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This page is updated frequently with new Scaffold-related patent applications. Subscribe to the Scaffold RSS feed to automatically get the update: related Scaffold RSS feeds. RSS updates for this page: Scaffold RSS RSS


Pegylated fibrinogen precursor molecule

Orbusneich Medical

Bioabsorbable polymeric medical device

Date/App# patent app List of recent Scaffold-related patents
01/29/15
20150032221
 Bone repair material patent thumbnailnew patent Bone repair material
Sliceable bone repair material is a porous block-shaped scaffold containing a hydrogel, wherein the hydrogel is formed by michael type addition of at least two precursor molecules. Said scaffold is made of a synthetic ceramic material and has interconnected macropores having a diameter above 100 μm.
Straumann Holding Ag
01/29/15
20150032200
 Bioabsorbable polymeric medical device patent thumbnailnew patent Bioabsorbable polymeric medical device
In embodiments there is described a cardiovascular tube-shaped lockable and expandable bioabsorbable scaffold having a low immunogenicity manufactured from a crystallizable bioabsorbable polymer composition or blend.. .
Orbusneich Medical, Inc.
01/29/15
20150031131
 Tissue-engineered constructs patent thumbnailnew patent Tissue-engineered constructs
The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit.
Humacyte
01/29/15
20150030688
 Honey and growth factor eluting scaffold for wound healing and tissue engineering patent thumbnailnew patent Honey and growth factor eluting scaffold for wound healing and tissue engineering
Tissue engineering structures with biologically favorable structural and chemical properties are disclosed. More particularly, the present disclosure is directed to tissue engineered scaffolds having a fiber support and honey.
Saint Louis University
01/29/15
20150030658
 Generation of photoreceptors from human retinal progenitor cells using polycaprolactone substrates patent thumbnailnew patent Generation of photoreceptors from human retinal progenitor cells using polycaprolactone substrates
The present invention relates to biocompatible compositions for transplantation into a sub-retinal space of the human eye. The compositions include a biodegradable polyester film, preferably a polycaprolactone (pcl) film, and a layer of human retinal progenitor cells.
The Schepens Eye Research Institute
01/29/15
20150030657
 Smooth muscle cell constructs patent thumbnailnew patent Smooth muscle cell constructs
The present invention relates to the regeneration, reconstruction, augmentation or replacement of luminal organs or tissue structures in a subject in need using scaffolds seeded with autologous or non-autologous cell populations that are or are not derived from the corresponding organ or tissue structure that is the subject of the regeneration, reconstruction, augmentation or replacement.. .
Tengion, Inc.
01/29/15
20150030655
 Plga scaffold patent thumbnailnew patent Plga scaffold
Disclosed is a plga (poly(d,l-lactide-co-glycolide)) cell scaffold. The cell scaffold is based on a plga scaffold, which is an fda-approved material with no cytotoxicity, and overcomes the problem with conventional plga scaffolds of poor cell adhesion..
Daegu Gyeongbuk Institute Of Science And Technology
01/29/15
20150030580
 Pegylated fibrinogen precursor molecule patent thumbnailnew patent Pegylated fibrinogen precursor molecule
The present invention relates to biodegradable scaffolds composed of a naturally-occurring protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides pegylated-fibrinogen scaffold and methods of generating and using same for treating disorders requiring tissue regeneration..
Regentis Biomaterials Ltd.
01/22/15
20150025651
 Bone repair material patent thumbnailBone repair material
Sliceable bone repair material is a porous block-shaped scaffold containing a hydrogel, wherein the hydrogel is formed by michael type addition of at least two precursor molecules. Said scaffold is made of a synthetic ceramic material and has interconnected macropores having a diameter above 100 μm.
Straumann Holding Ag
01/22/15
20150025311
 Small single-port arthroscopic lavage, directed tissue drying, biocompatible tissue scaffold and autologous regenerated cell placement delivery system patent thumbnailSmall single-port arthroscopic lavage, directed tissue drying, biocompatible tissue scaffold and autologous regenerated cell placement delivery system
A system for performing arthroscopic lavage, directed tissue drying, and the accurate placement of a biocompatible tissue scaffold for the adherence of autologous regenerated cells through a small single port of entry into a joint compartment. The system is comprised of a handpiece having valves for irrigation and suctioning and a dual valve swivel cannula attached to the handpiece.
01/22/15
20150025009

