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Scaffold patents



      

This page is updated frequently with new Scaffold-related patent applications.




Date/App# patent app List of recent Scaffold-related patents
06/16/16
20160169877 
 Patterning silica islands onto thermoplastic shrink film patent thumbnailPatterning silica islands onto thermoplastic shrink film
The disclosure relates to methods and devices for measuring samples, such as biological samples, especially those at low abundance, with high sensitivity and at low cost. A sample is disposed on a shrinkable scaffold and the shrinkable scaffold is shrunk, reducing the area where the sample is distributed, so as to effectively concentrate the sample on the surface of the scaffold.
The Regents Of The University Of California


06/16/16
20160168754 
 Electrospinning  producing multi-dimensional structures and core-sheath yarns patent thumbnailElectrospinning producing multi-dimensional structures and core-sheath yarns
Electrospinning apparatus and method for producing multi-dimensional structures such as one-dimensional continuous yarns, two-dimensional mats and three-dimensional cotton-like fluffy scaffolds is disclosed. Further, electrospinning apparatus and method with single collector geometry for producing multi-dimensional structures and core-sheath yarns are disclosed..
Amrita Vishwa Vidyapeetham


06/16/16
20160168542 
 Tissue engineered models of cancers patent thumbnailTissue engineered models of cancers
A 3d decellularized bone scaffold seeded with cancer cells, such as prostate cancer cells or ewing's sarcoma is provided. It provides platform technology for controllable, quantitative, long-term studies of tissue-engineered tumors, including prostate cancer and ewing's sarcoma.
The Trustees Of Columbia Unicersity In The City Of New York


06/16/16
20160168525 
 Cell culturing method, particulate culture carrier, and particle-encompassing cell aggregate patent thumbnailCell culturing method, particulate culture carrier, and particle-encompassing cell aggregate
Provided is a culturing method capable of causing a three-dimensional aggregate in which cell function is similar to in vivo function to adhere to a culturing vessel while improving permeability of nutrients, oxygen, drugs and reagents from the culture medium and maintaining cell function. By sowing isolated cells in a culturing vessel, and after the cells have settled on the culturing surface, administering microscaffold particles that are cell-adhesive and substance-permeable onto the cells, it is possible to cause the cells to adhere to the culturing vessel while forming cell aggregates that encompass the particles.
Hitachi High-technologies Corporation


06/16/16
20160167132 
 Additive manufacturing of porous scaffold structures patent thumbnailAdditive manufacturing of porous scaffold structures
Techniques for additive deposition are disclosed herein. In one embodiment, a method includes depositing a first portion of a precursor material onto a deposition platform, the precursor material including a suspension of nano-particles and forming a first solid structure of the nano-particles on the deposition platform from the deposited first layer of the precursor material.
Washington State University


06/16/16
20160166733 
 Engineered neural tissue patent thumbnailEngineered neural tissue
A method for producing an engineered tissue scaffold for neural repair is described. The method includes tethering a hydrogel matrix seeded with tension-generating cells to a frame, and allowing the tension-generating cells to generate tension within the matrix, such that the cells self-align.
The Open University


06/16/16
20160166374 
 Tubular vascular graft and the preparation thereof patent thumbnailTubular vascular graft and the preparation thereof
The present invention provides a reparation method of a tubular vascular graft, (a) immersing a tubular scaffold in a first light sensitivity gelatin solution, and irradiate the tubular scaffold by a first time period, to let surface of the tubular scaffold form a base layer; (b) immersing the tubular scaffold of the step (a) in a chitin gelatin solution, when the surface of the base layer form a film, then immersing the tubular scaffold into a sodium hydroxide solution to generate a middle layer of the surface of the base layer; (c) immersing the tubular scaffold of the step (b) in a second light sensitivity gelatin solution, wherein the second light sensitivity gelatin solution comprises a cell, the tubular scaffold is irradiated by a second time period to form a surface layer of the middle layer; (d) until the cell forms a tubular structure of the surface layer by the cell in the tubular scaffold of the step (c), heating the tubular scaffold by a temperature to solve the base layer into a solution, pulling out the tubular scaffold to get an artificial blood vessels.. .
National Tsing Hua University


06/09/16
20160161453 
 Stackable planar adsorptive devices patent thumbnailStackable planar adsorptive devices
Adsorptive bed devices include a scaffold in housing having a stress absorbing rigid structure and open cells filled with adsorptive beads. The scaffold restricts movement of the plurality of adsorptive beads, absorbs stress induced by a hydraulic pressure gradient along a direction of liquid flow and transfers a portion of the induced compressive stress to the housing.
Spf Technologies Llc


06/09/16
20160161415 
 Metal-antibody tagging and plasma-based detection patent thumbnailMetal-antibody tagging and plasma-based detection
A target within a sample can be characterized using an energy source configured to transform a metal in the sample into a plasma and an optical spectroscopic detector configured to detect electromagnetic radiation emitted by the plasma to provide an optical-spectrum signal. A processor can determine presence of the metal in the sample using the optical-spectrum signal.
Purdue Research Foundation


06/09/16
20160160513 
 Adjustable scaffold assembly patent thumbnailAdjustable scaffold assembly
An adjustable scaffold assembly includes a pair of vertical supports. A pair of hand rails is provided.

