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|| List of recent Roti-related patents
| Dosage forms of halofuginone and methods of use|
Oral and parenteral dosage forms comprising halofuginone, including enteric-coated solid oral dosage forms, subcutaneous dosage forms and intravenous dosage forms, for administration to subjects in need thereof, e.g., subjects having been identified with musculoskeletal disorders, fibrotic diseases, malaria, or cancer are described herein.. .
Halo Therapeutics, Llc.
| Organophosphates for treating afflictions of the skin|
Embodiments of the invention involve treating skin afflictions by the topical or oral use of organophosphates. By effectively reducing or eliminating the population of demodex mites in affected skin areas and areas where demodex mites may exist, this treatment achieves a more complete remission of clinical signs and symptoms of the skin afflictions than any previously described method.
| Therapeutic burn gel|
Therapeutic radiation burn gel is an invention that promotes the healing of radiated skin. It works by softening the layers of necrotic tissue which form (in the skin) post radiation.
| Imaging-aided gene therapy using mesenchymal stem cells as target-delivery vehicle|
Compositions and methods of use thereof encompass engineered mesenchymal stem cells as a vehicle to deliver secreted tissue necrosis factor-rgd4c fusion polypeptides for tumor treatment, thereby reducing side effects of tnf. A reporter gene can be included in vector constructs to monitor the localization and viability of engineered mscs after administration into a recipient animal.
The Board Of Trustees Of The Leland Stanford Junior University
|Atherosclerotic plaque detection|
An apparatus detects atherosclerotic plaques. The apparatus includes an electronic processing device that determines a level of fluorescence sensed by a sensor at a second infrared wavelength in response to exposure of at least part of an artery to radiation at a first infrared wavelength and determines a fluorescence indicator using the level of fluorescence.
Baker Idi Heart & Diabetes Institute Holdings Limited
|Multi-target modulation for treating fibrosis and inflammatory conditions|
The present invention relates to compositions comprising one or more active agents that selectively modulate the expression of two or more genes, for example at the post-transcription level, that are involved in fibrosis and/or inflammatory conditions. Also provided are methods of using such compositions for treating fibrotic diseases, as well as other diseases including inflammatory diseases and cancer..
|Use of secretor, lewis and sialyl antigen levels in clinical samples as predictors of risk for disease|
An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the h-1, h-2, lewisb and lewisy antigens and derivatives thereof (e.g., a sialylated form of lewis a, lewis x, lewis b, lewis y; h-1, h-2, lewis a, lewis x, lewis b or lewis y)..
Instituto Nacional De Ciencias Medicas Y Nutricion
|N-alkoxyamide conjugates as imaging agents|
The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided.
Lantheus Medical Imaging, Inc.
There is provided in accordance with an exemplary embodiment of the invention a method and/or a device of treating tissue near a first lumen comprising inserting an energy emission element into a second lumen and delivering energy in an amount sufficient to cause one or more spaced apart areas of tissue damage at preselected locations in tissue near the first lumen. There is also provided a method and/or a device for treating a carotid artery wall, for example, to reduce signal conduction.
|Novel cholesterol metabolite, 5-cholesten, 3beta-25-diol, disulfate (25hcds) for therapy of metabolic disorders, hyperlipidemia, diabetes, fatty livers diseases and atherosclerosis|
5-cholesten, 3β, 25-diol, disulfate (25hcds) has been found to be an authentic pparγ agonist and lxr antagonist, and is used for the therapy of lipid disorders and inflammatory diseases, including without limitation fatty liver, inflammatory bowel, and atherosclerotic diseases.. .
Virgini Commonwealth University
Cell-seeded compositions and methods useful for treating bone regions
Compositions and methods for treating diseased or damaged bone, preferably ischemic and/or necrotic bone, include the use of a combination of endothelial progenitor cells and mesenchymal stem cells, desirably also in conjunction with a collagenous extracellular matrix tissue. Methods for preparation of such compositions are also described..
Angiotensins for treatment of fibrosis
The present invention provides, among other things, methods and compositions for treating or preventing fibrotic diseases, disorders or conditions based on angiotensin (1-7) polypeptides, and analogs or derivatives thereof. In some embodiments, compositions and methods for treating or preventing pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease (copd), asthma, cystic fibrosis, kidney fibrosis, liver fibrosis, systemic sclerosis, post-surgical adhesions, accelerating wound healing, and reducing or preventing scar formation are provided..
Tarix Pharmaceuticals Ltd.
