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Remifentanil patents

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 Method of operating a control device for controlling an infusion device patent thumbnailMethod of operating a control device for controlling an infusion device
Method of operating a control device for controlling an infusion device a method of operating a control device (2) for controlling an infusion device (33) for administering a drug to a patient (p) comprises the steps of: providing a model (p) to predict a time-dependent drug concentration (cplasma, clung, cbrain) in multiple compartments (a1-a5) of a patient (p); setting a target concentration value (ctbrain) to be achieved in at least one of the compartments (a1-a5) of the patient (p); determining a drug dosage (d1) to be administered to a first compartment (a1) of the multiple compartments (al-a5) of the patient (p) using the model (p) such that the difference between the target concentration value (ctbrain) and a predicted steady-state drug concentration (cplasma, clung, cbrain) in the at least one of the compartments (a1-a5) is smaller than a pre-defined threshold value (ub-rain); providing a control signal (s1) indicative of the drug dosage (d1) to an infusion device (33) for administering the drug dosage (d1) to the patient (p); obtaining a measurement value (m1, m2) indicating a measured drug concentration in a second compartment (a2, a3) of the multiple compartments (a1-a5) at a measurement time (t1, t2); adjusting the model (p) such that the model (p) predicts a drug concentration (clung, cbrain) in the second compartment (a2, a3) at the measurement time (t1, t2) which at least approximately matches the measured drug concentration in the second compartment (a2, a3); and determining a new drug dosage (d2, d3) to be administered into the first compartment (al) of the patient (p) using the model (p) such that the difference between the target concentration value (ct-brain) and a predicted steady-state drug concentration (cplasma, clung, cbrain) in the at least one of the compartments (a1, a2, a3) is smaller than the predefined threshold value (ubrain). In this way a method is provided which allows for an improved (personalized and predictive) control of a drug administration procedure, in particular when administering an anaesthetic drug such as propofol and/or an analgesic drug such as remifentanil within a procedure..
Fresenius Kabi Deutschland Gmbh


 Xenon-based anesthetic gas composition usable during an endarterectomy involving the clamping of the carotid artery patent thumbnailXenon-based anesthetic gas composition usable during an endarterectomy involving the clamping of the carotid artery
A xenon-based anesthetic gas to be used, via inhalation, to maintain or preserve cerebral perfusion during an endarterectomy involving the clamping of the carotid artery in a mammal under general anesthesia. The xenon is preferably used in combination with at least one injectable anesthetic morphine agent such as remifentanil, sulfentanil, fentanyl, and alfentanil.
Air Liquide Santé (international)


 Stable liquid remifentanil formulations patent thumbnailStable liquid remifentanil formulations
A stable, non-aqueous, liquid pharmaceutical composition contains remifentanil dissolved in a non-aqueous solvent. The formulation is provided with a ph ranging from about 2.0 to about 3.5 and can be used as an injectable.

 Xenon-based anesthetic gas composition usable during an endarterectomy involving the clamping of the carotid artery patent thumbnailXenon-based anesthetic gas composition usable during an endarterectomy involving the clamping of the carotid artery
The invention relates to a xenon-based anesthetic gas composition to be used, via inhalation, to maintain or preserve cerebral perfusion during an endarterectomy involving the clamping of the carotid artery in a mammal under general anesthesia. The xenon is preferably used in combination with at least one injectable anesthetic morphine agent such as remifentanil, sulfentanil, fentanyl, and alfentanil.





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This listing is a sample listing of patent applications related to Remifentanil for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Remifentanil with additional patents listed. Browse our RSS directory or Search for other possible listings.


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