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Roti patents



      
           
This page is updated frequently with new Roti-related patent applications. Subscribe to the Roti RSS feed to automatically get the update: related Roti RSS feeds. RSS updates for this page: Roti RSS RSS


Therapeutic collar

Neuron Guard S.r.l.

Therapeutic collar

Vascular neck restraint training device

Vascular neck restraint training device


Date/App# patent app List of recent Roti-related patents
08/27/15
20150238763 
 Electrode structures and methods for their use in cardiovascular reflex control patent thumbnailElectrode structures and methods for their use in cardiovascular reflex control
Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus.
Cvrx, Inc.


08/27/15
20150238349 
 Therapeutic collar patent thumbnailTherapeutic collar
A therapeutic collar comprising an elongate body made from a flexible material for extending around at least a portion of the neck of a patient. The body has a length approximating the circumference of the neck, two thermoelectric devices for overlying two carotid arteries in the neck and two thermoelectric devices for overlying of two vertebral arteries in the neck when the elongate body is secured around the neck of the patient.
Neuron Guard S.r.l.


08/20/15
20150235570 
 Vascular neck restraint training device patent thumbnailVascular neck restraint training device
A vascular neck restraint training device is used for raining a first person to execute a vascular neck restraint on a second person. The training device includes a supporting structure, such as a collar for being supported about the neck of the second person, upon which a tracheal pressure sensor, and two arterial pressure sensors are supported for alignment with the trachea and the carotid arteries of the second person respectively.

08/20/15
20150232842 
 Treatment of fibrotic conditions patent thumbnailTreatment of fibrotic conditions
Treatment of fibrosis and fibrotic diseases, disorders, and conditions, and associated methods, compositions, formulations and articles.. .
Coda Therapeutics, Inc.


08/20/15
20150230855 
 Method of destroying tissue cells by electroporation patent thumbnailMethod of destroying tissue cells by electroporation
An apparatus and method for performing noninvasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical, contact with the patient's skin for applying the pulses to the patient's skin.
Angiodynamics, Inc.


08/20/15
20150230774 
 Blood pressure monitor and method patent thumbnailBlood pressure monitor and method
A method is provided for noninvasive, continuous, real-time monitoring of a patient's arterial blood pressure using doppler probes and a blood pressure cuff for measurement of a patient's systolic and diastolic blood pressures at a major distal artery. A continuous doppler blood flow velocity measurement is used to generate a waveform signal correlating to a cuff's measurements of systolic and diastolic pressures.

08/13/15
20150224289 
 Treatment of renal hypertension or carotid sinus syndrome with adventitial pharmaceutical sympathetic denervation or neuromodulation patent thumbnailTreatment of renal hypertension or carotid sinus syndrome with adventitial pharmaceutical sympathetic denervation or neuromodulation
Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population.
Mercator Medsystems, Inc.


07/23/15
20150203537 
 Inhibition of gliadin peptides patent thumbnailInhibition of gliadin peptides
Novel compounds and methods for the inhibition of biological barrier permeability and for the inhibition of peptide translocation across biological barriers are identified. Assays for determining modulators of biological barrier permeability and for peptide translocation across biological barriers are provided.
Alba Therapeutics Corporation


07/23/15
20150203483 
 2,3-benzodiazepines patent thumbnail2,3-benzodiazepines
In which r1a, r1b, r1c, r2, r3, r4, r5, a and x have the meanings given in the description, intermediates for preparing the compounds according to the invention, pharmaceutical compositions comprising the compounds according to the invention and their prophylactic and therapeutic use for hyperproliferative disorders, in particular for tumour disorders. Also described is the use of bet protein inhibitors for benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, for neurodegenerative disorders, for inflammatory disorders, for atherosclerotic disorders and for the control of male fertility..

07/23/15
20150202444 
 Systems and methods for selective stimulation of nerve fibers in carotid sinus patent thumbnailSystems and methods for selective stimulation of nerve fibers in carotid sinus
An example of a system may include at least one electrode for placement on tissue in a carotid sinus region and a stimulator. The stimulator may be configured to use the at least one electrode to deliver neural stimulation to a baroreceptor region or at least one nerve innervating the baroreceptor region in the carotid sinus region to elicit a baroreflex response, and to deliver a blocking stimulation to a carotid body or at least one nerve innervating the carotid body in the carotid sinus region to inhibit a chemoreceptor response, the stimulator configured to simultaneously deliver the neural stimulation and the blocking stimulation..
Cardiac Pacemakers, Inc.


