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Reagent patents



      
           
This page is updated frequently with new Reagent-related patent applications. Subscribe to the Reagent RSS feed to automatically get the update: related Reagent RSS feeds. RSS updates for this page: Reagent RSS RSS


Platelet measurement reagent, platelet measurement reagent kit, and platelet measurement method

Platelet measurement reagent, platelet measurement reagent kit, and platelet measurement method

Platelet measurement reagent, platelet measurement reagent kit, and platelet measurement method

Polymer backbone element tags

Date/App# patent app List of recent Reagent-related patents
07/02/15
20150187517
 Structural composite battery with fluidic port for electrolyte patent thumbnailnew patent Structural composite battery with fluidic port for electrolyte
According to the invention there is provided a fluidic port (8-9) for a refillable structural composite electrical energy storage device(1), and a method of producing same. The device may be a battery or supercapacitor with first and second electrodes (2,3) which are separated by a separator structure (6), wherein the device contains an electrolyte (4) which may further contain active electrochemical reagents.
07/02/15
20150185242
 Automatic analyzer patent thumbnailnew patent Automatic analyzer
There is provided an automatic analyzer including: a sample pipetting mechanism 7, reagent pipetting mechanisms 12a and 12b, mixing mechanisms 33a and 33b, a scattered light photometer 40, and an absorption photometer 41 all located on a transfer path of reaction cells 2 arranged circumferentially on a disk-shaped reaction disk 1, the reaction cells 2 being transferred in the circumferential direction by rotation of the reaction disk 1. Scattered light intensity and absorbance are controlled to be measured by causing the reaction cells 2 to move past a scattered light detection position and a transmitted light detection position in the same process of movement, the two positions being established beforehand on the transfer path.
07/02/15
20150185236
 Blood coagulation time prolonging agent patent thumbnailnew patent Blood coagulation time prolonging agent
Provided is a reagent, which prolongs a blood coagulation time sufficiently and enhances an optical change, thereby enabling a correct and high-sensitive blood coagulability test. The present invention provides a blood coagulation time prolonging agent, including, as an active ingredient, a guanidine compound represented by the following formula (1) or an acid addition salt thereof (in the formula, r1 represents a hydrogen atom, an amino group, or an alkyl group which may have a substituent)..
07/02/15
20150185230
 Identification of patients with abnormal fractional shortening patent thumbnailnew patent Identification of patients with abnormal fractional shortening
The present invention relates to a method for assessing whether a subject shall be subjected to an imaging based diagnostic assessment. The method is based on the determination of the amount(s) of a cardiac troponin and/or fibroblast growth factor 23 (fgf-23) in a sample from the subject, and on the comparison of the, thus, determined amount(s) with a reference amount (reference amounts).
07/02/15
20150185210
 Platelet measurement reagent, platelet measurement reagent kit, and platelet measurement method patent thumbnailnew patent Platelet measurement reagent, platelet measurement reagent kit, and platelet measurement method
A reagent for measuring platelets comprising nile blue hydrogensulfate, or nile blue and an acid, a reagent kit for measuring platelets comprising the reagent for measuring platelets, and a method for measuring platelets using the reagent or reagent kit.. .
07/02/15
20150185118
 Microfluidic devices and methods patent thumbnailnew patent Microfluidic devices and methods
Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices.
07/02/15
20150184158
 Translocation and mutant ros kinase in human non-small cell lung carcinoma patent thumbnailnew patent Translocation and mutant ros kinase in human non-small cell lung carcinoma
In accordance with the invention, a novel gene translocation, (4p15, 6q22), in human non-small cell lung carcinoma (nsclc) that results in a fusion proteins combining part of sodium-dependent phosphate transporter isoform napi-3b protein (slc34a2) with proto-oncogene tyrosine protein kinase ros precursor (ros) kinase has now been identified. The slc34a2-ros fusion protein is anticipated to drive the proliferation and survival of a subgroup of nsclc tumors.
07/02/15
20150183895
 Polymer backbone element tags patent thumbnailnew patent Polymer backbone element tags
Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including icp-ms. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user.
07/02/15
20150183738
 3-n-butyl-1-isoindolinone and use thereof for preventing or treating cerebral infarction patent thumbnailnew patent 3-n-butyl-1-isoindolinone and use thereof for preventing or treating cerebral infarction
3-n-butyl-1-isoindolinone and use thereof for preventing or treating cerebral infarction. The compound is prepared by: 1) employing phthalimide as a starting reactant, contacting a nucleophilic grignard reagent with the original reactant to add an alkyl group to a carbonyl carbon of an amide bond of the original reactant, thus yielding an intermediate; and 2) removing an oxygen atom connected to a third carbon atom of the intermediate in the presence of boron trifluoride diethyl etherate as a catalyst and triethylsilane as a reductant..
07/02/15
20150183145
 Plastic-metal composite material and manufacturing method thereof patent thumbnailnew patent Plastic-metal composite material and manufacturing method thereof
Disclosed are a plastic-metal composite material and a manufacturing method thereof. The method including: s1.
07/02/15
20150183009
new patent

