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 Image processing device and storage medium for image processing patent thumbnailImage processing device and storage medium for image processing
An image processing device inputs a bright field linage of a tissue slice in which a cell nucleus is stained and a fluorescent image of the tissue slice in which a specific biological substance is stained with a fluorescent staining reagent (s10), extracts a cell nucleus from the image of the cell nucleus (s20), extracts a fluorescent bright point from the fluorescent image (s30), specifies a cell nucleus to which the fluorescent bright point is assigned on the basis of the distance between the cell nucleus and the fluorescent bright point, and assigns the fluorescent bright point with the cell nucleus (s40).. .
Konica Minolta, Inc.


 Plate hanging device and alignment film coating system patent thumbnailPlate hanging device and alignment film coating system
The invention provides a plate hanging device and an alignment film coating system. The plate hanging device includes a plate hanging part and a control part, wherein the plate hanging part is used for keeping the part of a transfer plate not coiled on a cylinder at a stretched state in a plate hanging process; the control part is used for controlling the cylinder to rotate to coil the transfer plate on the surface of the cylinder, the plate hanging device further includes a liquid spray part, the liquid spray part is connected with the control part and is controlled by the control part to uniformly spray a chemical reagent onto the surface to be jointed of the transfer plate to increase the friction between the transfer plate and the cylinder, and the surface to be jointed is a surface to be jointed with the cylinder of the transfer plate..
Ordos Yuansheng Optoelectronics Co., Ltd.


 Sample analyzer patent thumbnailSample analyzer
The sample analyzer includes: a reagent arranging section for arranging a plurality of reagents; an analyzing section for analyzing a measurement sample prepared by mixing a sample and the reagent arranged on the reagent arranging section; a display device; an input device; and a display control section for displaying a reagent arrangement displaying region for displaying a plurality of reagent marks inscribed with a reagent name respectively on the display device, wherein the each reagent mark is displayed in a manner selectable by the input device, wherein arrangement of the each reagent mark on the reagent arrangement displaying region corresponds to arrangement of the each reagent on the reagent arranging section, wherein the display control section displays detailed information related to the reagent corresponding to the reagent mark selected by the input device on the display device.. .
Sysmex Corporation


 Automatic analysis device and analysis method patent thumbnailAutomatic analysis device and analysis method
A signal reference value (slocal) is set at which a blood coagulation reaction time (t) of a blood coagulation time reference sample measured on the basis of the result of comparing a signal value (amount of transmitted light, amount of scattered light, amount of fluorescence, or turbidity) pertaining to blood coagulation time that varies temporally according to the mixing and reaction of the blood coagulation time reference sample and a reagent and a signal reference value (s) corresponds to an expected value (te) for the blood coagulation reaction time that has been set beforehand so as to correspond to the blood coagulation time reference sample. As a result, it is possible to use the blood coagulation time reference sample to determine the state of the reagent and enhance the reliability of measurement results by setting a unique signal reference value for each reagent container..
Hitachi High-technologies Corporation


 Method for measurement of hba1c using amadoriase that reacts with glycated peptide patent thumbnailMethod for measurement of hba1c using amadoriase that reacts with glycated peptide
This invention provides an amadoriase that can react with a wide variety of glycated peptides generated upon hydrolysis of the β chain of hemoglobin alc (hbalc) to generate hydrogen peroxide, a method for measurement of hbalc using such amadoriase, and a reagent kit for measurement of hbalc using such amadoriase. Provided is an amadoriase obtained by substitution of one or more amino acids at positions corresponding to amino acids selected from the group consisting of amino acids 62, 63, 102, 106, 110, 113, and 355 in the amino acid sequence of the amadoriase derived from the genus coniochaeta or the like which amadoriase is capable of oxidizing a wide variety of glycated peptides to generate hydrogen peroxide.
Kikkoman Corporation


 Multiplex mrm assay for evaluation of cancer patent thumbnailMultiplex mrm assay for evaluation of cancer
The current disclosure provides specific peptides, and derived ionization characteristics of the peptides from the estrogen receptor (er), progesterone receptor (pr), and/or antigen ki67 (ki67) proteins that are particularly advantageous for quantifying the er, pr, and/or ki67 proteins directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring/multiple reaction monitoring (srm/mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.


 Fluorescent-hap: a diagnostic stain for hbv cores in cells patent thumbnailFluorescent-hap: a diagnostic stain for hbv cores in cells
Heteroaryldihydropyrimidine (hap)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery are described. The present invention relates to heteroaryldihydropyrimidine (hap)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery..
Indian University Research And Technology Corporattion


 Lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same patent thumbnailLateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same
Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region..
President And Fellows Of Harvard College


 Zwitterionic reagents patent thumbnailZwitterionic reagents
Zwitterion-containing compounds for the modification of hydrophobic molecules to improve their solubility and/or to lower their non-specific binding as provided. The zwitterion-containing compounds may be suitable for modification of detectable labels such as biotin and fluorescein to improve their solubility.
Siemens Healthcare Diagnostics Inc.


