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Rna Polymerase

Rna Polymerase-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Rna polymerase i inhibitors and uses thereof
Tel Hashomer Medical Research Infrastructure And Services, Ltd.
October 12, 2017 - N°20170290842

Provided are novel compounds which are capable of inhibiting an activity of rna polymerase i, and uses thereof in treating diseases or disorders modulated by rna polymerase i, preferably autoimmune diseases such as multiple sclerosis and proliferative diseases.
Compositions and methods relating to synthetic rna polynucleotides created from synthetic dna oligonucleotides
New England Biolabs, Inc.
October 05, 2017 - N°20170283797

Compositions and methods are provided for forming a single rna polynucleotide from a plurality of dna oligonucleotides in a single reaction chamber using combined reagents in a single step reaction. Dna polymerase, rna polymerase and single stranded (ss) dna oligonucleotides are combined where each dna oligonucleotide has one or more sequence modules, wherein one sequence module in the first ss ...
Antiviral azasugar-containing nucleosides
Biocryst Pharmaceuticals, Inc.
September 21, 2017 - N°20170267681

Disclosed are compounds comprising an azasugar attached to a heterocyclic base, including pharmaceutically acceptable salts thereof, suitable for use in inhibiting viral rna polymerase activity or viral replication, and treating viral infections. The compounds are characterized, in part, by favorable pharmacokinetics for the active pharmaceutical ingredient, particularly in conjunction with enteral administration, including, in particular, oral administration. Also disclosed are ...
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Thermostable variants of t7 rna polymerase
New England Biolabs, Inc.
August 31, 2017 - N°20170247670

A bacteriophage rna polymerase variant is provided. In some embodiments, the variant may have increased thermostability relative to the corresponding wild type bacteriophage rna polymerase and/or wild type t7 rna polymerase. Compositions, kits and methods that employ the variant are also provided.
Compositions and methods to treating hemoglobinopathies
Children's Medical Center Corporation
August 03, 2017 - N°20170218372

Embodiment herein provide specially designed synthetic bcl11a-targeting micrornas for rna polymerase ii expression, and methods o use to treat hemoglobinopathies such as sickle cell disease or thalassemia by increasing the expression levels of fetal hemoglobin levels. In particular illustrative embodiment, the present invention provides, in part, improved compositions and methods for achieving gene therapy in hematopoietic cells and hematopoietic ...
T7 rna polymerase variants with expanded substrate range and enhanced transcriptional yield
The Board Of Regents Of The University Of Texas System
July 27, 2017 - N°20170211050

Disclosed are t7 rna polymerase variants with enhanced transcriptional activity. T7 rna polymerase variants are known which have the ability to incorporate modified ribonucleotides into growing rna molecules. However, these variants have relatively low levels of transcriptional activity. Presented herein are mutations that increase the transcriptional activity of the variants with broad substrate range.
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Nucleoside derivatives as inhibitors of rna-dependent rna viral polyermase
Ionis Pharmaceuticals, Inc.
June 29, 2017 - N°20170183373

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of rna-dependent rna viral polymerase. These compounds are inhibitors of rna-dependent rna viral replication and are useful for the treatment of rna-dependent rna viral infection. They are particularly useful as inhibitors of hepatitis c virus (hcv) ns5b polymerase, as inhibitors of hcv replication, and/or for ...
Antibacterial agents: salinamide derivatives
Ionis Pharmaceuticals, Inc.
June 15, 2017 - N°20170166611

And salts thereof, wherein x and y have any of the values defined herein. The compounds inhibit bacterial rna polymerase, inhibit bacterial growth, and have applications in, analysis of rna polymerase structure and function, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, antibacterial therapy, and drug discovery.
T7 expression system, method for its production and use thereof for producing recombinant proteins
Wacker Chemie Ag
June 01, 2017 - N°20170152491

The invention relates to an expression system comprising a prokaryotic cell which contains a polynucleotide construct that encodes a t7 rna polymerase under the control of a t7 promoter and under the control of an inducible promoter. The invention also relates to an expression vector which contains a gene that encodes a protein to be expressed under the control of ...
Systems and methods for synthetic biology design and host cell simulation
Wacker Chemie Ag
May 25, 2017 - N°20170147742

Systems and methods are proposed for synthetic biology design and host cell simulation. In one form, a synthetic biology design system is proposed, comprising a model conversion component configured to: receive genetic circuit data indicative of a user-specified genetic circuit design; identify, from the genetic circuit data, constituent parts of the genetic circuit design, and the connections between the constituent ...
Dna templates for small rna production in mammalian cells
Research Foundation Of The City University Of New York
May 18, 2017 - N°20170137859

