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Scaffold patents



      

This page is updated frequently with new Scaffold-related patent applications.




Date/App# patent app List of recent Scaffold-related patents
07/21/16
20160207993 
 Antigen-binding constructs patent thumbnailAntigen-binding constructs
The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired vh/vl domain, methods of making such constructs and uses thereof.. .
Glaxo Group Limited


07/21/16
20160207984 
 High affinity synbodies for influenza patent thumbnailHigh affinity synbodies for influenza
Composition of synbodies that bind influenza. The synbodies are composed of two peptides joined on a scaffold..
Arizona Board Of Regents On Behalf Of Arizona State University


07/21/16
20160207979 
 Multivalent heteromultimer scaffold design and constructs patent thumbnailMultivalent heteromultimer scaffold design and constructs
Provided herein are multifunctional heteromultimer proteins. In specific embodiments is a heteromultimer comprising: at least two polypeptide constructs, each polypeptide construct comprising at least one cargo polypeptide attached to a transporter polypeptide, said transporter polypeptides derived from a monomeric native protein such that said monomeric constructs associate to form the heteromultimer and said transporter polypeptides associate to form a quasi-native structure of the monomeric native protein or analog thereof.
Zymeworks Inc.


07/21/16
20160206783 
 Cross-linked platelet material patent thumbnailCross-linked platelet material
This document provides methods and materials involved in making and using cross-linked platelet material (e.g., cross-linked lysate material from human platelets such as human platelets obtained from platelet blood collection preparations or platelet apheresis preparations). For example, methods and materials for cross-linking platelet material (e.g., lysate material obtained from human platelets) to form a matrix (e.g.
Mayo Foundation For Medical Education And Research


07/21/16
20160206780 
 Matrix scaffold for three-dimensional cell cultivation, methods of construction thereof and uses thereof patent thumbnailMatrix scaffold for three-dimensional cell cultivation, methods of construction thereof and uses thereof
This invention provides a matrix scaffold for three-dimensional (3d) cell cultivation, a method of its construction, and its uses. The matrix scaffold results from a crosslinking reaction of a fibroin-like substance prepared by a specific method from silk cocoons or filaments, chitosan and crosslinking agents.
Suzhou Cancercell Biotechnology Co. Ltd


07/21/16
20160206778 
 Composite support containing silk and collagen, and preparation method thereof patent thumbnailComposite support containing silk and collagen, and preparation method thereof
Embodiments of the present invention relate to a biodegradable scaffold for replacing tissue or inducing tissue regeneration and a preparation method thereof, wherein the scaffold comprises at least one woven silk tube layer and a collagen layer inside the tube layer. The scaffold is excellent in terms of tissue regeneration and mechanical properties and causes little or no immune response after implantation.
Dongguk University Industry-academic Cooperation Foundation


07/21/16
20160206753 
 Modularly assembled small molecules for the treatment of myotonic dystrophy type 1 patent thumbnailModularly assembled small molecules for the treatment of myotonic dystrophy type 1
To study rna function using small molecules, we designed bioactive, modularly assembled small molecules that target the noncoding expanded rna repeat that causes myotonic dystrophy type 1 (dm1), r(cug)exp. Different modular assembly scaffolds were investigated including polyamines, alpha-peptides, beta-peptides, and peptide tertiary amides (pt as).
The Scripps Research Institute


07/21/16
20160206745 
 Three dimensional soy protein-containing scaffolds and methods for their use and production patent thumbnailThree dimensional soy protein-containing scaffolds and methods for their use and production
Porous soy protein-based scaffolds and methods for making the scaffolds using 3d printing techniques are provided. Also provided are tissue growth scaffolds comprising the porous soy protein-based scaffolds and methods for growing tissue on the tissue growth scaffolds.
Northwestern University


07/21/16
20160206698 
 Use of compounds with thrombopoietic activity to promote bone growth and healing patent thumbnailUse of compounds with thrombopoietic activity to promote bone growth and healing
Tpo was used to promote the growth of bone in both rats and in mice. Gaps in both mouse and in rat bones were treated with a scaffold sized to fit the gap.
Indiana University Research & Technology Corporation


07/21/16
20160206692 
 Engineered integrin binding peptide compositions patent thumbnailEngineered integrin binding peptide compositions
Engineered peptides that bind with high affinity (low equilibrium dissociation constant (kd)) to the cell surface receptors of fibronectin (α5β1) or vitronectin (αvβ3 and αvβ5 integrins) are disclosed as useful as imaging tissue. These peptides are based on a molecular scaffold into which a subsequence containing the rgd integrin-binding motif has been inserted.
The Board Of Trustees Of The Leland Stanford Junior University


