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Roti patents

      

This page is updated frequently with new Roti-related patent applications.




Date/App# patent app List of recent Roti-related patents
08/18/16
20160237059 
 Heterocyclic substituted trifluoromethyl pyrimidinones and their use patent thumbnailHeterocyclic substituted trifluoromethyl pyrimidinones and their use
The present application relates to novel heterocyclically substituted 6-(trifluoromethyl)pyrimidin-4(3h)-one derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular, renal, inflammatory and fibrotic diseases.. .
Bayer Pharma Aktiengesellschaft


08/18/16
20160235891 
 Mineralized collagen-based femoral head support device patent thumbnailMineralized collagen-based femoral head support device
A femoral head support device, in particular a mineralized collagen-based femoral head support device applicable to the treatment of early osteonecrosis of femoral head. The device is made from a dense, homogeneous organic/inorganic composite, wherein the organic phase includes collagen and inorganic phase includes nano calcium phosphate salt, and the device is of a cylinder having an upright through hole and also has a support strength of up to 4000-6000n.

08/18/16
20160235672 
 Reconstituted high density lipoproteins composition and uses thereof patent thumbnailReconstituted high density lipoproteins composition and uses thereof
A reconstituted high density lipoprotein composition including negatively charged phospholipids enhances cholesterol clearance, reduces inflammation and other anti-atherosclerotic actions.. .
Universite Pierre Et Marie Curie - Paris 6 (upmc)


08/11/16
20160228599 
 System and  delivery of a protease inhibitor patent thumbnailSystem and delivery of a protease inhibitor
The disclosed invention provides a system and method of artificially retarding fibrin-based blood clot degradation via the sustained release of a protease inhibitor, such as, for example, aprotinin or tranexamic acid (“ta”). The sustained release of the protease inhibitor is accomplished through incorporation within a biodegradable polymer microsphere to produce a protease inhibitor formulation.
Bordoloi Biotech, Llc


08/11/16
20160228403 
 Agent for preventing or ameliorating renal dysfunction patent thumbnailAgent for preventing or ameliorating renal dysfunction
An object of the present invention is to provide an agent for preventing or ameliorating renal dysfunction, excellent in the inhibitory action on the advance of renal dysfunction, the suppressive action on renal fibrosis, the suppressive action on the development of renal failure, and the suppressive action on nephritis. The administration of an agent for preventing or ameliorating renal dysfunction, containing lubiprostone or its pharmacologically acceptable salt as an active ingredient by a method, such as oral administration, can inhibit the advance of renal dysfunction, suppress renal fibrosis, suppress the development of renal failure, and suppress nephritis, and thus can prevent or ameliorate nephritides, such as acute glomerulonephritis, minimal change nephritis, chronic glomerulonephritis, renal sclerosis, membrane proliferative nephritis, mesangial proliferative glomerulonephritis, membrane proliferative glomerulonephritis, crescentic nephritis, rapidly progressive glomerulonephritis, membranous glomerulonephritis, tubulointerstitial nephritis, acute pyelonephritis, chronic pyelonephritis, endocapillary proliferative nephritis, and lupus nephritis; renal failures, such as acute renal failure and chronic renal failure; and renal dysfunctions, such as amyloid kidney, membranous nephropathy, focal glomerulosclerosis, iga nephropathy, acute tubular necrosis, nephrotic syndrome, diabetic nephropathy, gouty kidney, renal edema, renal tumors, renal ischemic disorders, and renal ischemia-reperfusion injury..
Tohoku University


08/04/16
20160222097 
 Prevention of tissue ischemia and related methods patent thumbnailPrevention of tissue ischemia and related methods
Provided herein are compositions for preventing, ameliorating, and/or reducing tissue ischemia and/or tissue damage due to ischemia, increasing blood vessel diameter, blood flow and tissue perfusion in the presence of vascular disease including peripheral vascular disease, atherosclerotic vascular disease, coronary artery disease, stroke and influencing other conditions, by suppressing cd47 and/or blocking tsp1 and/or cd47 activity or interaction. Influencing the interaction of cd47-tsp1 in blood vessels allows for control of blood vessel diameter and blood flow, and permits modification of blood pressure and cardiac function.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv


