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Receptor

Receptor-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Multi-pupil display system for head-mounted display device
June 22, 2017 - N°20170176747

Disclosed are an apparatus and method for increasing the fov of displayed images in a head-mounted display (hmd) device. A display apparatus comprises a display module and a waveguide optically coupled to the display module. The display module may generate individually multiple different portions of an image, to be conveyed to an optical receptor of a user of the hmd ...
Ultrasensitive androgen receptor bioassay
Regents Of The Ultrasensitive Of California
June 22, 2017 - N°20170176467

Provided herein are novel assays for the measurement of androgens such as testosterone in a sample. The assays utilize sensitive androgen receptor mutants and have much greater sensitivity than assays based on wild-type androgen receptors. The assays of the invention can detect androgens at concentrations as low as 1 ng/dl in serum, urine, environmental samples and other samples. The invention ...
Diagnosis of cancer by detecting auto-antibodies against vascular endothelial growth factor receptor (vegfr)
Celltrend Gmbh
June 22, 2017 - N°20170176444

The present invention relates to a method for diagnosis of a cancer, comprising the steps of (i) determining the level of antibodies against vascular endothelial growth factor receptor (vegfr) in a sample from a subject to be diagnosed, (ii) comparing the determined level in the sample to a control level derived from subjects without cancer; wherein a decreased level in ...
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Refrigerator
Lg Electronics Inc.
June 22, 2017 - N°20170176086

A home appliance includes a main body having a storage compartment, a first door hingedly coupled to the main body that opens and closes the storage compartment, and a second door that rotates relative to the first door. The second door includes a latch receptor. The first door includes a locking device with a magnetic component and a latch member. ...
Storage case with locking mechanism
Lg Electronics Inc.
June 22, 2017 - N°20170175422

The present invention provides a locking mechanism for particular use in securing doors of a storage safe. The locking mechanism, generally, includes an elongated band, at least one plate rotatably connected to the elongated band, and at least one rod rotatably connected to the at least one plate. The locking mechanism further includes means for actuating for actuating the locking ...
Pore-forming protein conjugate compositions and methods
The Trustees Of Columbia University In The City Of New York
June 22, 2017 - N°20170175183

The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore-forming protein, such as α-hemolysin, to a biomolecule, such as antibodies, receptors, and enzymes, such as dna polymerase, and the use of such pore-forming protein conjugates in nanopore devices and methods.
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Self assembling nucleic acid nanostructures
Exicure, Inc.
June 22, 2017 - N°20170175121

Stable self-assembling nucleic acid nanostructures comprising: —a plurality of oligonucleotides, —a plurality of g-quadruplex forming nucleic acids linked to the plurality of oligonucleotides, and —a plurality of g-quadruplex stabilizing domains linked to the g-quadruplex forming nucleic acids. The nucleic acid nanostructures are suitable for use as agonists or antagonists of nucleic acid interacting complexes, such as toll-like ...
Paramyxovirus virus-like particles as protein delivery vehicles
The Penn State Research Foundation
June 22, 2017 - N°20170175086

Provided are modified virus-like particles (vlps) of paramyxoviruses, compositions containing them, methods of using the vlps for delivery of any particular protein of interest to any of a variety of cells, kits that contain expression vectors for making, using and detecting vlps, and methods for screening for anti-viral compounds using the vlps. The modified vlps contain a contiguous recombinant polypeptide ...
Combination of anti-pd-1 antibodies and anti-cd20/anti-cd3 antibodies to treat cancer
Regeneron Pharmaceuticals, Inc.
June 22, 2017 - N°20170174779

The present invention provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e. G., a b-cell cancer such as hodgkin's lymphoma or acute lymphoblastic leukemia). The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of an antibody or antigen-binding fragment thereof that specifically binds to programmed death 1 (...
Ph dependent antibodies targeting the transferrin receptor
Wisconsin Alumni Research Foundation
June 22, 2017 - N°20170174778

A ph-dependent antibody that binds an antigen with high affinity at a first ph and rapidly dissociates at a second ph, wherein the antigen is a transferrin receptor (tfr), wherein the association at the second ph/the first ph is less than 20%, and wherein the ph-dependent antibody comprises at least two consecutive histidine residues at a single complementarity determining region (...
Method and constructs for the ph dependent passage of the blood-brain-barrier
Roche Glycart Ag
June 22, 2017 - N°20170174776

