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Recombinant

Recombinant-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Genetically encoded biosensors
The Brigham & Women's Hospital, Inc.
January 18, 2018 - N°20180017553

The present disclosure provides, inter alia, genetically encoded recombinant peptide biosensors comprising analyte-binding framework portions and signaling portions, wherein the signaling portions are present within the framework portions at sites or amino acid positions that undergo a conformational change upon interaction of the framework portion with an analyte.
NEW Recombinant phe-free proteins for use in the treatment of phenylketonuria
Nexttobe Ab
January 18, 2018 - N°20180016613

The present invention relates to a method for preparing a recombinant phe-free or phe-low protein, the method comprising using b. Subtilis or b. Licheniformis as an expression system and/or a recombinant host cell into which a nucleotide encoding a recombinant phe-free or phe-low protein has been inserted into the genome.
NEW Method for rapid in vitro synthesis of bioconjugate vaccines via recombinant production of n-glycosylated proteins ...
Cornell University
January 18, 2018 - N°20180016612

Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated proteins. The glycosylated proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated proteins may ...
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NEW Process for producing itaconic acid under anaerobic conditions
Dsm Ip Assets B.v.
January 18, 2018 - N°20180016604

The present invention relates to a method for the production of itaconic acid, which method comprises fermenting a recombinant cell capable of producing itaconic acid in a suitable fermentation medium, thereby to produce itaconic acid, wherein: (a) the recombinant cell: (i) overexpresses cis-aconitate decarboxylase; and (ii) overexpresses a part of the citric acid cycle and/or has reduced activity of ...
NEW Recombinant cytomegalovirus vectors as vaccines for tuberculosis
Oregon Health And Science University
January 18, 2018 - N°20180016599

The present disclosure provides cytomegalovirus vectors encoding fusion proteins comprising mycobacterium tuberculosis (mtb) antigens, nucleic acid molecules encoding the same, cytomegalovirus vectors comprising nucleic acid molecules, compositions comprising the same, and methods of eliciting an immune response against tuberculosis.
NEW Simian adenoviruses sadv-43, -45, -46, -47, -48, -49, and -50, and uses thereof
The Trustees Of The University Of Pennsylvania
January 18, 2018 - N°20180016598

A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus 43, 45, 46, 47, 48, 49 or 50 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
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NEW L-arabinose assimilation pathway and uses thereof
Deinove
January 18, 2018 - N°20180016586

The present invention relates to a new l-arabinose assimilation pathway and uses thereof. In particular, the present invention relates to polypeptides exhibiting l-arabinose isomerase, l-ribulokinase or l-ribulose-5-phosphate-4-epimerase activity, and recombinant host cells expressing said polypeptides. The present invention also relates to a method of producing a fermentation product, preferably ethanol, from an arabinose containing substrate, using a polypeptide ...
NEW Alpha-galactosidase a from material containing contaminant host cell proteins
Jcr Pharmaceuticals Co., Ltd.
January 18, 2018 - N°20180016564

Disclosed is a method for production of recombinant human alpha-galactosidase a (rh alpha-gal a) in a large scale, with a high purity. The method comprises the steps of (a) culturing rh alpha-gal a-producing mammalian cells in a serum-free medium, (b) collecting culture supernatant, (c) subjecting the culture supernatant to anion-exchange column chromatography, (d) to hydrophobic column chromatography, (e) to a ...
NEW Recombinant mdv1 and the uses thereof
Ceva Sante Animale
January 18, 2018 - N°20180016559

The present invention relates to recombinant mdv1 viruses and the uses thereof. The invention is particularly suited to vaccinate poultry against avian pathogens.
NEW Stock solution of retrovirus like particles with method and kit
Mockv Solutions, Inc.
January 18, 2018 - N°20180016558

The present invention relates to a stock solution (rlp stock solution) of mammalian cell-endogenous retrovirus like particles (rlp, a method of preparing a rlp stock solution, a kit containing a rlp stock solution, and a method of quantifying the amount of rlp removed from a solution. An rlp stock solution will contain a high concentration of rlp and an extremely ...
NEW Method for obtaining high-yield, stable expression cell clones and antibody molecules obtained thereby
Centro De Inmunologia Molecular
January 18, 2018 - N°20180016353