Collagen and fibrin microthreads in a discrete thread model of in vitro acl scaffold regeneration


Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., rgd-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells.
Worcester Polytechnic Institute
01/22/15
20150024967

Three-dimensional fibrous scaffolds for cell culture


Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (peg-pla) and a poly(lactic-co-glycolic acid) (plga). Also provided are methods for using the three-dimensional scaffolds described herein..
University Of South Florida (a Florida Non-profit Corporation)
01/22/15
20150024376

Trap and flow system and process for capture of target analytes


A magnetizable trap and flow system and process are detailed that uniformly disperse paramagnetic or superparamagnetic analyte capture beads within a scaffold of magnetizable beads or other magnetizable materials in a capture zone that provides selective capture of target analytes. A magnet placed or energized in proximity to the trap may magnetize the magnetizable scaffold and secure the paramagnetic or superparamagnetic analyte capture beads in their uniformly dispersed state within the magnetizable scaffold to provide selective capture of target analytes..
Battelle Memorial Institute
01/22/15
20150024063

Multi-phased, biodegradable and oesteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue to bone


Methods and apparatuses are provided for musculoskeletal tissue engineering. For example, a scaffold apparatus is provided which comprises microspheres of selected sizes and/or composition.
The Trustees Of Columbia University In The City Of New York
01/22/15
20150024026

Scaffolds for cell transplantation


A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material..
President And Fellows Of Harvard College
01/22/15
20150023726

Scaffold mount bracket


A scaffold mount bracket having an upper horizontal mount member, a wedge head, a lower horizontal mount member, a clamp, a vertical mount member, the vertical mount member having coupled proximate to the upper end thereof, and orthogonally thereto, the upper horizontal mount member and coupled to a lower end of the vertical mount member, and orthogonally thereto, the lower horizontal mount member. Coupled to the top of the vertical mount member is an attachment member having an aperture or structure for receiving, either directly or indirectly, a cable for hoisting or lowering a scaffold to which the invention is mounted or for hoisting or lowering a separate scaffold member or structure.
Saferite Platforms, Inc.
01/22/15
20150021119

Self-launching movable scaffolding system


A self-launching movable scaffolding system comprising: a main girder which transfers loads to supports; a front nose which transfers load of the system to support during launching; a rear nose which transfers load to a rear support during casting and launching, which is equipped with a rail system; hanger trusses which transfer load from a formwork to the main girder during casting; a rear support which provides support to the system during rebar cage installation, casting, and launching; a front support which provides support to the system during rebar cage installation and casting; a front and a middle launching support which provide support to the system during launching; a launching wagon for providing support and movement of the system; a trolley system which provides relocation to the front and middle launching supports and provides rebar cage delivery; and a formwork which is a mold for forming concrete to a shape.. .
Nrs Consulting Co., Ltd.
01/15/15
20150018968

Method for creating an internal transport system within tissue scaffolds using computer-aided tissue engineering


An artificial tissue including an internal mass transport network having a plurality of channels, wherein the channels are designed to substantially mimic naturally occurring vascular network and a method for creating an internal transport system within a tissue scaffold to improve circulation, diffusion, and mass transport properties by utilizing computer-aided tissue engineering (cate). The artificial tissue has the internal mass transport network of channels embedded, deposited, or molded within a scaffold, wherein the channels are made from a biodegradable transporting material and the scaffold is made from a scaffold material.
Drexel University
01/15/15
20150018966

Decellularisation of tissue matrices for bladder implantation


The invention provides an improved method of producing a natural, acellular matrix scaffold for subsequent use in tissue-engineered replacement of tissues such as the bladder. Decellularisation is carried out on an expanded or distended bladder and the product retains the strength and compliance of natural material.
Tissue Regenix Limited
01/15/15
20150018539

Modified mirna as a scaffold for shrna


What is described is a modified mirna molecule for producing an artificial sirna/mature small rna molecule that inhibits the expression of a target transcript of a host cell, comprising a stem region modified to comprise a sequence encoding the artificial sirna molecule, consisting of a guide and a passenger strand; a conserved region having specific sequences; and a nonconserved region modified to include a recognition site for a restriction enzyme while preserving the native secondary structure of the mirna. The modified mirna molecule produced with these elements substantially inhibits the expression of the target transcript when expressed from an endogenous or exogenous promoter in the host cell..
Mirimus, Inc.
01/15/15
20150018340