Use of toll-like receptor-9 agonists, toll-like receptor-4 antagonists, and/or nuclear oligomerization domain-2 agonists for the treatment or prevention of toll-like receptor-4 associated disorders
The present invention relates to the use of a tlr9 agonist and/or a tlr4 antagonist and/or a nod2 agonist for treatment or prevention of disorders involving tlr4 activation, such as systemic sepsis and necrotizing enterocolitis.. .
University Of Pittsburgh - Of The Commonwealth System Of Highter Education
Cx3cr1-targeting imaging agents and their use in the diagnosis and treatment of disease
The present invention relates to cx3cr1-targeting imaging agents and their use in treatment and diagnosis of diseases. Single domain cx3cr1-targeting polypeptides linked to detection labels and their use in in vivo imaging of atherosclerotic plaques are described.
Pi3k inhibitors for treating fibrotic diseases
The present invention is directed to compounds or pharmaceutically acceptable salts thereof for use in the treatment of fibrotic diseases such as idiopathic pulmonary fibrosis (ipf).. .
Glaxosmithkline Intellectual Property (no.2) Limited
Atherosclerosis characterization using a multi-contrast mri sequence
The present invention relates to imaging and characterizing atherosclerotic lesions. The invention utilizes a low-flip-angle gradient echo-based mri acquisition technique combined with specialized magnetization preparative schemes (i.e.
Cedars-sinai Medical Center
Percutaneous methods and devices for carotid body ablation
Methods and percutaneous devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via percutaneous carotid body ablation.. .
Pharmaceutical cream compositions and methods of use
Embodiments relating to cream formulations as well as oxymetazoline creams and methods for treating rosacea and symptoms associated with rosacea, including, for example, papules, pustules, phymas (skin thickening), telangiectasias or erythema associated with rosacea, other skin erythemas, telangiectasias, purpura or the like, and other manifestations associated therewith; other inflammatory conditions of the skin including, but not limited to, keratosis pilaris, lupus miliaris dissemniatus faciei, eczema, dermatitis, such as contact dermatitis, atopic dermatitis, seborrheic dermatitis, nummular dermatitis, generalized exfoliative dermatitis, statis dermatitis, neurodermatitis, lichen simplex chronicus, xerosis and xerotic dermatitis, dyshidrosis and dyshidrotic dermatitis, asteototic dermatitis or other conditions characterized by sensitive skin or a disturbance of the epidermal barrier; disorders characterized by rough, dry, cracked or fissured skin, disorders characterized by hyperkeratotic skin such as keratodermas and ichthyosisis and ichthyosiform dermatoses; disorders of hair follicles and sebaceous glands, such as acne, perioral dermatitis, and pseudofolliculitis barbae; disorders of sweat glands, such as miliaria, including, but not limited to, miliaria crystallina, miliaria rubra, miliaria profunda, miliaria pustulosa; sunburn, chronic actinic damage, poikiloderma, radiation dermatitis, actinic purpura (“solar purpura”); other inflammatory dermatoses, reactions and conditions of the skin, including, but not limited to, psoriasis, drug eruptions, erythema multiforme, erythema nodosum, and granuloma annulare; diseases and conditions characterized by bleeding or bruising such as petechiae, ecchymosis, purpura and the like including any accumulation of blood in the skin due to vascular extravasation, irrespective of size or cause, bleeding or bruising due to any skin injury which may include any trauma including surgical or procedural trauma; infection, inflammatory dermatoses or inflammation due to any cause using such creams are described herein.. .
Pharmaceutical composition for preventing or treating arteriosclerosis
The present invention provides a pharmaceutical composition for preventing or treating arteriosclerosis, comprising: a pharmaceutically effective amount of a protein comprising the amino acid sequence of seq id no: 1; and a pharmaceutically acceptable carrier. The composition of the present invention exhibits no toxicity in the liver or kidney and effectively reduces the formation of atherosclerotic plaques, thereby exhibiting efficacy in treating arteriosclerosis..
Novel use of pipoxolan and its pharmaceutical composition
The present disclosure concerns the novel use of pipoxolan and its pharmaceutical composition. Pipoxolan is useful therapeutic drugs for pathological conditions caused by vascular smooth muscle cell proliferation and migration to relieve a body appeared vascular injury, cerebrovascular ischemia, intimal hyperplasia, atherosclerotic stenosis, cerebral ischemia, and stroke..
China Medical University
Carotid stent assembly and methods for treatment via body lumens
A stent assembly adapted to carotid arterial placement that includes a self-expanding support element comprising metal struts constructed to be positioned in a body lumen and expanded from a retracted state to an expanded state, and a knitted cover disposed over an exterior of the support element and along an entire length thereof, wherein the knitted cover comprises a single polymer fiber having a diameter of at least 40 nanometers to 30 microns, wherein the self-expanding support element and knitted cover together have apertures sized 20 microns to smaller than 100 microns in diameter to block larger debris when the stent assembly is placed in a carotid artery and expanded to the expanded state. Methods of stenting a carotid artery by applying the stent assembly to the carotid artery of a patient in need of treatment and expanding the stent assembly in situ are disclosed..