06/09/16
20160160206 

Aldehyde-tagged protein-based drug carriers and methods of use


The disclosure provides aldehyde-tagged protein carriers that can be covalently and site-specifically bound to drug to provide a drug-containing scaffold. The invention also encompasses methods of production of such drug-containing scaffolds and intermediates, as well as methods of use..
Redwood Bioscience, Inc.


06/09/16
20160159954 

Polydendrons


A method of preparing a ph-responsive non-gelled branched vinyl polymer scaffold carrying dendrons, comprising the living or controlled polymerization of a mono functional vinyl monomer and a difunctional vinyl monomer, using a dendron initiator.. .
The Univeristy Of Liverpool


06/09/16
20160159940 

Polydendrons


A method of preparing a non-gelled branched vinyl polymer scaffold carrying dendrons, comprising the living or controlled polymerization of a monofunctional vinyl monomer and a difunctional vinyl monomer, using a dendron initiator and at least one further initiator.. .
The Univeristy Of Liverpool


06/09/16
20160159900 

Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for regulating the fluid balance in a patient having a chronic or acute disease


The present invention also provides a method for regulating the fluid balance in a patient having a chronic or acute disease or acute condition. Subject matter of the present invention is an anti-adrenomedullin adm antibody or anti-adm non-ig scaffold or an anti-adrenomedullin antibody fragment for use in therapy of a chronic or acute disease or acute condition of a patient for the regulation of fluid balance..

06/09/16
20160159883 

Fibronectin based scaffold domain proteins that bind pcsk9


The present invention relates to fibronectin based scaffold domain proteins that bind pcsk9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases.
Bristol-myers Squibb Company


06/09/16
20160159869 

Bmp-2-binding peptide amphiphile nanofibers


Provided herein are peptide amphiphiles with binding affinity for the bone promoting growth factor bmp-2, and methods of use thereof. In particular nanofibers and gel scaffolds of bmp-2-binding peptide amphiphiles are provided..
Northwestern University


06/09/16
20160159006 

Pneumatic manufacturing system for complex tissues and organs, having multiple degrees of freedom and multiple nozzles


Disclosed is a pneumatic manufacturing system for complex tissues and organs, having multiple degrees of freedom and multiple nozzles, belonging to the organs manufacturing field. The system comprises an x-direction movement mechanism, a y-direction movement mechanism, a q-direction rotation mechanism, a lifting platform, a rotation-forming platform, a shell, a high-pressure gas source, a multiple-nozzle forming unit, a spraying solution pressure tank, a temperature control device, a sterilizing device and a control unit.
Tsinghua University


06/09/16
20160158422 

Biodegradable supporting device


A biodegradable in vivo supporting device is disclosed. The in vivo supporting device comprises a biodegradable metal scaffold and a biodegradable polymer coating covering at least a portion of the biodegradable metal scaffold, wherein the biodegradable polymer coating has a degradation rate that is faster than the degradation rate of the biodegradable metal scaffold..
Q3 Medical Devices Limited


06/09/16
20160158416 

Scaffold for hard tissue regeneration containing active ingredient for treating osteoporosis and preparing method thereof


A scaffold for hard tissue regeneration comprising an active ingredient for treating osteoporosis and a preparation method thereof. The scaffold for hard tissue regeneration is prepared by the steps of mixing a polyphenol-based natural substance containing quercetein or genistein involved in the activation of osteoblasts and osteoclasts and the biofunctional analogue thereof with a ceramic scaffold material and molding the mixture at room temperature into a three-dimensional scaffold.
Korea Institute Of Machinery And Materials


06/09/16
20160158411 

Protein biomaterials and biocoacervates and methods of making and using thereof


The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention relates to protein biocoacervates and biomaterials that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, coated medical devices (e.g.
Gel-del Technologies, Inc.


06/09/16
20160158046 

Flow regulation valve for controlling inflation rate of a balloon deploying a scaffold


An apparatus and method for controlling inflation pressure, pressurization rate, and volumetric flow rate of a balloon during deployment of a stent or scaffold is disclosed.. .
Abbott Cardiovascular Systems Inc.


