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Reagent patents



      

This page is updated frequently with new Reagent-related patent applications.




Date/App# patent app List of recent Reagent-related patents
07/21/16
20160209437 
 Automatic analyzer patent thumbnailnew patent Automatic analyzer
In the field of automatic analyzers, as items to be analyzed are increase, various reagents differing in such properties as liquid viscosity and contact angle are being used more frequently, and this trend is expected to continue. Also, reagents now take various forms (e.g., a concentrated reagent to be diluted by the water of an automatic analyzer), and so does dilution water.
Hitachi High-technologies Corporation


07/21/16
20160209434 
 Method of lipid assay and reagent for use therein patent thumbnailnew patent Method of lipid assay and reagent for use therein
A method of lipid assay characterized by assaying the lipids contained in a blood component in the presence of an organic silicon compound. The method can cause specific conditions for direct methods while satisfying requirements such as no influence on precision of assay, no burden on assay apparatus, and easy availability..
Sekisui Medical Co., Ltd.


07/21/16
20160209408 
 Device for detecting an analyte patent thumbnailnew patent Device for detecting an analyte
This invention relates to a device for detecting an analyte in a sample comprising: a radiation source adapted to generate a series of pulses of electromagnetic radiation; a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing energy generated by non-radiative decay into an electrical signal; a detector which is capable of detecting the electrical signal generated by the transducer; a first reagent proximal to the transducer, the first reagent having a binding site which is capable of binding a labelled reagent proportionally to the concentration of the analyte in the sample, which labelled reagent being capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; a second reagent proximal to the transducer, the second reagent having a lower affinity for the labelled reagent under the conditions of the assay than the first reagent; and a third reagent proximal to the transducer, the third reagent having a binding site which is capable of binding the labelled reagent, wherein the third reagent has an affinity for the labelled reagent which is less influenced than the first reagent by the concentration of the analyte or the complex or derivative of the analyte.. .
Vivacta Limited


07/21/16
20160209332 
 Nucleic acid detection method, and device and kit for use in same patent thumbnailnew patent Nucleic acid detection method, and device and kit for use in same
The present invention aims to solve problems in the analysis of amplified nucleic acids, i.e., cost, workability, and contamination and pollution of samples. In the present invention, a sample containing a nucleic acid and a reagent for detecting the nucleic acid are mixed in a closed system.
Kaneka Corporation


07/21/16
20160209302 
 Automated  preparing biological specimens for examination patent thumbnailnew patent Automated preparing biological specimens for examination
The systems and methods disclosed herein permit automated preparation of biological specimens for examination. The disclosed systems and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids.
Roche Diagnostics Hematology, Inc.


07/21/16
20160209301 
 Multiple slide processing apparatus patent thumbnailnew patent Multiple slide processing apparatus
A slide processing apparatus comprises a slide or processing station which may include a plurality of cuvettes, each cuvette configured to receive a slide. A reagent fluid supply is coupled to each cuvette to deliver and apply reagent for treatment of the slide.
Ggb Company


07/21/16
20160208659 
 Reactor system and solid fuel composite therefor patent thumbnailnew patent Reactor system and solid fuel composite therefor
A reactor system includes a fluidized-bed. A fuel and a sulfur absorbent material are eluted through the fluidized-bed.
Gas Technology Institute


07/21/16
20160208363 
 Processes for recovering tantalum and niobium with carbon tetrachloride patent thumbnailnew patent Processes for recovering tantalum and niobium with carbon tetrachloride
There is provided a method of treating solid material, wherein the solid material includes target metallic material and one or more other metallic elements, wherein the target metallic material consists of at least one of tantalum and niobium, the method comprising contacting the solid material with a gaseous reagent material within a reaction zone, wherein the gaseous reagent material includes carbon tetrachloride.. .
Cvmr Corporation


07/21/16
20160208316 
 Method for the in vitro detection of strains of legionella pneumophila resistant to antibiotics patent thumbnailnew patent Method for the in vitro detection of strains of legionella pneumophila resistant to antibiotics
Disclosed is a method for the in vitro detection of strains of legionella pneumophila, resistant to antibiotics, in particular to the fluoroquinolones. Also disclosed are nucleotide probes and a kit of reagents allowing the detection of legionella pneumophila bacterial strains that are resistant to antibiotics, in particular of the fluoroquinolone type..
Centre Hospitalier Universitaire De Grenoble


07/21/16
20160208315 
 Reaction container, nucleic acid analysis device, and nucleic acid analysis method patent thumbnailnew patent Reaction container, nucleic acid analysis device, and nucleic acid analysis method
A reaction container includes a base material, an analysis well in which a nucleic acid analysis reagent used for a nucleic acid analysis is positioned, the analysis well being arranged on the base material and configured to analyze a sample containing a nucleic acid, and a quantification well in which a quantification reagent configured to specifically detect the nucleic acid is positioned, the quantification well being arranged on the base material and configured to quantify an amount of the nucleic acid contained in the sample, in which the nucleic acid contained in the sample is distributed into the quantification well and the analysis well.. .
Toppan Printing Co., Ltd.


07/21/16
20160208311 
new patent

Method for measuring cholesterol in high-density lipoprotein, and reagent for use in said method


Wherein r1 represents a linear or branched alkyl group having 8 to 22 carbon atoms or a linear or branched alkenyl group having 8 to 22 carbon atoms, r2, r3 and r4 are the same as or different from each other and represent a linear or branched alkyl group having 1 to 6 carbon atoms or a linear or branched alkenyl group having 2 to 6 carbon atoms, and x− represents an anion, and a polyanion.. .

