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This page is updated frequently with new Scaffold-related patent applications. Subscribe to the Scaffold RSS feed to automatically get the update: related Scaffold RSS feeds. RSS updates for this page: Scaffold RSS RSS


Multi-functional hybrid devices/structures using 3d printing

Tissue scaffolds derived from forestomach extracellular matrix

Date/App# patent app List of recent Scaffold-related patents
09/11/14
20140257764
 Construction field management method and construction field management device patent thumbnailConstruction field management method and construction field management device
The object is to enable easy acquisition of an element that is not design data. The technique is characterized in that when generating construction field management information used to manage a construction field, a construction field management device acquires measurement data that is three-dimensional shape data measured by a measurement device, and compares design data created by a designer with the acquired measurement data, thus extracting non-design data that is not the design data, from the measurement data.
09/11/14
20140257518
 Multi-functional hybrid devices/structures using 3d printing patent thumbnailMulti-functional hybrid devices/structures using 3d printing
A bioelectronic device and method of making is disclosed. The device includes a scaffold formed via 3d printing.
09/11/14
20140257514
 Bone graft substitute patent thumbnailBone graft substitute
A bone graft substitute in the form of an implantable three-dimensional scaffold that includes calcium phosphate and has pores. The scaffold is impregnated with a calcium and/or phosphate containing substance, and the dissolution rate drs of the scaffold is slower than the dissolution rate drd of the calcium and/or phosphate containing substance..
09/11/14
20140257482
 Tissue scaffolds derived from forestomach extracellular matrix patent thumbnailTissue scaffolds derived from forestomach extracellular matrix
The present invention pertains to the development of extracellular matrix (ecm) scaffolds derived from the forestomach of a ruminant. Such scaffolds are useful in many clinical and therapeutic applications, including wound repair, tissue regeneration, and breast reconstruction.
09/11/14
20140257420
 Shape changing bone implant and method of use for enhancing healing patent thumbnailShape changing bone implant and method of use for enhancing healing
Described is a new bone healing method and class of bone fixation implants that change shape once implanted so as to minimize non-healing and speed the bone healing process. The bone fixation method involves shape changing implants that continuously hold the bones in apposition so that a gap does not form.
09/11/14
20140256817
 Amphipathic and other double-sided alpha-helix mimetics based on a 1,2-diphenylacetylene scaffold patent thumbnailAmphipathic and other double-sided alpha-helix mimetics based on a 1,2-diphenylacetylene scaffold
Small-molecule scaffolds based on 1,2-diphenylacetylene that accurately replicate the spatial and angular projections of several side chains on both faces of an α-helix, specifically the i and i+7 side chains on one face, and the i and i+2 side chains on the other. The amphipathic α-helix mimetic can be used to disrupt disease-promoting protein-protein interactions that are mediated by α-helices..
09/11/14
20140255939
 Nucleic acid-based linkers for detecting and measuring interactions patent thumbnailNucleic acid-based linkers for detecting and measuring interactions
The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics with or without force, detecting analytes, screening aptamers, and encoding/encrypting information. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides.
09/11/14
20140255246
 Medical device having niobium nitinol alloy patent thumbnailMedical device having niobium nitinol alloy
Guide wire devices and other intra-corporal medical devices fabricated from a ni—ti—nb alloy and methods for their manufacture. The ni—ti alloy includes nickel, titanium, and niobium either up to its solubility limit in ni—ti, or in amounts over 15 atomic percent so as to provide a dual phase alloy.
09/11/14
20140255086
 Coupling member for scaffoldings patent thumbnailCoupling member for scaffoldings
A coupling member includes a hook-shaped coupling part arranged to be hooked into a gripping part of an upright and a locking arrangement switchable between a locking position and a release position. Further, the locking arrangement includes a pivotally attached first clamping part and a wedge-shaped locking part, which is slidable between a locking position and a release position.
