|| List of recent Scaffold-related patents
|Activated collagen scaffold materials and their special fused active restoration factors|
Provided are activated collagen scaffold materials as well as their special fused active restoration factors useful for promoting tissue repair, such as bone damage repair or nerve injury repair. The special fused active restoration factors are fusion proteins comprising a collagen-binding domain (cbd) at n-/c-terminus of cytokines, wherein the collagen-binding domain is a polypeptide consisting of 7-27 amino acid residues with a conservative sequence shown in seq id no:12 at n-terminus.
|Glucomannan scaffolding for three-dimensional tissue culture and engineering|
The present invention provides a neutralized glucomannan scaffold capable of promoting cell growth and suitable for three-dimensional tissue culture and engineering. The present invention also provides methods for making and degrading the neutralized glucomannan scaffold.
|Polymer microfilters, devices comprising the same, methods of manufacturing the same, and uses thereof|
A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by uv lithography.
|Activated collagen scaffold materials and their special fused active restoration factors|
Provided are activated collagen scaffold materials as well as their special fused active restoration factors useful for promoting tissue repair, such as bone damage repair or nerve injury repair. The special fused active restoration factors are fusion proteins comprising a collagen-binding domain (cbd) at n-/c-terminus of cytokines, wherein the collagen-binding domain is a polypeptide consisting of 7-27 amino acid residues with a conservative sequence shown in seq id no:4 at n-terminus.
|Coated fiber scaffold for three dimensional cell culture of neural cells|
The invention relates to a biocompatible scaffold for three dimensional cultivation of cells, said scaffold comprise one or more fibers randomly oriented to form a scaffold with open spaces for cultured cells. The one or more fibers are also coated with a bio-active coating and have a diameter of 100-3000 nm..
|Use and fabrication of microscaffolds and nanoscaffolds|
A scaffold includes struts that intersect at nodes. In some instances, a cross section of the cores has at least one dimension less than 100 microns.
|Method of fabricating a three-dimensional (3d) porous electrode architecture for a microbattery|
A method of fabricating a 3d porous electrode architecture comprises forming a microbattery template that includes (a) a lattice structure comprising a first lattice portion separated from a second lattice portion on a substrate, and (b) a solid structure on the substrate including a separating portion between the first and second lattice portions. Interstices of the first lattice portion are infiltrated with a first conductive material and interstices of the second lattice portion are infiltrated with a second conductive material.
|Porous scaffold for tissue engineering and preparation method thereof|
A porous artificial transplant material to replace autogenous bone with excellent biocompatibility, cytocompatibility and biodegradability is provided. More specifically, a porous scaffold for tissue engineering including chitosan/hydroxyapatite-amylopectin (chitosan/hap-ap) and a preparation method thereof are provided.
|Injectable silk fibroin foams and uses thereof|
The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein can be injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection).
|Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment of anti-adm non-ig scaffold for regulating the fluid balance in a patient having a chronic or acute disease|
Patients having a chronic or acute disease or acute condition, especially patients at the icu (intensive care unit) suffer from fluid imbalance. The present invention provides a medicament for regulating the fluid balance and/or improving the fluid balance of such patients.
|Three-dimensional air-adsorbing structure|
A three-dimensional air-adsorbing structure for use in a volume in which there is a time-varying acoustic field. The structure has a three-dimensional, unitary, skeletal, porous scaffold having scaffold openings distributed within its volume, where the scaffold openings make up at least about 50% of the volume of the scaffold, air-adsorbing material particles, and a hydrophobic binder that couples air-adsorbing material particles to each other to form agglomerates and couples particles and agglomerates to the scaffold.
Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of using scaffolds for treating degenerative tissue disorders.
|Membrane-scaffold composites for tissue engineering applications|
Collagen-glycosaminoglycan membrane shell scaffold core composites for connective tissue engineering that avoids aspects of the typical tradeoff between mechanical properties (i.e. Modulus, failure strength) and bioactivity (i.e., permeability and porosity) for porous tissue engineering scaffolds.
|Biodegradable vascular grafts|
Disclosed herein are biodegradable scaffolds for in situ tissue engineering. In some examples, biodegradable vascular grafts and methods of fabricating and uses of such are disclosed.