07/21/16
20160208240 
new patent

Ngs workflow


The present invention relates to improved semi-automated methods that permit the extraction of nucleic acids from samples, preparation of pcr and post-pcr preparation steps of dna-libraries for next-generation sequencings methods that can be conducted. The methods and additional aspects relating to such methods are less laborious, safe costs, reagents and are less prone to contamination than comparable methods that are not automated..
Vela Operations Pte.ltd.


07/21/16
20160208235 
new patent

Detection and removal of misfolded proteins/peptides


The invention concerns the field of detecting and quantifying misfolded proteins/peptides. In particular the detection and quantification of misfolded proteins/peptides in body fluids, on cell surfaces of humans and mammals, the detection of misfolded proteins/peptides in reagents to be tested for scientific research and/or diagnostic use and in pharmaceutical medication or their additives and it concerns as well the removal of misfolded proteins/peptides from reagents to be tested for scientific research and/or for diagnostic purposes and from pharmaceutical medication or their additives.
Oxprotect Gmbh


07/21/16
20160208233 
new patent

Evolved sortases and use thereof


Evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are provided herein, for example evolved sortases that bind recognitions motifs comprising a laxt or lpxs sequence. Also provided are methods (e.g., orthogonal transpeptidation and diagnostics methods) for using such sortases.
President And Fellows Of Harvard College


07/21/16
20160208227 
new patent

Compositions and methods for controlling microbial growth


Provided are modified microorganisms which are modified such that their growth can be controlled using exogenously provided compounds. The microorganisms can be modified by genetic alterations that include a promoter inducible by a first exogenously supplied compound.
The Johns Hopkins University


07/21/16
20160208175 
new patent

Packed-bed tubular reactor for heterogeneous exothermic or endothermic catalytic reactions


A reactor for fischer-tropsch reaction effected in a three-phase system essentially consisting of a gaseous reagent phase, a liquid reacted phase and a solid catalytic phase, wherein the solid catalytic phase is composed of packed bodies encaged in at least one open-cell foam structure with a high thermal conductivity.. .
Eni S.p.a


07/21/16
20160207943 
new patent

Apparatus and methods for the automated synthesis of small molecules


Provided are methods for purifying n-methyliminodiacetic acid (mida) boronates from solution. Also provided are methods for deprotection of boronic acids from their mida ligands.
The Board Of Trustees Of The University Of Illinois


07/21/16
20160207045 
new patent

Labels, containers, providing reagents


The invention relates to systems and methods for marketing and using products such as liquid materials, especially liquid reagents for use in microbiological and cellular biological laboratory settings include the use of unique color and simple numeric or alphanumeric identifiers to quickly and easily identify any product from a catalog list of products. Methods of marketing, advertising and producing such products are also disclosed.
Life Technologies Corporation


07/21/16
20160206777 
new patent

Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells


A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound.
University Of Maryland, College Park


07/21/16
20160206271 
new patent

Radiography controlling the radiography apparatus


A radiography apparatus and a method for controlling the radiography apparatus are provided. The radiography apparatus includes a radiographer configured to acquire a first radiation image of a subject before a contrast reagent is injected into the subject, and acquire a second radiation image of the subject after the contrast reagent is injected into the subject.
Samsung Electronics Co., Ltd.


07/14/16
20160202281 

An application automatic micro droplet array screening system with picoliter scale precision


This invention is related to high-throughput screening field, in particular to an application method for automatic micro droplet array screening system of picoliter scale precision. According to this invention, the fluid driving system and the capillary are fully filled with fluid of low thermal expansion coefficient as the carrier fluid to thoroughly empty air bubbles in the capillary; after that, immersing the sampling end of capillary into the oil phase that is mutually immiscible with aqueous sample to aspirate a section of oil phase into the capillary for isolation of aqueous sample and carrier fluid; once completed, immersing the sampling end of capillary into the sample/reagent storage tube to aspirate a certain volume of aqueous sample into the capillary; finally, moving the sampling end of capillary to the oil phase above microwells on microwell array chip, and pushing the sample solution in the capillary into microwells to form sample droplet.
Zhejiang University


07/14/16
20160202280 

Methods and systems for automated pipette tracking


Described are pipetting systems that automatically track the dispensing and extracting of reagents to and from arrays of well locations. The systems track the position of a pipette with respect to the well locations, and selectively illuminate those locations to indicate the progress of pipetting operations.
Actrace, Llc


07/14/16
20160202275 

Specimen containing unit, specimen measurement cassette, specimen measurement unit, and specimen measurement device


A specimen containing unit according to one embodiment of the present invention relates to a structure for dipping a specimen into a reagent so as to react with the reagent, and the specimen containment unit comprises: a body portion rotatable by external force; an extension portion formed to be extended from one surface of the body portion at a predetermined length along a longitudinal direction; and a specimen containment portion provided to an end portion of the extension portion and including a containment hole formed to be penetrated while maintaining at a predetermined angle in the longitudinal direction so as to contain a specimen by a capillary phenomenon.. .
Infopia Co., Ltd.


07/14/16
20160202246 

Blood analysis method, control device, and blood cell analyzer


The present disclosure provided a blood cell analyzer, a control device and a blood analysis method thereof. In the method, a first reagent is mixed with a sample to obtain a first testing sample, and then a second reagent is mixed with the first testing sample for a further reaction to get a second testing sample for basophil classification and/or hgb measurement.
Shenzhen Mindray Bio-medical Electronics Co., Ltd.


