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Scaffold-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Bioreactor system for stem cell expansion
Synthecon, Inc.
July 20, 2017 - N°20170204358

A bioreactor system for stem cell expansion has a fluid-filled reactor chamber in which stem cells are cultured. The culture compartment of the reactor chamber is transversed by a perfusion core with multiple niche-like scaffolds positioned along the length of the perfusion core. The bioreactor system also uses a media gas exchange module that is free standing and does not ...
NEW Polypeptides targeting vascular endothelial growth factor receptor and prostate specific membrane antigen
The Board Of Trustees Of The Leland Stanford Junior University
July 20, 2017 - N°20170204150

Polypeptides comprising a vegf scaffold modified to bind to psma are provided, and bifunctional derivatives thereof that also bind to vegfr. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment.
NEW Alpha-helix analog having triazine-piperazine backbone and method for preparing same
Postech Academy-industry Foundation
July 20, 2017 - N°20170204086

The alpha-helix mimetic containing a triazine-piperazine scaffold is provided. The alpha-helix mimetic compound can mimic efficiently the alpha-helix structure of protein secondary structure and act as an inhibitor for the protein interaction being specific to various diseases mediated by alpha-helix. Therefore, the compound can be used as a biological probe and have a high potential of drug treating diseases.
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NEW Biomimetic scaffold for regenerative dentistry
Temple University-of The Commonwealth System Of Higher Education
July 20, 2017 - N°20170203009

The present invention relates to biomimetic scaffolds, methods for making the same, and methods for using the same. The scaffolds comprise a plurality of graded or tapered microchannels that provide spatial control for cell penetration. The scaffolds are useful for regenerating missing interface tissue between two adjacent tissues, or regeneration and integration of two adjacent tissues directly.
NEW Bone repair material
Straumann Holding Ag
July 20, 2017 - N°20170203008

Sliceable bone repair material is a porous block-shaped scaffold containing a hydrogel, wherein the hydrogel is formed by michael type addition of at least two precursor molecules. Said scaffold is made of a synthetic ceramic material and has interconnected macropores having a diameter above 100 μm. In addition said scaffold has a total porosity of 60 to 80%. The total volume ...
NEW Amniotic membrane powder and its use in wound healing and tissue engineering constructs
Wake Forest University Health Sciences
July 20, 2017 - N°20170203004

The present invention includes compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane powder. The compositions of the present invention comprise amniotic membrane powder and a scaffold. The methods of the present invention comprises applying a composition of the present invention to a subject to induce wound healing and tissue regeneration.
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  • 470+ full patent PDF documents of Scaffold-related inventions.
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NEW Polymers for thermally-regulated release of hno and other molecules
Pacific Lutheran University
July 20, 2017 - N°20170202874

Multivalent scaffolds configured to facilitate drug release upon exposure to a stimulus, such as heat, or light, are described herein. The multivalent scaffolds are covalently bound to a moiety that is susceptible to decomposition upon exposure to stimulus. The moiety releases hno upon decomposition. In some embodiments, the moiety is in turn linked to an agent to be delivered, such ...
NEW Amphiphilic peptide nanoparticles for use as hydrophobic drug carriers and antibacterial agents
Northeastern University
July 20, 2017 - N°20170202783

Nanoparticulate carrier formulations are useful to solubilize, deliver, and target hydrophobic drugs for treating diseases including cancer and bacterial infections. The formulations contain amphiphilic peptides having a hydrophobic portion and a positively charged hydrophilic portion. The peptides self-associate at nonacidic ph to form mi-celles with a spherical nanoparticle morphology. The hydrophobic core of the nano-particles encapsulates hydrophobic drugs, including antitumor ...
NEW Artificial meniscus
Northeastern University
July 20, 2017 - N°20170202672

An artificial meniscus using a thermoplastic for the base material, which is reinforced with an inert material. In a preferred embodiment, the reinforcement is provided by kevlar® fibers, and the matrix is made out of polycarbonate-urethane (pcu). In an alternate embodiment, the pcu can also be surrounded by a polycaprolactone (pcl) scaffold that is infused with human growth proteins ...
Improved molecular detection system
The University Of Birmingham
July 13, 2017 - N°20170198338

A molecular sensor that utilises dichroism can be used to identify the presence of a target nucleic acid molecule in a sample, for example during or after amplification reactions such as pcr/thermocyling reactions and isothermal reactions. A sensor element for use in the molecular sensor may comprise an alignable scaffold/receptor complex, the receptor of said complex comprising a ...
Polypeptides and their use for treating influenza
University Washington Through Its Center For Commercialization
July 13, 2017 - N°20170198014

