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Reagent patents



      

This page is updated frequently with new Reagent-related patent applications.




Date/App# patent app List of recent Reagent-related patents
05/19/16
20160139136 
 Rapid fluorescence tagging of glycans and other biomolecules with enhanced ms signals patent thumbnailRapid fluorescence tagging of glycans and other biomolecules with enhanced ms signals
Reagents comprising ms active, fluorescent molecules with an activated functionality for reaction with amines useful in tagging biomolecules such as n-glycans and uses thereof are taught and described.. .
Waters Technologies Corporation


05/19/16
20160139134 
 Method for analysis of compounds with amino group and analytical reagent therefor patent thumbnailMethod for analysis of compounds with amino group and analytical reagent therefor
The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-n-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity.
Ajinomoto Co., Inc.


05/19/16
20160139116 
 In vitro capture and analysis of circulating tumor cells patent thumbnailIn vitro capture and analysis of circulating tumor cells
This invention provides methods and compositions for capturing circulating tumor cells (ctcs) as well as various divergent ctc phenotypes using seprase-specific affinity reagents. Methods of analyzing ctcs and assessing their metastatic potential in vivo and in vitro are also disclosed..
The University Of North Carolina At Chapel Hill


05/19/16
20160139102 
 Paper microfluidic devices for detection of improvised explosives patent thumbnailPaper microfluidic devices for detection of improvised explosives
Paper microfluidic devices for testing for explosives are provided, along with methods of fabricating and using the same. One or more channels are formed on a paper substrate, and a test spot is formed in at least one of the channels.
The Florida International University Board Of Trustees


05/19/16
20160139072 
 Biosensor and manufacturing method therefor patent thumbnailBiosensor and manufacturing method therefor
A biosensor and a method for manufacturing the biosensor. The biosensor comprises an insulative substrate (1), an electrode system (2, 3, and 4), a reagent, and an insulating layer (5).
Lead (hk) Limited


05/19/16
20160139010 
 System and  processing biological specimens patent thumbnailSystem and processing biological specimens
A system for processing biological specimens mounted on microscope slides by adding and removing processing fluids from microscope slides by means of capillary action using a slide holder capable of holding multiple microscope slides, and a spacer positioned in between two slides of a slide pair to create a capillary gap. A capillary gap adjuster can be used to pinch and release one end of the slide pair to create a pulsatile action to mix the reagent within the capillary gap.

05/19/16
20160138452 
 Reagent dosing system and  dosing reagent patent thumbnailReagent dosing system and dosing reagent
A reagent dosing system for dosing a reagent into the exhaust gas stream of an internal combustion engine includes a reagent tank for storing a supply of reagent; an injector module including an atomising dispenser and a positive-displacement metering pump which draws reagent from the reagent tank and delivers it to the dispenser; a supply line coupling the reagent tank to the injector module; a dosing control unit operable to control the injector module to inject reagent into the exhaust gas stream; and an additional priming pump arranged, in use, to urge reagent along the supply line toward the injector module under selected conditions.. .
Delphi International Operations Luxembourg S.a.r.l


05/19/16
20160138098 
 Container accommodation body patent thumbnailContainer accommodation body
A container accommodation body includes: a package; a container that is accommodated and sealed in the package while accommodating and sealing a reagent for performing a nucleic acid amplification reaction; and a drying agent that is accommodated and sealed in the package.. .
Seiko Epson Corporation


05/19/16
20160138091 
 Methods and systems for determining spatial patterns of biological targets in a sample patent thumbnailMethods and systems for determining spatial patterns of biological targets in a sample
The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets.
Prognosys Biosciences, Inc.


05/19/16
20160138090 
 Determination of intracellular bacteria patent thumbnailDetermination of intracellular bacteria
This application pertains to methods for the whole-cell analysis of intracellular bacteria. The methods are capable of making a determination of whether or not a sample (e.g.
Stender Diagnostics


05/19/16
20160138085 

Cartridge set


A cartridge set includes: a first package; a cleaning container that is accommodated and sealed in the first package while accommodating and sealing a cleaning solution for cleaning a nucleic acid-binding solid-phase carrier to which nucleic acid adheres; a second package; an elution container that is accommodated and sealed in the second package while accommodating and sealing an elution solution which elutes the nucleic acid from the nucleic acid-binding solid-phase carrier; a third package; and a reaction container that is accommodated and sealed in the third package while accommodating and sealing a reagent for performing a nucleic acid amplification reaction, in which the first package has water permeability that is lower than that of the cleaning container, the second package has water permeability that is lower than that of the elution container, and the third package has water permeability that is lower than that of the reaction container.. .
Seiko Epson Corporation


05/19/16
20160138084 

Cartridge set


A cartridge set includes: a first package; a cleaning container that is accommodated and sealed in the first package while accommodating and sealing a cleaning solution for cleaning a nucleic acid-binding solid-phase carrier to which nucleic acid adheres; an elution container that is accommodated and sealed in the first package while accommodating and sealing an elution solution which elutes the nucleic acid from the nucleic acid-binding solid-phase carrier; a second package; and a reaction container that is accommodated and sealed in the second package while accommodating and sealing a reagent for performing a nucleic acid amplification reaction. The first package has water permeability that is lower than that of the cleaning container and the elution container.
Seiko Epson Corporation


