Scaffold

Scaffold-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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NEW Enhanced strength spreader step for use with rope ladders
May 25, 2017 - N°20170145747

This invention relates to a spreader step for a rope ladder comprising a metal scaffold having three types of overlapping elements. There are two parallel elongate elements, two u-shaped elements, the ends of which are inserted into the ends of the parallel elongate elements, and four strengthening elements that are disposed over the other two types of elements at the ...
NEW Renewably derived thermoplastic polyester-based urethanes and methods of making and using the same
May 25, 2017 - N°20170145145

The disclosure generally provides high-molecular-weight thermoplastic polyester-based urethanes (tpeus). In some embodiments, the component monomers of the tpeus are entirely derived from renewable sources. The disclosure also provides methods of making high-molecular-weight tpeus, and, in particular, methods for achieving such high molecular weights. The disclosure also provides certain uses of such tpeus. Entirely lipid-derived segmented thermoplastic tpeu elastomers with rubber-like ...
NEW Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits
May 25, 2017 - N°20170144979

The present disclosure is directed to compositions and methods which utilize the tetracycline scaffold, preferably the scaffold of tetracycline or minocycline, and which significantly lack antibiotic activity. The compounds have neuroprotective attributes without interfering with the drugs capacity to pass through the blood brain barrier. These compounds have neuroprotective activity because of their inhibition of neuronal cell cycle progression. The ...
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NEW Implant surfaces
May 25, 2017 - N°20170143495

The implants of the invention relate to improved implants formed using additive manufacturing techniques, the implants including a hemispherical cup portion, and an ischium flange, a pubic ramus flange and an ilium flange, each flange extending outwardly from the perimeter of the hemispherical cup portion, wherein the implant surface includes an area of integrally formed three dimensional scaffold on the ...
Three-dimensional prefabricated flashing scaffolding system
Norwood Architecture, Inc.
May 18, 2017 - N°20170138113

A three dimensional scaffold formed of mesh, or semi-porous material is designed to be inserted into and to surround an opening in the exterior structure of a building to receive a fenestration product such as a door, a vent, a window and a skylight. The three dimensional scaffold is pre-formed into three-dimensional shapes that include corners, returns, back-dams, and optional ...
Polypeptide hydrogels and uses related thereto
Georgia Tech Research Corporation
May 18, 2017 - N°20170137785

This disclosure relates to self-assembling peptides that form hydrogels comprising peptide sequences for the activation of signaling pathways. In certain embodiments, the disclosure relates to compositions comprising a recombinant polypeptide comprising a cell signaling sequence, e. G., jag-1 sequence, fused to a hydrogel polypeptide sequence. In certain embodiments, the disclosure relates to methods of cell culture on three dimensional scaffolds/...
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Ordered nanoscale domains by infiltration of block copolymers
Uchicago Argonne, Llc
May 18, 2017 - N°20170137577

A method of preparing tunable inorganic patterned nanofeatures by infiltration of a block copolymer scaffold having a plurality of self-assembled periodic polymer microdomains. The method may be used sequential infiltration synthesis (sis), related to atomic layer deposition (ald). The method includes selecting a metal precursor that is configured to selectively react with the copolymer unit defining the microdomain but is ...
Remote-controlled vertical ascending and descending workstation
Uchicago Argonne, Llc
May 18, 2017 - N°20170137260

An apparatus designed for climbing poles, trees and other such columnar objects. The apparatus is a remote-controlled work station that provides a scaffold for mounting semi-robotic articulated arms and video cameras. The articulated arm has a quick-release coupler on an end thereof that is able to repeatedly and releasably couple attachments thereto, such as saws, blades, and other pruning objects. ...
Stepper scaffoldings putting mats
Uchicago Argonne, Llc
May 18, 2017 - N°20170136292

The present disclosure relates to improvement of the stepper scaffoldings attaching soft mats which supply users with soft touch, can make users exercise without putting on sneakers indoors, and can protect users' joints, waists, and ankles, moreover can make him or her get acupressure effects as well as the recovery from fatigue at the same time. This disclosure has a ...
Biodegradable scaffolds
Board Of Regents Of The University Of Texas System
May 18, 2017 - N°20170136154