08/04/16
20160221965 
 Disubstituted trifluoromethyl pyrimidinones and their use patent thumbnailDisubstituted trifluoromethyl pyrimidinones and their use
The present application relates to novel 2,5-disubstituted 6-(trifluoromethyl)pyrimidin-4(3h)-one derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular, renal, inflammatory and fibrotic diseases.. .
Bayer Pharma Aktiengesellschaft


08/04/16
20160220258 
 Method for setting elastic threads in ligation device and automatic elastic thread ligation device patent thumbnailMethod for setting elastic threads in ligation device and automatic elastic thread ligation device
The present invention provides a method for setting elastic threads in a ligation device and an automatic elastic thread ligation device using the method. At least one elastic thread (2) is arranged along the outer wall of a barrel (3) of the ligation device, and an annular sleeve (21) with an adjustable aperture and formed at the front end of the elastic thread (2) is sleeved on the outer wall of the front end of the barrel; a traction thread (26) on the ligation device is connected with the annular sleeve (21) of the elastic thread (2), and when the traction thread (26) is pulled, the traction thread drives the annular sleeve (21) to move towards the orifice of the barrel (3), until the annular sleeve is disengaged from the orifice; a force bearing part of the annular sleeve (21) at the front end of the elastic thread is propped forwards, meanwhile, the tail end of the elastic thread (2) is pulled backwards, and the countertraction between the two acting forces leads to a gradual decrease of the aperture of the annular sleeve (21) at the front end of the elastic thread (2).

07/28/16
20160214986 
 Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders patent thumbnailNovel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
Wherein r1a, r1b, r2, r4, r5, r6, r7, r8, w, x, y, z, cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (npp2 or enpp2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, and/or abnormal angiogenesis associated diseases by administering the compound of the invention..

07/28/16
20160213760 
 Aprotinin-derived polypeptide-antibody conjugates patent thumbnailAprotinin-derived polypeptide-antibody conjugates
The present invention relates to protein conjugates comprising an aprotinin-derived polypeptide, which facilitates transport of the conjugate across the blood-brain barrier, and an antibody moiety that selectively binds a target within the cns. The protein conjugates are further defined by the inclusion of a linker; by the number of polypeptides conjugated to each antibody moiety; by the positions at which the antibody moiety and the polypeptides are conjugated; and by the larger configuration of the conjugate (in which every polypeptide is linked only to the antibody moiety).
Angiochem Inc.


07/28/16
20160213755 

Feed additive composition


A method for improving the performance of a subject or for improving digestibility of a raw material in a feed (e.g. Nutrient digestibility, such as amino acid digestibility), or for improving nitrogen retention, or for improving dietary phosphorus absorption and retention, or for improving the efficacy of the phytase, or for improving the subject's resistance to necrotic enteritis or for improving feed conversion ratio (fcr) or for improving weight gain in a subject or for improving feed efficiency in a subject or for modulating (e.g.
Dupont Nutrition Biosciences Aps


07/28/16
20160213381 

Devices and techniques for vascular compression


The present disclosure provides for specific shapes and combinations of the compression members amenable to the safest, yet most effective compression of the carotid and vertebral arteries aimed at prevention of embolic stroke. An associated method of achieving an optimal compression of said arteries for the purpose of stroke prevention is provided..

07/21/16
20160208013 

Methods and compositions for reducing cardiac damage and other conditions


Endoglin has been identified to play a functional role as a regulator of tgfβ1 signaling, particular in tgfβ1-mediated calcineurin expression. The present invention features methods of reducing cardiac damage, particularly in a subject undergoing chemotherapy or radiation therapy by administering a composition that inhibits endoglin activity.
Tufts Medical Center, Inc.


