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Rna Polymerase

Rna Polymerase-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Influenza a 2009 pandemic h1n1 polypeptide fragments comprising endonuclease activity and their use
European Molecular Biology Laboratory (embl)
February 15, 2018 - N°20180044649

The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the pa subunit of a viral rna-dependent rna polymerase possessing endonuclease activity, wherein said pa subunit is from influenza a 2009 pandemic h1n1 virus or is a variant thereof. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said ...
Microorganism with enhanced l-lysine producibility and method for producing l-lysine using the same
Cj Cheiljedang Corporation
February 08, 2018 - N°20180037615

The present disclosure relates to a novel modified rna polymerase sigma factor a (siga) polypeptide; a polynucleotide encoding the same; a microorganism containing the polypeptide; and a method for producing l-lysine using the microorganism.. .
Highly productive one-pot system for the incorporation of non-standard amino acids into cell-free synthesized proteins
Northwestern University
January 18, 2018 - N°20180016614

Disclosed are methods, systems, components, and compositions related to genomically recoded and engineered organisms. The disclosed genomically recoded and engineered organisms may be used to prepare extracts for use in platforms and methods for preparing sequence defined biopolymers in vitro.
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Gene expression system using stealthy rna, and gene introduction/expression vector including said rna
Tokiwa-bio Inc.
December 28, 2017 - N°20170369903

Simultaneous expression of a plurality of foreign genes by using a stealthy rna gene expression system that is a complex that does not activate the innate immune mechanism and is formed from an rna-dependent rna polymerase, a single-strand rna binding protein, and negative-sense single-strand rnas including the following (1) to (8): (1) a target rna sequence that codes for any protein or functional ...
Methods of predicting clinical course and treating multiple sclerosis
Tel Hashomer Medical Research Infrastructure And Services Ltd.
December 21, 2017 - N°20170362657

Provided are methods and kits for classifying a subject as being more likely to have benign multiple sclerosis (bms) or as being more likely to have typical relapsing remitting multiple sclerosis (rrms). Classification of multiple sclerosis disease course is performed by comparing a level of expression of at least one gene involved in the rna polymerase i pathway in a ...
Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase
December 14, 2017 - N°20170355731

The invention disclosed herein relates to cytotoxic cyclic peptides of formula (i), methods of inhibiting rna polymerase with such cyclic peptides, immunoconjugates comprising such cyclic peptides (i.e antibody drug conjugates), pharmaceutical compositions comprising such cyclic peptides immunoconjugates, compositions comprising such cyclic peptides immunoconjugates with a therapeutic co-agent and methods of treatment using such cyclic peptides immunoconjugates:. .
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Compositions and methods relating to synthetic rna polynucleotides created from synthetic dna oligonucleotides
New England Biolabs, Inc.
October 05, 2017 - N°20170283797

Compositions and methods are provided for forming a single rna polynucleotide from a plurality of dna oligonucleotides in a single reaction chamber using combined reagents in a single step reaction. Dna polymerase, rna polymerase and single stranded (ss) dna oligonucleotides are combined where each dna oligonucleotide has one or more sequence modules, wherein one sequence module in the first ss ...
Antiviral azasugar-containing nucleosides
Biocryst Pharmaceuticals, Inc.
September 21, 2017 - N°20170267681

Disclosed are compounds comprising an azasugar attached to a heterocyclic base, including pharmaceutically acceptable salts thereof, suitable for use in inhibiting viral rna polymerase activity or viral replication, and treating viral infections. The compounds are characterized, in part, by favorable pharmacokinetics for the active pharmaceutical ingredient, particularly in conjunction with enteral administration, including, in particular, oral administration.
Inhibitors for steroid response elements and rna polymerase ii and related methods
September 14, 2017 - N°20170260169

The present invention relates to polyamides capable of inhibiting are-, gre- and ere-mediated gene regulation in cells. The present invention also relates to polyamides capable of modulating the activity of rna polymerase ii and p53.
Thermostable variants of t7 rna polymerase
New England Biolabs, Inc.
August 31, 2017 - N°20170247670

A bacteriophage rna polymerase variant is provided. In some embodiments, the variant may have increased thermostability relative to the corresponding wild type bacteriophage rna polymerase and/or wild type t7 rna polymerase.
Compositions and methods to treating hemoglobinopathies
Children's Medical Center Corporation
August 03, 2017 - N°20170218372

