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Recombination

Recombination-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Thermo-electrically pumped light-emitting diodes
October 12, 2017 - N°20170294551

Contrary to conventional wisdom, which holds that light-emitting diodes (leds) should be cooled to increase efficiency, the leds disclosed herein are heated to increase efficiency. Heating an led operating at low forward bias voltage (e. G., v<kbt/q) can be accomplished by injecting phonons generated by non-radiative recombination back into the led's semiconductor lattice. This raises the ...
Active layer structure, semiconductor light emitting element, and display apparatus
Sony Corporation
October 05, 2017 - N°20170288090

[solving means] a semiconductor light emitting element includes a first conductive layer, a second conductive layer, and an active layer provided between the first conductive layer and the second conductive layer. The first conductive layer has a current constriction structure, a current injection region being constricted in the current constriction structure. The active layer includes a plurality of quantum well ...
Direct drive led driver and offline charge pump and method therefor
Sony Corporation
October 05, 2017 - N°20170286336

In a second embodiment an offline charge pump utilizes a switching matrix to recombine capacitors in accordance with the voltage on the ac half wave and then in accordance with a desired output voltage to feed a load, such that said recombinations occur at a frequency much higher than the frequency of the ac rectified half wave such that charge ...
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Process, apparatus, controller and system for producing petroleum products
Res Polyflow
October 05, 2017 - N°20170283706

A process and an apparatus for pyrolysis of mixed plastic feedstock producing petroleum products are described. In one example, a process for producing petroleum products includes charging feedstock of mixed polymer materials into a reactor apparatus. Heat energy is applied to the feedstock while advancing the feedstock through the reactor apparatus in an anaerobic operation. The energy input to the ...
Dominant mutation in the tdm gene leading to diplogametes production in plants
Institut National De La Recherche Agronomique
October 05, 2017 - N°20170280645

The invention relates to a dominant mutation in the tdm gene leading to the production of 2n gametes in plants, to the plants comprising said mutation, and to their use in plant breeding. The invention relates also to plants in which the dominant mutation in the tdm gene is combined with the inactivation of a gene involved in meiotic recombination ...
Dna knock-in system
Biocytogen, Llc
September 28, 2017 - N°20170273284

The present disclosure relates to an efficient genome editing technique. In one aspect, the technique can greatly improve the efficiency of homologous recombination during intracellular targeting, including gene targeting. Using this technique, genetically modified cell lines, rat, mouse, zebrafish, and fertilized eggs of other species can be quickly and efficiently generated.
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Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
Inserm (institut National De La Sante Et De La Recherche Medicale)
September 14, 2017 - N°20170260588

The invention relates to methods for detecting inactivation of the dna homologous recombination pathway in a patient, and in particular for detecting brca1 inactivation.
Compositions and methods for modifying cells
Regeneron Pharmaceuticals, Inc.
September 14, 2017 - N°20170260544

A method for engineering and utilizing large dna vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large dna targeting vectors for eukaryotic cells, termed ltvecs, are derived from fragments of cloned genomic dna larger than those typically used by other approaches intended to perform homologous targeting in ...
Substrate processing apparatus
Tokyo Electron Limited
September 07, 2017 - N°20170256382

A substrate processing apparatus, for generating a plasma from a gas by a high frequency energy and etching a substrate in a processing chamber by radicals in the plasma, includes a high frequency power supply configured to supply the high frequency energy into the processing chamber, a gas supply source configured to introduce the gas into the processing chamber, a ...
Dividing of reporter proteins by dna sequences and its application in site specific recombination
Tokyo Electron Limited
September 07, 2017 - N°20170253938

Methods and constructs for inserting an intron into a reporter protein coding sequence in a eukaryotic cell and their application of monitoring and reporting genomic modifications are provided. Various related compositions, cells and kits are also provided.
Method for producing a recombinant protein on a manufacturing scale
Sandoz Ag
September 07, 2017 - N°20170253900

A method for producing a protein of interest on a manufacturing scale is based on integration, by homologous recombination, of the dna encoding the protein of interest into a bacterial cell's genome at a pre-selected site. The manufacturing scale production of recombinant proteins is in the fed-batch mode, semi-continuous or in a chemostat.
Human monoclonal antibodies against cd25
Genmab A/s
August 24, 2017 - N°20170240640