07/21/16
20160206439 

Stabilized, laterovertically-expanding fusion cage systems


An intervertebral scaffolding system is provided having a laterovertically-expanding frame operable for a reversible collapse from an expanded state into a collapsed state, the laterovertically-expanding frame having a stabilizer that slidably engages with the distal region of the laterovertically-expanding frame and is configured for retaining the laterovertically-expanding frame from a lateral movement that exceeds the expanded state. The expanded state, for example, can be configured to have an open graft distribution window that at least substantially closes upon the reversible collapse..
Ouroboros Medical, Inc.


07/21/16
20160206292 

Systems and methods for managing a patient


Implementations described and claimed herein provide systems and methods for managing one or more patients. In one implementation, an imaging window is determined based on a location of a probe.
Guardsman Scientific, Inc.


07/14/16
20160201341 

Dual latching horizontal scaffold member


One embodiment of the invention is a horizontal scaffold member having a primary end connector and a secondary end connector. Each end connector is configured to couple to a cup on a vertical scaffold member.
Next Generation Scaffold Services, Inc.


07/14/16
20160201095 

Methods for the site-selective introduction of halogen into natural products


Organohalides (e.g., organofluorides) represent a rapidly expanding proportion of molecules used in pharmaceuticals, diagnostics, agrochemicals, and materials. The present invention exploits the naturally occurring acetate condensation pathway as a means of introducing halogenated building blocks into natural product scaffolds.
The Regents Of The University Of California


07/14/16
20160201029 

Scaffold and implanting cells


The disclosure provides for a bone implant for replacing at least a portion of a bone of a patient. The bone implant includes a support structure being a non-antigenic porous natural collagen matrix configured to receive cells, the support structure formed by removing tissue and cells from a bone obtained from a body leaving only the non-antigenic collagen matrix, the support structure having a configuration corresponding to the configuration of the bone to be replaced, the support structure having a plurality of passages through which blood may flow.
P Tech, Llc


07/14/16
20160200773 

Molecule detection using boronic acid substituted probes


Provided are polymeric scaffold compositions and methods for detecting or quantitating diols such as carbohydrates or carbohydrate containing molecules (e.g., glycosylated protein). Provided herein are capture probes configured to bind to a scaffold.
Two Pore Guys, Inc.


07/14/16
20160200772 

Binding polypeptides having a mutated scaffold


The present disclosure relates to a class of engineered polypeptides and provides a polypeptide comprising the sequence ex2x3x4ax6x7eix10 x11lpnlx16x17x18qx20 x21 afix25x26lx28x29x30 px32qsx35x36llx39e akklx45x46x47q (seq id no: 55). The present disclosure also relates to populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the amino acid sequence ex2x3x4ax6x7eix10 x11 lpnlx16x17x18qx20 x21 afix25x26lx28x29x30 px32qsx35x36llx39e akklx45x46x47q (seq id no: 55), and methods for selecting a desired polypeptide having an affinity for a predetermined target from said population..
Affibody Ab


07/14/16
20160200043 

3-dimensional bioscaffolds


The invention concerns an apparatus and a method for the manufacture of a three-dimensional (3d) bioscaffold; a 3d bioscaffold made using same; and the use of said 3d bioscaffold in the manufacture of an implant to treat injuries such as, but not limited to, meniscal injuries.. .
National University Of Singapore


07/14/16
20160200035 

Scaffold having a shaped strut and methods for shaping scaffold struts


A scaffold strut is shaped to improve hemocompatibility. After laser cutting, the scaffold is placed on a work piece and its struts are shaped by flame polishing or brushing.
Abbott Cardiovascular Systems Inc.


07/14/16
20160199753 

Novel nanocomposites and their application as monolith columns


Novel materials for chromatographic separations, processes for their preparation, and separation devices containing the chromatographic materials. In particular, hybrid inorganic/organic monolith materials comprising a polymerized scaffolding nanocomposite (psn), wherein the nanocomposite contains a scaffolding functionality capable of chemically interacting with a surface of a second material are described.
Waters Technologies Corporation


07/14/16
20160199540 

Method for preparing an animal decellularized tissue matrix material and a decellularized tissue matrix material prepared thereby


A method for manufacturing an animal acellular tissue matrix material and a tissue matrix material manufactured by the same. The tissue matrix material manufactured by the method retains an original basic scaffold structure of a tissue extracellular matrix, with an antigen causing immunological rejection in a human body being effectively removed from the animal tissue.
Beijing Ruijian Gaoke Biotechnology Co., Ltd.


