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This page is updated frequently with new Scaffold-related patent applications.




patent app List of recent Scaffold-related patents
 Methods and systems for large scale scaffolding of genome assemblies patent thumbnailMethods and systems for large scale scaffolding of genome assemblies
Computational methods used for large scale scaffolding of a genome assembly are provided. Such methods may include a step of applying a location clustering model to a test set of contigs to form two or more location cluster groups, each location cluster group comprising one or more location-clustered contigs; a step of applying an ordering model to each of the two or more location cluster groups to form an ordered set of one or more location-clustered contigs within each cluster group; and a step of applying an orienting model to each ordered set of one or more location-clustered contigs to assign a relative orientation to each of the location-clustered contigs within each location cluster group.
University Of Washington


 Adjustable scaffolding patent thumbnailAdjustable scaffolding
An adjustable scaffolding that may adjust to the curvature of a structure. The adjustable scaffolding may comprise a main member, pegs, wing platforms, and rails.
Tarsco Construction Corporation


 Method for producing segmental aneuploidy (san) strains of trichoderma reesei via sexual crossing and san strains produced therefrom patent thumbnailMethod for producing segmental aneuploidy (san) strains of trichoderma reesei via sexual crossing and san strains produced therefrom
The present invention relates to a technology to provide segmental aneuploidy progeny strains of trichoderma reesei. In particular, the present invention relates to a method to produce segmental aneuploidy progeny strains of trichoderma reesei via sexual crossing of two parent haploid strains with chromosome heterozygosity (e.g.
Academia Sinica


 Pri-mirna libraries and methods for making and using pri-mirna libraries patent thumbnailPri-mirna libraries and methods for making and using pri-mirna libraries
Provided are methods for the design, preparation, and use of non-native pri-micrornas (pri-mirnas), pri-microrna (pri-mirna) scaffolds, and libraries of non-native pri-mirnas employing pri-mirna scaffolds. Also provided are methods for identifying non-native pri-mirnas, combinations of two or more non-native pri-mirnas, and mirnas derived from the processing of such non-native pri-mirnas, which mirnas exhibit one or more desired functional activities.

 Synthetic single domain antibody patent thumbnailSynthetic single domain antibody
The invention relates to the identification of a highly stable single domain antibody scaffold (hs2d ab) and its use in generating synthetic single domain antibody library (hs2d ab-l1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics..
Centre National De La Recherche Scientifique - Cnrs


 Wound cleansing apparatus patent thumbnailWound cleansing apparatus
An apparatus for cleansing and promoting tissue growth in wounds, in which irrigant fluid optionally containing cell nutrients and/or other physiologically active material from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing, a biodegradable scaffold in contact with the wound bed and a means for fluid cleansing and back to the dressing. The apparatus has means for supplying thermal energy to the fluid in the wound.
Smith & Nephew Plc


 Decellularized hyaline cartilage powder for tissue scaffolds patent thumbnailDecellularized hyaline cartilage powder for tissue scaffolds
The present invention is related to compositions comprising decellularized cartilage tissue powder in the forms of paste, putty, hydrogel, and scaffolds, methods of making compositions, and methods of using these compositions for treating osteochondral defects and full- or partial-thickness cartilage defects.. .
The University Of Kansas


 Flexible stent with torque-absorbing connectors patent thumbnailFlexible stent with torque-absorbing connectors
The present invention concerns an endoprosthesis with a highly flexible structure that is configured to provide an elevated degree of vessel scaffolding and to absorb torque applied on the endoprosthesis. In one embodiment, a method of deploying the endoprosthesis in a body lumen includes locating an endoprosthesis in a contracted delivery configuration in the body lumen, disposing the endoprosthesis in a location of the body lumen to receive the endoprosthesis in an expanded deployed configuration, and deploying the endoprosthesis to transition the endoprosthesis from the contracted delivery configuration to the expanded deployed configuration.
Abbott Laboratories Vascular Enterprises Limited


 Synthetic bone grafts constructed from carbon foam materials patent thumbnailSynthetic bone grafts constructed from carbon foam materials
A porous, self-sustaining body useful as a scaffold for bone grafting is provided. The scaffold comprises a carbonaceous matrix comprising a continuous phase having a surface and defining a plurality of open spaces throughout the matrix.
Cibor, Inc.