Isolated human monoclonal antibodies which bind to and inhibit human cd25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e. G., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing v-d-j recombination and isotype switching. Also disclosed are ...
Autologous hiv-1 proteins for the treatment of latent hiv-1 infection
Case Western Reserve University
August 24, 2017 - N°20170239325

A method of reducing a latent hiv-specific memory-cd4+ t cell pool in a subject includes the steps of: preparing at least one hiv-1 protein coding sequence from a sample obtained from the subject, wherein the sample includes hiv-1 rna; introducing the at least one hiv-1 protein coding sequence into at least one expression construct using yeast homologous recombination; transfecting a ...
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Vertical thyristor memory with minority carrier lifetime reduction
Kilopass Technology, Inc.
August 10, 2017 - N°20170229306

Apparatus and methods for reducing minority carriers in a memory array are described herein. Minority carriers diffuse between on cells and off cells, causing disturbances during write operation as well as reducing the retention lifetime of the cells. Minority carrier lifetime killer (mclk) region architectures are described for vertical thyristor memory arrays with insulation trenches. These mclk regions encourage recombination ...
Versatile genetic assembly system (vegas) to assemble pathways for expression
Johns Hopkins University
August 10, 2017 - N°20170226532

Provided are compositions and methods for use in assembling and expressing a plurality of transcription units using, in one aspect, homologous recombination in yeast. Yeast containing the plurality of transcription units, and isolated transcription units, are also provided. Kits for use in making the yeast and the transcript units are further included.
Transgenic chickens with an inactivated endogenous gene locus
Alexion Pharmaceuticals, Inc.
August 10, 2017 - N°20170223938

The present invention is transgenic chickens obtained from long-term cultures of avian pgcs and techniques to produce and transgenic birds derived from prolonged pgc cultures. In some embodiments, these pgcs can be transfected with genetic constructs to modify the dna of the pgc, specifically to introduce a transgene encoding an exogenous protein. When combined with a host avian embryo by ...
Method of adaptive filtering of multiple seismic reflections
Ifp Energies Nouvelles
August 03, 2017 - N°20170219734

The invention is a method for processing seismic data to eliminate the coherent noise arising from multiple seismic reflections. A decomposition procedure is applied to decompose along n directions of decomposition seismic data into a set of n components. At least one model of multiple reflections is decomposed according to the same decomposition procedure and along the same n directions. ...
Method for producing polyhydroxyalkanoate copolymer from saccharide raw material
Kaneka Corporation
August 03, 2017 - N°20170218411

The purpose of the present invention is to provide a method for enhancing the production quantity of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (p(3hb-co-3hh)) having a high fraction of 3-hydroxyhexanoate (3hh) using a saccharide or glycerol as a starting material. The present invention provides: a method for producing a p(3hb-co-3hh) copolymer including performing transformation by homologous recombination of a ...
Stable genomic integration of multiple polynucleotide copies
Novozymes A/s
August 03, 2017 - N°20170218381

Methods of constructing a cell comprising in its chromosome one or more copies of an open reading frame (orf) or operon encoding at least one polypeptide of interest, each copy being under the transcriptional control of a heterologous promoter using a site specific recombinase and in vivo integration by recombination; resulting cells, and methods for producing a polypeptide of interest ...
Vector comprising multiple homologous nucleotide sequences
Bavarian Nordic A/s
July 27, 2017 - N°20170211098

The invention relates to vectors comprising two or more homologous nucleotide sequences and methods for generating them. The invention concerns substituting bases in the homologous nucleotide sequences with different bases that do not alter the encoded amino acid sequence. The invention allows for the reduction of intramolecular recombination between homologous nucleotide sequences, in particular in mammalian cells. The invention further ...
Fungal artificial chromosomes, compositions, methods and uses therfor
Intact Genomics
July 27, 2017 - N°20170211077

Fungal artificial chromosome (fac) vectors are disclosed. A vector can be replicated in a bacterial or a fungal host, and can comprise an insert of heterologous dna up to about 500 kilobases. A vector can be used for cloning and expressing a secondary metabolite (sm) gene cluster. An insert sequence can be modified by homologous recombination. A vector can be a ...
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