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Recombinant

Recombinant-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Detection method using recombinant living cells for detecting xenobiotic substances and arrangement and test kit ...
Alfred-wegener-institut Helmholtz-zentrum Fuer Polar-und Meeresforschung
August 17, 2017 - N°20170234856

Dynamic expression behavior of recombinant living cells is used and detects translocation in an integral manner, preferably using a cell-inherent defense system, preferably gene sequences, ai-mi, in recombinant cells in a test kit for performing the detection method code for transporter proteins, ai, with fluorescent marker proteins, mi, as fusion constructs, ai-mi. The cell-inherent defense system is activated under the ...
Biofabricated material containing collagen fibrils
Modern Meadow, Inc.
August 17, 2017 - N°20170233944

A biofabricated material comprising a network of crosslinked collagen fibrils produced from recombinant collagen that contains substantially no 3-hydroxyproline residues is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural ...
Method for making a biofabricated material containing collagen fibrils
Modern Meadow, Inc
August 17, 2017 - N°20170233834

Described herein is a method for producing a biofabricated material from collagen or collagen-like proteins which are recombinantly produced and which contain substantially no 3-hydroxyproline. The collagen or collagen-like proteins are isolated from animal sources, or produced by recombinant dna techniques or by chemical synthesis. The collagen or collagen-like proteins are fibrillated, crosslinked, dehydrated and lubricated thus forming the biofabricated ...
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Compositions and methods for transcription-based crispr-cas dna editing
The Rockefeller University
August 17, 2017 - N°20170233729

Provided are compositions and methods for cleaving a dna sequence in a cell. The methods involve comprising introducing into a cell a recombinant vector containing a clustered regularly interspaced short palindromic repeats (crispr) system. The system includes a crispr rna (crrna) targeted to a dna sequence in the cell that is operatively linked to a promoter; and crispr-associated enzymes (cas) 10, ...
Production for recombinant human dnase i
Jcr Pharmaceuticals Co., Ltd.
August 17, 2017 - N°20170233704

Disclosed is a method for production of recombinant human dnase i which is of such high purity as may be directly used as a medical drug. The method includes the steps of; culturing recombinant dnase i-producing mammalian cells, subjecting a culture supernatant to an anion-exchange column chromatography, subjecting to a column chromatography employing as solid phase a material having affinity ...
Cultured mammalian limbal stem cells, methods for generating the same, and uses thereof
The Regents Of The University Of California
August 17, 2017 - N°20170233698

The invention provides an isolated limbal stem or progenitor cell (lsc) population or lsc-like population comprising a chemically synthesized, recombinant or isolated nucleic acid encoding pax6 integrated into a chromosome, or alternatively, not integrated remaining as an extrachromosomal genetic material, wherein the isolated lsc population is substantially free of non-lsc cells or wherein the lsc-like population is substantially free of ...
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Human antibody specific to c-met and preparation method thereof
Pharmabcine Inc.
August 17, 2017 - N°20170233492

Provided are an antibody specifically bound to c-met (c-met-specific antibody) or fragments thereof, and more specifically, a fully human antibody having high affinity and specificity to c-met isolated from human fv(scfv) phage library, a polynucleotide encoding the antibody, a recombinant vector containing the polynucleotide, a cell transformed with the recombinant vector, and a method of producing the c-met-specific antibody ...
Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
Baxalta Gmbh
August 17, 2017 - N°20170233455

The present disclosure provides, among other aspects, codon-altered polynucleotides encoding factor viii variants for expression in mammalian cells. In some embodiments, the disclosure also provides mammalian gene therapy vectors and methods for treating hemophilia a.
Recombinant hiv-1 envelope proteins and their use
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
August 17, 2017 - N°20170233441

Hiv-1 env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the hiv-1 env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to hiv-1 in a subject. In additional embodiments, the therapeutically effective amount of the hiv-1 env ectodomain trimers can ...
Aav virions with decreased immunoreactivity and uses therefor
Genzyme Corporation
August 17, 2017 - N°20170232117

Methods of making and using recombinant aav virions with decreased immunoreactivity are described. The recombinant aav virions include mutated capsid proteins or are derived from non-primate mammalian aav serotypes and isolates that display decreased immunoreactivity relative to aav-2.
Recombinant mumps virus vaccine
University Of Georgia Research Foundation, Inc.
August 17, 2017 - N°20170232098

The present invention provides the complete genomic sequence of the epidemic mumps virus (muv) strain muviowa/us/06. Further, a reverse genetics system was constructed and used to rescue recombinant viral constructs that are attenuated compared to rmuviowa/us/06 and jl vaccine viruses. Such constructs include viral constructs lacking the open reading frame (orf) of the sh gene (rmuvΔsh) ...
Vaccine in the form of a recombinant sero type 9 avian adenovirus vector
University Of Georgia Research Foundation, Inc.
August 17, 2017 - N°20170232096