An object is to surely hold a stent formed of a biodegradable polymer and shape memorized to an expanded size having a diameter larger than an inner diameter of a vessel on a balloon in contracted state. A stent apparatus comprises a stent formed of a biodegradable polymer material using polylactic acid having a shape memory property as a tubular shape and shape memorized to a size capable of scaffolding a vessel from the inside when implanted in the vessel; and a stent holding member formed of a biodegradable polymer material for covering the outer surface of the stent to hold the stent in a contracted state that is smaller in diameter than the shape memorized size, wherein a stent detecting member is attached to the stent and a part of the stent holding member is fixed to the stent detecting member..
|Fibronectin based scaffold domain proteins that bind to myostatin|
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, copd, chronic kidney disease, heart failure, myocardial infarction, and fibrosis.
|Systems and methods for capture and sequestration of gases and compositions derived therefrom|
A composition is produced by a hydrothermal liquid phase sintering process, and the process includes providing a porous matrix, the porous matrix having a shape, and allowing a component of the porous matrix to undergo a reaction with an infiltrating medium to form a first product, the infiltrating medium including a greenhouse gas, a remainder of the porous matrix acting as a scaffold for facilitating the formation of the first product. The composition includes the first product and the reminder of the porous matrix.
|Injectable silk fibroin particles and uses thereof|
The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection) and/or be molded flexibly into a tissue void of any shape and/or size.
|Method for selecting a candidate drug compound|
The disclosure relates to the field of candidate drug testing and drug development. A method is provided for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, the method comprising providing a scaffold comprising at least a first and a second reactive group; providing at least one molecule capable of reacting with the at least first and second reactive group; contacting the scaffold with at least one molecule to form at least two linkages between the scaffold and the at least one molecule in a coupling reaction, wherein the formation of a linkage accelerates the formation of a consecutive linkage, preferably wherein the coupling reaction is performed in solution, more preferably in an aqueous solution.
|Inorganic fibrous membrane and a method of fabricating thereof|
A method of fabricating an inorganic fibrous membrane, the method comprising the steps of: grafting sulfonated graphene oxide onto a scaffold of inorganic nanofibers to form a suspension of heterojunctions of the sulfonated graphene oxide and the scaffold; filtering the suspension through a support to obtain heterojunctions on the support; drying the heterojunctions on the support; and removing the support to obtain the inorganic fibrous membrane.. .
|Mobile scaffolding units with extendible gantry platform and methods of using same|
Mobile scaffolding units include a vehicle for movement across ground surface, a stationary platform rigidly fixed to the vehicle at a predetermined immovable height above the ground surface, and a gantry platform operatively connected to the stationary platform for movements between a retracted position where the gantry platform is nested adjacent to the stationary platform, and an extended position wherein the gantry platform extends laterally outwardly from one or another lateral side of the stationary platform to provide an operator on the gantry platform an extended horizontal reach laterally of the vehicle. The mobile scaffolding units allow an operator to work at elevated heights and with lateral reach in one area of a work zone (e.g., to trim roadside vegetation) and then move to another area of the work zone without requiring an operator to dismount from the gantry platform..
|Constructing method for concrete cylinder of construction steel bar of high-rise steel structure|
A constructing method for a concrete cylinder of a construction steel bar of a high-rise steel structure adopts a constructing method of supporting inside and climbing outside. The outside of the cylinder adopts hydraulic mutual-climbing adhesive lifting scaffold creeping formwork system (100), and also has an outside wallboard mechanical formwork erection function and an outer frame protection function.
|Synthesizing functionalized dendrimers within biological settings|
The present invention relates to compositions (e.g., dendrimer scaffolds) capable of click chemistry for use in synthesis of functionalized dendrimers within biological settings, and methods of use of the same.. .
|Cell culture assay|
The present invention relates to a cell culture assay. The present invention comprises: a substrate; a scaffold channel which is formed along the centre inside the substrate, and of which at least one is disposed continuously, and inside which a scaffold flows; and a microfluidic channel or channels which is/are respectively formed on one side or on both sides of the scaffold channel, and inside which cells flow, and, here, a leak-preventing part for preventing the scaffold from leaking into the microfluidic channel(s) is formed in at least one of the ceiling surface and the floor surface of a boundary part of the scaffold channel and the microfluidic channel(s)..
|Panel and use of such a panel as a scaffolding board or a building panel|
The present invention relates to a panel comprising two parallel skin plates made of wood or a wood material, between which ribs extend for stiffening the panel, wherein the ribs are at least substantially made of wood or a wood material. The present invention further relates to the use of such a panel as a scaffolding board or a construction element and to scaffolding provided with such panels..
|Methods of coating a construct with methylated collagen|
A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold.
