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Recombination

Recombination-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Nested feed-forward optical equalization using an electro-optic modulator with a multi-segment electrode
International Business Machines Corporation
December 07, 2017 - N°20170353333

A method and system of optical communication are provided. An optical modulator device includes a first and a second waveguide segment, and is configured to modulate an incident optical signal. A first feed-forward equalization (ffe) circuit including an inner first tap and an inner second tap, is configured to equalize the first waveguide segment. A second ffe circuit including a ...
Organic electroluminescent device
Tsinghua University
December 07, 2017 - N°20170352813

The present invention discloses an organic electroluminescence device, comprising a luminescent layer, wherein, a host material of the luminescent layer comprises a thermally activated delayed fluorescence material, the host material is doped by a dye, and the dye comprises at least one phosphorescent dye. The present invention employs a thermally activated delayed fluorescence material, whose difference between the triplet state ...
Methods of producing recombinant minicircle constructs
Plasmidfactory Gmbh Co & Kg
November 30, 2017 - N°20170342424

The present invention relates to a method for the production of a minicircle. In the method of the present invention, a parent plasmid is provided which has a nucleic sequence flanked by recombination sites. This parent plasmid is exposed to an enzyme which causes recombination at the recombination sites, thereby to form a (i) minicircle comprising the nucleic acid sequence ...
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Photoactivatable caged tamoxifen and tamoxifen derivative molecules and methods of use thereof
The General Hospital Corporation
November 30, 2017 - N°20170340736

Provided herein are compositions containing photoactivatable caged tamoxifen and tamoxifen derivative molecules. Also provided are kits containing one of these compositions and a light source. Also provided are methods of optically inducing nuclear translocation of a fusion protein containing a mammalian estrogen receptor ligand binding domain in a eukaryotic cell and methods of optically inducing recombination in a eukaryotic cell ...
Hco32 and hco27 and related examples
E.r. Squibb & Sons , L.l.c.
November 30, 2017 - N°20170339929

The instant invention relates to transgenic non-human animals capable of producing heterologous antibodies, transgenes used to produce such transgenic animals, transgenes capable of functionally rearranging a heterologous d gene in v-d-j recombination, immortalized b-cells capable of producing heterologous antibodies, methods and transgenes for producing heterologous antibodies of multiple isotypes, methods and transgenes for producing heterologous antibodies wherein a variable region ...
Dna cloaking technologies
Massachusetts Institute Of Technology
November 23, 2017 - N°20170335334

The disclosure relates to the use of steganographic methods to camouflage information encoded on nucleic acids. Specifically, the method comprising preparing a pool of recombinant nucleic acid constructs, wherein at least one of the constnjcts comprises the nucleic acid sequence to be camouflaged and wherein the pool is heterogeneous with respect to the orientation of the nucleic acid sequence to ...
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Trench process and structure for backside contact solar cells with polysilicon doped regions
Sunpower Corporation
November 16, 2017 - N°20170330988

A solar cell includes polysilicon p-type and n-type doped regions on a backside of a substrate, such as a silicon wafer. A trench structure separates the p-type doped region from the n-type doped region. Each of the p-type and n-type doped regions may be formed over a thin dielectric layer. The trench structure may include a textured surface for increased ...
Estimation of admixture generation
23andme, Inc.
November 16, 2017 - N°20170329902

Admixture generation determination includes: obtaining ancestry assignment information associated with an individual's genotype data, the ancestry assignment information at least indicating that a portion of the individual's genotype data is deemed to be associated with a specific ancestry; determining the individual's genetic ancestry summary data corresponding to the specific ancestry; estimating an admixture generation associated with the specific ancestry, the ...
Mutants of the bacteriophage lambda integrase
Agency For Science, Technology And Research
November 16, 2017 - N°20170327847

The present invention refers to lambda integrases comprising at least one amino acid mutation at positions 43, 319 and 336 of the lambda integrase as set forth in seq id no: 1. The invention further refers to nucleic acid molecules comprising the nucleotide sequence encoding the mutant lambda integrase and to host cells containing these nucleic acid molecules. The invention also refers to methods ...
Methods and compositions for targeted cleavage and recombination
Agency For Science, Technology And Research
November 16, 2017 - N°20170326174

Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted ...
Recombinase polymerase amplification
Alere San Diego Inc.
November 09, 2017 - N°20170321262

