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Roti-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Naphthyridine derivatives as alpha v beta 6 integrin antagonists for the treatment of e.g. fibrotic ...
October 12, 2017 - N°20170291899

Wherein r1 represents a five-membered aromatic heterocycle selected from a n- or a c-linked mono- or di-substituted pyrazole, an n- or a c-linked optionally mono- or di-substituted triazole or an n- or a c-linked optionally mono- or di-substituted imidazole, which five-membered aromatic heterocycle may be substituted by one or two of the groups selected a methyl group, an ethyl group, ...
Methods of treatment of cholestasis and fibrosis
Genfit
October 12, 2017 - N°20170290814

The present invention relates compounds useful and their use for treating cholestatic and fibrotic diseases.
Methods of treatment for cholestatic and fibrotic diseases
Genfit
October 12, 2017 - N°20170290813

The present invention relates to a synergistic combination of active ingredients for use in the treatment of fibrotic diseases.
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Topical application of ivermectin for the treatment of dermatological conditions/afflictions
Galderma S.a.
October 05, 2017 - N°20170281664

Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected skin area of an individual in need of such treatment, a topical pharmaceutical composition which comprises a thus effective amount of ivermectin.
Topical application of ivermectin for the treatment of dermatological conditions/afflictions
Galderma S.a.
October 05, 2017 - N°20170281663

Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected skin area of an individual in need of such treatment, a topical pharmaceutical composition which comprises a thus effective amount of ivermectin.
Methods and systems for treatment of acute ischemic stroke
Route 92 Medical, Inc.
October 05, 2017 - N°20170281204

A system of devices for treating an artery includes an arterial access sheath adapted to introduce an interventional catheter into an artery and an elongated dilator positionable within the internal lumen of the sheath body. The system also includes a catheter formed of an elongated catheter body sized and shaped to be introduced via a carotid artery access site into ...
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Methods and systems for treatment of acute ischemic stroke
Route 92 Medical, Inc.
September 28, 2017 - N°20170274180

A system of devices for treating an artery includes an arterial access sheath adapted to introduce an interventional catheter into an artery and an elongated dilator positionable within the internal lumen of the sheath body. The system also includes a catheter formed of an elongated catheter body sized and shaped to be introduced via a carotid artery access site into ...
Therapeutic and research application of pdcl3
Trustees Of Boston University
September 28, 2017 - N°20170274075

Described herein are novel compositions comprising, for example, pdcl3 polypeptides having vegfr-2 inhibitory activity, inhibitory pdcl3 antibodies and pdcl3-binding fragments thereof, or pdcl3 inhibitory nucleic acid molecules, and methods of their use in anti-angiogenesis and anti-tumor proliferation and invasiveness therapies, such as the treatment of cancer, as well as the treatment of those vascular diseases where pathological angiogenesis plays ...
Fusion protein comprising albumin and retinol-binding protein
Korea University Research And Business Foundation
September 28, 2017 - N°20170274044

There is provided a fusion protein comprising albumin and retinol-binding protein (rbp), which can be used for preventing or treating fibrotic diseases. The fusion protein, in which albumin and rbp are bound together, is incorporated into stellate cells and induces phenotypic reversion from myofibroblast-like cells to quiescent fat-storing phenotype. Therefore, the fusion protein can be effectively used in preventing or ...
Negative hydrogen ion intellegrnt filtration system for curing cancer, cardiovascular disease, diabetes, hypertension, nephrotic syndrome, ...
Mega Sun Biomedical Corp.
September 21, 2017 - N°20170267563

A negative hydrogen ion intelligent filtration system includes a housing; a filtering mechanism disposed in the housing and comprising a first filter, a second filter connected to the first filter, a third filter connected to second filter, a fourth filter connected to the third filter, a fifth filter connected to the fourth filter, a sixth filter connected to the fifth ...
Antioxidant compound having anti atherosclerotic effect and preparation thereof
Council Of Scientific And Industrial Research
August 24, 2017 - N°20170240577

The present invention relates to an antioxidant compound having anti atherosclerotic effect and preparation thereof. The present invention more particularly relates to the synthesis of tpp+ coupled esculetin (mitochondria-targeted esculetin [mito-esc]) followed by the biological evaluation of mito-esc for its ability to attenuate angiotensin-ii-induced atherosclerosis in apolipoproteine knockout (apoe−/− mice along with the endothelial cell age-delaying effects of ...
Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, ...
Los Angeles Biomedical Research Institute At Harbor- Ucla Medical Center
August 24, 2017 - N°20170239257