 Method and  centering a microcatheter within a vasculature patent thumbnailMethod and centering a microcatheter within a vasculature
The invention is directed to methods and apparatus for centering a microcatheter within a vasculature. In one aspect, the methods and apparatus can be used to support centering and to facilitate a guidewire to cross through a chronic total occlusion.
Roxwood Medical, Inc.


Suspended scaffolding and suspending device therefore


A suspended scaffold comprises a work platform (6) and at least one suspending device (2) via which the work platform (6) is attachable to an object (1). The suspending device (2) comprises a claw device (3) intended and configured to engage optionally directly on the object (1), and a coupling device (4).
Brand Energy Holdings B.v.


Multiple scaffold design and coating thereof


A multiple stent structure including a plurality of stent bodies arranged end to end in which adjacent stent bodies of the structure are connected by a severable connecting portion disposed between the adjacent stent bodies is disclosed. A method of coating a plurality of stents including depositing a coating on the multiple stent structure and severing the severable connecting portions to disconnect the plurality of stent bodies is disclosed..
Abbott Cardiovascular Systems Inc.


Bone tissue engineering by ex vivo stem cells ongrowth into three-dimensional trabecular metal


Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue..

Biomimetic biphasic 3d nanocomposite scaffold for osteochondral regeneration


The invention describes methods for producing a biphasic nanocomposite scaffold comprising custom polymer-based core-shelled nanospheres by the physical and chemical attachment of two disparate polymeric materials whose composition can be readily modified with tissue-specific nanomaterials and products created using such methods. The custom nanospheres are constructed via co-axial wet electrospraying and can be employed to deliver compounds to the polymeric materials..
The George Washington University, A Congressionally Chartered Not-for-profit Corpor


Scaffold


A scaffold for tissue repair or wound dressing comprising: a material layer; a polymer fibre layer; and an adhesive component between the material layer and the polymer fibre layer, wherein the adhesive component comprises material having a lower melting temperature (tm) than the material layer and the polymer fibre layer.. .
Isis Innovation Limited


Continuous cell programming devices


The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer..
Dana-farber Cancer Institute, Inc.


Scaffolds having radiopaque markers


A scaffold includes a radiopaque marker connected to a strut. The marker is retained within the strut by one or more of a mechanical interference fit, a polymer coating or melt, and/or by friction.
Abbott Cardiovascular Systems Inc.


Artificial vascular graft


The invention relates to an artificial vascular graft comprising a primary scaffold structure encompassing an inner space of the artificial vascular graft, said primary scaffold structure having an inner surface facing towards said inner space and an outer surface facing away from said inner space, a coating on said inner surface, wherein a plurality of grooves is comprised in said coating of said inner surface. The primary scaffold structure comprises further a coating on said outer surface.
UniversitÄtsspital Basel


Contact lenses having a reinforcing scaffold


Ophthalmic lenses for correcting refractive error of an eye are disclosed. Ophthalmic lenses include an inner optic portion having a scaffold between an anterior portion and a posterior portion.
Nexisvision, Inc.


Telescopic support rod


Systems and methods for adjustable telescopic support rods are provided. Specifically, the telescopic support rods in accordance with some embodiments comprise selectably modifiable indexed lengths having no externally visible indication of the indexing means.

Standing seam mounting brackets


A standing seam mounting bracket and a method of using two or three to provide attachment points along a standing seam roof is provided. The standing seam mounting brackets enable complementary use of commonly-owned equipment for enabling roof maintenance and construction.

Novel polypeptides


The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are specific for the human and rat protease plasma kallikrein and are modified in one or two peptide loops to enhance potency and/or protease resistance..
Bicycle Therapeutics Limtied


3-dimensional cardiac fibroblast derived extracellular matrix


A bioscaffold made from an isolated cardiac fibroblast-derived 3-dimensional extracellular matrix (ecm) is disclosed. The bioscaffold can be used as an epicardial patch for the delivery of therapeutic cells into myocardial tissue.
Wisconsin Alumni Research Foundation


Protein-polymer-drug conjugates


Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (pbrm) and a polymeric carrier substituted with one or more -ld-d, the protein based recognition-molecule being connected to the polymeric carrier by lp.
Mersana Therapeutics, Inc.