07/14/16
20160199538 

Collagen scaffold modified by covalent grafting of adhesion molecules, associated methods and use thereof for cardiovascular and thoracic cell therapy and contractile tissue engineering


Three-dimensional solid contractile collagen scaffolds having improved biological properties and electromechanical performance are provided. The scaffolds can be used for cell transplantation, including the fixation of biocompatible reagents and adhesion molecules which control cell adhesion, apoptosis, survival and/or differentiation simultaneously.

07/14/16
20160199536 

Photocrosslinkable poly(caprolactone fumarate)


Fumaric acid or a salt thereof, such as a fumaryl halide (e.g. Fumaryl chloride), which contains unsaturated carbon-carbon double bonds that can be used for in situ crosslinking, is copolymerized with poly(caprolactone) diol in the presence of an alkali metal salt.
Mayo Foundation For Medical Education And Research


07/14/16
20160199450 

Scaffolds containing cytokines for tissue engineering


The present disclosure provides biocompatible scaffold that promotes m1 or m2 macrophage phenotypes so as to increase vascularization or healing. Also provided are methods of treating a subject in need with the scaffolds described here..
The Trustees Of Columbia University In The City Of New York


07/07/16
20160194629 

Scaffolded nucleic acid polymer particles and methods of making and using


The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their volumes for higher loading capacities than those achievable solely with surface attachment.
Life Technologies Corporation


07/07/16
20160194593 

Perfusion bioreactor


In some embodiments the present invention provides perfusion bioreactors and cell culture scaffolds suitable for the preparation of tissue grafts, such as bone tissue grafts. In some embodiments, the perfusion bioreactors comprise a graft chamber and/or a graft chamber insert configured to hold a tissue graft having a certain shape and/or certain dimensions, and/or to allow culture of such tissue grafts under press-fit direct perfusion conditions.
New York Stem Cell Foundation, Inc.


07/07/16
20160194370 

Fusion protein of therapeutic polypeptide with improved pharmacokinetic profile and use therof


The present invention provides a fusion protein comprising a therapeutic polypeptide fused to one or more flexible unstructured polypeptides and a trimeric scaffold protein. The flexible unstructured polypeptide sequence within the fusion protein is exhibited as one or more pcloud sequences derived from human fibrinogen alpha chain, and may be flanked by a proteinous connecting moiety of human origin.
Beijing Anxinhuaide Biotech. Co., Ltd.


07/07/16
20160193384 

Transparent hydrogel and making the same from functionalized natural polymers


The present invention relates to a novel hydrogel derived from a methacrylated or acrylated natural polymer and a synthetic polymer, and a method of preparing the same. The invention further relates to 3d scaffolds and implants comprising said hydrogel..
Uab Ferentis


07/07/16
20160193382 

A flap for de-novo tissue regeneration


The present invention provides an implant which includes: (a) an autologous engineered tissue; and (b) a vasculature, wherein the engineered tissue is a porous scaffold embedded with endothelial cell, a fibroblast, a myoblast, a mesenchymal cell, an adipocyte, or any combination thereof, wherein the vasculature feeds the cells. Further, the invention provides a method for treating a subject afflicted with a large soft tissue defect by implanting the implant of the invention..
Health Corporation-rambam


07/07/16
20160193292 

Cell permeable inhibitors of the scaffold protein plenty of sh3 domains (posh) or sh3rfl


Plenty of sii3 (posh) and ink-interacting protein 1 (jip-1) function as a multi-protein scaffold network for tcr-mediated jnk1 activation in cd8+ t-cells. Disruption of the posh/jip-1 complex led to profound defects in the activation of jnk1, as well as deficient activation or induction of the transcription factors c-jun, t-bet and eomesodermin furthermore, disruption of the posh/jip complex in cd8+t-cells resulted in impaired proliferation, decreased cytokine expression and the inability to control tumors.
The Curators Of The University Of Missouri


07/07/16
20160193060 

Systems and methods for magnetized stent having growth-promoting properties


Embodiments relate to systems and methods for magnetized stent having growth-promoting properties. A stent assembly comprising a tubular elongated body having a magnetized region and a tissue nidus area is inserted beneath the orifice of a vascular aneurysm.
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.


06/30/16
20160186450 

Scaffold deck system with bracket-supported partial length planks for creating an opening to accommodate obstacles


A scaffold including a pair of scaffold frames has a scaffold platform supported by the frames, which is defined by a series of planks and includes an opening. The opening is formed by a pair of transverse support members that extend between the pair of planks at a location between the scaffold frames.