 Skin-print fluorescence analysis method and apparatus patent thumbnailSkin-print fluorescence analysis method and apparatus
A method of analysing a skin-print provided on a first surface of an optically transparent substrate. The method comprises the steps of exposing the skin-print on the first surface of the optically transparent substrate to one or more reagents selected to bind with one or more metabolites present in the skin-print; transmitting electromagnetic radiation onto the skin-print through the optically transparent substrate using a radiation source to thereby produce an optical signal of said one or more reagents and/or said one or more metabolites; and detecting an optical image of the optical signal through the optically transparent substrate using a sensor.
Intelligent Fingerprinting Limited


Insulin assay


Provided herein is a human insulin latex agglutination immunoassay and assay reagents with which nonspecific reaction in a blood sample assay can be suppressed. The assay performs an immunoreaction with anti-insulin antibody-immobilized particles in a buffer containing two or more amine compounds having a ph buffering effect..
Sekisui Medical Co., Ltd.


Integrated and standalone label and reagent-free microfluidic devices and microsystems for differential white blood cell counts


A method of establishing a differential white blood cell count includes directing at least one stream of deionized water into a microfluidic device containing a sample of whole blood or a cell-rich fraction to generate a lysate stream of intact white blood cells; directing at least one stream of deionized water into the lysate stream to form a virtual non-conductive aperture in a channel of the device; and performing impedance cytometry of the lysate stream via coplanar electrodes to detect the presence of intact white blood cells. A microfluidic device includes a blood separation section.
University Of Maryland


In situ heat induced antigen recovery and staining apparatus and method


Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments for individually and independently processing a plurality of individual microscope slides. The apparatus preferably features independently movable slide support elements each having an individually heatable heating plate.

Method of determining an analyte concentration


A reagent composition for a biosensor sensor strip is disclosed that provides for rapid rehydration after drying. The composition includes porous particles and is preferably formed as a colloidal suspension.
Ascensia Diabetes Care Holdings Ag


Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same


The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low action on maltose. The present invention relates to a polynucleotide encoding a soluble coenzyme-linked glucose dehydrogenase that catalyzes the oxidation of glucose in the presence of an electron acceptor and has an activity toward maltose of 5% or lower; a polypeptide encoded by the nucleotide sequence of the polynucleotide; a recombinant vector carrying the polynucleotide; a transformed cell produced using the recombinant vector; a method for producing a polypeptide comprising culturing the transformed cell and collecting from the cultivated products a polypeptide that links to fad to exert the glucose dehydration activity; a method for determination of glucose using the polypeptide; a reagent composition for determination of glucose; and a biosensor..
Ikeda Food Research Co., Ltd.


Method of measuring blood component amount


A method for measuring a blood component amount uses a biosensor to calculate a blood component amount in blood. The biosensor includes the following: a first electrode system having a first working electrode and a first counter electrode; a second electrode system having a second working electrode and a second counter electrode; and a reagent portion arranged in a form that covers at least a part of the first electrode system, but does not cover the second working electrode.

Apparatus and closed system recovery of cells from tissue samples


A closed system apparatus and method for isolation and recovery of desired cells from body tissue includes a first container for tissue dissociation by subjection to centrifugation over one or more cycles of rotational acceleration and deceleration, a particle filter to filter out non-dissociated tissue while passing desired cells to a second container for separating the desired cells from connective tissue, unwanted material, liquid, and dissociation-aiding reagent(s) by subjection of the second container to combined centrifugal and gravitational forces that also causes concentration and sedimentation of the cells into a pellet for removal through a valve in the bottom of the second container.. .
Ingeneron Incorporated


Sorbic acid ester containing coatings composition


The present invention is a composition comprising a solution or a dispersion of polymer particles, a sorbate ester or sorbamide curing agent, and a cure modulating additive for the curing agent. The curing agent is a sorbic acid ester or a sorbamide and the cure modulating agent is a reagent capable of accelerating or attenuating the rate of cure of the curing agent.
Rohm And Haas Company


Ziegler-natta catalysts doped with non-group iv metal chlorides


A process may include contacting ethylene monomer with ziegler-natta catalyst to form polyethylene. The ziegler-natta catalyst may be formed by contacting an alkyl magnesium compound with an alcohol and a metal reagent to form a blend, and contacting the blend with a first agent to form a solution of reaction product “a”.
Fina Technology, Inc.


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Antibodies for tumor gangliosides


High affinity antibodies were made to gangliosides expressed on tumor cells. The antibodies can be used analytically, diagnostically, therapeutically, and theranostically.
The Government Of The United States As Represented By The Secretary Of Health


Novel reagents for universal site-specific labeling and modifications of nucleic acids


The present invention discloses a method of harnessing versatile phosphoramidation reactions to regioselectively incorporate alkynyl/azido groups into post-synthetic nucleic acids primed with phosphate at the 5′ termini. With and without the presence of copper, the modified nucleic acids were subjected to azide-alkyne cycloaddition to obtain various nucleic acid conjugates including a peptide-oligonucleotide conjugate (poc) with a high yield..
Kaohsiung Medical University


Highly fluorescent pyrrole-bf2 chromophores


Fluorescent chromophores nicknamed bophy are provided. The chromophores may be readily synthesized in two steps from readily available reagents via the coupling of a pyrrole aldehyde or ketone with hydrazine, followed by reaction with bf3.