Composition for treating an excavation activity


A composition for treating an excavation activity includes a reagent suspended in foam to form a reagent-foam mixture. The reagent is selected to react with at least one of sulfides or bacteria in waste rock or tailings materials to reduce acid rock drainage.
07/02/15
20150182966
new patent

Field deployable small format fast first result microfluidic system


A field-deployable small format microfluidic system includes simplified, low-cost system control elements, optics, fluid control, and thermal control. An embodiment of a microfluidic chip includes a first plate having reagent wells and pneumatic ports formed therein, a second plate with reaction wells and microfluidic channels connecting each reaction well with one reagent well and one pneumatic port formed therein, and a printed circuit board with heater elements, a temperature sensor, and thermal vias providing thermal transfer through the pcb.
07/02/15
20150182963
new patent

Systems and methods for reagent storage


A microfluidic device for storing a reagent includes a single unit includes a first portion having a reagent storage chamber configured to hold a reagent. The device also includes a second portion having a reaction chamber configured to support the reagent during a reaction process to form a product.
07/02/15
20150182910
new patent

Apparatus and evaporating waste water and reducing acid gas emissions


An apparatus for evaporating waste water and reducing gas emissions includes an evaporator device (7, 31) configured to receiving a portion of flue gas emitted from a boiler unit (1) and waste water to directly contact the flue gas with the waste water to cool and humidify the flue gas and to dry solid particulates within the waste water. In some embodiments, the waste water may be a component of a mixture formed by a mixer device (25) prior to being contacted with the flue gas to humidify and cool the flue gas and dry solids within the waste water.
07/02/15
20150182421
new patent

Specimen collection apparatus


A specimen collection apparatus is provided. The specimen collection apparatus may include a container, a funnel for removable insertion in an opening of the container, a funnel cover; a removable seal, and a dispensing apparatus sealed within the funnel cover in a reagent-specific atmosphere.
07/02/15
20150182156
new patent

Quick test device and method


Test device (1) for testing a human or animal sample, such as blood or blood components, comprising a first part (2) and a second part (3), comprising co-operating first and second coupling elements (4, 5) for coupling the first part with the second part, and a sample absorbing and/or adsorbing element (17), wherein the first part comprises a fluid reservoir (20), and wherein the second part comprises at least one receptacle, wherein the fluid reservoir is reducible in volume for forcing a liquid contained therein through and/or along the adsorbing and/or absorbing element, forcing the sample such as blood or components thereof from the adsorbing and/or absorbing element into the receptacle, preferably into contact with at least one reagent (16) in the second part when the first and second part are connected or brought into connection with each other by at least the first and second coupling elements.. .
06/25/15
20150177258

Sh2 domain variants


The present invention relates to variant sh2 domains for binding a phosphotyrosine (ptyr)-containing peptide. The variant sh2 domains of the present invention include a parent sh2 domain having at least one amino acid substitution in a pre-defined region of 15 amino acid positions of the parent sr2 domain, wherein said at least one amino acid substitution increases the affinity of the variant sh2 domain for the ptyr-containing peptide relative to the parent sh2 domain.
The University Of Western Ontario
06/25/15
20150177244

