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Scaffold patents

This page is updated frequently with new Scaffold-related patent applications. Subscribe to the Scaffold RSS feed to automatically get the update: related Scaffold RSS feeds. RSS updates for this page: Scaffold RSS RSS

Date/App# patent app List of recent Scaffold-related patents
 Biomaterials with microsphere gradients and core and shell microspheres patent thumbnailnew patent Biomaterials with microsphere gradients and core and shell microspheres
Methods can prepare tissue engineering scaffolds that include a plurality of biocompatible core/shell microspheres linked together to form a three-dimensional matrix. The matrix can include a plurality of pores for growing cells.
 Biodegradable apparatus and method for closure of trocar defects patent thumbnailnew patent Biodegradable apparatus and method for closure of trocar defects
A biodegradable device for providing scaffolding for a trocar defect to promote healing. The device consists of an upper and lower scaffold, offset by a connector.
 Transgenic system for reversibly immortalizing mammalian quiescent cells patent thumbnailnew patent Transgenic system for reversibly immortalizing mammalian quiescent cells
A transgene for endowing human quiescent cells from primary cultures with exogenously inducible telomere length homeostasis and cell cycle traverse is described. The transgene includes at least three promoter sequences; a g1-specific rna interference sequence which is operably linked downstream of a first promoter sequence; a telomere length maintenance gene sequence which is operably linked downstream to a second promoter sequence; a scaffold/matrix attachment region (s/mar) element positioned downstream in frame with said telomere length maintenance gene sequence and an exogenously-inducible transcriptional regulation system.
 Inkjet printing of tissues and cells patent thumbnailnew patent Inkjet printing of tissues and cells
Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided.
 Silk covered breast implant patent thumbnailSilk covered breast implant
The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such molecules, methods of making fibroin hydrogels, fibroin hydrogels and fibroin hydrogel formulations useful for a variety of medical uses, including, without limitation uses as bulking agents, tissue space fillers, templates for tissue reconstruction or regeneration, cell culture scaffolds for tissue engineering and for disease models, surface coating to improve medical device function, or drug delivery devices.. .
 Metamaterial optical elements self-assembled on protein scaffolds patent thumbnailMetamaterial optical elements self-assembled on protein scaffolds
A genetically modified cowpea mosaic virus (cpmv) protein capsid serves as a scaffold for metal nanoparticles, preferably gold nanospheres, of 15 nm to 35 nm, creating plasmonic nanoclusters. The self-assembled nanoclusters gave rise to a 10-fold surface-averaged enhancement of the local electromagnetic field.
 In situ antigen-generating cancer vaccine patent thumbnailIn situ antigen-generating cancer vaccine
The invention provides compositions and methods for utilizing scaffolds in cancer vaccines.. .
 Methods for preparation of neo-cartilage constructs patent thumbnailMethods for preparation of neo-cartilage constructs
The invention generally relates to systems (i.e. Constructs) for repairing cartilage and methods for preparing the same that introduce a bioactive agent into a culture medium, suspension, scaffold, solution incorporated into the pores of the scaffold, or combinations thereof.
 Post-crimping inspection of scaffolds mounted on scaffold delivery systems patent thumbnailPost-crimping inspection of scaffolds mounted on scaffold delivery systems
A system for mounting a scaffold on a balloon catheter includes two positioning and alignment stations, which are used to prepare a scaffold and catheter for crimping using the same crimping head. The system is configured for automated assembly of the scaffold and catheter prior to crimping and performing post-crimping inspection for the crimped scaffold and prior to placing a restraining sheath over the crimped scaffold..
 Demineralized cancellous bone scaffolds patent thumbnailDemineralized cancellous bone scaffolds
The present invention provides a cancellous bone scaffold to use in the replacement or repair of connective tissue such as ligaments and tendons. The cancellous bone scaffold has a fully demineralized segment with at least one adjacent mineralized end segment..
Fibrous scaffold for use in soft tissue engineering
The present invention relates to a fibrous scaffold for use as a substrate in soft tissue applications, in particular for preparing annulus fibrosus (af) tissue. In aspects, the present invention also relates to an engineered biological material comprising af tissue; constructs comprising one or more engineered biological materials; methods for producing the biological materials and constructs; and methods of using the biological materials and constructs..
Methods for maintaining pegylation of polypeptides
Described herein are methods for maintaining pegylation and inhibiting depegylation of polypeptides, such as fibronectin-based scaffold proteins, during storage.. .
Scaffold-free tissue constructs
A tissue construct comprising includes a self-assembled, scaffold-free, high-density cell aggregate. The cell aggregate includes a plurality of cells and a plurality of biocompatible and degradable nanoparticles and/or microparticles that are incorporated within the cell aggregate.