07/21/16
20160206709 

Antimicrobial composition comprising pyrogenic silica and serrathopeptidase and uses thereof


Methods are provided for treatment of wounds using a complex antimicrobial sorption composition possessing the necrolytic effect for treating the purulent wounds, the trophic ulcers, the wounds, and the infiltrates with the significant necrotic and exudative components represents the silica sorbent with the immobilized drug. Pyrogenic silica is used as a siliceous sorbent, and serrathiopeptidase as a drug..
Willingsford Limited


07/21/16
20160206591 

Treatments for fibrotic diseases


Disclosed herein are methods for treatment for fibrosis, ocular pathologies associated with fibrosis, including proliferative vitreoretinopathy (pvr) by inhibiting the activity of activated transforming growth factor β activated kinase 1 (tak1), or activation thereof. Pharmaceutical compositions for use in the described treatments are also provided..
Mor Research Applications Ltd.


07/14/16
20160202239 

Blood based biomarkers for diagnosing atherosclerotic coronary artery disease


The invention, in some aspects, relates to methods for evaluating a human subject for having atherosclerotic coronary artery disease (ascad) or as having a coronary atherosclerotic plaque. In some aspects, the invention relates to methods and kits useful for diagnosing, classifying, profiling and treating atherosclerotic cad and or a coronary atherosclerotic plaque..
Global Genomics Group, Llc


07/14/16
20160200796 

Fusion protein comprising albumin and retinol-binding protein


There is provided a fusion protein comprising albumin and retinol-binding protein (rbp), which can be used for preventing or treating fibrotic diseases. The fusion protein, in which albumin and rbp are bound together, is incorporated into stellate cells and induces phenotypic reversion from myofibroblast-like cells to quiescent fat-storing phenotype.
Korea University Research And Business Foundation


07/14/16
20160199316 

Three-layer transdermal therapy system (tts)


The invention relates to an at least three-layer transdermal therapy system (tts), which contains, in particular, rotigotine as an active ingredient. The tts comprises an active ingredient-containing central layer, which comprises at least one hygroscopic polymer or copolymer, an inner, active ingredient-permeable layer and an outer layer..
Tesa Labtec Gmbh


07/14/16
20160199127 

Methods and apparatuses for treating auto-immune diseases by ablative neuromodulation


The present invention, in some embodiments thereof, relates to intravascular neural ablation and, more particularly, but not exclusively, to tools and methodologies for treating systemic nerve hyperactivity through splenic and/or carotid denervation. Devices are disclosed for performing ablation and protecting a patient from formation of embolisms.
La Vita Technologies Ltd.


07/14/16
20160199091 

Intravascular catheter balloon device having a tool for atherectomy or an incising portion for atheromatous plaque scoring


An apparatus and method is disclosed for an intravascular balloon device having a balloon and a handle where a catheter tube extends between the two. The handle assembly includes an inflation device in fluid communication with the balloon.

07/14/16
20160199072 

Bone removal under direct visualization


An approach to removing necrotic bone under direct visualization is provided. To remove bone and to watch it being removed at the same time, one example uses an endoscope and bone removal tool assembled together by a sheath.
Smith & Nephew, Inc.


07/07/16
20160194406 

Modulation of efferocytosis pathways for treatment of atherosclerotic disease


Smooth muscle cells (smc) from subjects carrying at least one 9p21 risk factor, can be resistant to efferocytosis, leading to the retention of such cells in the necrotic core of atherosclerotic plaque. In the methods of the invention, an agent that increases efferocytosis of cellular components of coronary plaque, including efferocytosis of apoptotic smooth muscle cells, is administered to the subject in a dose and for a period of time effective to stabilize, prevent or reduce atherosclerotic plaque in the individual..
The Board Of Trustees Of The Leland Stanford Junior University


07/07/16
20160193206 

Bet-protein-inhibiting dihydropyridopyrazinones


This invention further relates to the use of bet protein inhibitors in viral infections, in neurodegenerative disorders, in inflammation diseases, in atherosclerotic disorders and in male fertility control.. .

06/30/16
20160185737 

N-alkoxyamide conjugates as imaging agents


The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided.

06/30/16
20160184393 

Treatment of x-linked hypohidrotic ectodermal dysplasia with a fusion eda1 protein


The invention relates to methods for the temporal administration of eda agonists, in particular edi200, which correlate to optimal therapeutic response windows required for the formation of any eda-dependent structures such as ectodermal appendages. Use of the methods described allow for the design of targeted therapeutic dosing and administration regimens in order to correct or alter abnormal phenotypes associated with genetic disorders, in particular, xlhed..

