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This page is updated frequently with new Scaffold-related patent applications. Subscribe to the Scaffold RSS feed to automatically get the update: related Scaffold RSS feeds. RSS updates for this page: Scaffold RSS RSS


Biphasic osteochondral scaffold for reconstruction of articular cartilage

Trustees Of Stevens Institute Of Technology

Biphasic osteochondral scaffold for reconstruction of articular cartilage

Date/App# patent app List of recent Scaffold-related patents
04/23/15
20150112422
 Medical device for implantation into luminal structures incorporating corrugated structural elements patent thumbnailnew patent Medical device for implantation into luminal structures incorporating corrugated structural elements
Expandable scaffolds or stents include circumferential elements having a corrugated pattern, which can include a plurality of linear or nonlinear segments. The corrugated pattern distributes stress more uniformly along the circumferential elements, improves radial strength of the scaffolds, reduces acute recoil after deployment, and reduces creep.
Orbusneich Medical, Inc.
04/23/15
20150112419
 Laminous vascular constructs combining cell sheet engineering and electrospinning technologies patent thumbnailnew patent Laminous vascular constructs combining cell sheet engineering and electrospinning technologies
Vascular scaffolds and methods of fabricating the same are disclosed for tissue engineering of vascular constructs. By combining electrospun matrices with cell sheet technologies, vascular constructs with more mature cell layers can be obtained for reconstruction of blood vessels, heart valves and the like.
Wake Forest University Health Sciences
04/23/15
20150112244
 Selectively polymerizable compositions and methods of use in vivo patent thumbnailnew patent Selectively polymerizable compositions and methods of use in vivo
Otologic materials and methods are provided. For example, a cell-adhesive, biodegradable hydrogel scaffold loaded with time-released drugs for repairing chronic tympanic membrane perforations is disclosed, methods of making same and administering same are provided.
The Administrators Of The Tulane Educational Fund
04/23/15
20150111764
 Polymerized microarrays patent thumbnailnew patent Polymerized microarrays
Micropatterns of glycan-bearing brush polymers generated by the initiation of oligomerization of acrylate and methacrylate monomers from thiol-terminated surfaces. Chain lengths are controlled in situ by varying exposure time, and these multivalent glycan scaffolds detect glycan binding proteins at sub-micromolar concentrations..
New York University
04/23/15
20150110846
 Biphasic osteochondral scaffold for reconstruction of articular cartilage patent thumbnailnew patent Biphasic osteochondral scaffold for reconstruction of articular cartilage
An osteochondral scaffold has a chondrogenic spiral scaffold in one end of an outer shell made of sintered microspheres, and an osteogenic spiral scaffold in the other end of the outer shell. Each spiral scaffold has nanofibers of a composition selected to promote attachment and proliferation of the desired types of cells.
The Trustees Of The Stevens Institute Of Technology
04/23/15
20150110753
 Biomatrix scaffolds patent thumbnailnew patent Biomatrix scaffolds
The present invention provides biomatrix scaffolds, a tissue extract enriched for extracellular matrix components and bound growth factors, cytokines and hormones, and methods of making and using same.. .
The University Of North Carolina At Chapel Hill
04/23/15
20150110748
 Bone grafts including osteogenic stem cells, and methods relating to the same patent thumbnailnew patent Bone grafts including osteogenic stem cells, and methods relating to the same
Bone grafts and constructs including stem cells are provided. Example bone grafts include osteogenic stem cells seeded on a scaffold of osteoconductive cortico-cancellous chips and/or osteoinductive demineralized bone.
Globus Medical, Inc.
04/23/15
20150110747
 Bone grafts including osteogenic stem cells, and methods relating to the same patent thumbnailnew patent Bone grafts including osteogenic stem cells, and methods relating to the same
Bone grafts and constructs including stem cells are provided. Example bone grafts include osteogenic stem cells seeded on a scaffold of osteoconductive cortico-cancellous chips and/or osteoinductive demineralized bone.
04/23/15
20150108199
 Tissue thickness compensator comprising tissue ingrowth features patent thumbnailnew patent Tissue thickness compensator comprising tissue ingrowth features
In various embodiments, a compensator can be attachable to an anvil of a fastening instrument. The compensator can comprise a support layer configured to be attached to the anvil and a scaffold attached to the support layer.
Ethicon Endo-surgery, Inc.
04/16/15
20150105863
 Fiber-reinforced hydrogel composites and methods of forming fiber-reinforced hydrogel composites patent thumbnailFiber-reinforced hydrogel composites and methods of forming fiber-reinforced hydrogel composites
A fiber-reinforced hydrogel composite is provided. The composite includes a hydrogel and a fibrous component containing a plurality of fibers.
National University Of Singapore
04/16/15
20150105848