09/11/14
20140252675
 Medical device fabrication process including strain induced crystallization with enhanced crystallization patent thumbnailMedical device fabrication process including strain induced crystallization with enhanced crystallization
Methods of fabricating a polymeric implantable device, such as a stent, with improved fracture toughness through annealing a polymer construct below the glass transition temperature of the polymer of the construct prior to a deformation step are disclosed herein. The deformation of the construct induces crystallization in the polymer construct through strain-induced crystallization.
09/11/14
20140250667
Methods for crimping a polymeric stent scaffold onto a delivery balloon
A medical device includes a polymer stent scaffold crimped to a catheter having an expansion balloon. A process for forming the medical device includes placing the scaffold on a support supported by an alignment carriage, and deionizing the scaffold to remove any static charge buildup on the scaffold before placing the scaffold within a crimper to reduce the scaffold's diameter.
09/04/14
20140249619
Electrospun ptfe coated stent and method of use
A stent or other prosthesis may be formed by coating a single continuous wire scaffold with a polymer coating. The polymer coating may consist of layers of electrospun polytetrafluoroethylene (ptfe).
09/04/14
20140249513
Tissue harvesting
The present disclosure relates to a tissue collection apparatus including a housing defining an inlet and an outlet and a tissue scaffold suitable for disposal within the housing, the tissue scaffold configured to be loaded with the tissue under the application of an aspiration force applied through the tissue collection apparatus.. .
09/04/14
20140249511
Catheter apparatus and methods for treating vasculatures
A catheter apparatus may have a flexible shaft, guidewire lumens passing through the shaft, and a positioning device for positioning the guidewires relative to an external lumen. The positioning device may be an expansible scaffold covered with a retractable sheath.
09/04/14
20140249292
Modulation of structured polypeptide specificity
The invention describes a method for selecting a polypeptide ligand having a desired level of specificity for a target, wherein the polypeptide ligand comprises a polypeptide comprising at least three reactive groups, separated by at least two loop sequences, and a molecular scaffold which forms covalent bonds with the reactive groups of the polypeptide such that at least two polypeptide loops are formed on the molecular scaffold, comprising (i) screening at least two different sets of polypeptide ligands against the target, and selecting one or more ligands from each library which interact with the target; (ii) comparing the activity of the selected ligands with one or more paralogues or orthologues of the target; and (iii) further selecting one or more ligands according to their activity towards said one or more paralogues or orthologues; wherein said two or more different sets of ligands differ in the length of the polypeptide loops formed on the molecular scaffold.. .
09/04/14
20140248418
Electrospun ptfe coated stent and method of use
A stent or other prosthesis may be formed by coating a single continuous wire scaffold with a polymer coating. The polymer coating may consist of layers of electrospun polytetrafluoroethylene (ptfe).
09/04/14
20140248268
Rab7 gtpase inhibitors and related methods of treatment
This invention relates to compounds and their use as inhibitors or activators of rab7 gtpase to treat or prevent the onset of rab 7 gtpase-associated disorders such as neuropathies, cancer, metabolic diseases of bone and lipid storage. The invention is also applicable to infectious diseases where rab7 is inactivated or its protein-protein interactions are modulated to facilitate intracellular survival of pathogens.
08/28/14
20140243995
Stacked planar sheet tissue engineering scaffolds with 3d structural order
A three-dimensional tissue engineering scaffold device and related methods are disclosed herein. The tissue engineering scaffold includes a plurality of polymers sheets.
08/28/14
20140243979
System and method for forming bone, ligament, and bone-ligament constructs
A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in vitro in osteogenic media such that the cells form a confluent monolayer and detach from the substrate to form a self-organized three-dimensional bone construct. A system and method for forming a ligament construct using fibrogenic media and a system and method for forming a functionally integrated bone-ligament construct are also provided..
08/28/14
20140243966
Anti-paravalvular leakage component for a transcatheter valve prosthesis
A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold.
