Follow us on Twitter
twitter icon@FreshPatents


Roti patents

      

This page is updated frequently with new Roti-related patent applications.




 Evaluation of carotid plaque using contrast enhanced ultrasonic imaging patent thumbnailEvaluation of carotid plaque using contrast enhanced ultrasonic imaging
An ultrasound system and method are described for acquiring a sequence of ultrasound images of the carotid artery during the delivery of a contrast agent. Plaque in the images is identified and a time-intensity curve is calculated for pixels in the images.
Koninklijke Philips N.v.


 Method of destroying tissue cells by electroporation patent thumbnailMethod of destroying tissue cells by electroporation
An apparatus and method for performing non-invasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical contact with the patient's skin for applying the pulses to the patient's skin.
Angiodynamics, Inc.


 Methods and devices for cryogenic carotid body ablation patent thumbnailMethods and devices for cryogenic carotid body ablation
Methods and cryogenic devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via carotid body ablation. Some methods include advancing a cryo-ablation catheter into a patient's vasculature and ablating tissue within a carotid septum..

 Carotid septum ablation with ultrasound imaging and ablation catheters patent thumbnailCarotid septum ablation with ultrasound imaging and ablation catheters
Methods and devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via carotid body ablation.. .

 Diaminopyrimidine benzenesulfone derivatives and uses thereof patent thumbnailDiaminopyrimidine benzenesulfone derivatives and uses thereof
The present invention provides compounds of formula (ii) (e.g., compounds of formula (i)), and pharmaceutically compositions thereof. Compounds of formula (ii) are believed to be binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (bet) proteins).
Dana-farber Cancer Institute, Inc.


 Methods, devices and systems for carotid body ablation via a transradial or transbrachial approach patent thumbnailMethods, devices and systems for carotid body ablation via a transradial or transbrachial approach
Described herein are methods and endovascular catheters, configured for delivery to a carotid artery from a subclavian artery approach, for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via carotid body ablation.. .
Cibiem, Inc.


 Identification and treatment of vulnerable plaques patent thumbnailIdentification and treatment of vulnerable plaques
A method of detecting an atherosclerotic plaque vulnerable to rupture in a subject comprises providing to the subject a labelled necrostatin or a derivative thereof, and visualizing the label, wherein a localization of the label in a plaque indicates the plaque is vulnerable to rupture. A method of detecting and treating an atherosclerotic plaque vulnerable to rupture comprises providing to the subject a labelled necrostatin or a derivative thereof, visualizing the label, wherein a localization of the label in a plaque indicates the plaque is vulnerable to rupture; and providing a necroptosis inhibitor or derivative thereof to the subject when the visualizing indicates that the plaque is vulnerable to rupture.
Ottawa Heart Institute Research Corporation


 Endovascular catheters and methods for carotid body ablation patent thumbnailEndovascular catheters and methods for carotid body ablation
Systems, devices, and methods for treating a patient having a sympathetically mediated disease associated at least in part with augmented peripheral chemoreflex or heightened sympathetic activation. The treatments include ablating one or more peripheral chemoreceptors or associated afferent nerves to reduce or remove afferent neural signals from the peripheral chemoreceptor..

 Intravascular device patent thumbnailIntravascular device
An intravascular device can comprise a carrier and an expansion apparatus. The device can be used for intravascular treatment of atherosclerotic plaque.
Cagent Vascular, Llc


 Apoptosis signal-regulating kinase inhibitors patent thumbnailApoptosis signal-regulating kinase inhibitors
The present application relates to compounds having the inhibitory activity to apoptosis signal-regulating kinase (ask1), thus are thus useful in treating ask1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, copd, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver diseases, and neurodegenerative diseases.. .
Gilead Sciences, Inc.


Use of neuregulin-4 for treatment of inflammatory bowel disease and necrotizing enterocolitis

The invention provides methods, pharmaceutical compositions and kits for treating, inhibiting and/or reducing the severity of inflammatory bowel disease and necrotizing enterocolitis in a subject in need thereof by administering an effective amount of a composition comprising an activator of erbb4.. .
Children's Hospital Los Angeles

Systems and methods for transcatheter aortic valve treatment

Devices and methods are configured to allow transcarotid or subclavian access via the common carotid artery to the native aortic valve, and implantation of a prosthetic aortic valve into the heart. The devices and methods also provide means for embolic protection during such an endovascular aortic valve implantation procedure..
Silk Road Medical, Inc.

