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Recombinant patents



      
           
This page is updated frequently with new Recombinant-related patent applications. Subscribe to the Recombinant RSS feed to automatically get the update: related Recombinant RSS feeds. RSS updates for this page: Recombinant RSS RSS


Date/App# patent app List of recent Recombinant-related patents
07/24/14
20140208455
 Chimeric promoters capable of mediating gene expression in plants upon pathogen infection and uses thereof patent thumbnailnew patent Chimeric promoters capable of mediating gene expression in plants upon pathogen infection and uses thereof
Described are synthetic promoters capable of mediating gene expression in plants upon pathogen infection. Furthermore, recombinant genes and vectors comprising said chimeric promoters as well as host cells transformed with such chimeric promoters, recombinant genes, or vectors are provided.
07/24/14
20140206901
 Recombinant microorganisms and methods of use thereof patent thumbnailnew patent Recombinant microorganisms and methods of use thereof
The invention relates to methods for the production of chemical compounds, particularly but not exclusively ethanol, by microbial fermentation. Also described are genetically modified micro-organisms capable of using carbon monoxide to produce one or more products, particularly but not exclusively ethanol as a main product, and producing a reduced amount or substantially no 2,3-butanediol and/or a precursor thereof..
07/24/14
20140206851
 Proteins from the webs of nephilengys cruentata, avicularia juruensis and parawixia bistriata spiders isolated from brazilian biodiversity patent thumbnailnew patent Proteins from the webs of nephilengys cruentata, avicularia juruensis and parawixia bistriata spiders isolated from brazilian biodiversity
The present invention relates to molecules isolated from the nucleic acid that encodes spider web proteins or fragments of these or other derivatives of these. The invention also refers to a chimerical gene and an expression vector containing molecules isolated from the nucleic acid that codes for proteins related to the webs of nephilengys, cruentata, avicularia juruensis and parawixia bistriata spiders.
07/24/14
20140206620
 T cell receptors and related materials and methods of use patent thumbnailnew patent T cell receptors and related materials and methods of use
The invention provides t cell receptors (tcrs) having antigenic specificity for a cancer antigen, e.g., tyrosinase. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, and pharmaceutical compositions.
07/24/14
20140206086
 Methods for obtaining positive transformants of a filamentous fungal host cell patent thumbnailnew patent Methods for obtaining positive transformants of a filamentous fungal host cell
The present invention relates to methods for obtaining positive transformants of a filamentous fungal host cell, comprising: transforming a tandem construct into a population of cells of the filamentous fungal host a tandem construct and isolating a transformant of the filamentous fungal host cell comprising the tandem construct. The present invention also relates to such tandem constructs, filamentous fungal host cells comprising such tandem constructs, and methods of producing multiple recombinant proteins..
07/24/14
20140206062
 Recombinant influenza viruses for vaccines and gene therapy patent thumbnailnew patent Recombinant influenza viruses for vaccines and gene therapy
The invention provides compositions and methods useful to prepare segmented, negative strand rna viruses, e.g., orthomyxoviruses such as influenza a viruses, entirely from cloned cdnas and in the absence of helper virus.. .
07/24/14
20140206039
 Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy patent thumbnailnew patent Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy
Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a second expression vector is transformed into a second haploid cell.
07/24/14
20140206038
 Cell culture improvements patent thumbnailnew patent Cell culture improvements
The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture..
07/24/14
20140206037
 Dna vector production system patent thumbnailnew patent Dna vector production system
A vector production system is provided. The system comprises recombinant cells designed to encode at least a first recombinase under the control of an inducible promoter and the cells include an expression vector encoding a nucleic acid of interest within the regulatory elements of the expression vector which are flanked on either side by a target sequence for at least the first recombinase.
07/24/14
20140206021
 Prion protein ligands and methods of use patent thumbnailnew patent Prion protein ligands and methods of use
Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (prpc), infectious prion protein (prpsc), and recombinant prion protein (prpr).
07/24/14
20140205993
new patent Recombinant avian influenza vaccine and uses thereof
The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a subunit vaccine based on the hemagglutinin of influenza.
07/24/14
20140205619
new patent Recombinant avian influenza vaccine and uses thereof
The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a subunit vaccine based on the hemagglutinin of influenza.