The vector of this vaccine is stable for industrial scale production. Likewise, even when administering this vaccine in combination with a vaccine against marek's disease, both vaccines produce an adequate immune response which is not affected by interference between each other. In the same way, effectiveness of the recombinant vaccine is not affected by maternal antibodies, and is capable of ...
Functional influenza virus-like particles (vlps)
Novavax, Inc.
August 17, 2017 - N°20170232095

Recombinant influenza virus proteins, including influenza capsomers, subviral particles, virus-like particles (vlp), vlp complexes, and/or any portions of thereof, are provided as a vaccine for influenza viruses. The invention is based on the combination of two vaccine technologies: (1) intrinsically safe recombinant vaccine technology, and (2) highly immunogenic, self-assembled protein macromolecules embedded in plasma membranes and comprised of multiple copies of ...
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Recombinant Patent Applications
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  • 985+ full patent PDF documents of Recombinant-related inventions.
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Method for prophylaxis and/or treatment of erbb1 positive cancers
Health Research, Inc.
August 17, 2017 - N°20170232078

Provided are compositions and methods for prophylaxis and/or therapy of erbb1-positive cancer. The compositions include pharmaceutical preparations that contain isolated or recombinant or modified peptidase d (pepd) proteins. The methods include prophylaxis and/or therapy of erbb1-positive cancer by administering a pepd to an individual who has or is at risk for developing erbb1-positive cancer.
Bacteria engineered to treat disorders involving the catabolism of a branched chain amino acid
Synlogic, Inc.
August 17, 2017 - N°20170232043

The present disclosure provides recombinant bacterial cells that have been engineered with genetic circuitry which allow the recombinant bacterial cells to sense a patient's internal environment and respond by turning an engineered metabolic pathway on or off. When turned on, the recombinant bacterial cells complete all of the steps in a metabolic pathway to achieve a therapeutic effect in a ...
7-beta-hydroxysteroid dehydrogenase mutants and process for the preparation of ursodeoxycholic acid
Pharmazell Gmbh
August 10, 2017 - N°20170226556

The invention relates to novel 7β-hydroxysteroid dehydrogenase mutants, to the sequences which code for these enzyme mutants, to processes for the preparation of the enzyme mutants and to their use in enzymatic conversions of cholic acid compounds, in particular in the preparation of ursodeoxycholic acid (udca); subject-matter of the invention is also novel processes for the synthesis of ...
Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using cobalt
Abbvie Inc.
August 10, 2017 - N°20170226552

The present invention relates to the field of protein production and, in particular, to methods and compositions for modulating the glycosylation of recombinant proteins expressed in host cells using cell culture media supplemented with cobalt.
Inhibitory rna for enhanced protein production in recombinant mammalian cells
Merck Sharp & Dohme Corp.
August 10, 2017 - N°20170226550

The invention provides methods and compositions for improving production of exogenous polypeptides in large scale culture of mammalian host cells. The methods and compositions utilize rna interference to inhibit expression of one or more specific host cell proteins. The present invention is based on the identification of specific mammalian genes and sequences therein that are useful as rnai targets to ...
Biological processes for the production of aryl sulfates
Danmarks Tekniske Universitet
August 10, 2017 - N°20170226543

The present invention generally relates to the field of biotechnology as it applies to the production of aryl sulfates using polypeptides or recombinant cells comprising said polypeptides. More particularly, the present invention pertains to polypeptides having aryl sulfotransferase activity, recombinant host cells expressing same and processes for the production of aryl sulfates employing these polypeptides or recombinant host cells.
Genetically recombinant saccharomyces cerevisiae for degrading kitchen waste
Guangdong Qizhi Biotechnology Co., Ltd
August 10, 2017 - N°20170226539

Disclosed is a genetically recombinant saccharomyces cerevisiae useful for degrading and utilizing kitchen wastes. Genes encoding α-amylase(amy), glucoamylase (ga) and acid protease (ap) were introduced into the genetically recombinant saccharomyces cerevisiae using a saccharomyces cerevisiae multi-gene co-expression vector and successfully expressed and secreted. The saccharomyces cerevisiae so obtained are capable of secreting amylases and protease to degrade ...
Dhad variants and methods of screening
Butamax Advanced Biofuels Llc
August 10, 2017 - N°20170226497

Methods of screening for dihydroxy-acid dehydratase (dhad) variants that display increased dhad activity are disclosed, along with dhad variants identified by these methods. Such enzymes can result in increased production of compounds from dhad requiring biosynthetic pathways. Also disclosed are isolated nucleic acids encoding the dhad variants, recombinant host cells comprising the isolated nucleic acid molecules, and methods of producing ...
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