Metalloproteinase-cleavable alpha-amanitin-dendrimer conjugates and treating cancer


A conjugate comprising a dendritic polymer or other scaffold, a metalloproteinase-cleavable linker and alpha-amanitin. Methods of using this conjugate for safe targeted treatment of cancer cells expressing metalloproteinases..
King Abdullah International Medical Research Center


Continuous cell programming devices


The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer..
Dana-farber Cancer Institute, Inc.


Continuous cell programming devices


The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer..
Dana-farber Cancer Institute, Inc.


Wall mounted handrail for scaffolding


A handrail assembly for scaffolding comprising a first hand rail component and a second hand rail component, wherein said first hand rail component is slidingly connected to said second hand rail component; a first frame, wherein said first hand rail component is slidingly connected to said first frame; a first wall hook, wherein said first frame is slidingly connected to said first wall hook; a second frame, wherein said second hand rail component is slidingly connected to said second frame; and a second wall hook, wherein said second frame is slidingly connected to said second wall hook.. .

Robotic electroprosessing system and method


The present invention includes a robotic system for the enhanced automation, manipulation, and control of electroprocessing in two or three dimensions. In one embodiment, the system includes a sealed chamber devoid of any electrical or conductive components which would interfere with the electrical field and eventual material fabrication, while still allowing for two-dimensional and three-dimensional robot motion.
Temple University-of The Commonwealth System Of Higher Education


Carbon nanotube compositions and methods of use thereof


Carbon nanotube (cnt)-based compositions for activating cellular immune responses are provided. The cnts function as high surface area scaffolds for the attachment of t cell ligands and/or antigens.
Yale University


Advanced functional biocompatible polymeric matrix containing nano-compartments


The present invention provides a novel biomaterial which is a hybrid, self-assembling biopolymeric networked film that is functionalized through hydrophobic interactions with vesicles loaded with bioactive agents. The biomaterial compound is a polymeric network of hydrophobically modified chitosan scaffolds that is taken from solution and formed as a solid film.
University Of Maryland, College Park


Magnesium alloy implants with controlled degradation


Stents or scaffolds made from magnesium or magnesium alloys including additives or barrier coatings that modify the corrosion rate of the stent are disclosed. Methods of forming barrier coatings that modify the corrosion rate of the stent are disclosed..
Abbott Cardiovascular Systems Inc.


Rigid intervertebral scaffolding


An intervertebral scaffolding system is provided having a central beam having a proximal portion having an end, a grafting portion having a top and a bottom, a distal portion having a end, a central beam axis, a graft distribution channel having an entry port at the end of the proximal portion, a top exit port at the top of the grafting portion, and a bottom exit port at the bottom of the grafting portion. These systems can also include a laterovertically-expanding frame operable for a reversible collapse from an expanded state into a collapsed state.
Ouroboros Medical, Inc.


Interventional device having an integrated embolic filter and associated methods


A percutaneous transluminal device, comprising an elongated catheter, an interventional device operably coupled to the proximal end of the catheter, a filter operably coupled to the distal end of the catheter, the filter movable between a collapsed and deployed position 218, and an actuator wire for deploying the collapsing the filter. The filter including a filter chassis comprising a movable collar a fixed collar and a tubular braided scaffolding coupled between the movable collar and the fixed collar.
Contego Medical, Llc


Method for animal tissue material disinfection and sterilization and corresponding animal tissue soak solution


A method for disinfecting and sterilizing an animal tissue material and a corresponding soak solution for an animal tissue. The method includes placing the animal tissue material into an alkaline soak solution containing a metal peroxide and a detergent, and shaking; removing organic components released from microorganisms and animal tissue cells by soaking and washing in a neutral cleaning solution; washing the tissue matrix with a weak acidic cleaning solution; cryopreserving or freeze-drying the tissue matrix in a neutral solution.
Beijing Ruijian Gaoke Biotechnology Co., Ltd.