Method and treating a carotid artery
One disclosed embodiment comprises a method for treating lesions in the carotid artery of a mammalian body. The method comprises transcervical access and blocking of blood flow through the common carotid artery (with or without blocking of blood flow through the external carotid artery), shunting blood from the internal carotid artery and treating the lesion in the carotid artery..
Silk Road Medical, Inc.
Method of implanting an aortic stent
A method of implanting an aortic stent comprising steps of: putting a main tube on a metal guide wire; moving the main tube along the metal guide wire to the descending aorta, the main tube is constrained by a first cover, and first and second tube bifurcations are branched from the main section; removing the first cover; inserting a second and third metal guide wire through the first tube bifurcation into the ascending aorta and branchiocephalic artery respectively; a first and a second tube branch moving into the ascending aorta and the branchiocephalic artery respectively; inserting a fourth and fifth metal guide wire through the first tube bifurcation into the ascending aorta and branchiocephalic artery respectively; a third and a fourth tube branch moving into left common carotid artery and the left subclavian artery respectively; removing a second cover constraining said tube branches.. .
Pharmaceutical formulations of xanthine or xanthine derivatives, and their use
The present invention relates to pharmaceutical formulations comprising xanthine or xanthine derivatives, kits thereof, and methods for treating fibrotic diseases by local administration.. .
Imprimis Pharmaceuticals, Inc.
Supercritical guggul extracts and uses thereof
The subject invention pertains to supercritical carbon dioxide extracts of commiphora mukul resin (guggul), which can be modified or not modified by some ethanol addition; methods for their production; and methods of use, such as inhibiting hmg-coa reductase, inhibiting transformation of pre-adipocytes to adipocytes, inhibiting triglyceride storage, promoting insulin sensitivity in adipocytes, treatment of disorders (for example, hypercholesterolemia, hyperlipidemia, hyperglycemia, obesity, metabolic syndrome, cardiovascular disease, atherosclerotic heart disease, autoimmune disorder, insulin resistance, leptin resistance, arthritis, cell proliferation disorder, such as cancer and atherosclerosis; damaged skin, sores, cuts, rashes, bruises, dryness, burns, sunburn, radiation burn, and infection), and regulating or suppressing appetite.. .
Flavex Naturextrakte Gmbh
Detection of a leading stroke risk indicator
Embodiments of a system and method for detecting a leading stroke risk indicator using low-cost, non-contact visual computing methods are generally described herein. In some embodiments, a video camera is arranged to capture a video of a face of a subject to be evaluated for having a stroke risk indicator.
Sustained-release formulation of rotigotine
Provided herein are methods and compositions for producing formulations systemic delivery of dopamine agonists via the oral inhalation route. Specifically, provided herein are methods and compositions for a formulation of rotigotine that is suitable for administration via oral inhalation.
Map Pharmaceuticals, Inc.
Pulmonary administration of rotigotine
Provided herein are methods and compositions for producing formulations systemic delivery of dopamine agonists via the oral inhalation route. Specifically, provided herein are methods and compositions for a stable solution formulation of rotigotine that is suitable for administration via oral inhalation.
Map Pharmaceuticals, Inc.
Systems for characterizing atherosclerotic plaque and methods of using same
The present technology relates generally to systems for characterizing atherosclerotic plaque, such as a spectral ct system, and methods of using same.. .
University Of Washington Through Its Center For Commercialization
Methods and systems for establishing retrograde carotid arterial blood flow
Interventional procedures on the carotid arteries are performed through a transcervical access while retrograde blood flow is established from the internal carotid artery to a venous or external location. A system for use in accessing and treating a carotid artery includes an arterial access device, a shunt fluidly connected to the arterial access device, and a flow control assembly coupled to the shunt and adapted to regulate blood flow through the shunt between at least a first blood flow state and at least a second blood flow state.
Silk Road Medical, Inc.
Estimation and display for vector doppler imaging using plane wave transmissions
Vector doppler imaging (vdi) improves on conventional color doppler imaging (cdi) by giving speed and direction of blood flow at each pixel of a display generated by a computing system. Multiple angles of plane wave transmissions (pwt) via an ultrasound transducer conveniently give projected doppler measurements over a wide field of view, providing enough angular diversity to identify velocity vectors in a short time window while capturing transitory flow dynamics.
