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Roti-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Substituted spirocyclic inhibitors of autotaxin
X-rx, Inc.
June 15, 2017 - N°20170166568

The present invention relates to compounds according to formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by atx.
Carotid artery occluding apparatus with first and second occluding balloons
X-rx, Inc.
June 15, 2017 - N°20170165457

An apparatus for preventing stroke by occluding blood flow through a right carotid artery and a left carotid artery of a patient is provided. The apparatus has a first occluding catheter that carries a first occluding balloon that has an inflated configuration that occludes either the right carotid artery or the left carotid artery. The apparatus also includes a second ...
Compositions and methods for treating diabetes and liver diseases
Cempra Pharmaceuticals, Inc.
June 15, 2017 - N°20170165286

Compounds, compositions, and methods are described herein for treating diabetes, fatty liver diseases, fibrotic diseases, such as liver and pulmonary fibrosis, and hepatocellular carcinoma.
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Cysteamine in the treatment of fibrotic disease
Seattle Children's Hospital (dba Seattle Children' S Research Institute)
June 15, 2017 - N°20170165207

Fibrotic diseases are characterized by the replacement of healthy tissue with scar tissue and extracellular matrix in response to tissue damage. Here we describe the reduction of extracellular matrix (ecm) deposition, interstitial fibroblasts, interstitial volume, expression of collagen i mrna and protein, expression of profibrotic cytokines and macrophage infiltration by cysteamine treatment.
Intravascular catheter having an expandable incising portion and abrasive surfaces
Seattle Children's Hospital (dba Seattle Children' S Research Institute)
June 08, 2017 - N°20170156749

An intravascular device is provided having a catheter tube and an expandable portion including a plurality of struts capable of being moved between an open and a closed position. An incising element and an abrasive surface are provided on at least one of the struts. The incising element has a sharpened edge for creating an incision in, and the abrasive ...
Estimation and display for vector doppler imaging using plane wave transmissions
Verasonics, Inc.
June 08, 2017 - N°20170156704

Vector doppler imaging (vdi) improves on conventional color doppler imaging (cdi) by giving speed and direction of blood flow at each pixel of a display generated by a computing system. Multiple angles of plane wave transmissions (pwt) via an ultrasound transducer conveniently give projected doppler measurements over a wide field of view, providing enough angular diversity to identify velocity vectors ...
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Lipid hydrolysis therapy for atherosclerosis and related diseases
Children's Hospital Medical Center
June 01, 2017 - N°20170151313

The present invention comprises a method to diminish and/or eliminate atherosclerotic plaques, in mammals, through direct and indirect treatment of these plaques, in situ, using suitable substances which are capable of lipid removal, primarily through hydrolysis, either by a catalytic or stoichiometric process, wherein the substance targets receptors in and/or on the cell which lead to uptake into ...
Use of rotigotine for treating the restless leg syndrome
Ucb Pharma Gmbh
June 01, 2017 - N°20170151215

This invention relates to the use of rotigotine for the effective treatment of restless leg syndrome (rls) as well as to a rotigotine-containing transepicutaneous pharmaceutical composition, provided in particular in the form of an acrylate- or silicone-based transdermal therapeutic system (us) having a surface area of 2. 5 to 20 cm2 and containing 0. 1 to 3. 15 mg/cm2 rotigotine as its active component against the ...
Diazepane derivatives and uses thereof
Ucb Pharma Gmbh
May 25, 2017 - N°20170145023

The present disclosure provides compounds of formula (i), and pharmaceutically compositions thereof. Compounds of formula (i) have been found to bind bromodomains and/or bromodomain-containing proteins (e. G., bromo and extra terminal (bet) proteins). Also provided are methods, uses, and kits of the compounds and pharmaceutical compositions for inhibiting the activity (e. G., increased activity) of bromodomains and/or bromodomain-containing ...
Dihydropteridinone derivatives and uses thereof
Ucb Pharma Gmbh
May 25, 2017 - N°20170145013

The present disclosure provides compounds of formula (i), and pharmaceutically compositions thereof. Compounds of formula (i) have been found to bind bromodomains and/or bromodomain-containing proteins (e. G., bromo and extra terminal (bet) proteins). Also provided are methods, uses, and kits of the compounds and pharmaceutical compositions for inhibiting the activity (e. G., increased activity) of bromodomains and/or bromodomain-containing ...
Improved atherectomy device
Ucb Pharma Gmbh
May 25, 2017 - N°20170143372

An atherectomy device comprising a rotatably motor-driven flexible hollow shaft that is coaxial with a longitudinal axis of the guidewire; an annular distal end of the hollow shaft having a diameter that is only slightly larger than the diameter of the guidewire and configured with cutting surfaces for piercing hardened atherosclerotic plaque! A tubular sleeve secured to a first peripheral ...
Transcarotid neurovascular catheter
Silk Road Medical, Inc.
May 18, 2017 - N°20170136212