Provided is a method for obtaining high-yield, stable expression cell clones from myeloma cell lines in a protein-free culture medium. The method is used for industrial production of a recombinant antibody, and includes three stage: (1) adapting to a protein-free culture medium, statically culturing cells at a low density, and gradually reducing a fat-rich supplement to a chemical culture medium; (2) adapting ...
NEW Bispecific antibody binding to trailr2 and psma
Kyowa Hakko Kirin Co., Ltd
January 18, 2018 - N°20180016346

The present invention is related to a bispecific antibody or an antibody fragment thereof comprising an antigen binding domain that binds to a trailr2, and an antigen binding domain that binds to a psma; a nucleic acid comprising a nucleotide sequence that encodes the antibody or the antibody fragment thereof; a recombinant vector comprising the nucleic acid; a transformant comprising ...
NEW Fusion proteins of superfolder green fluorescent protein and use thereof
Suzhou Kunpeng Biotech Co., Ltd.
January 18, 2018 - N°20180016310

The present disclosure pertains to methods of producing recombinant peptides that contain between 10 and 200 amino acid residues using novel carrier proteins derived from superfolder green fluorescent protein and its mutants.
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NEW Method and composition to increase radiation-induced tumor therapeutic effects
Vascular Biogenics Ltd.
January 18, 2018 - N°20180015183

Disclosed herein are methods and compositions for treating cancer by increasing radiation-induced damage to cancer without increasing radiation-induced side effects by increasing secretory asmase levels specifically in tumor endothelium, and inducing apoptosis of tumor endothelial cells by treating the tumor with radiation. Asmase levels are increased in tumor endothelium by administration of a recombinant dna construct comprising a region coding ...
NEW In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus-like ...
Kuros Biosciences Ag
January 18, 2018 - N°20180015160

The invention relates to the finding that stimulation of antigen presenting cell (apc) activation using substances such as anti-cd40 antibodies or dna oligomers rich in non-methylated c and g (cpgs) can dramatically enhance the specific t cell response obtained after vaccination with recombinant virus like particles (vlps) coupled, fused or otherwise attached to antigens. While vaccination with recombinant vlps fused ...
NEW Cmv antigens and uses thereof
Glaxosmithkline Biologicals, S.a.
January 18, 2018 - N°20180015159

The invention relates to a recombinant human cytomegalovirus (cmv) protein dimeric complex comprising cmv gh protein or a complex-forming fragment thereof, and cmv ul116 or a complex-forming fragment thereof. Also provided herein are nucleic acids encoding said gh/ul116 dimeric complex, host cells for recombinant expression of said gh/ul116 dimeric complex, and the use of said gh/ul116 dimeric ...
NEW Combination of protein forms for hornfly vaccination
Auburn University
January 18, 2018 - N°20180015155

Thrombostasin is an anti-clotting protein found in saliva of haematobia irritans. Disclosed herein are studies testing blood uptake of horn flies feeding on cattle which confirm the association of ts genotype with blood uptake of horn flies. Blood uptake volumes of homozygous ts10 horn flies were lower than those of other ts genotypes when fed on control cattle. Cattle vaccinated ...
Engineered strain of escherichia coli for production of poly-r-3-hydroxyalkanoate polymers with defined monomer unit ...
The Research Foundation For The State University Of New York
January 11, 2018 - N°20180010156

Methods and systems for producing prescribed unit size poly(3-hydroxyalkanoate) (pha) polymers and copolymers are provided. The methods and systems can employ recombinant bacteria that are not native producers of pha or lack enzymes to degrade pha once synthesized, metabolize short to long chain fatty acids without induction, and express an (r)-specific enoyl-coa hydratase and a pha synthase, the (...
Systemic delivery and regulated expression of paracrine genes for cardiovascular diseases and other conditions
The Regents Of The University Of California
January 11, 2018 - N°20180010148

In alternative embodiments, the invention provides methods for treating, ameliorating or protecting (preventing) an individual or a patient against a disease, an infection or a condition responsive to an increased paracrine polypeptide level in vivo comprising: providing a paracrine polypeptide-encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence; or an expression vehicle, a vector, a recombinant virus, ...
Enzymes and methods for producing omega-3 fatty acids
Grains Research And Development Corporation
January 11, 2018 - N°20180010141

The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that ...
Production of fatty acid derivatives
Reg Life Sciences, Llc
January 11, 2018 - N°20180010137

The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than ...
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