05/19/16
20160138075 

Determining usability of analytical test strip


A system for determining usability of an analytical test strip includes a sample chamber to receive a fluid sample, a reagent in the sample chamber having a moisture-varying impedance, and two detection electrodes contacting the reagent. A test meter applies an ac waveform across the reagent via the detection electrodes while measuring an impedance of the reagent.
Cilag Gmbh International


05/19/16
20160138010 

Instrument for cassette for sample preparation


A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system..
Luminex Corporation


05/19/16
20160137963 

A microfluidic device with a diffusion barrier


The invention provides a microfluidic device for macromolecule amplification by sequential addition of liquid reagents. The device of the invention comprises a chip forming a plurality of reaction chambers each extending between an inlet and an outlet, each inlet being in fluid communication with a common junction via micro channels.
Danmarks Tekniske Universitet


05/19/16
20160137852 

Anti-fingerprint treatment reagent and method processing the same


An anti-fingerprint treatment reagent has an organic polydimethlysiloxane, a solvent and an additive. A surface of a metal base material is treated by the organic polydimethlysiloxane.
Xiamen Runner Industrial Corporation


05/19/16
20160137844 

Carbazole dioxazine pigment and a its preparation


The pigment is synthesized from 3-nitro-n-ethylcarbazole. The first step is nitration of 3-nitro-n-ethylcarbazole to form 3,6-dinitro-n-ethylcarbazole which is reduced to form 3-amino-6-nitro-n-ethylcarbazole.

05/19/16
20160137730 

Antibody drug conjugates


This application discloses anti-p-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating cancer using the antibodies, antigen binding fragments, and antibody drug conjugates.
Novartis Ag


05/19/16
20160137704 

Modified biotin, mutant streptavidin, and use thereof


It is an object of the present invention to provide a mutant streptavidin with a reduced affinity for natural biotin, and also to provide a modified biotin having a high affinity for the mutant streptavidin with a reduced affinity for natural biotin. According to the present invention, there is provided a reagent kit for use in treatments or diagnoses, which comprises: (a) a mutant streptavidin with a reduced affinity for natural biotin or biocytin; and a modified biotin having a high affinity for the above-described mutant streptavidin..
Savid Therapeutics Inc.


05/19/16
20160137669 

Preparation of grignard reagents using a fluidized bed


The present invention relates to a process of preparing a grignard reagent comprising reacting magnesium particulates in a fluid bed reactor. The present invention further relates to a continuous process comprising fluidizing magnesium particulates in a reactor, forming the grignard reagent continuously, and reacting the grignard reagent with a substrate..
Dpx Holdings B.v.


05/19/16
20160137629 

Compounds for binding to the platelet specific glycoprotein iib/iiia and their use for imaging of thrombi


The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (pet) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body.
Piramal Imaging Sa


05/19/16
20160136642 

A microfluidic device with pillars


The invention provides a microfluidic device for mixing liquid reagents, the device comprises, a chip forming at least one reaction chamber between a bottom and a top and extending between an inlet and an outlet. To enable manufacturing from less rigid materials, the device comprises pillars extending from the bottom to the top.
Danmarks Tekniske Universitet


05/12/16
20160133460 

Atomic layer deposition of films comprising si(c)n using hydrazine, azide and/or silyl amine derivatives


Provided are methods for the deposition of films comprising si(c)n via atomic layer deposition processes. The methods include exposure of a substrate surface to a silicon precursor and a co-reagent comprising a compound selected from the group consisting of n═n═n—r, r2n—nr2, and (r3si)qnh3-q, wherein q has a value of between 1 and 3, and each r is independently selected from organosilicons, c1-c6 substituted or un-substituted alkanes, branched or un-branched alkanes, substituted or un-substituted alkenes, branched or un-branched alkenes, substituted or un-substituted alkynes, branched or un-branched alkynes or substituted or un-substituted aromatics..
Applied Materials, Inc.


05/12/16
20160131674 

Sample analyzer


A sample analyzer is provided that does not require a plurality of reagent containers containing the same type of reagent to be connected, that can continue measurement even when a reagent container becomes empty, and that allows the timing of replacement of the reagent container to be recognized suitably. A reagent storage section is provided that is connected to a reagent container containing a reagent through a fluid channel and that stores the reagent transferred from the reagent container.
Sysmex Corporation


05/12/16
20160131671 

Identification calibration blood gas biochemical analysis system, and device


The present invention relates to a recognition and calibration method for the blood gas chemistry analytic system, which comprises the following steps: getting reagent information recorded in the two-dimension code glued to or printed on the test card or reagent package; extracting the basic information of the test card from the reagent information, examining the correctness of the usage of the test card and feeding back the error messages and exiting the test if the usage is incorrect; if the usage is correct, extracting the feature information of the test card from the reagent information, obtaining the feature parameters of the test card and setting them as the feature parameters of the present test; collecting the present test signals and processing the operation of computation and adjustment for the signals according to the feature parameters of the present test and thus, obtaining the test results.. .
Edan Instruments, Inc.