Embodiment herein provide specially designed synthetic bcl11a-targeting micrornas for rna polymerase ii expression, and methods o use to treat hemoglobinopathies such as sickle cell disease or thalassemia by increasing the expression levels of fetal hemoglobin levels. In particular illustrative embodiment, the present invention provides, in part, improved compositions and methods for achieving gene therapy in hematopoietic cells and hematopoietic ...
T7 rna polymerase variants with expanded substrate range and enhanced transcriptional yield
The Board Of Regents Of The University Of Texas System
July 27, 2017 - N°20170211050

Disclosed are t7 rna polymerase variants with enhanced transcriptional activity. T7 rna polymerase variants are known which have the ability to incorporate modified ribonucleotides into growing rna molecules.
Methods and kits for cell-free transcription and translation
Technion Research & Development Foundation Limited
July 13, 2017 - N°20170198326

A method for cell-free protein synthesis, the method comprising synthesizing rna or a protein of interest in a reaction mixture comprising: a template dna encoding the rna or protein of interest; and a biological extract of a protease-deficient bacterial cell that has been genetically modified to express a heterologous rna polymerase, the extract further comprising components necessary for transcription and ...
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Antibacterial agents: salinamide derivatives
June 15, 2017 - N°20170166611

And salts thereof, wherein x and y have any of the values defined herein. The compounds inhibit bacterial rna polymerase, inhibit bacterial growth, and have applications in, analysis of rna polymerase structure and function, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, antibacterial therapy, and drug discovery..
T7 expression system, method for its production and use thereof for producing recombinant proteins
Wacker Chemie Ag
June 01, 2017 - N°20170152491

The invention relates to an expression system comprising a prokaryotic cell which contains a polynucleotide construct that encodes a t7 rna polymerase under the control of a t7 promoter and under the control of an inducible promoter. The invention also relates to an expression vector which contains a gene that encodes a protein to be expressed under the control of ...
Systems and methods for synthetic biology design and host cell simulation
May 25, 2017 - N°20170147742

Systems and methods are proposed for synthetic biology design and host cell simulation. In one form, a synthetic biology design system is proposed, comprising a model conversion component configured to: receive genetic circuit data indicative of a user-specified genetic circuit design; identify, from the genetic circuit data, constituent parts of the genetic circuit design, and the connections between the constituent ...
Dna templates for small rna production in mammalian cells
Research Foundation Of The City University Of New York
May 18, 2017 - N°20170137859

This disclosure describes unique single stranded dna templates having a characteristic sequence and secondary structure. The dna templates disclosed herein are useful for making small rna molecules through promoter-independent transcription by a mammalian rna polymerase, and can serve as an effective vector for producing small rna molecules of interest in vitro, in situ and in vivo in mammalian cells..
Compositions and methods for inhibiting viral polymerase
May 11, 2017 - N°20170128454

As described herein. Compounds of formula i are useful in methods of inhibiting viral rna polymerase activity and viral replication.
Small molecule inhibitors of influenza a rna-dependent rna polymerase
Nant Holdings Ip, Llc
May 11, 2017 - N°20170128450

Antiviral compositions and methods are contemplated that are especially effective in the treatment and prevention of influenza a viruses. Also presented are cellular assays to identify small molecule compounds having antiviral properties, particularly as it relates to detection of influenza a rna-dependent rna polymerase activity in a mammalian cell independent of other influenza a components.
Methods and means for enhancing rna production
Curevac Ag
April 27, 2017 - N°20170114378

The present invention relates to a method for synthesizing an rna molecule of a given sequence, comprising the step of determining the fraction (1) for each of the four nucleotides g, a, c and u in said rna molecule, and the step of synthesizing said rna molecule by in vitro transcription in a sequence-optimized reaction mix, wherein said sequence-optimized reaction mix ...
Phosphonates with reduced toxicity for treatment of viral infections
The Regents Of The University Of California
April 06, 2017 - N°20170096441

There are provided, inter alia, acyclic nucleoside phosphonate compounds having reduced toxicity and enhanced antiviral activity, and pharmaceutically accepted salts and solvates thereof. There are also provided methods of using the disclosed compounds for inhibiting viral rna-dependent rna polymerase, inhibiting viral reverse transcriptase, inhibiting replication of virus, including hepatitis c virus or a human retrovirus, and treating a subject infected ...
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