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This page is updated frequently with new Scaffold-related patent applications. Subscribe to the Scaffold RSS feed to automatically get the update: related Scaffold RSS feeds. RSS updates for this page: Scaffold RSS RSS


Scaffold end cover system and method

Scaffold end cover system and method

Date/App# patent app List of recent Scaffold-related patents
12/18/14
20140371712
 Convection enhanced delivery apparatus, method, and application patent thumbnailnew patent Convection enhanced delivery apparatus, method, and application
An embodiment of the invention is directed to a microfabricated, silicon-based, convection enhanced delivery (ced) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening.
12/18/14
20140371395
 Bioabsorbable blend for temporary scaffolding of the blood vessel wall patent thumbnailnew patent Bioabsorbable blend for temporary scaffolding of the blood vessel wall
A bioabsorbable blend comprising poly(l-lactide) (plla) and a phosphorylcholine group-containing copolymer (ppcp) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete.
12/18/14
20140371145
 Scaffold for vascular endothelial cell migration patent thumbnailnew patent Scaffold for vascular endothelial cell migration
A scaffold for vascular endothelial cell migration includes a recombinant gelatin having an amino acid sequence derived from a partial amino acid sequence of collagen. A method for producing a blood vessel uses this scaffold..
12/18/14
20140370595
 Use of synthetic scaffolds for the production of biosynthetic pathway products patent thumbnailnew patent Use of synthetic scaffolds for the production of biosynthetic pathway products
The present invention provides methods of producing a product or product precursor of a biosynthetic pathway in a genetically modified host cell. The present invention also provides genetically modified host cells comprising nucleic acids encoding a scaffold polypeptide and nucleic acids comprising nucleotide sequences encoding two or more enzymes in a biosynthetic pathway.
12/18/14
20140370508
 A method of preparing biological material patent thumbnailnew patent A method of preparing biological material
This invention pertains to a method of preparing biological material from a biological sample selected from the group consisting of blood and sputum samples. The method includes the step of altering at least one constitutive characteristic of the biological sample in the presence of a capturing scaffold by adding a lysis buffer containing a solubilising agent and a detergent to the biological sample, for simultaneously inhibiting coagulation of the biological sample; lysing the biological sample to release the biological material from the biological sample, thus making the biological material available; and capturing at least one fraction of the biological material on the capturing scaffold..
12/18/14
20140370116
 Method and system for treatment of biological tissue patent thumbnailnew patent Method and system for treatment of biological tissue
A composition for reconstruction, replacement or repair of damaged or diseased biological tissue comprising an extracellular matrix (ecm) composition that includes an ecm scaffold component and a bioactive agent component. In a preferred embodiment, the ecm scaffold component comprises mesothelial tissue and the bioactive agent comprises a statin..
12/18/14
20140370094
 Silk-based scaffold platform for engineering tissue constructs patent thumbnailnew patent Silk-based scaffold platform for engineering tissue constructs
The inventions provided herein relate to silk-based scaffolds and methods of producing the same, which can be used for a range of tissue engineering applications. The fabrication methods described herein provide a versatile platform to incorporate hollow conduits (e.g., for nutrient/oxygen delivery) through three-dimensional silk-based scaffolds that have tunable bulk properties (e.g., but not limited to, porosity, mechanical, degradation rate) and allow endothelialization and/or cell compartmentalization, for engineering a variety of complex tissue equivalents..
12/18/14
20140369985
 Removal of tumor cells from intraoperative autologous blood salvage patent thumbnailnew patent Removal of tumor cells from intraoperative autologous blood salvage
The invention relates to a method performed ex vivo for removal of tumor cells from intraoperatively collected blood salvage, to antibodies and scaffold proteins which mimic antibodies for use in said ex vivo method, to the use of said ex vivo method for removal of tumor cells from intraoperatively collected blood salvage followed by reintroducing the so obtained purified blood salvage or of concentrates of erythrocytes purified by said method to a patient from whom said intra-operatively collected blood was obtained, as well as to blood salvage or a concentrate of erythrocytes, both obtainable by said method for reinfusion to said patient.. .
12/18/14
20140369975
 Biomaterials comprising hyaluronic acid binding peptides and bifunctional biopolymer molecules for hyaluronic acid retention and tissue engineering applications patent thumbnailnew patent Biomaterials comprising hyaluronic acid binding peptides and bifunctional biopolymer molecules for hyaluronic acid retention and tissue engineering applications
The present invention provides novel biomaterial compositions and methods having a technology to improve retention of hyaluronic acid (ha). The biomaterial compositions utilize small ha binding peptides that is tethered to synthetic biocompatible polymers.