06/30/16
20160186393 

Cable-panel connector for bridge platform or other scaffolding


In another connector, the free end portion has a plurality of spaced grooves engageable by mating structure on the second plate for achieving the latched state. The mating structure comprises an elongate member in an inclined slot.

06/30/16
20160186156 

Artificial cellulosomes comprising multiple scaffolds and uses thereof in biomass degradation


Multi-enzyme complexes comprising an array of scaffold subunits designed for efficient integration of a plurality of carbohydrate-active enzymes are provided.. .

06/30/16
20160186131 

Three dimensional purified collagen matrices


Cell culture scaffolds presenting a more biologically relevant microenvironment are disclosed. More particularly, these cell culture scaffolds comprise three-dimensional matrices/biomaterials that are created from solubilized collagen compositions using controlled conditions to have the desired microstructure and mechanical properties.

06/30/16
20160184778 

Functionalization of nanofibrous microfiltration membranes for water purification


A high flux and low pressure drop microfiltration (mf) membrane and a method for making the mf membrane. The microfiltration membranes are formed by a method that includes: preparing a nanofibrous structure; and modifying the surface of the nanofibrous structure with a surface modifier.

06/30/16
20160184478 

Solubilization of antigen components for removal from tissues


The present invention relates to methods for removing antigens from tissues by sequentially destabilizing and/or depolymerizing cytoskeletal components and removing and/or reducing water-soluble antigens and lipid-soluble antigens. The invention further relates to tissue scaffolding and decellularized extracellular matrix produced by such methods..

06/30/16
20160184120 

Segmented scaffolds and delivery thereof for peripheral applications


Segmented scaffolds composed of disconnected scaffold segments are delivered to an implant site on a delivery balloon. The segments are crimped to the balloon and separated from each other by gaps.

06/30/16
20160184069 

High-strength biological scaffold material and preparation method thereof


A high-strength biological scaffold and preparation method thereof. The biological scaffold is comprised of a framework of boiled-off silk woven material, the form of the framework is determined by actual needs; the framework surface is coated with a layer of silk protein scaffold material, fibroin protein/gelatin biological scaffold material or fibroin protein/collagen biological scaffold material having a thickness of 100 micrometers to 5 centimeters.

06/30/16
20160184058 

Matrix for dental tissue regeneration


The present invention relates to a biomimetic matrix for providing structural support and scaffolding that allows for regeneration of dentin, pulp, and periodontal tissues. A method of making the biomimetic matrix provides the ability to select both a size of a pore or tubule formed in the biomimetic matrix and a density of pores or tubules disposed throughout the biomimetic matrix.

06/30/16
20160183808 

Methods, devices and systems for sensing, measuring and/or characterizing vessel and/or lesion compliance and/or elastance changes during vascular procedures


The present system is directed in various embodiments to methods, devices and systems for sensing, measuring and evaluating compliance and/or elastance in a bodily conduit. In other embodiments, the methods, devices and systems sense, measure, determine, display and/or interpret compliance and/or elastance in a bodily conduit and/or a lesion within the bodily conduit using fractional flow reserve and/or flow velocity measurements as well as resistance to flow calculations in certain embodiments.

06/30/16
20160183807 

Methods, devices and systems for sensing, measuring and/or characterizing vessel and/or lesion compliance and/or elastance changes during vascular procedures


The present system is directed in various embodiments to methods, devices and systems for sensing, measuring and evaluating compliance in a bodily conduit. In other embodiments, the methods, devices and systems sense, measure, determine, display and/or interpret compliance in a bodily conduit and/or a lesion within the bodily conduit.

06/23/16
20160177584 

Scaffold


Scaffolding unit to be attached to the deck structure of a bridge or similar comprises a set of arms for carrying working levels and the support structures needed in work and an attachment frame for attaching the set of arms to the upper surface of the deck structure. The set of arms is connected to the attachment frame by means of a pivoted parallelogram..

06/23/16
20160177583 

Modular roof mounted staging bracket with safety rails


An apparatus for supporting workers and materials above-grade on both the eave and gable ends of a structure is disclosed. The apparatus can be combined with one or more additional staging apparatuses to create a staging system for the support of persons or materials while work is being done on a structure, e.g., roofing, siding, etc.