06/23/16
20160176867 

Modified bet-protein-inhibiting dihydroquinoxalinones and dihydropyridopyrazinones


This invention further relates to the use of bet protein inhibitors in viral infections, in neurodegenerative disorders, in inflammation diseases, in atherosclerotic disorders and in male fertility control.. .

06/16/16
20160168128 

Inhibitors of cellular necrosis and related methods


Or a pharmaceutically acceptable salt, prodrug, stereoisomer or tautomer thereof, is provided. Related compounds, methods for preparation of the same and uses of the compounds for treatment of various indications, including treatment of necrotic cell diseases and/or inflammation, are also provided..

06/16/16
20160166804 

Transcarotid neurovascular catheter


An interventional catheter for treating an artery includes an elongated body sized and shaped to be transcervically introduced into a common carotid artery at an access location in the neck. The elongated body has an overall length such that the distal most section can be positioned in an intracranial artery and at least a portion of the proximal most section is positioned in the common carotid artery during use..
Silk Road Medical, Inc.


06/16/16
20160166684 

Treatment of fibrotic diseases


The present invention relates to rspo and lgr antagonists, and methods of using the rspo and lgr antagonists for treating or preventing fibrotic diseases.. .
Oncomed Pharmaceuticals, Inc.


06/09/16
20160158502 

Methods and devices for transcarotid access


Disclosed is an arterial access sheath for introducing an interventional device into an artery. The arterial access sheath includes an elongated body sized and shaped to be transcervically introduced into a common carotid artery at an access location in the neck and an internal lumen in the elongated body having a proximal opening in a proximal region of the elongated body and a distal opening in a distal region of the elongated body.
Silk Road Medical, Inc.


06/09/16
20160158044 

Systems and methods for treating a carotid artery


Systems and methods are adapted for treating the carotid artery. The systems include interventional catheters and blood vessel access devices that are adapted for transcervical insertion into the carotid artery.
Silk Road Medical, Inc.


06/09/16
20160157826 

Non-imaging two dimensional array probe and system for automated screening of carotid stenosis


A non-imaging diagnostic ultrasound system for carotid artery diagnosis has a two dimensional array probe (10) with a low element count and relatively large element size which can cover an area of the carotid artery at its bifurcation. The elements are operated independently with no phasing, and detect doppler flow spatially beneath each element.
Koninklijke Philips N.v.


06/09/16
20160157814 

Non-imaging two dimensional array probe and system for classifying carotid stenosis


A non-imaging diagnostic ultrasound system for carotid artery diagnosis has a two dimensional array probe with a low element count and relatively large element size which can cover an area of the carotid artery at its bifurcation. The elements are operated independently with no phasing, and detect doppler flow spatially beneath each element.
Koninklijke Philips N.v.


06/02/16
20160152999 

Rhizomania-resistant gene


The present invention provides a new nucleic acid molecule which encodes a polypeptide that is able to convey a resistance to a pathogen, in particular to “beet necrotic yellow vein virus” in a plant, in particular a plant of the beta genus, in which the polypeptide is expressed, and also a preferred nucleic acid molecule encoding the rz-3 gene of beta maritima, derivatives and homologues thereof. Further aspects of the invention include vectors, transgenic plant cells, transgenic plants, methods for production thereof, and methods for identifying a resistance-conveying nucleic acid molecule..
Kws Saat Se


05/26/16
20160145294 

Antagonists of cb1 receptor


The invention relates to an antagonist of cb1 receptor for use in the treatment of a pathologic condition or disorder selected from the group consisting of bladder and gastrointestinal disorders; inflammatory diseases; cardiovascular diseases; nephropathies; glaucoma; spasticity; cancer; osteoporosis; metabolic disorders; obesity; addiction, dependence, abuse and relapse related disorders; psychiatric and neurological disorders; neurodegenerative disorders; autoimmune hepatitis and encephalitis; pain; reproductive disorders and skin inflammatory and fibrotic diseases.. .
Universite De Bordeaux


