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Roti-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Prevention of tumour metastasis by inhibition of necroptosis
Max-planck-gesellschaft Zur FÖrderung Der Wissenschaften E.v.
August 10, 2017 - N°20170226514

The present invention relates to an inhibitor of necroptosis for use in preventing the metastasis of tumours. Further, the present invention relates to a method of preventing the metastasis of tumours by inhibiting necroptosis and to a method for modulating the transmigration of metastasising tumour cells through endothelium by modulating necroptosis as well as to an in-vitro method of identifying ...
Methods for decreasing the incidence of necrotizing enterocolitis in infants, toddlers, or children using human ...
Abbott Laboratories
August 10, 2017 - N°20170224714

Disclosed are methods of reducing the incidence of necrotizing enterocolitis in an infant, toddler, or child using nutritional compositions including human milk oligosaccharides. The nutritional compositions including the human milk oligosaccharides are effective in reducing inflammation and the incidence of inflammatory diseases.
6-aryl amino pyridone formamide compound crystal and preparation method therefor
Centaurus Biopharma Co., Ltd.
August 03, 2017 - N°20170217979

The present invention provides a crystal of 6-arylamino pyridone carboxamide compound and a preparation method thereof. The crystal is obtained by dissolving 6-(2-chloro-4-iodophenylamino)-n-(2-hydroxylethyoxyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-carboxamide in an aprotic polar solvent and adding a second solvent thereto. The crystallization method has the advantage of simple and convenient operations, and is beneficial to ...
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Anti-pdgfr-beta antibodies and uses thereof
Regeneron Pharmaceuticals, Inc.
July 27, 2017 - N°20170210813

The present invention provides antibodies that bind to platelet derived growth factor receptor beta (pdgfr-beta) and methods of using the same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human pdgfr-beta with high affinity. The antibodies of the invention are useful for the treatment of diseases and disorders associated with pdgfr-beta signaling ...
Aplnr modulators and uses thereof
Regeneron Pharmaceuticals, Inc
July 27, 2017 - N°20170210800

The present invention provides apelin receptor (aplnr) modulators that bind to aplnr and methods of using the same. The invention includes aplnr modulators such as antibodies, or antigen-binding fragments thereof, which inhibit or attenuate aplnr-mediated signaling. The invention includes aplnr modulators such as antibodies, or antibody fusion proteins thereof, that activate aplnr-mediated signaling. According to certain embodiments of the invention, ...
Systems and methods for transcatheter aortic valve treatment
Silk Road Medical, Inc.
July 27, 2017 - N°20170209260

Devices and methods are configured to allow transcervical or subclavian access via the common carotid artery to the native aortic valve, and implantation of a prosthetic aortic valve into the heart. The devices and methods also provide means for embolic protection during such an endovascular aortic valve implantation procedure.
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Intravascular catheter having an expandable incising portion and grating tool
Silk Road Medical, Inc.
July 27, 2017 - N°20170209160

An intravascular device is provided having an expandable portion including a plurality of struts capable of being moved between an open and a closed position. A grating tool is provided on at least one of the struts. The grating tool is configured to remove atherosclerotic material or other substances located within the blood vessel when the expandable portion is in ...
Il-33 antagonists and uses thereof
Silk Road Medical, Inc.
July 20, 2017 - N°20170204158

The present invention provides interleukin-33 (il-33) antagonists comprising one or more il-33-binding domains and one or more multimerizing domains and methods of using the same. According to certain embodiments of the invention, the il-33-binding domains can comprise an il-33-binding portion of an st2 protein and/or an extracellular portion of an il-1racp protein. The il-33 antagonists ...
Method for isolating rna with high yield
Qiagen Gmbh
July 13, 2017 - N°20170198279

A phenol-free method for isolating a nucleic acid from a sample is provided, said method comprising the following steps: a) preparing a precipitation mixture by adding at least one metal cation precipitant and at least one organic solvent selected from aprotic polar solvents and protic solvents to the sample, wherein the precipitation mixture i) comprises the metal cation precipitant; ii) ...
Image-guided irrigating suction cannula for removal of intracerebral hemorrhage and other lesions
The Regents Of The University Of California
July 13, 2017 - N°20170197017

