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Receptor

Receptor-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Detection method and kit
The European Union, Represented By The European Commission
February 15, 2018 - N°20180045731

Uses of ethyl 5,11-dihydroindolo[3,2-b]carbazole-6-carboxylate as a fluorescent ligand probe, preferably in a binding assay for quantitative analysis in combination with a recombinant aryl hydrocarbon receptor (ahr) protein. A method for detection or quantitative analysis of suspected aryl hydrocarbon receptor (ahr) ligands in a sample, the method comprising the steps of: (a) providing a sample possibly containing at ...
Mutant smoothened and methods of using the same
Universite Paris Diderot - Paris 7
February 15, 2018 - N°20180045729

The emergence of mutations in tyrosine kinases following treatment of cancer patients with molecular-targeted therapy represents a major mechanism of acquired drug resistance. Here, mutations in the serpentine receptor, smoothened (smo) are described, which result in resistance to a hedgehog (hh) pathway inhibitor, such as in medulloblastoma. Amino acid substitutions in conserved residues of smo maintain hh signaling, but result ...
High throughput sequencing of multiple transcripts
Board Of Regents, The University Of Texas System
February 15, 2018 - N°20180044726

The present disclosure generally relates to sequencing two or more genes expressed in a single cell in a high-throughput manner. More particularly, the present disclosure relates to a method for high-throughput sequencing of pairs of transcripts co-expressed in single cells (e. G., antibody vh and vl coding sequence) to determine pairs of polypeptide chains that comprise immune receptors.
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Reprogramming progenitor compositions and methods of use therefore
Salk Institute For Biological Studies
February 15, 2018 - N°20180044642

The invention generally features compositions comprising induced pluripotent stem cell progenitors (also termed reprogramming progenitor cells) and methods of isolating such cells. The invention also provides compositions comprising induced pluripotent stem cells (ipscs) derived from such progenitor cells. Induced pluripotent stem cell progenitors generate ipscs at high efficiency. In particular embodiments the invention is predicated upon increased expression of an ...
Ex vivo nk cell differentiation from cd34+ hematopoietic cells
Ipd-therapeutics B.v.
February 15, 2018 - N°20180044636

The present invention relates to the ex vivo differentiation of nk cells from cd34+ hematopoietic stem cells. Such nk cells and their progenitor cells can be used in therapies of a broad range of malignancies. In the present invention it is shown that il-12 modulates ex vivo nk cell differentiation. Specific, we achieved significantly higher expression of kir, cd16 and ...
Modified immunocyte, method for producing modified immunocyte and utilization thereof
Riken
February 15, 2018 - N°20180044631

A modified immunocyte: (1) which expresses an exogenous unmodified t cell receptor α-chain and an exogenous t cell receptor β-chain on the cell surface thereof; or (2) which contains a polynucleotide encoding a t cell receptor α-chain and a polynucleotide encoding a t cell receptor β-chain. Thus, a new tool whereby immunity can be ...
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Use of il-31ra monoclonal antibodies for antagonizing signal transduction in dorsal root ganglion cells
Zymogenetics, Inc.
February 15, 2018 - N°20180044426

Use of antagonists to il-31ra and osmrb are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include soluble receptors, antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.
Novel antibodies and uses thereof
Cantargia Ab
February 15, 2018 - N°20180044425

The present invention provides an antibody or an antigen-binding fragment thereof with binding specificity for human interleukin-1 receptor accessory protein (il1rap) wherein the antibody or antigen-binding fragment is capable of inhibiting to domain 3 of human il1rap. The invention further provides the use of such antibodies or an antigen-binding fragments in the treatment and/or diagnosis of cancers, such ...
Car-expressing cells against multiple tumor antigens and uses thereof
The Trustees Of The University Of Pennsylvania
February 15, 2018 - N°20180044424

The invention provides compositions and methods for treating cancer by using immune effector cells (e. G., t cells, nk cells) engineered to conditionally express an agent which enhances the immune effector response of an immune effector cell that expresses a chimeric antigen receptor (car). The conditional agents described herein include agents that target a cancer associated antigen, e. G., a ...
Treatment of cancer using a cd33 chimeric antigen receptor
The Trustees Of The University Of Pennsylvania
February 15, 2018 - N°20180044423

