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 A fluorescent chemical sensor for biological amines patent thumbnailnew patent A fluorescent chemical sensor for biological amines
The invention is provides for a variety of fluorescence sensing compounds characterized generally as having a coumarin-3-aldehyde scaffold with a pendant aryl moiety at the c4-position of the scaffold. The further provides a method for detecting primary amines in a biological sample using said compounds.
The Curators Of The University Of Missouri


 Hydrogen generating system patent thumbnailnew patent Hydrogen generating system
The present invention relates to a solid fuel, a system and a method for generating hydrogen. The solid fuel comprises sodium borohydride, catalyst loaded fibres and a binder, wherein the catalyst loaded fibres and the binder form a scaffold structure within which the sodium borohydride is positioned.
Temasek Polytechnic


 Apparatus and  embedding cable in 3d printed objects patent thumbnailnew patent Apparatus and embedding cable in 3d printed objects
Additive manufacturing method and apparatus for embedding cable in articles of additive manufacture in cooperation with a filament extrusion nozzle to increase their strength and functionality. This capability can be provided autonomously by integrating cable guides and cable cutters with new or existing print heads, enabling them to transition between filament-only, cable-only, and combined cable and filament printing modes to form mechanically stronger objects, integrated circuits within objects, and cable alternatives to filament scaffolding..

 Scaffolds for cell transplantation patent thumbnailnew patent Scaffolds for cell transplantation
A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material..
Regents Of The University Of Michigan


 Coating scaffolds patent thumbnailnew patent Coating scaffolds
Provided are compositions and methods for a scaffold coated with a primer coating and a mineral coating. Also provided is a composition for a scaffold having a mineral coating similar to bone.
Tissue Regeneration Systems, Inc.


 Treatment of skeletal voids with implantable substrate hydrated with bone marrow concentrate patent thumbnailnew patent Treatment of skeletal voids with implantable substrate hydrated with bone marrow concentrate
The invention is directed to a bone void filler comprising a scaffold or matrix. The scaffold or matrix may include a porous inorganic matrix component and/or a 3d-printed implantable device.
Spinesmith Partners, L.p.


 Electronic scaffold and uses thereof patent thumbnailnew patent Electronic scaffold and uses thereof
A device comprising a three-dimensional polymeric element and an electronic element integrated with the polymeric element is disclosed. The electronic element is made up of one or more electrode(s) each individually connectable to a measuring device and/or a controller, and each independently having a thin electrically-isolating layer deposited thereon such that the electrode is exposed to an environment surrounding the electrode at one or more pre-determined locations over the electrode.
Ramot At Tel-aviv University Ltd.


 Photovoltaic device and  manufacture patent thumbnailPhotovoltaic device and manufacture
A photovoltaic device is made by providing a substrate and forming a compact layer on the substrate. The compact layer is coated with a layer including metal oxide nanoparticles and perovskites.
Swansea University


 Nucleic acid-scaffolded small molecule libraries patent thumbnailNucleic acid-scaffolded small molecule libraries
Methods and compositions are provided for identifying novel ligands for a protein target.. .
Albert Einstein College Of Medicine, Inc.


 Target detection with nanopore patent thumbnailTarget detection with nanopore
Provided are methods for detecting a target molecule or particle suspected to be present in a sample, comprising (a) contacting the sample with (i) a fusion molecule comprising a ligand capable of binding to the target molecule or particle and a binding domain, and (ii) a polymer scaffold comprising at least one binding motif to which the binding domain is capable of binding, under conditions that allow the target molecule or particle to bind to the ligand and the binding domain to bind to the binding motif; (b) loading the polymer into a device comprising a pore that separates an interior space of the device into two volumes, and configuring the device to pass the polymer through the pore from one volume to the other volume, wherein the device further comprises a sensor adjacent to the pore configured to identify objects passing through the pore; and (c) determining, with the sensor, whether the fusion molecule or particle bound to the binding motif is bound to the target molecule or particle, thereby detecting the presence of the target molecule or particle in the sample.. .
Two Pore Guys, Inc.