Parallel analysis of serum epcam and mmp7 to discriminate sepsis, necrotizing enterocolitis and normal control patients


Methods and compositions are provided for making a necrotizing enterocolitis (nec) or sepsis assessment of an individual. Aspects of the methods include detecting a biomarker or panel of biomarkers selected from mmp7, epcam, and crp.
The Board Of Trustees Of The Leland Stanford Junior University
06/25/15
20150177236

Combined chemiluminescence and elisa automated sample reader


The automated reader operates within an enclosure also containing a sample rack and reagent rack, as well as a microtiter plate with multiple wells therein. The machine automatically loads sample and reagent into a well of the microtiter plate according to a testing protocol.
Gold Standard Diagnostics
06/25/15
20150177232

Clinical specimen detector


A clinical specimen detector includes a clip having a clamping end and a pressing end; and wherein a pair of compressing slices are disposed on the clamping end, and a channel is disposed in the lower end of at least one of the pair of compressing slices. A detecting reagent test chip is attached to the outer surface of the compressing slice.
National Tsing Hua University
06/25/15
20150177183

Reversible detection of ions with permselective membranes


The present invention relates to an electrochemical method using a permselective membrane for detection of ions in a sample. The permselective electrode includes a lipophilic reagent such as a neutral ionophore or an ion exchanger and a lipophilic ion, the lipophilic reagent being in molar excess relative to the lipophilic ion.
Universite De Geneve
06/25/15
20150177178

Matrix stability compositions, test elements, test systems and methods of use thereof


reagent matrices and methods are disclosed for improving the stability of test elements with respect to degradation by humidity in the air. The reagent matrices and methods are based upon using an effective amount of a deliquescent material to decrease the sorption of water from the air by other components of a reagent matrix.
Roche Diabetes Care, Inc.
06/25/15
20150177147

Biological fluid analysis system and method


A biological fluid analysis system and method for measuring optical characteristics of a sample of biological fluid using a commercially available portable computing device having a camera, such as a smart phone. The system includes a scope, a case that attaches to the portable computing device, and a software application that runs on the portable computing device.
Dairy Quality Inc.
06/25/15
20150176895

Method of drying transport/storage containers for radioactive waste


A method of drying a transport/storage container for radioactive waste where the container holds water at least some of which is chemically bound with a boron compound. The method has the steps of first adding to the water in the container a reagent that frees the boron compound from the chemically bound water, and then removing by vacuum drying the water in the container including the water that has been freed of the boron compound..
06/25/15
20150176463

Pressure swirl flow injector with reduced flow variability and return flow


A reagent injector with a cartridge design has a body with a reagent inlet, outlet, and a swirl chamber, which has an exit orifice that may be covered and uncovered by a solid, movable pintle. Reagent flows through the injector when the exit orifice is covered and uncovered to cool the injector.
Tenneco Automotive Operating Company, Inc.
06/25/15
20150176461

Electromagnetically controlled injector having flux bridge and flux break


An injector for injecting a reagent includes an axially translatable valve member positioned within a housing. An electromagnet is positioned within the housing and includes a cylindrically-shaped coil of wire.
Tenneco Automotive Operating Company Inc.
06/25/15
20150176081

Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments


Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (egfr) targeting treatment. The detection of these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug..
Dana-farber Cancer Institute, Inc.
06/25/15
20150176065

Detection of pna clamping


This invention provides methods and systems for detecting sequence variants in a sample nucleic acid. Methods include pna clamping/pcr using primers with binding moieties followed by capture and detection of amplicons on a solid support.
06/25/15
20150176061

Method for screening reagents used in pcr assays


The present invention relates to methods for screening of reagents used in the performance of polymerase chain reaction (pcr) assays. The invention has applications for genotyping, pathogen detection and in vitro diagnostics..
Roche Molecular Systems, Inc.
06/25/15
20150176060

Method for coding of multiple pcr reactions for assay recognition


The present invention provides for methods and compositions that use fluorescent dyes for the identification of reagents and solutions that are used to perform pcr assays.. .
Roche Molecular Systems, Inc.
06/25/15
20150176056

