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Roti-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Molecular nets and devices for capturing analytes
Sevident, Inc.
May 24, 2018 - N°20180143188

Disclosed is a covalently-linked multilayered three-dimensional matrix comprising capture molecules, linkers and spacers (referred to as a molecular net) for specific and sensitive analyte capture from a sample. Also disclosed herein is a molecular net comprising covalently-linked multilayered three-dimensional matrix comprising more than one type of capture molecule and more than one type of linker and may comprise one or ...
NEW Using structural variation to analyze genomic differences for the prediction of heterosis
E. I. Du Pont De Nemours And Company
May 24, 2018 - N°20180142309

A novel method for prediction of the degree of heterotic phenotypes in plants is disclosed. Structural variation analyses of the genome are used to predict the degree of a heterotic phenotype in plants.
NEW Modulation of angiopoietin-like 3 expression
Ionis Pharmaceuticals, Inc.
May 24, 2018 - N°20180142244

Provided herein are methods, compounds, and compositions for reducing expression of an angptl3 mrna and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing plasma lipids, plasma glucose and atherosclerotic plaques in an animal.
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NEW Heterocyclic compounds as kinase inhibitors
Translational Drug Development Llc
May 24, 2018 - N°20180141959

The present invention is directed to certain amides and heterocyclic compounds. The present invention also relates to uses of these compounds to treat several diseases including autoimmune disorders, cardiovascular disorders, inflammation, central nervous system disorders, arterial thrombotic disorders, fibrotic disorders, glaucoma, and neoplastic disorders..
NEW Novel small molecule fiel1 inhibitor in inflammatory and fibrotic lung injury
University Of Pittsburgh - Of The Commonwealth System Of Higher Education
May 24, 2018 - N°20180141916

Novel compounds are disclosed along with methods of inhibiting the tgfβ pathway and methods of treating idiopathic pulmonary fibrosis (ipf) using such compounds.. .
NEW Oxidized carotenoids and components thereof for preventing necrotic enteritis
Avivagen Inc.
May 24, 2018 - N°20180139985

Necrotic enteritis (ne) has been largely found in commercial broiler chickens when they are produced without the use of antimicrobial growth promoters. The present invention provides a method and use of oxidized carotenoids, components thereof and compositions and products containing same, such as oxbc ('oxc-beta™, product from avivagen inc., canada) for preventing necrotic enteritis in animals, such as poultry.
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Inhibition of gliadin peptides
Alba Therapeutics Corporation
May 17, 2018 - N°20180134750

Novel compounds and methods for the inhibition of biological barrier permeability and for the inhibition of peptide translocation across biological barriers are identified. Assays for determining modulators of biological barrier permeability and for peptide translocation across biological barriers are provided.
Methods and systems for treatment of acute ischemic stroke
Route 92 Medical, Inc.
May 17, 2018 - N°20180133436

A system of devices for treating an artery includes an arterial access sheath adapted to introduce an interventional catheter into an artery and an elongated dilator positionable within the internal lumen of the sheath body. The system also includes a catheter formed of an elongated catheter body sized and shaped to be introduced via a carotid artery access site into ...
Therapeutic ozone agent and treatment
May 17, 2018 - N°20180133248

The use of a medical therapeutic ozone agent in vivo to treat a variety of disorders including, but not limited to hypoxic conditions, autoimmune disease, fibrotic disease, inflammatory disease, neurodegenerative disease, infectious disease, lung disease, heart and vascular disease, metabolic disease, and cancer, wherein the therapeutic ozone agent is administered in a therapeutically effective amount, which can convert carbon monoxide ...
Systems for removal of atherosclerotic plaque or thrombus
W.l. Gore & Associates, Inc.
May 17, 2018 - N°20180132872

A system for removing plaque or thrombus from the vasculature and/or deployed medical devices is described. An embodiment can include a plaque reduction brush comprising at least one support adapted to allow the brush to be endoluminally deliverable via a delivery device to a treatment site; and a plurality of bristles extending from the at least one support and ...
Reversible aminal gel compositions, methods, and use
Saudi Arabian Oil Company
May 10, 2018 - N°20180127634

