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Recombinant

Recombinant-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Novel t cell receptors and immune therapy using the same
Immatics Biotechnologies Gmbh
June 14, 2018 - N°20180164315

The present invention relates to antigen recognizing constructs against a tumor associated antigen (taa) derived from the target protein ddb1 and cul4 associated factor 4-like 2 (dcaf4l2). The invention in particular provides novel t cell receptor (tcr) based molecules which are selective and specific for the taa of the invention.
Expression of recombinant tetracycline efflux pumps for the production of lysine or lysine-derived products, and ...
Cathay Industrial Biotech Ltd.
June 14, 2018 - N°20180163239

The present invention provides a mutant polypeptide comprising the amino acid sequence of escherichia coli tetracycline efflux pump a (teta), and a polynucleotide encoding the polypeptide. The present invention provides a first expression plasmid vector comprising one or more first polynucleotides encoding a tetracycline efflux pump, one or more second polynucleotides independently selected from the group consisting of a third ...
Biosynthesis of phenylpropanoids and phenylpropanoid derivatives
Evolva Sa
June 14, 2018 - N°20180163235

Provided herein are recombinant hosts and methods for producing phenylpropanoid and phenylpropanoid derivative compounds. It was found that tyrosine ammonia lyase from aeromonas salmonicida a449 provides improved coumaric acid production..
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Novel recombinant adeno-associated virus capsids containing a designed ankyrin repeat protein (darpin) or fragment thereof
The Board Of Trustees Of The Leland Stanford Junior University
June 14, 2018 - N°20180163229

The present invention relates to variant aav capsid polypeptides containing designed ankyrin repeat proteins (darpins), wherein the variant capsid polypeptides exhibit an enhanced neutralization profile, increased transduction, and/or tropism in human liver and/or hepatocyte cells, or human pancreas and/or pancreatic cells, as compared to capsid polypeptides that do not include darpins.. .
Method for preparing recombinant adeno-associated virus
Wuhan Institute Of Physics And Mathematics, Chinese Academy Of Sciences
June 14, 2018 - N°20180163228

A method for producing recombinant adeno-associated virus, the method including: (1) transforming a gene of interest (goi) into a recombinant baculovirus, where the recombinant baculovirus has a genome integrated with aav rep gene, cap gene, and raav genome itr-goi that are needed in the production of the raav; and where the itr-goi is linked to expression cassette of the cap gene ...
Recombinant adeno-associated vectors for targeted treatment
City Of Hope
June 14, 2018 - N°20180163227

Novel adeno-associated virus (aav) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues.
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Recombinant Patent Applications
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Recombinant protein, and preparation method and application thereof
June 14, 2018 - N°20180163184

Thermal stability=(value of oxidase activity after heat treatment)/(value of oxidase activity without heat treatment)×100%.. .
Recombinant adeno-associated virus particle purification with multiple-step anion exchange chromatography
Association Francaise Contre Les Myopathies
June 14, 2018 - N°20180163183

The invention describes a method for obtaining purified recombinant adeno-associated virus particles (raav), comprising the steps of: a) performing a depth filtration of a starting material previously obtained from cells producing raav particles, the said starting material being selected in a group comprising a cell lysate and a culture supernatant, whereby a raav-containing clarified composition is provided; b) submitting the ...
Processes for production and purification of nucleic acid-containing compositions
Human Services
June 14, 2018 - N°20180163182

Described are improved processes for production and purification of nucleic acid-containing compositions, such as non-naturally occurring viruses, for example, recombinant polioviruses that can be employed as oncolytic agents. Some of the described improved processes relate to improved processes for producing viral dna template.
Salmonella-based vectors for cancer immunotherapy targeting wilms' tumor gene wt1
Vaximm Ag
June 14, 2018 - N°20180163169

The present invention relates to an attenuated mutant strain of salmonella comprising a recombinant dna molecule encoding wilms' tumor protein i. In particular, the present invention relates to the use of said attenuated mutant strain of salmonella in cancer immunotherapy..
Psma targeting trispecific proteins and methods of use
Harpoon Therapeutics, Inc.
June 14, 2018 - N°20180162949