06/09/16
20160157992 

Tissue interface augmentation device for ligament/tendon reconstruction


The present invention relates to a device for the interfacial augmentation of tissue grafts for the purpose of tendon and ligament reconstruction. The inventive device works both as a delivery vessel for osteoconductive and osteoinductive factors and as a scaffold to stimulate and support bone ingrowth and comprises a tubular composite silk sheath, said tubular composite silk sheath comprising: a backbone consisting of a tubular silk mesh, and a carrier material consisting of a porous silk sponge, wherein said tubular silk mesh consists of degummed silk fibroin fibers, wherein said porous silk sponge comprises silk fibroin fibers and hydroxyapatite particles and said tubular silk mesh and said porous silk sponge form a composite material.
Agency For Science, Technology And Research


06/02/16
20160153205 

Scaffolding pipe of a structural scaffolding system and scaffolding element


A scaffolding pipe of a structural scaffolding system extends from a first axial pipe end to an opposing second axial pipe end. A receiving portion is provided on the first axial pipe end and an insertion portion is provided on the second axial pipe end.
Peri Gmbh


06/02/16
20160152766 

Polymer scaffold degradation control via chemical control


A variety of polymers and copolymers suitable for use as biologically compatible constructs and, as a non-limiting specific example, in the formation of degradable tissue scaffolds as well methods for synthesizing these polymers and copolymers are described. The polymers and copolymers have degradation rates that are substantially faster than those of previously described polymers suitable for the same uses.
Stc.unm


06/02/16
20160152686 

Fibronectin based scaffold domains linked to serum albumin or moiety binding thereto


Provided herein are fusion proteins comprising a first moiety comprising a fibronectin based scaffold and a second moiety comprising serum albumin or a biologically active fragment thereof or a serum albumin binding domain or a biologically active fragment thereof.. .
Bristol-myers Squibb Company


06/02/16
20160151762 

Formation of high surface area metal-organic frameworks


A metal-organic framework (mof) structure comprising at least one metal ion and at least one multidentate organic ligand which is coordinately bonded to said metal ion, and a scaffold.. .
Numat Technologies, Inc.


06/02/16
20160151546 

Biodegradable supporting device


A biodegradable in vivo supporting device is disclosed. The in vivo supporting device comprises a biodegradable metal scaffold and a biodegradable polymer coating covering at least a portion of the biodegradable metal scaffold, wherein the biodegradable polymer coating has a degradation rate that is faster than the degradation rate of the biodegradable metal scaffold..
Q3 Medical Devices Limited


06/02/16
20160151541 

Methods and devices for cellular transplantation


Devices and methods for transplanting cells in a host body are described. The cell comprises a porous scaffold that allows ingrowth of vascular and connective tissues, a plug or plug system configured for placement within the porous scaffold, and a seal configured to enclose a proximal opening in the porous scaffold.
Sernova Corporation


06/02/16
20160151540 

Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells


Provided herein are constructs of micro-aggregate multicellular, minimally polarized grafts containing leucine-rich repeat-containing g-protein coupled receptor (lgr) expressing cells for wound therapy applications, tissue engineering, cell therapy applications, regenerative medicine applications, medical/therapeutic applications, tissue healing applications, immune therapy applications, and tissue transplant therapy applications which preferably are associated with a delivery vector/substrate/support/scaffold for direct application.. .

06/02/16
20160151153 

Segmented transcatheter valve prosthesis having an unsupported valve segment


Embodiments hereof relate to a transcatheter valve prosthesis including a tubular fabric body, a first or inflow tubular scaffold attached to a first end portion of the tubular fabric body, and a second or outflow tubular scaffold attached to a second end portion of the tubular fabric body. A prosthetic valve component is disposed within and secured to an intermediate portion of the tubular fabric body that longitudinally extends between the first and second end portions of the tubular fabric body.
Medtronic, Inc.


05/26/16
20160145968 

Smart cellular structures for composite packer and mill-free bridgeplug seals having enhanced pressure rating


A smart device includes a scaffold that responds to an applied stimulation and an encapsulating structure that encapsulates the scaffold. The scaffold is formed from at least one smart material that responds to the applied stimulation.
Schlumberger Technology Corporation


05/26/16
20160145574 

Kit and promoting mesenchymal stem cell differentiation


The present invention is related to a kit comprising: (a) a mesenchymal stem cell; (b) a gelatin-hyaluronan-chondroitin tri-copolymer scaffold; (c) a kartogenin; and (d) a bioreactor. The present invention is also related to a method for promoting differentiation of a mesenchymal stem cell into cartilage tissue, comprising: (a) culturing the mesenchymal stem cell on a gelatin- hyaluronan-chondroitin tri-copolymer scaffold in the presence of a kartogenin; and (b) culturing the mesenchymal stem cell and the gelatin-hyaluronan-chondroitin tri-copolymer scaffold in a bioreactor..
National Taiwan University


