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Scaffold-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

Bioabsorbable polymeric composition for a medical device
Orbusneich Medical, Inc.
April 12, 2018 - N°20180099074

A crystallized bioabsorbable polymer scaffold comprises a polymer composition of poly (l-lactide-co-tri-methylene-carbonate) or poly (d-lactide-co-tri-methylene-carbonate) or poly (l-lactide-co-ϵ-caprolactone) or poly (d-lactide-co-ϵ-caprolactone) in the form of block copolymers of blocky copolymers, wherein the scaffold is cold-bendable.
Novel polymyxin derived cell penetrating scaffolds
The Regents Of The University Of California
April 12, 2018 - N°20180099022

Provided are transporters based on polymyxin b. Also provided are methods of using the transporters for intracellular delivery of cargo and methods of enhancing intracellular uptake of cargo.
Laterovertically-expanding fusion cage systems
Integrity Implants Inc.
April 12, 2018 - N°20180098860

An intervertebral scaffolding system is provided having a laterovertically-expanding frame operable for a reversible collapse from an expanded state into a collapsed state, the laterovertically-expanding frame having a stabilizer, one or more tensioners, or a combination of the stabilizer with one or more tensioners. The stabilizer slidably engages with the distal region of the laterovertically-expanding frame and both the stabilizer ...
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Tissue-engineered bowel constructs
Wake Forest University Health Sciences
April 05, 2018 - N°20180093016

Methods are disclosed for forming tissue engineered, tubular bowel constructs from intestinal circular smooth muscle cells and enteric neural progenitor cells. The intestinal smooth muscle cells and neural progenitor cells can be seeded on a mold with a surface texture that induces longitudinal alignment of the intestinal smooth muscle cells and co-cultured until an innervated aligned smooth muscle sheet is ...
System and method for insulin-mimetic of cartilage, bone, or osteochondral repair and piezoelectric composite scaffold
New Jersey Institute Of Technology
April 05, 2018 - N°20180092943

Shown and described is an insulin-mimetic as an inductive agent for cartilage and/or bone repair is disclosed. Sodium tungstate (na2wo4) was utilized as an inductive factor to enhance human mesenchymal stem cell (msc) chondrogenesis. The chondrogenic differentiation of mscs was enhanced in the presence of low concentrations of na2wo4 as compared to control, without na2wo4. Also ...
Novel droplet-embedded microfibers, and methods and devices for preparing and using same
Trustees Of Princeton University
April 05, 2018 - N°20180092861

The invention includes microfluidic methods and devices that allow for the continuous production of microfibers with embedded droplets aligned along the length of the fiber at specific positions. The invention allows for formation of single or multiple emulsions within a fiber. The various phases comprised within the fiber can vary in terms of in terms of hydrophobic/hydrophilic character, solid/...
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Stent including anchoring members
Boston Scientific Scimed, Inc.
April 05, 2018 - N°20180092732

A method for treating an intestine with an expandable scaffolding expanded within the intestine. After placing the expandable scaffolding at a target location, such as across a fistula, the first and second end portions of the expandable scaffolding are radially expanded such that the first and second end portions contact an inner surface of the intestine on opposing sides of ...
Modularly assembled small molecules for the treatment of myotonic dystrophy type 1
The Scripps Research Institute
March 29, 2018 - N°20180089049

Transcriptomes provide a myriad of potential rnas that could be the targets of therapeutics or chemical genetic probes of function. Cell permeable small molecules, however, generally do not exploit these targets, owing to the difficulty in the design of high affinity, specific small molecules targeting rna. As part of a general program to study rna function using small molecules, we ...
Modular roof mounted staging bracket and rail members
March 29, 2018 - N°20180087282

An apparatus for supporting workers and materials above-grade on both the cave and gable ends of a structure is disclosed. The apparatus can be combined with one or more additional staging apparatuses to create a staging system for the support of persons or materials while work is being done on a structure, e. G., roofing, siding, etc. The modular design ...
Hierarchical magnetic nanoparticle-enzyme mesoporous assemblies embedded in macroporous scaffolds
Cornell University
March 29, 2018 - N°20180087043

