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Recombinant

Recombinant-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Oligosaccharide production
Glycom A/s
June 22, 2017 - N°20170175154

The invention relates to a genetically modified microorganism for making a recombinant oligosaccharide, preferably of 3-8 monosaccharide units, more preferably of 3-5 monosaccharide units, particularly a hmo, which comprises one or more genes encoding a sucrose utilization system, so the microorganism can use sucrose as a carbon and energy source. The one or more genes encoding a sucrose utilization system ...
NEW Recombinant cyanobacterial cell for contamination control in a cyanobacterial culture producing a chemical compound of ...
Algenol Biotech Llc
June 22, 2017 - N°20170175148

A non-naturally occurring cyanobacterial cell for the production of a chemical compound of interest is provided which contains at least one genetic modification that alters expression of at least one phosphate uptake regulating gene encoding a protein involved in regulation of phosphate metabolism, so that cellular uptake and/or intracellular storage of a phosphate compound is increased in comparison to ...
NEW Pesticidal genes and methods of use
Agbiome, Inc.
June 22, 2017 - N°20170175134

Compositions having pesticidal activity and methods for their use are provided. Compositions include isolated and recombinant polypeptides having pesticidal activity, recombinant and synthetic nucleic acid molecules encoding the polypeptides, dna constructs and vectors comprising the nucleic acid molecules, host cells comprising the vectors, and antibodies to the polypeptides. Polynucleotide sequences encoding the polypeptides can be used in dna constructs or ...
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NEW Methods and compositions for producing vitamin k dependent proteins
The University Of North Carolina At Chapel Hill
June 22, 2017 - N°20170175088

The present invention relates to methods and compositions for improving the productivity of recombinant vitamin k dependent protein expression in host cells.
NEW Paramyxovirus virus-like particles as protein delivery vehicles
The Penn State Research Foundation
June 22, 2017 - N°20170175086

Provided are modified virus-like particles (vlps) of paramyxoviruses, compositions containing them, methods of using the vlps for delivery of any particular protein of interest to any of a variety of cells, kits that contain expression vectors for making, using and detecting vlps, and methods for screening for anti-viral compounds using the vlps. The modified vlps contain a contiguous recombinant polypeptide ...
NEW Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the ...
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
June 22, 2017 - N°20170174771

The invention provides chimeric antigen receptors (cars) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain t cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the cars are disclosed. Methods of detecting the ...
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Recombinant Patent Applications
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NEW Long-acting recombinant human follicle-stimulating hormone-fc fusion protein
Unicomed Pharma Co. Ltd.
June 22, 2017 - N°20170174736

Recombinant fc fusion proteins of human follicle-stimulating hormone (hfsh) with in vivo biological activities comparable to those of human follicle-stimulating hormone are disclosed. A recombinant hfsh-fc fusion protein comprises β subunit of hfsh (hfsh β), ctp, α subunit of hfsh (hfsh α), a flexible peptide linker, and human igg2 fe variant (vigg2fc). A method is ...
NEW Immunogenic compositions for the prevention and treatment of meningococcal disease
Wyeth Holdings Llc
June 22, 2017 - N°20170173140

The present invention relates to neisseria orf2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by ...
NEW Methods of improving production of vanillin
Evolva Sa
June 22, 2017 - N°20170172184

Methods for recombinant production of vanillin and compositions containing vanillin are provided by this invention.
Transgenic bacteria with expanded amino acid usage and nucleic acid molecules for use in the ...
Board Of Regents, The University Of Texas System
June 15, 2017 - N°20170166945

Recombinant bacterial cells are provided that comprise a stable non-canonical amino acid translation pathway. In some aspects, the bacteria comprise nucleic acids encoding a non-canonical amino acid translation pathway (e. G., a trna for incorporation of a non-canonical amino acid, such selenocysteine); a marker polypeptide that includes the non-canonical amino acid. Recombinant trna and selection marker coding sequences are likewise ...
Isolated polynucleotide including promoter region, host cell including the same, and method of expressing target ...
Samsung Electronics Co., Ltd.
June 15, 2017 - N°20170166944