07/14/16
20160202221 

Material for detecting phenol derivatives and applications thereof


Monolithic nanoporous material, which is self-standing (i.e. Self-supported or cohesive), solid and transparent, essentially devoid of cracks, transparent to uv radiation, obtained by the sol-gel process, the material having a basic nature and including a reagent capable of generating a stained product by forming a bond with phenol, a basic compound or mixture of basic compounds and a compound or mixture of oxidant compounds, method for preparation and use in the detection and in the selective depollution of phenol or one of its derivatives..
Essilor International (compagnie Generale D'optique)


07/14/16
20160202220 

Liquid phase phenol analysis


A liquid reagent composition for detecting phenol or phenol derivatives includes a reagent capable of generating a stained product by forming a bond with phenol, an oxidant compound or mixture of oxidant compounds, a basic compound or mixture of basic compounds. The ratio of [stained reagent]:[oxidant compound] is 1:2 to 50:1, having a ph greater than 7.
Centre National De La Recherche Scientifique - Cnrs


07/14/16
20160202204 

Electrochemical-based analytical test strip with ultra-thin discontinuous metal layer


An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample includes an electrically insulating base layer, a first electrically conductive layer disposed on the electrically insulating base layer and including at least one electrode, an enzymatic reagent layer disposed on the at least one electrode, a patterned spacer layer and a top layer. The electrochemical-based analytical test strip also includes an ultra-thin discontinuous metal layer with a nominal thickness of less than 10 nanometers disposed between the first electrically conductive layer and the top layer.
Cilag Gmbh International


07/14/16
20160202189 

Method for detecting transparent exopolymer particles in a water sample


Method for detecting transparent exopolymer particles in a water sample. The method comprises step of obtaining a water sample and introducing a fluorochromatic reagent to the water sample.
Kemira Oyj


07/14/16
20160201148 

Diagnostic methods and compositions


Methods and compositions for the identification of genetic-related information are provided. At least portions of methods provided herein may be performed without thermocycling.
Theranos, Inc.


07/14/16
20160201144 

Red blood cell lysis solution


The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as rna from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant.
Gen-probe Incorporated


07/14/16
20160201126 

Efficient biomolecule recycling method and system


A technique is disclosed for recapturing and recycling biomolecule reagents. The technique may be applied in a range of settings, including biopolymer synthesis, sequencing, and so forth.
Illumina, Inc.


07/14/16
20160201116 

Sequences and their use for detection of salmonella enteritidis and/or salmonella typhimurium


This invention relates to a rapid, accurate method for detection and characterization of salmonella enteritidis and/or salmonella typhimurium based on the presence of nucleic acid sequences, in particular, to a pcr-based method for detection, and to oligonucleotide molecules and reagents and kits useful therefore. This method is preferably employed to detect s.
E. I. Du Pont De Nemours And Company


07/14/16
20160201065 

Methods and compositions for selecting sirna of improved functionality


Efficient sequence specific gene silencing is possible through the use of sirna technology. Be selecting particular sirnas by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.
Thermo Fisher Scientific Inc.


07/14/16
20160201058 

Methods and compositions for selecting sirna of improved functionality


Efficient sequence specific gene silencing is possible through the use of sirna technology. By selecting particular sirnas by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.
Thermo Fisher Scientific Inc.


07/14/16
20160200919 

Structured endothermic fire-retardant agents


A fire-retardant composition includes a first reagent and a second reagent; the first reagent is isolated from the second reagent; and the first reagent and the second reagent are configured to react with each other endothermically.. .
Empire Technology Development Llc


07/14/16
20160200753 

Ligated anionic-element reagent complexes (laercs) as novel reagents


A novel ligated reagent complex is provided. The ligated reagent includes at least one zero-valent atom, whether metal, metalloid, or non-metal, in complex with at least one hydride molecule and at least one nitrile compound.
The University Of Manitoba


07/14/16
20160200707 

Urazole compounds


The present invention relates to a compound of formula (i) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (i) wherein r1, r2, r3, r4, r5, r6, r7, l1 and q1 have the meaning defined in the claims and the description. The present invention also relates to a process for the preparation of the compound of formula (i).
Universiteit Gent


07/14/16
20160199916 

Synthesis of ferromagnetic manganese-bismuth nanoparticles using a manganese-based ligated anionic-element reagent complex (mn-laerc) and formation of bulk mnbi magnets therefrom


A method for synthesizing ferromagnetic manganese-bismuth (mnbi) nanoparticles, and the mnbi nanoparticles so synthesized, are provided. The method makes use of a novel reagent termed a manganese-based anionic element reagent complex (mn-laerc).
The University Of Manitoba


07/14/16
20160199854 

Separation of copper minerals from pyrite using air-metabisulfite treatment


The present invention relates to flotation of sulfidic copper-molybdenum- and gold-containing minerals. More specifically, the invention relates to sulfoxy reagent-assisted floatation for separating of sulfides of copper, molybdenum and gold from pyrite, marcasite, pyrrhotite, arsenopyrite, and other gangue minerals following aerating by an oxidizing gas and contacting by a sulfoxy reagent.
Barrick Gold Corporation


07/14/16
20160199836 

Centrifugal channel device


The centrifugal channel device includes a channel body, a collecting unit and a waste liquid tank. The channel body includes a first surface and a second surface relatively disposed.
Delta Electronics, Inc.