Compounds with (1e, 6e)-1,7-bis-(3,4-dimethoxyphenyl)-4-4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof


The present invention relates to compounds having at least one (substituted phenyl)-propenal moiety. The compounds are useful in treating a subject suffering from an androgen receptor-associated medical condition, e.g., inflammation, acne, alopecia, hirsutism, wound, spinal and bulbar muscular atrophy (sbma, kennedy's disease), unwanted immune response, immune disorder, or cancer..
Allianz Pharmascience Ltd.


Additive manufacturing of building and other structures


Freeform, additive manufacturing equipment, processes and products, including residential, commercial and other buildings. A movable extruder places extrudate that solidifies in open space to create “scaffolding” or “skeletons” of buildings and other products.

Nanofibrous materials for heavy metal adsorption


Water filtration membranes are provided. Such membranes include polysaccharide fibers that have been modified to possess thiol groups thereon, resulting in materials that effectively bind heavy metal ions.
The Research Foundation For The State University Of New York


Improved the administration of a pulmonary surfactant by atomization


The system allows optimizing the dispensing of aerosol medicaments. In particular the system allows the administration of an exogenous pulmonary surfactant to very young patients (e.g.
Chiesi Farmaceutici S.p.a.


Drug delivery scaffold or stent with a novolimus and lactide based coating such that novolimus has a minimum amount of bonding to the coating


Disclosed herein are drug delivery medical devices. A polymer coating for a medical device is provided which comprises a minimum amount of a drug bonded to the polymer in the coating..
Abbott Cardiovascular Systems Inc.


Wnt/beta-catenin inhibitor-eluting endovascular stent


A product comprising a stent for a human blood vessel which comprises (i) a scaffold which is impregnated with, adsorbed with, or coated with an inhibitor of a wnt/p-catenin pathway, or (ii) a scaffold coated with a polymer, which polymer is impregnated with, adsorbed with, or coated with an inhibitor of a wnt/p-catenin pathway, and methods of use to reduce the risk of restenosis.. .
Albert Einstein College Of Medicine, Inc.


Biodegradable supporting device


A biodegradable in vivo supporting device is disclosed. In one embodiment, a coated stent device includes a biodegradable metal alloy scaffold made from a magnesium alloy, iron alloy, zinc alloy, or combination thereof, and the metal scaffold comprises a plurality of metal struts.
Q3 Medical Devices Limited


Tissue repair devices and scaffolds


The present invention relates to multiphasic, three-dimensionally printed, tissue repair devices or scaffolds useful for promoting bone growth and treating bone fracture, defect or deficiency, methods for making the same and methods for promoting bone growth and treating bone fracture, defect or deficiency using the same. The scaffold has a porous bone ingrowth area containing interconnected struts surrounded by a microporous shell.

Stenotic region scoring assembly and method


Assemblies and methods for scoring a stenotic region within a vessel of a patient are disclosed. An assembly can comprise a scoring member and a deployment member.
Vascular Solution, Inc.


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Target detection with nanopore


Provided are methods for detecting a target molecule or particle suspected to be present in a sample, comprising (a) contacting the sample with (i) a fusion molecule comprising a ligand capable of binding to the target molecule or particle and a binding domain, and (ii) a polymer scaffold comprising at least one binding motif to which the binding domain is capable of binding, under conditions that allow the target molecule or particle to bind to the ligand and the binding domain to bind to the binding motif; (b) loading the polymer into a device comprising a pore comprising an opening in a structure that separates an interior space of the device into two volumes, and configuring the device to pass the polymer through the pore from one volume to the other volume, wherein the device further comprises a sensor configured to identify objects passing through the pore; and (c) determining, with the sensor, whether the fusion molecule or particle bound to the binding motif is bound to the target molecule or particle, thereby detecting the presence of the target molecule or particle in the sample.. .
Target Detection With Nanopore


Cannabinoid receptor mediating compounds


A compound, or a pharmaceutically acceptable salt or ester thereof, comprising (i) a cb1 receptor mediating scaffold and (ii) a second therapeutic scaffold.. .
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv


Scaffold-free self-organized 3d synthetic tissue


The present invention can be used for actual implantation surgery without a scaffold. The present invention provides a synthetic tissue or complex which can be produced by culture and has a high level of differentiation ability.
Two Cells, Co., Ltd.


