|| List of recent Reagent-related patents
|Thermochromic polyvinyl alcohol based hydrogel artery|
A method of creating a thermochromic artificial blood vessel includes physically cross-linking a polyvinyl alcohol solution in a mold shaped to mimic a blood vessel to create an artificial blood vessel. The artificial tissue is then chemically cross-linked with a solution including a chemical cross-linking reagent.
|Process for producing 2,3,3,3-tetrafluoropropene|
The present invention relates, in part, to the discovery that, during the fluorination of certain fluoroolefm starting reagents, oligomerization/polymerization of such reagents reduces the conversion process and leads to increased catalyst deactivation. The present invention also illustrates that vaporizing such starting reagents in the presence of one or more organic co-feed reduces such oligomerization/polymerization and improves catalytic stability..
|Stabilized polymeric thiol reagents|
Disclosed are water soluble polymeric thiol reagents. Also disclosed are uses for the polymeric thiol reagents and methods for preparing the polymeric thiol reagents..
|Method for producing tetrahydropyran compound and intermediate thereof|
Disclosed is a method for producing a tetrahydropyran compound represented by general formula (5) shown in the scheme. Accordingly, a tetrahydropyran derivative is obtained in high yield and with high selectivity without using a highly toxic reagent, and an industrially useful method for producing a tetrahydropyran derivative and an intermediate thereof can be provided.
|Method for immobilizing membrane proteins on surfaces|
Disclosed herein are methods for immobilizing membrane proteins or membrane protein complexes on analytical surfaces, which in some aspects comprise: obtaining a membrane protein or membrane protein complex comprising a capture moiety; immobilizing the membrane protein or membrane protein complex on the analytical surface by means of the capture moiety; and stabilizing at least one of the secondary, tertiary, or quaternary structures of the immobilized membrane protein or membrane protein complex by crosslinking with a crosslinking reagent. Also disclosed are analytical surfaces, which in some aspects comprise: a membrane protein or membrane protein complex comprising a capture moiety, wherein the membrane protein or membrane protein complex is immobilized on the analytical surface by means of the capture moiety, and wherein at least one of the secondary, tertiary, or quaternary structures of the membrane protein or membrane protein complex is stabilized by crosslinking..
|Compositions and methods for treatment of mitochondrial diseases|
Methods and compositions are provided for the treatment of a mitochondrial disease in an individual with the mitochondrial disease. Aspects of the methods include administering an inhibitor of a mitochondrial transport protein to a subject having a mitochondrial disease.
|Plasmonic substrates for metal-enhanced fluorescence based sensing, imaging and assays|
Techniques for metal enhanced fluorescence include determining a calibration curve that relates concentration of a particular analyte to at least one of intensity or lifetime of fluorescent emissions at a functionalized substrate in response to incident light, for a plurality of known concentrations of the particular analyte mixed with a reagent. The functionalized substrate comprises a plasmonic substrate and a bioactive target molecule that has an affinity for the particular analyte.
|Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof|
The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
|Method of making highly porous, stable aluminum oxides doped with silicon|
The present invention relates to a method for making high surface area and large pore volume thermally stable silica-doped alumina (aluminum oxide) catalyst support and ceramic materials. The ability of the silica-alumina to withstand high temperatures in presence or absence of water and prevent sintering allows it to maintain good activity over a long period of time in catalytic reactions.
|Saccharide-containing protein conjugates and uses thereof|
Conjugates of a saccharide and a biomolecule, covalently linked therebetween via a non-hydrophobic linker and methods of preparing same are disclosed. Also disclosed are medical uses utilizing such conjugates.
|Genetic element that enhances protein translation|
The present invention provides isolated polynucleotides that can serve as translation enhancing elements and their use in protein expression reagents and methods.. .
|Reagents and methods for using human embryonic stem cells to evaluate toxicity of pharmaceutical compounds and other chemicals|
The invention provides biomarker profiles of cellular metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human embryonic stem cells (hesc) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds..
