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Recombinant

Recombinant-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Genes and uses for plant improvement
Monsanto Technology Llc
October 12, 2017 - N°20170292131

Transgenic seed for crops with improved traits are provided by trait-improving recombinant dna where plants grown from such transgenic seed exhibit one or more improved traits as compared to a control plant. Exemplary recombinant dna expresses a succinate semialdehyde dehydrogenase.
Microbial production of alkanolamides and amidoamines and uses thereof
Reg Life Sciences, Llc
October 12, 2017 - N°20170292120

The disclosure relates to a recombinant microorganism engineered to express an enzyme which catalyzes the conversion of a primary amine and an acyl thioester to a fatty amide. The disclosure further encompasses a method of producing a fatty amide by culturing the recombinant microorganism in the presence of a carbon source.
Proteins increasing pancreatic beta cell number and methods of use
University Of Oregon
October 12, 2017 - N°20170292115

Disclosed herein are bacterial proteins that increase pancreatic beta (β) cell number and/or proliferation, methods of increasing β cell number and/or proliferation using such proteins, and methods of treating or inhibiting diabetes in a subject by administering such proteins to the subject. In some embodiments, the protein has at least 80% sequence identity to the amino acid ...
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Compositions and methods for the modulation of ras proteins
New York University
October 12, 2017 - N°20170291958

Described herein is a method of modulating sumoylation of a ras protein by small ubiquitin-like modifier (sumo) proteins. Provided herein is a method for regulating the activity of a ras protein. Also provided is a treatment of proliferative diseases, such as cancer, by introducing specific mutations to a mutant ras protein that is associated with the proliferative disease. Described herein ...
Jam-c antibodies and methods for treatment of cancer
Research Development Foundation
October 12, 2017 - N°20170291944

A novel method to reduce b-cell lymphoma cell migration to and engraftment of the spleen in patients with jam-c positive b-cell lymphomas is described. In certain aspects, a method for identifying and treating jam-c positive b-cell lymphoma patients with anti-jam-c antibodies is provided. Recombinant antibody molecules that specifically bind to jam-c are also disclosed.
Production cell line enhancers
Regeneron Pharmaceuticals, Inc.
October 12, 2017 - N°20170291938

The present invention relates to discovery of the ectopic expression of edem2 in a production cell to improve the yield of a useful multi-subunit protein. Thus, the present invention provides for production cell lines, such as the canonical mammalian biopharmaceutical production cell, the cho cell, containing recombinant polynucleotides encoding edem2. Also disclosed is a production cell containing both an edem2...
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Recombinant Patent Applications
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Methods and compositions for intra-nasal immunization with recombinant mva encoding flagellin
Bavarian Nordic A/s
October 12, 2017 - N°20170290909

Provided herein are immunogenic compositions comprising a recombinant modified vaccinia virus ankara (mva) comprising a nucleic acid sequence encoding a flagellin, and a nucleic acid sequence encoding a heterologous disease-associated antigen, wherein the immunogenic composition induces increased t-cell and antibody mediated immune responses specific for the heterologous disease-associated antigen when administered to a subject, e. G. A human subject, and ...
Compositions comprising recombinant bacillus cells and an insecticide
Spogen Biotech Inc.
October 12, 2017 - N°20170290339

The present invention relates to a composition comprising a) recombinant exosporium-producing bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the bacillus cells; and b) at least one particular insecticide disclosed herein in a synergistically effective amount. ...
Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
Washington State University Research Foundation
October 05, 2017 - N°20170283839

The amino acid and nucleic acid sequences of a Δ5-desaturase enzyme and a Δ8-desaturase enzyme are disclosed. The nucleic acid sequences can be used to design recombinant dna constructs and vectors. These vectors can then be used to transform various organisms, including for example, plants and yeast. The transformed organisms will then produce polyunsaturated fatty acids. The amino ...
Variants of gal2 transporter and their uses
Butalco Gmbh
October 05, 2017 - N°20170283835