A therapeutic agent delivery arteries


A delivery system for delivery of a therapeutic agent such as stem cells into a vein and across a micro circulation system into an artery comprises a multi lumen catheter for delivery of a therapeutic agent. A discharge device is located in a vein.
Tulip Endovascular Innovation Limited


Stent with elongating struts


A stent includes a plurality of rings which form a tubular scaffold. The rings include an elongation mechanism which allows for further expansion of the stent..
Abbott Cardiovascular Systems Inc.


Tavi anchoring assist device


An implant system may include a delivery sheath having an actuator mechanism, an anchoring assistance device including an expandable scaffold including a mid-body section, a cusp interface section, and a crown end arrangement, and a replacement heart valve implant. The cusp interface section includes a plurality of loop portions arranged at radial intervals about the expandable scaffold.
Boston Scientific Scimed, Inc.


Modular scaffolding horizontal end connector


An end connector for a horizontal scaffold member includes two sidewalls that are substantially parallel joined to a pipe. Each side wall has two spaced apart engagement section.
Excel Modular Scaffold And Leasing Corporation


Tissue scaffolds for electrically excitable cells


Inventive concepts relate generally to nanofibrous scaffolds useful for electrophysiological assays. Scaffolds include polymeric nanofibrous components and electrically excitable cells immobilized at a distinct cell seeding domains on the scaffold.
Innovative Surface Technologies, Inc.


Muscle cell patches and uses therefor


Disclosed herein are contractile cell constructs comprising contractile cells, or progenitors thereof, adhered to a surface of a three dimensional fibroblast containing scaffold (3dfcs) and methods for using them to treat disease. In one aspect, the present invention provides methods for preparing a contractile construct, comprising (a) seeding immature contractile cells onto the surface of a three dimensional fibroblast containing scaffold (3dfcs) to produce a contractile construct; and (b) culturing the contractile construct under conditions to promote differentiation of the immature contractile cells into mature contractile cells, wherein the mature contractile cells form striations.
The United States Government As Represented By The Department Of Veterans Affairs


Resorbable, amino acid-based poly(ester urea)s scaffold for vascular graft tissue engineering


Embodiments relate to amino acid-based poly(ester urea)s with amino acid residues selected l-leucine, l-isoleucine, l-valine or combinations thereof. The amino acid-based poly(ester urea)s may optionally include a second amino acid residue selected from proteinogenic amino acids and non-proteinogenic amino acids.
The University Of Akron


Biomineralization promoting materials and methods of forming same


Bone tissue biomimetic materials, biomimetic constructs that can be formed with the materials, and methods for forming the materials and constructs are described. The bone tissue biomimetic materials include electrospun nanofibers formed of polymers that are conjugated with peptides that include acidic amino acid residues.
University Of South Carolina


Immunogenic polypeptides comprising a scaffold polypeptide and a l2 polypeptide or a fragment thereof


The present invention relates to an immunogenic polypeptide comprising a) a scaffold polypeptide, and b) a l2 polypeptide or a fragment of said l2 polypeptide, wherein said scaffold polypeptide constrains the structure of said l2 polypeptide, or of a fragment of said l2 polypeptide. Moreover, the present invention relates to a vaccine comprising said immunogenic polypeptide.
Dkfz Deutsches Krebsforschungszentrum


Facilitating wireless communications via wireless communication assembly apparatuses


Wireless communication is facilitated via communication assembly apparatuses. A system includes: a wireless gateway device located within a housing and having electrical connection elements for power and network connectivity; and an antenna coupled to the housing and electrically coupled to the wireless gateway device.
At&t Intellectual Property I, L.p.