|Systems and methods for test strips with extended dynamic ranges|
An extended range test strip includes a simple system where the end user can determine the concentration of the analyte at high concentration with a single drop of whole blood. A single drop of blood spreads across a spreading layer and into multiple reagent stacks.
|Sample detection apparatus and detection method|
According to one embodiment, a sample detection apparatus including an insulating partition to divide a first and a second region, a pore formed in the partition, a first electrode arranged in the first region, a second electrode arranged in the second region, a power source configured to apply electrical current between the first and second electrode in a state in which a reagent containing a capture substance to be bound to a target and a tag particle bound to the capture substance is introduced into the first region together with a sample, and an electrolyte solution is introduced into the second region, a measurement unit configured to observe a change in a conductive state, and a detection unit to detect presence/absence of the target in the sample based on an observation result.. .
|Sulphur-containing chain transfer reagents in polyurethane-based photopolymer formulations|
The present invention relates to photopolymer formulations comprising: matrix polymers (a), obtainable by reacting at least one polyisocyanate component (a) and one isocyanate-reactive component (b); a writing monomer (b); a photoinitiator (c) a catalyst (d); and a sulphur-containing chain transfer reagent (e). A holographic medium that contains a photopolymer formulation according to the invention or can be obtained by using it, the use of a photopolymer formulation according to the invention for manufacturing holographic media, and a method for producing a holographic medium by using a photopolymer formulation according to the invention are also subject matter of the invention..
|Methods and reagents for detection and treatment of esophageal metaplasia|
The invention described herein relates to the treatment, detection, and diagnosis of various cancers, including esophageal or gastric adenocarcinoma and related metaplasias. The invention also includes a clonal population of barrett's esophagus progenitor cells and methods of using them for the treatment, detection, and diagnosis of barrett's esophagus..
|Multi-well rotary synthesizer|
An apparatus for synthesizing polymer chains includes a controller, a plurality of precision fit vials circularly arranged in multiple banks on a cartridge, a drain corresponding to each bank of vials, a chamber bowl, a plurality of valves for delivering reagents to selective vials, and a waste tube system for purging material from the vials. A purging operation can be selectively performed on one or more of the banks of vials.
|Blood coagulation analyzer|
In order to improve accuracy of determination of a blood coagulation time without requiring complicated work, a measurement unit 2 of a blood coagulation analyzer 1 irradiates a measurement specimen prepared by mixing a blood specimen and a reagent together, with lights of a plurality of wavelengths including light of a wavelength λ1 and light of a wavelength λ2, obtains information regarding an amount of transmitted light that transmits through the measurement specimen, and transmits the obtained information to a control device 4. The control device 4 calculates a blood coagulation time of the blood specimen based on information regarding a transmitted light amount based on light of the wavelength λ1.
|Analyzer with machine readable protocol prompting|
An analysis system utilizes a reagent with a machine-readable label for performing a biological assay on a sample. A scanner reads the label, and generates a scanner signal in response to reading the label.
|Addition of aluminum reagents to sulfate-containing waste stream reduce sulfate concentration|
The invention provides methods and compositions for detection and removal of sulfate from a liquid. The method provides much faster removal of sulfate than the prior art does and does so while requiring the use of far less aluminum.
|Custom ionic liquid electrolytes for electrolytic decarboxylation|
Methods, equipment, and reagents for preparing organic compounds using custom electrolytes based on different ionic liquids in electrolytic decarboxylation reactions are disclosed.. .
|Production of nanostructures|
Methods of producing nanowires and resulting nanowires are described. In one implementation, a method includes heating a reaction mixture including (i) a solvent; (ii) a metal-containing reagent; (iii) a templating agent; and (iv) a seed-promoting agent (spa) that is a source of halide anions, thereby producing a product that includes nanowires of the metal.
|Production of nanostructures|
Methods of producing nanowires and resulting nanowires are described. In one implementation, a method of producing nanowires includes energizing (i) a metal-containing reagent; (ii) a templating agent; (iii) a reducing agent; and (iv) a seed-promoting agent (spa) in a reaction medium and under conditions of a first temperature for at least a portion of a first duration, followed by a second temperature for at least a portion of a second duration, and the second temperature is different from the first temperature..