08/28/14
20140243708
Sampling device
A medical sampling device, a method of manufacturing the device, and methods of testing and diagnosis using the device; a sampling dressing comprising the device, a method of manufacturing the dressing, and a method of diagnosis using the dressing; and a therapy dressing comprising the device, a method of manufacturing the dressing, and a method of treatment using the dressing. The a sampling device comprises a biodegradable porous scaffold which in use lies in contact with tissue to be sampled and comprises a fluid, in particular a reversibly thermoswitchable gel..
08/28/14
20140242602
Uses of labeled hsp90 inhibitors
The disclosure provides evidence that the abundance of this particular “oncogenic hsp90” species, which is not dictated by hsp90 expression alone, predicts for sensitivity to hsp90 inhibition therapy, and thus is a biomarker for hsp90 therapy. The disclosure also provides evidence that identifying and measuring the abundance of this oncogenic hsp90 species in tumors predicts of response to hsp90 therapy.
08/28/14
20140242551
Oral care system and method
An oral care system and method for the treatment of certain oral pathological conditions that require the cleaning and cleansing of the underlying scaffolding of the tooth. The oral care system and method generally includes applying chlorine dioxide liquid or gel to a diseased portion of the tooth and activating it so as to clean the aforementioned.
08/28/14
20140242347
Graft for directed vascular and lymphatic regeneration and methods to guide endothelial cell assembly
Embodiments of the present invention relate to a therapeutic device (graft) comprising a collagen membrane having an aligned uniaxial or biaxial structure such that mammalian cells plated on the membrane align mainly along the direction of the collagen fibrils. In a further aspect, a graft comprising a substantially tubular body, wherein the body has an exterior surface, an interior surface, and at least one lumen extending therethrough such that a fluid flow through the lumen can direct mammalian cell migration.
08/28/14
20140242184
Compositions for regenerating defective or absent myocardium
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function..
08/28/14
20140242183
Compositions for regenerating defective or absent myocardium
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function..
08/28/14
20140242144
Drug eluting scaffold for kidney-related disease
Methods of treating renal cancers and other kidney-related inflammatory disorders with a bioabsorbable polymer scaffold (such as a stent) are described. The treatments are provided as alternative to complete or partial surgical removal of a diseased kidney..
08/28/14
20140242143
Adipose stromal vascular fraction cell constructs
Three-dimensional tissue constructs are described, which may be created by isolating adipose-derived stromal vascular fraction (svf) cells, plating the cells onto a polymer scaffold, and culturing the plated scaffold in a culture of dmem with approximately 10% fbs.. .
08/28/14
20140242065
Compositions for regenerating defective or absent myocardium
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function..
08/28/14
20140238306
Nesting material baling and dispensing system for mouse environmental enrichment
A standardized nesting material for use in laboratory environments for rodents includes a latrining substrate, and at least one bale unit formed to include a fibrous scaffolding material, and an insulating material. The bale units are of standardized size and can be packaged and sterilized to provide improved wellbeing of the animals; reduced feed and labor costs; and improved scientific quality of the studies conducted on the animals..
08/21/14
20140236312
Cortical bone scaffold for guided osteon regeneration in load-bearing orthopaedic applications
Described is an artificial bone scaffold with an architecture resembling cortical bone, including microchannel-like structures resembling osteons. The scaffold enhances the ability of osteoblasts to secrete organized collagen and mineralize extracellular matrix within the osteon-like channels, thus promoting scaffold strength..
08/21/14
20140236299
Porous composite biomaterials and related methods
Synthetic composite materials for use, for example, as orthopedic implants are described herein. In one example, a composite material for use as a scaffold includes a thermoplastic polymer forming a porous matrix that has continuous porosity and a plurality of pores.
08/21/14
20140236281
Apparatus for manufacturing scaffold and scaffold manufactured by the same
In an apparatus for manufacturing a scaffold and a scaffold manufactured by the apparatus, a collector is disposed under a dispensing head that dispenses melted bio materials (polymer) for manufacturing the scaffold. The collector has a cylindrical tube shape.
08/21/14
20140235872
Novel low molecular weight cationic lipids for oligonucleotide delivery
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and peg-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver.