Graft systems having filling structures supported by scaffolds and methods for their use


Aneurysms are treated by filling at least one double-walled filling structure with a curable medium within the aneurysm. The filling structures may be delivered over balloon deployment mechanisms in order to shape and open tubular lumens therethrough.
Nellix, Inc.
04/16/15
20150105319

Durable haemostatic scaffold


A method for preparing a haemostatic and adhesive durable scaffold useful for promoting wound healing, and the scaffold so prepared, are provided. The scaffold made of fibrinogen and chitosan is produced by electrospinning techniques, resulting in a material with enhanced endurance, applicable in various medical purposes including surgery, tissue regeneration, burns, injuries, and the like.
04/16/15
20150104634

Synthesis of three-dimensional graphene foam: use as supercapacitors


The application disloses methods of fabricating three-dimensional (3d) graphene crystalline foam, based on mixing a carbon source with a skelet (scaffold) powder. In one embodiment heat and pressure are used to compact the carbon and a metal powder into a close packed structure.
National University Of Singapore
04/16/15
20150104469

Carriers for improved drug delivery


The invention provides carriers that enhance the absorption, half-life or bioavailability of therapeutic compounds. The carriers comprise targeting groups that bind the vitamin d binding protein (dbp), conjugation groups for coupling the targeting groups to the therapeutic compounds, and optionally scaffolding moieties..
Extend Biosciences, Inc.
04/16/15
20150104407

Protein-polymer-drug conjugates


A polymeric scaffold useful for conjugating with a protein based recognition-molecule (pbrm) to form a pbrm-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups.
Mersana Therapeutics, Inc.
04/16/15
20150101748

Flexible stent with hinged connectors


A composite implantable prosthesis including a scaffold with a plurality of axially spaced apart sections connected by one or more bridges, each bridge including one or more hinges, and methods of making the prosthesis. The material of the bridges may be generally distinct from the material of the scaffold..
C.r. Bard, Inc.
04/09/15
20150100121

Biomimmetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement


An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites.
The Trustees Of Columbia University In The City Of New York
04/09/15
20150099853

Novel biodegradable elastomeric scaffold for tissue engineering and light scattering fingerprinting methods for testing the same


The present invention is directed to a novel biocompatible polymer that may be used in tissue engineering. More specifically, the specification describes methods and compositions for making and using citric acid copolymers..
Northwestern University
04/09/15
20150098955

Cd40l-specific tn3-derived scaffolds and methods of use thereof


The present invention provides tenascin-3 fniii domain-based scaffolds that specifically bind to cd40l. The invention further provides engineered variants with increased affinity for the target.
Medlmmune, Llc
04/02/15
20150094808

Synthetic scaffolds and organ and tissue transplantation


A synthetic scaffold for replacing at least a portion of an airway includes an airway mold, one or more structural ribs on the airway mold, and a non-structural wall. Each of the one or more structural ribs is formed from a first material and the non-structural wall is formed from a second material.
Harvard Apparatus Regenerative Technology, Inc
04/02/15
20150093812

Bioartificial filtration organ


A bioartificial filtration organ can be produced from an organ scaffold by re-seeding the scaffold with endothelial cells or cell progenitors and with epithelial cells or cell progenitors in a negative pressure environment. The negative pressure encourages the re-seeding over a greater extent of the scaffold..
The General Hospital Corporation
04/02/15
20150093449

Method of using silicon substituted phosphates to improve healing of bone and soft tissue


A method of use of silicon substituted phosphates that improves bone and soft tissue growth resulting in better adhesion and fixation of implanted prosthetics, which may be used as part of a tissue engineering scaffold for ligament replacement and results in improved healing of healing of damaged bone and soft tissue ulcers. The silicon substituted phosphates of various chemical composition and granular sizes may be used in direct application or in combination with other materials, not previously claimed in prior art used to treat the various medical conditions described..
04/02/15
20150093428