Electrospun fibers for protein stabliziation and storage


An electrospinning approach is disclosed for generating a dissolvable formulation of a reagent of interest in a nanoscale fiber medium. In one embodiment, the nanoscale fibers can incorporate and stabilize biological agents of interest, such as for storage at room temperature for extended periods.
General Electric Comapny
06/25/15
20150176054

Determining analyte concentration from variant concentration distribution in measurable species


A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time.
Bayer Healthcare Llc
06/25/15
20150176049

Determining usability of analytical test strip


A system for determining usability of an analytical test strip includes a sample chamber to receive a fluid sample, a reagent in the sample chamber having a moisture-varying impedance, and two detection electrodes contacting the reagent. A test meter applies an ac waveform across the reagent via the detection electrodes while measuring an impedance of the reagent.
Cilag Gmbh International
06/25/15
20150175812

Antimicrobial coatings


The disclosure provides polymers having antimicrobial activity and articles with the polymers coated thereon. The polymers include a first pendant group comprising a first quaternary ammonium component, a second pendant group comprising a nonpolar component, and a third pendant group comprising an organosilane component.
3m Innovative Properties Company
06/25/15
20150175725

Magnetic particle-polymer hybrid materials with functionalized polymers derived from norbornenyl reagents


A magnetic particle-polymer hybrid material can include: a substance having a structure of formula 1 or derivative or salt thereof: z(l-fp)m (formula 1), wherein: z is a magnetic particle smaller than 1 mm; m is a positive integer and defines the number of (l-fp) coupled to the z; l is a linker linked to the magnetic particle; fp is a functionalized polymer having: a first structure derived from a first norbornene compound linked to the magnetic particle through the l; and one or more monomeric units each including a second structure derived from a second norbornene compound, where one of the monomeric units is linked to the first structure through a saturated or unsaturated alkyl, each monomeric unit includes a functional group capable of binding with another substance.. .
The University Of Kansas
06/25/15
20150175718

Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells


A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound.
University Of Maryland, College Park
06/25/15
20150175714

Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells


A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound.
University Of Maryland, College Park
06/25/15
20150175681

Antibodies for the treatment of clostridium difficile-associated infection and disease


Provided herein are reagents, compositions, and therapies with which to treat clostridium difficile infection and related disease conditions and pathologies, such as clostridium difficile-associated diarrhea, resulting from infection by clostridium difficile bacteria and the enterotoxins produced by these bacteria. In particular, antibodies or antigen-binding fragments thereof that bind specifically to toxin a and/or toxin b of c difficile and neutralize the activities of these toxins; compositions comprising such antibodies; and methods of using the antibodies and the compositions are provided..
Progenics Pharmaceuticals, Inc.
06/25/15
20150174588

Methods for facilitating mineral extraction


There is provided methods for separating a target material from a raw material by mixing the raw material with water to form a slurry, adding a collector compound to the slurry to modify a relative hydrophobicity of a surface of the target material, adding a facilitator compound to enhance the modification of the relative hydrophobicity of the surface, and forming a froth including a concentrate of the target material. Disclosed methods may also include adding a facilitator compound to a raw material slurry that has been treated with a collector compound and a reagent for neutralizing the collector compound..
Chemtreat, Inc.
06/25/15
20150174440

Method for mechanochemical treatment of solid wastes containing perfluorinated or polyfluorinated compounds


A method for mechanochemical treatment of solid wastes containing perfluorinated or polyfluorinated compounds is provided. It belongs to the field of environment-polluting wastes treatment, and comprises the following steps: mixing the solid waste containing perfluorinated or polyfluorinated compounds with the defluorination reagent under normal temperature and pressure conditions, putting the mixture into a planetary high-energy ball milling reactor; adopting the mechanochemical reaction to realize high-effective degradation and defluorination of perfluorinated or polyfluorinated compounds.
Tsinghua University
06/25/15
20150174260

Amine-containing transfection reagents and methods for making and using same


There are provided for herein novel amine-containing transfection compounds and methods for making and using same. The compounds are generally obtained by reacting a primary amine with an unsaturated compound.
Life Technologies Corporation
06/25/15
20150174257