Methods for preparing brexpiprazole, key intermediates thereof and salts thereof


The present invention relates to the methods for preparing brexpiprazole, the analogs, key intermediates, and salts thereof, specifically, the present invention relates to a new method for preparing brexpiprazole, the analogs, key intermediates, and salts thereof, and the key intermediates, and salts thereof provided during the preparation. The preparation method has a mild reaction condition, stable intermediate, easy operation, and uses cheap and easy-to-get reagents, thus it saves the synthesis cost, shortens the production cycle, improves the yield and product quality, and is suitable for mass production..
Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences


Preparation dexmedetomidine intermediate


The present invention discloses a preparation method of 2,3-dimethyl phenyl-1-trityl-imidazole-4-ketone. In accordance with this method, imidazole-4-ethyl formate is used as a raw material; ethyl formate is used for amino protection, 1-trityl-1h-imidazole-4-formic acid is obtained after basic hydrolysis; 1-trityl-1h-imidazole-4-formic acid and n,o-dimethylhydroxylamine hydrochloride are subjected to condensation so as to obtain n-methoxyl-n-methyl-1-trityl-1h-imidazole-4-formamide; and n-methoxyl-n-methyl-1-trityl-1h-imidazole-4-formamide and a grignard reagent prepared by the reaction of 2,3-dimethylbromobenzene with magnesium are subjected to a grignard reaction, and then the target product 2,3-dimethyl phenyl-1-trityl-1h-imidazole-4-ketone is obtained.
Tianjin Weijie Pharmaceutical Co., Ltd


Fluorination of organic compounds


Methods for fluorinating organic compounds utilizing a novel organic reagent are described herein. The invention further discloses the utility of this reagent for incorporation of the 18 f isotope into hydroxyl group-containing organic molecules for pet imaging studies.
President And Fellows Of Harvard College


Flotation reagents and flotation processes utilizing same


Methods of enhancing recovery of value sulfide or precious minerals from an ore containing mg-silicate, slime forming minerals, and/or clay by subjecting the ore to a flotation process performed under acidic conditions, in conjunction with the addition of a froth phase modifier agent to the ore, are provided herein.. .
Cytec Technology Corp.


Triorthogonal reagents for dual protein conjugation


The present invention relates to triorthogonal reagents useful for site-specifically modifying a protein with two orthogonal groups that can be subsequently functionalized in a single one-pot procedure. This approach relies on the selective tagging of proteins containing an appended farnesyltransferase or geranylgeranyltransferase i substrate sequence.
Regents Of The University Of Minnesota


Use of ginsenoside-rg3 in preparing medicine for preventing or/and treating dementia and medicine


The present invention discloses an application of ginsenoside rg3 in preparing a medicine or product for preventing and treating dementia, and a preparation method thereof, which belong to the fields of medicines and health care products, and its products comprise a topical preparation, oral preparation and injection of the ginsenoside rg3; and the rg3 medicine or formulating prepared rg3 compound medicine is prepared by using a solubilizer, a transdermal agent, a reagent promoting the absorption by penetrating a blood-brain barrier and an extractive, achieving the effect that the medicine penetrates the blood-brain barrier, and is used for preventing and treating dementia.. .

Charge-stripping of multiply-charged ions


A method of mass spectrometry or ion mobility spectrometry is disclosed wherein a sample is ionised by an electrified sprayer so as to produce multiply charged analyte ions of a first polarity in gas-phase. A reaction region is provided downstream of the electrified sprayer, wherein the reaction region is maintained substantially at atmospheric pressure and is maintained substantially free of electric-fields.
The University Of British Columbia


Analysis device and reagent container


An analysis device for particle analysis, configured in such a manner that a reagent container is set in the device by inserting the reagent container from a side surface of the device toward the inside thereof, the reagent container having, near the forward end thereof, a suction pipe entrance portion into which a suction pipe can enter. The analysis device is provided with: a reagent container holding portion which holds the reagent container inserted from the suction pipe entrance portion side; and the suction pipe which enters, from above, the suction pipe entrance portion of the reagent container held by the reagent container holding portion and which sucks a reagent within the reagent container.
Sysmex Corporation


Reagent container anti-evaporation tube


An anti-evaporation tube for use with an in vitro diagnostics automation system is provided. The anti-evaporation tube includes an anti-evaporation tube body configured to be automatically inserted in a container and to limit evaporation of one or more fluids in the container and an alignment portion disposed on the anti-evaporation tube body.
Siemens Healthcare Diagnostics Inc.


Multi-well wedge-shaped reagent container with auto-open capability


A multi-well fluid container that includes a container body is provided for use in an in vitro diagnostics automation system. The container body includes a first well having a first well size configured to hold a first fluid and an openable first well closure that covers a first well opening.
Siemens Healthcare Diagnostics Inc.


Methods and compositions of non-enzymatic amplification and direct detection of nucleic acids


The detection and quantification of nucleic acid sequences can be done using template catalyzed tara transfer reactions without enzyme and pcr. It comes with the novel chemistry platform technology using template assisted rapid assay (tara), an enzyme-free, pcr-less and rapid transfer reaction assay directly from samples from nasopharyngeal swab, nasal aspirate, oropharyngeal swab or blood.
Crosslife Technologies Inc.


Compositions and methods for diagnosing and/or treating influenza infections


The present invention provides ha polypeptides (e.g., h1 ha polypeptides) that bind to umbrella-topology glycans, and reagents and methods relating thereto. The present invention provides binding agents that bind to ha polypeptides (e.g., h1 ha polypeptides), and reagents and methods relating thereto.
Massachusetts Institute Of Technology


Enhanced capture of magnetic microbeads in microfluidic devices using sequentially switched electroosmotic flow


Methods of increasing the capture efficiency of a microfluidic device for a target reagent, without additional complications to the design of existing microfluidic devices, and more particularly methods of increasing the capture efficiency of a microfluidic device for magnetic microbeads within a microfluidic channel using sequentially switched electroosmotic flows.. .
University Of Cincinnati


Composition comprising up-converting phosphors for detecting an analyte


The present invention relates to a detector matrix for detecting at least one analyte in a sample, preferably a sample of a body fluid, comprising at least one enzyme active in the presence of said at least one analyte and at least one indicator reagent changing at least one optical property dependent on the activity of said enzyme, wherein said detector matrix further comprises up-converting phosphor particles, preferably uv-emitting up-converting phosphor particles. The invention further relates to a test element and a test device for detecting at least one analyte in a sample comprising the detector matrix of the invention, as well as to a method for the manufacture of a detector matrix, a method for the manufacture of a test element, and to a method for detecting an analyte in a sample, comprising contacting a detector matrix according to the invention with a sample suspected to comprise said analyte..
Roche Diabetes Care, Inc.