3d in vitro bi-phasic cartilage-bone construct


A 3d in vitro bi-phasic cartilage-bone organoid includes a layer of an artificial cartilage tissue, and a layer of an artificial bone tissue comprising a structure-giving scaffold and a bone marrow structure. The layer of the artificial cartilage tissue contacts at least one surface of the layer of the artificial bone tissue..
Tissuse Gmbh
03/26/15
20150088241

Sheaths used with polymer scaffolds


A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. A sheath pair is placed over the crimped scaffold after crimping to reduce recoil of the crimped polymer scaffold and maintain scaffold-balloon engagement relied on to hold the scaffold to the balloon when the scaffold is being delivered to a target in a body.
Abbott Cardiovascular Systems Inc.
03/26/15
20150088240

Clip sheath for a polymer scaffold


A sheath is placed over a crimped scaffold to reduce recoil of the crimped polymer scaffold and maintain scaffold-balloon engagement relied on to hold the scaffold to the balloon when the scaffold is being delivered to a target in a body. The sheath has an opening spanning the length of the sheath.
Abbott Cardiovascular Systems Inc.
03/26/15
20150087062

System and electrospun biodegradable scaffold for bone repair


This invention relates a structure and system for growth factor incorporation which can improve the osteogenic differentiation of hmscs, for potential bone regeneration and bone growth applications or used alone for bone repair or growth applications. The system comprises a biodegradable polyester, a hydrophilic polymer, a growth factor and optionally a bioceramic..
03/26/15
20150086993

Microfluidic three-dimensional osteocyte network reconstructed with microbeads as scaffold


A bed of microbeads is used as a foundation for reconstructing a three-dimensional osteocyte network by culturing osteocytes within the bed. The osteocytes are cultured such that they form a network among the microbeads that is capable of simulating the osteocyte network of natural bone.
The Trustees Of The Stevens Institute Of Technology
03/26/15
20150086607

Fiber scaffolds for use creating implantable structures


A synthetic construct suitable for implantation into a biological organism that includes at least one polymer scaffold; wherein the at least one polymer scaffold includes at least one layer of polymer fibers that have been deposited by electrospinning; wherein the orientation of the fibers in the at least one polymer scaffold relative to one another is generally parallel, random, or both; and wherein the at least one polymer scaffold has been adapted to function as at least one of a substantially two-dimensional implantable structure and a substantially three-dimensional implantable tubular structure.. .
03/26/15
20150086602

Methods for coating bone allografts with periosteum-mimetic tissue engineering scaffolds


Methods of coating bone surfaces and coated bones comprising a coating comprising (a) a porous polysaccharide scaffold and/or a plurality of polysaccharide nanofibers; and (b) a polyelectrolyte multilayer composition, are disclosed. The methods of coating bone surfaces and the coated bones disclosed provide a biomimetic periosteum to compensate for periosteum lost in preparing bone grafts, and the coated bone grafts, including allografts, restore lost osteogenic and osteoinductive qualities and improve clinical outcomes..
Colorado State University Research Foundation
03/26/15
20150084438

Techniques for optimizing wireless power transmission


New wireless power transmission techniques are disclosed. In some aspects of the invention, an ambient wave or field is used as a scaffold for building new, superposed waveforms, using an additional, intermediate transmitter or resonator.
03/26/15
20150084232

Poly(ethylene glycol) cross-linking of soft materials to tailor viscoelastic properties for bioprinting


Extrudable hydrogel compositions for printing 3d objects, such as cell growth scaffolds, are provided. Also provided are methods for making the crosslinked hydrogel compositions and the printed objects and methods for culturing cells using the cell growth scaffolds.
Northwestern University
03/19/15
20150081035

Devices and methods for stenting an airway


An implantable device and method are disclosed for stenting an occlusion of an airway. The implantable device includes a cylindrical tube shaped proximal region, a flared distal region, and a non-bifurcated single lumen extending through the device.
Merit Medical Systems, Inc.
03/19/15
20150081033

Scaffold-free self-organizing 3d synthetic tissue and artificial bone complex for bone/cartilage regeneration