Provided is a recombinant polynucleotide including a promoter region derived from an acetic acid-producing bacterium and a polynucleotide sequence encoding a target protein operably linked to the promoter, a host cell including the same, and a method of expressing a target gene or protein using the host cell.
Overexpression of n-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
Amgen Inc.
June 15, 2017 - N°20170166942

Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the overexpression of proteins involved in the n-glycosylation pathway.
Method for modulating galactosylation of recombinant protein through optimization of culture medium
Lg Life Sciences Ltd.
June 15, 2017 - N°20170166941

Disclosed are a method for preparing a target recombinant protein with modulated galactosylation or a method for modulating the galactosylation of a target recombinant protein, including increasing the osmolality of a culture solution of animal cells which express a target recombinant protein during the animal cell culture; a method for preparing a target recombinant protein with modulated galactosylation or a ...
Recombinant Patent Pack
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Recombinant Patent Applications
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  • 985+ full patent PDF documents of Recombinant-related inventions.
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Microorganism strains for the production of 2.3- butanediol
Alderys
June 15, 2017 - N°20170166935

A recombinant yeast having a reduced pyruvate decarboxylase activity, in the génome of which has been inserted: —one or more nucleic acids encoding an acetolactate synthase or als, —one or more nucleic acids encoding an acetolactate decarboxylase or ald, —one or more nucleic acids encoding a butancdiol dehydrogenase or bdh, and —one or more ...
Isolation of novel aav's and uses thereof
University Of Massachusetts
June 15, 2017 - N°20170166927

The invention in some aspects relates to isolated nucleic acids, compositions, and kits useful for identifying adeno-associated viruses in cells. In some aspects, the invention provides kits and methods for producing somatic transgenic animal models using recombinant aav (raav) to an animal having at least one transgene that expresses a small interfering nucleic acid or at least one binding site ...
Recombinant aav vectors useful for reducing immunity against transgene products
University Of Massachusetts
June 15, 2017 - N°20170166925

The disclosure in some aspects, relates to nucleic acids, compositions and kits useful for gene therapy with reduced immune response to transgene products.
Methods for producing and using in vivo pseudotyped retroviruses
University Of Iowa Research Foundation
June 15, 2017 - N°20170166924

The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to generate high titer recombinant virus stocks expressing novel envelope glycoproteins. The present invention further relates to compositions for gene therapy.
Protein expression from multiple nucleic acids
Hoffmann-la Roche Inc.
June 15, 2017 - N°20170166923

The current invention reports a method for the recombinant production of a secreted heterologous immunoglobulin in a cho cell comprising the following steps: i) providing a cho cell, which is adapted to growth in suspension culture, adapted to growth in serum-free medium, mycoplasma free, and virus free, ii) providing a vector comprising a prokaryotic origin of replication, a first nucleic ...
Recombinant microorganisms having a methanol elongation cycle (mec)
The Regents Of The University Of California
June 15, 2017 - N°20170166902

Provided are microorganisms that catalyze the synthesis of chemicals and biochemicals from a methanol, methane and/or formaldehyde. Also provided are methods of generating such organisms and methods of synthesizing chemicals and biochemicals using such organisms.
Dual controls for therapeutic cell activation or elimination
Bellicum Pharmaceuticals, Inc.
June 15, 2017 - N°20170166877

The technology relates in part to methods for controlling the activity or elimination of therapeutic cells using molecular switches that employ distinct heterodimerizer ligands, in conjunction with other multimeric ligands. The technology may be used, for example to activate or eliminate cells used to promote engraftment, to treat diseases or condition, or to control or modulate the activity of therapeutic ...
Recombinant monovalent antibodies
Institut National De La Sante Et De La Recherche Medicale (inserm)
June 15, 2017 - N°20170166643

The invention relates to recombinant monovalent antibodies which are heterodimers of a first protein chain comprising the variable domain of the heavy chain of an antibody of interest and the ch2 and ch3 domains of an igg immunoglobulin and a second protein chain comprising the variable domain of the light chain of said immunoglobulin of interest and the ch2 and ...
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