Nucleic acid sequence assembly


Disclosed herein are compositions, systems and methods related to sequence assembly, such as nucleic acid sequence assembly of single reads and contigs into larger contigs and scaffolds through the use of read pair sequence information, such as read pair information indicative of nucleic acid sequence phase or physical linkage.. .
Dovetail Genomics Llc


Target detection with nanopore


Provided are methods and compositions for detecting a target molecule or particle suspected to be present in a sample using a polymer scaffold, a fusion molecule, and a pore.. .
Two Pore Guys, Inc.


Protein scaffolds and methods of use


This disclosure describes non-naturally occurring protein scaffolds and methods of making and using the protein scaffolds. In one aspect, therefore, this disclosure describes a non-naturally occurring protein scaffold that includes a plurality of structural domains and a plurality of loop regions that include an amino acid sequence that varies from a naturally-occurring loop region by at least one amino acid deletion, substitution, or addition.
Regents Of The University Of Minnesota


Stabilized fibronectin domain compositions, methods and uses


A protein scaffold based on a consensus sequence of fibronectin type iii (fn3) proteins, such as the tenth fn3 repeat from human fibronectin (human tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof, exhibit enhanced thermal and chemical stability while presenting six modifiable loop domains which can be engineered to form a binding partner capable of binding to a target for applications in diagnostic and/or therapeutic compositions, methods and devices.. .
Janssen Biotech, Inc.


Artificial microvascular manufacturing and using the same


Artificial microvascular devices may include a polymer scaffold that defines a channel with a distensible wall.. .
The Charles Stark Draper Laboratory, Inc.


3d printing system comprising solid build ink comprising colorant


A color three-dimensional (3d) printing system includes (1) a solid build ink for each of a plurality of colors, each solid build ink includes (a) a solid acrylate in an amount from about 40 to about 70 percent by weight, (b) a non-curable wax in an amount from about 10 to about 45 percent by weight, (c) a curable wax in an amount from about 1 to about 15 percent by weight, (d) a photoinitiator, and (e) a colorant; each solid build ink has a curing speed adjusted by a ratio of the non-curable wax to curable wax such that the initial curing speed and final hardness of each solid build ink is approximately the same for each of the plurality of colors, and (2) a support material includes the non-curable wax used in each build ink, the support material providing a scaffold for deposition of each build ink.. .
Xerox Corporation


Shape-memory sponge hydrogel biomaterial


A hydrogel biomaterial that can be utilized as a nucleus pulposus replacement material is described. The hydrogel biomaterial can is an elastin-glycosaminoglycan-collagen composite hydrogel biomaterial that can mimic the biochemical and functional characteristics of the human nucleus pulposus.
Clemson University


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Hyaluronic acid and alginate hydrogel composition


A hydrogel composition comprising an alginate polymer and a hyaluronic acid polymer is a useful polymer scaffold for mammalian tissue engineering. To enable cell adhesion, adhesion peptides may be covalently linked to a portion of the alginate and/or hyaluronic acid.
The Regents Of The University Of California


Cardiac prostheses and their deployment


A method of replacing a native cardiac valve with a prosthetic cardiac valve, the method comprising: expanding a wire mesh scaffolding in a chamber of the heart on a retrograde side of the native cardiac valve; while the scaffolding is expanded on the retrograde side of the valve positioning the prosthetic cardiac valve at the site of the native cardiac valve; expanding the prosthetic cardiac valve to replace the native cardiac valve; and collapsing the scaffolding to a collapsed state and removing the collapsed scaffolding from the chamber of the heart.. .
Medical Research, Infrastructure And Health Services Fund Of The Tel Aviv Medical Center


Urethral patency implant


A urethral scaffold is provided for expanding a portion of the urethra that extends through the prostate. The scaffold is expandable and has a plurality of undulating circumferential members disposed between a proximal end and a distal end of the scaffold.
Scaffold Medical Ag