This disclosure describes related novel methods for recombinase-polymerase amplification (rpa) of a target dna that exploit the properties of recombinase and related proteins, to invade double-stranded dna with single stranded homologous dna permitting sequence specific priming of dna polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes, thus offering easy and affordable implementation and ...
Solid-state lighting source with integrated electronic modulator
Alere San Diego Inc.
November 02, 2017 - N°20170318632

A solid-state light source (ssls) with an integrated electronic modulator is described. A device can include a ssls having an active p-n junction region is formed within the ssls for electron-hole pair recombination and light emission. The active p-n junction region can include a n-type semiconductor layer, a p-type semiconductor layer and a light generating structure formed there between. A ...
Ambipolar synaptic devices
Alere San Diego Inc.
November 02, 2017 - N°20170317304

Device architectures based on trapping and de-trapping holes or electrons and/or recombination of both types of carriers are obtained by carrier trapping either in near-interface deep ambipolar states or in quantum wells/dots, either serving as ambipolar traps in semiconductor layers or in gate dielectric/barrier layers. In either case, the potential barrier for trapping is small and retention ...
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Signal via positioning in a multi-layer circuit board using a genetic via placement solver
Alere San Diego Inc.
November 02, 2017 - N°20170316139

One aspect includes identifying via groups that each includes a ratio of a plurality of signal vias to one ground via based on a design file defining a layout of a multi-layer circuit board. A genetic via placement solver iteratively evaluates potential placement solutions that adjust a placement of one or more of the signal vias until at least one ...
Cavity enhanced polarimeter and related methods
Alere San Diego Inc.
November 02, 2017 - N°20170315050

A polarimeter for measuring chirality of a material comprising an optical ring cavity comprising a plurality of reflective elements configured to promote bi-directional propagation of a laser beam within the cavity, a laser-emitting device configured to introduce a first input beam and a second input beam into the cavity, a faraday rotator, a phase compensator, an acousto-optic modulator configured to ...
Controlled thin-film ferroelectric polymer corona polarizing system and process
Areesys Technologies, Inc.
October 26, 2017 - N°20170310087

A corona polarization (also denoted “poling”) process and associated apparatus polarizes a ferroelectric polymer thin film while monitoring and evaluating a substrate current whose magnitude, slope and noise profile (barkhausen noise) varies in accordance with phase transformation processes of crystallites within the film and, thereby, provides an indication of the polarization status. The electric current flowing ...
Mems-based calorimeter, fabrication, and use thereof
The Trustees Of Columbia University In The City Of New York
October 26, 2017 - N°20170307553

A mems-based calorimeter includes a reference channel, a sample channel, and a thermopile configured to measure a temperature differential between the reference channel and a sample channel. The reference channel and the sample channel each include a passive mixer such as a splitting-and-recombination micromixer. The passive mixer can be formed by a first set of channels in a first layer ...
Protein with recombinase activity for site-specific dna-recombination
Technische Universität Dresden
October 26, 2017 - N°20170306356

The invention relates to the use of a protein with recombinase activity to catalyze a site-specific dna recombination and a method for producing a site-specific dna recombination. The invention is applicable alone or in combination with other recombinase systems for genetic manipulation, for example in medical research. The objective of the invention is solved by the use of a protein ...
Method for selecting polynucleotides encoding antigen-specific immunoglobulin subunit
Vaccinex, Inc.
October 26, 2017 - N°20170306318

The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy and light chain libraries, particularly using the trimolecular recombination method, for expression in eukaryotic cells. The invention further provides methods of selecting and screening for antigen-specific immunoglobulin molecules, and antigen-specific fragments thereof. ...
Compositions and methods for enhancing homologous recombination
Life Technologies Corporation
October 26, 2017 - N°20170306306

The present disclosure generally relates to compositions and methods for improving the efficiency of homologous recombination. In particular, the disclosure relates to reagents and the use of such reagents.
Materials, fabrication equipment, and methods for stable, sensitive photodetectors and image sensors made therefrom
Life Technologies Corporation
October 19, 2017 - N°20170301808

Optically sensitive devices include a device comprising a first contact and a second contact, each having a work function, and an optically sensitive material between the first contact and the second contact. The optically sensitive material comprises a p-type semiconductor, and the optically sensitive material has a work function. Circuitry applies a bias voltage between the first contact and the ...
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