|Multi-layered injectable self-assembling peptide scaffold hydrogels for long-term sustained release of human antibodies|
The invention relates to a pharmaceutical formulation for sustained delivery of a therapeutic agent, preferably a protein, polypeptide, an antibody or an antibody fragment, comprising one or more gel forming peptides wherein the formulation exhibits sustained delivery for at least two weeks, three weeks, four weeks, five weeks, six weeks, seven weeks, eight weeks, nine weeks, ten weeks, eleven weeks, twelve weeks or more. In one embodiment, the invention relates to a formulation comprising self-assembling peptides that undergo sol-gel transition in the presence of an electrolyte solution such as biological fluids and salts.
|Tissue products including a temperature change composition containing phase change components within a non-interfering molecular scaffold|
Wiping products, such as facial tissues, contain a temperature change composition that can provide a cooling sensation when contacted with the skin of a user. The temperature change composition includes a phase change material and a non-interfering molecular scaffold.
|Compositions and methods for dental tissue regeneration|
Provided is a method for regenerating dental tissue, which can include contacting a scaffold containing wnt3a and bmp-7, and optionally vegf, bfgf, or ngf, with a dental tissue so as to promote odontoblastic differentiation of a progenitor cell, promote progenitor cell migration into the dental tissue, or regenerate the dental tissue. Also provided is a composition for regeneration of dental tissue, which can include a scaffold and wnt3a and bmp-7, and optionally vegf, bfgf, or ngf..
|Magnetic field-controlled movable bio-scaffold and constructing method thereof|
Disclosed are a magnetic field-controlled movable bio-scaffold and a method for constructing the same. The bio-scaffold is highly biocompatible and can readily move to a target site under the control of an external magnetic field..
|Dual latching horizontal scaffold member|
One embodiment of the invention is a horizontal scaffold member having a primary end connector and a secondary end connector. Each end connector is configured to couple to a cup on a vertical scaffold member.
|Membrane-type artificial scaffold and method for fabricating same|
Provided herein are a membrane-type artificial scaffold for guided bone regeneration (gbr) and a method for fabricating the same. The membrane-type artificial scaffold according to the present invention comprises: a first layer made of at least one fiber layer arranged in parallel with each other with a first spacing therebetween such that the fiber layer contacts a bone tissue in vivo; and a second layer stacked on the first layer and made of at least one fiber layer arranged parallel to each other with a second spacing therebetween such that the fiber layer contacts a soft tissue in vivo.
|Monolithic medical devices, methods of making and using the same|
The monolithic device comprises a plurality of scaffolding members and a mesh patterned members webbed between the scaffolding members; the mesh patterned member webbed between the scaffolding members surround a lumen and generally expands from a contracted state to an expanded state; and mesh patterned members including a plurality of openings traversing the thickness of the mesh patterned member, and the mesh patterned members including a surface on which a pattern of openings is formed.. .
|Device and method for deploying and attaching an implant to a biological tissue|
This present invention generally relates to devices and methods for repairing an aperture in a biological tissue. In certain embodiments, the invention provides a system for closing an aperture in a biological tissue including a handle, an elongate shaft connected to the handle, and a deployment scaffold connected to the shaft, in which the scaffold is configured to releasably retain a surgical implant and the scaffold is configured to deploy and attach the surgical implant to the biological tissue..
|Occlusion device for closing anatomical defects|
An occlusion device for closing an anatomical defect in tissue comprising a conduit connecting an opening on a first tissue and an opening on a second tissue is provided. The occlusion device comprises a scaffold comprising a) a proximal support structure comprising at least two arms; b) a distal support structure comprising at least two arms, wherein the arms are adapted to provide anchorage for the device in the tissue; and c) a waist portion adapted for extending through the opening on the first tissue and connecting the proximal support structure with the distal support structure, wherein the scaffold consists essentially of a biodegradable polymer, wherein the proximal support structure and the distal support structure comprise or consist of polycaprolactone (pcl), poly-(d,l-lactide-co-caprolactone) (plc), or a mixture thereof.
|Preparation of regenerative tissue scaffolds|
Devices and methods for treating or repairing a tissue or organ defect or injury are provided. The devices can include tissue scaffolds produced from acellular tissue matrices and polymers, which have a stable three-dimensional shape and elicit a limited immunologic or inflammatory response..
|Modified human plasma polypeptide or fc scaffolds and their uses|
Modified human plasma polypeptides or fc and uses thereof are provided.. .
|Method for selecting a candidate drug compound|
The disclosure relates to the field of candidate drug testing and drug development. Described are methods for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, the method comprising providing a scaffold comprising at least a first and a second reactive group; providing at least one molecule able to react with the at least first and second reactive group; and contacting the scaffold with at least one molecule to form at least two linkages between the scaffold and the molecule in a coupling reaction, wherein the formation of a linkage accelerates the formation of a consecutive linkage.