Ultrasound diagnostic device and controlling ultrasound diagnostic device
An ultrasound diagnostic device for measuring a carotid artery wall property includes a transmission-reception processor, a transverse cross-sectional image generator, a transverse cross-sectional image selector, and a relative angle calculator. The transmission-reception processor performs transmission and reception processing of ultrasound with respect to the carotid artery.
Konica Minolta, Inc.
Method for diganosing atherosclerotic plaques by measurement of cd36
The present invention relates to diagnosis, classification and monitoring of atherosclerotic plaques in an individual using measurement of the concentration of cd36 in a body fluid and/or the plaque as such. The present invention also relates to diagnosing the burden of atherosclerotic plaques in an individual.
Methods and devices for embolic protection
An aortic flow diverter or filter is described that diverts particles away from the carotid vessels and right subclavian artery. The diverter includes a stent-like portion formed from a plurality of braided or woven wires that can radially self-expand.
Formulation having mobilizing activity
The present innovation relates to a novel formulation capable of increasing the amount of stem cells and progenitor cells in circulation in the peripheral blood of a mammal; the formulation is characterized in that it contains defibrotide in combination with at least one haematopoietic factor having the capacity to mobilize haematopoietic progenitors, preferably g-csf. In one embodiment, the formulation includes two separately administrable formulations, one containing a haematopoietic factor having the capacity to mobilize haematopoietic progenitors and the other containing defibrotide.
Carotid body ablation via directed energy
Methods and devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via carotid body ablation.. .
Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases
The present methods and compositions are of use for treatment of conditions involving fibrosis, such as peyronie's disease plaque, penile corporal fibrosis, penile veno-occlusive dysfunction, dupuytren's disease nodules, vaginal fibrosis, clitoral fibrosis, female sexual arousal disorder, abnormal wound healing, keloid formation, general fibrosis of the kidney, bladder, prostate, skin, liver, lung, heart, intestines or any other localized or generalized fibrotic condition, vascular fibrosis, arterial intima hyperplasia, atherosclerosis, arteriosclerosis, restenosis, cardiac hypertrophy, hypertension or any condition characterized by excessive fibroblast or smooth muscle cell proliferation or deposition of collagen and extracellular matrix in the blood vessels and/or heart. In certain embodiments, the compositions may comprise a pde-4 inhibitor, a pde-5 inhibitor, a compound that elevates cgmp and/or pkg, a stimulator of guanylyl cyclase and/or pkg, a combination of a compound that elevates cgmp, pkg or no with an antioxidant that decreases ros, or a compound that increases mmp activity..
Materials and methods for detecting and/or predicting necrotizing enterocolitis in infants
The subject invention pertains to materials and methods for diagnosing and/or predicting pathologic infant conditions. A method of the invention comprises obtaining a biological sample from an infant and analyzing the sample to detect at least one protein biomarker of necrotizing enterocolitis (nec), wherein a patient is diagnosed with nec or determined to have a likelihood of developing nec following detection of the biomarker.
Formulations for the treatment of diabetes
Disclosed is a formulation for parenteral administration comprising insulin that comprises a ph memory between 1 to 4 or between 6 to 8 and an aprotic polar solvent, wherein the insulin is solubilized in the aprotic polar solvent, wherein the solubilized insulin comprises stable monomeric or dimeric forms of insulin or mixtures thereof, and wherein the water content of the formulation is equal to or less than 15% w/v.. .
Methods and devices for non-invasive cerebral and systemic cooling
Methods for cerebral cooling are described. Cooling assemblies include elongate tubular members, a reservoir containing a pressurized fluid, and a manifold connecting the reservoir and elongate tubular members.
Antitubercular composition and producing same
The invention relates to the field of pharmaceutics and medicine and concerns a medicinal composition of antitubercular preparations with a phospholipid transport system, the composition consisting of a fatty acid salt, phosphatidylcholine of vegetative origin (73-97%), maltose and an antitubercular agent selected from rifamycin, protionamide, rifabutin and rifapentine, and a method for producing the composition.. .
Discrimination method and apparatus of cardiac tissue using raman scattering
A method and an apparatus for discriminating a cardiac tissue using raman scattering are provided which enable a noninvasive discrimination of the cardiac tissue to be accurately performed. The discrimination method includes: a step of irradiating a sample containing a cardiac tissue with excitation light; a step of detecting raman scattering light from the sample; an analysis step of analyzing the detected raman scattering light by a multivariate analysis using as an index, raman scattering spectra which are specific to at least a living myocardial tissue, a necrotic myocardial tissue, a granulation tissue and a fibrotic tissue, respectively; and a step of discriminating the cardiac tissue in accordance with analysis results obtained in the analysis step..
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