08/21/14
20140234953
Fabrication of vascularized tissue using microfabricated two-dimensional molds
Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells.
08/21/14
20140234423
Programming of cells for tolerogenic therapies
Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease..
08/21/14
20140234388
Bioscaffolds for formation of motor endplates and other specialized tissue structures
Provided herein are scaffolds and methods useful to promote the formation of functional clusters on a tissue, for example, motor endplates (meps) or a component thereof on skeletal muscle cells or tissue, as well as the use of scaffolds so produced for repairing a tissue injury or defect.. .
08/21/14
20140234381
Scaffold for subretinal cell transplantation and drug delivery
The following disclosure provides compositions and methods for the repairing of a diseased or disordered retina, for example, in patients suffering from age-related macular degeneration (amd).. .
08/21/14
20140234221
Antigen-binding proteins comprising recombinant protein scaffolds
Disclosed herein are recombinant protein scaffolds and recombinant multifunctional protein scaffolds for use in producing antigen-binding proteins in addition, nucleic acids encoding such recombinant protein scaffolds, recombinant multifunctional protein scaffolds, and antigen-binding proteins are provided vectors and cells useful for expression of the described proteins are also provided, as are methods of use.. .
08/21/14
20140234014
Pivoting horizontal and vertical scaffold members and a method of erecting an offset scaffold platform
One embodiment of the invention is a horizontal scaffold truss that has upper and lower horizontal scaffold members offset but fixedly joined with braces. Each upper and lower members have a connector positioned on each end of the respective lower and upper members, where at least one of the connectors is pivotally mounted on the respective lower or upper connector, and the connectors are engagable with an annular member positioned on a vertical scaffold member..
08/21/14
20140230227
Methods for crimping a polymeric scaffold to a delivery balloon and achieving stable mechanical properties in the scaffold after crimping
A medical device-includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes inflating the delivery balloon during a diameter reduction to improve scaffold retention.
08/14/14
20140228970
Tissue engineering device and construction of vascularized dermis
An inkjet printing method, system, and computer-usable tangible storage device to print cells and biomaterials for three-dimensional cellular scaffolds and engineered skin grafts are disclosed. The process simultaneously deposits living cells, nutrients, growth factors, therapeutic drugs along with biomaterial scaffolds at the right time and location.
08/14/14
20140228953
Ear scaffold
A scaffold for reshaping the cartilaginous portion of an ear. The scaffold is formed of shape memory material and in the form of a horseshoe shape, or is formed from a thermoplastic pliable material..
08/14/14
20140228932
Methods of treatment directed to neointimal proliferation generated by endothelial shear stress patterns from drug-eluting bioresorbable vascular scaffold implantation
Treatments of coronary heart disease including the effect of endothelial shear stress (ess) on neointimal formation following a bioresorbable vascular scaffold implantation are disclosed.. .
08/14/14
20140228930
Modified scaffolds for peripheral applications
Stent scaffolds that include a polymeric structure or structures bonded to the scaffold and extending along their length are disclosed. The polymeric structure extends across some or all of the gaps in struts along the length of the scaffold.
08/14/14
20140228893
Bone plate positioning scaffold
A device to maintain temporary engagement with a bone plate and a bone, the device comprising a first biased appendage positioned opposite a second biased appendage, the first and second biased appendages including an arcuate vertical profile that partially defines an interior region; a platform concurrently coupled to the first and second biased appendages, the platform also partially defining the interior region, the platform including a through hole open to the interior region; a first tab extending from at least one of the first biased appendage, the second biased appendage, and the platform, the first tab extending into the interior region and adapted to engage a bone plate; a first arcuate flange mounted to a distal portion of the platform; and a second arcuate flange mounted to a proximal portion of the platform.. .
08/14/14
20140227783
Methods and apparatus for building complex 3d scaffolds and biomimetic scaffolds built therefrom
A novel method for building complex three-dimensional scaffolds for biomimetic applications such as in vitro organ growth, using a gelatin/sugar/water gel, ultraviolet radiation, and heat or enzyme is described. The method produces gelatin-sugar hydrogels demonstrating greater thermal stability, mechanical strength, and resistance to enzymatic degradation.
