represented by formula (iii); i. E., isosafrole or a compound having isosafrole as a scaffold, and the antiepileptic drug of the ...
Aluminized metallic scaffold for high temperature applications and method of making an aluminized metallic scaffold
The Board Of Trustees Of The University Of Illinois
January 11, 2018 - N°20180010257

An aluminized metallic scaffold for high temperature applications comprises a porous non-refractory alloy structure including a network of interconnected pores extending therethrough. The porous non-refractory alloy structure comprises a transition metal phase and an aluminide phase, and portions of the porous non-refractory alloy structure between interconnected pores have a thickness no greater than about 500 nm. A method of making an ...
Hydrogel comprising a scaffold macromer crosslinked with a peptide and a recognition motif
Massachusetts Institute Of Technology
January 11, 2018 - N°20180010091

Methods of forming, dissolving, and functionalizing an extracellular matrix gel on demand based on cross-linking, modification, and dissolution of hydrogels using transpeptidase (e. G. Sortase) are disclosed. Also provided are hydrogels comprising one or more macromers crosslinked to a mixture of peptides, wherein all or a portion of the peptides in the mixture comprise a recognition motif cleavable by a ...
Photon enhanced biological scaffolding
Massachusetts Institute Of Technology
January 11, 2018 - N°20180008836

Provided herein are biocompatible scaffolds engineered to convey growth stimulatory light to cells and augment their growth on the scaffolds both in vitro and in vivo. Also provide are methods of modifying biocompatible transparent waveguides to control delivery of light from the waveguide material.
Bone tissue engineering by ex vivo stem cells ongrowth into three-dimensional trabecular metal
Zimmer Trabecular Metal Technology, Inc.
January 11, 2018 - N°20180008747

Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant ...
Surgical sutures incorporated with stem cells or other bioactive materials
Bioactive Surgical, Inc.
January 11, 2018 - N°20180008744

Materials and methods for immobilizing bioactive molecules, stem and other precursor cells, and other agents of therapeutic value in surgical sutures and other tissue scaffold devices are described herein. Broadly drawn to the integration and incorporation of bioactive materials into suture constructs, tissue scaffolds and medical devices, the present invention has particular utility in the development of novel systems that ...
Scaffold-seeded oral mucosa stem cells
Technion Research & Development Foundation Limited
January 11, 2018 - N°20180008648

A method of treating a spinal cord injury in a subject in need thereof is disclosed. The method comprises implanting a scaffold into the spinal cord of a subject, wherein the scaffold is seeded with oral mucosa stem cells (omsc) and/or cells that have been ex vivo differentiated from said omscs, thereby treating the spinal cord injury.
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Thermal processing of polymer scaffolds
Abbott Cardiovascular Systems Inc.
January 11, 2018 - N°20180008438

Methods are disclosed including thermally processing a scaffold to increase the radial strength of the scaffold when the scaffold is deployed from a crimped state to a deployed state such as a nominal deployment diameter. The thermal processing may further maintain or increase the expansion capability of the scaffold when expanded beyond the nominal diameter.
Scaffold for alloprosthetic composite implant
Mako Surgical Corp.
January 11, 2018 - N°20180008418

An alloprosthetic composite implant comprising includes a structural porous scaffold having a pore density profile corresponding to a density profile of bone to be replaced. A plurality of cells are seeded within pores of the porous scaffold and grown by incubation. The cells may include osteoblasts and/or stem cells to form the structure of the implant, and one or ...
Method for learning to read using specialized text
Mako Surgical Corp.
January 04, 2018 - N°20180005543

A method of providing an instructional scaffold to person learning to read english language comprises displaying printed matter to the learner in the form of lists. Preferably text stories. The normal spacing of the letters in words is kept intact; in a first part of the method the rime portions of monosyllable words are bolded and made larger than the ...
Methods and materials for assembling nucleic acid constructs
Mayo Foundation For Medical Education And Research
January 04, 2018 - N°20180002707

This document provides methods and materials for assembling nucleic acid constructs (e. G., talens). For example, methods for assembling tales that are rapid, flexible for use in many cloning scaffolds (such as common nuclease and nickase backbones), and achievable with standard molecular biology laboratory tools, thereby making tales a more accessible genome system, are provided.
Omentum based scaffold and delivery system
Ramot At Tel-aviv University Ltd.
January 04, 2018 - N°20180000990

Compositions of matter comprising decellularized omentum are disclosed. The compositions may be scaffolds, hydrogels or hydrogel precursor compositions. Methods of generating the compositions are disclosed as well as uses thereof.
Method of fabricating scaffold for tissue engineering
Gc Corporation
January 04, 2018 - N°20180000988

A method of fabricating a scaffold for tissue engineering that includes a frame structure including one of poly-d-lactic acid and poly-l-lactic acid and a coating layer formed on a surface of the frame structure and including a lactic acid-glycolic acid copolymer. The method includes mixing a first granular porous substance including one of poly-d-lactic acid and poly-l-lactic acid with a ...
Novel low molecular weight cationic lipids for oligonucleotide delivery
Sirna Therapeutics, Inc.
January 04, 2018 - N°20180000939

The instant invention provides for novel catiome lipids that can be used in combination with other lipid components such as cholesterol and peg-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in ...
Alkaloids from sponge, scaffolds for the inhibition of human immunodeficiency virus (hiv)
King Abdullah University Of Science And Technology
January 04, 2018 - N°20180000787

Anti-viral compounds with low cytotoxicity are identified from screening of products found in red sea sponges, including the sponge stylissa carteri. The identified compounds can be brominated pyrrole-2-aminoimidazole alkaloids and derivatives thereof. Specific examples of identified compounds include oroidin, hymenialdisine, and debromohymenialdisine, as well as derivatives thereof. The compounds also can be useful scaffolds or pharmacores for further chemical ...