05/26/16
20160145177 

Method for purifying 2-fluorobutane


The present invention is a method for 2-fluorobutane to obtain highly purified 2-fluorobutane through a process comprising a step for: bringing crude 2-fluorobutane that includes 5 to 50 wt % of butene into contact with a brominating agent that can form a bromonium ion in an aprotic polar solvent in the presence of water or an alcohol having up to 4 carbon atoms; converting the butene into compounds having a boiling point higher than that of 2-fluorobutane, then recovering 2-fluorbutane from the reaction solution; and purifying the recovered 2-fluorabutane by distillation.. .
Zeon Corporation


05/26/16
20160143561 

Self-contained, portable h2/co2 (air) ratio apparatus


A self-contained, portable h2/co2 (air) ratio apparatus has an exhaled breath system, an air analyzing chamber, a hydrogen concentration analyzer, a carbon dioxide (air) concentration analyzer, an air outlet, a computational analyzer and a display unit. The display unit can be a part of the self-contained, portable h2/co2 (air) ratio apparatus, remotely a part of the self-contained, portable h2/co2 (air) ratio apparatus, or combinations thereof.
Ony, Inc.


05/19/16
20160139051 

Apparatus and distinguishing between different tissue types using specific raman spectral regions


A portable apparatus and method for distinguishing between different tissue types, such as normal tissue, necrotic tissue, and tumor tissue are provided, where the apparatus includes a housing and a plurality of raman spectrometers disposed within the housing, each spectrometer having a different spectral region. A processor is provided in communication with the plurality of spectrometers, the processor analyzing output from the plurality of spectrometers to identify the tissue type of the tissue sample.
Wayne State University


05/19/16
20160137719 

Process for producing high purity fibrinogen and thrombin for fibrin sealant


The present invention relates to a fibrin sealant kit comprising purified fibrinogen and thrombin. The invention particularly relates to an improved chromatographic process for the purification of thrombin and fibrinogen components devoid of any significant plasminogen and other impurities.
Hemarus Therapeutics Limited


05/19/16
20160136133 

Medicaments for the treatment or prevention of fibrotic diseases


R1 to r5 and x are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.. .

05/19/16
20160136107 

Storage stable transdermal patch of rotigotine


Disclosed is a transdermal delivery device comprising a backing layer, a release liner, and an adhesive layer between the backing layer and the release liner, the adhesive layer comprising an active agent solubilized in an adhesive matrix, the adhesive matrix comprising a mixture of biocompatible polymers, wherein the active agent is soluble in at least one of the biocompatible polymers.. .
Mylan Technologies, Inc.


05/19/16
20160136001 

Sock for treatment of foot and leg wounds, methods of use and manufacture


The improved sock is made of yarns knitted into a foot and calf, with graduated compression on an individual's foot from the foot to the calf. The yarns can include wool and alpaca fibers.
Vive Wear Llc


05/19/16
20160135720 

Optical capsule and spectroscopic treating and diagnosing the intestinal tract


A device and method for mapping, diagnosing and treating disorders or other diseases, disorders or conditions (e.g., bleeding, ischemic or necrotic tissue, and presence of certain chemicals or substances) of the intestinal tract is provided using a capsule passing through the intestinal tract and sensing optical characteristics as the capsule passes through. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed.
Entrack, Inc.


05/12/16
20160129011 

Bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines


Pharmaceutical compositions comprising the compounds according to the invention, and the prophylactic and therapeutic use thereof for hyperproliferative disorders, especially for tumour disorders, are described. Furthermore, the use of bet protein inhibitors in benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, in neurodegenerative disorders, in inflammatory disorders, in atherosclerotic disorders and in male fertility control is described..

05/05/16
20160122433 

Anti-pdgfr-beta antibodies and uses thereof


The present invention provides antibodies that bind to platelet derived growth factor receptor beta (pdgfr-beta) and methods of using the same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human pdgfr-beta with high affinity.
Regeneron Pharmaceuticals, Inc.