An improved method of treating an osteochondral defect is provided, which is a composite tissue for treating or preventing a disease, disorder, or condition associated with an osteochondral defect, comprising a three-dimensional synthetic tissue and an artificial bone, wherein the three-dimensional synthetic tissue is substantially made of a cell and an extracellular matrix derived from the cell, the extracellular matrix contains fibronectin, collagen i, collagen iii, and vitronectin, and the extracellular matrix is diffusedly distributed in the tissue.. .
03/19/15
20150081012

Mesh enclosed tissue constructs


A scaffold to form tissue membranes, comprising: at least one layer of mesh having a first side and a second side, the layer of mesh being either a woven wire metal mesh or a flat metal sheet that is acid-etched such that the layer of mesh includes a network of holes passing directly through the mesh from the first side to the second side; and at least one layer of cells at each side of the mesh enclosing the layer of mesh, such that the at least one layer of cells on the first side interacts with the at least one layer of cells on the second side through the network of holes to provide for structure integration.. .
The Regents Of The University Of California
03/19/15
20150081000

Braided scaffolds


A braided polymeric scaffold, made at least in part from a bioresorbable material is deployed on a catheter that uses a push-pull mechanism to deploy the scaffold. A drug coating is disposed on the scaffold.
Abbott Cardiovascular Systems Inc.
03/19/15
20150080788

Wound treatment apparatus and method


An apparatus and method for aspirating, irrigating and/or cleansing wounds is provided. The apparatus and method include one or more of the following: simultaneous aspiration and irrigation of the wound, supplying of thermal energy to fluid circulated through the wound; supplying physiologically active agents to the wound; a biodegradable scaffold in contact with the wound bed; and application of stress or flow stress to the wound bed..
Smith & Nephew Plc
03/19/15
20150080616

Polymeric nanofibrous composite membranes for energy efficient ethanol dehydration


Membranes are provided for energy efficient purification of alcohol by pervaporation. Such membranes include a nanofibrous scaffold in combination with a barrier layer.
The Research Foundation For The State University Of New York
03/19/15
20150079143

Three-dimensional scaffolds for tissue engineering made by processing complex extracts of natural extracellular matrices


Methods of making a biologically active three-dimensional scaffold capable of supporting growth and differentiation of a cell are described. Biologically active three-dimensional scaffold made by the methods of the invention and an engineered tissue made from the scaffolds are described.
Drexel University
03/19/15
20150077832

Electrochromic window insert assembly and methods of manufacture


An electrochromic insert adapted to be fitted into an existing window frame allowing an existing window to be retrofit to have the benefits of electrochromics. The insert may have a scaffold that fits into a window frame.
Itn Energy System, Inc.
03/19/15
20150075911

Supporting element for scaffolds


A supporting element for scaffolds includes a lower supporting plane or plate suited to be rested on the ground; ribs distributed on top of the lower plane or plate, integral with the lower plane or plate and all having their upper edge lying on the same plane, suited to constitute bearing elements for the bearing base of the scaffold and stiffening elements for the supporting element; a quadrilateral projection or wall, placed on top and generically at the center of the lower plane or plate, whose sides are higher than the ribs, suited to delimit the position where the bearing base of the scaffold rests on the ribs and to prevent the bearing base from slipping on the upper edges of the ribs; and a perimeter wall above the lower plane or plate, parallel to the upper ribs and delimiting the upper ribs.. .
03/19/15
20150075910

Magnetic scaffold tie


A magnetic scaffold tie for coupling a scaffold to a tank, wall or beam. The mount has a base platform having an upper planar face and a lower open face and at least one sidewall, at least one magnet coupled between the upper planar portion and lower open face, and proximate an end of the sidewall, a release bar coupled to a release mechanism, the release bar having a plurality of positions.
03/19/15
20150075667

Carbon macrotubes and methods for making the same


A method of manufacturing a carbon macrotube includes providing at least one layer of graphene and wrapping the at least one layer of graphene around a scaffold material to form a carbon macrotube is disclosed. In other words the carbon macrotube includes at least one layer of graphene having opposed lateral edges that are spirally wrapped around itself so as to form the macrotube..
Lockheed Martin Corporation
03/12/15
20150073564

Tubular porous foam scaffolds with gradient pores for tissue engineering


Novel bioabsorbable polymeric porous tubes for tissue engineering nerve growth are disclosed. The tubes are made from a bioabsorbable polymeric foam material and have a gradient of pore sizes across the wall thickness of the tubes such that cell growth occurs into the wall of the tubes from the inner surface, while cell growth or entry is not permitted through the outer wall into the tubular wall.
Ethicon, Inc.
03/12/15
20150073551