|Implantable embolic scaffolds that promote healing|
Implant devices and structures that reduce inflammation and promote healing of the area of implant. Specifically, the use of shape memory open cell biocompatible polymer foams for implants that assist in and promote healing and especially in filling and sealing aneurisms..
|Biodegradable bone fillers, membranes and scaffolds containing composite particles|
This invention is related to bone fillers, hard tissue supporting films and three dimensional scaffolds that contains composite particle of inorganic compound/water soluble polymer (such as β-tcp/gelatin), that can lead to bone regeneration and release an antibacterial or bioactive agent at the defect area. The bone regenerative hard tissue supporting films and scaffolds were obtained by addition of antibacterial or bioactive agent loaded composite particles into biodegrable polymer (such as pcl) matrix..
The present invention describes novel immunoglobulin compositions that co-engage at least two antigens, e.g. A first and second antigen, or, as outlined herein, three or four antigens can be bound, in some of the scaffold formats described herein.
|Alimentary protein-based scaffolds (aps) for wound healing, regenerative medicine and drug discovery|
The invention provides engineered biomaterials derived from plant products. The engineered biomaterials are useful for biomedical applications.
|Implantable scaffolds and methods of use|
Inventive concepts relate general to the field of implantable three-dimensional scaffolds. More particularly, methods of preparing and using implantable nanofibrous tissue scaffolds are described.
|Lsr antibodies, and uses thereof for treatment of cancer|
This invention relates to antibodies and antigen binding fragments and conjugates containing same, and/or alternative scaffolds, specific for lsr molecules, which are suitable drugs for immunotherapy and treatment of specific cancer.. .
|Multifunctional small molecules|
The present invention relates to dendrimer synthesis. Specifically, the present invention relates to dendrimer compositions (e.g., scaffolds) capable of copper-free click conjugation for use in the synthesis of functionalized dendrimers, and methods of use of the same..
|Surface-functionalized mesoporous carbon materials|
A functionalized mesoporous carbon composition comprising a mesoporous carbon scaffold having mesopores in which polyvinyl polymer grafts are covalently attached, wherein said mesopores have a size of at least 2 nm and up to 50 nm. Also described is a method for producing the functionalized mesoporous composition, wherein a reaction medium comprising a precursor mesoporous carbon, vinyl monomer, initiator, and solvent is subjected to sonication of sufficient power to result in grafting and polymerization of the vinyl monomer into mesopores of the precursor mesoporous carbon.
|Bone tissue engineering by ex vivo stem cells ongrowth into three-dimensional trabecular metal|
Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue..
The present disclosure relates to a tissue collection apparatus including a housing defining an inlet and an outlet and a tissue scaffold suitable for disposal within the housing, the tissue scaffold configured to be loaded with the tissue under the application of an aspiration force applied through the tissue collection apparatus.. .
|Cyclopropenimine catalyst compositions and processes|
The present invention provides, inter alia, a cyclopropenimine brønsted base catalyst and a cyclopropenimine scaffold for use as a brønsted base catalyst. This cyclopropenimine has the structure (100).
|Incorporation of plant virus particles and polymers as 2d and 3d scaffolds to manipulate cellular behaviors|
Methods are generally disclosed for attaching a cell binding motif to a carboxy end of a coat protein of a tobacco mosaic virus particle to form a modified-tmv particle; and attaching a cell to the cell binding motif of the modified-tmv particle.. .
|Nanoparticle-based scaffolds and implants, methods for making the same, and applications thereof|
Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs.
|Solid forms for tissue repair|
This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.. .
|Degradation-stabilised, biocompatible collagen matrices|
The present invention relates to degradation-stabilised, biocompatible collagen matrices which are distinguished in particular by the fact that they contain soluble collagen and peptide constituents, to processes for the preparation of such collagen matrices, which processes include in particular chemical crosslinking with an epoxy-functional crosslinking agent, and to the use of the collagen matrices according to the invention as a cosmetic or pharmaceutical agent, in particular for topical use, and as a wound treatment agent, as an implant or as a haemostatic agent in humans or animals, and as a scaffold for cell population in the biotechnology, basic research and tissue engineering field.. .
|Synthetic diblock copolypeptide hydrogels for use in the central nervous system|
This invention relates, e.g., to a composition suitable for administration to the central nervous system (cns), comprising a block copolypeptide hydrogel, which comprises a biologically active material that is mixed with the hydrogel or that is attached to the polypeptide chain of the hydrogel, wherein the composition is suitable for administration to the cns. Also disclosed are methods of making and using compositions of the invention as depots or as scaffolds for cell migration, and pharmaceutical compositions and kits for implementing methods of the invention..