Antigen-binding constructs


The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired vh/vl domain, methods of making such constructs and uses thereof.. .
Glaxo Group Limited


High affinity synbodies for influenza


Composition of synbodies that bind influenza. The synbodies are composed of two peptides joined on a scaffold..
Arizona Board Of Regents On Behalf Of Arizona State University


Multivalent heteromultimer scaffold design and constructs


Provided herein are multifunctional heteromultimer proteins. In specific embodiments is a heteromultimer comprising: at least two polypeptide constructs, each polypeptide construct comprising at least one cargo polypeptide attached to a transporter polypeptide, said transporter polypeptides derived from a monomeric native protein such that said monomeric constructs associate to form the heteromultimer and said transporter polypeptides associate to form a quasi-native structure of the monomeric native protein or analog thereof.
Zymeworks Inc.


Cross-linked platelet material


This document provides methods and materials involved in making and using cross-linked platelet material (e.g., cross-linked lysate material from human platelets such as human platelets obtained from platelet blood collection preparations or platelet apheresis preparations). For example, methods and materials for cross-linking platelet material (e.g., lysate material obtained from human platelets) to form a matrix (e.g.
Mayo Foundation For Medical Education And Research


Matrix scaffold for three-dimensional cell cultivation, methods of construction thereof and uses thereof


This invention provides a matrix scaffold for three-dimensional (3d) cell cultivation, a method of its construction, and its uses. The matrix scaffold results from a crosslinking reaction of a fibroin-like substance prepared by a specific method from silk cocoons or filaments, chitosan and crosslinking agents.
Suzhou Cancercell Biotechnology Co. Ltd


Composite support containing silk and collagen, and preparation method thereof


Embodiments of the present invention relate to a biodegradable scaffold for replacing tissue or inducing tissue regeneration and a preparation method thereof, wherein the scaffold comprises at least one woven silk tube layer and a collagen layer inside the tube layer. The scaffold is excellent in terms of tissue regeneration and mechanical properties and causes little or no immune response after implantation.
Dongguk University Industry-academic Cooperation Foundation


Modularly assembled small molecules for the treatment of myotonic dystrophy type 1


To study rna function using small molecules, we designed bioactive, modularly assembled small molecules that target the noncoding expanded rna repeat that causes myotonic dystrophy type 1 (dm1), r(cug)exp. Different modular assembly scaffolds were investigated including polyamines, alpha-peptides, beta-peptides, and peptide tertiary amides (pt as).
The Scripps Research Institute


Three dimensional soy protein-containing scaffolds and methods for their use and production


Porous soy protein-based scaffolds and methods for making the scaffolds using 3d printing techniques are provided. Also provided are tissue growth scaffolds comprising the porous soy protein-based scaffolds and methods for growing tissue on the tissue growth scaffolds.
Northwestern University


Use of compounds with thrombopoietic activity to promote bone growth and healing


Tpo was used to promote the growth of bone in both rats and in mice. Gaps in both mouse and in rat bones were treated with a scaffold sized to fit the gap.
Indiana University Research & Technology Corporation


Engineered integrin binding peptide compositions


Engineered peptides that bind with high affinity (low equilibrium dissociation constant (kd)) to the cell surface receptors of fibronectin (α5β1) or vitronectin (αvβ3 and αvβ5 integrins) are disclosed as useful as imaging tissue. These peptides are based on a molecular scaffold into which a subsequence containing the rgd integrin-binding motif has been inserted.
The Board Of Trustees Of The Leland Stanford Junior University


Stabilized, laterovertically-expanding fusion cage systems


An intervertebral scaffolding system is provided having a laterovertically-expanding frame operable for a reversible collapse from an expanded state into a collapsed state, the laterovertically-expanding frame having a stabilizer that slidably engages with the distal region of the laterovertically-expanding frame and is configured for retaining the laterovertically-expanding frame from a lateral movement that exceeds the expanded state. The expanded state, for example, can be configured to have an open graft distribution window that at least substantially closes upon the reversible collapse..
Ouroboros Medical, Inc.