Formaldehyde test reagent


An aqueous test reagent for detection of formaldehyde. The reagent comprises acetylacetone; ammonia, a c1-c4 primary amine or salts thereof; and a c4-c8 aliphatic organic dicarboxylic or tricarboxylic acid..
Dow Global Technologies Llc


Tyrp1, a natural mirna sponge, and its use in managing human melanoma aggressiveness


The present invention relates to methods and reagents for the treatment of melanoma and/or of metastatic melanoma that directly or indirectly target tyrp1 rna transcript. The invention also relates to methods for predicting if a melanoma patient will be therapeutically responsive to such methods of treatment and reagents, and to methods for assessing the effectiveness of such methods of treatment and reagents.
Centre Hospitalier Universitaire Pontchaillou


Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof


The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual having a cardiovascular disorder to treatment of the disorder with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
Celera Corporation


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Portable testing device for analyzing biological samples


A portable testing device includes a housing with an integrated touchscreen display and a receptacle in which a sample holder containing a biological sample and reagent mixture can be placed. The portable testing device further includes an optical assembly positioned in the housing, an electronic assembly that is configured to receive data from the optical assembly and transmit it for display on the touchscreen display, and a power supply in the housing to power the portable testing device.
Douglas Scientific, Llc


Nucleic acid ligand diagnostic biochip


A nucleic acid ligand “biochip” is disclosed, consisting of a solid support to which one or more specific nucleic acid ligands is attached in a spatially defined manner. Each nucleic acid ligand binds specifically and avidly to a particular target molecule contained within a test mixture, such as a bodily fluid.
Somalogic, Inc.


Methods for detecting nucleic acids


Disclosed herein are methods for detecting a target nucleic acid molecule in a sample. The methods can include contacting a sample with a detectably labeled probe (detection probe) that specifically binds to a first target sequence in the target nucleic acid molecule, a bifunctional oligonucleotide including a portion that specifically binds to a second target sequence in the target nucleic acid molecule and a portion that specifically binds to an anchor, and a surface comprising the anchor.
Htg Molecular Diagnostics, Inc.


Portable dna analysis machine


Aspects of the present disclosure relate to dna amplification systems, e.g., pcr chips used to hold a testing solution and sample, and systems and methods for testing the sample including thermocycling and detection. The system can include a containment chip capable of holding a sample and reagents for amplifying a nucleic acid in the sample and containing a unique identifier used to choose a nucleic acid amplification protocol.
Hexna Corp.


Lactate dehydrogenase detector


A lactate dehydrogenase detector, which is used to detect a content of lactate dehydrogenase in a biological sample, comprises a substrate, an electrode assembly, a hydrophobic insulation layer, a cover and a reagent-containing membrane. The electrode assembly is disposed on the substrate and including a working electrode and a reference electrode.
Eumed Biotechnology Co., Ltd.


Blood culture bottles with mechanisms for controlled release of substances into culture media


An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200.
Becton, Dickinson And Company


Mispriming prevention reagents


Provided herein are mispriming prevention reagents, compositions and kits comprising such reagents and methods of use thereof.. .
Brandeis University


Reagents for lysis of bacterial cells


The invention provides a composition containing an aqueous liquid phase, bacterial cells, and an ionic compound dissolved in the liquid phase. The ionic compound is selected from the group consisting of 1-butyl-3-methyl-imidazolium-thiocyanate, 1-butyl-3-methyl-imidazolium-2(2-methoxy-ethoxy)ethylsulfate, 1-methyl-1-[4-(3-methyl-3h-imidazol-1-ium)-but-1-yl]-3h-imidazolium-di(toluylsulfate), and 1-butyl-3-methyl-imidazolium-octylsulfate.
Roche Diagnostics Operations, Inc.


Methods and apparatuses for droplet mixing


Methods and systems are provided for merging a droplet with a volume of fluid in a microfluidic system. In particular, the methods of the invention use a microfluidic structure designed to merge a fluid with a droplet in order to dilute, add volume, or add selected reagents, biological materials, or synthetic materials to a droplet.
Gigagen, Inc.


Particulate aggregating and surface modification with improved hydrocarbon fluid flow through the aggregated particulates and over solid surface reagents and methods for making and using same


Composition and methods using the compositions are disclosed, where the compositions include heterocyclic aromatic amines, substituted heterocyclic aromatic amines, poly vinyl heterocyclic aromatic amines, co-polymers of vinyl heterocyclic aromatic amine and non amine polymerizable monomers (ethylenically unsaturated mononers and diene monomers), or mixtures or combinations thereof reacted with sulfonic acids, alkyl sulfonic acids, sulfosuccinates, sulfamic acids, sulfuric acids or partially neutralized amine or other alkali sulfonate and/or reacted with alpha hydroxyl carboxcylic acids which form coatings that alter self-aggregating properties and/or aggregation propensities of the particles and surfaces. Furthermore, the coating can be used to improve filtration of fluids through particulate matter and it is found that the coating will increase hydrocarbon liquid and gas flow through or over treated particulates and surfaces..
Sumisaujana Tcm Chemicals Sdn. Bhd.