08/14/14
20140227782
Thermosensitive, bioactive biopolymer and associated method of cell harvesting
The present invention relates to a biopolymer and a cell-harvesting scaffold comprising same, as well as the associated cell-harvesting method that allows said harvesting to be performed in a simple and effective manner by reducing the culture temperature. The present invention also relates to a method for synthesising said biopolymer..
08/14/14
20140227364
Methods of manufacturing bioactive gels from extracellular matrix material
The present invention is directed to methods of manufacturing bioactive gels from ecm material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ecm material can be created by digesting particularized ecm material in an alkaline environment and neutralizing to provide bioactive gels..
08/14/14
20140227362
Methods of manufacturing bioactive gels from extracellular matrix material
The present invention is directed to methods of manufacturing bioactive gels from ecm material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ecm material can be created by digesting particularized ecm material in an alkaline environment and neutralizing to provide bioactive gels..
08/14/14
20140227339
Regenerative tissue grafts and methods of making same
A graft containing a scaffold that includes a matrix in which are positioned mesenchymal progenitor cells (mpcs) has the capacity to substantially improve wound healing, including wounds resulting from injury to nerve, bone and vascular tissue. Mpcs can be harvested from debrided muscle tissue following orthopaedic trauma.
08/14/14
20140227336
Tissue engineering methods and compositions
Cells are employed in conjunction with unique biologically-compatible scaffold structures to generate differentiated tissues and structures, both in vitro and in vivo. The presently disclosed subject matter further relates to methods of forming and using improved tissue engineered scaffolds that can be used as substrates to facilitate the growth and differentiation of cells..
08/07/14
20140222152
Implantable intervertebral disc devices and uses thereof
Provided herein are implantable intervertebral disc devices, and methods of making the same. For example, an implantable intervertebral disc device comprises an engineered annulus fibrosus (af) scaffold that can mimic its native-like cross alignment of pores/channels within the af region, and can be served as a scaffolding material for cell and matrix alignment.
08/07/14
20140222144
Anti-paravalvular leakage component for a transcatheter valve prosthesis
A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold.
08/07/14
20140222135
Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of same
Prosthetic valves and their component parts are described, as are prosthetic valve delivery devices and methods for their use. The prosthetic valves are particularly adapted for use in percutaneous aortic valve replacement procedures.
08/07/14
20140221615
Porous scaffold material, and method for producing same
Provided are a scaffold material that functions as a scaffold material for two weeks or more in vivo and causes substantially no foreign-body reaction, and a method for producing the scaffold material. Specifically, a porous scaffold material comprising collagen fibers is provided..
08/07/14
20140221569
Decorated macromolecular scaffolds
The present invention relates to a method for preparing decorated macromolecular scaffolds. The method of the invention is useful for the generation of bioactive nanoparticles for use in clinical applications.
08/07/14
20140220496
Method of forming photoresist structure
A method for forming a photoresist structure is provided the method includes the step of forming a photoresist layer on a substrate, the step of exposing a portion of the photoresist layer to form an exposed portion of the photoresist layer, and the step of removing the photoresist layer except the exposed portion with a solvent, so as to form the photoresist structure, wherein the photoresist layer has a polymer having a structure represented by formula (i). The method of the present invention can generate a photoresist with an even thickness on devices with complex geometries or three-dimensional substrates.


Popular terms: [SEARCH]

Scaffold topics: Nucleotide, Recombinant, Polynucleotide, Amino Acid, Biodegradable, Encapsulation, Surfactant, Enhancement, Monoclonal Antibody, Polypeptide, Immunogenic, Amino Acid Sequence, Monoclonal, Interleukin 2, Immune Disease

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This listing is a sample listing of patent applications related to Scaffold for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Scaffold with additional patents listed. Browse our RSS directory or Search for other possible listings.
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