Biomimetic tissue graft for ligament replacement


Implantable biomimetic ligaments suitable for use in ligament replacement, including, but not limited to, that of the anterior cruciate ligament (acl) are provided. The replacement implants consist of a biocompatible degradable polymeric scaffold seeded with mesenchymal stem cells (or a combination of different phenotypes).
The Uab Research Foundation
03/12/15
20150073536

Assessment of a drug eluting bioresorbable vascular scafford


A method of treating vascular disease in a patient is disclosed that comprises deploying a bioabsorbable polymer scaffold composed of a plurality of struts at a stenotic segment of an artery of a patient, wherein after the scaffold supports the segment at an increased diameter for a period of time the polymer degrades and is progressively replaced by de novo formation of malleable provisional matrix comprising proteoglycan, wherein as the scaffold becomes more malleable and becomes disconnected as it degrades, wherein following coverage of the struts by a neointima layer and loss of mechanical support provided by the scaffold, the scaffold is pulled outward by positive remodeling of the vessel wall of the scaffolded segment.. .
Abbott Cardiovascular Systems Inc.
03/12/15
20150073535

Treatment of coronary artery lesions with a scaffold having vessel scaffold interactions that reduce or prevent angina


Methods of treating coronary artery disease (cad) with bioresorbable stents resulting in reduced angina or non-ischemic chest pain are described. Methods of treatment and devices for treatment of angina and post-procedural chest pain that include anti-angina agents incorporated into the device are disclosed..
Abbott Cardiovascular Systems Inc.
03/12/15
20150072919

Fibronectin based scaffold domain proteins that bind to myostatin


The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, copd, chronic kidney disease, heart failure, myocardial infarction, and fibrosis.
Bristol-myers Squibb Company
03/12/15
20150072429

Method for manufacturing a three-dimensional biomimetic scaffold and uses thereof


The present invention relates to a method for manufacturing a three-dimensional (3d) biomimetic scaffold that exploits the use of electrical fields and electrical insulating materials to pattern previously polymerized hydro gels with different molecules and/or macromolecular entities. The invention also relates to the 3d-biomimetic scaffolds obtained and to the uses and applications thereof..
Queen Mary University Of London
03/12/15
20150072357

Cholesteryl succinyl silane bound proteins and methods for producing and using the same


The present invention provides a various three-dimensional polymeric scaffold and methods for producing and using the same. In one embodiment, the three-dimensional polymeric scaffold is used to promote cell migration.
The Arizona Board Of Regents On Behalf Of The University Of Arizona
03/12/15
20150071954

Stable peptide mimetics of the hiv-1 gp41 pre-hairpin intermediate


The present invention relates to a gp41 trivalent peptide mimetic having three gp41 n-peptides on a chemical scaffold which conformationally constrains the n-peptides into a trimeric coiled-coil to mimic gp41 presentation. The present invention also relates to n-peptides having the entire hiv gp41 nh2-terminal heptad repeat region and which are capable of forming gp41 peptide mimetics.
03/12/15
20150068841

Vertical support member for a suspended scaffold assembly, kit for mounting a suspended scaffold assembly, suspended scaffold assembly and mounting the same


A suspended scaffold assembly for mounting a scaffold. The suspended scaffold assembly comprises a plurality of horizontally-spaced-apart vertical support members comprising a suspension cable with at least one coupling ring secured thereto and at least one horizontal member.
9020-4983 Quebec, Inc.
03/12/15
20150068402

Three-dimensional air-adsorbing structure


A three-dimensional air-adsorbing structure. The structure has a three-dimensional, unitary, skeletal, porous scaffold, air-adsorbing material particles, and one or more hydrophobic binders that couple air-adsorbing material particles to each other to form agglomerates and couples particles and agglomerates to the scaffold.
Bose Corporation
03/12/15
20150068011

Scaffold and methods for installing or removing such a scaffold


A scaffold and method(s) for installing or removing such a scaffold that is constructed of at least two vertical frames and of at least two connecting elements that extend essentially horizontally, in each instance, includes at least one connecting element serving as a hip and/or back railing element, vertical supports having respective effective lengths essentially corresponding for example to the vertical distance of the attachment position for the hip and/or back railing element, and horizontal arms set onto one another to form transverse rungs, in each instance, of a ladder for allowing a person to climb up.. .
Wilhelm Layher Verwaltungs-gmbh
03/05/15
20150065420