07/24/14
20140205583
new patent Use of plp with peg-rmetase in vivo for enhanced efficacy
This invention relates to methods of modifying pyridoxal 5′ phosphate (plp) dependent enzymes to extend the serum half-life of the enzyme, extend the in vivo period of methionine depletion in a host, and decrease the immunogenicity of the enzyme. A preferred plp-dependent enzyme to be modified is a methioninase, preferably a recombinant methioninase (rmetase).
07/24/14
20140205570
new patent Recombinant adeno-associated virus-mediated expression of fractalkine for treatment of neuroinflammatory and neurodegenerative diseases
The subject invention pertains to the use of fractalkine (fkn, cx3cl1) and its receptor cx3cr1 for treatment of neuroinflammation and/or neurodegeneration. In one embodiment, the present invention provides a method for treatment of neuroinflammation and/or neurodegenerative diseases, comprising: administering, to cells of a subject in need of such treatment, an adeno-associated virus that comprises a functional fractalkine gene operably linked to transcriptional control elements.
07/17/14
20140200180
Method for producing proteins in pichia pastoris that lack detectable cross binding activity to antibodies against host cell antigens
Methods for producing proteins and glycoproteins in pichia pastoris that lack detectable cross binding activity to antibodies made against host cell antigens are described. In particular, methods are described wherein recombinant pichia pastoris strains that do not display a β-mannosyltransferase 2 activity with respect to an n-glycan or o-glycan and do not display at least one activity selected from a β-mannosyltransferase 1, 3, and 4 activity to produce recombinant proteins and glycoproteins.
07/17/14
20140200172
Alpha-amylase mutants
The invention relates to a novel termamyl-like alpha-amylase, and termamyl-like alpha-amylases comprising mutations in two, three, four, five or six regions/positions. The variants have increased thermostability at acidic ph and/or at low ca2+ concentrations (relative to the parent).
07/17/14
20140199751
Protein extraction
A method for releasing the content of the periplasmic space of bacterial cells is provided, which comprises incubating the bacterial cells in a solution containing styrene maleic acid copolymer (sma). Also provided is a method of preparing a substantially pure sample of recombinant polypeptide.
07/17/14
20140199732
D-psicose 3-epimerase mutant with improved thermal stability, and continuous production of d-psicose using same
The present invention relates to a d-psicose 3-epimerase variant with improved thermostability by substituting an amino acid at a specific position of an amino acid sequence of a wild type d-psicose 3-epimerase. Further, the present invention provides a recombinant expression vector including a gene of the d-psicose 3-epimerase variant, and a recombinant strain transformed with the recombinant expression vector.
07/17/14
20140199688
Conditionallly replication-competent adenovirus
The present invention provides a polynucleotide, which comprises human telomerase reverse transcriptase (htert) promoter, e1a gene, ires sequence and e1b gene in this order and which comprises a target sequence of a first mirna. The present invention also provides a recombinant adenovirus, which comprises a replication cassette comprising the above polynucleotide, wherein the replication cassette is integrated into the e1 region of the adenovirus genome..
07/17/14
20140199343
Recombinant vaccine against prrs in a viral vector
A live or inactivated recombinant vaccine is described, comprising a viral vector and a pharmaceutically acceptable vehicle, adjuvant and/or excipient, wherein the viral vector is capable of generating a cell immune response due to an increased alpha and/or gamma interferon production, and is capable of a quick replication, and it has inserted a nucleotide sequence of the orf 5 and orf 6 from prss.. .
07/17/14
20140199303
Stable liquid formulation of etanercept
The present invention relates to a stable liquid formulation of etanercept (recombinant p75 stnfr:fc fusion protein), and more particularly, to a liquid formulation comprising one or more stabilizers selected from the group consisting of methionine, lysine, histidine, and pharmaceutically acceptable salts thereof in an amount sufficient to reduce by-product formation of etanercept during storage. The liquid formulation according to the present invention effectively reduces production of etanercept by-products and to stably maintain its pharmaceutical efficacies for long-term storage.
07/17/14
20140199301
Recombinant antibody structures binding to and blocking the activity of vascular endothelial growth factor 2 (vegfr- 2/kdr)
Phage displayed recombinant antibody library was developed and the library was screened against vegfr-2. After screening and elisa experiments two recombinant antibodies showing binding properties to vegfr-2 was obtained.