07/14/16
20160199538 

Collagen scaffold modified by covalent grafting of adhesion molecules, associated methods and use thereof for cardiovascular and thoracic cell therapy and contractile tissue engineering


Three-dimensional solid contractile collagen scaffolds having improved biological properties and electromechanical performance are provided. The scaffolds can be used for cell transplantation, including the fixation of biocompatible reagents and adhesion molecules which control cell adhesion, apoptosis, survival and/or differentiation simultaneously.

07/14/16
20160199407 

Halides in the treatment of pathogenic infection


The present invention relates to the use of halides and halide salts for the treatment of microbial infections, including those caused by bacteria, fungi and viruses. The present invention takes advantage of endogenous immune function and augments this system using a non-toxic and inexpensive reagent that can be delivered to mucosal surfaces, for example, orally, topically, opthalmically and via inhalation..
The University Of Iowa Research Foundation


07/07/16
20160195808 

Reagent for enhancing generation of chemical species


A reagent that enhances acid generation of a photoacid generator and composition containing such reagent is disclosed.. .
Toyo Gosei Co., Ltd.


07/07/16
20160195564 

Automated sampling and reaction system for high pressure liquid chromatography and other types of detection


Automated sampling and reaction systems and methods of using the same are provided. The automated sampling and reaction system has a microreactor in fluidic communication with an external sampling valve.
Waters Technologies Corporation


07/07/16
20160195563 

Automated analyzer


A panel holding base holding an operating panel disposed on a front-face side of a device upper part of an automated analyzer is inclined so as to rise from a lower end side on the front-face side toward an upper end side, and has a shape with increasingly narrower width from the lower end side toward the upper end side. As a result, increased operating panel operability and improved access to a sample disc or a reagent disc are simultaneously achieved..
Hitachi High-technologies Corporation


07/07/16
20160195562 

Automated analyzer


To provide an automated analyzer with a built-in, user-friendly printer that can avoid contamination of printed paper of the printer by having a housing front wall 102 provided in a recessed manner from a front end 101 of a housing upper portion that has disposed thereon a sample disc 110, a reagent disc 120, a reaction disc, a sample dispensing mechanism, and a reagent dispensing mechanism, and by having a printer 200 and a paper receptacle 210 disposed on the housing front wall. The front end portion of the housing upper portion that projects beyond the housing front wall serves as eaves, thereby preventing a sample or a reagent that may be spilled on the housing upper portion from staining the printer or printing paper..
Hitachi High-technologies Corporation


07/07/16
20160195561 

Analysis device and analysis method


An analysis device is provided with a first disk on which a sample container and disposable container can be disposed, a second disk on which a solid-phase extraction cartridge and disposable container can be disposed, a first probe capable of transferring a sample of the sample container disposed on the first disk or a solution of the disposable container disposed on the first disk to the solid-phase extraction cartridge or disposable container disposed on the second disk, and a second probe capable of transferring a reagent of a reagent container to the sample container or disposable container disposed on the first disk and the solid-phase extraction cartridge or disposable container disposed on the second disk. Sample preprocessing before solid-phase extraction processing takes place on the first disk..
Hitachi High-technologies Corporation


07/07/16
20160195560 

Specimen analyzing method and specimen analyzing apparatus


A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen..
Sysmex Corporation


07/07/16
20160195556 

25-oh vitamin d derivatives for determining vitamin d metabolites


The present invention relates to new vitamin d compounds which are bonded to a labelling group at the c3 stereocentre by means of a linker. The present invention further relates to a method for producing these vitamin d compounds and to the use of an intermediate for producing these compounds.
Orgentec Diagnostika Gmbh


07/07/16
20160195551 

Method for evaluating salivary adiponectin level and kit for measuring salivary adiponectin level


A method for evaluating a salivary adiponectin level, comprising evaluating the salivary adiponectin level by the level of multimeric adiponectin of 280 kda or more. A method for evaluating a salivary adiponectin level, wherein a saliva sample is fractionated into human multimeric adiponectin of 280 kda or more and human multimeric adiponectin of less than 280 kda.
Nipro Corporation


07/07/16
20160195544 

Method of diagnosing sepsis or sepsis risk


The present invention relates to methods of diagnosing sepsis or sepsis risk in a subject and methods of treating a patient for sepsis. The methods include detecting the presence of a subpopulation of neutrophils having an elevated integrin vla-3 (cd49c/cd29) expression level in the subject.
University Of Rochester


07/07/16
20160195530 

Method for analysis of nkt cell function


The present invention provides a superior method of functional analysis of nkt cells, which enables function analysis of low frequency nkt cells, is independent of the function of autologous apcs, and can avoid an influence of secondary factors and the like. More specifically, the present invention provides a method of functional analysis of human nkt cells including (a) cocultivating a mononuclear cell derived from human peripheral blood with a cd1d-expressing antigen presenting cell derived from a heterologous animal, and (b) evaluating the functionality of nkt cells with the number of nkt cells and/or a substance specific to functional nkt cells as an index; a reagent for analysis of human nkt cells containing a cd1d-expressing antigen presenting cell derived from a heterologous animal; a kit containing (a) a cd1d-expressing antigen presenting cell derived from a heterologous animal, and (b) at least one reagent selected from the group consisting of a reagent for selection of human mononuclear cell, a reagent for measurement of the number of human nkt cells and a reagent for measurement of a substance specific to human functional nkt cells; and the like..
Riken


07/07/16
20160195524 

Automated assay


Disclosed is a system and method for automating the performance of a conjugate or sandwich assay, and a cassette for use with the system. The cassette comprises a fluid conduit and one or more chambers in the fluid conduit, from which a measurement may be acquired from a sample using a cassette reader device.
University Of Strathclyde


07/07/16
20160195492 

Droplet operations platform


The invention relates to a droplet actuator device and methods for integrated sample preparation and analysis of a biological sample. A droplet actuator device is provided for conducting droplet operations.
Advanced Liquid Logic, Inc.