|Process for stabilizing waste|
The process for stabilizing wastes generally comprises blending spent or virgin fullers earth with a hazardous or non-hazardous sludge, soil or sediment to form a matrix. Next, the matrix is blended with a reagent capable of growing a calcium silicate hydrate or ettringite mineral.
|Using sortases to install click chemistry handles for protein ligation|
Methods and reagents for the installation of click chemistry handles on target proteins are provided, as well as modified proteins comprising click chemistry handles. Further, chimeric proteins, for example, bi-specific antibodies, that comprise two proteins conjugated via click chemistry, as well as methods for their generation and use are disclosed herein..
|Multiplexed analyses of test samples|
The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer).
|Apparatus and method for electrical detection of oligonucleotides through pore blockades|
Systems and methods for specific nucleic acid (na) sequence detection that do not rely on polymerase chain reaction (pcr) for target sequence amplification and do not require any special reagents other than a complementary sequence capture probe conjugated to spherical beads.. .
|Release reagent for vitamin d compounds|
A reagent composition for releasing vitamin d compounds bound to vitamin d-binding protein and an in vitro method for the detection of a vitamin d compound in which the vitamin d compound is released from vitamin d-binding protein by the use of this reagent composition as well as the reagent mixture obtained in this manner. Also disclosed is the use of the reagent compositions to release vitamin d compounds as well as a kit for detecting a vitamin d compound..
|Pipette tip set to be used in dispensing device and method for perforating reagent cartridge film using same|
A method which allows easy perforation of a film covering a well of a reagent cartridge which is set to a dispensing device is provided. A pipette tip set to be used in a dispensing device of an automatic analyzer together with a reagent cartridge in which a reagent for biochemical analysis is enclosed, includes: a dispensing pipette tip for dispensing the reagent enclosed in the reagent cartridge; a perforating pipette tip having a leading end surface inclined relative to a central axis thereof; and a rack configured to store the dispensing pipette tip and the perforating pipette tip together..
|Method for evaluating cell populations|
The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials.
|Readily isolated bispecific antibodies with native immunoglobulin format|
A bispecific antibody format providing ease of isolation is provided, comprising immunoglobulin heavy chain variable domains that are differentially modified in the ch3 domain, wherein the differential modifications are non-immunogenic or substantially non-immunogenic with respect to the ch3 modifications, and at least one of the modifications results in a differential affinity for the bispecific antibody for an affinity reagent such as protein a, and the bispecific antibody is isolable from a disrupted cell, from medium, or from a mixture of antibodies based on its affinity for protein a.. .
|Methods for removing nucleic acid contamination from reagents|
In general, the disclosed method can be used to remove contaminating microbes and nucleic acids from microorganisms-derived reagents, apparatus and processes (materials and apparatus) related to pcr (and rt-pcr), including sample prep reagents and materials that are used to isolate, purify and detect nucleic acids.. .
|Method for detecting the presence of a nucleic acid in a sample|
An automated method for detecting the presence of a nucleic acid in a sample, where the method is performed within a housing of a self-contained, stand-alone analyzer. The method includes purifying the nucleic acid after it has been immobilized on a magnetically-responsive solid support.
|Microfluidic flow cell assemblies and method of use|
A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. The fluidic connectors are thin film fluidic connectors capable of connecting to a fluid delivery system.
|Microfluidic flow cell assemblies for imaging and method of use|
A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. As configured, the subassembly comprises a substrate layer forms a flexible optically transparent lid which is capable of bending in either direction to alter the internal dimensions of the subassembly.
|Reagents, methods, and libraries for bead-based sequencing|
The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage.
|Method and apparatus to produce hydrogen-rich materials|
Hydrogen molecule (h2) has been indicated as a novel anti-oxidant reagent specifically targeting oh free radicals. This invention discloses the methods and apparatus that can be used to increase the hydrogen concentration in water, in beverages, and in other hydrogen absorbing materials through a sealed hydrogen gas producing chamber made of materials that have good hydrogen permeability and can withhold gas pressure.
