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Scaffold

Scaffold-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Stabilized and autonomous antibody vh domain
Nanyang Technological University
November 09, 2017 - N°20170320934

The present invention relates to single domain antibodies comprising at least one modification relative to the 4d5 antibody scaffold or human germline vh3 domain, the modifications selected from the group consisting of h35d, a78v, s93v, s93g and w103r, with the position numbering being according to the kabat numbering scheme. Disulfide-free variants further comprise at least ...
Composite polymeric nanofibers for skin regeneration
Nanyang Technological University
November 09, 2017 - N°20170319744

A method for preparing a skin regeneration scaffold is disclosed. The method may include preparing a polymer solution by dissolving a biopolymer in a solvent, and subjecting the polymer solution to a template-assisted extrusion process with a nanoporous material as a template in order to produce polymer nanofibers. Furthermore, the method includes fabricating a multilayer composite nanofibrous scaffold using the ...
Alimentary protein-based scaffolds (aps) for wound healing, regenerative medicine and drug discovery
Drexel University
November 09, 2017 - N°20170319743

The invention provides engineered biomaterials derived from plant products. The engineered biomaterials are useful for biomedical applications. The engineered biomaterials are able to support the growth of animal calls.
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Porous polysaccharide scaffold comprising nano-hydroxyapatite and use for bone formation
Universite Paris Diderot - Paris 7
November 09, 2017 - N°20170319741

The present invention relate to three dimensional porous polysaccharide matrices able to induce mineralisation of a tissue in osseous site, as well as in non-osseous site, in the absence of stem cells or growth factors.
High molecular weight polylactide and polycaprolactone copolymer and blends for bioresorbable vascular scaffolds
Abbott Cardiovascular Systems Inc.
November 09, 2017 - N°20170319363

Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having a high molecular weight polymer, thin struts in a selected range and sufficient radial strength to support a vessel upon deployment. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction ...
Systems and methods for producing gastrointestinal tissues at an anstomosis or other physiological location
Biostage, Inc.
November 09, 2017 - N°20170319325

Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e. G., esophageal tissue).
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Scaffold Patent Applications
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  • 470+ full patent PDF documents of Scaffold-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Method of manufacturing pancreas islet of langerhans mimics using induced pluripotent human stem cells
Biostage, Inc.
November 02, 2017 - N°20170313987

The present disclosure provides a method of manufacturing pancreas islet of langerhans (iol) mimetics using induced human pluripotent stem cells (ipsc) and porous micro carrier scaffolds that allow for subsequent vascularization and/or innervation.
Novel chimeric antigen receptors
Biostage, Inc.
November 02, 2017 - N°20170313759

The invention relates to chimeric antigen receptor (car) scaffolds comprising: a target binding domain; a spacer region; a transmembrane domain; and an intracellular effector domain, wherein the spacer region comprises at least one, or multiples of, domains 2, 3 or 4 or a combination thereof of a cd4 molecule. The invention also relates to polynucleotides and expression vectors encoding said car scaffold and ...
Nanoporous metal-carbon composite
Biostage, Inc.
November 02, 2017 - N°20170312725

Described here is a metal-carbon composite, comprising (a) a porous three-dimensional scaffold comprising one or more of carbon nanotubes, graphene and graphene oxide, and (b) metal nanoparticles disposed on said porous scaffold, wherein the metal-carbon composite has a density of 1 g/cm3 or less, and wherein the metal nanoparticles account for 1 wt. % or more of the metal-carbon composite. Also described ...
Compositions for regenerating defective or absent myocardium
Biostage, Inc.
November 02, 2017 - N°20170312394

Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
Double-structured tissue implant and a method for preparation and use thereof
Biostage, Inc.
November 02, 2017 - N°20170312391

A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit. A process for preparation ...
Protective sheath assembly for a polymer scaffold
Biostage, Inc.
November 02, 2017 - N°20170312110

A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. A sheath is placed over the crimped scaffold after crimping to reduce recoil of the crimped polymer scaffold and maintain scaffold-balloon engagement relied on to hold the scaffold to the balloon when the scaffold is being delivered to a target in a body. The sheath ...
Biodegradable supporting device
Biostage, Inc.
November 02, 2017 - N°20170312102

A biodegradable in vivo supporting device is disclosed. In one embodiment, a coated stent device includes a biodegradable metal alloy scaffold made from a magnesium alloy, iron alloy, zinc alloy, or combination thereof, and the metal scaffold comprises a plurality of metal struts. The metal struts are at least partially covered with a biodegradable polymer coating. A method for making ...
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Scaffold Patent Applications
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  • 470+ full patent PDF documents of Scaffold-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
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Bioactive soft tissue implant and methods of manufacture and use thereof
Biostage, Inc.
November 02, 2017 - N°20170312080

A bioactive filamentary structure includes a sheath coated with a mixture of synthetic bone graft particles and a polymer solution forming a scaffold structure. In forming such a structure, synthetic bone graft particles and a polymer solution are applied around a filamentary structure. A polymer is precipitated from the polymer solution such that the synthetic bone graft particles and the ...
Systems and methods for managing a patient
Biostage, Inc.
November 02, 2017 - N°20170311926

Implementations described and claimed herein provide systems and methods for managing one or more patients. In one implementation, an imaging window is determined based on a location of a probe. A primary image cross-section for the imaging window is identified for the imaging window. At least one image is generated along the primary image cross-section using patient data captured using ...
Microchannel scaffolds and microtube electrodes for a neural interface system
Biostage, Inc.
November 02, 2017 - N°20170311827

Neural interfaces with the peripheral nervous system have been developed to provide a direct communication pathway between peripheral nerves and prosthetic limbs. Described herein is a microchannel integrated neural network device and system which can control the reinnervated muscles and interpret neurological signals. The acquired bioelectrical signals can be used for the interpretation of mind and create a neural map.
Biology based techniques for handling information security and privacy
International Business Machines Corporation
October 26, 2017 - N°20170310702

A local segment analysis and security (lsas) engine method, computer program product, and apparatus are provided. The lsas engine collects status metrics indicating a current operational status of the computing resources within a first segment of a computing environment, analyzes the status metrics to determine whether the first segment is the target of a first attack, and receives, from another ...
Metal-antibody tagging and plasma-based detection
Purdue Research Foundation
October 26, 2017 - N°20170307533

An apparatus and method for characterizing a target, e. G., microbial samples or biological toxins, includes labeling the target with a biomolecular recognition construct and measuring an atomic-spectra signal of the biomolecular recognition construct. The method can include heating the labeled target before measuring the atomic-spectra signal. The atomic-spectra signal can be measured by performing laser-induced breakdown spectroscopy. The atomic-spectra ...
Vh scaffold
Crescendo Biologics Limited
October 26, 2017 - N°20170306319

The invention provides human vh scaffold sequences, libraries derived therefrom and methods of producing. The scaffolds have high expression, solubility and are functional.
Tissue-engineered constructs
Humacyte, Inc.
October 26, 2017 - N°20170306292

The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.
Human vh domain scaffolds
Crescendo Biologics Limited
October 26, 2017 - N°20170306039

The invention provides human vh scaffold sequences, libraries derived therefrom and methods of producing. The scaffolds have high expression, solubility and are functional.
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