Embolic deflection device

There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (such as greater than 100 microns) from entering either the right or left common carotid arteries, and/or the right or left vertebral arteries by deflecting emboli downstream of these vessels.
Edwards Lifesciences Corporation

Use of a sweet whey containing infant formula for promoting the postnatal neuronal development of the infant gastrointestinal tract, and the establishment of the intestinal functions that it controls

The present invention relates to administration of sweet whey protein (swp) for promoting the enteric neuronal development in infants, especially preterm, low birth, very low and extremely low birth weight infants as well as in young children up until the age of six. Administration of the swp according to the invention prevents and treats disorders associated with an immature or impaired enteric nervous system.
Nestec S.a.

Intravascular catheter having an expandable incising portion and embolic protection device

An intravascular device is provided having a catheter tube and an expandable portion including a plurality of struts capable of being moved between an open and a closed position. An incising element is provided on at least one of the struts and has a sharpened edge for creating an incision in atherosclerotic material located within a blood vessel when the expandable portion is in the opened position.

Detection of atherosclerotic cardiovascular disease risk

Methods are disclosed herein for determining the likelihood that a subject will develop atherosclerotic cardiovascular disease (ascvd) or a myocardial infarction (mi). Methods are also disclosed for determining if a pharmaceutical agent is effective for the treatment or prevention of ascvd.
Trustees Of Boston University

Inhibitors of cellular necrosis and related methods

Or a pharmaceutically acceptable salt, prodrug, stereoisomer or tautomer thereof, is provided. Related compounds, methods for preparation of the same and uses of the compounds for treatment of various indications, including treatment of necrotic cell diseases and/or inflammation, are also provided..

Method for producing 2-furaldehyde

An object of the present invention is to provide a method for suppressing the corrosion of a reactor and reducing waste in the production of 2-furaldehyde from a sugar raw material containing a hexose as a constituent component, and another object of the invention is to provide an industrially advantageous method for producing 2-furaldehyde, which suppresses a decrease in the activity of a catalyst in a case of using an acid catalyst and provides a higher yield. The present invention relates to a method for producing 2-furaldehyde comprising heating a sugar raw material containing a hexose as a constituent component in an aprotic polar solvent in the presence of a solid acid catalyst..
Mitsubishi Chemical Corporation

Carotid artery blood filter plugging alarm

An intravascular filter device having a flexible arm which comprises a portion of an alarm system for detecting filling or plugging of the filter by captured emboli is described. The flexible arm may be made of ferromagnetic material, a magnet, or have at its tip a magnet which, as it moves under systolic and diastolic pressures, generates a signal detectable by an electrical sensor or a magnetometer.
Cook Medical Technologies Llc

Methods and systems for establishing retrograde carotid arterial blood flow

Devices and methods establish and facilitate retrograde or reverse flow blood circulation in the region of the carotid artery bifurcation in order to limit or prevent the release of emboli into the cerebral vasculature such as into the internal carotid artery. The methods are particularly useful for interventional procedures performed through a transcarotid approach or transfemoral into the common carotid artery..
Silk Road Medical, Inc.

Compositions for use in the prevention or treatment of necrotizing enterocolitis in infants or young children born by c-section

The present invention relates to a composition comprising at least one human milk oligosaccharide and/or a precursor thereof, for use in preventing and/or treating necrotizing enterocolitis in infants or young children born by c-section.. .
Nestec S.a.

Compositions for use in the prevention or treatment of necrotizing enterocolitis in infants and young children

The invention discloses a composition comprising lnt and at least another human milk oligosaccharide or precursor thereof, for use in preventing and/or treating necrotizing enterocolitis in infants and young children.. .
Nestec S.a.

Compositions for use in the prevention or treatment of necrotizing enterocolitis in infants and young children

The invention discloses a composition comprising an oligosaccharide mixture, said oligosaccharide mixture comprising from 40 to 80 wt % of fucosylated oligosaccharide(s), from 10 to 50 wt % of n-acetylated oligosaccharide(s), from 5 to 40 wt % of sialylated oligosaccharide(s) and from 0 to 20 wt % of precursor(s) of human milk oligosaccharide, for use in preventing and/or in treating necrotizing enterocolitis in infants and young children.. .
Nestec S.a.

Substituted pyridazines for the treatment of pain

The compounds are useful as pharmaceuticals, particularly in the treatment of fibrotic diseases, cancer and pain.. .