A minimally invasive surgery device for image-guided removal of lesions in the brain by providing suction and irrigation through a small cranial opening. One particular use is for evacuation of intracerebral hemorrhage. Other uses may include evacuation of pus from an abscess, or cystic fluid or necrotic debris from a tumor.
Compositions comprising granulocyte-macrophage colony-stimulating factor for the treatment of inflammatory bowel disease
Reponex Pharmaceuticals Aps
July 13, 2017 - N°20170196937

The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor and fosfomycin for the treatment, prevention or alleviation of an inflammatory bowel disease such as crohn's disease, ulcerative colitis or necrotizing enterocolitis of newborn and premature infants by administration of the compositions into the intestinal lumen.
Ppar compounds for use in the treatment of fibrotic diseases
Inventiva
July 06, 2017 - N°20170189383

The invention relates to the use of a pan-ppar agonist, or of a pharmaceutical composition containing said agonist, for the treatment of a fibrotic condition.
Method for inducing hypothermia in a patient
Neuron Guard S.r.l.
June 29, 2017 - N°20170181888

A therapeutic collar comprising an elongate body made from a flexible material for extending around at least a portion of the neck of a patient. The body has a length approximating the circumference of the neck, two thermoelectric devices for overlying two carotid arteries in the neck and two thermoelectric devices for overlying of two vertebral arteries in the neck ...
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Methods of delivering heparin binding epidermal growth factor using stem cell generated exosomes
Research Institute At Nationwide Children's Hospital
June 22, 2017 - N°20170173113

The invention provides for methods of delivering heparin binding epidermal growth factor (hb-egf) to sites of intestinal injury using stem cell derived exosomes in particular, the invention provides for methods of delivering hb-egf loaded stem cell-derived exosomes to sites of intestinal injury and methods of protecting a subject and method of treating intestinal injury, such as necrotizing enterocolitis (nec).
Apoptosis signal-regulating kinase inhibitors
Research Institute At Nationwide Children's Hospital
June 22, 2017 - N°20170173031

Wherein variables are as defined above. The compounds have apoptosis signal-regulating kinase (“ask1”) inhibitory activity, and are thus useful in the treatment of ask1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, copd, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver ...
Substituted spirocyclic inhibitors of autotaxin
X-rx, Inc.
June 15, 2017 - N°20170166568

The present invention relates to compounds according to formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by atx.
Carotid artery occluding apparatus with first and second occluding balloons
X-rx, Inc.
June 15, 2017 - N°20170165457

An apparatus for preventing stroke by occluding blood flow through a right carotid artery and a left carotid artery of a patient is provided. The apparatus has a first occluding catheter that carries a first occluding balloon that has an inflated configuration that occludes either the right carotid artery or the left carotid artery. The apparatus also includes a second ...
Compositions and methods for treating diabetes and liver diseases
Cempra Pharmaceuticals, Inc.
June 15, 2017 - N°20170165286

Compounds, compositions, and methods are described herein for treating diabetes, fatty liver diseases, fibrotic diseases, such as liver and pulmonary fibrosis, and hepatocellular carcinoma.
System and method for delivering protease inhibitors
Bordoloi Biotech, Llc
June 15, 2017 - N°20170165215

The disclosed invention provides a system and method of artificially retarding fibrin-based blood clot degradation via the sustained release of a protease inhibitor, such as, for example, aprotinin or tranexamic acid (“ta”). The sustained release of the protease inhibitor is accomplished through incorporation within a biodegradable polymer microsphere to produce a protease inhibitor formulation. Next, the ...
Cysteamine in the treatment of fibrotic disease
Seattle Children's Hospital (dba Seattle Children' S Research Institute)
June 15, 2017 - N°20170165207

Fibrotic diseases are characterized by the replacement of healthy tissue with scar tissue and extracellular matrix in response to tissue damage. Here we describe the reduction of extracellular matrix (ecm) deposition, interstitial fibroblasts, interstitial volume, expression of collagen i mrna and protein, expression of profibrotic cytokines and macrophage infiltration by cysteamine treatment.
Intravascular catheter having an expandable incising portion and abrasive surfaces
Seattle Children's Hospital (dba Seattle Children' S Research Institute)
June 08, 2017 - N°20170156749

An intravascular device is provided having a catheter tube and an expandable portion including a plurality of struts capable of being moved between an open and a closed position. An incising element and an abrasive surface are provided on at least one of the struts. The incising element has a sharpened edge for creating an incision in, and the abrasive ...
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