Pipecolate-diketoamides for treatment of psychiatric disorders


The present invention relates to compounds having a pipecolate diketoamide scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said pipecolate diketoamide compounds can be used for prophylaxis and/or treatment of psychiatric disorders and neurodegenerative diseases, disorders and conditions..
Max-planck-gesellschaft Zur FÖrderung Der Wissenschaften E.v.
01/15/15
20150017861

Collagen scaffold for cell growth and a producing same


A bioscaffold and method of manufacture is described. The bioscaffold has greater than 80% type i collagen fibers or bundles having a knitted structure providing tensile load strength.
The University Of Western Australia
01/15/15
20150017720

Therapeutic uses of curcumin analogs for treatment of prostate cancer


This invention relates generally to methods of treating aggressive cancers, such as hormone-refractory metastatic prostate cancer, by exposing the aggressive cancer cells to curcumin analogs having the claimed structural scaffolds and side groups. The anticancer effects of curcumin are associated with its influence on numerous growth factors within the cells.
California State University Fresno
01/15/15
20150017444

Rational assembly of nanoparticle superlattices with designed lattice symmetries


A method for lattice design via multivalent linkers (ldml) is disclosed that introduces a rationally designed symmetry of connections between particles in order to achieve control over the morphology of their assembly. The method affords the inclusion of different programmable interactions within one linker that allow an assembly of different types of particles.
Brookhaven Science Associates, Llc
01/15/15
20150017225

Hemostatic pad assembly kit and method


The present invention relates generally to agents and devices for promoting hemostasis and tissue sealing and, more particularly, to hemostatic pads comprising bioabsorbable scaffolds that can deliver lyophilized hemostasis promoting proteins, such as fibrinogen and thrombin, to a wound site or injured organ or tissue.. .
Ethicon, Inc.
01/15/15
20150017140

Organoids comprising decellularized and repopulated placental vascular scaffold


Provided herein are organoids comprising decellularized placental vascular scaffold comprising, or consisting of, a decellularized placental vascular scaffold, and methods of making and using the same.. .
Anthrogenesis Corporation
01/15/15
20150014096

High capacity vertical member for use with modular scaffolding


A vertical member of a modular scaffolding system includes a securing rosette provided in an upper section having a reduced diameter to provide a pre-determined modular connection. The vertical member includes an elongate intermediate section forming the majority of the vertical member of a first diameter greater than the reduced diameter.
01/15/15
20150014094

Ladder accessory holder extension


The invention is an accessory holder that may be attached to the leg of a support structure such as a ladder or scaffold. The accessory holder may have an attachment member for attaching the accessory holder the leg of a support structure.
01/08/15
20150012083

Tubular tissue-engineered constructs


The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit.
Humacyte
01/08/15
20150011982

Devices and methods for effecting faster healing of orthopedic and other wounds


Disclosed are medical devices, e.g., surgical sutures, surgical staples, surgical pads, surgical meshes, surgical scaffolds etc., and methods of use at a wound in a patient to facilitate the rapid healing of the tissue at the situs of the wound with minimal fibrous tissue formation. The devices are arranged to be brought into engagement with tissue adjacent the wound to close the wound and include a core formed of a piezo-electric material and an outer layer covering the core.
01/08/15
20150011541

Pipecolate-sulfonamides for treatment of psychiatric disorders


The present invention relates to compounds having a pipecolate sulfonamide scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said pipecolate sulfonamide compounds can be used for prophylaxis and/or treatment of psychiatric disorders and neurodegenerative diseases, disorders and conditions..
Max-planck-gesellschaft Zur Förderung Der Wissenschaften E.v.
01/08/15
20150010919

Polysiloxane substrates with highly-tunable elastic modulus


A highly tunable bioscaffold is provided, as well as a method of manufacture of the bioscaffold and methods of use of the bioscaffold, for example for drug testing, cell propagation and for optimizing growth of a cell type, for example corneal endothelial cells.. .
University Of Pittsburgh - Of The Commonwealth System Of Higher Education
01/08/15
20150010607