Methods for reversing fibrosis

The present invention provides methods of reversing the activation of hepatic stellate cells using astaxanthin (astx), or a pharmaceutically acceptable salt thereof, for use in the reversal of fibrosis and fibrotic diseases.. .
The University Of Connecticut

Biochemical markers for cvd risk assessment

Provided is a method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque such as lumican, versican, perlecan, deocrin, biglycan, collagen type iii, crp, apoe, or elastin by a proteinase. The method comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of the immunological binding partner to peptide fragments in the sample.
Nordic Bioscience A/s

Modulation of timp1 and timp2 expression

Provided herein are compositions, methods and kits for modulating expression of target genes, particularly of tissue inhibitor of metalloproteinase 1 and of tissue inhibitor of metalloproteinase 2 (timp1 and timp2, respectively). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (sina), short interfering rna (sirna), double-stranded rna (dsrna), micro-rna (mirna) or short hairpin rna (shrna)) that modulate a gene encoding timp1 and timp2, for example, the gene encoding human timp1 and timp2.
Nitto Denko Corporation

Substituted dihydropyrido[3,4-b]pyrazinones as dual inhibitors of bet proteins and polo-like kinases

Furthermore, the present invention relates to the use of the dihydropyrido[3,4-b]pyrazinones according to the invention in viral infections, in neurodegenerative disorders, in inflammation disorders, in atherosclerotic disorders and in male fertility control.. .

Methods and systems for establishing retrograde carotid arterial blood flow

Interventional procedures on the carotid arteries are performed through a transcervical access while retrograde blood flow is established from the internal carotid artery to a venous or external location. A system for use in accessing and treating a carotid artery includes an arterial access device, a shunt fluidly connected to the arterial access device, and a flow control assembly coupled to the shunt and adapted to regulate blood flow through the shunt between at least a first blood flow state and at least a second blood flow state.
Silk Road Medical, Inc.

Method and treating a carotid artery

One disclosed embodiment comprises a method for treating lesions in the carotid artery of a mammalian body. The method comprises transcervical access and blocking of blood flow through the common carotid artery (with or without blocking of blood flow through the external carotid artery), shunting blood from the internal carotid artery and treating the lesion in the carotid artery..
Silk Road Medical, Inc.

Vascular occluding bridged self-expanding metal stent (vobsems)

This patent application is for the design of a vascular occluding bridged self-expanding metal stent (vobsems) for fixed and immobile selective vascular occlusion and thrombosis of arteries and veins. Current vascular self-expanding metal stents (sems) are designed to open atherosclerotic arteries such as coronary arteries.

Methods of treatment

The present disclosure provides a biochemical basis of nephrotic syndrome and provides and explanation for the observed proteinuria and other effects. As a result, the present disclosure provides method for treating and/or preventing nephrotic syndrome as well as methods of alleviating symptoms associated with nephrotic syndrome.

Composition preventing necrotic enteritis in galloanserans

The present invention refers to the use of a glycerol ester composition of at least one short chain fatty acid for preventing and/or alleviating necrotic enteritis in the gastric tract of galloanserans. The glycerol ester composition comprises at least 75% by weight of glyceryl tributyrate, below 25% by weight of glyceryl dibutyrate and below 8% by weight of glyceryl monobutyrate.
Perstorp Ab

Aspiration maximizing catheter

A catheter design and method is provided for the aspiration of thrombus, clot, atherosclerotic emboli in the vascular bed. The aspiration catheter includes an aspiration lumen, a guidewire lumen having an exchange port, and a recess in the aspiration unit.
Creganna-tactx Medical

The present invention provides cyclic compounds that are useful in preventing or treating atherosclerosis or related disorders. The invention also provides therapeutic methods for treating or preventing various diseases or disorders associated with or mediated by atherosclerosis.
The Scripps Research Institute

Antioxidant compound having anti atherosclerotic effect and preparation thereof

The present invention relates to an antioxidant compound having anti atherosclerotic effect and preparation thereof. The present invention more particularly relates to the synthesis of tpp+ coupled esculetin (mitochondria-targeted esculetin [mito-esc]) followed by the biological evaluation of mito-esc for its ability to attenuate angiotensin-ii-induced atherosclerosis in apolipoproteine knockout (apoe−/−) mice along with the endothelial cell age-delaying effects of mito-esc..
Council Of Scientific And Industrial Research

Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders

Wherein r1a, r1b, r2, r4, r5, r6a, r6b, r7, r8, w, x, cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (npp2 or enpp2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, and/or abnormal angiogenesis associated diseases by administering the compound of the invention..