07/07/16
20160195490 

Biosensor


A biosensor comprising an insulative substrate (1) and an electrode system arranged on the insulative substrate (1). The electrode system comprises thereon a reagent capable of reacting with a test sample.
Leadway (hk) Limited


07/07/16
20160194719 

A biomarker of breast cancer


The invention provides methods of and diagnostic kits for the detection of breast cancer or to assist in assessing the prognosis, cancer comprising a reagent capable of identifying a circulating mirna, the mirna being the mir-138 biomarker. The invention also provides methods of identifying a therapeutic agent capable of preventing or treating cancers, including breast cancer, comprising testing the ability of the potential therapeutic agent to reduce the expression of mir-138..
National University Of Ireland, Galway


07/07/16
20160194646 

Methods and compositions for selecting sirna of improved functionality


Efficient sequence specific gene silencing is possible through the use of sirna technology. Be selecting particular sirnas by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.
Thermo Fisher Scientific Inc.


07/07/16
20160194385 

An antibody therapy for amyloid beta disease


The present disclosure relates generally to a protocol to treat or prevent diseases or conditions associated with pathological forms of amyloid beta (aβ), including alzheimer's disease. Enabled herein is a reagent for use in the treatment and prophylaxis of aβ-associated pathological conditions..
St. Vincent's Institute Of Medical Research


07/07/16
20160194300 

Reagent for enhancing generation of chemical species


A reagent that enhances acid generation of a photoacid generator and composition containing such reagent is disclosed.. .
Toyo Gosei Co., Ltd.


07/07/16
20160193603 

Sample-to-answer microfluidic cartridge


A microfluidic cartridge and methods for performing a diagnostic, molecular or biochemical assay thereon, where all dried and/or liquid reagents necessary for the assay are contained in the cartridge and the assay requires only the addition of sample. Pneumohydraulic features, chamber and diaphragm technologies are introduced for overcoming the problems of bubble interference and reagent washout during operation of a microfluidic cartridge.
Micronics, Inc.


07/07/16
20160193582 

Parallel organic synthesis on patterned paper using a solvent-repelling material


The present application is directed to a porous support for parallel organic synthesis comprising: a solvophilic area for spotting an organic solvent comprising a reagent for synthesizing an organic compound, and a solvophobic area that repels the organic solvent. Methods of synthesizing the support and compounds thereon are also provided..
The Governors Of The University Of Alberta


07/07/16
20160193242 

Methods and compositions for selecting sirna of improved functionality


Efficient sequence specific gene silencing is possible through the use of sirna technology. Be selecting particular sirnas by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.
Thermo Fisher Scientific Inc.


07/07/16
20160192901 

Warming gel system and method


A method of applying ultrasound gel including the steps of removing a barrier separating a reagent and a lubricating gel. The reagent and the lubricating gel are separated within a single packaging.
Thermal-gel, Llc


06/30/16
20160187773 

Reagent for enhancing generation of chemical species


A reagent that enhances acid generation of a photoacid generator and composition containing such reagent is disclosed.. .

06/30/16
20160187363 

Reactor, test apparatus, and test method


Disclosed herein are a reactor, a test apparatus, and a test method, which measure, when a material included in a sample acts as an interfering material with respect to estimating a concentration of a target material, a concentration of the interfering material, and correct an estimated concentration of the target material based on the concentration of the interfering material, thereby improving the reliability and accuracy of the concentration of the target material. The reactor includes: a target material detecting chamber in which a first reagent that includes a first material that is activated by a target material is contained; a first material detecting chamber in which a second reagent that includes the target material is contained; an inlet hole into which a sample is injected; and a channel configured to connect the inlet hole, the target material detecting chamber, and the first material detecting chamber to each other..

06/30/16
20160187360 

Reagent preparation support equipment, program for implementation thereof, and computer-readable recording medium on which this program is recorded


Disclosed herein is a reagent preparation supporting device including: reagent kit information storing means that stores amounts of reagents required for one analysis and a composition of a reaction liquid to be prepared; an input unit that inputs the number of samples to be analyzed; reagent amount calculating means that calls up, from the reagent kit information storing means, the data regarding the reagent kit to calculate required amounts of the reagents included in the reagent kit and a composition of the reaction liquid according to the number of samples inputted through the input unit; and a display unit that displays, as a reagent preparation table, the required amounts of the reagents included in the reagent kit and the composition of the reaction liquid to be prepared based on results calculated by the reagent amount calculating means.. .

06/30/16
20160187337 

Assay for jc virus antibodies


The disclosure relates to methods and reagents for analyzing samples for the presence of jc virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles hpvlps) under conditions suitable for binding of a jcv antibody in the sample to an hpvlp, and detecting the level of jcv antibody binding in the sample to hpvlp in one embodiment, determining the level of anti-jcv antibodies in the subject sample provides a method of identifying pml risk in a subject..