Systems and methods for managing a patient


Implementations described and claimed herein provide systems and methods for managing one or more patients. In one implementation, an imaging window is determined based on a location of a probe.
Guardsman Scientific, Inc.


Dual latching horizontal scaffold member


One embodiment of the invention is a horizontal scaffold member having a primary end connector and a secondary end connector. Each end connector is configured to couple to a cup on a vertical scaffold member.
Next Generation Scaffold Services, Inc.


Methods for the site-selective introduction of halogen into natural products


Organohalides (e.g., organofluorides) represent a rapidly expanding proportion of molecules used in pharmaceuticals, diagnostics, agrochemicals, and materials. The present invention exploits the naturally occurring acetate condensation pathway as a means of introducing halogenated building blocks into natural product scaffolds.
The Regents Of The University Of California


Scaffold and implanting cells


The disclosure provides for a bone implant for replacing at least a portion of a bone of a patient. The bone implant includes a support structure being a non-antigenic porous natural collagen matrix configured to receive cells, the support structure formed by removing tissue and cells from a bone obtained from a body leaving only the non-antigenic collagen matrix, the support structure having a configuration corresponding to the configuration of the bone to be replaced, the support structure having a plurality of passages through which blood may flow.
P Tech, Llc


Molecule detection using boronic acid substituted probes


Provided are polymeric scaffold compositions and methods for detecting or quantitating diols such as carbohydrates or carbohydrate containing molecules (e.g., glycosylated protein). Provided herein are capture probes configured to bind to a scaffold.
Two Pore Guys, Inc.


Binding polypeptides having a mutated scaffold


The present disclosure relates to a class of engineered polypeptides and provides a polypeptide comprising the sequence ex2x3x4ax6x7eix10 x11lpnlx16x17x18qx20 x21 afix25x26lx28x29x30 px32qsx35x36llx39e akklx45x46x47q (seq id no: 55). The present disclosure also relates to populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the amino acid sequence ex2x3x4ax6x7eix10 x11 lpnlx16x17x18qx20 x21 afix25x26lx28x29x30 px32qsx35x36llx39e akklx45x46x47q (seq id no: 55), and methods for selecting a desired polypeptide having an affinity for a predetermined target from said population..
Affibody Ab


3-dimensional bioscaffolds


The invention concerns an apparatus and a method for the manufacture of a three-dimensional (3d) bioscaffold; a 3d bioscaffold made using same; and the use of said 3d bioscaffold in the manufacture of an implant to treat injuries such as, but not limited to, meniscal injuries.. .
National University Of Singapore


Scaffold having a shaped strut and methods for shaping scaffold struts


A scaffold strut is shaped to improve hemocompatibility. After laser cutting, the scaffold is placed on a work piece and its struts are shaped by flame polishing or brushing.
Abbott Cardiovascular Systems Inc.


Novel nanocomposites and their application as monolith columns


Novel materials for chromatographic separations, processes for their preparation, and separation devices containing the chromatographic materials. In particular, hybrid inorganic/organic monolith materials comprising a polymerized scaffolding nanocomposite (psn), wherein the nanocomposite contains a scaffolding functionality capable of chemically interacting with a surface of a second material are described.
Waters Technologies Corporation


Method for preparing an animal decellularized tissue matrix material and a decellularized tissue matrix material prepared thereby


A method for manufacturing an animal acellular tissue matrix material and a tissue matrix material manufactured by the same. The tissue matrix material manufactured by the method retains an original basic scaffold structure of a tissue extracellular matrix, with an antigen causing immunological rejection in a human body being effectively removed from the animal tissue.
Beijing Ruijian Gaoke Biotechnology Co., Ltd.


Collagen scaffold modified by covalent grafting of adhesion molecules, associated methods and use thereof for cardiovascular and thoracic cell therapy and contractile tissue engineering


Three-dimensional solid contractile collagen scaffolds having improved biological properties and electromechanical performance are provided. The scaffolds can be used for cell transplantation, including the fixation of biocompatible reagents and adhesion molecules which control cell adhesion, apoptosis, survival and/or differentiation simultaneously.