Tissue repair system
An implant for promoting accelerated wound healing. The implant comprises a non-flocculating fiber material, admixed with a settable fluid.
Preparation method of core-shell structured fibrous scaffolds
The present invention relates to a preparation method for core-shell structured fibrous scaffolds, and more specifically to preparing a core part composition and a shell part composition that each have different constitutions by adding calcium phosphate cement and a protein, drug of combination thereof to alginate solution, and then inserting the above core part composition and shell part composition to internal and external nozzle of concentric nozzle respectively to inject into calcium ion aqueous solution and thereby hardening them, thus preparing core-shell structured rapidly setting alg/α-tcp scaffolds capable of controllably releasing a protein or drug.. .
Methods and compositions for the treatment, prevention, and alleviation of bone and cartilage diseases or injuries and hair loss
The present invention provides pharmaceutical compositions, and methods of preparation and use for the treatment, prevention or alleviation of bone and cartilage diseases or injuries and hair loss. The present invention discloses a method and a pharmaceutical composition comprising mesenchymal stem cells, platelets, activating factors and scaffolding materials for the treatment, prevention, or alleviation of bone diseases, bone injuries or hair loss, and a method and a pharmaceutical composition further comprising dexamethasone for the treatment, prevention, or alleviation of cartilage diseases or injuries..
Compositions for regenerating defective or absent myocardium
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function..
Dynamic bioactive nanofiber scaffolding
A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material.
Tissue engineered fibrocartilage replacement
Fibrocartilage implants characterized by circumferential fiber networks embedded in arcuate or torroidal scaffolds with orthogonal fiber networks embedded therein to prevent separation of the circumferential fiber networks. The fiber networks convert axial compressive forces on the scaffolds to tensile loads on the circumferential fibers.
Thermosensitive and crosslinkable polymer composite for three-dimensional soft tissue scaffold printing
A hydrogel material for use in three-dimensional scaffold printing is disclosed. The material is formed from a first triblock polymer having a formula aba and a second triblock polymer having a formula amabama, wherein a is a first polymer, b is a second polymer, and ama is a methacrylate of the first polymer.
Prna mutlivalent junction domain for use in stable multivalent rna nanoparticles
Trifurcate rna junction domains derived from phi29 prna are described that assemble with high affinity and that are stable in vitro and in vivo. Further expansion of trifurcated rna domains to multiple way junction scaffolds via creative designs enable an array of toolkit to construct nanoparticle architectures with diverse shapes and angles.
Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
Wherein the groups a, b, x, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (hsd) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia..
Compositions for regenerating defective or absent myocardium
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function..
Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation
The invention provides polymer scaffolds for cell-based tissue engineering.. .
Gradient porous scaffolds
The present invention provides gradient porous scaffolds for bone regeneration and osteochondral defect repair, methods for making such gradient porous scaffolds, and methods for using the gradient porous scaffolds.. .
Continuous culturing device
A continuous device for culturing mammalian cells in a three-dimensional structure for the transplantation or implantation in vivo is described. The culturing device comprises (a) a scaffold formed by a matrix of interconnected growth surfaces spaced at regular intervals and (b) a fluid distribution means at the inlet and the exit of the growth areas.
Antibody-like proteins for therapeutic and diagnostic use
Disclosed herein are recombinant protein scaffolds for use in producing antigen-binding proteins. Related antigen-binding proteins are also provided herein.
Cellular compositions for tissue engineering
Cell compositions for tissue engineering are provided which contain a population of autologous, minimally passaged dermal fibroblasts in combination with a tissue engineering matrix or scaffold, or material forming a matrix or scaffold. In one embodiment, the population of fibroblasts is genetically engineered to secrete a therapeutic protein in an amount effective to induce tissue growth or tissue repair when the cell composition is transplanted into a subject in need thereof.
Method of fabricating a porous orthopedic implant
A tissue scaffold fabricated from bioinert fiber forms a rigid three-dimensional porous matrix having a bioinert composition. Porosity in the form of interconnected pore space is provided by the space between the bioinert fiber in the porous matrix.
Draw-ahead feature for biological sequence drawing applications
Embodiments described herein allow a user to electronically draw and edit a biological sequence and its resulting structure. Embodiments may include identifying, based at least in part upon an amended in-progress biological sequence, one or more biological sequence scaffold candidates from a set of biological sequence scaffold candidates, where each biological sequence scaffold candidate of the one or more biological sequence scaffold candidates is configured to, upon one or both of (i) appending to the amended portion of the in-progress biological sequence and (ii) replacing or partially replacing the amended portion of the in-progress biological sequence, provide a resulting biological sequence or biological sequence fragment that has been previously rendered.