The present invention relates to polypeptides which are gal2 variants comprising at least one amino acid substitution at a position corresponding to t354, and optionally further amino acid substitution(s). The present invention further relates to nucleic acid molecules encoding the polypeptides and to host cells containing said nucleic acid molecules. The present invention further relates to a method for ...
Methods for genetic control of insect infestations in plants and compositions thereof
Monsanto Technology Llc
October 05, 2017 - N°20170283828

The present invention relates to control of pest infestation by inhibiting one or more biological functions. The invention provides methods and compositions for such control. By feeding one or more recombinant double stranded rna molecules provided by the invention to the pest, a reduction in pest infestation is obtained through suppression of gene expression. The invention is also directed to ...
Recombinant microorganism producing alkenes from acetyl-coa
Global Bioenergies
October 05, 2017 - N°20170283809

Disclosed is a recombinant microorganism comprising endogenous enzymes that convert co and/or co2 to acetyl-coa. The recombinant microorganism contains a heterologous nucleic acid sequence encoding one or more enzymes that allow the conversion of acetyl-coa to an alkene with a main chain of 1 to 5 carbon atoms. The heterologous nucleic acid sequence comprises one or more coding sequences encoding one ...
Bacteriophage engineering methods
The Charles Stark Draper Laboratory, Inc.
October 05, 2017 - N°20170283779

The present disclosure provides methods and kits for generating recombinant bacteriophage genomes.
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Partial adaption for butanol production
Butamax Advanced Biofuels Llc
October 05, 2017 - N°20170283765

Provided herein are processes for producing an improved culture of cells comprising an engineered butanol biosynthetic pathway. The processes comprise (a) providing a cell culture of recombinant microorganisms comprising an engineered butanol biosynthetic pathway, wherein the engineered butanol biosynthetic pathway is minimal or not activated; and (b) growing the culture of recombinant microorganisms under adaptive conditions whereby pathway activation is ...
Modified j-chain
Igm Biosciences, Inc.
October 05, 2017 - N°20170283510

The present invention concerns modified recombinant j-chain polypeptides, binding molecules, such as antibodies comprising the same, and their uses.
Production of proteins in glutamine-free cell culture media
Genentech, Inc.
October 05, 2017 - N°20170283505

The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
Ror1 (ntrkr1) specific chimeric antigen receptors for cancer immunotherapy
Cellectis
October 05, 2017 - N°20170283497

The present invention relates to chimeric antigen receptors (car) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scfv derived from a ror1 monoclonal antibody, conferring specific immunity against ror1 positive cells. The engineered immune cells endowed with such cars are particularly ...
Compositions comprising recombinant bacillus cells and another biological control agent
Spogen Biotech Inc.
October 05, 2017 - N°20170283472

The present invention relates to a composition comprising a) recombinant exosporium-producing bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the bacillus cells; and b) at least one further biological control agent selected from particular microorganisms disclosed ...
Universal platform for targeting therapies to treat neurological diseases
Wisconsin Alumni Research Foundation
October 05, 2017 - N°20170281737

The present invention provides a universal delivery platform of functional, heterologous compounds to specific cells using toxins modified to include a heterologous compound. In one embodiment, the toxin is an ab5 toxin. In one embodiment, the ab5 toxin is a heat-labile enterotoxin from e. Coli (lt), including lti, ltii, ltiia, ltiib, ltiic and other recombinant forms of lt. Methods of ...
Factor viii polypeptide formulations
Bioverativ Therapeutics Inc.
October 05, 2017 - N°20170281734

The present invention provides a formulation of a factor viii polypeptide, e. G., fviii-fc, and methods of using the same. The fviii polypeptide can be a recombinant fviii protein, a short-acting fviii protein, or a long-acting fviii protein. The pharmaceutical formulation comprising a fviii polypeptide can be used for individual prophylaxis, weekly prophylaxis, episodic (on-demand) treatment, or perioperative management of ...
Methods and kits for measuring von willebrand factor
The Medical College Of Wisconsin, Inc.
September 28, 2017 - N°20170276691

Methods and kits for measuring levels of von willebrand factor function in a sample without using a platelet aggregation agonist, such as ristocetin, comprising recombinant glycoprotein ibα having a combination of g233v, d235y and m239v mutations and an agent to detect a complex between the recombinant glycoprotein ibα and von willebrand factor.
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