Photocrosslinkable poly(caprolactone fumarate)


Fumaric acid or a salt thereof, such as a fumaryl halide (e.g. Fumaryl chloride), which contains unsaturated carbon-carbon double bonds that can be used for in situ crosslinking, is copolymerized with poly(caprolactone) diol in the presence of an alkali metal salt.
Mayo Foundation For Medical Education And Research


Scaffolds containing cytokines for tissue engineering


The present disclosure provides biocompatible scaffold that promotes m1 or m2 macrophage phenotypes so as to increase vascularization or healing. Also provided are methods of treating a subject in need with the scaffolds described here..
The Trustees Of Columbia University In The City Of New York


Scaffolded nucleic acid polymer particles and methods of making and using


The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their volumes for higher loading capacities than those achievable solely with surface attachment.
Life Technologies Corporation


Perfusion bioreactor


In some embodiments the present invention provides perfusion bioreactors and cell culture scaffolds suitable for the preparation of tissue grafts, such as bone tissue grafts. In some embodiments, the perfusion bioreactors comprise a graft chamber and/or a graft chamber insert configured to hold a tissue graft having a certain shape and/or certain dimensions, and/or to allow culture of such tissue grafts under press-fit direct perfusion conditions.
New York Stem Cell Foundation, Inc.


Fusion protein of therapeutic polypeptide with improved pharmacokinetic profile and use therof


The present invention provides a fusion protein comprising a therapeutic polypeptide fused to one or more flexible unstructured polypeptides and a trimeric scaffold protein. The flexible unstructured polypeptide sequence within the fusion protein is exhibited as one or more pcloud sequences derived from human fibrinogen alpha chain, and may be flanked by a proteinous connecting moiety of human origin.
Beijing Anxinhuaide Biotech. Co., Ltd.


Transparent hydrogel and making the same from functionalized natural polymers


The present invention relates to a novel hydrogel derived from a methacrylated or acrylated natural polymer and a synthetic polymer, and a method of preparing the same. The invention further relates to 3d scaffolds and implants comprising said hydrogel..
Uab Ferentis


A flap for de-novo tissue regeneration


The present invention provides an implant which includes: (a) an autologous engineered tissue; and (b) a vasculature, wherein the engineered tissue is a porous scaffold embedded with endothelial cell, a fibroblast, a myoblast, a mesenchymal cell, an adipocyte, or any combination thereof, wherein the vasculature feeds the cells. Further, the invention provides a method for treating a subject afflicted with a large soft tissue defect by implanting the implant of the invention..
Health Corporation-rambam


Cell permeable inhibitors of the scaffold protein plenty of sh3 domains (posh) or sh3rfl


Plenty of sii3 (posh) and ink-interacting protein 1 (jip-1) function as a multi-protein scaffold network for tcr-mediated jnk1 activation in cd8+ t-cells. Disruption of the posh/jip-1 complex led to profound defects in the activation of jnk1, as well as deficient activation or induction of the transcription factors c-jun, t-bet and eomesodermin furthermore, disruption of the posh/jip complex in cd8+t-cells resulted in impaired proliferation, decreased cytokine expression and the inability to control tumors.
The Curators Of The University Of Missouri


Systems and methods for magnetized stent having growth-promoting properties


Embodiments relate to systems and methods for magnetized stent having growth-promoting properties. A stent assembly comprising a tubular elongated body having a magnetized region and a tissue nidus area is inserted beneath the orifice of a vascular aneurysm.
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.


Scaffold deck system with bracket-supported partial length planks for creating an opening to accommodate obstacles


A scaffold including a pair of scaffold frames has a scaffold platform supported by the frames, which is defined by a series of planks and includes an opening. The opening is formed by a pair of transverse support members that extend between the pair of planks at a location between the scaffold frames.

Cable-panel connector for bridge platform or other scaffolding


In another connector, the free end portion has a plurality of spaced grooves engageable by mating structure on the second plate for achieving the latched state. The mating structure comprises an elongate member in an inclined slot.

Artificial cellulosomes comprising multiple scaffolds and uses thereof in biomass degradation


Multi-enzyme complexes comprising an array of scaffold subunits designed for efficient integration of a plurality of carbohydrate-active enzymes are provided.. .