Draw-ahead feature for chemical structure drawing applications
Systems, methods, and apparatus are provided that allow a user to draw and edit a chemical structure. Aspects of the present disclosure may include receiving an input corresponding to an amendment to a portion of an in-progress chemical structure, and identifying, based at least in part upon the amended in-progress chemical structure, one or more molecular scaffolds from a set of candidate molecular scaffolds.
Biocompatible extremely fine tantalum fiber scaffolding for bone and soft tissue prosthesis
A tissue implant member for implanting in living tissue is provided. The implant is formed of a fibrous structure of tantalum filament having a diameter less than 5 microns..
Intervertebral scaffolding system
An intervertebral scaffolding system is provided having a central beam having a proximal portion having an end, a grafting portion having a top and a bottom, a distal portion having a end, a central beam axis, a graft distribution channel having an entry port at the end of the proximal portion, a top exit port at the top of the grafting portion, and a bottom exit port at the bottom of the grafting portion. These systems can also include a laterovertically-expanding frame operable for a reversible collapse from an expanded state into a collapsed state.
Neural scaffolds
Disclosed herein are compositions and methods useful for preparing neural scaffolds. The scaffolds comprise tissue taken from the spinal cord and/or dura mater of vertebrate and can be processed to form gels or sheets.
Fabrication of bone regeneration scaffolds and bone filler material using a perfusion flow system
The present disclosure is directed at a process to form bone grafting material. One may provide a porous collagen scaffold and insert the scaffold into a perfusion chamber of a perfusion flow system.
Arthroscopic tissue scaffold delivery device
A small diameter delivery device capable of delivering a tissue loaded scaffold arthroscopically to a tissue defect or injury site without reducing the pressure at the injury site is provided. The scaffold delivery device of the present invention comprises a plunger system that includes two main components: an insertion tube and an insertion rod.
Multispecific peptides
The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.. .
Inhibitors of anandamide transport and their therapeutic uses
Nucleic acid and polypeptide sequences corresponding to flat, a partly cytosolic variant of the intracellular anandamide-degrading enzyme, fatty acid amide hydrolase-1 (faah-1), are provided. Flat lacks amidase activity but binds the endocannibinoid anandamide and facilitates its transport into cells.
Scaffold-kinase interaction blockades and uses thereof in treating cancer
Aspects of the invention include compositions and methods for inhibiting the interaction between scaffold proteins and kinases. These compositions and methods find a number of uses including, for example, suppressing tumor growth and metastasis and reducing tumor size and number in a mammal with cancer..
Compositions for regenerating defective or absent myocardium
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function..
Pederin and psymberin agents
Compounds that include a pederin, psymberin or pederin/psymberin chimera scaffold. The pederin scaffold includes a substituent at the c10 and/or c13 position that may include a linker that may be conjugated to a targeting moiety.
Dynamic macropore formation using multiple porogens
Macroporous 3-d tissue engineering scaffold are manufactured by contacting an article comprising multiple distinct macroparticulate porogens distributed within a polymer scaffold, wherein the porogens are selectively and sequentially dissolvable by corresponding biocompatible stimuli.. .
Hybrid tissue scaffold for tissue engineering
A hybrid tissue scaffold is provided which comprises a porous primary scaffold having a plurality of pores and a porous secondary scaffold having a plurality of pores, wherein the secondary scaffold resides in the pores of the primary scaffold to provide a hybrid scaffold. The pores of the porous primary scaffold may have a pore size in a range of 0.50 mm to 5.0 mm, and the pores of the porous secondary scaffold may have a pore size in a range of 50 μm to 600 μm.
Ice-tempered hybrid materials
A metal-polymer composite scaffold includes metal particles coupled with polymer binder, the scaffold having regions of aligned porosity with a gradient. In a particular embodiment, the metal particles include stainless steel.
Sheaths reducing recoil and loss of retention for polymer scaffolds crimped to balloons
A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. A single piece sheath is placed over the scaffold immediately following crimping of the scaffold to the balloon.
Bispecific asymmetric heterodimers comprising anti-cd3 constructs
Disclosed herein are isolated multi-specific heteromultimer constructs that bind to cd3 expressed on t-cells and to an antigen expressed on b-cells. The multi-specific heteromultimer constructs are capable of bridging t- and b-cells and mediating killing of b-cells.
Self-jacking scaffold for large cylindrical tanks
An apparatus and method for raising a self-jacking scaffold system including extending a jacking screw and jacking screw bracket axially upward, connecting a jacking screw bracket to an overhead tank bracket for a plurality of scaffold sections coupled to a jacking assembly, detaching a plurality of scaffold mounting brackets from a plurality of tank mounting brackets, raising the continuously coupled plurality of scaffold sections, and reattaching the plurality of scaffold mounting brackets to a plurality of tank mounting brackets. Noting the plurality of scaffold sections is continuously coupled proximate a circumference of a shell tank, the continuously coupled scaffold sections and tank mounting brackets provide stiffness to the tank shell to enable it to resist external loads and can be quickly moved and restored as required during tank construction..