Substituted 3-haloallylamine inhibitors of ssao and uses thereof

The invention also relates to methods of using compounds of formula i, or pharmaceutically acceptable salt or derivatives thereof, for the treatment of a variety of indications, e.g., inflammatory diseases, ocular diseases, fibrotic diseases, diabetes-induced diseases and cancer.. .

Methods and systems for disrupting calcified walls of biological conduits and calcified lesions therein

The present system is directed in various embodiments to rotational atherectomy systems and methods generally. More specifically, a method for methodically softening and otherwise disrupting calcification located within atherosclerotic plaque, lesion or occlusion and/or within the wall of a biological conduit or lumen.
Cardiovascular Systems, Inc.

Suture delivery device

A suture-based vessel closure device is configured to close a carotid artery puncture site. The suture-based vessel closure device can place one or more sutures across the vessel access site such that, when the suture ends are tied off after sheath removal, the stitch or stitches provide hem ostasis to the access site.
Silk Road Medical, Inc.

Heterocyclic substituted trifluoromethyl pyrimidinones and their use

The present application relates to novel heterocyclically substituted 6-(trifluoromethyl)pyrimidin-4(3h)-one derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular, renal, inflammatory and fibrotic diseases.. .
Bayer Pharma Aktiengesellschaft

Mineralized collagen-based femoral head support device

A femoral head support device, in particular a mineralized collagen-based femoral head support device applicable to the treatment of early osteonecrosis of femoral head. The device is made from a dense, homogeneous organic/inorganic composite, wherein the organic phase includes collagen and inorganic phase includes nano calcium phosphate salt, and the device is of a cylinder having an upright through hole and also has a support strength of up to 4000-6000n.

Reconstituted high density lipoproteins composition and uses thereof

A reconstituted high density lipoprotein composition including negatively charged phospholipids enhances cholesterol clearance, reduces inflammation and other anti-atherosclerotic actions.. .
Universite Pierre Et Marie Curie - Paris 6 (upmc)

System and delivery of a protease inhibitor

The disclosed invention provides a system and method of artificially retarding fibrin-based blood clot degradation via the sustained release of a protease inhibitor, such as, for example, aprotinin or tranexamic acid (“ta”). The sustained release of the protease inhibitor is accomplished through incorporation within a biodegradable polymer microsphere to produce a protease inhibitor formulation.
Bordoloi Biotech, Llc

Agent for preventing or ameliorating renal dysfunction

An object of the present invention is to provide an agent for preventing or ameliorating renal dysfunction, excellent in the inhibitory action on the advance of renal dysfunction, the suppressive action on renal fibrosis, the suppressive action on the development of renal failure, and the suppressive action on nephritis. The administration of an agent for preventing or ameliorating renal dysfunction, containing lubiprostone or its pharmacologically acceptable salt as an active ingredient by a method, such as oral administration, can inhibit the advance of renal dysfunction, suppress renal fibrosis, suppress the development of renal failure, and suppress nephritis, and thus can prevent or ameliorate nephritides, such as acute glomerulonephritis, minimal change nephritis, chronic glomerulonephritis, renal sclerosis, membrane proliferative nephritis, mesangial proliferative glomerulonephritis, membrane proliferative glomerulonephritis, crescentic nephritis, rapidly progressive glomerulonephritis, membranous glomerulonephritis, tubulointerstitial nephritis, acute pyelonephritis, chronic pyelonephritis, endocapillary proliferative nephritis, and lupus nephritis; renal failures, such as acute renal failure and chronic renal failure; and renal dysfunctions, such as amyloid kidney, membranous nephropathy, focal glomerulosclerosis, iga nephropathy, acute tubular necrosis, nephrotic syndrome, diabetic nephropathy, gouty kidney, renal edema, renal tumors, renal ischemic disorders, and renal ischemia-reperfusion injury..
Tohoku University

Prevention of tissue ischemia and related methods

Provided herein are compositions for preventing, ameliorating, and/or reducing tissue ischemia and/or tissue damage due to ischemia, increasing blood vessel diameter, blood flow and tissue perfusion in the presence of vascular disease including peripheral vascular disease, atherosclerotic vascular disease, coronary artery disease, stroke and influencing other conditions, by suppressing cd47 and/or blocking tsp1 and/or cd47 activity or interaction. Influencing the interaction of cd47-tsp1 in blood vessels allows for control of blood vessel diameter and blood flow, and permits modification of blood pressure and cardiac function.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv

Disubstituted trifluoromethyl pyrimidinones and their use

The present application relates to novel 2,5-disubstituted 6-(trifluoromethyl)pyrimidin-4(3h)-one derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular, renal, inflammatory and fibrotic diseases.. .
Bayer Pharma Aktiengesellschaft

Method for setting elastic threads in ligation device and automatic elastic thread ligation device

The present invention provides a method for setting elastic threads in a ligation device and an automatic elastic thread ligation device using the method. At least one elastic thread (2) is arranged along the outer wall of a barrel (3) of the ligation device, and an annular sleeve (21) with an adjustable aperture and formed at the front end of the elastic thread (2) is sleeved on the outer wall of the front end of the barrel; a traction thread (26) on the ligation device is connected with the annular sleeve (21) of the elastic thread (2), and when the traction thread (26) is pulled, the traction thread drives the annular sleeve (21) to move towards the orifice of the barrel (3), until the annular sleeve is disengaged from the orifice; a force bearing part of the annular sleeve (21) at the front end of the elastic thread is propped forwards, meanwhile, the tail end of the elastic thread (2) is pulled backwards, and the countertraction between the two acting forces leads to a gradual decrease of the aperture of the annular sleeve (21) at the front end of the elastic thread (2).

Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders

Wherein r1a, r1b, r2, r4, r5, r6, r7, r8, w, x, y, z, cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (npp2 or enpp2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, and/or abnormal angiogenesis associated diseases by administering the compound of the invention..

Aprotinin-derived polypeptide-antibody conjugates

The present invention relates to protein conjugates comprising an aprotinin-derived polypeptide, which facilitates transport of the conjugate across the blood-brain barrier, and an antibody moiety that selectively binds a target within the cns. The protein conjugates are further defined by the inclusion of a linker; by the number of polypeptides conjugated to each antibody moiety; by the positions at which the antibody moiety and the polypeptides are conjugated; and by the larger configuration of the conjugate (in which every polypeptide is linked only to the antibody moiety).
Angiochem Inc.

Feed additive composition

A method for improving the performance of a subject or for improving digestibility of a raw material in a feed (e.g. Nutrient digestibility, such as amino acid digestibility), or for improving nitrogen retention, or for improving dietary phosphorus absorption and retention, or for improving the efficacy of the phytase, or for improving the subject's resistance to necrotic enteritis or for improving feed conversion ratio (fcr) or for improving weight gain in a subject or for improving feed efficiency in a subject or for modulating (e.g.
Dupont Nutrition Biosciences Aps

Devices and techniques for vascular compression

The present disclosure provides for specific shapes and combinations of the compression members amenable to the safest, yet most effective compression of the carotid and vertebral arteries aimed at prevention of embolic stroke. An associated method of achieving an optimal compression of said arteries for the purpose of stroke prevention is provided..

Methods and compositions for reducing cardiac damage and other conditions

Endoglin has been identified to play a functional role as a regulator of tgfβ1 signaling, particular in tgfβ1-mediated calcineurin expression. The present invention features methods of reducing cardiac damage, particularly in a subject undergoing chemotherapy or radiation therapy by administering a composition that inhibits endoglin activity.
Tufts Medical Center, Inc.

Antimicrobial composition comprising pyrogenic silica and serrathopeptidase and uses thereof

Methods are provided for treatment of wounds using a complex antimicrobial sorption composition possessing the necrolytic effect for treating the purulent wounds, the trophic ulcers, the wounds, and the infiltrates with the significant necrotic and exudative components represents the silica sorbent with the immobilized drug. Pyrogenic silica is used as a siliceous sorbent, and serrathiopeptidase as a drug..
Willingsford Limited

Treatments for fibrotic diseases

Disclosed herein are methods for treatment for fibrosis, ocular pathologies associated with fibrosis, including proliferative vitreoretinopathy (pvr) by inhibiting the activity of activated transforming growth factor β activated kinase 1 (tak1), or activation thereof. Pharmaceutical compositions for use in the described treatments are also provided..
Mor Research Applications Ltd.