06/23/16
20160177581 

Pivoting horizontal and vertical scaffold members and a erecting an offset scaffold platform


One embodiment of the invention is a horizontal scaffold truss that has upper and lower horizontal scaffold members offset but fixedly joined with braces. Each upper and lower members have a connector positioned on each end of the respective lower and upper members, where at least one of the connectors is pivotally mounted on the respective lower or upper connector, and the connectors are engageable with an annular member positioned on a vertical scaffold member..

06/23/16
20160176960 

Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for prevention or reduction of organ dysfunction or organ failure in a patient having a chronic disease or acute condition


Subject matter of the present invention is an anti-adrenomedullin (adm) antibody or an anti-adrenomedullin antibody fragment or an anti-adm non-ig scaffold for use in therapy of a chronical or acute disease or acute condition of a patient for prevention or reduction of organ dysfunction or organ failure. In a preferred embodiment subject matter of the invention is an anti-adm antibody or an anti-adrenomedullin antibody fragment or anti-adm non-ig scaffold for use in therapy of a chronical or acute disease or acute condition of a patient for prevention or reduction of kidney dysfunction or kidney failure or liver dysfunction or liver failure..

06/23/16
20160176934 

Ang-2 binding complexes and uses thereof


Complexes containing one or more modular recognition domains (mrds) and mrds attached to scaffolds including antibodies are described. The manufacture of these complexes are the use of these complexes to treat and diagnose diseases and disorders are also described..

06/23/16
20160176715 

Method and producing high purity phosgene


A reactor for producing phosgene, the reactor comprising: tube located in a shell and a space located between the tube and the shell; a cooling medium located in the space and a catalyst located in the tube or cooling medium located in the tube and a catalyst located in the space; a feed inlet; and a product mixture outlet; wherein the tube comprises one or more of: a mini-tube and a second tube section; a first concentric tube concentrically located in the shell; a twisted tube; an internal scaffold; and an external scaffold.. .

06/23/16
20160175493 

Modifying polymer properties with penetrants in the fabrication of bioresorbable scaffolds


Methods of fabricating a bioresorbable polymer scaffold are disclosed including a step of inducing crystallization in a bioresorbable polymer construct through exposure to a liquid penetrant.. .

06/23/16
20160175487 

Tissue repair scaffold and preparation method and purpose thereof


The present invention provides a tissue repair scaffold and a preparation method and purpose thereof. The tissue repair scaffold comprises at least one composite fiber layer, and the composite fiber layer comprises a composite fiber formed by an adhesion factor and a hydrophobic synthetic material.

06/23/16
20160175485 

Combination therapy to promote wound healing


Methods for increasing and/or promoting wound healing, wound re-epithelialization and dermal regeneration of epithelial tissues and cutaneous wounds by administration to a subject of an extracellular matrix scaffold or scaffold for dermal regeneration (sdr) populated with beta adrenergic receptor antagonist pre-conditioned mesenchymal stem cells (mscs) are provided. Compositions and kits comprising an extracellular matrix scaffold (ecms) populated with beta adrenergic receptor antagonist pre-conditioned mesenchymal stem cells (mscs) are also provided..

06/23/16
20160175482 

Composition and delivery system


An injectable agent delivery system comprising a composition that comprises: an agent for sustained delivery located within discrete particles; and an injectable scaffold material comprising discrete particles which are capable of interacting to form a scaffold, and uses thereof.. .

06/23/16
20160175480 

Solid forms for tissue repair


This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.. .

06/23/16
20160175458 

Single chain fc fusion proteins


The present invention provides novel, single chain fc fusion proteins having improved properties. The invention provides single chain fusions of soluble proteins fused to the fc region of an immunoglobulin via a novel linker comprising a constant region of an immunoglobulin light chain linked to a ch1 constant region of an immunoglobulin heavy chain.

06/23/16
20160175098 

Solid forms for tissue repair


This invention provides coral-based scaffolds for cartilage repair, and instruments for insertion and utilization of same within a site of cartilage repair.. .

06/16/16
20160169877 

Patterning silica islands onto thermoplastic shrink film


The disclosure relates to methods and devices for measuring samples, such as biological samples, especially those at low abundance, with high sensitivity and at low cost. A sample is disposed on a shrinkable scaffold and the shrinkable scaffold is shrunk, reducing the area where the sample is distributed, so as to effectively concentrate the sample on the surface of the scaffold.
The Regents Of The University Of California


06/16/16
20160168754 

Electrospinning producing multi-dimensional structures and core-sheath yarns


Electrospinning apparatus and method for producing multi-dimensional structures such as one-dimensional continuous yarns, two-dimensional mats and three-dimensional cotton-like fluffy scaffolds is disclosed. Further, electrospinning apparatus and method with single collector geometry for producing multi-dimensional structures and core-sheath yarns are disclosed..
Amrita Vishwa Vidyapeetham