06/30/16
20160187335 

Method and device for detecting sample


According to one embodiment, a method for detecting a sample includes preparing a device for detecting a sample, the device including a measurement cassette, a first chamber formed by partitioning the cassette with a partition wall, a through-hole provided in the partition wall, a first electrode provided in the cassette, and a second electrode provided in the cassette, introducing a reagent and a sample containing a measuring object substance into the first chamber, introducing a conductive liquid into the second chamber, supplying current to the through-hole, allowing the measuring object substance whose surface is bound to and is covered by the tag particles via the capture substance in the first chamber to pass through the through-hole, and detecting presence of the measuring object substance.. .

06/30/16
20160187291 

Glucose test strip with interference correction


A test strip comprising a base layer, the base layer having an optional hematocrit anode configured to determine a value corresponding to a hematocrit level of a fluid sample, wherein the hematocrit anode may be coated with a reagent, an interference anode configured to determine a value corresponding to a measurement of an interference caused by one or more oxidizable substances in the sample fluid, wherein the interference anode electrode includes an interference reagent on its surface, a glucose anode, the glucose anode being configured to determine a glucose level in the fluid sample, wherein the glucose anode is covered with a reagent comprising a mediator and an analyte specific enzyme, and one or more cathodes in a cooperative relation with the hematocrit anode, the interference anode, and the glucose anode to measure the hematocrit level, the interference and the glucose level.. .

06/30/16
20160187283 

Electrochemical-based analytical test strip with a soluble electrochemically-active coating opposite a bare electrode


Electrochemical-based analytical test strip with a soluble electrochemically-active coating opposite a bare electrode an electrochemical-based analytical test strip (ebats) for the determination of an analyte in a bodily fluid sample includes an electrically insulating base layer, a patterned electrically conductive layer disposed on the electrically insulating base layer and including a plurality of electrodes, and an enzymatic reagent layer disposed on a portion of the patterned conductor layer and defining a bare electrode(s) and a plurality of enzymatic reagent covered electrodes from the plurality of electrodes. The ebats also includes a patterned spacer layer, a top layer having an underside surface (uss), and a soluble electrochemically-active coating (seac) disposed on the uss of the top layer.

06/30/16
20160186632 

Injection device for reagent


An injection device for administering a reagent into an exhaust passage of an internal combustion engine, the injection device having an axis along its length and comprising an outwardly opening valve member having a seating surface which is engageable with a valve seating region. A seating member provided with an internal bore which defines the valve seating region, wherein the internal bore further defines a flow re-directing region downstream of the valve seating region.

06/30/16
20160186548 

Enhanced subterranean resource recovery


Methods of resource recovery include reagents placed in a subterranean formation. The reagents generate heat, hydrogen gas and alkalinity which changes fluid flow characteristics.

06/30/16
20160186331 

Method for forming a coating on a solid substrate, and article thus obtained


A method for forming a surface coating on at least a part of a solid substrate, comprising a step of cold spraying a flow comprising at least one carrier gas, and particles suitable for deposition on the said substrate, said flow having a speed of more than 350 m/s; the particles are obtained from inorganic materials and have dimensions smaller than 200 μm. One or more mixtures of reaction precursor reagents are present in at least some of the particles.

06/30/16
20160186291 

Continuous ore process and apparatus using plasma


A method of processing ore using a plasma arc reactor includes the steps of first determining the content of the ore, modeling the plasma arc reaction for different stoichiometric ratios of ore to candidate reagents, selecting one or more of candidate reagents pre-mixing the selected reagents with the ore at corresponding stoichiometric ratios, and continuously feeding the pre-mixed ore into a plasma arc reactor, and controlling the plasma arc reaction according to the previously modeled conditions.. .

06/30/16
20160186268 

Gene defects and mutant alk kinase in human solid tumors


Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of anaplastic lymphoma kinase (alk) kinase with part of a secondary protein have been identified herein in human solid tumors, e.g. Non-small cell lung carcinoma (nsclc).

06/30/16
20160186261 

Prevotella copri and enhanced susceptibility to arthritis


Methods, reagents and compositions thereof for predicting risk for nora onset in susceptible individuals, diagnosing nora onset, and/or evaluating efficacy of a therapeutic regimen for treating ra are described herein. Determining the amount of at least one of seq id nos: 1-19 and/or at least one of a ko presented in either of tables s4 or s5 serves as a biomarker for the above indications..

06/30/16
20160186252 

Ph measurement for sequencing of dna


The present method involves sequencing by synthesis in which a template strand having an attached primer is immobilized in a small volume reaction mixture. In one embodiment, the reaction mixture is in contact with a sensitive heat sensor, which detects the heat of reaction from incorporation of a complementary base (dntp) in the presence of appropriate reagents (dna polymerase, and polymerase reaction buffer).

06/30/16
20160186249 

Tagged oligonucleotides and their use in nucleic acid amplification methods


The present invention provides nucleic acid amplification systems and methods that desirably reduce or eliminate false positive amplification signals resulting from contaminating biological material, e.g., nucleic acid, that may be present in one or more reagents used in an amplification reaction and/or that may be present in the environment in which an amplification reaction is performed. The invention offers the further advantage of requiring less stringent purification and/or sterility efforts than conventionally needed in order to ensure that enzymes and other reagents used in amplification reactions, and the environment in which an amplification reaction is performed, are free of bacterial or other nucleic acid contamination that may yield false positive results..

06/30/16
20160186244 

Real time cleavage assay


A cleavage-based real-time pcr assay method is provided. In general terms, the assay method includes subjecting a reaction mixture comprising a) pcr reagents for amplifying a nucleic acid target, and b) flap cleavage reagents for performing a flap cleavage assay on the amplified nucleic acid target to two sets of thermocycling conditions.