Blood based biomarkers for diagnosing atherosclerotic coronary artery disease

The invention, in some aspects, relates to methods for evaluating a human subject for having atherosclerotic coronary artery disease (ascad) or as having a coronary atherosclerotic plaque. In some aspects, the invention relates to methods and kits useful for diagnosing, classifying, profiling and treating atherosclerotic cad and or a coronary atherosclerotic plaque..
Global Genomics Group, Llc

Fusion protein comprising albumin and retinol-binding protein

There is provided a fusion protein comprising albumin and retinol-binding protein (rbp), which can be used for preventing or treating fibrotic diseases. The fusion protein, in which albumin and rbp are bound together, is incorporated into stellate cells and induces phenotypic reversion from myofibroblast-like cells to quiescent fat-storing phenotype.
Korea University Research And Business Foundation

Three-layer transdermal therapy system (tts)

The invention relates to an at least three-layer transdermal therapy system (tts), which contains, in particular, rotigotine as an active ingredient. The tts comprises an active ingredient-containing central layer, which comprises at least one hygroscopic polymer or copolymer, an inner, active ingredient-permeable layer and an outer layer..
Tesa Labtec Gmbh

Methods and apparatuses for treating auto-immune diseases by ablative neuromodulation

The present invention, in some embodiments thereof, relates to intravascular neural ablation and, more particularly, but not exclusively, to tools and methodologies for treating systemic nerve hyperactivity through splenic and/or carotid denervation. Devices are disclosed for performing ablation and protecting a patient from formation of embolisms.
La Vita Technologies Ltd.

Intravascular catheter balloon device having a tool for atherectomy or an incising portion for atheromatous plaque scoring

An apparatus and method is disclosed for an intravascular balloon device having a balloon and a handle where a catheter tube extends between the two. The handle assembly includes an inflation device in fluid communication with the balloon.

Bone removal under direct visualization

An approach to removing necrotic bone under direct visualization is provided. To remove bone and to watch it being removed at the same time, one example uses an endoscope and bone removal tool assembled together by a sheath.
Smith & Nephew, Inc.

Modulation of efferocytosis pathways for treatment of atherosclerotic disease

Smooth muscle cells (smc) from subjects carrying at least one 9p21 risk factor, can be resistant to efferocytosis, leading to the retention of such cells in the necrotic core of atherosclerotic plaque. In the methods of the invention, an agent that increases efferocytosis of cellular components of coronary plaque, including efferocytosis of apoptotic smooth muscle cells, is administered to the subject in a dose and for a period of time effective to stabilize, prevent or reduce atherosclerotic plaque in the individual..
The Board Of Trustees Of The Leland Stanford Junior University

Bet-protein-inhibiting dihydropyridopyrazinones

This invention further relates to the use of bet protein inhibitors in viral infections, in neurodegenerative disorders, in inflammation diseases, in atherosclerotic disorders and in male fertility control.. .

N-alkoxyamide conjugates as imaging agents

The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided.

Treatment of x-linked hypohidrotic ectodermal dysplasia with a fusion eda1 protein

The invention relates to methods for the temporal administration of eda agonists, in particular edi200, which correlate to optimal therapeutic response windows required for the formation of any eda-dependent structures such as ectodermal appendages. Use of the methods described allow for the design of targeted therapeutic dosing and administration regimens in order to correct or alter abnormal phenotypes associated with genetic disorders, in particular, xlhed..

Modified bet-protein-inhibiting dihydroquinoxalinones and dihydropyridopyrazinones

This invention further relates to the use of bet protein inhibitors in viral infections, in neurodegenerative disorders, in inflammation diseases, in atherosclerotic disorders and in male fertility control.. .

Inhibitors of cellular necrosis and related methods

Or a pharmaceutically acceptable salt, prodrug, stereoisomer or tautomer thereof, is provided. Related compounds, methods for preparation of the same and uses of the compounds for treatment of various indications, including treatment of necrotic cell diseases and/or inflammation, are also provided..

Transcarotid neurovascular catheter

An interventional catheter for treating an artery includes an elongated body sized and shaped to be transcervically introduced into a common carotid artery at an access location in the neck. The elongated body has an overall length such that the distal most section can be positioned in an intracranial artery and at least a portion of the proximal most section is positioned in the common carotid artery during use..
Silk Road Medical, Inc.

Treatment of fibrotic diseases

The present invention relates to rspo and lgr antagonists, and methods of using the rspo and lgr antagonists for treating or preventing fibrotic diseases.. .
Oncomed Pharmaceuticals, Inc.





Follow us on Twitter
twitter icon@FreshPatents

###

This listing is a sample listing of patent applications related to Roti for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Roti with additional patents listed. Browse our RSS directory or Search for other possible listings.


1.4225

file did exist - 5113

0 - 1 - 101