Vitamin d-ghrelin conjugates


The invention provides carriers that enhance the absorption, half-life or bioavailability of ghrelin peptides. The carriers comprise targeting groups that bind the vitamin d binding protein (dbp), conjugation groups for coupling the targeting groups to the therapeutic compounds, and optionally scaffolding moieties..
Extend Biosciences, Inc.
03/05/15
20150064142

Elastic scaffolds for tissue growth


According to some aspects, tissue scaffolds are provided that comprise one or more types of nanofibers. In some embodiments, one or more design features are incorporated into a tissue scaffold (e.g., an electrospun tissue scaffold) to control the elasticity of the scaffold in at least one direction, making the scaffold suitable for withstanding mechanical forces when implanted in the body of a subject.
Harvard Apparatus Regenerative Technology
03/05/15
20150064130

Protein-polymer-drug conjugates


Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (pbrm) and a polymeric carrier substituted with one or more -ld-d, the protein based recognition-molecule being connected to the polymeric carrier by lp.
Mersana Therapeutics, Inc.
03/05/15
20150060203

Scaffold with an automatic installation characteristic


An automatic scaffold provides one to reach high building in rocesses such as construction, repair, dyeing, coating and maintenance the scaffold includes a scaffold module having multiple superimpose layers, moving columns providing it to be opened by means of a drive unit so as to generate a working distance between the said module layers, vertical and horizontal profiles located between each module layers within the working distance, and guide elements located on the carrier plates and providing the vertical carrier profiles to be fixed.. .
03/05/15
20150059960

Methods for increasing a retention force between a polymeric scaffold and a delivery balloon


A medical device-includes a scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes inflating the delivery balloon during a diameter reduction to improve scaffold retention and maintaining an inflated balloon during the diameter reduction and prior and subsequent dwell periods..
Abbott Cardiovascular Systems Inc.
02/26/15
20150057745

Methods of treatment with drug delivery after biodegradation of the stent scaffolding


Disclosed is a stent comprising a bioabsorbable polymeric scaffolding; and a plurality of depots in at least a portion of the scaffolding, wherein the plurality of depots comprise a bioabsorbable material, wherein the degradation rate of all or substantially all of the bioabsorbable polymer of the scaffolding is faster than the degradation rate of all or substantially all of the bioabsorbable material of the depots.. .
Abbott Cardiovascular Systems Inc.
02/26/15
20150057381

Porogen compositions, methods of making and uses


Provided are porogen compositions and methods of using such porogen compositions in the manufacture of porous materials, for example, porous silicone elastomers. The porogens generally include comprising a core material and shell material different from the core material.
Allergan, Inc.
02/26/15
20150057219

Reversible pegylated drugs


Reversible pegylated drugs are provided by derivatization of free functional groups of the drug selected from amino, hydroxyl, mercapto, phosphate and/or carboxyl with groups sensitive to mild basic conditions such as 9-fluorenylmethoxycarbonyl (fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (fms), to which group a peg moiety is attached. In these pegylated drugs, the peg moiety and the drug residue are not linked directly to each other, but rather both residues are linked to different positions of the scaffold fmoc or fms structure that is highly sensitive to bases and is removable under physiological conditions.
Yeda Research And Development Co., Ltd.
02/26/15
20150057186

Phage display using cotranslational translocation of fusion polypeptides


The present invention relates to a filamentous phage display method wherein the polypeptides of interest displayed on the phage particle are cotranslationally translocated across the cytoplasmic membrane of gram-negative bacteria based on the signal recognition particle pathway. This method is particularly suitable for polypeptides, which are known to be difficult to display on phages, and for proteins of cdna libraries and other combinatorial libraries, in particular when derived from very fast folding, stable protein scaffolds.
University Of Zurich


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Scaffold topics: Nucleotide, Recombinant, Polynucleotide, Amino Acid, Biodegradable, Encapsulation, Surfactant, Enhancement, Monoclonal Antibody, Polypeptide, Immunogenic, Amino Acid Sequence, Monoclonal, Interleukin 2, Immune Disease

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