Particulate aggregating and surface modification with improved hydrocarbon fluid flow through the aggregated particulates and over solid surface reagents and methods for making and using same


Composition and methods using the compositions are disclosed, where the compositions include heterocyclic aromatic amines, substituted heterocyclic aromatic amines, poly vinyl heterocyclic aromatic amines, co-polymers of vinyl heterocyclic aromatic amine and non amine polymerizable monomers (ethylenically unsaturated mononers and diene monomers), or mixtures or combinations thereof reacted with sulfonic acids, alkyl sulfonic acids, sulfosuccinates, sulfamic acids, sulfuric acids or partially neutralized amine or other alkali sulfonate and/or reacted with alpha hydroxyl carboxcylic acids which form coatings that alter self-aggregating properties and/or aggregation propensities of the particles and surfaces. Furthermore, the coating can be used to improve filtration of fluids through particulate matter and it is found that the coating will increase hydrocarbon liquid and gas flow through or over treated particulates and surfaces..
Sumisaujana Tcm Chemicals Sdn. Bhd.


Particulate aggregating and surface modification with improved hydrocarbon fluid flow through the aggregated particulates and over solid surface reagents and methods for making and using same


Composition and methods using the compositions are disclosed, where the compositions include heterocyclic aromatic amines, substituted heterocyclic aromatic amines, poly vinyl heterocyclic aromatic amines, co-polymers of vinyl heterocyclic aromatic amine and non amine polymerizable monomers (ethylenically unsaturated mononers and diene monomers), or mixtures or combinations thereof reacted with sulfonic acids, alkyl sulfonic acids, sulfosuccinates, sulfamic acids, sulfuric acids or partially neutralized amine or other alkali sulfonate and/or reacted with alpha hydroxyl carboxcylic acids which form coatings that alter self-aggregating properties and/or aggregation propensities of the particles and surfaces. Furthermore, the coating can be used to improve filtration of fluids through particulate matter and it is found that the coating will increase hydrocarbon liquid and gas flow through or over treated particulates and surfaces..
Sumisaujana Tcm Chemicals Sdn. Bhd.


Method for producing peptide hydrazide, peptide amide, and peptide thioester


Wherein r1, r2, r3, and x are as defined in the specification, and using a hydrazine compound or an ammonia compound as a reaction reagent. The present invention also provides a method for producing a peptide thioester compound from the peptide hydrazide compound..

Method for producing a blank from titanium- and fluorine-doped glass having a high silicic-acid content


A method for producing a blank from titanium-doped, highly silicic-acidic glass having a specified fluorine content for use in euv lithography is described, in which the thermal expansion coefficient over the operating temperature remains at zero as stably as possible. The course of the thermal expansion coefficient of ti-doped silica glass depends on a plurality of influencing factors.
Heraeus Quarzglas Gmbh & Co. Kg


System and movement and timing control


The present invention relates to fluidic systems for controlling one or more fluids and/or one or more reagents. These systems can be used in combination with one or more devices for assaying, processing, and/or storing samples.
Slipchip Corporation


Reagent vessel holder for an analytical instrument, reagent supply system for an analytical instrument and an analytical instrument


A reagent vessel holder for an analytical instrument is disclosed. The reagent vessel holder comprises at least one reagent vessel compartment for receiving a reagent vessel, wherein the reagent vessel compartment comprises a base and at least two lateral guiding elements, and at least one hollow needle for piercing the reagent vessel.
Hitachi High-technologies Corporation


Device and handling reagents


A device, especially a microfluidic device for performance of an immunoassay, has a first, a second and a third fluidically connected chamber and a membrane. In the event of a given deflection of the membrane into the first chamber, a first fluid is passed at least partly out of the first chamber into the second chamber in such a way that a second fluid is at least partly displaced from the second chamber into the third chamber in such a way that the third chamber is entirely filled with the second fluid..
Robert Bosch Gmbh


Methods, systems and compositions relating to cell conversion via protein-induced in-vivo cell reprogramming


Methods for treating a subject in need thereof are provided which include administering a pharmaceutical composition comprising a protein transduction reagent-modified reprogramming protein to the subject, wherein the protein transduction reagent is non-covalently bound to the reprogramming protein and wherein the protein transduction reagent comprises a cation reagent and a lipid. According to aspects, such methods provide delivery of protein-transduction reagent-modified reprogramming proteins to cancer cells, such as tumor cells, as well as diseased cells of diseased tissues and provide in vivo conversion of diseased cells into normal cells via protein-induced in situ cell reprogramming without administration of nucleic acids to the subject..
Wayne State University


Reagent for enhancing generation of chemical species and manufacturing apparatus


A reagent that enhances acid generation of a photoacid generator and composition containing such reagent is disclosed.. .
Toyo Gosei Co., Ltd.


Methods and measuring aspiration pressure


An aspiration apparatus adapted to allow aspiration verification of a liquid such as of a biological liquid or reagent liquid, especially at low aspiration volumes (e.g., less than 25 μl). The apparatus includes a pump operable at an operating frequency, the pump optionally including a pumping chamber, a probe having a probe interior, a main supply line containing a backing liquid coupled to and extending from the pump and including the probe interior, a striction coupled to the main supply line, or the pump chamber, if present, and a reservoir fluidly coupled to the striction, wherein the striction is sized to minimize backing liquid flow through the striction at one or more disturbance frequencies above the operating frequency.
Siemens Healthcare Diagnostics Inc.