|Method for the synthesis of 18f-labelled molecules|
The present invention provides a method for the synthesis of 18f-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention.
|Purification methods for betulonic acid and boc-lysinated betulonic acid, and organic synthesis of betulonic acid amides with piperazine derivatives|
The present invention provides a method of purifying betulonic acid contained the reaction product of organic synthesis of a jones oxidation reagent and betulin extracted from the bark of a birch, a method of preparing a piperazine betulonic acid amide derivative, which is used as a chemical having an antibacterial function, using the high-purity betulonic acid obtained by the purification method and a derivative prepared by this method, a method of purifying a boc-lysinated betulonic acid monomer ester contained in the reaction product of organic synthesis of lysine and the high-purity betulonic acid (starting material) obtained by the purification method, and a method of purifying boc-lysinated betulonic acid contained in the reaction product of hydrolysis of the high-purity boc-lysinated betulonic acid monomer ester.. .
|Methods of producing c-aryl glucoside sglt2 inhibitors|
Method for the production of c-aryl glucoside sglt2 inhibitors useful for the treatment of diabetes and related diseases. And intermediates thereof.
|Enzyme-degradable polymer and application thereof|
The present invention belongs to the biomedicine field and specifically concerns an enzyme-degradable polymer and the application thereof. To solve the problem of low sensitivity of the existing assay reagents, the present invention provides an enzyme-degradable polymer and the related application of the polymer.
|Unique halogen-induced cyclizations, reagents therefor, and compounds produced thereby|
This disclosure is related to halonium compounds useful for cyclization of polyenes, alkenoic acids, and alkenyl alkyl ethers, and halogenation of aromatic compounds. The synthesis of such halonium compounds, compounds made using such halonium compounds, and synthesis of natural compounds, including decalins, using the halonium compounds is also disclosed.
|Low k precursors providing superior integration attributes|
A deposition for producing a porous organosilica glass film comprising: introducing into a vacuum chamber gaseous reagents including one precursor of an organosilane or an organosiloxane, and a porogen distinct from the precursor, wherein the porogen is aromatic in nature; applying energy to the gaseous reagents in the chamber to induce reaction of the gaseous reagents to deposit a film, containing the porogen; and removing substantially all of the organic material by uv radiation to provide the porous film with pores and a dielectric constant less than 2.6.. .
|Kit for immuno-chromatography, reagent for immuno-chromatography, and method of detecting using them|
A kit for immunochromatography, having: a planar test strip having a test area and a reference area, the test area having a test purpose capturing substance, the reference area having a reference purpose capturing substance; fluorescent particulates provided with a binding property to a target substance, the target substance provided with a binding property to the test purpose capturing substance; and light absorbing particulates provided with a binding property to the reference purpose capturing substance.. .
|Pretreatment device and method for biochemical reaction|
A pretreatment device applied in sampling and providing a reaction space for biochemical reaction is disclosed. The pretreatment device includes a quantitative sampler being capable of collecting a constant volume of a sample; a devastating device having a hollow cylindrical structure coupled to the quantitative sampler to damage a thin-film like protective membrane of the quantitative sampler such that the reaction reagent flows out of the reagent container; a reaction device having a tubular structure and providing the reaction space for biochemical reaction of the reaction reagent and the sample; a hollow ring-shaped structure to position and stable the connection of the devastating device and the quantitative sampler with the hollow ring-shaped structure being coupled to the reaction device; and an anti-drain device preventing the reaction reagent and the sampler from flowing out before the biochemical reaction is completed..
|Specimen cup and method|
A specimen collection cup has a container. The container has a wall and a floor and is configured for receiving and retaining a specimen.
|Rapid fluorescence tagging of glycans and other biomolecules with enhanced ms signals|
Reagents comprising ms active, fluorescent molecules with an activated functionality for reaction with amines useful in tagging biomolecules such as n-glycans and uses thereof are taught and described.. .