05/26/16
20160145193 

Dual site catalyst for mild, selective nitrile reduction


A ruthenium bis(pyrazolyl)borate scaffold that enables cooperative reduction reactivity in which boron and ruthenium centers work in concert to effect selective nitrile reduction is provided. The pre-catalyst compound [κ3-(1-pz)2hb(n═chch3)]ru(cymene)− tfo− (pz=pyrazolyl) was synthesized using readily-available materials through a straightforward route, thus making it an appealing catalyst for a number of reactions..
University Of Southern California


05/26/16
20160144390 

Adjustable support for tubular medical device processing


An apparatus and method for supporting a tubular medical device, such as a stent or scaffold, includes a rod disposed between two collets. The rod can be shaped to form a range of different size or length helical supports to support a wide range of tubular medical devices.
Abbott Cardiovascular Systems Inc.


05/26/16
20160144389 

Adjustable support for tubular medical device processing


An apparatus and method for supporting a tubular medical device, such as a stent or scaffold, includes a rod disposed between two collets. The rod can be shaped to form a range of different size or length helical supports to support a wide range of tubular medical devices.
Abbott Cardiovascular Systems Inc.


05/26/16
20160144071 

Biomimetic collagen-hydroxyapatite composite material


The invention relates to: a biomimetic collagen-hydroxyapatite composite material comprising an at least partially fibrous collagen scaffold including mature native collagen fibers possessing triple helicity as shown by circular dichroism spectroscopy, wherein those mature native collagen fibers are at least partially covered with epitactically grown crystals of nanocrystalline hydroxyapatite, whereby the epitactically grown nanocrystals have the same morphology as human bone mineral and the same size as human bone mineral, i.e. A length of 30 to 50 nm and a width of 14 to 25 nm, a process of preparing the above biomimetic collagen-hydroxyapatite composite material comprising the steps of a) immersing an at least partially fibrous collagen scaffold including the above mature native collagen fibers in a saturated aqueous solution of saturated ca2+/hx-po4(3-x) to start the formation process of the composite implant material whereby epitactically grown nanocrystals will be formed on the mature native collagen fibers, the epitactically grown nanocrystals having the same morphology and same size as human bone mineral, b) stopping the formation process of the composite implant material by separating solid material from the aqueous solution, rinsing with water and drying, and c) optionally sterilizing the separated material coming from step b), as well as the use of the above biomimetic collagen-hydroxyapatite composite material as an implant or prosthesis for bone formation, bone regeneration, bone repair and/or bone replacement at a defect site in a human subject or in an animal, or as an implant for combined bone and cartilage regeneration..
Geistlich Pharma Ag


05/26/16
20160144069 

Suturable hybrid superporous hydrogel keratoprosthesis for cornea


The present invention features a superporous hydrogel scaffold for corneal regeneration or replacement and a method for producing the same. The superporous hydrogel is composed of a poly(2-hydroxyethyl methacrylate) (phema) and poly(methyl methacrylate) (pmma) copolymer mixed with collagen.
The Board Of Trustees Of The University Of Illinois


05/26/16
20160144049 

Carriers for improved drug delivery


The invention provides carriers that enhance the absorption, half-life or bioavailability of therapeutic compounds. The carriers comprise targeting groups that bind the vitamin d binding protein (dbp), conjugation groups for coupling the targeting groups to the therapeutic compounds, and optionally scaffolding moieties..
Extend Biosciences, Inc.


05/26/16
20160143745 

Intervertebral disc implant


The disclosure relates to an intervertebral disc implant comprising a first construct comprising a continuous layer of nucleus pulposus (np) tissue directly or indirectly on and integrated with a substrate, and a second construct surrounding the first construct comprising one or more continuous layers of annulus fibrosus (af) tissue on and adherent to a scaffold, wherein the af tissue, which is composed of single or multiple adherent layers, is integrated with the np tissue. The disclosure also relates to methods of preparing the multi-tissue intervertebral disc and using the intervertebral disc as an implant..
Mount Sinai Hospital


05/26/16
20160143741 

Joint bioscaffolds


Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of using scaffolds for treating degenerative tissue disorders.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education


05/19/16
20160141112 

Solar cell and process for producing the same


The present invention relates to photoanodes, solar cells and methods and processes for producing the same. In some embodiments, the solar cells of the invention can do without a sintered nanoporous scaffold layer, making it possible to produce the solar cells in low-temperature procedures.
Ecole Polytechnique Federale De Lausanne (epfl)


05/19/16
20160140326 

Simulated carbon and proton nmr chemical shifts based binary fingerprints for virtual screening