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Use of markers including filamin a in the diagnosis and treatment of prostate cancer


Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including the detection of levels of variety of biomarkers diagnostic of prostate cancer, including filamin a alone, or in combination with one or more additional biomarkers of prostate cancer, including, psa, keratin 4, keratin 7, keratin 8, keratin 15, keratin 18, keratin 19, tubulin-beta 3, filamin b, and ly9. Additionally, age can be used as a predictor variable.
Berg Llc


Antigen-coupled immunoreagents


The present disclosure provides high-performance immunoreagents for use in a variety of immunologic assays and other related techniques. The immunoreagents comprise a primary antibody and a bridging antigen, wherein the bridging antigen is recognized by a detectable secondary antibody with high affinity.
Cell Idx, Inc.


Integrated microreactor array system


A microreactor array system includes an array of microreactors, and a sealing membrane having a first surface and an opposite second surface, the sealing membrane configured to movably seal the array of microreactors. The microreactor array system further includes a reagent gap providing a fluid path between the array of microreactors and the second surface of the sealing membrane when the second surface of the sealing membrane is in spaced relationship with the array of microreactors.

Gas detector tube template and methods of reading gas detector tubes


Gas detector tube templates are described. Gas detector tubes may be used to determine the concentration of target gases in a sampled gas either visually or electronically.
Nextteq Llc


Hydrogel particles with tunable optical properties and methods for using the same


Hydrogel particles and their use in cytometic applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to the at least one optical property of a target cell.
Slingshot Biosciences


Methods for rapid ribonucleic acid fluorescence in situ hybridization


The present invention provides a method for improved fluorescent in situ hybridization (fish) methodology which allows for quantifiable signals to be obtained in a short period of time. In certain embodiments, the method provides for a shorter hybridization time, thereby allowing the present method to be used in screening and rapid diagnostic methods.
The Trustees Of The University Of Pennsylvania


Devices and formulations for detecting, screening and monitoring levels of certain constituents in bodily fluids and method


A device is disclosed for conducting a non-invasive analysis of a bodily fluid to determine the presence and level of a certain constituent carried by the bodily fluid. An indicator formulation of the device changes color in response to exposure to the constituent to provide a visible indication of the presence and level of the constituent carried by the bodily fluid.
Pop Test Llc


Foamy viral vector compositions and methods for the manufacture of same


Disclosed are methods of preparing fv vector particles. In some aspects, the disclosed methods may include the steps of transfecting a population of eukaryotic cells by contacting said population of eukaryotic cells with one or more transfection reagents to form a transfection mixture, and incubating the transfection mixture to form a transfected cell population; harvesting the fv vector particles from said transfected cell population; purifying the fv vector particles; and concentrating the fv vector particles..
Children's Hospital Medical Center


Antibody binding microbial heparin binding motif to retard or prevent microbial biofilm formation on implanted medical devices


Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as candida species and/or staphylococcus species.. .
Yale University


Immunogenic peptides of the cyclin b1 tumor antigen


The present invention relates to peptides comprising at least one cd4+ t epitope, which is immunodominant in vitro, of the cyclin b1 tumor antigen, said peptides being capable of stimulating a specific human cd4+ t lymphocyte response in subjects who have varied hla ii molecules, and to the use of these peptides as a cancer vaccine and as a reagent for the diagnosis of cancer or the immunomonitoring of the cellular response against cyclin b1 during cancer or during an anticancer treatment.. .
Commissariat A L'energie Atomique Et Aux Energies Alternatives


Systems and methods for treating non-point source pollutants in water runoff using slow-release agents


A slow-release method for treating non-point source pollutants traveling in water runoff, such as urban water runoff. Method embodiments include the use of slow-release advanced oxidation process forms (sr-aops) comprised of one or more water soluble salts in a matrix and/or forms producing hydrogen peroxide, persulfate anion, and/or permanganate.
Ohio University


Ms/ms analysis using ecd or etd fragmentation


A method of mass spectrometry is disclosed comprising: providing supercharged analyte ions; and supplying electrons or reagent ions to said analyte ions so as to transfer charge from said reagent ions or electrons to said analyte ions, said transfer of charge causing at least some of said analyte ions to dissociate. The charge transfer step is performed at a relatively high pressure and preferably substantially at atmospheric pressure..
Micromass Uk Limited


System and processing of biological tissue samples


The present disclosure provides an automated system for processing of tissue. The system comprises a plurality of containers for storing at least one of tissue samples, buffer solutions, enzymes and other reagents, tissue processing container for processing of the tissue, and a robotic assembly coupled to the tissue processing container.
Stempeutics Research Private Limited


Methodologies and reagents for detecting fibrinolysis and hyperfibrinolysis


In some embodiments, the invention provides a container adapted for detecting hyperfibrinolysis or fibrinolysis in a blood sample using viscoelastic analysis comprising an interior having a coating comprises an inhibitor of fibrinolysis.. .
The Regents Of The University Of Colorado, A Body Corporate


Cmet protein srm/mrm assay


Specific peptides are provided, and derived ionization characteristics of those peptides, from the hepatocyte growth factor receptor (cmet) protein. The peptides are particularly and surprisingly advantageous for quantifying by the method of selected reaction monitoring (srm) mass spectrometry the cmet protein directly in biological samples that have been fixed in formalin, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry.
Expression Pathology, Inc.