A hierarchical catalyst composition comprising a continuous or particulate macroporous scaffold in which is incorporated mesoporous aggregates of magnetic nanoparticles, wherein an enzyme is embedded in mesopores of the mesoporous aggregates of magnetic nanoparticles. Methods for synthesizing the hierarchical catalyst composition are also described. Also described are processes that use the recoverable hierarchical catalyst composition for depolymerizing lignin, remediation of ...
Ferromagnetic particles bound to polymeric implants
Yale University
March 29, 2018 - N°20180085496

It has been discovered that iron-platinum magnetic particles can be dispersed in a polymer and coated into or onto, or directly linked to, polymeric materials, especially hydrogels, and magnetized. The magnetized materials are used to attract, capture, and/or retain magnetically labeled cells in the material in vivo. The magnetic particles have an iron/platinum core. Annealing the fe:pt ...
Spatiotemporal delivery system embedded in 3d-printing
The Trustees Of Columbia University In The City Of New York
March 29, 2018 - N°20180085493

Provided herein is a 3d printing system and related compositions, and method of using such, that can produce a polymeric microfiber having embedded microspheres encapsulating an active agent with micron precision and high spatial and temporal resolution. One aspect of the present disclosure provides a method of forming a biocompatible scaffold. Another aspect provides a method of forming a polymeric ...
Antioxidant scaffolds for beta cell delivery
Northwestern University
March 29, 2018 - N°20180085492

Provided herein are thermoresponsive citrate-based hydrogels and methods of use thereof for cell delivery. In particular, pancreatic islet cells entrapped within poly(polyethyleneglycol citrate-co-n isopropylacrylamide) (ppcn) hydrogels are provided herein, as well as methods of use thereof for extra-hepatic islet transplantation.
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Apolipoprotein nanodiscs with telodendrimer
Lawrence Livermore National Security, Llc
March 22, 2018 - N°20180079829

The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula peg-l-d-(r)n, wherein d is a dendritic polymer; l is a bond or a linker linked to the focal point group of the ...
Materials transport device for diagnostic and tissue engineering applications
University Of Georgia
March 22, 2018 - N°20180078932

Devices that can transport biological materials are described. The devices incorporate capillary channeled fibers that can effectively transport living cells as well as other biological materials such as nutrients, growth factors, waste materials, etc. The devices can include a sorptive material at one end of the fibers that can improve transport of materials through the devices. The devices can differentially ...
Controllable self-annealing microgel particles for biomedical applications
The Regents Of The University Of California
March 22, 2018 - N°20180078671

A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs ...
Synergistic glycocalyx treatment compositions and methods
Microvascular Health Solutions, Llc
March 22, 2018 - N°20180078618

Compositions and methods for treating endothelial glycocalyx include glucosamine, hyaluronan and/or fucoidan, and one or more antioxidants, such as superoxide dismutase, catalase, and/or polyphenol. The compositions improve vascular health by exhibiting beneficial synergistic effects on endothelial glycocalyx over the benefits of taking any single component alone or the sum of reported effects of the individual components. Specifically, components ...
Scaffold with scaffold holder receptable and use of an aperture in a scaffold pole
Peri Gmbh
March 15, 2018 - N°20180073258

A facade scaffold includes an inner pole, an outer pole and a scaffold cross-bar between the inner and outer poles. A hollow pole portion of the inner pole has a first receiving through-aperture for a coupling for the attachment of a scaffold holder. A maximum distance between the first receiving through-aperture and a top side of the scaffold cross-bar is ...
March 15, 2018 - N°20180073257

A scaffolding module comprising: a frame that, when in an erected configuration, defines an interior space; and a plurality of mounting regions that allow the module to be mounted with other said scaffolding modules, wherein when so mounted, the module frames are able to be interconnected to form a support structure for one or more scaffolding platforms.
Ang-2 binding modular recognition domain complexes and pharmaceutical compositions thereof
Zyngenia, Inc
March 15, 2018 - N°20180072783

Complexes containing one or more modular recognition domains (mrds) and mrds attached to scaffolds including antibodies are described. The manufacture of these complexes are the use of these complexes to treat and diagnose diseases and disorders are also described.
Selective fkbp51 ligands for treatment of psychiatric disorders
Max-planck-gesellschaft Zur Förderung Der Wissenschaften E.v.
March 15, 2018 - N°20180072667

The present invention relates to compounds having a selective fkbp51 ligand scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said selective fkbp51 ligand compounds can be used for prophylaxis and/or treatment of psychiatric disorders and neurodegenerative diseases, disorders and conditions.