Three dimensional purified collagen matrices


Cell culture scaffolds presenting a more biologically relevant microenvironment are disclosed. More particularly, these cell culture scaffolds comprise three-dimensional matrices/biomaterials that are created from solubilized collagen compositions using controlled conditions to have the desired microstructure and mechanical properties.

Functionalization of nanofibrous microfiltration membranes for water purification


A high flux and low pressure drop microfiltration (mf) membrane and a method for making the mf membrane. The microfiltration membranes are formed by a method that includes: preparing a nanofibrous structure; and modifying the surface of the nanofibrous structure with a surface modifier.

Solubilization of antigen components for removal from tissues


The present invention relates to methods for removing antigens from tissues by sequentially destabilizing and/or depolymerizing cytoskeletal components and removing and/or reducing water-soluble antigens and lipid-soluble antigens. The invention further relates to tissue scaffolding and decellularized extracellular matrix produced by such methods..

Segmented scaffolds and delivery thereof for peripheral applications


Segmented scaffolds composed of disconnected scaffold segments are delivered to an implant site on a delivery balloon. The segments are crimped to the balloon and separated from each other by gaps.

High-strength biological scaffold material and preparation method thereof


A high-strength biological scaffold and preparation method thereof. The biological scaffold is comprised of a framework of boiled-off silk woven material, the form of the framework is determined by actual needs; the framework surface is coated with a layer of silk protein scaffold material, fibroin protein/gelatin biological scaffold material or fibroin protein/collagen biological scaffold material having a thickness of 100 micrometers to 5 centimeters.

Matrix for dental tissue regeneration


The present invention relates to a biomimetic matrix for providing structural support and scaffolding that allows for regeneration of dentin, pulp, and periodontal tissues. A method of making the biomimetic matrix provides the ability to select both a size of a pore or tubule formed in the biomimetic matrix and a density of pores or tubules disposed throughout the biomimetic matrix.

Methods, devices and systems for sensing, measuring and/or characterizing vessel and/or lesion compliance and/or elastance changes during vascular procedures


The present system is directed in various embodiments to methods, devices and systems for sensing, measuring and evaluating compliance and/or elastance in a bodily conduit. In other embodiments, the methods, devices and systems sense, measure, determine, display and/or interpret compliance and/or elastance in a bodily conduit and/or a lesion within the bodily conduit using fractional flow reserve and/or flow velocity measurements as well as resistance to flow calculations in certain embodiments.

Methods, devices and systems for sensing, measuring and/or characterizing vessel and/or lesion compliance and/or elastance changes during vascular procedures


The present system is directed in various embodiments to methods, devices and systems for sensing, measuring and evaluating compliance in a bodily conduit. In other embodiments, the methods, devices and systems sense, measure, determine, display and/or interpret compliance in a bodily conduit and/or a lesion within the bodily conduit.

Scaffold


Scaffolding unit to be attached to the deck structure of a bridge or similar comprises a set of arms for carrying working levels and the support structures needed in work and an attachment frame for attaching the set of arms to the upper surface of the deck structure. The set of arms is connected to the attachment frame by means of a pivoted parallelogram..

Modular roof mounted staging bracket with safety rails


An apparatus for supporting workers and materials above-grade on both the eave and gable ends of a structure is disclosed. The apparatus can be combined with one or more additional staging apparatuses to create a staging system for the support of persons or materials while work is being done on a structure, e.g., roofing, siding, etc.

Pivoting horizontal and vertical scaffold members and a erecting an offset scaffold platform


One embodiment of the invention is a horizontal scaffold truss that has upper and lower horizontal scaffold members offset but fixedly joined with braces. Each upper and lower members have a connector positioned on each end of the respective lower and upper members, where at least one of the connectors is pivotally mounted on the respective lower or upper connector, and the connectors are engageable with an annular member positioned on a vertical scaffold member..



Scaffold topics: Nucleotide, Recombinant, Polynucleotide, Amino Acid, Biodegradable, Encapsulation, Surfactant, Enhancement, Monoclonal Antibody, Polypeptide, Immunogenic, Amino Acid Sequence, Monoclonal, Interleukin 2, Immune Disease

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