12/18/14
20140367196
 Scaffold end cover system and method patent thumbnailnew patent Scaffold end cover system and method
A system and method for covering a scaffold end with a scaffold cover. The system includes a cap or scaffold cover having a closed end for providing a force-absorbing surface, and an open end for receiving a scaffold end.
12/11/14
20140364948
Bi-phasic 3-dimenisonal nanofiber scaffolds, two parallel beam collector device and methods of use
A biphasic scaffold and devices and methods for making the scaffold are disclosed. An example scaffold may include (a) a first plurality of randomly-oriented nanofibers defining a first tab region, (b) a second plurality of randomly-oriented nanofibers defining a second tab region, and (c) a plurality of aligned nanofibers coupled to and extending between the first tab region and the second tab region, where the plurality of aligned nanofibers are suspended between the first tab region and the second tab region..
12/11/14
20140364935
Coupled scaffold segments
A scaffold is formed by several segments joined or connected to each other by only at least one coupling. The coupling decouples the segments in the axial direction over a finite distance of axial displacement.
12/11/14
20140363566
Catalytic layer formation
A catalytic layer may be formed by infiltrating a mobile phase including metal salts into a metal scaffold to form a percolated scaffold, drying the percolated scaffold to form a green-group scaffold, and calcining the green-group scaffold such that perovskites form from the metal salts and chemically bind to the metal scaffold.. .
12/11/14
20140363473
Method for preparing spheroids of human primary hepatocytes
The present invention relates to a method for preparing spheroids of human primary hepatocytes. The method comprises culturing of isolated human primary hepatocytes on a polysaccharide scaffold under conditions that allow the formation of hepatocyte spheroids, and subsequently dissolving the polysaccharide scaffold to release the hepatocyte spheroids.
12/11/14
20140360814
Equipment and method for demolishing a building
An equipment (1) for demolishing a building (2), wherein said building (2) comprises a building base (3) placed in proximity of a ground (4), or placed on the ground (4), and an opposite building top (5) or temporary building top (5) arranged away from said building base (3), as well as building floors (6), comprises: —a platform (7) adapted to be positioned against the top of the building (5) avoiding ground support devices which from the platform (7) reach the base of the building (3) or the ground (4) surrounding the building; said platform (7) comprising at least one working scaffold (8) adapted to be arranged along the periphery (9) of said building (2) and to face at least one floor (6) of said building (2); —said at least one working scaffold (8) being supported, hanged, on said platform (7) so that it descends along the side wall (10) of the building (2) to border the works for demolishing the building (2).. .
12/11/14
20140360810
Apparatus and kit for supporting inclined structures
The present invention relates to an apparatus and kit for use in supporting inclined structures. Specifically, the present invention relates to an apparatus and kit useful for extending platforms on a roof in which scaffolding can be built upon.
12/11/14
20140360773
Electrically insulated screen and method of erecting an electrically insulated screen
A method of erecting an electrically insulated screen for a metal scaffold in a defined area with live electrical cables, the method comprising the steps of: erecting a first portion of the screen to a first screen height along a first screen length in the defined area; affixing the first portion of the screen in place using a stabilising mechanism; and erecting a first portion of the scaffold to a first scaffold height and a first scaffold length, wherein: the first scaffold height does not exceed the first screen height, the first scaffold length does not exceed the first screen length, and the first portion of the scaffold is erected on a side of the first portion of the screen that is opposite to a side where the live electrical cables are located.. .
12/04/14
20140357857
Porous structures of microbial-derived cellulose for in vivo implantation
This invention relates to polysaccharide materials and more particularly to microbial-derived cellulose having the porosity and containing pores of the desired size making it suitable for cellular infiltration during implantation and other desirable properties for medical and surgical applications. The invention also relates to the use of porous microbial-derived cellulose as tissue engineering matrices, human tissue substitutes, and reinforcing scaffolds for regenerating injured tissues and augmenting surgical procedures.
12/04/14
20140356407
Biodegradable supporting device
A biodegradable in vivo supporting device is disclosed. The in vivo supporting device comprises a biodegradable metal scaffold and a biodegradable polymer coating covering at least a portion of the biodegradable metal scaffold, wherein the biodegradable polymer coating has a degradation rate that is faster than the degradation rate of the biodegradable metal scaffold..