Methods and systems for large scale scaffolding of genome assemblies


Computational methods used for large scale scaffolding of a genome assembly are provided. Such methods may include a step of applying a location clustering model to a test set of contigs to form two or more location cluster groups, each location cluster group comprising one or more location-clustered contigs; a step of applying an ordering model to each of the two or more location cluster groups to form an ordered set of one or more location-clustered contigs within each cluster group; and a step of applying an orienting model to each ordered set of one or more location-clustered contigs to assign a relative orientation to each of the location-clustered contigs within each location cluster group.
University Of Washington


Adjustable scaffolding


An adjustable scaffolding that may adjust to the curvature of a structure. The adjustable scaffolding may comprise a main member, pegs, wing platforms, and rails.
Tarsco Construction Corporation


Method for producing segmental aneuploidy (san) strains of trichoderma reesei via sexual crossing and san strains produced therefrom


The present invention relates to a technology to provide segmental aneuploidy progeny strains of trichoderma reesei. In particular, the present invention relates to a method to produce segmental aneuploidy progeny strains of trichoderma reesei via sexual crossing of two parent haploid strains with chromosome heterozygosity (e.g.
Academia Sinica


Pri-mirna libraries and methods for making and using pri-mirna libraries


Provided are methods for the design, preparation, and use of non-native pri-micrornas (pri-mirnas), pri-microrna (pri-mirna) scaffolds, and libraries of non-native pri-mirnas employing pri-mirna scaffolds. Also provided are methods for identifying non-native pri-mirnas, combinations of two or more non-native pri-mirnas, and mirnas derived from the processing of such non-native pri-mirnas, which mirnas exhibit one or more desired functional activities.

Synthetic single domain antibody


The invention relates to the identification of a highly stable single domain antibody scaffold (hs2d ab) and its use in generating synthetic single domain antibody library (hs2d ab-l1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics..
Centre National De La Recherche Scientifique - Cnrs


Wound cleansing apparatus


An apparatus for cleansing and promoting tissue growth in wounds, in which irrigant fluid optionally containing cell nutrients and/or other physiologically active material from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing, a biodegradable scaffold in contact with the wound bed and a means for fluid cleansing and back to the dressing. The apparatus has means for supplying thermal energy to the fluid in the wound.
Smith & Nephew Plc


Decellularized hyaline cartilage powder for tissue scaffolds


The present invention is related to compositions comprising decellularized cartilage tissue powder in the forms of paste, putty, hydrogel, and scaffolds, methods of making compositions, and methods of using these compositions for treating osteochondral defects and full- or partial-thickness cartilage defects.. .
The University Of Kansas


Flexible stent with torque-absorbing connectors


The present invention concerns an endoprosthesis with a highly flexible structure that is configured to provide an elevated degree of vessel scaffolding and to absorb torque applied on the endoprosthesis. In one embodiment, a method of deploying the endoprosthesis in a body lumen includes locating an endoprosthesis in a contracted delivery configuration in the body lumen, disposing the endoprosthesis in a location of the body lumen to receive the endoprosthesis in an expanded deployed configuration, and deploying the endoprosthesis to transition the endoprosthesis from the contracted delivery configuration to the expanded deployed configuration.
Abbott Laboratories Vascular Enterprises Limited


Synthetic bone grafts constructed from carbon foam materials


A porous, self-sustaining body useful as a scaffold for bone grafting is provided. The scaffold comprises a carbonaceous matrix comprising a continuous phase having a surface and defining a plurality of open spaces throughout the matrix.
Cibor, Inc.


Method and centering a microcatheter within a vasculature


The invention is directed to methods and apparatus for centering a microcatheter within a vasculature. In one aspect, the methods and apparatus can be used to support centering and to facilitate a guidewire to cross through a chronic total occlusion.
Roxwood Medical, Inc.


Suspended scaffolding and suspending device therefore


A suspended scaffold comprises a work platform (6) and at least one suspending device (2) via which the work platform (6) is attachable to an object (1). The suspending device (2) comprises a claw device (3) intended and configured to engage optionally directly on the object (1), and a coupling device (4).
Brand Energy Holdings B.v.