07/10/14
20140196173
Plants having altered agronomic characteristics under nitrogen limiting conditions and related constructs and methods involving genes encoding lnt6 polypeptides and homologs thereof
Isolated polynucleotides and polypeptides and recombinant dna constructs particularly useful for altering agronomic characteristics of plants under nitrogen limiting conditions, compositions (such as plants or seeds) comprising these recombinant dna constructs, and methods utilizing these recombinant dna constructs. The recombinant dna construct comprises a polynucleotide operably linked to a promoter functional in a plant, wherein said polynucleotide encodes an lnt6 polypeptide or homolog thereof..
07/10/14
20140196161
Transgenic plants with enhanced agronomic traits
This invention provides recombinant dna for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. Also provided by this invention is transgenic seed for growing a transgenic plant having recombinant dna in its genome and exhibiting an enhance agronomic trait, i.e.
07/10/14
20140194370
Silk-elastin like protein polymers for embolization and chemoembolization to treat cancer
A chemoembolic agent is disclosed that includes an injectable, recombinantly synthesized silk-elastin like protein copolymer and one or more chemotherapeutic agents. Upon injection, the chemoembolic agent blocks the tumor vasculature, including the capillary bed, and may optionally release chemotherapeutic agents.
07/10/14
20140194322
Methods for creating and identifying functional rna interference elements
The invention relates to the control of gene expression. Specifically, the invention provides compositions and methods for the production and use of recombinant nucleic acid molecules that have the ability to specifically downregulate an expressed target gene in vivo.
07/10/14
20140193856
Control of gene expression
The present invention relates generally to a method of modifying gene expression and to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention utilizes recombinant dna technology to post-transcriptionally modify or modulate the expression of a target gene in a cell, tissue organ or whole organism, thereby producing novel phenotypes.
07/10/14
20140193854
Method for mass-producing antifreeze protein derived from polar yeast
The present invention relates to a method for mass-producing an antifreeze protein derived from a polar yeast, and more particularly, to a method for mass-producing an antifreeze protein derived from leucosporidium sp., which is the polar yeast, for synthesizing a recombinant polynucleotide by optimizing and altering a gene, which codes the antifreeze protein derived from the polar yeast, for a yeast expression system, and for expressing same using the yeast expression system.. .
07/10/14
20140193448
Vaccine against multitypes of avian influenza viruses and uses thereof
The present invention relates to a recombinant dna molecule encoding a mutated hemagglutinin protein, wherein the mutated hemagglutinin protein consists of the amino acid sequence of seq id no: 2 with one or more mutations at amino acid residue selecting from the group consisting of residue 83, 127, 138 and the combination thereof. The present invention also relates to a composition comprising the recombinant dna molecule as described above and a pharmaceutically or veterinarily acceptable carrier, excipient, adjuvant, or vehicle.
07/10/14
20140193441
Method of administering porcine b-domainless fviii
The present invention provides a method of administering porcine b-domainless factor viii (obi-1) to a patient having factor viii deficiency to provide more rapid and effective protection against bleeding episodes, compared to formerly available methods, or to provide more effective protection to such patients during non-bleeding periods. This invention is based on the discovery that the recombinant b-domainless porcine fviii, termed obi-1, has greater bioavailability compared to the natural porcine fviii partially purified from porcine plasma, termed hyate:c.
07/10/14
20140193439
Vaccines and immunotherapeutics comprising il-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same
Compositions, recombinant vaccines and live alternated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes il-15ra or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed..
07/10/14
20140193400
Stable and soluble antibodies inhibiting tnf alpha
The present invention relates to particularly stable and soluble scfv antibodies and fab fragments specific for tnf, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of tnf, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of tnf-mediated disorders.
07/10/14
20140193357
Derivatives of recombinant proteins, homo-multimers of granulocyte colony-stimulating factor and method of preparation thereof
The invention relates to derivatives of recombinant proteins, comprising homo-multimers of genetically fused recombinant biologically active protein monomer units, connected via selected peptide linker moiety; and the method of preparation thereof. Derivative of recombinant protein is preferably dimer of human granulocyte colony-stimulating factor, characterised by increased circulation time in vivo..


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This listing is a sample listing of patent applications related to Recombinant for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Recombinant with additional patents listed. Browse our RSS directory or Search for other possible listings.
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