12/04/14
20140356381
Methods of purifying heterodimeric proteins using immunoglobulin class switching
The present invention describes novel immunoglobulin compositions that co-engage at least two antigens, e.g. A first and second antigen, or, as outlined herein, three or four antigens can be bound, in some of the scaffold formats described herein.
12/04/14
20140353877
Control of degradation profile of bioabsorbable poly(l-lactide) scaffold
Methods of controlling the degradation profile of a biodegradable stent scaffolding are disclosed. Disclosed methods include controlling features of the degradation profile including the time to loss of radial strength and the degradation time of the stent..
11/27/14
20140350692
Biomineralization promoting materials and methods of forming same
Bone tissue biomimetic materials, biomimetic constructs that can be formed with the materials, and methods for forming the materials and constructs are described. The bone tissue biomimetic materials include electrospun nanofibers formed of polymers that are conjugated with peptides that include acidic amino acid residues.
11/27/14
20140350677
Decellularized composite tissue bioscaffolds for musculoskeletal tissue interface reconstruction and methods of production
One aspect of the present invention is a method of producing a decellularized composite tissue bioscaffold for musculoskeletal tissue interface reconstruction by physicochemically treating a musculoskeletal tissue interface isolated from allogeneic sources. In certain embodiments, such musculoskeletal tissue interfaces can also be isolated from xenogeneic sources.
11/27/14
20140350675
Connective tissue repair pad
The invention relates to an implantable prosthetic device for the repair of connective tissue in an animal or a human. In one embodiment, an implantable prosthetic device (100) for the repair of connective tissue (500) in an animal or human is disclosed which comprises a biocompatible pad (101) having an open structure to provide a scaffold for the in-growth of tissue into the pad; and a reinforcement region (206) attached to or formed integrally with the pad.
11/27/14
20140350237
Photo-crosslinked gellan gum-based hydrogels: methods and uses thereof
The matrix can be used either as an acellular or cellular system, dispensed manually or automatically by injection and crosslinked directly at the site of application, and can be processed using manual or automated systems in different types of scaffolds, such as hydrogels, fibres, 3d structures and micro- or nanoparticles.. .
11/27/14
20140349929
Multivalent fibronectin based scaffold domain proteins
The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications.
11/27/14
20140348940
Amniotic membrane hydrogel and methods of making
The present invention provides compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane of the placenta.
11/27/14
20140348839
Modified polypeptides for bispecific antibody scaffolds
The technology relates in part to engineered antibodies. In particular, multispecific engineered antibodies.
11/27/14
20140348800
Modified two-component gelation systems, methods of use and methods of manufacture
A bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.
11/27/14
20140348772
Production of hydrogels by means of diels-alder reaction
The present invention is directed to hydrogels and their preparation by cross-linking macromonomers by means of diels-alder reaction. The hydrogels described in the invention, which can gel in situ, are suitable, inter alia, as biomaterial for medical applications, as scaffolding material for living cells and as carrier system for the controlled release of drugs..
11/27/14
20140345975
Scaffolding assembly
A scaffolding assembly configured for use with an assembly table is provided. In one embodiment, the scaffolding assembly can include an inner scaffolding and an outer scaffolding, wherein the inner scaffolding and the outer scaffolding each include: a plurality of main posts having a lower end and an upper end; an extendible arm connected to each of the main posts, wherein the extendible arm is configured to extend substantially perpendicular from the main post; and a tertiary scaffolding support connected to the extendible arm and the main post, the tertiary support configured to transfer at least some of the force from the extendible arm to the main post, wherein the scaffolding assembly is configured to attach to the assembly table, such that the scaffolding assembly receives support from the assembly table..
11/20/14
20140343690
Tissue scaffold
A tissue scaffold includes a first film having a plurality of cell openings and a second film adjacent the first film and having a plurality of cell openings larger than the cell openings of the first film. The cell openings of the first film interconnect with the cell openings of the second film to define pathways extending through the first and second films..
11/20/14
20140343667
Bioabsorbable biomedical implants
A bioabsorbable biomedical implant is disclosed. The implant includes a tubular scaffold comprising a plurality of interconnected polymer struts.
11/20/14
20140343130
Micro-rna scaffolds, non-naturally occurring micro-rnas, and methods for optimizing non-naturally occurring micro-rnas
The present disclosure provides non-naturally occurring mir-196a-2 mirnas and non-naturally occurring mir-204 mirnas. The non-naturally occurring mirnas of the disclosure have mature strand sequences distinct from their endogenous counterparts.