Liquefaction of bone matrix


The invention relates to methods of preparing a bone matrix solution, a bone matrix implant, and variants thereof. The invention also relates to methods of cell culture using the same.
Lifenet Health
01/01/15
20150005709

Method of making a corrugated deflection diaphragm


A removable material is deposited or otherwise applied to a flat substrate surface in a pattern corresponding to desired corrugations in a membrane, e.g., a deflection diaphragm. The applied material serves as a scaffold for a polymeric material, which is applied thereover, and following cure or hardening, the polymeric material is removed to form a finished corrugated membrane..
01/01/15
20150004222

Methods for preparing cell delivery matrices


Cell delivery matrices and methods for facilitating local delivery of adipose derived endothelial cells to a target tissue, body cavity, or joint are described. The cell delivery matrix may be a three-dimensional matrix scaffold comprising fibrin derived from the patient's own body.
Tissue Genesis, Inc.
01/01/15
20150004199

Methods for in situ cell sodding


Cell delivery matrices and methods for facilitating local delivery of adipose derived endothelial cells to a target tissue, body cavity, or joint are described. The cell delivery matrix may be a three-dimensional matrix scaffold comprising fibrin derived from the patient's own body.
Tissue Genesis, Inc.
01/01/15
20150002990

Packaging structures of an energy storage device


The invention relates to a packaging structure of an energy storage device. At least one unit cell of capacitor is stacked and packaged into the energy storage device.
Feng Chia University
01/01/15
20150001006

Suspended scaffold cable diverter system


A suspended scaffold rigging system includes a base to be attached with a roof of a building and an arm attached with the base. The arm includes an end portion to extend over and away from an edge of the roof when the base is attached with the roof and a cable guide defined by the end portion.
Smithgroupjjr, Inc.
01/01/15
20150000561

Derivates based on hyaluronic acid, capable of forming hydrogels, preparation thereof, hydrogels based on said derivatives, preparation thereof and use


The invention relates to a new hyaluronan derivative according to the general formula (i), the method of preparation thereof, a hydrogel based on the new derivative, method of preparation of the hydrogel and the use of the hydrogel in tissue engineering, cosmetics, medicine or regenerative medicine, especially in the form of scaffolds for the treatment of articular cartilage or bone tissue defects.. .
Contipro Biotech S.r.o.
12/25/14
20140379083

Tubular bioengineered smooth muscle structures


Methods of generating tubular, bioengineered, smooth muscle structures are disclosed as well as bioengineered tissue for tubular organ repair or replacement. The methods can include the steps of obtaining smooth muscle cells; culturing the muscle cells to form a smooth muscle cell construct of directionally oriented smooth muscle cells; disposing the smooth muscle cell construct around a tubular scaffold; and culturing construct and scaffold in a growth media until a smooth muscle cell structure is achieved.
Wake Forest University Health Sciences
12/25/14
20140379072

Tissue-engineered vascular graft and its fabrication approach


Tissue-engineered vascular graft is designed to be used in cardiovascular surgeries, especially in coronary artery bypass grafting and peripheral vessels reconstruction procedures. Two-phase electrospinning technique was employed to fabricate a biodegradable polymer graft composed of the porous tubular scaffold supplemented by biologically active molecules, incorporated directly into the matrix walls in order to promote regeneration process of the patient's own vessel wall..
Fgbu "nii Kompleksnykh Problem Serdechno- Sosudistykh Zabolevany Sibirskogo Otdeleniya Ramn"
12/25/14
20140379065

Removable sheath assembly for a polymer scaffold


A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. A sheath is placed over the crimped scaffold after crimping to reduce recoil of the crimped polymer scaffold and maintain scaffold-balloon engagement relied on to hold the scaffold to the balloon when the scaffold is being delivered to a target in a body.
Abbott Cardiovascular Systems Inc.
12/25/14
20140379064

Protective sheath assembly for a polymer scaffold


A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. A sheath is placed over the crimped scaffold after crimping to reduce recoil of the crimped polymer scaffold and maintain scaffold-balloon engagement relied on to hold the scaffold to the balloon when the scaffold is being delivered to a target in a body.
Abbott Cardiovascular Systems Inc.
12/25/14
20140379012

Introducer sheaths, thrombus collection devices, and associated methods


A sheath comprises an elastomeric tube having a self-expanding scaffold coupled to a wall. The scaffold can expand to a diameter larger than the tube diameter to provide an enlarged distal opening.
Covidien Lp
12/25/14
20140378452