Methods and reagents for efficient and targeted gene transfer to monocytes and macrophages


The present invention provides a biosafe and useful vector to transfer genetic material to cd14+ mononuclear cells (monocytes and monocyte-derived macrophages) in an efficient and specific manner. The embodiment of the invention makes use of the chimeric human adenovirus vectors 5 carrying the short fiber of enterotropic ad40 to transfer genetic material to the target cd14+ mononuclear cells..
Fundacio Privada Institucio Catalana De Recerca I Estudis Avancats
06/25/15
20150174202

Methods and compositions for modulating beta cell proliferation


Methods and compositions are provided for modulating pancreatic islet β cell proliferation. Aspects of the methods include promoting β cell proliferation by providing agents that promote pdgfr signaling, or inhibiting β cell proliferation by providing agents that inhibit pdgfr signaling.
The Board Of Trustees Of The Leland Stanford Junior University
06/25/15
20150173408

Method of producing nanofibrillar cellulose with high absorptivity to fat and cholate


The invention provides a method for making nanofibrillar cellulose with high absorptivity to fat and cholate. According to the invention, dietary fiber material is activated by steam flash explosion and hydrolyzed sequentially by xylanase, laccase and cellulase.
Jiangnan University
06/18/15
20150170900

Apparatuses and methods for depositing sic/sicn films via cross-metathesis reactions with organometallic co-reactants


Disclosed herein are methods of forming sic/sicn film layers on surfaces of semiconductor substrates. The methods may include introducing a silicon-containing film-precursor and an organometallic ligand transfer reagent into a processing chamber, adsorbing the silicon-containing film-precursor, the organometallic ligand transfer reagent, or both onto a surface of a semiconductor substrate under conditions whereby either or both form an adsorption-limited layer, and reacting the silicon-containing film-precursor with the organometallic ligand transfer reagent, after either or both have formed the adsorption-limited layer.
Novellus Systems, Inc.
06/18/15
20150168430

Trapping reagents for reactive metabolites screening


The present invention provides compounds of formula (i) and (ii): (i) (ii) wherein r1, r2, r4, r5, r6, x and n are as defined herein, and wherein r3 is hydrogen or a sulfur protecting group. Compounds of formula (i) and (ii), wherein r is hydrogen, may be useful in methods for detecting a reactive metabolite in a sample, e.g., wherein the metabolite is generated from the metabolism of a test compound, and wherein the metabolite and the compound of formula (i) or (ii) react to form a detectable adduct, e.g., detectable by mass spectrometry..
Biogen Idec Ma Inc.
06/18/15
20150168427

Quantification of lipoproteins


Some aspects of this disclosure provide methods and reagents for the detection of apolipoproteins in a sample, for example, a sample obtained from a human subject. Some aspects of this disclosure provide protocols and reagents for the quantification of lipoproteins and lipoprotein particle populations comprising specific combinations of non-integral apolipoproteins and integral apolipoproteins, which is useful, inter alia, for the detection of diseases such as cardiovascular disease as well as an assessment of the risk of an individual to develop a disease..
President And Fellows Of Harvard College A Non-profit Corporation
06/18/15
20150168425

Method and agents to quantify proteins from tissues


As described herein, a robust generalizable method to accurately and sensitively quantitate proteins in tissues and fluids from human patients in a direct manner, not reliant on antibody reagents has been developed. This provides new and robust methods that are useful as biochemical outcome measures in human clinical trials.
Agada Biosciences, Llc
06/18/15
20150168423

Cardiovascular risk event prediction and uses thereof


The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the evaluation of risk of a caradiovascular (cv) event within 5 years. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to evaluate risk of a cv event within 5 years.
Somalogic, Inc.
06/18/15
20150168414

Methods and compositions for personalized medicine by point-of-care devices for fsh, lh, hcg and bnp


The present invention relates to biomarkers, methods, devices, reagent, systems and kits for the detection, diagnosis of ovarian cancer as well as for the monitoring of ovarian cancer progression and for monitoring the progress of various cancer treatments including ovarian cancer. The present invention also relates to point-of-care testing (poct) and methods for determining concentrations of biomarkers in a subject..
06/18/15
20150168397