05/05/16
20160120950 

Pharmaceutical formulations comprising incretin mimetic peptide and aprotic polar solvent


The present disclosure is directed to stable pharmaceutical formulations and uses thereof.. .
Astrazeneca Pharmaceuticals Lp


05/05/16
20160120822 

Composition containing rotigotine and use thereof and transdermal patch containing the composition


A rotigotine-containing composition having a matrix mixture system formed from a polyvinylpyrrolidone and a combination of an acrylic pressure-sensitive adhesive with a silicone pressure-sensitive adhesive. The polyvinylpyrrolidone may be present in an amount of about 1-10% by weight in the matrix mixture system.
Jiangsu Kangbeide Pharmaceuticals Co. Ltd.


05/05/16
20160120509 

Hypodermic needle with enhanced ultrasound signature for carotid artery stenting


A hypodermic needle outer surface deflects ultrasound signals hitting the surface. The reflected signals depend on the surface which the ultrasound signal hits.

04/28/16
20160115246 

Methods for inhibiting atherosclerosis by administering an inhibitor of pcsk9


The present invention provides methods and compositions for inhibiting atherosclerotic plaque formation in a subject. In certain embodiments, the methods of the present invention comprise selecting a subject who has, or is at risk of developing, atherosclerosis, and administering to the subject a pharmaceutical composition comprising a proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitor.
Regeneron Pharmaceuticals, Inc.


04/28/16
20160113968 

Hypoxia-cultured mesenchymal stem cells for treating atherosclerotic lesions


A method and a pharmaceutical composition for treating an atherosclerotic lesion are provided, including administering a subject in need thereof a therapeutically effective amount of a composition comprising hypoxia-cultured mscs obtained by culturing auto- or allo-mscs under low oxygen conditions.. .
National Yang-ming University


04/28/16
20160113675 

Intravascular catheter having a cantilevered expandable incising portion


An intravascular device is provided having a catheter tube and an expandable portion including a plurality of struts supported in a cantilevered fashion so as to be splayed open when in an opened position. An incising element is provided on at least one of the struts and has a sharpened edge for creating an incision in atherosclerotic material located within a blood vessel when the expandable portion is in the opened position..

04/21/16
20160106851 

Groundbreaking platform technology for specific binding to necrotic cells


A system comprising a targeting molecule for binding necrotic cells; to the system for use as a medicament; to use of the system for diagnosis; to the system for use in treatment of diseases involving necrotic cell death, to a dosage comprising the system; to a method for determining localization of the composition within a sample using said system; and, to a method for treatment of cancers and/or diseases involving necrotic cell death using said system. In particular the invention relates to compositions targeting necrotic cells..

04/21/16
20160106811 

Method for repairing neurodegeneration


The present invention provides for treating neurodegeneration caused by nerve compression syndrome or entrapment neuropathy comprising administering human acidic fibroblast growth factor (afgf), fibrinogen, aprotinin and divalent calcium ions to a subject in need thereof.. .

04/14/16
20160101165 

Compositions and kits for enzymatic debridement and methods of using the same


A debridement enzyme for necrotic tissue is described that is not dependent upon proteolytic enzymatic activity but instead utilizes the amylase family of enzymes. The amylases (α-, β-, γ-amylase) are noted for the cleavage of the α-glycosidic bonds of polysaccharides, yielding lower molecular weight carbohydrate/sugar fragments.

04/14/16
20160100879 

Electrical ablation devices and methods


A computer-implemented system for delivering energy to tissue having a necrotic threshold may generally comprise an electrode array comprising a plurality of electrodes, a central electrode positioned intermediate the plurality of electrodes, and a controller configured to not only apply a first sequence of electrical pulses to the electrode array to induce thermal heating in the tissue and reduce the necrotic threshold of the tissue but also apply a second sequence of electrical pulses to the central electrode to induce cell necrosis in the tissue by irreversible electroporation. Electrical ablation devices and methods of using the same are also described herein..