The invention discloses a method to generate and analyze nmr chemical shift based binary fingerprints for virtual high throughput screening in drug discovery. Further, the invention provides a method to analyze nmr chemical shifts based binary fingerprints that has implications for encoding several properties of a molecule besides the basic framework or scaffold and determine its propensity towards a particular bioactivity class..
Council Of Scientific & Industrial Research


05/19/16
20160137838 

Methods of producing polyurethane three-dimensional objects from materials having multiple mechanisms of hardening


A method of forming a three-dimensional object of polyurethane, polyurea, or copolymer thereof is carried out by: (a) providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; (b) filling the build region with a polymerizable liquid, the polymerizable liquid including at least one of: (i) a blocked or reactive blocked prepolymer, (ii) a blocked or reactive blocked diisocyanate, or (iii) a blocked or reactive blocked diisocyanate chain extender; (c) irradiating the build region with light through the optically transparent member to form a solid blocked polymer scaffold and advancing the carrier away from the build surface to form a three-dimensional intermediate having the same shape as, or a shape to be imparted to, the three-dimensional object, with the intermediate containing the chain extender; and then (d) heating or microwave irradiating the three-dimensional intermediate sufficiently to form from the three-dimensional intermediate the three-dimensional object of polyurethane, polyurea, or copolymer thereof.. .
Carbon3d, Inc.


05/19/16
20160137694 

Peptide and complex of same, scaffold for tissue repair and surface treatment same, and surface treatment solution or set of treatment solutions


Provided are a peptide that enables surface treatment of a scaffold for tissue repair that makes it possible to accelerate the repair of living tissue without using a material that negatively affects the repair of living tissue, a complex containing this peptide, a scaffold for tissue repair surface treated using this peptide or this complex, a surface treatment method for a scaffold for tissue repair using this peptide or this complex, and a treatment solution or set of treatment solutions to be used in this surface treatment method. Surface treatment of a scaffold for tissue repair is conducted by combining glycosaminoglycan and a peptide containing adhesive sites and basic sites each comprising predetermined amino acid residues..
Jms Co., Ltd.


05/19/16
20160137562 

Lightweight assemblable appliance and respective production of biogas and liquid fertilizer


A system and method of recycling organic waste into biogas, implementing an anaerobic digestion processes, is disclosed. The system includes structural scaffolding and a pliable collapsible anaerobic digester.
Ecogas Israel Ltd


05/19/16
20160136889 

Methods of producing three-dimensional objects from materials having multiple mechanisms of hardening


A method of forming a three-dimensional object is carried out by: (a) providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; (b) filling the build region with a polymerizable liquid, the polymerizable liquid including a mixture of (i) a light polymerizable liquid first component, and (ii) a second solidifiable component that is different from the first component; (c) irradiating the build region with light through the optically transparent member to form a solid polymer scaffold from the first component and also advancing the carrier away from the build surface to form a three-dimensional intermediate having the same shape as, or a shape to be imparted to, the three-dimensional object, and containing the second solidifiable component carried in the scaffold in unsolidified and/or uncured form; and (d) concurrently with or subsequent to the irradiating step, solidifying and/or curing the second solidifiable component in the three-dimensional intermediate to form the three-dimensional object.. .
Carbon3d, Inc.


05/19/16
20160136334 

Stents modified with material comprising amnion tissue and corresponding processes


A stent scaffold combined with amniotic tissue provides for a biocompatible stent that has improved biocompatibility and hemocompatibility. The amnion tissue can be variously modified or unmodified form of amnion tissue such as non-cryo amnion tissue, solubilized amnion tissue, amnion tissue fabric, chemically modified amnion tissue, amnion tissue treated with radiation, amnion tissue treated with heat, or a combination thereof.
Peytant Solutions, Inc.


05/19/16
20160136330 

Three-dimensional scaffold functionalized with micro-tissues for tissue regeneration


The present invention concerns a biomaterial devoid of a growth factor, comprising: —a three-dimensional scaffold made of a biocompatible polymer; and—living cells, wherein said living cells are in form of microtissues and the nanofibrous three-dimensional scaffold is a nanofibrous scaffold. It further concerns a method for manufacturing such a biomaterial.
Universite De Strasbourg


05/19/16
20160136327 

3d tissue-engineered bone marrow for personalized therapy and drug development


A tissue-engineered bone marrow for personalized therapy of a patient is described. The tissue-engineered bone marrow includes an autologous fibrin scaffold and a plurality of patient-derived cells isolated from the patient's bone marrow.
Washington University


05/19/16
20160136326 

Compositions and methods for making biodegradable structures


A composition including ppf or a ppf copolymer that can be used to fabricate biodegradable structures. The composition can be used in 3-d patterning (e.g., 3-d printing and sterolighography) methods.
University Of Maryland, College Park


05/19/16
20160136309 

Bifunctional chelating agents based on the 1,4-diazepine scaffold (daza) for non-invasive molecular imaging


Based on 1,4-diazepine with groups r1, r2, r3, r4, x1, x2, x3. The compound is particularly suited for complexation of radio-isotopic metals, such as 66ga(iii), 67ga(iii) and 68ga(iii)..