06/16/16
20160168542 

Tissue engineered models of cancers


A 3d decellularized bone scaffold seeded with cancer cells, such as prostate cancer cells or ewing's sarcoma is provided. It provides platform technology for controllable, quantitative, long-term studies of tissue-engineered tumors, including prostate cancer and ewing's sarcoma.
The Trustees Of Columbia Unicersity In The City Of New York


06/16/16
20160168525 

Cell culturing method, particulate culture carrier, and particle-encompassing cell aggregate


Provided is a culturing method capable of causing a three-dimensional aggregate in which cell function is similar to in vivo function to adhere to a culturing vessel while improving permeability of nutrients, oxygen, drugs and reagents from the culture medium and maintaining cell function. By sowing isolated cells in a culturing vessel, and after the cells have settled on the culturing surface, administering microscaffold particles that are cell-adhesive and substance-permeable onto the cells, it is possible to cause the cells to adhere to the culturing vessel while forming cell aggregates that encompass the particles.
Hitachi High-technologies Corporation


06/16/16
20160167132 

Additive manufacturing of porous scaffold structures


Techniques for additive deposition are disclosed herein. In one embodiment, a method includes depositing a first portion of a precursor material onto a deposition platform, the precursor material including a suspension of nano-particles and forming a first solid structure of the nano-particles on the deposition platform from the deposited first layer of the precursor material.
Washington State University


06/16/16
20160166733 

Engineered neural tissue


A method for producing an engineered tissue scaffold for neural repair is described. The method includes tethering a hydrogel matrix seeded with tension-generating cells to a frame, and allowing the tension-generating cells to generate tension within the matrix, such that the cells self-align.
The Open University


06/16/16
20160166374 

Tubular vascular graft and the preparation thereof


The present invention provides a reparation method of a tubular vascular graft, (a) immersing a tubular scaffold in a first light sensitivity gelatin solution, and irradiate the tubular scaffold by a first time period, to let surface of the tubular scaffold form a base layer; (b) immersing the tubular scaffold of the step (a) in a chitin gelatin solution, when the surface of the base layer form a film, then immersing the tubular scaffold into a sodium hydroxide solution to generate a middle layer of the surface of the base layer; (c) immersing the tubular scaffold of the step (b) in a second light sensitivity gelatin solution, wherein the second light sensitivity gelatin solution comprises a cell, the tubular scaffold is irradiated by a second time period to form a surface layer of the middle layer; (d) until the cell forms a tubular structure of the surface layer by the cell in the tubular scaffold of the step (c), heating the tubular scaffold by a temperature to solve the base layer into a solution, pulling out the tubular scaffold to get an artificial blood vessels.. .
National Tsing Hua University


06/09/16
20160161453 

Stackable planar adsorptive devices


Adsorptive bed devices include a scaffold in housing having a stress absorbing rigid structure and open cells filled with adsorptive beads. The scaffold restricts movement of the plurality of adsorptive beads, absorbs stress induced by a hydraulic pressure gradient along a direction of liquid flow and transfers a portion of the induced compressive stress to the housing.
Spf Technologies Llc


06/09/16
20160161415 

Metal-antibody tagging and plasma-based detection


A target within a sample can be characterized using an energy source configured to transform a metal in the sample into a plasma and an optical spectroscopic detector configured to detect electromagnetic radiation emitted by the plasma to provide an optical-spectrum signal. A processor can determine presence of the metal in the sample using the optical-spectrum signal.
Purdue Research Foundation


06/09/16
20160160513 

Adjustable scaffold assembly


An adjustable scaffold assembly includes a pair of vertical supports. A pair of hand rails is provided.

06/09/16
20160160206 

Aldehyde-tagged protein-based drug carriers and methods of use


The disclosure provides aldehyde-tagged protein carriers that can be covalently and site-specifically bound to drug to provide a drug-containing scaffold. The invention also encompasses methods of production of such drug-containing scaffolds and intermediates, as well as methods of use..
Redwood Bioscience, Inc.