04/07/16
20160095876 

Composition and kits for inhibition of pathogenic microbial infection and methods of using the same


Antimicrobial polymer coating formulations are prepared that protect biological surfaces by treating, reducing, ameliorating, preventing or inhibiting pathogenic microorganism ingress to a human or animal host, reducing the potential for infection, particularly by necrotizing fasciitis originating microorganisms, through use of an polymer coating barrier containing antimicrobial agents that facilitates sustained release of biocidal agents active against such opportunistic microorganisms. Such formulations are effective for inhibiting microbial ingress pertaining to soft tissue and skin tears, abrasions, punctures and surgical wounds, and can be used as in water environments and as a skin protectant sunscreen and insect repellent..
Rochal Industries, Llp


03/31/16
20160089252 

Extravascular protective stent


An extravascular protective stent includes a booster, a hollow protective tube and a hollow separator all sequentially arranged, wherein the side wall of the protective tube is provided with a protective notch parallel to the central axis of the protective tube and extending through two ends of the protective tube. During use of the separator and the protective tube when an internal carotid artery is exposed after a common carotid artery bifurcation is separated via a submandibular incision, the separator and the protective tube wrap the internal carotid artery in sequence, allowing the separating notch and the protective notch to face outward, and the closed wall thereof to face inward and directly face the surgery direction, such that a surgeon can thoroughly excise diseased tissue in surgery and avoid hemorrhage caused by accidentally injuring the internal carotid artery during the surgery, and improve the surgical efficacy..

03/24/16
20160082264 

Implantable device including a stimulation lead for bioimpedance measurement


An implantable device includes a lead, for example for neurostimulation of the vagus nerve. The lead includes a series of stimulation electrodes and a series of external electrodes for bioimpedance measurements on blood flow located in the same region, for example on the carotid artery.
Sorin Crm Sas


03/24/16
20160082051 

Use of sea cucumber glycosaminoglycan in preparing medicine for prevention and treatment of thromboembolic disease


The present invention discloses use of sea cucumber glycosaminoglycan in the preparation of drugs. In particular, the present invention relates to use of medical use of sea cucumber glycosaminoglycan, and more particularly to use of depolymerized sea cucumber glycosaminoglycan or natural molecular segments of sea cucumber glycosaminoglycan with a weight average molecular weight greater than 54,500 da in the preparation of a drug for the prevention and treatment of thromboembolic diseases.
Heilongjiang Hongdoushan Pharmaceutical Co., Ltd.


03/24/16
20160082011 

Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome


The present invention relates to methods for treating and/or preventing podocytes related disorders and/or nephrotic syndrome comprising the administration of an effective amount of a certain dpp-4 inhibitor, as well as to the use of a certain dpp-4 inhibitor for treating and/or preventing a metabolic disease in a patient with or at risk of podocytes related disorders and/or nephrotic syndrome.. .
Boehringer Ingelheim International Gmbh


03/24/16
20160081848 

Cooling elements with bands


A kit for cooling the blood in the carotid arteries includes a cervical immobilization collar and a cooling element. The cooling element may include a body-facing panel attached on a body-facing surface to a lining layer, an outward-facing panel, and cooling material disposed between the body-facing panel and the outward facing panel.
Cryothemic Systems, Inc.


03/24/16
20160081643 

X-ray ct device and processing method


The present invention is capable of distinguishing four types or more of substances such as air, water (soft tissues), contrast medium, and bones (calcification) to diagnose progress of atherosclerotic sites using dual energy imaging. A subject is imaged with two types of different tube voltages and an image obtained by image reconstruction is binarized to carry out a reprojection process; thereby, the distance of penetration of air is estimated, the contribution of air in measurement projection data is determined, and the amount of reduction by the air is deducted from the projection data so as to enable distinction between four or more substances such as air, water (soft tissues), contrast medium, and bones (calcification)..
Hitachi Medical Corporation


03/24/16
20160081561 

Noninvasive arterial condition detecting method, system, and non-transitory computer readable storage medium


A noninvasive arterial condition detecting system includes a processing device and an electronic stethoscope configured for auscultating carotid artery to receive sound signals. The processing device is connected to the electronic stethoscope.
National Central University


03/17/16
20160074677 

Methods and devices to modulate the autonomic nervous system via the carotid body or carotid sinus


In some embodiments, sympathetic nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some embodiments, different types of energy sources are utilized singly or combined with one another.
Kona Medical, Inc.