Generating ck19-positive cells with hair-like structures from whartons jelly
A method of differentiating cells into ck19-positive cells capable of producing hair follicle-like and hair structure-like can include: providing a tissue scaffold; seeding cells into the scaffold, the cells being capable of differentiation; incubating the scaffold having the cells in a cell growth media; and incubating the scaffold having the cells in an osteogenic differentiation medium sufficient for ck19-positive cells to be generated in the scaffold. The tissue scaffold can be a decellularized whartons' jelly matrix.
Ecm constructs for tissue regeneration
An extracellular matrix (ecm) construct comprising a biodegradable support scaffold that includes a plurality of biodegradable microneedles that are capable of piercing tissue and anchoring therein, and at least a first layer of ecm material disposed on the top surface of the support scaffold. In some embodiments, the microneedles are capable of administering a pharmacological composition to the engaged tissue..
Generation and expression of engineered i-onui endonuclease and its homologues and uses thereof
The present disclosure provides compositions and methods for producing and expressing variant or engineered i-onui endonucleases, variant or engineered i-onui homologues, and hybrids of two i-onui or i-onui homologue domains that have a target site altered from the wild-type. A method for selecting a variant or engineered i-onui endonuclease, i-onui endonuclease homologue, and a hybrid of two i-onui or i-onui homologue domains that have a target site altered from the wild-type and directed to a site within a gene of interest is also provided.
Surface display of cellulolytic enzymes and enzyme complexes on gram-positive microorganisms
In various embodiments a system is provided that displays heterologous proteins on the surface of a gram-positive microorganism. In certain embodiments the system displays proteins using a sortase transpeptidase to covalently anchor proteins to the cell wall of the microbe.
Three-dimensional (3d) porous electrode architecture for a microbattery
A three-dimensional porous electrode architecture for a microbattery includes a substrate having first and second conductive patterns disposed thereon where the first and second conductive patterns are electrically isolated from each other, a three-dimensional porous cathode disposed on the first conductive pattern, and a three-dimensional porous anode disposed on the second conductive pattern. The porous cathode includes a first conductive scaffold conformally coated with a layer of a cathode active material and having a porosity defined by a network of interconnected pores, where the first conductive scaffold has a lateral size and shape defined by the first conductive pattern and porous side walls oriented substantially perpendicular to the substrate.
Biodegradable supporting device
A biodegradable in vivo supporting device is disclosed. The in vivo supporting device comprises a biodegradable metal scaffold and a biodegradable polymer coating covering at least a portion of the biodegradable metal scaffold, wherein the biodegradable polymer coating has a degradation rate that is faster than the degradation rate of the biodegradable metal scaffold..
Artificial tissue constructs comprising alveolar cells and methods for using the same
The present invention comprises artificial tissue constructs that serve as in vitro models of mammalian lung tissue. The artificial tissue constructs of the present invention comprise functionally equivalent in vitro tissue scaffolds that enable immunophysiological function of the lung.
Compositions and methods for formation of bone tissue
Provided is a step-wise method of forming an engineered construct. Various embodiments include inducing differentiation of progenitor cells, such as embryonic stem cells; expanding the differentiated progenitor cells; combining the expanded progenitor cells and a biocompatible scaffold comprising a matrix material; and incubating the progenitor cells and the biocompatible scaffold so as to form a bone tissue module..
Self-contained, portable and self-supporting scaffolding kit
A self-contained portable self-supporting scaffolding kit for mounting adjacent an elevated structure and allowing a user to reach the elevated structure to work thereon. The kit includes a movable base assembly that supports a tower assembly along which a platform assembly moves, in a use configuration.
Temporary vascular scaffold and scoring device
Devices and methods for treating a target site in a body lumen are provided. A medical device includes a stent-like structure including a plurality of scoring and non-scoring filaments interwoven with one another.
The invention comprises a method of making molded, double-crosslinked (i.e., two stages of crosslinking), transparent, collagen materials using a novel combination of diafiltration, lyophilization, and homogenization. The collagen material can be used not only as an ophthalmic device, but also as a tissue scaffold, drug delivery device, wound dressing, or other collagen hydrogel based device..

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Scaffold topics: Nucleotide, Recombinant, Polynucleotide, Amino Acid, Biodegradable, Encapsulation, Surfactant, Enhancement, Monoclonal Antibody, Polypeptide, Immunogenic, Amino Acid Sequence, Monoclonal, Interleukin 2, Immune Disease

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This listing is a sample listing of patent applications related to Scaffold for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Scaffold with additional patents listed. Browse our RSS directory or Search for other possible listings.

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