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Roti-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Heterocyclic derivatives as rorgamma modulators
Genfit
December 07, 2017 - N°20170349582

The present invention provides novel compounds of formula (i) that are modulators of rorgamma. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the modulation of rorgamma has therapeutic effects, for instance in autoimmune diseases, autoimmune-related diseases, inflammatory diseases, fibrotic diseases, or cholestatic diseases.
Novel aryl-cyanoguanidine compounds
Bayer Pharma Aktiengesellschaft
November 30, 2017 - N°20170342034

The present invention relates to protein-lysine n-methyltransferase smyd2 (set and mynd domain-containing protein 2) inhibitors, in particular smyd2-inhibitory substituted cyanoguanidine-pyrazolines of general formula (i) wherein r1, r2, r3, r4, r5, x and r have the meaning as described and defined herein, as well as to pharmaceutical compositions comprising compounds according to the invention and to their prophylactic and therapeutic use ...
Targeted contrast agents comprising a hydrazide functional group
Rf Therapeutics Inc.
November 30, 2017 - N°20170340757

Described herein is a contrast agent for administration to a subject. The contrast agent includes a targeting portion that includes a hydrazide functional group; a metal ion bound to a metal-complexable portion; and a linker joining the targeting portion and the metal-complexable portion of the contrast agent. The portion that is not bound to a metal ion localizes the contrast ...
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Compositions for treating pathological calcification conditions, and methods using same
Yale University
November 30, 2017 - N°20170340713

The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of generalized arterial calcification of infancy (gaci), idiopathic infantile arterial calcification (iiac), ossification of the posterior longitudinal ligament (opll), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, pxe, hereditary ...
Device for the transdermal delivery of rotigotine
Amarin Technologies S.a.
November 30, 2017 - N°20170340578

A transdermal delivery system (tds) for the transdermal administration of rotigotine, comprising an adhesive matrix layer, a backing film and release liner, wherein the adhesive matrix comprises rotigotine, an adhesive polymer and a copolymer of polyethylene glycol, polyvinyl caprolactam and polyvinyl acetate. Preferentially, the adhesive polymer is the block styrene-isoprene-styrene (sis).
Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
Ionis Pharmaceuticals, Inc.
November 23, 2017 - N°20170335329

This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.
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Probe for detecting atherosclerosis
The Board Of Trustees Of The Leland Stanford Junior University
November 16, 2017 - N°20170325697

A probe device for detecting atherosclerotic plaque may include: an elongate shaft having a proximal end for coupling with a catheter and a distal end; an opening in a side of the shaft; a scintillating window disposed over the opening to form a water tight seal and thus form an imaging window compartment; a 45-degree rotating mirror disposed at least ...
Cellular-based method for determining the biological activity of defibrotide
Gentium S.r.l.
November 09, 2017 - N°20170322199

The present invention relates to cell-based methods for determining the biological activity of defibrotide. In particular, the invention provides a method for assessing the potency of defibrotide by assessing the viability of mammalian cells in the presence of at least one cytotoxic agent and one or more concentrations of defibrotide. Such methods are particularly useful for standardizing pharmaceutical compositions comprising ...
Polyimide-based resin film cleaning liquid, method for cleaning polyimide-based resin film, method for producing polyimide ...
Tokyo Ohka Kogyo Co., Ltd.
November 09, 2017 - N°20170321168

A polyimide-based resin film cleaning liquid includes at least one solvent selected from the group consisting of a hydroxy aliphatic carboxylic acid ester, an aliphatic carboxylic acid ester, a chain or cyclic ketone, an alkylene glycol monoalkyl ether, an alkylene glycol monoalkyl ether acetate, and an aprotic polar solvent other than these solvents.
Pharmaceutical formulations of xanthine or xanthine derivatives, and their use
Imprimis Pharmaceuticals, Inc.
November 09, 2017 - N°20170319590

The present invention relates to pharmaceutical formulations comprising xanthine or xanthine derivatives, kits thereof, and methods for treating fibrotic diseases by local administration.
Methods of treating acute myeloid leukemia with antibodies to bone marrow stromal antigen 1
Imprimis Pharmaceuticals, Inc.
November 02, 2017 - N°20170313785

The invention provides antibodies which bind to the adp-ribosyl cyclase 2. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided. The antibodies may be used for the treatment of human cancers, including acute myeloid leukemia (aml), b-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung ...
Systems and methods for treating a carotid artery
Imprimis Pharmaceuticals, Inc.
November 02, 2017 - N°20170312491