This disclosure describes unique single stranded dna templates having a characteristic sequence and secondary structure. The dna templates disclosed herein are useful for making small rna molecules through promoter-independent transcription by a mammalian rna polymerase, and can serve as an effective vector for producing small rna molecules of interest in vitro, in situ and in vivo in mammalian cells.
Compositions and methods for inhibiting viral polymerase
Research Foundation Of The City University Of New York
May 11, 2017 - N°20170128454

As described herein. Compounds of formula i are useful in methods of inhibiting viral rna polymerase activity and viral replication. Also provided are pharmaceutical compositions comprising compounds of formula i, as well as methods of treating viral infections using compounds of formula i.
Small molecule inhibitors of influenza a rna-dependent rna polymerase
Nant Holdings Ip, Llc
May 11, 2017 - N°20170128450

Antiviral compositions and methods are contemplated that are especially effective in the treatment and prevention of influenza a viruses. Also presented are cellular assays to identify small molecule compounds having antiviral properties, particularly as it relates to detection of influenza a rna-dependent rna polymerase activity in a mammalian cell independent of other influenza a components. Preferred assays allow for identification ...
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Phosphonates with reduced toxicity for treatment of viral infections
The Regents Of The University Of California
April 06, 2017 - N°20170096441

There are provided, inter alia, acyclic nucleoside phosphonate compounds having reduced toxicity and enhanced antiviral activity, and pharmaceutically accepted salts and solvates thereof. There are also provided methods of using the disclosed compounds for inhibiting viral rna-dependent rna polymerase, inhibiting viral reverse transcriptase, inhibiting replication of virus, including hepatitis c virus or a human retrovirus, and treating a subject infected ...
Vectors and methods for fungal genome engineering by crispr-cas9
Bp Corporation North America Inc.
March 30, 2017 - N°20170088845

The present disclosure provides expression vectors containing a nucleic acid encoding an rna polymerase iii promoter, a ribozyme, a crispr-cas9 single guide rna, and an rna polymerase iii terminator, where the ribozyme is 5′ to the crispr-cas9 single guide rna, as well as ribonucleic acids encoded thereby. Further provided are fungal cells containing an expression vector described herein, as well ...
Compounds which inhibit rna polymerase, compositions including such compounds, and their use
Lieber Institute For Brain Development
March 23, 2017 - N°20170081322

Rna polymerase i (pol i) is a dedicated polymerase for the transcription of the 47s ribosomal rna precursor subsequently processed into the mature 5. 8s, 18s and 28s ribosomal rnas and assembled into ribosomes in the nucleolus. Pol i activity is commonly deregulated in human cancers. Based on the discovery of lead molecule bmh-21, a series of pyridoquinazolinecarboxamides were synthesized as ...
Bipartite inhibitors of bacterial rna polymerase
Lieber Institute For Brain Development
March 02, 2017 - N°20170056512

Wherein x is an moiety that binds to the rifamycin binding site of a bacterial rna polymerase, y is a moiety that binds to the ge23077 binding site of a bacterial rna polymerase, and α is a linker. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention ...
Two plasmid mammalian expression system
Lieber Institute For Brain Development
February 02, 2017 - N°20170029786

Reverse engineering has offered new ways of studying the pathology of rna viral infections, new more efficient devices of synthesizing recombinant viruses and developing vaccines and also demonstrated the versatility and efficiency of rna dependent rna polymerase rdrp system as an expression system. However, the currently used methods require a repertoire of complex, difficult-to-use tools. Present invention describes, a simpler ...
Microorganism with improved l-threonine producing capability, and method for producing l-threonine by using the same
Cj Cheiljedang Corporation
December 22, 2016 - N°20160369310

The present invention relates to a novel variant rna polymerase sigma factor 70 (π70) polypeptide, a polynucleotide encoding the same, a microorganism containing the polypeptide, and a method for producing l-threonine by using the microorganism.
Rna polymerase, methods of purification and methods of use
President And Fellows Of Harvard College
December 22, 2016 - N°20160369248

Cyanophage syn5 rna polymerase (rnap) and methods of purifying it are provided. Cyanophage syn5 rnap having one or more promoter mutations are provided. Methods of expressing cyanophage syn5 rnap are provided. Novel promoter sequences and in vitro transcription systems utilizing syn5 rnap are provided. Methods of making high range ssrna ladders are also provided. Methods of incorporating 2′-modified dntps ...
Rna polymerase ii33 nucleic acid molecules to control insect pests
Fraunhofer-gesellschaft Zur Förderung Der Angewandten Forschung E.v.
December 08, 2016 - N°20160355841

This disclosure concerns nucleic acid molecules and methods of use thereof for control of insect pests through rna interference-mediated inhibition of target coding and transcribed non-coding sequences in insect pests, including coleopteran and/or hemipteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of insect pests, and the plant ...
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