03/17/16
20160074473 

Effect of phospholipid composition of reconstituted hdl on its cholesterol efflux and anti-inflammatory properties


The present invention relates to peptide-phospholipid formulations, methods of generating these formulations and methods of administering these formulations for treatment. The present disclosure also provides methods for increasing cholesterol efflux, inducing anti-atherosclerotic activity, increasing pre-β hdl, inducing anti-inflammatory activity, inhibiting cytokine release (including cytokines tnf-α, il-1β, and/or il-6 or a combination thereof) and increasing cholesterol mobilization and/or esterification by administering the peptide-phospholipid formulations disclosed..
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv


03/17/16
20160074466 

Angiotensins for treatment of fibrosis


The present invention provides, among other things, methods and compositions for treating or preventing fibrotic diseases, disorders or conditions based on angiotensin (1-7) polypeptides, and analogs or derivatives thereof. In some embodiments, compositions and methods for treating or preventing pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease (copd), asthma, cystic fibrosis, kidney fibrosis, liver fibrosis, systemic sclerosis, post-surgical adhesions, accelerating wound healing, and reducing or preventing scar formation are provided..
Tarix Pharmaceuticals Ltd.


03/17/16
20160074457 

Composition from sphaeranthus indicus and garcinia mangostana for the control of metabolic syndrome


Pharmaceutical/dietary supplements and food ingredient(s) derived from sphaeranthus indicus are used for controlling or treating a metabolic disorder. The supplements and food ingredient(s) are selected from sphaeranthus indicus extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof and their compositions, preferably in combination with at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from garcinia mangostana.
Laila Nutraceuticals


03/17/16
20160074422 

Mucus strengthening formulations to alter mucus barrier properties


The present technology relates to compositions and methods that strengthen mucus barriers, e.g., reduce the permeability of the mucus barriers. In some embodiments, the compositions include a model bile and a lipid mixture, wherein the model bile includes at least one salt and a lecithin.
Northeastern University


03/10/16
20160069868 

Molecular targets and compounds, and methods to identify the same, useful in the treatment of fibrosis


The present invention relates to methods and assays for identifying agents useful in the treatment of fibrotic diseases, in particular diseases related to fibroblast migration and differentiation. The invention provides polypeptide and nucleic acid targets, sirna sequences based on these targets and antibodies against the targets.
Galapagos Nv


03/10/16
20160068487 

Novel compounds as diacylglycerol acyltransferase inhibitors


This invention relates to novel compounds which are inhibitors of acyl coenzyme a: diacylglycerol acyltransferase 1 (dgat-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination with weight management therapies or other triglyceride lowering therapy for the prevention or treatment of diseases related to dgat-1 dysfunction or where modulation of dgat-1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, genetic (type 1, type 5 hyperlipidemia) and acquired forms of hypertriglyceridemia or hyperlipoproteinemia-related disorders, caused by but not limited to lipodystrophy, hypothyroidism, medications (beta blockers, thiazides, estrogen, glucocorticoids, transplant) and other factors (pregnancy, alcohol intake), hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, cardiovascular outcomes, angina, excess hair growth (including syndromes associated with hirsutism), nephrotic syndrome, fibrosis such as mycocardial, renal and liver fibrosis, hepatitis c virus infection and acne or other skin disorders.. .
Glaxosmithkline Llc


03/10/16
20160068467 

Amphiphilic macromolecules and methods of use thereof


Or a salt thereof, wherein a, x, y, z and r1 have any of the values defined in the specification, and methods of use thereof. For example, certain embodiments of the invention provide a method for inhibiting atherosclerosis or atherosclerotic development in a mammal, comprising administering to the mammal an effective amount of a compound of formula (i), or a pharmaceutically acceptable salt thereof..

03/10/16
20160067247 

Novel use


The present invention is directed to compounds or pharmaceutically acceptable salts thereof for use in the treatment of fibrotic diseases such as idiopathic pulmonary fibrosis (ipf).. .
Glaxosmithkline Intellectual Property (no.2) Limited






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