06/30/16
20160186240 

Devices and methods for molecular diagnostic testing


A hand-held molecular diagnostic test device includes a housing, an amplification (or pcr) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume.

06/30/16
20160186238 

Reactivity-dependent and interaction-dependent pcr


Methods, reagents, compositions, and kits for reactivity-dependent polymerase chain reaction (rd-pcr) and interaction-dependent polymerase chain reaction (id-pcr) are provided herein. Rd-pcr is a technique useful for determining whether a reactive moiety can form a covalent bond to a target reactive moiety, for example, in screening a library of candidate reactive moieties for reactivity with a target reactive moiety, and in identifying an enzyme substrate, for example, in protease substrate profiling.

06/30/16
20160186087 

Reduced engine deposits from dispersant treated with cobalt


The invention provides a lubricating composition containing an oil of lubricating viscosity and a dispersant treated with cobalt reagent. The invention further relates to methods of lubricating an internal combustion engine by supplying the described lubricating composition to the internal combustion engine.

06/30/16
20160185812 

Process for synthesizing highly optically active 1,3-disubstituted allenes


The present invention relates to a process for efficiently synthesizing highly optically active 1,3-disubstituted allenes, i.e., a one-step process for preparing highly optically active 1,3-disubstituted allenes by using a functionalized terminal alkyne, an aldehyde and a chiral α,α-diphenyl prolinol as reactants under the catalysis of a divalent copper salt. The operation of the process is simple, and the raw materials and reagents are readily available.

06/30/16
20160185751 

Method for preparing benzamide derivative, novel intermediate used in preparation of benzamide, and preparing novel intermediate


The present invention relates to a method for preparing n-[[1-{3-(1,2,3-triazol-1-yl)propyl}piperidin-4-yl]methyl]-4-amino-5-chloro-2-methoxybenzamide, which is a novel benzamide derivative as a 5-ht4 receptor agonist, or a pharmaceutically acceptable salt thereof; to a novel intermediate capable of being used in the preparation of the compounds; and to a method for preparing the same. The preparation methods of the present invention can be useful for mass production since a low-priced reagent and intermediate are used and the number of reaction processes is decreased, thereby saving preparation costs and improving the yield..

06/30/16
20160185708 

1-(2-acyloxyethyl)cyclopropyl sulfonate compound, 3-halomethyl-3-butenyl carboxylate compound, and producing 4-alkyl-3-methylenebutyl carboxylate


Provided is a simple, selective and efficient method for producing 4-alkyl-3-methylenebutyl carboxylates such as 7-methyl-3-methylene-7-octenyl propionate. More specifically, provided is, for example, a method for producing a 4-alkyl-3-methylenebutyl carboxylate compound, comprising an acyloxylation step of subjecting a 1-(2-haloethyl)cyclopropyl sulfonate compound (1) to acyloxylation to obtain a 1-(2-acyloxyethyl)cyclopropyl sulfonate compound (2), a halogenation step of subjecting the compound (2) to halogenation involving cyclopropyl-allyl rearrangement to obtain a 3-halomethyl-3-butenyl carboxylate compound (3), and a coupling step of subjecting the compound (3) to a coupling reaction with an organometallic reagent (4) to obtain the 4-alkyl-3-methylenebutyl carboxylate compound (5)..

06/30/16
20160185707 

3-acyloxymethyl-3-butenyl carboxylate compound and producing 4-alkyl-3-methylenebutyl carboxylate


Provided is a simple, selective and efficient method for producing 4-alkyl-3-methylenebutyl carboxylates such as 7-methyl-3-methylene-7-octenyl propionate. More specifically provided is a method for producing a 4-alkyl-3-methylenebutyl carboxylate compound, the method comprising a diacyloxylation step of subjecting a 4-halo-2-halomethyl-1-butene compound (6) to diacyloxylation to obtain a 3-acyloxymethyl-3-butenyl carboxylate compound (3), and a coupling step of subjecting the 3-acyloxymethyl-3-butenyl carboxylate compound (3) to a coupling reaction with an organometallic reagent (4) to obtain the 4-alkyl-3-methylenebutyl carboxylate compound (5)..

06/30/16
20160185705 

Hydrobromination method


A process for synthesizing a product of formula br—(ch2)n—r by hydrobromination, by reacting: a reagent of formula (i) r1-ch═ch—r2 in which r1 and r2, identical or different, are chosen from h or an alkyl radical comprising 1 to 30 carbon atoms, which is saturated or unsaturated, linear or branched, functionalized or non-functionalized, with a molar excess of hbr relative to the reagent of formula (i), in the presence of a radical initiator, and optionally in the presence of at least one solvent, said process including a step a of mixing at least reagent i and the hbr, each of the latter arriving in the form of a flow of liquid into a mixing device da.. .

06/30/16
20160185691 

One-component reagent for the fluoroalkylation reaction


A composition, consisting essentially of copper, a fluoroalkyl group, and a ligand comprising at least one group-v donor. The molar ratio of copper to the fluoroalkyl group is approximately 1..

06/30/16
20160184826 

Reagent supplying device


Provided are a reagent supply method and device capable of using up a reagent in a container without a remnant to the extent possible, and supplying the reagent to an analysis device without mixing air bubbles even when the remaining amount of the reagent is extremely small. The reagent supply device includes: at least one reagent container including: a container body for storing a liquid reagent; and a reagent supply port arranged on the container body; and a support member for supporting the at least one reagent container so that the reagent supply port is positioned on a lower side of the container body.