05/19/16
20160135955 

Shape-memory-actuated materials for accelerated healing of orthopedic injuries


A three component system for repairing critically sized bone defects having a first shape memory polymer (smp) component formed as a scaffold that fills the defects, a second smp component formed as a restricting sleeve that stabilizes and supports osseointegration and osteoconduction, and a third smp component formed as a two-dimensional cell culture substate for engineering periosteal grafts.. .
Syracuse University


05/19/16
20160135836 

Temporary vascular scaffold and scoring device


Devices and methods for treating a target site in a body lumen are provided. A medical device includes a stent-like structure including a plurality of scoring and non-scoring filaments interwoven with one another.
Quadra Endovascular, Inc.


05/19/16
20160135797 

Medical device for wound closure and use


A wound closure device for repairing perforations and tissue wall defects is disclosed herein. The wound closure device has a barbed elongate body and a plug member.
Covidien Lp


05/12/16
20160130824 

Safe scaffold structure with guardrails


A safe scaffold includes door type frames, crossbars, and toe boards. The door type frame has a ledger, located in the lower end, connected to standards that are parallel to each other and are installed with combined pins thereon individually.

05/12/16
20160129153 

Methods of manufacturing bioactive gels from extracellular matrix material


The present invention is directed to methods of manufacturing bioactive gels from ecm material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ecm material can be created by digesting particularized ecm material in an alkaline environment and neutralizing to provide bioactive gels..
Acell, Inc.


05/12/16
20160128834 

Scaffold implant system


The present invention is directed to isolated scaffold implant system comprising a stable combination of an implant fixture and a bone block, wherein said stable combination is suitable in size and form to be implanted within a prepared site in a subject's bone. The scaffold implant system of the present invention is particularly suitable for use in dental implant techniques..

05/12/16
20160128818 

Scaffolds for soft tissue and uses thereof


The present invention provides tissue scaffolds, methods of generating such scaffolds, and methods of use of such scaffolds to generate aligned and functional tissues for use in methods including regenerative medicine, wound repair and transplantation.. .
The Trustees Of Princeton University


05/05/16
20160122560 

Enhanced luminescence from nanopolished surface and plate wells


The present invention relates to a method for fabricating a new silver coating/nanoparticle scaffold that significantly enhances the luminescence of near-field fluorophores via the metal enhanced fluorescence phenomenon. The silver coating/nanoparticle scaffold can be used for numerous applications in metal-enhanced fluorescence..
Univserity Of Maryland, Baltimore County


05/05/16
20160122357 

Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders


The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including mps1 (ttk), erk5 (bmk1, mapk7), polo kinase 1, 2, 3, or 4, ack1, ack2, abl, dcamkl1, abl1, abl mutants, dcamkl2, ark5, brk, mknk2, fgfr4, tnk1, plk1, ulk2, plk4, prkd1, prkd2, prkd3, ros1, rps6ka6, taok1, taok3, tnk2, bcr-abl, gak, csrc, tpr-met, tie2, met, fgfr3, aurora, axl, bmx, btk, c-kit, chk2, flt3, mst2, p70s6k, pdgfr, pkb, pkc, raf, rock-h, rsk1, sgk, trka, trkb and trkc, and the use of such compounds in the treatment of various diseases, disorders or conditions.. .
Dana-farber Cancer Institute, Inc.


04/28/16
20160115697 

Suspended scaffolding structure and connector therefor


A suspended scaffolding connector includes a central spine comprising an anchor connector at a top end thereof, a bottom lug at a bottom end thereof, and a top lug situated between the anchor connector and bottom lug. The connector further includes at least one top truss connector attached to the top lug and at least one bottom truss connector attached to the bottom lug, where the top and bottom truss connectors are configured and spaced for structural connection to top and bottom connectors of a scaffolding truss.