Multiple scaffold design and coating thereof


A multiple stent structure including a plurality of stent bodies arranged end to end in which adjacent stent bodies of the structure are connected by a severable connecting portion disposed between the adjacent stent bodies is disclosed. A method of coating a plurality of stents including depositing a coating on the multiple stent structure and severing the severable connecting portions to disconnect the plurality of stent bodies is disclosed..
Abbott Cardiovascular Systems Inc.


Bone tissue engineering by ex vivo stem cells ongrowth into three-dimensional trabecular metal


Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue..

Biomimetic biphasic 3d nanocomposite scaffold for osteochondral regeneration


The invention describes methods for producing a biphasic nanocomposite scaffold comprising custom polymer-based core-shelled nanospheres by the physical and chemical attachment of two disparate polymeric materials whose composition can be readily modified with tissue-specific nanomaterials and products created using such methods. The custom nanospheres are constructed via co-axial wet electrospraying and can be employed to deliver compounds to the polymeric materials..
The George Washington University, A Congressionally Chartered Not-for-profit Corpor


Scaffold


A scaffold for tissue repair or wound dressing comprising: a material layer; a polymer fibre layer; and an adhesive component between the material layer and the polymer fibre layer, wherein the adhesive component comprises material having a lower melting temperature (tm) than the material layer and the polymer fibre layer.. .
Isis Innovation Limited


Continuous cell programming devices


The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer..
Dana-farber Cancer Institute, Inc.


Scaffolds having radiopaque markers


A scaffold includes a radiopaque marker connected to a strut. The marker is retained within the strut by one or more of a mechanical interference fit, a polymer coating or melt, and/or by friction.
Abbott Cardiovascular Systems Inc.


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Artificial vascular graft


The invention relates to an artificial vascular graft comprising a primary scaffold structure encompassing an inner space of the artificial vascular graft, said primary scaffold structure having an inner surface facing towards said inner space and an outer surface facing away from said inner space, a coating on said inner surface, wherein a plurality of grooves is comprised in said coating of said inner surface. The primary scaffold structure comprises further a coating on said outer surface.
UniversitÄtsspital Basel


Contact lenses having a reinforcing scaffold


Ophthalmic lenses for correcting refractive error of an eye are disclosed. Ophthalmic lenses include an inner optic portion having a scaffold between an anterior portion and a posterior portion.
Nexisvision, Inc.


Telescopic support rod


Systems and methods for adjustable telescopic support rods are provided. Specifically, the telescopic support rods in accordance with some embodiments comprise selectably modifiable indexed lengths having no externally visible indication of the indexing means.

Standing seam mounting brackets


A standing seam mounting bracket and a method of using two or three to provide attachment points along a standing seam roof is provided. The standing seam mounting brackets enable complementary use of commonly-owned equipment for enabling roof maintenance and construction.

Novel polypeptides


The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are specific for the human and rat protease plasma kallikrein and are modified in one or two peptide loops to enhance potency and/or protease resistance..
Bicycle Therapeutics Limtied


3-dimensional cardiac fibroblast derived extracellular matrix


A bioscaffold made from an isolated cardiac fibroblast-derived 3-dimensional extracellular matrix (ecm) is disclosed. The bioscaffold can be used as an epicardial patch for the delivery of therapeutic cells into myocardial tissue.
Wisconsin Alumni Research Foundation


Protein-polymer-drug conjugates


Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (pbrm) and a polymeric carrier substituted with one or more -ld-d, the protein based recognition-molecule being connected to the polymeric carrier by lp.
Mersana Therapeutics, Inc.


Metalloproteinase-cleavable alpha-amanitin-dendrimer conjugates and treating cancer


A conjugate comprising a dendritic polymer or other scaffold, a metalloproteinase-cleavable linker and alpha-amanitin. Methods of using this conjugate for safe targeted treatment of cancer cells expressing metalloproteinases..
King Abdullah International Medical Research Center


Continuous cell programming devices


The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer..
Dana-farber Cancer Institute, Inc.


Continuous cell programming devices


The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer..
Dana-farber Cancer Institute, Inc.