07/23/15
20150202260 

Endoglin peptides to treat fibrotic diseases


In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a truncated, ligand-binding portion of the extracellular domain of endoglin (eng) polypeptide may be used to treat fibrotic disorders.. .
Acceleron Pharma, Inc.


07/16/15
20150197603 

Process for the preparation of polyquarternium-l


The present invention relates to a method for the preparation of polyquaternium-1, wherein an aprotic polar solvent is used as the reaction medium, and a solid polyquaternium-1 having a low degree of polydispersity.. .
Alfred E. Tiefenbacher (gmbh & Co. Kg)


07/16/15
20150196580 

Use of defibrotide for the inhibition of heparanase


A study has been carried out to verify the effect of defibrotide on the activity and expression of heparanase enzyme on myeloma tumor cells (u266) and human microvascular endothelial cells (hmec). The study has demonstrated that defibrotide can be effectively used for the manufacture of a medicament for the treatment of diseases which are positively affected by the inhibition of heparanse and/or by the downregulation of heparanse gene expression, such as diabetes..
Gentium Spa


07/09/15
20150190267 

Patient treatment system


A patient treatment system for treating a patient includes a cervical collar having a first opening located over a trachea of the patient and a second opening located over a carotid artery of the patient. An aid is disposed in the second opening and includes a base having a curved surface; the base is disposed proximal to a neck of the patient over the carotid artery.
Medical Science Technologies Llc


07/02/15
20150182614 

Vaccine for prophylaxis or treatment of an allergen-driven airway pathology


The present invention relates to a life attenuated bordetella pertussis vaccine which is deficient for tracheal cytotoxin (tct), pertussis toxin (ptx), and dermonecrotic toxin (dnt) for prophylaxis or treatment of an allergen-driven airway pathology.. .
National University Of Ireland Maynooth


06/25/15
20150177244 

Parallel analysis of serum epcam and mmp7 to discriminate sepsis, necrotizing enterocolitis and normal control patients


Methods and compositions are provided for making a necrotizing enterocolitis (nec) or sepsis assessment of an individual. Aspects of the methods include detecting a biomarker or panel of biomarkers selected from mmp7, epcam, and crp.
The Board Of Trustees Of The Leland Stanford Junior University


06/25/15
20150176003 

Euglobulin-based determining the biological activity of defibrotide


It is disclosed a method for determining the biological activity of defibrotide, which comprises the steps of: a) bringing into contact defibrotide, mammalian euglobulin and a substrate specific for the plasmin which, by reaction with the plasmin, provides a measurable product; and b) measuring the amount of product formed at successive times, to thereby determine the biological activity of the defibrotide. Liquid defibrotide formulations are also disclosed, preferably water solutions, having a defined biological activity and, in particular, having an activity of 25 to 35 iu/mg of defibrotide, preferably from 27.5 to 32.5 iu/mg and, more preferably, from 28 to 32 iu/mg..
Gentium S.p.a.


06/25/15
20150175675 

Fusion polypeptides and methods of use thereof


The present invention also provides fusion polypeptides with a carboxy-terminal or n-terminal peptide domain (e.g., fc, ctp, or fc-ctp), and nucleic acid molecules encoding these polypeptides. The present invention further provides for methods of using the compositions of the invention for treatment of cancer and fibrotic diseases.
The Trustees Of Columbia University In The City Of New York


06/25/15
20150175597 

Apoptosis signal-regulating kinase inhibitors


The present application relates to compounds having the inhibitory activity to apoptosis signal-regulating kinase (ask1), thus are thus useful in treating ask1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, copd, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver diseases, and neurodegenerative diseases.. .
Gilead Sciences, Inc.


06/25/15
20150174368 

Transcarotid neurovascular catheter


An interventional catheter for treating an artery includes an elongated body sized and shaped to be transcervically introduced into a common carotid artery at an access location in the neck. The elongated body has an overall length such that the distal most section can be positioned in an intracranial artery and at least a portion of the proximal most section is positioned in the common carotid artery during use..
Silk Road Medical, Inc.