Device for determining at least one analyte capable of being contained in a liquid sample


A device for determining the presence and/or amount of at least one analyte contained in a liquid sample, includes a capillary diffusion element (2) materialized on which are a zone (3) for depositing the liquid sample, an upstream release zone (4) and at least two capture zones (5). The device (1) also includes at least one downstream release zone (6) located downstream of at least one of the capture zones, which downstream release zone (6) includes at least one detection reagent conjugated to a visible and/or measurable marker; and the detection reagent of a release zone and/or the capture reagent of the additional capture zone(s), located directly downstream of the release zone, are suitable for binding specifically with the analyte and/or for binding specifically with one another, in order to form a complex that enables the determination of the analyte in the liquid sample at the additional capture zone(s)..
06/18/15
20150168395

In vitro diagnostic tool, membrane for in vitro diagnostic tool, and production methods of the tool and the membrane


Provided is an in vitro diagnostic tool configured to quantitatively or qualitatively detect a suspected substance in a test solution, the tool including: a first porous layer having a first surface and a second surface; a base sheet bonded to the first surface; a second porous layer bonded to the second surface; and a reagent configured to react with the suspected substance and carried in at least a part of the second porous layer, wherein: the first porous layer has a matrix structure of first nanofibers formed by electrostatic spinning; the second porous layer has a matrix structure of second nanofibers formed by electrostatic spinning; and a fiber diameter of the second nanofibers is smaller than a fiber diameter of the first nanofibers.. .
Panasonic Intellectual Property Management Co. Ltd
06/18/15
20150168388

Multiplexed analyses of test samples


The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule.
Somalogic, Inc.
06/18/15
20150168387

Color-produing diagnostic systems, reagents and methods


Provided herein are novel reagents and their use in color-producing detection systems for performing diagnostic tests and analytical assays.. .
Diagnostic Innovations, Llc
06/18/15
20150168382

Methods and reagents for evaluating the binding of mammalian sperm


The present invention provides a new apparatus/system for determining fertility of mammalian sperm based on a specific sperm-binding test that mimics sperm binding to an egg. The inventive apparatus/system comprises surface-modified beads with a compound or conjugates containing a carbohydrate sequence associated with the mammalian zona-pellucida (zp) glycoproteins..
The Curators Of The University Of Missouri
06/18/15
20150168373

Analytical device for determining a digestion parameter of a liquid sample


An analytical device for determining a parameter of a liquid sample, especially a digestion parameter, such as chemical oxygen demand, total carbon content or total nitrogen content, comprising a reactor, and measuring system for ascertaining the parameter of the liquid sample. A container system for storing samples, reagents and waste products in containers, a transport and dosing system for metering and transporting the sample and reagents from the containers into a metering container and for disposal of waste products from the metering container into a waste container, and a measuring transducer for registering a measured parameter correlating, measured value of the liquid sample mixed in the reactor, and measuring, system, in given cases, with one or more reagents is provided.
Endress + Hauser Conducta Gesellschaft Für Mess- Und Regeltechnik Mbh + Co. Kg
06/18/15
20150168361

Reagent kit, assay method, microfluidic device, and assay apparatus


An assay method enhances reliability of assay of a target material by removing interfering influence of non-target materials through controlling the concentration of the target material in a sample. A reagent kit, a microfluidic device, and a test apparatus are disclosed.
Samsung Electronics Co., Ltd.
06/18/15
20150168334

Biosensor strip


A biosensor strip includes a strip body, a working electrode and a chemical reagent layer, wherein the strip body has a conductive portion and a reaction channel. The partial wall that forms the reaction channel is a partial or an entire surface layer of the conductive portion.
Bionime Corporation
06/18/15
20150168294

Analyte monitoring systems and methods


A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam.
Optiscan Biomedical Corporation
06/18/15
20150167162