The present methods and compositions are of use for treatment of conditions involving fibrosis, such as peyronie's disease plaque, penile corporal fibrosis, penile veno-occlusive dysfunction, dupuytren's disease nodules, vaginal fibrosis, clitoral fibrosis, female sexual arousal disorder, abnormal wound healing, keloid formation, general fibrosis of the kidney, bladder, prostate, skin, liver, lung, heart, intestines or any other localized or generalized fibrotic ...
Methods of treatment of fibrosis and cancers
Genfit
August 24, 2017 - N°20170239213

The present invention relates to the use of compound 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethyl-methyloxyphenyl]prop-2-en-1-one for treating fibrotic diseases and cancers.
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Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and ...
Nissan Chemical Industries, Ltd.
August 17, 2017 - N°20170233321

There is provided a novel intermediate for producing pesticides. A method for producing the compound of formula (3) comprises reacting an aromatic ketone compound of formula (4) and a substituted acetophenone compound of formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. ...
Prevention of tumour metastasis by inhibition of necroptosis
Max-planck-gesellschaft Zur FÖrderung Der Wissenschaften E.v.
August 10, 2017 - N°20170226514

The present invention relates to an inhibitor of necroptosis for use in preventing the metastasis of tumours. Further, the present invention relates to a method of preventing the metastasis of tumours by inhibiting necroptosis and to a method for modulating the transmigration of metastasising tumour cells through endothelium by modulating necroptosis as well as to an in-vitro method of identifying ...
Methods for decreasing the incidence of necrotizing enterocolitis in infants, toddlers, or children using human ...
Abbott Laboratories
August 10, 2017 - N°20170224714

Disclosed are methods of reducing the incidence of necrotizing enterocolitis in an infant, toddler, or child using nutritional compositions including human milk oligosaccharides. The nutritional compositions including the human milk oligosaccharides are effective in reducing inflammation and the incidence of inflammatory diseases.
6-aryl amino pyridone formamide compound crystal and preparation method therefor
Centaurus Biopharma Co., Ltd.
August 03, 2017 - N°20170217979

The present invention provides a crystal of 6-arylamino pyridone carboxamide compound and a preparation method thereof. The crystal is obtained by dissolving 6-(2-chloro-4-iodophenylamino)-n-(2-hydroxylethyoxyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-carboxamide in an aprotic polar solvent and adding a second solvent thereto. The crystallization method has the advantage of simple and convenient operations, and is beneficial to ...
Monounsaturated fatty acid compositions and use for treating atherosclerosis
Burke & Boyer Nyc
August 03, 2017 - N°20170216237

Compositions comprising high concentration of monounsaturated fatty acids having low melting points and high iodine values and use of such compositions as dietary supplements, nutraceuticals or pharmaceuticals for reducing atherosclerotic plaque in mammals. It has been found that high concentrations of monounsaturated fatty acids (mufas) having low melting point temperatures and iodine values of about 50 to about 130 can be used ...
Anti-pdgfr-beta antibodies and uses thereof
Regeneron Pharmaceuticals, Inc.
July 27, 2017 - N°20170210813

The present invention provides antibodies that bind to platelet derived growth factor receptor beta (pdgfr-beta) and methods of using the same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human pdgfr-beta with high affinity. The antibodies of the invention are useful for the treatment of diseases and disorders associated with pdgfr-beta signaling ...
Aplnr modulators and uses thereof
Regeneron Pharmaceuticals, Inc
July 27, 2017 - N°20170210800

The present invention provides apelin receptor (aplnr) modulators that bind to aplnr and methods of using the same. The invention includes aplnr modulators such as antibodies, or antigen-binding fragments thereof, which inhibit or attenuate aplnr-mediated signaling. The invention includes aplnr modulators such as antibodies, or antibody fusion proteins thereof, that activate aplnr-mediated signaling. According to certain embodiments of the invention, ...
Systems and methods for transcatheter aortic valve treatment
Silk Road Medical, Inc.
July 27, 2017 - N°20170209260

Devices and methods are configured to allow transcervical or subclavian access via the common carotid artery to the native aortic valve, and implantation of a prosthetic aortic valve into the heart. The devices and methods also provide means for embolic protection during such an endovascular aortic valve implantation procedure.
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