Competitive ligand binding assay for detecting neutralizing antibodies


A immunogenicity assay for detecting the presence of neutralizing antibodies to a biotherapeutic protein wherein the biotherapeutic protein has been administered to a patient in need, comprising the steps of (a) obtaining a sample from the patient; (b) incubating the sample in the presence of a capture reagent; and (c) adding a detecting reagent, wherein a decreased signal relative to a control sample indicates the presence of a neutralizing antibody to the biotherapeutic agent.. .
Regeneron Pharmaceuticals, Inc.


Quaternary amine containing isobaric tag for quantitative glycan profiling


The disclosure provides quaternary amine containing isobaric tag reagents useful in the analysis of biomolecules and methods of making and using the quaternary amine containing isobaric tag reagents. The quaternary amine containing isobaric tag reagents are particularly useful for glycan analysis, especially quantitative glycan profiling such as glycan quantitation by tandem mass spectrometry..
University Of Maryland, College Park


Assays for macromolecular analytes


A method of determining a macromolecular analyte in a sample suspected of containing the macromolecular analyte is disclosed. The sample and a conjugate reagent comprising a small molecule and a binding partner for the macromolecular analyte are combined in a medium.
Siemens Healthcare Diagnostics Inc.


Use of a reagent for the lysis of erythrocytes as well as methods and kits relating thereto


The present disclosure relates to use of a reagent for the lysis of erythrocytes, a method of lysing erythrocytes and a kit comprising the reagent.. .
Roche Diagnostics Operations, Inc.


Use of let-7g to down regulate ns5b gene, core protein and viral load of hepatitis c virus


A method for evaluating the therapeutic efficacy of interferon(ifn)/ribavirin(rbv) for hepatitis c is disclosed. The method includes the steps of providing a specimen; mixing the specimen, a primer of a mirna let-7g and a poly-chain reaction(pcr) reagent together; and evaluating the efficacy of ifn/rbv on inhibiting a hepatitis c virus according to the expressing level of the mirna let-7g in the specimen detected by the pcr reagent..
Kaohsiung Medical University


Single-cell nucleic acids for high-throughput studies


Described herein are cell-based analytic methods, including a method of incorporating nucleic acid sequences into reaction products from a cell population, wherein the nucleic acid sequences are incorporated into the reaction products of each cell individually or in small groups of cells individually. Also described herein is a matrix-type microfluidic device that permits at least two reagents to be delivered separately to each cell or group of cells, as well as primer combinations useful in the method and device..
Fluidigm Corporation


Hemoglobin a1c measurement method and measurement kit


This invention provides an amadoriase that acts on the β-chain of hemoglobin a1c (hba1c) and generates hydrogen peroxide, a method for measurement of hba1c using such amadoriase, and a reagent kit for measurement of hba1c using such amadoriase. The method for measurement of hba1c involves the use of an amadoriase that has specific activity of 0.1 u/mg or greater to αf6p and oxidizes the hba1c β-chain amino terminus so as to generate hydrogen peroxide, and the reagent kit for measurement of hba1c comprises such amadoriase.
Kikkoman Corporation


Methods for modifying a hydrophobic polymer surface and devices thereof


Aspects of the invention include methods for modifying a surface of a non-porous hydrophobic polymer substrate having a backbone containing electrophilic linkages. In practicing methods according to certain embodiments, a liquid composition having a nucleophilic reagent and a catalyst is contacted with the surface of the non-porous hydrophobic polymer substrate and maintained in contact with the surface of the polymer substrate in a manner sufficient to convert at least a portion of the surface from hydrophobic to hydrophilic while retaining the mechanical and optical properties of the polymer substrate.
The Board Of Trustees Of The Leland Stanford Junior University


Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery


Poly(amine-co-ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof.
Yale University


Readily isolated bispecific antibodies with native immunoglobulin format


A bispecific antibody format providing ease of isolation is provided, comprising immunoglobulin heavy chain variable domains that are differentially modified in the ch3 domain, wherein the differential modifications are non-immunogenic or substantially non-immunogenic with respect to the ch3 modifications, and at least one of the modifications results in a differential affinity for the bispecific antibody for an affinity reagent such as protein a, and the bispecific antibody is isolable from a disrupted cell, from medium, or from a mixture of antibodies based on its affinity for protein a.. .
Regeneron Pharmaceuticals, Inc.


Fenton reagent improved cyanation and usage thereof


This disclosure provides a facial green method for metal cyanides preparation, including the following steps: 1) supported metal nanoparticles and fenton's reagent are mixed with nitrile and then stirred to obtain suspension, wherein metal nanoparticles are selected from a nano metal, nano metal oxide and nano metal salt; 2) centrifuging the suspension to obtain a product and drying the product after stirring to obtain the metal cyanides. As prepared metal cyanides have broad application prospects in the fields of sensor, battery, medicine, electroplating and catalysis.
Zhejiang University


Ammonia synthesis for fertilizer production


A method for synthesizing ammonia for agricultural fertilizers employs water (h2o) as the source of hydrogen (h2) in ammonia (nh3) synthesis, and gathers carbon monoxide (co) as a limiting reagent for combining in a wgs (water-gas-shift) reaction for producing hydrogen. The wgs reaction employs co with the water to produce carbon dioxide (co2) and h2, consuming undesirable co from other industrial applications.