Apparatus and film formation


An apparatus and method for forming a thin film on a substrate by rpcvd which provides for very low levels of carbon and oxygen impurities and includes the steps of introducing a group va plasma into a first deposition zone of a growth chamber, introducing a group iiia reagent into a second deposition zone of the growth chamber which is separate from the first deposition zone and introducing an amount of an additional reagent selected from the group consisting of ammonia, hydrazine, di-methyl hydrazine and a hydrogen plasma through an additional reagent inlet into the second deposition zone such that the additional reagent and the group iiia reagent mix prior to deposition.. .
Gallium Enterprises Pty Ltd
06/18/15
20150167087

Biomarkers for post-traumatic stress states


The present invention relates generally to the detection or diagnosis of post-traumatic stress states in a subject, and provides methods, reagents, and kits useful for this purpose. Provided herein are biomarkers that are indicative of and/or diagnostic of post-traumatic stress states including ptsd..
Northwestern University
06/18/15
20150167069

Prostate cancer associated circulating nucleic acid biomarkers


The invention provides methods and reagents for diagnosing prostate cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated.. .
Chronix Biomedical
06/18/15
20150166985

Methods for correcting von willebrand factor point mutations


Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a nucleic acid encoding a mutant von willebrand factor protein to correct a point mutation associated with a disease or disorder, e.g., with von willebrand disease. The methods provided are useful for correcting a vwf point mutation within the genome of a cell or subject, e.g., within the human genome.
President And Fellows Of Harvard College
06/18/15
20150166984

Methods for correcting alpha-antitrypsin point mutations


Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a nucleic acid encoding a mutant α-antitrypsin protein to correct a point mutation associated with a disease or disorder, e.g., with chronic obstructive pulmonary disease (copd) disease. The methods provided are useful for correcting an α-antitrypsin point mutation within the genome of a cell or subject, e.g., within the human genome.
President And Fellows Of Harvard College
06/18/15
20150166983

Methods for correcting presenilin point mutations


Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a nucleic acid encoding a mutant presenilin1 protein to correct a point mutation associated with a disease or disorder, e.g., with familial alzheimer's disease. The methods provided are useful for correcting a psen1 point mutation within the genome of a cell or subject, e.g., within the human genome.
President And Fellows Of Harvard College
06/18/15
20150166982

Methods for correcting pi3k point mutations


Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a nucleic acid encoding a mutant pi3kca protein to correct a point mutation associated with a disease or disorder, e.g., with a neoplastic disorder. The methods provided are useful for correcting a pi3kca point mutation within the genome of a cell or subject, e.g., within the human genome.
President And Fellows Of Harvard College
06/18/15
20150166981

Methods for nucleic acid editing


Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of cas9 and nucleic acid editing enzymes or enzyme domains, e.g., deaminase domains, are provided.
President And Fellows Of Harvard College
06/18/15
20150166980

Fusions of cas9 domains and nucleic acid-editing domains


Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of cas9 and nucleic acid editing enzymes or enzyme domains, e.g., deaminase domains, are provided.
President And Fellows Of Harvard College
06/18/15
20150166611

Reagents and methods for identifying anti-hiv compounds


Single-molecule imaging techniques have been applied herein and have demonstrated the conformation states of hiv-1 env. The introduction of small organic fluorophores at selected positions within hiv-1 env that do not affect infectivity permits the detection of changes in inter-dye distances as a measure of conformational changes.
Cornell University
06/18/15
20150166542

Immunological reagents and uses therefor


The present invention provides a ligand which binds to mr1 wherein said binding results in binding of the mr1 to mait cells.. .
The University Of Melbourne
06/18/15
20150166352

Processes for the recovery of fluoride and silica products and phosphoric acid from wet-process phosphoric acid facilities and contaminated waste waters


In particular, in alternative embodiments, the invention provides for a method to recover silicofluoride and phosphate species from wastewaters, or barometric condenser waters, that are typically utilized in wet-process phosphoric acid facilities. The species are recovered via a continuous ion exchange approach that allows for economic recovery of the materials and especially with the silicofluoride component allows for the production of valuable industrial materials such as hydrofluoric acid and other fluoride salts as well as industrial-grade precipitated silica materials.
K-technologies, Inc.


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