Provided herein are prostate specific membrane antigen (psma) targeting trispecific proteins comprising a domain binding to cd3, a half-life extension domain, and a domain binding to psma. Also provided are pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such psma targeting trispecific proteins.
Anti-ceacam6 antibodies and uses thereof
Bayer Pharma Aktiengesellschaft
June 14, 2018 - N°20180162940

The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for human and macaca fascicularis ceacam6 (carcinoembryonic antigen-related cell adhesion molecule 6, cd66c, non-specific crossreacting antigen, nca, nca-50/90), and which do not significantly cross-react with the closely related human ceacam1, human ceacam3, and human ceacam5. The invention further provides methods to ...
Recombinant proteins and their therapeutic uses
Bioven 3 Limited
June 14, 2018 - N°20180162917

A recombinant protein expressing one or more human growth factors, tumor antigens, and/or receptors or epitopes thereof on or within an immunogenic expression creating a recombinant protein in which one or more epitopes are presented on the surface of the sequence in their natural configuration. The growth factor, tumor antigen, and/or receptor, sequence(s) may be expressed within ...
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Recombinant Patent Applications
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Growth hormone polypeptides and methods of making and using same
Amunix Operating Inc.
June 14, 2018 - N°20180161443

The present invention relates to compositions comprising growth hormone linked to extended recombinant polypeptide (xten), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of growth hormone-related diseases, disorders, and conditions.. .
Recombinant vaccinia virus having hemagglutinin protein genes derived from novel influenza viruses
National University Corporation Hokkaido University
June 14, 2018 - N°20180161421

Provided are a highly-safe recombinant vaccinia virus that is effective in preventing the onset of symptoms due to infection by novel influenza viruses, and a vaccine for the novel influenza viruses containing the recombinant vaccinia virus. This recombinant vaccinia virus is capable of expressing the hemagglutinin protein genes of the novel influenza virus.
Improved methods for treating ocular diseases by gene therapy
Association FranÇaise Contre Les Myopathies
June 14, 2018 - N°20180161405

The invention relates to a pharmaceutical composition comprising a recombinant adeno-associated virus (r aav) vector carrying a nucleic acid sequence encoding a functional gene under the control of regulatory sequences which express the product of said gene in the retinal cells, for use in a method for preventing or treating an inherited retinal degenerative disorder associated with mutations in said ...
Novel t cell receptors and immune therapy using the same
Immatics Biotechnologies Gmbh
June 14, 2018 - N°20180161396

The present invention pertains to antigen recognizing constructs against tumor associated antigens (magea1). The invention in particular provides novel t cell receptor (tcr) based molecules which are selective and specific for the tumor expressed antigen of the invention.
Therapeutic treatment of skin disease with recombinant commensal skin microorganisms
Azitra
June 14, 2018 - N°20180161380

The invention relates to methods for treating or preventing abnormal skin conditions in a human in need thereof, comprising administering a cell culture composition comprising a living culture of bacteria comprising at least one engineered strain that produces a recombinant polypeptide for therapeutic treatment of the abnormal skin condition. The invention also relates to pharmaceutical compositions containing, as the active ...
Reagents for hcv antigen-antibody combination assays
Ortho-clinical Diagnostics, Inc.
June 07, 2018 - N°20180156799

The present invention is directed to combination immunoassays, reagents and kits for simultaneous detection of hcv antigens and anti-hcv antibodies in a sample. The combination immunoassays of the present invention employ a non-ionic detergent that effectively exposes or releases the hcv core antigen from virions in a sample without interfering with the performance of other reagents such as the capture ...
Manganese supplementation for control of glycosylation in mammalian cell culture process
Biogen Ma Inc.
June 07, 2018 - N°20180155753

The present invention pertains to a cell culture medium comprising manganese as a media supplement, which was shown to control recombinant protein glycosylation and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture..
Recombinant yeast and use thereof
Stellenbosch University
June 07, 2018 - N°20180155744

A recombinant yeast that expresses both an α-amylase (seq id no: 1) and a glucoamylase (seq id no: 2) from talaromyces emersonii (recently re-named as rasamsonia emersonii) is provided. The use of the recombinant yeast in a process for producing an alcohol, in particular a biofuel, from starch or sugars is also described..
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