06/30/16
20160184789 

Microchemical chip and reaction device


A simple and compact microchemical chip has a fine flow path formed therein through which a specimen is made to flow; is break resistance; makes it possible to flow the fluid sample to the flow path; makes it possible to analyze a useful substance and cause it to react; and can be produced with a high yield. A microchemical chip includes: a rubber sheet having a penetrated flow path which chemically reacts a pressurized fluid sample selected from a specimen and a reagent by flowing thereinto; substrate sheets which sandwich the rubber sheet and bond to both faces thereof by direct bond or by chemical bond through a silane-coupling agent and are selected from metal, ceramics, glass, and resin; and a hole for injecting the fluid sample into the flow path and a hole for draining the fluid sample flowed therefrom which are opened into the substrate sheet..

06/30/16
20160184443 

Novel plga-modified polyethylenimine self-assembly nanotechnology for nucleic acid and drug delivery


Embodiments of the invention concern copolymers and nanoparticles for use as delivery agents for one or more agents for therapy for a medical condition of humans and animals. Some of embodiments of the invention provide new reagents for biomedical research in cell culture, animal models and plants, for example.

06/30/16
20160184363 

Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids


The present invention relates to the fields of medicine, cell biology, molecular biology and genetics. In particular, the present invention provides methods to isolate and purify microvesicles from cell culture supernatants and biological fluids.

06/23/16
20160178651 

Blood sample determination method and blood sample analyzer


Disclosed is a blood sample determination method including: emitting light to a measurement specimen prepared by mixing a clotting time measuring reagent and a blood sample suspected to be derived from a subject having lupus anticoagulant or a coagulation factor inhibitor, to obtain optical information about an amount of light from the measurement specimen; obtaining at least one parameter regarding derivative of clot waveform, based on the obtained optical information; and determining, based on a value of the obtained parameter, whether the blood sample is suspected to be a sample derived from a subject having lupus anticoagulant or is suspected to be a sample derived from a subject having a coagulation factor inhibitor.. .

06/23/16
20160178639 

Sampling devices and methods of use


Sample-collecting devices, articles and methods of use are disclosed. Premoistened sample-collecting devices comprise 1,2-propanediol as a humectant, which promotes the retention of a liquid solution on the sample-collecting device during storage.

06/23/16
20160178624 

Device and method to perform multiplex assays and target enrichment


A device termed the mobilearray™ device and methods, which form the mobilearray™ system, are disclosed for performing multiplex assays, target enrichment or purification. The device and methods disclosed enable the performing of multiplex assays, target enrichment or purification in a simplified manner.

06/23/16
20160178623 

Assay device having multiple reagent cells


An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone. The reagent zone includes at least two reagent cells containing a reagent material and arranged in the reagent zone such that each reagent cell experiences substantially the same flow conditions of sample from the sample zone.

06/23/16
20160178603 

Composite material with failure detection properties


A multiple layer composite material having fluid breach detection features provides indication of a failure in a fluid barrier. The indication of breach of fluid is provided before failure of a final layer of the composite material.

06/23/16
20160178594 

Analyzer sensing a chemical characteristic of a fluid sample


An analyzer system for sensing a chemical characteristic of a fluid sample according to one embodiment includes a sample inlet configured to receive the sample via the sample inlet, a reagent inlet configured to receive a reagent via the reagent inlet, a reaction zone in fluid communication with the sample inlet and the reagent inlet and being configured to receive the sample from the sample inlet and the reagent from the reagent inlet for mixing the sample with the reagent; and a sensor zone in fluid communication with the reaction zone, wherein the sensor zone comprises a sensor configured to sense the chemical characteristic of the mixed sample and reagent, and further wherein the sensor zone is configured to allow automatic drainage of the mixed sample and reagent away from the sensor after the sensor has sensed the chemical characteristic of the mixed sample and reagent.. .

06/23/16
20160178592 

Apparatus for measuring concentrations of dissolved constituents


Provided is a device for measuring the concentration of a dissolved component, whereby the concentration of a plurality of types of dissolved components in water can be measured easily and with good precision. A device for measuring the concentration of a dissolved component has: a cell assembly 3 in which a plurality of cells 1 are connected by a joint member 2 and integrated, and a measurement reagent is accommodated in each of the cells 1; and a measuring main body 5 having a measurement unit (light-emitting element 8 and light-receiving element 9) for measuring transmittance and absorbance, the cells 1 of the cell assembly 3 being inserted into the measurement unit.

06/23/16
20160178571 

Compositions, kits, and devices for generating and accurately measuring different oxygen levels in calibration and/or quality control reagents and methods of production and use thereof


Compositions, kits, and devices that include calibration and/or quality control reagent(s) for monitoring the performance of blood gas, electrolyte, and/or metabolite instrumentation are disclosed. Different oxygen levels in the calibration and/or quality control reagent(s) can be generated using an oxygen scavenger.

06/23/16
20160178526 

Optical sensor device for repetitive assays in biological fluids


Annular shaped sensor devices are disclosed that comprise an axial array of wedge-shaped optical sensors having tips oriented inward, with analyte-reactive reagents resident on a portion of the tip surfaces. These annular optical sensor devices are cut out from sheets or continuous sheeting of flat optically transparent polymers, and are preferably coated with a cladding material on major surfaces, other than the tips, so as to function as optical light guides.





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