Herein is reported a fusion polypeptide comprising i) at least one binding site, e. G. Which comprises an antibody heavy chain variable domain and an antibody light chain variable domain, and which binds to an internalizing cell surface receptor, and ii) at least one pharmaceutically active compound, whereby the ec50-value of the binding pair that binds to an internalizing ...
Combination of a pd-1 antagonist and a 4-1bb agonist for treating cancer
Merck Sharp & Dohme Corp.
June 22, 2017 - N°20170174773

The present disclosure describes combination therapies comprising an antagonist of programmed death 1 receptor (pd-1) and a selective 4-1 bb agonist, and the use of the combination therapies for the treatment of cancer, and in particular for treating cancers that express pd-l1.
Methods of treating nail and scalp psoriasis
Kirin-amgen, Inc.
June 22, 2017 - N°20170174772

The present invention relates to a therapeutic agent for nail and scalp psoriasis comprising an il-17 receptor a (il-17ra or il-17r) antigen binding proteins, such as monoclonal antibodies that bind il-17ra, and method of using the same.
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Fgf21 receptor agonists and uses thereof
Regeneron Pharmaceuticals, Inc.
June 22, 2017 - N°20170174769

The present invention provides agonists of fgf21 signaling. In particular, the present invention provides fgf21 receptor (fgf21r) agonists that are capable of simultaneously binding βklotho (klb) and/or fgfr1c to mimic the signaling activity of fgf21. The present invention also provides anti-fgf21 and anti-klb/fgfr1c antibodies and antigen-binding fragments thereof. Also provided are methods of ...
T-cell receptor cdr3 peptides and antibodies
Yeda Research And Development Co. Ltd.
June 22, 2017 - N°20170174764

The present invention provides isolated peptides derived from tcr cdr3 segments, antibodies which recognize them, pharmaceutical compositions comprising them and methods of their use for modulating self-immunity.
Nogo receptor-mediated blockade of axonal growth
Yale University
June 22, 2017 - N°20170174763

Disclosed are ngr proteins and biologically active nogo (ligand) protein fragments. Also disclosed are compositions and methods for modulating the expression or activity of the nogo and ngr protein. Also disclosed are peptides which block nogo-mediated inhibition of axonal extension. The compositions and methods of the invention are useful in the treatment of cranial or cerebral trauma, spinal cord injury, ...
Combinatorial gamma 9 delta 2 t cell receptor chain exchange
Gadeta B.v.
June 22, 2017 - N°20170174741

The current invention provides methods to identify γ9δ2t-cell receptors (γ9δ2tcr) that mediate anti-tumour responses. Surprisingly, it was now found that the cdr3 regions of the γ9-t-cell receptor chain and the δ2-t-cell receptor chain micr chain) are of importance. Based on these findings, combinatorial-γδtcr-chain-exchange (...
Dr6 receptor mediates the leukemia differentiation activity of angiocidin: a potent anti-tumor peptide
Temple University-of The Commonwealth System Of Higher Education
June 22, 2017 - N°20170174734

The present invention provides compositions and methods of treating cancer by inducing the cellular differentiation activity of angiocidin.
Chagasin-based scaffold compositions, methods, and uses
Genentech, Inc.
June 22, 2017 - N°20170174733

Provided are novel, non-naturally occurring chagasin scaffold proteins derived from chagasin or chagasin-like protease inhibitor proteins. Also provided are libraries of non-naturally occurring chagasin scaffold proteins and methods of using such libraries to generate non-naturally occurring chagasin scaffold proteins that specifically bind to a target ligand. The present invention further provides methods of using non-naturally occurring chagasin protein scaffold that ...
Processes for the preparation of oxytocin analogues
Hoffmann-la Roche Inc.
June 22, 2017 - N°20170174725

Provided herein is a process for the preparation of oxytocin receptor agonists that have the potential to be used for the treatment of neurological disorders.
Compounds that are s1p modulating agents and/or atx modulating agents
Biogen Ma Inc.
June 22, 2017 - N°20170174710

Compounds of formula (i) can modulate the activity of one or more s1p receptors and/or the activity of autotaxin (atx).
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