04/28/16
20160115127 

Electro-fluorescent emitter for ultra-violet oled


The present invention demonstrates a newly designed and synthesized carbazole scaffold based electro-fluorescent emitter, 9-butyl-2,7-(2-(4-methoxyphenyl)ethynyl)-9h-carbazole (cz(aphome)2), for ultra-violet oled. This novel emitter has showed a high quantum yield of ˜78%.
National Tsing Hua University


04/28/16
20160115079 

Self standing nanoparticle networks/scaffolds with controllable void dimensions


The present invention discloses a self standing network or scaffold of nanoparticles with controllably variable mesh size between 500 nm and 1 mm having particle volume fraction between 0.5 to 50%. The network comprises nanoparticles, a surfactant capable of forming ordered structured phases and a cross linking agent, wherein the surfactant is washed off leaving the self standing scaffold.
Council Of Scientific & Industrial Research


04/28/16
20160114079 

Composite grafts, systems, and methods


Composite grafts including a biocompatible, synthetic scaffold; and a biological tissue component obtained or derived from a deceased donor tissue, wherein the biological tissue component is embedded in the biocompatible, synthetic scaffold, are provided as systems relating thereto. Methods of manufacture and methods of treatment using such grafts are also provided..
Allosource


04/28/16
20160114078 

Treatment of skeletal voids with implantable substrate hydrated with bone marrow concentrate


The invention is directed to a bone void filler comprising a scaffold or matrix. The scaffold or matrix may include a porous inorganic matrix component.
Spinesmith Partners, L.p.


04/28/16
20160114077 

Elastomeric and degradable polymer scaffolds and high-mineral content polymer composites, and in vivo applications thereof


This invention provides novel synthetic bone grafting materials or tissue engineering scaffolds with desired structural and biological properties (e.g., well-controlled macroporosities, spatially defined biological microenvironment, good handling characteristics, self-anchoring capabilities and shape memory properties) and methods of their applications in vivo.. .
University Of Massachusetts Medical School


04/28/16
20160113786 

Vascular remodeling device


A generally spherical vascular remodeling device is permanently positionable at a junction of afferent and efferent vessels of a bifurcation having an aneurysm. After positioning the device at the junction to substantially conform the device to the shape of the junction, the device acts as a scaffolding to inhibit herniation of objects out of the aneurysm and the device permits perfusion to the efferent vessels.
Covidien Lp


04/28/16
20160113709 

Myocardial ablation by irreversible electroporation


Selective cellular ablation by electroporation, applicable, for example, to bulk tissue in the beating heart. Protocol parameters potentially induce tissue loss without thermal damage.
Tel Hashomer Medical Research Infrastructure And Services Ltd


04/21/16
20160111224 

Photovoltaic device and manufacture using ferovs


The photovoltaic device is formed by coating a substrate with a transparent conducting oxide and then this layer is coated with a dioxide layer. The dioxide layer is then coated in a single step with a precursor solution including metal oxide nanoparticles and perovskites and this precursor can be heated to form a scaffold having a perovskite light absorber and electron transporter.

04/21/16
20160109341 

Device and detecting the tension on a guide rope of a hanging scaffold in a construction shaft


The present invention discloses a device and a method for detecting the tension on a guide rope of a hanging scaffold in a construction shaft. The guide rope is released by a winch, rounds over a hoisting sheave, is connected to the hanging scaffold, and then is tensioned up; the hoisting sheave is disposed at a position above the winch, and the device comprises a slide device, two tension ropes, and a pull rope, wherein, the slide device is fitted around the guide rope, the two tension ropes are fixed to the two sides of the slide device respectively and arranged parallel to the guide rope, the pull rope is fixed to the lower part of the slide device and arranged perpendicular to the guide rope.

04/21/16
20160108628 

Aluminum roof scaffolding plank


A roof scaffolding system comprising an aluminum roof scaffolding plank constructed from high strength aluminum having a unique c-shaped design with molded features that imparts, stability and weight bearing strength to the plank when it is mounted on roof scaffolding brackets. The plank has ridges on its top surface to provide a non-slip surface and a plurality of holes along the sides at the top and the bottom to enable a lock pin to be inserted through them and through a roof bracket hole to secure the plank to the roof bracket.

04/21/16
20160108358 

Method of assembling a 3d tissue culturing scaffold


A continuous device for culturing mammalian cells in a three-dimensional structure for the transplantation or implantation in vivo is described. The culturing device comprises (a) a scaffold formed by a matrix of interconnected growth surfaces spaced at regular intervals and (b) a fluid distribution means at the inlet and the exit of the growth areas.

04/21/16
20160108122 

Therapeutic or prophylactic agent for immunodeficiency virus infection


Disclosed is a novel means that enables complete cure of not only acute and chronic virus infections, but also latent retrovirus infections in which incorporation of the virus into the host chromosome has occurred. In the present invention, by destroying cells containing molecules that act as scaffolds for the virus infection in the patient's body, cells per se that have been already infected with virus are destroyed while inhibiting expansion of the virus infection in the patient's body, so that final complete cure of virus infection can be realized.

04/21/16
20160107390 

Three-dimensional printer having an expandable envelope


A computer program product includes a computer readable storage medium having program instructions embodied therewith and executable by a processor to cause the processor to perform a method. The method includes a three-dimensional printer printing a first layer of an object onto a surface that is not part of the three-dimensional printer, wherein the first layer is printed while a printing platform of the three dimensional printer is in a first position.