06/25/15
20150174266 

Aprotinin polypeptides for transporting a compound across the blood-brain barrier


The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptides derived from aprotinin and from aprotinin analogs as well as conjugates and pharmaceutical compositions comprising these polypeptides or conjugates.
Angiochem Inc.


06/25/15
20150174183 

Methods and pomegranate extract composition for treating diabetes related atherosclerotic complications in humans


One or more embodiments of the invention are directed to methods of using pomegranate extracts for treating diabetes related atherosclerotic complications in humans. The methods comprise the step of administering to the patients a composition comprising a therapeutically effective amount of an extract from pomegranate..
Pom Wonderful, Llc


06/25/15
20150173782 

Methods and systems for treatment of acute ischemic stroke


A system of devices for treating an artery includes an arterial access sheath adapted to introduce an interventional catheter into an artery and an elongated dilator positionable within the internal lumen of the sheath body. The system also includes a catheter formed of an elongated catheter body sized and shaped to be introduced via a carotid artery access site into a common carotid artery through the internal lumen of the arterial access sheath.
Silk Road Medical, Inc.


06/18/15
20150164907 

Compositions and methods for treating disease


Methods are provided for treating fibrotic diseases and conditions or cancer and other dysproliferative diseases by administering to a subject in need there of a therapeutically effective amount of a synergistic composition comprising a phosphatidylinositol 3-kinase inhibitor and a retinoid, optionally including a cyp26 inhibitor, wherein the therapeutically effective amount suppresses fibrosis or the growth of dysproliferative cells in vivo. Compositions comprising a combination of a phosphatidylinositol 3-kinase inhibitor and a retinoid, optionally in combination with a cyp26 inhibitor, are also described..
Angion Biomedica Corp.


06/11/15
20150158813 

Substituted 3-haloallylamine inhibitors of assao and uses thereof


Is described. Methods of using compounds of formula i, or pharmaceutically acceptable salt or derivatives thereof, for the treatment of a variety of indications, e.g., inflammatory diseases, ocular diseases, fibrotic diseases, diabetes-induced diseases and cancer, are also described..

06/11/15
20150157477 

Device for endovascular aortic repair and using the same


An intraluminal vascular prosthesis assembly, having a hollow cylindrical body with a first end and a second end is provided. The assembly includes, at its first end, a first vascular prosthesis portion, and at its second end, a second vascular prosthesis portion which has only a prosthesis material.
Aortic Innovations, Llc


06/11/15
20150157346 

Restoring blood flow and clot removal during acute ischemic stroke


Devices for restoring blood flow to facilitate lysis of clots and/or enable capture of clots are disclosed. The devices can be configured to be disposed within a lumen of a microcatheter that is inserted within neurovasculature above a carotid siphon to a location of a clot.
Covidien Lp


06/04/15
20150152102 

Piperidinylpyrazolopyridine derivative


A compound represented by the general formula (i) or a pharmacologically acceptable salt thereof has an excellent lcat-activating effect and is useful as an active ingredient in a therapeutic or prophylactic agent for arteriosclerosis, arteriosclerotic heart disease, coronary heart disease (including heart failure, myocardial infarction, angina pectoris, cardiac ischemia, cardiovascular disturbance, and restenosis caused by angiogenesis), cerebrovascular disease (including stroke and cerebral infarction), peripheral vascular disease (including diabetic vascular complications), dyslipidemia, hypo-hdl-cholesterolemia, or renal disease, particularly, an anti-arteriosclerotic agent, wherein r is an optionally substituted aryl group or an optionally substituted heteroaryl group.. .
Daiichi Sankyo Company, Limited


06/04/15
20150150562 

Method and treating a carotid artery


One disclosed embodiment comprises a method for treating lesions in the carotid artery of a mammalian body. The method comprises transcervical access and blocking of blood flow through the common carotid artery (with or without blocking of blood flow through the external carotid artery), shunting blood from the internal carotid artery and treating the lesion in the carotid artery..
Silk Road Medical, Inc.


05/28/15
20150148682 

Non-contact thermometer sensing a carotid artery


Systems, methods and apparatus are provided through which in some implementations a non-contact thermometer determines a temperature of a subject from a carotid source point of the subject.. .
Brooklands, Inc.


05/21/15
20150141760 

Systems and methods for treating a carotid artery


Systems and methods are adapted for treating the carotid artery. The systems include interventional catheters and blood vessel access devices that are adapted for transcervical insertion into the carotid artery.
Silk Road Medical, Inc.


