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Receptor

Receptor-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Perceptions in a haptic system
Ultrahaptics Ip Ltd
April 12, 2018 - N°20180101234

A system providing various improved perceptions techniques for haptic feedback above interactive surfaces that require no contact with either tools, attachments or the surface itself is described. A range of receptors in a perceiving member which is part of the human body is identified to create substantially uniformly perceivable feedback. A vibration frequency that is in the range of the ...
Protein binding domains stabilizing functional conformational states of gpcrs and uses thereof
The Board Of Trustees Of The Leland Stanford Junior University
April 12, 2018 - N°20180100865

The present invention relates to the field of gpcr structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a g-protein-coupled receptor (gpcr). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational ...
Functional characterization of immune repertoires
California Institute Of Technology
April 12, 2018 - N°20180100863

Provided herein are method and kits for elucidation of immunological repertoires (comprising functional pairs of immune cell receptors and antigens). In some embodiments, an immune cell receptor and an antigen that it binds to are isolated, and sequence information is obtained about the immune cell receptor and antigen. In some embodiments, an antigen expressed on a first cell and an ...
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Graphene oxide-based nanolab and methods of detecting of exosomes
Kansas State University Research Foundation
April 12, 2018 - N°20180100853

A capture device for capturing a biological substance can include: a substrate; a graphene-oxide layer on the substrate; at least one polydopamine polymer coupled with the graphene-oxide; and at least one targeting receptor coupled to the polydopamine(s), wherein the targeting receptor is capable of targeting/binding with a target biological substance. The graphene-oxide may be covalently coupled with the ...
Methods for treating and diagnosing cushing's syndrome
Corcept Therapeutics, Inc.
April 12, 2018 - N°20180100179

Methods are provided for assessing a clinical response to a glucocorticoid receptor antagonist (gra) in a human subject and for diagnosing cushing's syndrome.
Reduction of tgf beta signaling in myeloid cells in the treatment of cancer
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
April 12, 2018 - N°20180100157

Methods of inhibiting metastasis in cancer patients are provided, wherein the methods comprise reducing tgfβ signaling, for example, by reducing tgfβ receptor ii expression in myeloid cells. Vectors comprising a tgfβ receptor ii rnai nucleic acid sequence operably linked to a myeloid specific promoter also are provided. A method of diagnosing cancer in an ...
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Prostate-specific membrane antigen binding proteins and related compositions and methods
Aptevo Research And Development Llc
April 12, 2018 - N°20180100021

The present invention relates to mono-specific and multi-specific polypeptide therapeutics that specifically target cells expressing prostate-specific membrane antigen (psma) and are useful for the treatment of prostate cancer (e. G., castrate-resistant prostate cancer), tumor-related angiogenesis or benign prostatic hyperplasia (bph). In one embodiment, the multi-specific poly-peptide therapeutics bind both psma-expressing cells and the t-cell receptor complex on t cells to ...
Fgfr1 agonists and methods of use
Genentech, Inc.
April 12, 2018 - N°20180100018

The invention provides nucleic acid molecules encoding anti-fibroblast growth factor receptor-1 (fgfr1) antibodies and vectors and host cells comprising the nucleic acid molecules.
Use of car-modified human natural killer cells to treat cancer
April 12, 2018 - N°20180100016

The invention provides a natural killer cell, which may be a nk92 cell that is modified to express one or more types of chimeric antigen receptor (car) on its surface, and administering said cell to a subject for a cancer treatment. Said engineered car comprises an antigen binding domain, which may bind cd19 or gd2, a transmembrane domain, a co-stimulatory ...
Costimulatory b7-h1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic ...
Mayo Foundation For Medical Education And Research
April 12, 2018 - N°20180100015

The invention features methods of diagnosis by assessing b7-h1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with b7-h1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of b7-h1.
Novel peptides and combination of peptides for use in immunotherapy against various tumors
Immatics Biotechnologies Gmbh
April 12, 2018 - N°20180100005

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Composition and method for delivery of bmp-2 amplifier/co-activator for enhancement of osteogenesis
Brookhaven Science Associates, Llc
April 12, 2018 - N°20180100002

A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analogue is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.
Cognition enhancing compounds and compositions, methods of making, and methods of treating
Neurosolis, Inc.
April 12, 2018 - N°20180099956

The invention relates generally to muscarinic agonists, which are useful for stimulating muscarine receptors, and treating cognitive disorders. Included among the muscarinic agonists disclosed herein are oxadiazole derivatives, compositions, and preparations thereof. Methods of synthesizing oxadiazole compounds also are provided. This disclosure also relates in part to compositions for enhancing cognitive function in subjects such as humans, the compositions comprising ...
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Pyrrolidine gpr40 modulators
April 12, 2018 - N°20180099949

Or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are gpr40 g protein-coupled receptor modulators which may be used as medicaments.
Compounds and methods for the targeted degradation of androgen receptor
Arvinas, Inc.
April 12, 2018 - N°20180099940

The present disclosure relates to bifunctional compounds, which find utility to degrade and (inhibit) androgen receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the e3 ubiquitin ligase and on the other end a moiety which binds androgen receptor, such that androgen receptor is placed in proximity to ...
Process for the preparation of androgen receptor antagonists and intermediates thereof
Orion Corporation
April 12, 2018 - N°20180099938

The present invention relates to an improved process for the preparation of carboxamide structured androgen receptor (ar) antagonists such as n—((s)-1-(3-(3-chloro-4-cyanophenyl)-1h-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1h-pyrazole-3-carboxamide (1a) and key intermediates thereof such as 2-chloro-4-(1h-pyrazol-3-yl)benzonitrile (v). Ar antagonists are useful in the treatment of ...
Novel mhc-independent tumor-associated antigens
Universitaet Duisburg-essen
April 12, 2018 - N°20180099033

The present invention relates to novel tumor-associated antigens, which elicit independently from a presentation via mhc a cd8-positive t-cell response. Gm-csf-receptor alpha chain (csf2ra) and tyrosinase-related protein 2 (trp-2) were found to be targets of cd8-positive t-cell clones which could detect the proteins on the surface of hla i negative melanoma cells. Thus, the invention provides proteins, protein ...
Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists
U.s. Government As Represented By The Department Of Veterans Affairs
April 12, 2018 - N°20180099027

The present invention provides methods for preventing, attenuating neuronal damage or stimulating neuronal repair prior or following central nervous system injury.
Compositions and methods for managing weight
Unigen, Inc.
April 12, 2018 - N°20180099019

The present disclosure provides diels-alder adducts of chalcone and prenylphenyl moieties capable of modulating the activity of cannabinoid receptors, and to oligomers of flavan-3-ol capable of modulating fat absorption and storage. Such diels-alder adducts of chalcone and prenylphenyl moieties or oligomers of flavan-3-ol can optionally be used in combination with other weight management agents, such as anorectic agents, ...
Lasofoxifene treatment of breast cancer
Duke University
April 12, 2018 - N°20180098963

The disclosure provides methods for treating estrogen receptor positive (er+) cancer in women with an effective amount of lasofoxifene, a pharmaceutically acceptable salt thereof, or a prodrug thereof. The disclosure also includes the detection of the estrogen receptor 1 (esr1) gene mutations that lead to endocrine resistance and treatment of endocrine resistant er+ cancers.
Particles containing an opioid receptor antagonist and methods of use
University Of Chicago
April 12, 2018 - N°20180098947

Particles comprising an opioid receptor antagonist as well as methods of their use and methods of their preparation are provided herein. Such particles may be used for treating and preventing opioid-induced side effects in patients, and may be provided to chronic opioid users as well.
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