06/09/16
20160159954 

Polydendrons


A method of preparing a ph-responsive non-gelled branched vinyl polymer scaffold carrying dendrons, comprising the living or controlled polymerization of a mono functional vinyl monomer and a difunctional vinyl monomer, using a dendron initiator.. .
The Univeristy Of Liverpool


06/09/16
20160159940 

Polydendrons


A method of preparing a non-gelled branched vinyl polymer scaffold carrying dendrons, comprising the living or controlled polymerization of a monofunctional vinyl monomer and a difunctional vinyl monomer, using a dendron initiator and at least one further initiator.. .
The Univeristy Of Liverpool


06/09/16
20160159900 

Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for regulating the fluid balance in a patient having a chronic or acute disease


The present invention also provides a method for regulating the fluid balance in a patient having a chronic or acute disease or acute condition. Subject matter of the present invention is an anti-adrenomedullin adm antibody or anti-adm non-ig scaffold or an anti-adrenomedullin antibody fragment for use in therapy of a chronic or acute disease or acute condition of a patient for the regulation of fluid balance..

06/09/16
20160159883 

Fibronectin based scaffold domain proteins that bind pcsk9


The present invention relates to fibronectin based scaffold domain proteins that bind pcsk9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases.
Bristol-myers Squibb Company


06/09/16
20160159869 

Bmp-2-binding peptide amphiphile nanofibers


Provided herein are peptide amphiphiles with binding affinity for the bone promoting growth factor bmp-2, and methods of use thereof. In particular nanofibers and gel scaffolds of bmp-2-binding peptide amphiphiles are provided..
Northwestern University


06/09/16
20160159006 

Pneumatic manufacturing system for complex tissues and organs, having multiple degrees of freedom and multiple nozzles


Disclosed is a pneumatic manufacturing system for complex tissues and organs, having multiple degrees of freedom and multiple nozzles, belonging to the organs manufacturing field. The system comprises an x-direction movement mechanism, a y-direction movement mechanism, a q-direction rotation mechanism, a lifting platform, a rotation-forming platform, a shell, a high-pressure gas source, a multiple-nozzle forming unit, a spraying solution pressure tank, a temperature control device, a sterilizing device and a control unit.
Tsinghua University


06/09/16
20160158422 

Biodegradable supporting device


A biodegradable in vivo supporting device is disclosed. The in vivo supporting device comprises a biodegradable metal scaffold and a biodegradable polymer coating covering at least a portion of the biodegradable metal scaffold, wherein the biodegradable polymer coating has a degradation rate that is faster than the degradation rate of the biodegradable metal scaffold..
Q3 Medical Devices Limited


06/09/16
20160158416 

Scaffold for hard tissue regeneration containing active ingredient for treating osteoporosis and preparing method thereof


A scaffold for hard tissue regeneration comprising an active ingredient for treating osteoporosis and a preparation method thereof. The scaffold for hard tissue regeneration is prepared by the steps of mixing a polyphenol-based natural substance containing quercetein or genistein involved in the activation of osteoblasts and osteoclasts and the biofunctional analogue thereof with a ceramic scaffold material and molding the mixture at room temperature into a three-dimensional scaffold.
Korea Institute Of Machinery And Materials


06/09/16
20160158411 

Protein biomaterials and biocoacervates and methods of making and using thereof


The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention relates to protein biocoacervates and biomaterials that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, coated medical devices (e.g.
Gel-del Technologies, Inc.


06/09/16
20160158046 

Flow regulation valve for controlling inflation rate of a balloon deploying a scaffold


An apparatus and method for controlling inflation pressure, pressurization rate, and volumetric flow rate of a balloon during deployment of a stent or scaffold is disclosed.. .
Abbott Cardiovascular Systems Inc.


06/09/16
20160157992 

Tissue interface augmentation device for ligament/tendon reconstruction


The present invention relates to a device for the interfacial augmentation of tissue grafts for the purpose of tendon and ligament reconstruction. The inventive device works both as a delivery vessel for osteoconductive and osteoinductive factors and as a scaffold to stimulate and support bone ingrowth and comprises a tubular composite silk sheath, said tubular composite silk sheath comprising: a backbone consisting of a tubular silk mesh, and a carrier material consisting of a porous silk sponge, wherein said tubular silk mesh consists of degummed silk fibroin fibers, wherein said porous silk sponge comprises silk fibroin fibers and hydroxyapatite particles and said tubular silk mesh and said porous silk sponge form a composite material.
Agency For Science, Technology And Research


06/02/16
20160153205 

Scaffolding pipe of a structural scaffolding system and scaffolding element


A scaffolding pipe of a structural scaffolding system extends from a first axial pipe end to an opposing second axial pipe end. A receiving portion is provided on the first axial pipe end and an insertion portion is provided on the second axial pipe end.
Peri Gmbh