05/21/15
20150141501 

Ultrapure tetrahydrocannabinol-11-oic acids


This application is in the field of medicinal chemistry and relates to ultrapure ajulemic acid, its synthesis, pharmaceutical compositions and methods of use thereof for the treatment and/or prevention of inflammation, pain, and fibrotic diseases including scleroderma, systemic sclerosis, scleroderma-like disorders, sine scleroderma, liver cirrhosis, interstitial pulmonary fibrosis, idiopathic pulmonary fibrosis, dupuytren's contracture, keloids, chronic kidney disease, chronic graft rejection, and other scarring-wound healing abnormalities, post-operative adhesions, and reactive fibrosis.. .
Corbus Pharmaceutics Inc.


05/21/15
20150140161 

Methods of improving tolerance related to feeding in an infant, toddler, or child


Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component..
Abbott Laboratories


05/21/15
20150137032 

Process for producing heat-treated vinylidene fluoride polymer powder and process for producing vinylidene fluoride polymer solution


The present invention relates to a process for producing a vinylidene fluoride polymer solution, which involves dissolving heat-treated vinylidene fluoride polymer powder into an aprotic polar solvent. The heat-treated vinylidene fluoride polymer powder is obtained by heat treating raw vinylidene fluoride polymer powder at such a temperature that the temperature of the vinylidene fluoride polymer powder is not less than 125° c.
Kureha Corporation


05/14/15
20150132466 

Nutritional products including a novel fat system including fatty acids


Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component..

05/14/15
20150131889 

Necrotic cell region detection apparatus and the same, and non-transitory computer readable storage medium to store a necrotic cell region detection program


A necrotic cell region detection apparatus includes an image acquiring unit, a segmentation unit, a band separate unit, a feature value calculating unit, a luminance calculating unit, and a judging unit. The image acquiring unit acquires a cell image.

05/07/15
20150127068 

Nerve stimulator system


Devices, systems and methods for applying electrical impulse(s) to one or more selected nerves are described. An electrical stimulator is introduced through a to a target location within, adjacent to, or in close proximity with, the carotid sheath.
Electrocore, Llc


05/07/15
20150126622 

Blood biomarkers for necrotizing enterocolitis


Necrotizing enterocolitis (nec) biomarkers, nec biomarker panels, and methods for obtaining a nec signature for a sample are provided. Also provided are methods, compositions, and kits for making a necrotizing enterocolitis (nec) assessment of an individual, e.g.
The Board Of Trustees Of The Leland Stanford Junior University


04/30/15
20150119576 

Method for production of 3-hydroxypropan-1-one compound, production of 2-propen-1-one compound and production of isoxazoline compound


There is provided a novel intermediate for producing pesticides. A method for producing the compound of formula (3) comprises reacting an aromatic ketone compound of formula (4) and a substituted acetophenone compound of formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state.
Nissan Chemical Industries, Ltd.


04/30/15
20150118698 

Biochemical markers for cvd risk assessment


A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage ofmimecan, a protein of an atherosclerotic plaque, by a proteinase, said comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events..
Nordic Biociences A/s


04/30/15
20150118309 

Preparation for percutaneous absorption containing rotigotine


Exemplary embodiments of the present invention relate to a method for preparing a preparation for percutaneous absorption, which includes rotigotine as an active ingredient, and more specifically, to a method for preparing a preparation for percutaneous absorption including mixing rotigotine and an ethylene-vinyl acetate adhesive so as to have a weight ratio of 1:(0.1 to 20), a preparation for percutaneous absorption manufactured by the method, and a percutaneous treatment system. The preparation and the system may prevent separation of the rotigotine, thereby increasing long-term storage stability, and effectively release the rotigotine, and thus can be effectively applied to preparing patch medication containing the rotigotine..
Sk Chemicals Co., Ltd.


04/30/15
20150118282 

Transdermally absorbable preparation containing rotigotine


A method for preventing the precipitation of rotigotine crystals, including a step of mixing rotigotine and one or more crystallization prevention agents selected from the group consisting of fatty alcohols, fatty acids, fatty acid esters, fatty acid amides, and the derivatives thereof, and to a transdermally absorbable preparation that includes rotigotine and crystallization prevention agents.. .
Sk Chemicals Co., Ltd.