The invention provides compositions and methods for treating diseases associated with expression of cd33. The invention also relates to chimeric antigen receptor (car) specific to cd33, vectors encoding the same, and recombinant t cells comprising the cd33 car. The invention also includes methods of administering a genetically modified t cell expressing a car that comprises a cd33 binding domain.
Combination of a pd-1 antagonist and vorinostat for treating cancer
Merck Sharp & Dohme Corp.
February 15, 2018 - N°20180044418

The present disclosure describes combination therapies comprising an antagonist of programmed death 1 receptor (pd-1) and suberoylanilide hydroxamic acid (saha), and the use of the combination therapies for the treatment of caner.
Chimeric antigen receptor (car) comprising a cd19-binding domain
Ucl Business Plc
February 15, 2018 - N°20180044417

There is provided a chimeric antigen receptor (car) comprising a cd19-binding domain which comprises a) a heavy chain variable region (vh) having complementarity determining regions (cdrs) with the following sequences: cdr1-gy-afsss (seq id no. 1); cdr2-ypgded (seq id no. 2) cdr3-sllygdyldy (seq id no. 3); and b) a light chain variable region (vl) having cdrs with the following sequences: ...
Polymeric fc proteins and methods of screening to alter their functional characteristics
Ucb Biopharma Sprl
February 15, 2018 - N°20180044416

The invention relates to polymeric fc proteins which bind to human fc-receptors and methods of screening said polymeric fc proteins to alter their functional characteristics. The invention also relates to therapeutic compositions comprising the polymeric fc proteins, and their use in the treatment of immune disorders.
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Fc fusion high affinity ige receptor a-chain
February 15, 2018 - N°20180044402

A linker fragment region between the (i) and the (ii) is the amino acid sequence shown in seq id no: 2.
Inhibitory chimeric antigen receptors
Cellectis
February 15, 2018 - N°20180044399

The invention relates to an inhibitory chimeric antigen receptor (n-car) comprising an extracellular domain comprising an antigen binding domain, a transmembrane domain, and, an intracellular domain wherein the intracellular domain comprises an immunoreceptor tyrosine-based switch motif itsm, wherein said itsm is a sequence of amino acid tx1yx2x3x4, wherein x1 is an amino acid x2 is an amino ...
Stable, protracted glp-1/glucagon receptor co-agonists for medical use
Novo Nordisk A/s
February 15, 2018 - N°20180044394

The invention relates to novel stable and protracted glp-1/glucagon receptor co-agonists, to the use of said peptides in therapy, to methods of treatment comprising administration of said peptides to patients, and to the use of said peptides in the manufacture of medicaments.
Codon optimized il-15 and il-15r-alpha genes for expression in mammalian cells
February 15, 2018 - N°20180044392

The present invention further provides expression vectors, and il-15 and il-15 receptor alpha combinations (nucleic acid and protein) that increase il-15 stability and potency in vitro and in vivo. The present methods are useful for the increased bioavailability and biological effects of il-15 after dna, rna or protein administration in a subject (e. G. A mammal, a human).
Asymmetric ureas and medical uses thereof
Helsinn Healthcare Sa
February 15, 2018 - N°20180044293

Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the ghrelin receptor. The compounds have the general formula (i):
Methods and compounds useful in the synthesis of orexin-2 receptor antagonists
Eisai R&d Management Co., Ltd.
February 15, 2018 - N°20180044285

The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.
Automated receptor system
Siemens Aktiengesellschaft
February 15, 2018 - N°20180044141

Provided is an automated receptor system of a sling-receiving element for gripping a connection device of a sling of a blade gripping device for gripping a rotor blade, in particular a rotor blade of a wind turbine, which automated receptor system includes a receptor for connecting the connection device to the sling-receiving element and a drive system for pivoting the ...
Spark plug storage device
February 15, 2018 - N°20180044061

A storage device for storing and transporting a plurality of spark plugs is disclosed. The storage device comprises a generally rectangular container comprising an open upper section and a storage rack. The storage rack comprises a generally rectangular box frame and a plurality of spark plug receptors positioned within the box frame along predetermined positions via support plates that extend ...
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