A well treatment composition for use in a hydrocarbon-bearing reservoir comprising a reversible aminal gel composition is disclosed. The reversible aminal gel composition includes a liquid precursor composition.
Novel cholesterol metabolite, 5-cholesten, 3beta-25-diol, disulfate (25hcds) for therapy of metabolic disorders, hyperlipidemia, diabetes, ...
Virginia Commonwealth University
May 10, 2018 - N°20180127457

5-cholesten, 3β,25-diol, disulfate (25hcds) has been found to be an authentic pparγ agonist and lxr antagonist, and is used for the therapy of lipid disorders and inflammatory diseases, including without limitation fatty liver, inflammatory bowel, and atherosclerotic diseases.. .
Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
May 10, 2018 - N°20180127425

Wherein r1a, r1b, r2, r4, r5, r6, r7, r8, w, x, y, z, cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (npp2 or enpp2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving ...
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Liver cirrhosis treatment
May 10, 2018 - N°20180125950

A method of treating liver cirrhosis has ‘micro-cuts’ being created within the parenchyma of a cirrhotic liver to create ‘micro-cavities’, so that hepatocytes have more ‘room’ to regenerate; and thus an overall increase in hepatocyte volume occurs. Alternatively, the method of treating liver cirrhosis has fibrotic collagen being disrupted enzymatically (eg collagenase) through localized ...
Natural pharmaceutical composition for treating osteoporotic fracture and/or osteoarthritis and use thereof
Shaanxi Tiankui Biomedicine Technology Limited Company
May 10, 2018 - N°20180125907

The present disclosure discloses a natural pharmaceutical composition for treating osteoporotic fracture and/or osteoarthritis and an application thereof. The composition is composed of 73.3 wt %-98.3 wt % of sea buckthorn pulp oil and 1.7 wt %-26.7 wt % of panax notoginseng saponins.
Treatment for hepatic fibrosis
Galmed Research And Development Ltd.
May 10, 2018 - N°20180125862

The invention relates to the treatment and reduction of fibrosis, specifically hepatic fibrosis. More specifically, embodiments of the invention provide compositions and methods useful for the treatment and inhibition of hepato-fibrotic conditions associated with non-alcoholic fatty liver disease (nafld) and non-alcoholic steatohepatitis (nash), employing the use of 3β-arachidylamido-7α,12α-dihydroxy-5β-cholan-24-oic acid (...
Liquid formulations of bendamustine
May 10, 2018 - N°20180125824

Stable liquid formulations of bendamustine, and pharmaceutically acceptable salts thereof, and polar aprotic solvents, are described.. .
Prosthetic apparatus and systems for total knee arthroplasty
May 10, 2018 - N°20180125667

Disclosed are various apparatus and systems by which a ball and socket joint s interposed between prosthetic medial and lateral femorotibial articulations, permitting multidirectional movement and rotation as well as weight-bearing characteristics. Some embodiments have fixed components, while others are modular or quasi-modular in nature.
Intravascular catheter having an expandable incising portion for incising atherosclerotic material located in a blood ...
May 10, 2018 - N°20180125526

A method for performing balloon catheterization of a zone of attention is provided. An intravascular device has an expandable portion secured to a distal end of a catheter tube.
Intravascular catheter with incising devices
May 10, 2018 - N°20180125525

An intravascular device is provided having a flexible catheter tube with an expandable portion located on an end thereof. The expandable portion has a plurality of struts capable of being moved between an expanded and a collapsed position.
Novel aryl-cyanoguanidine compounds
Bayer Pharma Aktiengesellschaft
May 03, 2018 - N°20180118722

The present invention relates to protein-lysine n-methyltransferase smyd2 (set and mynd domain-containing protein 2) inhibitors, in particular smyd2-inhibitory substituted cyanoguanidine-pyrazolines of general formula (i), wherein r1, r3, r4, r5 and n have the meaning as described and defined herein, as well as to pharmaceutical compositions comprising compounds according to the invention and to their prophylactic and therapeutic use for hyperproliferative ...
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