04/23/15
20150112359 

Electrical stimulation of the carotid artery


In order to treat hypertension, an implantable receiving device is connected to implantable leads which are adapted to deliver electrical energy to the carotid body or bodies of the patient. The receiving device is arranged to receive electoral energy from an external generator.
Bioinduction Limited


04/23/15
20150111947 

Compositions and methods for decreasing leukocyte extravasation and vessel fluid leakage


Provided herein are methods of decreasing leukocyte extravasation from a lymph or blood vessel into a tissue in a mammal, methods of decreasing fluid leakage from a lymph or blood vessel in a mammal in need thereof, methods of decreasing formation of atherosclerotic plaques in a mammal in need thereof, and methods of treating atherosclerosis in a mammal that include administering to the mammal an oligonucleotide that decreases mitogen-activated protein kinase kinase kinase kinase 4 (map4k4) mrna expression in an endothelial cell. Also provided are methods of identifying a candidate agent useful for decreasing leukocyte extravasation or decreasing fluid leakage from a lymph or blood vessel in a mammal, and compositions containing an oligonucleotide that decreases map4k4 mrna expression in an endothelial cell and additional therapeutic agents..
University Of Massachusetts


04/23/15
20150111872 

Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders


The present invention relates to compounds inhibiting autotaxin (npp2 or enpp2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, and/or abnormal angiogenesis associated diseases by administering the compound of the invention.. .

04/23/15
20150111824 

Pharmaceutical formulations comprising incretin mimetic peptide and aprotic polar solvent


The present disclosure is directed to stable pharmaceutical formulations and uses thereof.. .
Astrazeneca Pharmaceuticals Lp


04/23/15
20150110895 

Methods of treating necrotic enteritis


Methods of treating necrotic enteritis are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.. .
Liveleaf, Inc.


04/16/15
20150104462 

Use of semaphorin-4d binding molecules for treatment of atherosclerosis


Provided herein are methods for reducing, inhibiting, suppressing and/or delaying atherosclerotic plaque growth or neovascularization in a subject having atherosclerosis, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4d (sema4d) or to its high affinity plexin-b1 receptor.. .
Vaccinex, Inc.


04/09/15
20150099919 

Control of magnetic rotors to treat therapeutic targets


A system for the physical manipulation of free magnetic rotors in a circulatory system using a remotely placed magnetic field-generating stator is provided. In one embodiment, the invention relates to the control of magnetic particles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources.
Pulse Therapeutics, Inc.


04/02/15
20150094465 

N-alkoxyamide conjugates as imaging agents


The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided.
Lantheus Medical Imaging, Inc.


04/02/15
20150094384 

Methods for predicting and treating necrotizing enterocolitis in neonates


Embodiments are presented herein that provide early prediction of the development of necrotizing enterocolitis by a preterm infant through analysis of the high frequency component of heart rate variability, optionally with analysis of respiration rate. Methods of treatment following prediction area also reported..
The Penn State Research Foundation


03/26/15
20150086627 

Dosage forms of halofuginone and methods of use


Oral and parenteral dosage forms comprising halofuginone, including enteric-coated solid oral dosage forms, subcutaneous dosage forms and intravenous dosage forms, for administration to subjects in need thereof, e.g., subjects having been identified with musculoskeletal disorders, fibrotic diseases, malaria, or cancer are described herein.. .
Halo Therapeutics, Llc.


03/26/15
20150086596 

Organophosphates for treating afflictions of the skin


Embodiments of the invention involve treating skin afflictions by the topical or oral use of organophosphates. By effectively reducing or eliminating the population of demodex mites in affected skin areas and areas where demodex mites may exist, this treatment achieves a more complete remission of clinical signs and symptoms of the skin afflictions than any previously described method.

03/26/15
20150086529 

Therapeutic burn gel


Therapeutic radiation burn gel is an invention that promotes the healing of radiated skin. It works by softening the layers of necrotic tissue which form (in the skin) post radiation.