Wall mounted handrail for scaffolding


A handrail assembly for scaffolding comprising a first hand rail component and a second hand rail component, wherein said first hand rail component is slidingly connected to said second hand rail component; a first frame, wherein said first hand rail component is slidingly connected to said first frame; a first wall hook, wherein said first frame is slidingly connected to said first wall hook; a second frame, wherein said second hand rail component is slidingly connected to said second frame; and a second wall hook, wherein said second frame is slidingly connected to said second wall hook.. .

Robotic electroprosessing system and method


The present invention includes a robotic system for the enhanced automation, manipulation, and control of electroprocessing in two or three dimensions. In one embodiment, the system includes a sealed chamber devoid of any electrical or conductive components which would interfere with the electrical field and eventual material fabrication, while still allowing for two-dimensional and three-dimensional robot motion.
Temple University-of The Commonwealth System Of Higher Education


Carbon nanotube compositions and methods of use thereof


Carbon nanotube (cnt)-based compositions for activating cellular immune responses are provided. The cnts function as high surface area scaffolds for the attachment of t cell ligands and/or antigens.
Yale University


Advanced functional biocompatible polymeric matrix containing nano-compartments


The present invention provides a novel biomaterial which is a hybrid, self-assembling biopolymeric networked film that is functionalized through hydrophobic interactions with vesicles loaded with bioactive agents. The biomaterial compound is a polymeric network of hydrophobically modified chitosan scaffolds that is taken from solution and formed as a solid film.
University Of Maryland, College Park


Magnesium alloy implants with controlled degradation


Stents or scaffolds made from magnesium or magnesium alloys including additives or barrier coatings that modify the corrosion rate of the stent are disclosed. Methods of forming barrier coatings that modify the corrosion rate of the stent are disclosed..
Abbott Cardiovascular Systems Inc.


Rigid intervertebral scaffolding


An intervertebral scaffolding system is provided having a central beam having a proximal portion having an end, a grafting portion having a top and a bottom, a distal portion having a end, a central beam axis, a graft distribution channel having an entry port at the end of the proximal portion, a top exit port at the top of the grafting portion, and a bottom exit port at the bottom of the grafting portion. These systems can also include a laterovertically-expanding frame operable for a reversible collapse from an expanded state into a collapsed state.
Ouroboros Medical, Inc.


Interventional device having an integrated embolic filter and associated methods


A percutaneous transluminal device, comprising an elongated catheter, an interventional device operably coupled to the proximal end of the catheter, a filter operably coupled to the distal end of the catheter, the filter movable between a collapsed and deployed position 218, and an actuator wire for deploying the collapsing the filter. The filter including a filter chassis comprising a movable collar a fixed collar and a tubular braided scaffolding coupled between the movable collar and the fixed collar.
Contego Medical, Llc


Method for animal tissue material disinfection and sterilization and corresponding animal tissue soak solution


A method for disinfecting and sterilizing an animal tissue material and a corresponding soak solution for an animal tissue. The method includes placing the animal tissue material into an alkaline soak solution containing a metal peroxide and a detergent, and shaking; removing organic components released from microorganisms and animal tissue cells by soaking and washing in a neutral cleaning solution; washing the tissue matrix with a weak acidic cleaning solution; cryopreserving or freeze-drying the tissue matrix in a neutral solution.
Beijing Ruijian Gaoke Biotechnology Co., Ltd.


Antigen-binding constructs


The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired vh/vl domain, methods of making such constructs and uses thereof.. .
Glaxo Group Limited


High affinity synbodies for influenza


Composition of synbodies that bind influenza. The synbodies are composed of two peptides joined on a scaffold..
Arizona Board Of Regents On Behalf Of Arizona State University


Multivalent heteromultimer scaffold design and constructs


Provided herein are multifunctional heteromultimer proteins. In specific embodiments is a heteromultimer comprising: at least two polypeptide constructs, each polypeptide construct comprising at least one cargo polypeptide attached to a transporter polypeptide, said transporter polypeptides derived from a monomeric native protein such that said monomeric constructs associate to form the heteromultimer and said transporter polypeptides associate to form a quasi-native structure of the monomeric native protein or analog thereof.
Zymeworks Inc.