Provided herein are scaffold polypeptides, fusion proteins of the scaffold polypeptides and hemagglutinin (ha) binding proteins, and methods for using the fusion proteins for treating and diagnosing influenza infections.
Bone implant materials comprising cross-linked bioactive hydrogel matrices
Pioneer Surgical Technology, Inc.
July 13, 2017 - N°20170197013

The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans ...
New single-step manufacturing process for foamed biomaterials
Universitat Politecnica De Catalunya
July 13, 2017 - N°20170197008

Processes for the preparation of biomaterials, in particular foams and solid structures, suitable for bone surgery and odontology, bone regeneration, bone defect fillings, stabilizing bone fractures, coating of prostheses or implants, fixing of prostheses or implants, drug delivery systems, and tissue engineering scaffolds, and to the biomaterials obtained thereby. Besides that, this invention, also relates to self-setting calcium phosphate foams ...
Scaffold Patent Pack
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Method of bladder augmentation with modified ileal segment and biologically compatible tissue
King Abdulaziz University
July 13, 2017 - N°20170196674

A method of augmenting a bladder including incising a native bladder to form an incised native bladder, implanting a tissue flap, comprising a bladder-expansion portion connected to a tubular portion; and suturing the bladder-expansion portion to an edge of the incised native bladder. The method forms an augmented bladder with a volume capacity that is 100%-250% larger than a volume ...
Material and freeze casting and impregnation method of carbohydrate scaffolds
The Trustees Of Dartmouth College
July 13, 2017 - N°20170196237

An edible includes a directionally porous mass of at least one carbohydrate with a low-moisture infiltrate disposed within pores comprising at least one fat selected from melted chocolate, butter, cocoa butter, coconut oil, palm oil, or cream. The edible is prepared by directionally freeze-casting an aqueous solution or slurry including a carbohydrate; freezing the solution or slurry with directional crystal ...
Cerebrospinal diffusion phantom
The Trustees Of Dartmouth College
July 06, 2017 - N°20170192076

Disclosed herein are cerebrospinal diffusion phantoms which include a housing having a shape and size configured for insertion into a magnetic resonance coil in one or more preselected poses. A scaffold support structure is mounted on an interior of said housing and a plurality of elongated diffusion mimicking members supported on the support array. The elongated diffusion mimicking members are ...
Improved molecular detection system
The University Of Birmingham
July 06, 2017 - N°20170191927

A molecular sensor that utilises dichroism can be used to identify the presence of specific molecules in a substance. The molecular sensor includes a sensor element comprising (i) a scaffold moiety and (ii) one or more receptor molecules for the target molecule attached to the scaffold moiety to form a scaffold/receptor complex, wherein the scaffold/receptor complex is modified ...
Peptides mimicking hiv-1 viral epitopes in the v2 loop for the gp120 surface envelope glycoprotein
New York University
July 06, 2017 - N°20170190764

The present invention relates to an isolated immunogenic peptide comprising a v2 loop fragment from hiv surface envelope glycoprotein gp120. This peptide binds specifically with antibodies in blood of patients vaccinated with a vaccine that has shown protection from hiv-1 infection, does not react with blood of matched patients who did not receive the vaccine, and can, therefore, elicit anti-hiv-1 ...
Cholane derivatives for use in the treatment and/or prevention of fxr and tgr5/gpbar1 ...
Bar Pharmaceuticals S.r.l.
July 06, 2017 - N°20170190731

The present invention relates to compounds having cholane scaffolds of formula (i), said compounds for use in the treatment and/or prevention of fxr and tgr5/gpbar1 mediated diseases.
Manufacturing apparatus for use in low-temperature high-speed manufacturing of support structure and manufacturing method for ...
National Central University
July 06, 2017 - N°20170190107

A manufacturing apparatus for use in the low-temperature high-speed manufacturing of a support structure is introduced. The support structure thus manufactured is for supporting a low-temperature manufacturing scaffold for use in tissue engineering. The manufacturing apparatus includes a frame; a ring-shaped thermally conductive member disposed on the frame; a thermally conductive platform disposed centrally at the ring-shaped thermally conductive member ...
Platform structure for use in low-temperature manufacturing of scaffold for use in tissue engineering and ...
National Central University
July 06, 2017 - N°20170190106

A platform structure for manufacturing a scaffold for use in tissue engineering, comprising a frame; a ring-shaped thermally conductive member fixedly disposed in the frame; a thermally conductive platform centrally movably disposed in the ring-shaped thermally conductive member and having edges in direct contact with inner walls of the ring-shaped thermally conductive member, wherein the thermally conductive platform and the ...
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