11/20/14
20140342984
Compositions for regenerating defective or absent myocardium
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition can also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function..
11/20/14
20140342445
Organ chips and uses thereof
Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.. .
11/20/14
20140342015
Amniotic membrane powder and methods of making
The present invention provides compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane of the placenta.
11/20/14
20140342007
Methods of manufacturing bioactive gels from extracellular matrix material
The present invention is directed to methods of manufacturing bioactive gels from ecm material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ecm material can be created by digesting particularized ecm material in an alkaline environment and neutralizing to provide bioactive gels..
11/20/14
20140342000
Porous scaffold with carbon-based nanoparticles
A biocompatible porous scaffolds, especially bone regeneration scaffolds, comprising carbon-based nanoparticles, especially diamond nanoparticles, methods for the production of such biocompatible porous scaffolds, the use of such biocompatible porous scaffolds and methods for treating bone defects by inserting such biocompatible porous scaffolds comprising carbon-based nanoparticles into the bone defect.. .
11/20/14
20140341975
Pathogen and substance traps
A composition-of-matter is provided as well as pharmaceutical compositions and methods of using same. The composition of matter includes least one active moiety surrounded by a scaffold configured for enabling selective influx of an agent capable of interacting with the at least one active moiety..
11/20/14
20140341965
Compositions and methods comprising biodegradable scaffolds and retinal pigment epithelial cells
The invention relates to compositions comprising a monolayer of functional retinal pigment epithelial (rpe) cells attached to a transplantable, biodegradable scaffold. The invention also relates to methods of using these compositions..
11/20/14
20140341871
Regenerative tissue matrix
A process for the preparation of a tissue matrix suitable for regenerative repair of tissues, including contacting an isolated connective tissue with an amount of detergent and an amount of disinfectant to significantly reduce at least one of lipids, phospholipids, nucleic acids, major histocompatibility (mhc) antigens, contaminating microorganisms, and endotoxins. The process further provides for less significant reduction in proteoglycan content while retaining the overall structure of the tissue matrix produced.
11/20/14
20140341870
Biocomposite for regeneration of injured tissue and organs, a kit for making the biocomposite, a method of making the biocomposite and a method of treating injuries
Provided is a biocomposite including cells, a genetic construction, and a scaffold and a method for repairing tissue and organs in mammalians with the biocomposite. The interaction of the components of the biocomposite provides a complex effect on reparative regeneration processes.
11/20/14
20140341865
Dressing material with cell components for wound healing
There is provided a dressing for treating a wound. The dressing for healing a wound can be useful in maintaining a moisture environment at a wound site using a biocompatible polymer scaffold, and effectively promoting healing of a wound by various growth factors secreted by skin cells or stem cells attached to the biocompatible polymer scaffold as well..
11/20/14
20140341804
Homomultivalent and heteromultivalent inhibitors of prostate specific membrane antigen (pmsa) and uses thereof
The present invention provides bivalent and multivalent ligands with a view to improving the affinity and pharmacokinetic properties of a urea class of psma inhibitors. The compounds and their synthesis can be generalized to multivalent compounds of other target antigens.
11/20/14
20140339170
Stackable planar adsorptive devices
Adsorptive bed devices include a scaffold in housing having a stress absorbing rigid structure and open cells filled with adsorptive beads. The scaffold restricts movement of the plurality of adsorptive beads, absorbs compressive stress induced by a hydraulic pressure gradient along a direction of liquid flow and transfers a portion of the induced compressive stress to the housing.
11/20/14
20140339019
Scaffold bracket
Various implementations described herein are directed to a scaffold bracket. In one implementation, the scaffold bracket may include a mounting bracket having a first face and a second face opposite of the first face.
11/13/14
20140336755
Tubular scaffold for fabrication of heart valves
A tubular braided mesh scaffold for fabrication of heart valves is described. The tubular braided scaffold can be formed of a shape memory metal, such as nitinol, and pinched or pressed to form a leaflet shape.
11/13/14
20140336750
Bioresorbable scaffold for neurologic drug delivery
Bioresorbable scaffolds and methods of treatment with such scaffolds for neurologic disorders including parkinson's disease, huntington's disease, alzheimer's disease, and brain neoplasms are disclosed. The bioresorbable scaffold includes a bioresorbable body and an active agent or drug associated with the body for treating or ameliorating the neurological disorder.
11/13/14
20140336748
Bioabsorbable polymeric medical device
In embodiments there is described a cardiovascular tube-shaped lockable and expandable bioabsorbable scaffold having a low immunogenicity manufactured from a crystallizable bioabsorbable polymer composition or blend.. .