06/02/16
20160152766 

Polymer scaffold degradation control via chemical control


A variety of polymers and copolymers suitable for use as biologically compatible constructs and, as a non-limiting specific example, in the formation of degradable tissue scaffolds as well methods for synthesizing these polymers and copolymers are described. The polymers and copolymers have degradation rates that are substantially faster than those of previously described polymers suitable for the same uses.
Stc.unm


06/02/16
20160152686 

Fibronectin based scaffold domains linked to serum albumin or moiety binding thereto


Provided herein are fusion proteins comprising a first moiety comprising a fibronectin based scaffold and a second moiety comprising serum albumin or a biologically active fragment thereof or a serum albumin binding domain or a biologically active fragment thereof.. .
Bristol-myers Squibb Company


06/02/16
20160151762 

Formation of high surface area metal-organic frameworks


A metal-organic framework (mof) structure comprising at least one metal ion and at least one multidentate organic ligand which is coordinately bonded to said metal ion, and a scaffold.. .
Numat Technologies, Inc.


06/02/16
20160151546 

Biodegradable supporting device


A biodegradable in vivo supporting device is disclosed. The in vivo supporting device comprises a biodegradable metal scaffold and a biodegradable polymer coating covering at least a portion of the biodegradable metal scaffold, wherein the biodegradable polymer coating has a degradation rate that is faster than the degradation rate of the biodegradable metal scaffold..
Q3 Medical Devices Limited


06/02/16
20160151541 

Methods and devices for cellular transplantation


Devices and methods for transplanting cells in a host body are described. The cell comprises a porous scaffold that allows ingrowth of vascular and connective tissues, a plug or plug system configured for placement within the porous scaffold, and a seal configured to enclose a proximal opening in the porous scaffold.
Sernova Corporation


06/02/16
20160151540 

Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells


Provided herein are constructs of micro-aggregate multicellular, minimally polarized grafts containing leucine-rich repeat-containing g-protein coupled receptor (lgr) expressing cells for wound therapy applications, tissue engineering, cell therapy applications, regenerative medicine applications, medical/therapeutic applications, tissue healing applications, immune therapy applications, and tissue transplant therapy applications which preferably are associated with a delivery vector/substrate/support/scaffold for direct application.. .

06/02/16
20160151153 

Segmented transcatheter valve prosthesis having an unsupported valve segment


Embodiments hereof relate to a transcatheter valve prosthesis including a tubular fabric body, a first or inflow tubular scaffold attached to a first end portion of the tubular fabric body, and a second or outflow tubular scaffold attached to a second end portion of the tubular fabric body. A prosthetic valve component is disposed within and secured to an intermediate portion of the tubular fabric body that longitudinally extends between the first and second end portions of the tubular fabric body.
Medtronic, Inc.


05/26/16
20160145968 

Smart cellular structures for composite packer and mill-free bridgeplug seals having enhanced pressure rating


A smart device includes a scaffold that responds to an applied stimulation and an encapsulating structure that encapsulates the scaffold. The scaffold is formed from at least one smart material that responds to the applied stimulation.
Schlumberger Technology Corporation


05/26/16
20160145574 

Kit and promoting mesenchymal stem cell differentiation


The present invention is related to a kit comprising: (a) a mesenchymal stem cell; (b) a gelatin-hyaluronan-chondroitin tri-copolymer scaffold; (c) a kartogenin; and (d) a bioreactor. The present invention is also related to a method for promoting differentiation of a mesenchymal stem cell into cartilage tissue, comprising: (a) culturing the mesenchymal stem cell on a gelatin- hyaluronan-chondroitin tri-copolymer scaffold in the presence of a kartogenin; and (b) culturing the mesenchymal stem cell and the gelatin-hyaluronan-chondroitin tri-copolymer scaffold in a bioreactor..
National Taiwan University


05/26/16
20160145193 

Dual site catalyst for mild, selective nitrile reduction


A ruthenium bis(pyrazolyl)borate scaffold that enables cooperative reduction reactivity in which boron and ruthenium centers work in concert to effect selective nitrile reduction is provided. The pre-catalyst compound [κ3-(1-pz)2hb(n═chch3)]ru(cymene)− tfo− (pz=pyrazolyl) was synthesized using readily-available materials through a straightforward route, thus making it an appealing catalyst for a number of reactions..
University Of Southern California




Scaffold topics: Nucleotide, Recombinant, Polynucleotide, Amino Acid, Biodegradable, Encapsulation, Surfactant, Enhancement, Monoclonal Antibody, Polypeptide, Immunogenic, Amino Acid Sequence, Monoclonal, Interleukin 2, Immune Disease

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