Ammonia synthesis for fertilizer production


A method for synthesizing ammonia for agricultural fertilizers employs water (h2o) as the source of hydrogen (h2) in ammonia (nh3) synthesis, and gathers carbon monoxide (co) as a limiting reagent for combining in a wgs (water-gas-shift) reaction for producing hydrogen. The wgs reaction employs co with the water to produce carbon dioxide (co2) and h2, consuming undesirable co from other industrial applications.

Apparatus for mixing based on oscillatory flow reactors provided with smooth periodic constrictions


The present application relates to an improved apparatus for mixing intensification in multiphase systems, which can be operating in continuous or batch mode. The apparatus is based on oscillatory flow mixing (ofm) and comprises a novel oscillatory flow reactor (ofr) provided with smooth periodic constrictions (spcs).
Universidade Do Minho


Method and fluid dispensation, preparation and dilution


A mixing vial is provided for an automated biological reaction apparatus typically used for staining tissue samples in immuno-histological and in-situ hybridisation reactions. The mixing vial allows reagents placed on the apparatus to be mixed together to form additional or blended reagents.
Leica Biosystems Melbourne Pty Ltd


Compact high volume analytical instrument architecture


An analytical instrument architecture provides high analytical test throughput in a compact footprint. A dilution section creates dilutions of a sample, a reaction processing section contains containers for assay reaction and measurement, and a reagent storage section supports reagent storage and supply.
Siemens Healthcare Diagnostics Inc.


Release reagent for vitamin d compounds


A reagent composition for releasing vitamin d compounds bound to vitamin d-binding protein and an in vitro method for the detection of a vitamin d compound in which the vitamin d compound is released from vitamin d-binding protein by the use of this reagent composition as well as the reagent mixture obtained in this manner. Also disclosed is the use of the reagent compositions to release vitamin d compounds as well as a kit for detecting a vitamin d compound..
Roche Diagnostics Operations, Inc.


Antibodies and methods for detecting and isolating the common conjugation site-specific epitopes/antigens


This invention discloses the “artificially cleaved epitope (ace)” methods, antibodies, reagents, immunoassays, immunoaffinity isolation, and kits for all antibody-based applications of designing, detecting, or isolating the common ace epitopes/antigens in a sample. The ace methods can detect or isolate epitopes that are either absent or poorly accessible naturally to antibodies, and thus must be specifically and artificially created (free terminals) and/or exposed in a sample for antibody-based applications.

Homogenous immunoassay with compensation for background signal


Homogeneous immunoassays that allow for compensation of background signals inherent in samples and reagents. The use of homogeneous immunoassays for the detection of the presence or amount of symmetrical dimethyl arginine (sdma) in biological samples.
Idexx Laboratories, Inc.


Detection instrument, and detection system


The present invention provides a detection instrument capable of easily detecting an intended detection object without any skilled technique. The detection instrument (1) of the present invention includes a detection portion (12), a detection reagent which develops a color by specifically reacting with a detection object in a sample is placed in the detection portion (12), positional information of the detection reagent in the detection portion (12) is information on the detection object, and color development of the detection reagent can be optically read.
Nec Solution Innovators, Ltd.


Gas chromatograph intermediate processing apparatus and gas chromatograph


To provide a gas chromatograph allowing a substance led out from a measurement target component to reach a reduction reaction part and capable of preventing occurrence of a quantification error while preventing corrosion and sensitivity deterioration of a metal pipeline due to measurement non-related components such as halogen, sulfur and the like. The gas chromatograph includes: an oxidation reaction part into which a sample gas passed through a column is introduced and which oxidizes the measurement target component and converts the resultant measurement target component to a prescribed intermediate component to be led out therefrom; and an intermediate gas flow path for deriving the intermediate component from the oxidation reaction part, and in this configuration, a reagent to be reacted with measurement non-related components is provided in the intermediate gas flow path, and the reagent contains a metal element to be reacted with only oxygen..
Horiba Stec, Co., Ltd.


Biomolecule measuring device


To a biomolecule measuring apparatus, a semiconductor sensor for detecting ions generated by a reaction between a biomolecular sample and a reagent is set. The semiconductor sensor has a plurality of cells which are arranged on a semiconductor substrate, and each of which detects ions, and a plurality of readout wires.
Hitachi High-technologies Corporation


Chemiluminescence measurement device and same


The device includes a vessel group, a nozzle head having a gas suctioning and discharging mechanism, one or more nozzles, which are in communication with the suctioning and discharging mechanism, and to a front end of which a dispensing tip is attachable, and a magnetic force means capable of causing a magnetic field inside the attached dispensing tip, a nozzle moving mechanism, a linkage part provided to the nozzle head, linkable to the reaction vessel and capable of forming a confined space shielded from external light, a linkage part moving mechanism capable of moving the linkage part, a photometer, a shutter, and a reagent injection flow channel capable of injecting a reagent for chemiluminescence.. .

Boiler system and power plant including the same


A boiler system is provided including: a boiler that burns fuel containing sulfur content, chlorine content, and water content to generate a combustion gas; a bagfilter that removes sulfur oxide; a denitration section that removes nitrogen oxide; a desulfurizing absorbent supply section that mixes a desulfurizing absorbent into the combustion gas on an upstream side of the bagfilter; and a reformer that mixes a denitrating reagent into the combustion gas on an upstream side of the denitration section, wherein the bagfilter performs dry desulfurization, and a temperature of the combustion gas passing through the bagfilter and flowing into the denitration section is higher than 200° c. And 350° c.
Mitsubishi Hitachi Power Systems, Ltd.






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