Systems and methods are adapted for treating the carotid artery. The systems include interventional catheters and blood vessel access devices that are adapted for transcervical insertion into the carotid artery. Embodiments of the systems and methods can be used in combination with embolic protection systems including blood flow reversal mechanisms, arterial filters, and arterial occlusion devices.
Methods for producing stable therapeutic formulations in aprotic polar solvents
Imprimis Pharmaceuticals, Inc.
November 02, 2017 - N°20170312341

Certain embodiments are directed to a formulation of a therapeutic agent, as well as a method of making such a formulation, comprising at least one therapeutic agent dissolved in an aprotic polar solvent system comprising at least one ionization stabilizing excipient in a concentration sufficient to impart physical and chemical stability to the therapeutic agent.
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Modular endo-aortic device for endovascular aortic repair of dissections and being configured for adaptability of ...
Imprimis Pharmaceuticals, Inc.
November 02, 2017 - N°20170312103

A device for placement in the aortic arch of a patient is provided. The device includes a distal portion for being engageably received in an aortic arch of a patient beyond the left subclavian artery and a stent portion fluidly engaged with the distal portion, the stent portion being permeable and configured to span a portion of the aortic arches ...
Processes for the preparation of rotigotine and intermediates thereof
Apotex Inc.
October 26, 2017 - N°20170305877

The present invention provides processes for the preparation of a compound of formula 2 or a salt thereof, wherein r1 is selected from the group consisting of h, c1-c3 alkyl, and c(0)r3; r3 is selected from the group consisting of c1-c6 alkyl, c6-c10aryl and c7-c20 arylalkyl; the carbon atom marked with “*” ...
Defibrotide for use in prophylaxis and/or treatment of graft versus host disease (gvhd)
Gentium S.r.l.
October 26, 2017 - N°20170304349

Defibrotide for use in prophylaxis and/or treatment of graft versus host disease (gvhd) in humans is disclosed, preferably in hematopoietic stem cell transplantation (iisct), more preferably allogeneic hernatopoietic stein cell transplantation. Graft versus host disease oldie invention (gvhd) can be acute agvhd and/or chronic covhd, preferably acute.
Mobile medicine communication platform and methods and uses thereof
Gentium S.r.l.
October 19, 2017 - N°20170300654

Telemedicine systems and methods are described. In a telemedicine system operable to communicate with a remote operations center, communications can be transmitted/received using a transceiver having an antenna. The antenna can include first and second di-pole antenna elements, the first di-pole antenna element being vertically polarized and the second di-pole antenna element being horizontally polarized. A controller of the ...
Compositions and methods for treating hepatic fibrosis
Gentium S.r.l.
October 19, 2017 - N°20170298352

This disclosure provides pharmaceutical compositions and purified or isolated naturally occurring exosome products that have therapeutic use for treating an unmet medical need. The exosome compositions contain an effective amount of exosomes isolated from a body fluid of a non-diseased subject. The compositions are useful in the treatment of a variety of fibrotic diseases.
Methods and devices for transcarotid access
Gentium S.r.l.
October 19, 2017 - N°20170296798

A micropuncture kit for direct access of a surgically exposed vessel using direct visual guidance includes a micropuncture access needle having a proximal hub coupled to an elongate shaft defining an inner lumen and a visible depth indicator positioned on the elongate shaft a distance away from a distal tip of the elongate shaft. The kit includes an access guidewire ...
Lipid hydrolysis therapy for atherosclerosis and related diseases
Gentium S.r.l.
October 19, 2017 - N°20170296631

The present invention comprises a method to diminish and/or eliminate atherosclerotic plaques, in mammals, through direct and indirect treatment of these plaques, in situ, using suitable substances which are capable of lipid removal, primarily through hydrolysis, either by a catalytic or stoichiometric process, wherein the substance targets receptors in and/or on the cell which lead to uptake into ...
Prevention of atherosclerotic events with direct factor xa inhibitors
Gentium S.r.l.
October 19, 2017 - N°20170296549

The use of direct factor xa inhibitors, administered in a dose sufficient to reduce the activity of factor xa to about 25% less than normal or lower, has the effect of preventing the onset of atherosclerosis, and stabilizing atherosclerotic lesions, and preventing the occurrence or recurrence of atherosclerotic events.
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