Treatment of neurodegenerative diseases through inhibition of hsp90


Treatment of neurodegenerative diseases is achieved using small molecule purine scaffold compounds that inhibit hsp90 and that possess the ability to cross the blood-brain barrier or are other wise delivered to the brain.. .
Sloan-kettering Institute For Cancer Research
12/25/14
20140378331

Multiplexed biomarker quantitation by nanopore analysis of biomarker-polymer complexes


Devices and methods for detecting a target molecule are provided herein. The methods entail contacting a sample with a polymer scaffold, the polymer comprising at least one association site configured to associate with the target molecule.
Two Pore Guys, Inc.
12/25/14
20140377863

Synthetic scaffolds and organ and tissue transplantation


A synthetic scaffold for replacing at least a portion of an airway includes an airway mold, one or more structural ribs on the airway mold, and a non-structural wall. Each of the one or more structural ribs is formed from a first material and the non-structural wall is formed from a second material.
Ucl Business Plc
12/25/14
20140377862

Cell cultivation method and cell culture


Provided is a cell cultivation method in which the cell is cultured using a peptide hydrogel as a scaffold, for carrying out high-dimensional culture of a cell such as porcine hepatocyte, human hepatocyte, porcine pancreatic islet or human pancreatic islet for a long period under conditions where cell survival, cell morphology and cell functions are maintained. Also provided are a cell culture including a cell and a peptide hydrogel obtained by the above-described cultivation method, a bioreactor including the cell culture, and a cell preparation including the cell culture..
National University Corporation Okayama University
12/25/14
20140377737

Method for culturing islet cells and preparing carrier for islet cell transplantation using atelocollagen, and artificial pancreas prepared using same


The present invention provides a method of culturing pancreatic islet cells using a cationized atelocollagen prepared by ionization of high purity atelocollagen, a method of preparing a carrier for pancreatic islet cell transplantation using a cationized atelocollagen, and an artificial pancreas prepared using the same. According to the present invention, it is possible to increase the viability and/or glucose-dependent insulin secretion of pancreatic islet cells during culture of the cells by the use of a cationized atelocollagen or crosslinked atelocollagen scaffold obtained by ionization of high purity atelocollagen.
University Of Ulsan Foundation For Industry Cooperation
12/25/14
20140377326

Fabrication of gelatin hydrogel sheet for the transplantation of corneal endothelium


The invention provides a corneal endothelial composition comprising a transparent hydrogel scaffold and a single layer of cultured corneal endothelial cells on the surface of the scaffold. The hydrogel scaffold i comprised of at least one biopolymer, preferably gelatin.
Wake Forest University Health Sciences
12/25/14
20140377232

Innervation of engineered structures


Methods of generating an innervated muscle structures are disclosed as well as bioengineered structures for tissue repair or regeneration. The methods can include the steps of obtaining populations of smooth muscle cells and neuronal progenitor cells and then seeding the cells together onto a matrix material, followed by culturing the seeded cells to form an innervated smooth muscle cell construct of directionally oriented smooth muscle cells.
Wake Forest University Health Sciences
12/25/14
20140377213

Wet-electrospun biodegradable scaffold and uses therefor


A cell growth matrix is provided that comprises a biodegradable elastomeric polymer electrodeposited concurrently with a sprayed or electrosprayed liquid that is a physiological solution or which comprises a mammalian blood product such as serum, plasma or platelet rich plasma. The matrix is useful as a cell-growth matrix and for repair of a tissue in a mammal, for instance by implantation in a mammal at a site in need of repair, such as in an abdominal wall..
University Of Pittsburgh - Of The Commonwealth System Of Higher Education
12/25/14
20140377209

Scaffolds formed from polymer-protein conjugates, methods of generating same and uses thereof


Conjugates are provided herein which comprise a protein attached to at least two polymeric moieties, at least one of which exhibits reverse thermal gelation. The conjugates are suitable for being cross-linked by non-covalent and/or covalent cross-linking.
Regentis Biomaterials Ltd.
12/25/14
20140374191

Crane boom access


Methods and apparatus access the boom (jib) of a crane, e.g. Of the type commonly employed on offshore oil rigs.
Conocophillips Company
12/25/14
20140374004