|Apparatus for selective excitation of microparticles|
Nucleic acid microparticles are sequenced by performing a sequencing reaction on the microparticles using one or more reagents, selectively exciting the microparticles in an excitation pattern, optically imaging the microparticles at a resolution insufficient to resolve individual microparticles, and processing the optical images of the microparticles using information on the excitation pattern to determine the presence or absence of the optical signature, which indicates the sequence information of the nucleic acid. An apparatus for optical excitation of the microparticles comprises an interference pattern generation module that splits a first laser beam into second and third laser beams and generates the excitation pattern for selectively exciting the microparticles by interference between the second and third laser beams..
|In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes|
The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product.
|Methods and compositions for hematoxylin and eosin staining|
The present invention provide for solutions of a defined composition useful in a staining protocol, such as a hematoxylin and eosin staining protocol, when used at certain points of the staining protocol. The formulations of these defined solutions are such that carry-over of the solutions will not negatively impact, or preferably, will stabilize or favorably modify staining reagent solutions coming in contact with the solutions.
|Methods and reagents for determining isomeric analytes|
Methods include determining in a sample an amount of a first isomeric analyte and a second isomeric analyte. A first measurement value and a second measurement value are determined.
|Genomic dna extraction reagent and method|
The present invention is directed to a genomic dna extraction reagent and method for improved extraction of dna from biological tissue. The extraction reagent of the invention is mixed with disrupted biological tissue to form a dna extraction solute which is incubated in a dna extraction step.
|Open platform automated sample processing system|
An automated sample processing system having a sample input adapted to simultaneously receive a number of sample containers, a reagent input adapted to receive one or more new reagent supplies, a consumable input adapted to receive one or more new consumable supplies, a solid waste output adapted to receive used consumable supplies, a liquid waste output adapted to receive one or more used reagent supplies, and a processing center. The processing center includes a decapper adapted to remove a lid from at least one sample container, an aspirator adapted to remove a specimen from the at least one sample container and transfer the specimen to an output vessel, and a capper adapted to replace the lid on the at least one sample container.
A connector cap for a reagent bottle which can be pre-attached to a fully assembled synthesis cassette allows greater control in the assembly of the cassette and simpler operation for the end user. The connector cap may be incorporated onto reagent bottle or on vials to be used with automated synthesis cassettes..
|Fused metal nanostructured networks, fusing solutions with reducing agents and methods for forming metal networks|
Reduction/oxidation reagents have been found to be effective to chemically cure a sparse metal nanowire film into a fused metal nanostructured network through evidently a ripening type process. The resulting fused network can provide desirable low sheet resistances while maintaining good optical transparency.
|Assembly for determining the presence or absence of an analyte in a blood sample and analysis unit comprising such an assembly|
This assembly includes: a transportable support; a strip attached to the support and including an application area for applying the sample and at least one reagent required for the analysis; a piercing member for piercing the skin and a blood vessel; and a container for collecting, storing and returning the sample of human or animal blood. The piercing member is inserted into the container.
|Method for producing 5-hydroxymethyl-2-furfural or alkyl ether derivatives thereof using an ion exchange resin in the presence of an organic solvent|
The present invention relates to a method for producing a furan-based compound using an ion exchange resin in the presence of an organic solvent. In the method for producing a furan-based compound according to the present invention, a furan-based compound is made from an aldose-type hexose compound in the presence of an organic solvent by using an anion exchange resin and a cation exchange resin.
|Process to obtain a trifluoromethylating composition|
Process to obtain a trifluoromethylating composition which comprises the reaction between a copper (i) source and a base in the presence of a solvent and between the resulting cuprating reagent with fluoroform.. .
|Method for the synthesis of 18f-labelled biomolecules|
The present invention provides a method for the synthesis of 18f-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention.
|Selective aerobic alcohol oxidation method for conversion of lignin into simple aromatic compounds|
Described is a method to oxidize lignin or lignin sub-units. The method includes oxidation of secondary benzylic alcohol in the lignin or lignin sub-unit to a corresponding ketone in the presence of unprotected primarily aliphatic alcohol in the lignin or lignin sub-unit.