11/13/14
20140336710
Device and method for orthopedic fracture fixation
The present invention relates invention relates to devices and methods for the fixation and stabilization of orthopedic fractures and more specifically to stabilization of compression fractures of spinal vertebrae. The systems comprise cannulated orthopedic screws and mechanical expandable implants introducible through the lumen of such screws.
11/13/14
20140336557
Biopolymer multi-layer multi-functional medical dressing and method of making same
The technology described herein applies to medical dressings designed to heal wounds in the area of advanced wound care, inclusive of negative pressure wound therapy (npwt), and describes novel wound healing absorbent scaffolds and dressing based on natural and naturally-derived material and fibers, preferentially poly (lactic) acid fibers and alginate materials.. .
11/13/14
20140336242
Micro-rna scaffolds and non-naturally occurring micro-rnas
The present disclosure provides a non-naturally occurring mirna having a stem-loop structure comprising a scaffold derived from a first endogenous mirna (e.g., mir-196a-2 or mir-204), a mature strand derived from a second endogenous mirna, and a star strand sequence that is at least partially complementary to the mature strand sequence. The present disclosure also provides a non-naturally occurring mirna having a stem-loop structure comprising a scaffold derived from an endogenous mirna (e.g., mir-196a-2 or mir-204), a mature strand designed to be at least partially complementary to a target rna, and a star strand sequence that is at least partially complementary to the mature strand sequence.
11/13/14
20140335144
Tissue scaffolds derived from forestomach extracellular matrix
The present invention pertains to the development of extracellular matrix (ecm) scaffolds derived from the forestomach of a ruminant. Such scaffolds are useful in many clinical and therapeutic applications, including wound repair, tissue regeneration, and breast reconstruction.
11/13/14
20140335141
Layered manufacturing utilizing foam as a support and multifunctional material for the creation of parts and for tissue engineering
One aspect of the invention provides a solid freeform fabrication method of creating a three-dimensional article built at least in part from scaffolding layers. The method includes: providing a scaffolding material; providing a supporting material in a shape of a foamy layer; and contacting the scaffolding material with the foamy layer to form at least one scaffolding layer and thereby creating the three dimensional article.
11/13/14
20140335050
Methods, compositions, and kits for the treatment of cancer
The invention features methods, compositions, and kits for the administration of an hsp90 inhibitor, obaa, flunarizine, aphidicolin, damnacanthal, dantrolene, or an analog thereof, alone, or in combination with, e.g., a taa, an antigen-binding scaffold (e.g., an antibody, a soluble t cell receptor, or a chimeric receptor) specific for a taa, a cell (e.g., a white blood cell that targets a cancer cell), and/or an ifn-β receptor agonist or an ifn-γ receptor agonist, for the treatment of cancer.. .
11/06/14
20140330392
Scaffolds for tissues and uses thereof
The present invention provides tissue scaffolds, methods of generating such scaffolds, and methods of use of such scaffolds to generate aligned and functional tissues for use in methods including regenerative medicine, wound repair, and transplantation.. .
11/06/14
20140330363
Polymer scaffolds having a low crossing profile
A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%.
11/06/14
20140330361
Segmented scaffold designs
Segmented scaffolds composed of disconnected scaffold segments with overlapping end rings are disclosed. Scaffolds with at least one discontinuous link are also disclosed..
11/06/14
20140330360
Segmented scaffold designs
Segmented scaffolds composed of disconnected scaffold segments with overlapping end rings are disclosed. Scaffolds with at least one discontinuous link are also disclosed..
11/06/14
20140330359
Methods and apparatus for stent delivery and deployment
For scaffolds delivered and deployed intravascularly, one or several configurations may be employed for creating a smoother transition from balloon-to-scaffold. For instance, one or more spacers may be positioned in proximity to the scaffold.
11/06/14
20140330310
Patent foramen ovale (pfo) closure device with radial and circumferential support
The present invention provides a device for occluding an anatomical aperture, such as a septal defect or patent foramen ovale (pfo). The occluder includes two sides connected by an intermediate joint.


Popular terms: [SEARCH]

Scaffold topics: Nucleotide, Recombinant, Polynucleotide, Amino Acid, Biodegradable, Encapsulation, Surfactant, Enhancement, Monoclonal Antibody, Polypeptide, Immunogenic, Amino Acid Sequence, Monoclonal, Interleukin 2, Immune Disease

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