Tissue scaffold


A tissue scaffold includes a first film having a plurality of cell openings and a second film adjacent the first film and having a plurality of cell openings larger than the cell openings of the first film. The cell openings of the first film interconnect with the cell openings of the second film to define pathways extending through the first and second films..
Proxy Biomedical Limited
12/18/14
20140371712

Convection enhanced delivery apparatus, method, and application


An embodiment of the invention is directed to a microfabricated, silicon-based, convection enhanced delivery (ced) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening.
Cornell University
12/18/14
20140371395

Bioabsorbable blend for temporary scaffolding of the blood vessel wall


A bioabsorbable blend comprising poly(l-lactide) (plla) and a phosphorylcholine group-containing copolymer (ppcp) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete.
Suntech Co., Ltd.
12/18/14
20140371145

Scaffold for vascular endothelial cell migration


A scaffold for vascular endothelial cell migration includes a recombinant gelatin having an amino acid sequence derived from a partial amino acid sequence of collagen. A method for producing a blood vessel uses this scaffold..
Fujifilm Corporation
12/18/14
20140370595

Use of synthetic scaffolds for the production of biosynthetic pathway products


The present invention provides methods of producing a product or product precursor of a biosynthetic pathway in a genetically modified host cell. The present invention also provides genetically modified host cells comprising nucleic acids encoding a scaffold polypeptide and nucleic acids comprising nucleotide sequences encoding two or more enzymes in a biosynthetic pathway.
The Regents Of The University Of California
12/18/14
20140370508

A preparing biological material


This invention pertains to a method of preparing biological material from a biological sample selected from the group consisting of blood and sputum samples. The method includes the step of altering at least one constitutive characteristic of the biological sample in the presence of a capturing scaffold by adding a lysis buffer containing a solubilising agent and a detergent to the biological sample, for simultaneously inhibiting coagulation of the biological sample; lysing the biological sample to release the biological material from the biological sample, thus making the biological material available; and capturing at least one fraction of the biological material on the capturing scaffold..
North-west University
12/18/14
20140370116

Method and system for treatment of biological tissue


A composition for reconstruction, replacement or repair of damaged or diseased biological tissue comprising an extracellular matrix (ecm) composition that includes an ecm scaffold component and a bioactive agent component. In a preferred embodiment, the ecm scaffold component comprises mesothelial tissue and the bioactive agent comprises a statin..
12/18/14
20140370094

Silk-based scaffold platform for engineering tissue constructs


The inventions provided herein relate to silk-based scaffolds and methods of producing the same, which can be used for a range of tissue engineering applications. The fabrication methods described herein provide a versatile platform to incorporate hollow conduits (e.g., for nutrient/oxygen delivery) through three-dimensional silk-based scaffolds that have tunable bulk properties (e.g., but not limited to, porosity, mechanical, degradation rate) and allow endothelialization and/or cell compartmentalization, for engineering a variety of complex tissue equivalents..
Tufts University
12/18/14
20140369985

Removal of tumor cells from intraoperative autologous blood salvage


The invention relates to a method performed ex vivo for removal of tumor cells from intraoperatively collected blood salvage, to antibodies and scaffold proteins which mimic antibodies for use in said ex vivo method, to the use of said ex vivo method for removal of tumor cells from intraoperatively collected blood salvage followed by reintroducing the so obtained purified blood salvage or of concentrates of erythrocytes purified by said method to a patient from whom said intra-operatively collected blood was obtained, as well as to blood salvage or a concentrate of erythrocytes, both obtainable by said method for reinfusion to said patient.. .
Trion Pharma Gmbh
12/18/14
20140369975

Biomaterials comprising hyaluronic acid binding peptides and bifunctional biopolymer molecules for hyaluronic acid retention and tissue engineering applications


The present invention provides novel biomaterial compositions and methods having a technology to improve retention of hyaluronic acid (ha). The biomaterial compositions utilize small ha binding peptides that is tethered to synthetic biocompatible polymers.
The Johns Hopkins University


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Scaffold topics: Nucleotide, Recombinant, Polynucleotide, Amino Acid, Biodegradable, Encapsulation, Surfactant, Enhancement, Monoclonal Antibody, Polypeptide, Immunogenic, Amino Acid Sequence, Monoclonal, Interleukin 2, Immune Disease

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