Cross-linked platelet material


This document provides methods and materials involved in making and using cross-linked platelet material (e.g., cross-linked lysate material from human platelets such as human platelets obtained from platelet blood collection preparations or platelet apheresis preparations). For example, methods and materials for cross-linking platelet material (e.g., lysate material obtained from human platelets) to form a matrix (e.g.
Mayo Foundation For Medical Education And Research


Matrix scaffold for three-dimensional cell cultivation, methods of construction thereof and uses thereof


This invention provides a matrix scaffold for three-dimensional (3d) cell cultivation, a method of its construction, and its uses. The matrix scaffold results from a crosslinking reaction of a fibroin-like substance prepared by a specific method from silk cocoons or filaments, chitosan and crosslinking agents.
Suzhou Cancercell Biotechnology Co. Ltd


Composite support containing silk and collagen, and preparation method thereof


Embodiments of the present invention relate to a biodegradable scaffold for replacing tissue or inducing tissue regeneration and a preparation method thereof, wherein the scaffold comprises at least one woven silk tube layer and a collagen layer inside the tube layer. The scaffold is excellent in terms of tissue regeneration and mechanical properties and causes little or no immune response after implantation.
Dongguk University Industry-academic Cooperation Foundation


Modularly assembled small molecules for the treatment of myotonic dystrophy type 1


To study rna function using small molecules, we designed bioactive, modularly assembled small molecules that target the noncoding expanded rna repeat that causes myotonic dystrophy type 1 (dm1), r(cug)exp. Different modular assembly scaffolds were investigated including polyamines, alpha-peptides, beta-peptides, and peptide tertiary amides (pt as).
The Scripps Research Institute


Three dimensional soy protein-containing scaffolds and methods for their use and production


Porous soy protein-based scaffolds and methods for making the scaffolds using 3d printing techniques are provided. Also provided are tissue growth scaffolds comprising the porous soy protein-based scaffolds and methods for growing tissue on the tissue growth scaffolds.
Northwestern University


Use of compounds with thrombopoietic activity to promote bone growth and healing


Tpo was used to promote the growth of bone in both rats and in mice. Gaps in both mouse and in rat bones were treated with a scaffold sized to fit the gap.
Indiana University Research & Technology Corporation


Engineered integrin binding peptide compositions


Engineered peptides that bind with high affinity (low equilibrium dissociation constant (kd)) to the cell surface receptors of fibronectin (α5β1) or vitronectin (αvβ3 and αvβ5 integrins) are disclosed as useful as imaging tissue. These peptides are based on a molecular scaffold into which a subsequence containing the rgd integrin-binding motif has been inserted.
The Board Of Trustees Of The Leland Stanford Junior University


Stabilized, laterovertically-expanding fusion cage systems


An intervertebral scaffolding system is provided having a laterovertically-expanding frame operable for a reversible collapse from an expanded state into a collapsed state, the laterovertically-expanding frame having a stabilizer that slidably engages with the distal region of the laterovertically-expanding frame and is configured for retaining the laterovertically-expanding frame from a lateral movement that exceeds the expanded state. The expanded state, for example, can be configured to have an open graft distribution window that at least substantially closes upon the reversible collapse..
Ouroboros Medical, Inc.


Systems and methods for managing a patient


Implementations described and claimed herein provide systems and methods for managing one or more patients. In one implementation, an imaging window is determined based on a location of a probe.
Guardsman Scientific, Inc.




Scaffold topics:
  • Nucleotide
  • Recombinant
  • Polynucleotide
  • Amino Acid
  • Biodegradable
  • Encapsulation
  • Surfactant
  • Enhancement
  • Monoclonal Antibody
  • Polypeptide
  • Immunogenic
  • Amino Acid Sequence
  • Monoclonal
  • Interleukin 2
  • Immune Disease


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