An interventional catheter for treating an artery includes an elongated body sized and shaped to be transcervically introduced into a common carotid artery at an access location in the neck. The elongated body has an overall length such that the distal most section can be positioned in an intracranial artery and at least a portion of the proximal most section ...
Acetylcholinesterase inhibitors for treatment of dermatological conditions
Attillaps Holdings
May 18, 2017 - N°20170135978

Embodiments of the invention involve treating skin afflictions by the topical or oral use of acetylcholinesterase inhibitor. By effectively reducing or eliminating the population of demodex mites in affected skin areas and areas where demodex mites may exist, this treatment achieves a more complete remission of clinical signs and symptoms of the skin afflictions than any previously described method. Embodiments ...
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System and method for measuring artery thickness using ultrasound imaging
Arizona Board Of Regents On Behalf Of Arizona State University
May 04, 2017 - N°20170124701

A system and method for automating the selection of end-diastolic ultrasound frames (eufs] and regions of interest (rois] of the common carotid artery (cca] to measure the carotid intima-media thickness (cimt] is provided. The eufs are selected based on the qrs complex of the ecg signal associated with an ultrasound video, and the roi is detected based on image intensity ...
Peptides having effects on promoting wound healing, collagen production, angiogenesis, activation of immunocytes and applications ...
Tci Co., Ltd
May 04, 2017 - N°20170121378

The present invention provides 11 peptides represented as seq id no: 1-11. The peptides have the ability of anti-virus and bacteria, and can reduce infections, clean necrotic tissue, and promote debridement so as to facilitate wound healing. Moreover, the peptides can also induce collagen secretion and activate fibroblasts and keratinocytes so as to stimulate angiogenesis. Thus, the peptides of the present ...
Bet-protein inhibiting 3,4-dihydropyrido[2,3-b]pyrazinones with meta-substituted aromatic amino- or ether groups
Tci Co., Ltd
May 04, 2017 - N°20170121322

Furthermore, this invention relates to the use of bet protein inhibitors in viral infections, in neurodegenerative disorders, in inflammatory diseases, in atherosclerotic disorders and in male fertility control.
Dendrimer compositions and use in treatment of necrotizing enterocolitis and other gastrointestinal disorders
The Johns Hopkins University
May 04, 2017 - N°20170119897

A dendrimer formulation, such as a pamam dendrimer or a multiarm peg polymeric formulation has been developed for oral administration to the gastrointestinal tract for treatment of inflammatory diseases associated with infection or cancer. In the preferred embodiment, the dendrimers are in the form of dendrimer nanoparticles comprising poly(amidoamine) (pamam) hydroxyl-terminated dendrimers covalently linked to at least one therapeutic, ...
Apparatus and method for stabilization of procedural catheter in tortuous vessels
The Johns Hopkins University
May 04, 2017 - N°20170119563

The use of bifurcated catheter is disclosed for stabilizing working catheters for carotid percutaneous intervention of vessels originating from a tortuous aortic arch, which uses guide wires that used to enable the catheters accessing the left or right carotid arteries (ca). Also disclosed is the use of two independent catheters or a catheter and snare wire within a single sheath, ...
Apparatus and method for a bifurcated catheter for use in hostile aortic arches
The Johns Hopkins University
May 04, 2017 - N°20170119562

Systems and methods for addressing the percutaneous intervention related trauma to the vessels that arise from type-iii hostile aortic arches, from uncontrolled prolapse of sheaths, embolic protection devices and stent delivery systems, by stabilizing the systems while stenting of the left and right carotid arteries. Guide wires to stabilize catheters used to access the left or right carotid arteries (ca) ...
Method for the attenuation of atherosclerosis condition(s) using licorice extract as a medicament
The Johns Hopkins University
April 27, 2017 - N°20170112887

The present invention is a method for the attenuation treatment of atherosclerosis condition(s), as manifested by the reduction of the carotid intima-media thickness (cimt). The attenuation treatment is based on consuming an effective amount of a medicament comprising licorice extract which is water insoluble and free from glycyrrhizinc acid on a daily basis for a period of at least ...
System and method for plaque serration
Cagent Vascular, Llc
April 20, 2017 - N°20170106174

A device and method for intravascular treatment of atherosclerotic plaque prior to balloon angioplasty which microperforates the plaque with small sharp spikes acting as serrations for forming cleavage lines or planes in the plaque. The spikes may also be used to transport medication into the plaque. The plaque preparation treatment enables subsequent angioplasty to be performed at low balloon pressures ...
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