04/21/16
20160107378 

Three-dimensional printer having an expandable envelope


One embodiment of the present invention provides a method of three-dimensional printing. The method includes a three-dimensional printer printing a first layer of an object onto a surface that is not part of the three-dimensional printer, wherein the first layer is printed while a printing platform of the three dimensional printer is in a first position.

04/21/16
20160106886 

Metal-coated scaffolds for tissue engineering


Metal nanoparticle-coated scaffolds are provided for use in tissue engineering.. .

04/21/16
20160106885 

Composite scaffold for tissue repair


A synthetic composite material for tissue repair is disclosed which includes a first layer having an organic material and having side walls and external surface; and a second porous layer comprising an inorganic material and having side walls; wherein the first layer is in direct contact with the second layer and wherein the side walls of the first layer and the side walls of the second layer are coated with a third layer of the organic material.. .

04/21/16
20160106782 

Wound healing and tissue engineering


The present invention is directed to wound healing scaffolds cografted with a population of stem cells, wherein the population of stem cells are abcb5+ stem cells. The scaffolds are, for instance, collagen glycosaminoglycan scaffolds..

04/21/16
20160106585 

Implantable intraocular drug delivery apparatus, system and method


The present invention relates to an apparatus, system and method for, and for providing, intraocular delivery of an active agent. The apparatus, system and method may include an implantable scaffold and an active agent associated with the implantable scaffold.

04/21/16
20160106560 

Vascular implant for treating aneurysms


Implants and methods used for the treatment of aneurysms are disclosed. More particularly, embodiments of a vascular implant having several helical scaffolds, each helical scaffold including several undulations having short struts connected to long struts at an undulation joint, are disclosed.

04/21/16
20160106482 

Fracture fixation systems


Systems for bone fracture repair are disclosed. One system includes a biocompatible putty that may be packed about a bone fracture to provide full loadbearing capabilities within days.

04/14/16
20160104882 

Nanocomposite battery electrode particles with changing properties


Battery electrode compositions and methods of fabrication are provided that utilize composite particles. Each of the composite particles may comprise, for example, a high-capacity active material and a porous, electrically-conductive scaffolding matrix material.

04/14/16
20160102324 

New compact scaffold of cas9 in the type ii crispr system


The present invention is in the field of crispr-cas system for genome targeting. The present invention relates to new engineered cas9 scaffolds and uses thereof.

04/14/16
20160102288 

Efficient stem cell delivery into biomaterials using capillary driven encapsulation


Efficient stem cell delivery into biomaterials using capillary driven encapsulation are disclosed herein where stem/progenitor and/or tissue specific cells are rapidly and efficiently seeded via capillary driven encapsulation into a porous scaffold for cell deliver in the skin or any other organ. The rapid capillary force approach maximizes both seeding time and efficiency by combining hydrophobic, entropic and capillary forces to promote active, ‘bottom-up’ cell engraftment.

04/14/16
20160102054 

Hydroxyindole carboxylic acid based inhibitors for oncogenic src homology-2 domain containing protein tyrosine phosphatase-2 (shp2)


Inhibitors of protein tyrosine phosphatases are disclosed. The inhibitors include hydroxyindole carboxylic acids having a linker and an amine scaffold that are potent inhibitors of src homology 2-domain containing protein tyrosine phosphatase-2..

04/14/16
20160101398 

Nanoporous metal-carbon composite


Described here is a metal-carbon composite, comprising (a) a porous three-dimensional scaffold comprising one or more of carbon nanotubes, graphene and graphene oxide, and (b) metal nanoparticles disposed on said porous scaffold, wherein the metal-carbon composite has a density of 1 g/cm3 or less, and wherein the metal nanoparticles account for 1 wt. % or more of the metal-carbon composite.

04/14/16
20160101211 

Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds


According to an illustrative embodiment a method to promote healing of a wound is provided comprising contacting the wound with a biologically active composition comprising a lipoic acid derivative and gelatin. In another embodiment a topical composition is provided, which can be formulated as a homogenous mixture, such as a spray, mist, aerosol, lotion, cream, solution, oil, gel, ointment, paste, emulsion or suspension or applied on a carrier material, such as a bandage, gauze, foam, sponge, hydrogel, hydrocolloid, hydrofiber, occlusive dressing, adhesive composition or scaffold.



Scaffold topics: Nucleotide, Recombinant, Polynucleotide, Amino Acid, Biodegradable, Encapsulation, Surfactant, Enhancement, Monoclonal Antibody, Polypeptide, Immunogenic, Amino Acid Sequence, Monoclonal, Interleukin 2, Immune Disease

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