In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) ...
Implantable cellular therapy device for treatment of graft versus host disease and tolerance induction
Viera Bioscience, Inc.
May 18, 2017 - N°20170136153

Implantable devices comprising a scaffold, cells, and/or therapeutic molecules are provided. Uses include inhibition of pathological immunity, elaboration of therapeutic growth factors, and immune augmentation. The implantable device may contain a porous substrate structure to which therapeutic cells are adherent, which can be implanted and explanted from a patient. In another embodiment, a medical device includes a porous substrate ...
Devices for effecting faster healing of orthopedic and other wounds
Viera Bioscience, Inc.
May 18, 2017 - N°20170136142

Disclosed are medical devices, e. G., surgical sutures, surgical staples, surgical pads, surgical meshes, surgical scaffolds etc., and methods of use at a wound in a patient to facilitate the rapid healing of the tissue at the situs of the wound with minimal fibrous tissue formation. The devices are arranged to be brought into engagement with tissue adjacent the wound ...
Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers
Immatics Biotechnologies Gmbh
May 18, 2017 - N°20170136108

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
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Novel diester and triester based low molecular weight, biodegradeable cationic lipids for oligonucleotide delivery
Sirna Therapeutics, Inc.
May 18, 2017 - N°20170135962

The instant invention provides for novel cationic lipids of formula a that can be used in combination with other lipid components such as cholesterol and peg-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower ...
Tissue-engineered constructs
Humacyte, Inc.
May 18, 2017 - N°20170135805

The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.
Methods and compositions for promoting the structural integrity of scaffolds for tissue engineering
Biostage, Inc.
May 18, 2017 - N°20170135796

Aspects of the disclosure relate to synthetic tissue or organ scaffolds and methods and compositions for promoting or maintaining their structural integrity. Aspects of the disclosure are useful to prevent scaffold damage (e. G., delamination) during or after implantation into a host. Aspects of the disclosure are useful to stabilize tissue or organ scaffolds that include electrospun fibers.
3-d in vitro model for breast cancer dormancy
New Jersey Institute Of Technology
May 11, 2017 - N°20170131273

Disclosed is a three-dimensional (3-d) in vitro model for studying and subsequently treating cancer dormancy. The model is specifically useful in studying breast cancer and may be used for drug discovery because it maintains the breast cancer cells in a dormant state, unlike conventional two-dimensional (2-d) tissue culture plastic (tcp). Tumor-forming breast cancers cells were seeded on the 3-d model ...
Scaffold and method
Werner Co.
May 11, 2017 - N°20170130470

A scaffold includes a first end frame assembly. The scaffold includes a second end frame assembly. The scaffold includes a first side brace assembly supported by the first end frame assembly and the second end frame assembly. The scaffold includes a second side brace assembly supported by the first end frame assembly and the second end frame assembly. Each end ...
Scaffold bracket
Apache Industrial Services
May 11, 2017 - N°20170130469

Various implementations described herein are directed to a scaffold bracket. In one implementation, the scaffold bracket may include a mounting bracket having a first face and a second face opposite of the first face. The scaffold bracket may also include a first scaffolding node attached to the first face and configured to couple to a first member. The scaffold bracket ...
Method for culturing and patterning cells
President And Fellows Of Harvard College
May 11, 2017 - N°20170130196

A cell scaffold includes a string having a diameter of less than 500 μm; a hydrogel matrix supported on the string; and cells seeded onto the hydrogel matrix. The scaffold is used to cultivate cells, and to evaluate cell viability or cell metabolic activity.
Guiding stem cell differentiation using graphene-nanofiber hybrid scaffolds
Rutgers, The State University Of New Jersey
May 11, 2017 - N°20170130194

The present invention relates to graphene oxide-coated nanofiber scaffold that provides instructive physical cues to the differentiation of stem cells into selected cell lineages or networks.