03/26/15
20150086515 

Imaging-aided gene therapy using mesenchymal stem cells as target-delivery vehicle


Compositions and methods of use thereof encompass engineered mesenchymal stem cells as a vehicle to deliver secreted tissue necrosis factor-rgd4c fusion polypeptides for tumor treatment, thereby reducing side effects of tnf. A reporter gene can be included in vector constructs to monitor the localization and viability of engineered mscs after administration into a recipient animal.
The Board Of Trustees Of The Leland Stanford Junior University


03/19/15
20150080686 

Atherosclerotic plaque detection


An apparatus detects atherosclerotic plaques. The apparatus includes an electronic processing device that determines a level of fluorescence sensed by a sensor at a second infrared wavelength in response to exposure of at least part of an artery to radiation at a first infrared wavelength and determines a fluorescence indicator using the level of fluorescence.
Baker Idi Heart & Diabetes Institute Holdings Limited


03/19/15
20150080320 

Multi-target modulation for treating fibrosis and inflammatory conditions


The present invention relates to compositions comprising one or more active agents that selectively modulate the expression of two or more genes, for example at the post-transcription level, that are involved in fibrosis and/or inflammatory conditions. Also provided are methods of using such compositions for treating fibrotic diseases, as well as other diseases including inflammatory diseases and cancer..
Aadigen, Llc


03/19/15
20150079055 

Use of secretor, lewis and sialyl antigen levels in clinical samples as predictors of risk for disease


An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the h-1, h-2, lewisb and lewisy antigens and derivatives thereof (e.g., a sialylated form of lewis a, lewis x, lewis b, lewis y; h-1, h-2, lewis a, lewis x, lewis b or lewis y)..
Instituto Nacional De Ciencias Medicas Y Nutricion


03/19/15
20150078997 

N-alkoxyamide conjugates as imaging agents


The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided.
Lantheus Medical Imaging, Inc.


03/12/15
20150073400 

Tissue treatment


There is provided in accordance with an exemplary embodiment of the invention a method and/or a device of treating tissue near a first lumen comprising inserting an energy emission element into a second lumen and delivering energy in an amount sufficient to cause one or more spaced apart areas of tissue damage at preselected locations in tissue near the first lumen. There is also provided a method and/or a device for treating a carotid artery wall, for example, to reduce signal conduction.
Cardiosonic Ltd.


03/12/15
20150072962 

Novel cholesterol metabolite, 5-cholesten, 3beta-25-diol, disulfate (25hcds) for therapy of metabolic disorders, hyperlipidemia, diabetes, fatty livers diseases and atherosclerosis


5-cholesten, 3β, 25-diol, disulfate (25hcds) has been found to be an authentic pparγ agonist and lxr antagonist, and is used for the therapy of lipid disorders and inflammatory diseases, including without limitation fatty liver, inflammatory bowel, and atherosclerotic diseases.. .
Virgini Commonwealth University


03/05/15
20150065947 

Cell-seeded compositions and methods useful for treating bone regions


Compositions and methods for treating diseased or damaged bone, preferably ischemic and/or necrotic bone, include the use of a combination of endothelial progenitor cells and mesenchymal stem cells, desirably also in conjunction with a collagenous extracellular matrix tissue. Methods for preparation of such compositions are also described..
Muffin Incorporated


02/26/15
20150057216 

Angiotensins for treatment of fibrosis


The present invention provides, among other things, methods and compositions for treating or preventing fibrotic diseases, disorders or conditions based on angiotensin (1-7) polypeptides, and analogs or derivatives thereof. In some embodiments, compositions and methods for treating or preventing pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease (copd), asthma, cystic fibrosis, kidney fibrosis, liver fibrosis, systemic sclerosis, post-surgical adhesions, accelerating wound healing, and reducing or preventing scar formation are provided..
Tarix Pharmaceuticals Ltd.


02/26/15
20150056217 

Use of toll-like receptor-9 agonists, toll-like receptor-4 antagonists, and/or nuclear oligomerization domain-2 agonists for the treatment or prevention of toll-like receptor-4 associated disorders


The present invention relates to the use of a tlr9 agonist and/or a tlr4 antagonist and/or a nod2 agonist for treatment or prevention of disorders involving tlr4 activation, such as systemic sepsis and necrotizing enterocolitis.. .
University Of Pittsburgh - Of The Commonwealth System Of Highter Education


02/26/15
20150056133 

Cx3cr1-targeting imaging agents and their use in the diagnosis and treatment of disease


The present invention relates to cx3cr1-targeting imaging agents and their use in treatment and diagnosis of diseases. Single domain cx3cr1-targeting polypeptides linked to detection labels and their use in in vivo imaging of atherosclerotic plaques are described.



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