|Method of classifying antibody, method of identifying antigen, method of obtaining antibody or antibody set, method of constructing antibody panel and antibody or antibody set and use of the same|
The present invention relates to an isolated antibody against her1, an isolated antibody against cd147, an isolated antibody against cd73, and an isolated antibody against epcam; reagents and compositions including said antibodies; and uses of said reagents, compositions, and antibodies. The present invention also relates to nucleic acids and vectors expressing said antibodies.
|Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof|
The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment, particularly for reducing the risk of cardiovascular disease, especially coronary heart disease (such as myocardial infarction) and stroke. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents and kits for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents and kits for their detection..
|Rapid protein labeling and analysis|
The present invention provides methods and compositions for labeling, separating and analyzing proteins, particularly a specific protein of interest within a cell lysate or in a mixture of proteins. The proteins are labeled with an amine reactive or thiol reactive fluorescent dye, or an amine reactive fluorogenic reagent that becomes fluorescent upon reacting to amine groups located on the protein.
|Lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same|
Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region..
|Compositions and methods for in vitro diagnostic tests including sulfonic acid|
The invention provides compositions, kits, and methods for performing colorimetric analysis. A substrate is reacted to generate a chromogenic reaction product, and a reaction stop reagent that is a sulfonic acid is added to stop and stabilize the reaction product.
|Direct amplification and detection of viral and bacterial pathogens|
Provided are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids. Further provided are reagent mixtures that allow for direct amplification of a sample, without the step of nucleic acid extraction..
|Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same|
The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low action on maltose. The present invention relates to a polynucleotide encoding a soluble coenzyme-linked glucose dehydrogenase that catalyzes the oxidation of glucose in the presence of an electron acceptor and has an activity toward maltose of 5% or lower; a polypeptide encoded by the nucleotide sequence of the polynucleotide; a recombinant vector carrying the polynucleotide; a transformed cell produced using the recombinant vector; a method for producing a polypeptide comprising culturing the transformed cell and collecting from the cultivated products a polypeptide that links to fad to exert the glucose dehydration activity; a method for determination of glucose using the polypeptide; a reagent composition for determination of glucose; and a biosensor..
|Therapeutic agent for use in a method of treating psoriasis or atopic dermatitis|
The present invention provides a therapeutic agent for psoriasis or atopic dermatitis, and comprises anti-staphylococcus aureus antibodies as the active ingredient. A therapeutic agent for psoriasis or atopic dermatitis is specifically provided.
|Method and reagent for diagnosis and/or evaulation of progression of graft-versus-host disease|
Disclosed is a method of diagnosing graft-versus-host disease, comprising measuring the level of ccl8 protein in a sample obtained from a subject as an indicator for the diagnosis or course of graft-versus-host disease. Also a diagnostic reagent for graft-versus-host disease comprising an anti-ccl8 antibody is disclosed.
|Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof|
The present invention is based on the discovery of genetic polymorphisms that are associated with rheumatoid arthritis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
A test reagent container includes: a bottom part; a peripheral wall part on the periphery of the bottom part; a storage part which opens upward and with an internal diameter of an inner peripheral wall decreased with depth; a film which seals the opening of the storage part; a discharge channel which penetratingly passes from an inner bottom surface of the storage part to the bottom part of the container body; a projecting part formed downwardly projecting from the bottom part to seal an outlet of the discharge channel; a breakable part including a thick-walled part and a thin-walled part thinner than the thick-walled part formed on the periphery of the projecting part. The breakable part is broken when the projecting part is depressed from outside of the container, the projecting part is inserted into the inside of the discharge channel, and the sealed state of the outlet is released..
|System for managing inventory of bulk liquids|
A system for managing bulk liquids for an automated clinical analyzer. The system comprises (a) at least one local reservoir for storing a bulk liquid for impending use, (b) at least one container for holding a bulk liquid before the liquid is transferred to a local reservoir, and (c) a controller for monitoring the level of a bulk liquid in a local reservoir.