05/12/16
20160131668 

Materials and methods for rapid and specific detection of cocaine


The invention pertains to a rapid and specific aptamer-based method for one-step cocaine detection with minimal reagent requirements based on an aptamer sensor that reports the presence of cocaine via the displacement and unquenching of a bound fluorophore molecule. In certain embodiments, the invention provides novel aptamers, which have reduced background fluorescence, bind a fluorophore molecule tightly, and show an increased signal gain in the presence of cocaine..
The Florida International University Board Of Trustees


05/12/16
20160131665 

Srm/mrm assay for the insulin receptor protein


Specific peptides, and derived ionization characteristics of the peptides, from the insulin receptor protein (ir), and its isoforms ir-a and ir-b, that are particularly advantageous for quantifying the ir protein, ir-a isoform and/or ir-b isoform, directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
Expression Pathology, Inc.


05/12/16
20160131620 

Enhanced sensitivity of detection in electrospray ionization mass spectrometry using a post-column modifier and a microfluidic device


A microfluidic liquid chromatography-electrospray ionization (lc-esi) device is provided for enhancing the sensitivity of mass spectrometric detection of an analyte in a sample. The device is designed to drive effective intermixing of an analytical flow stream exiting a chromatographic stationary phase and a post-column modifier reagent.
Waters Technologies Corporation


05/12/16
20160131611 

Anion sensor


The present invention announces a method for extending the storage life of a test reagent for quantification of ionic components in samples by using an anion sensor. The purpose of the present invention is to provide an anion sensor, wherein the storage life of the anion sensor itself may be extended, to thereby extend the storage life of the anion sensor beyond that of conventional anion sensors.
Hitachi High-technologies Corporation


05/12/16
20160131590 

Biochip for measuring blood glucose levels, and blood glucose meter for smartphone, containing same


Disclosed are a biochip for measuring blood glucose levels and a blood glucose meter for a smartphone including the same. The biochip for measuring blood glucose levels includes: a substrate, one surface of which is provided with a blood glucose inflow region into which blood glucose flows and with a reaction region that is connected to the blood glucose inflow region and has a recess formed therein, a porous separator disposed on the blood glucose inflow region to face the surface of the substrate, and silica nanoparticles and a reaction reagent distributed on the reaction region of the substrate.
Gachon University Industry Academic Cooperation Foundation


05/12/16
20160131589 

Optical sensor element for analyte assay in a biological fluid, and manufacture thereof


Beginning with a sheet of optically transparent material, one may fabricate a great many shaped optical wafers, each in the form of a thin and essentially flat piece of optical material having a narrow cross-sectional width relative to length, and a sharply narrowed tip at one end. The fabrication process involves passing a sheet of optically transparent material through one or more operational steps wherein cutting, shearing, embossing, microperforating, or a combination thereof is performed.
Light Pointe Medical, Inc.


05/12/16
20160130644 

Thiolated nucleotide analogues for nucleic acid synthesis


The present disclosure provide systems, compositions, methods, reagents, kits and products for extending a nucleic acid that includes incorporating a nucleotide residue at a terminus of a nucleic acid using a polymerase enzyme and at least one nucleotide, wherein the at least one nucleotide includes a thiophosphate moiety, and wherein the at least one nucleotide is resistant to hydrolysis by phosphatase. In some embodiments, the nucleotide incorporation can be conducted in the presence of a phosphatase.
Life Technologies Corporation


05/12/16
20160130607 

Agents for improved delivery of nucleic acids to eukaryotic cells


New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes..
Molecular Transfer Inc.


05/12/16
20160130585 

Aptamers for the treatment of sickle cell disease


The present invention provides polynucleotide aptamers that selectively bind to and inhibit polymerization of sickle hemoglobin (hbs), pharmaceutical compositions comprising the same, methods of use for diagnostics and treatment of sickle cell disease, methods of use as capture reagents, and methods of rational drug design.. .
The Johns Hopkins University


05/12/16
20160130295 

Modular radiochemistry synthesis system


A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position.
The Regents Of The University Of California


05/12/16
20160130279 

Pathway specific assays for predicting irritable bowel syndrome diagnosis


The present invention provides antibodies and methods for preparing antibodies to metabolites in the serotonin, tryptophan, kynurenine pathways. The prepared antibodies have low cross-reactivity to related metabolites, and are useful reagents for specific and sensitive immunoassays the present invention also provides stable derivatives of various metabolites and short chain fatty acids.
Nestec S.a.


05/12/16
20160130223 

Electrophilic reagents for monohalomethylation, their preparation and their uses


R12=resin, naphthalene or substituted naphthalene.. .

05/12/16
20160129456 

The synthesis of new anionic surfactants and their use as collectors in froth flotation of non-sulphidic ores


The present invention relates to a compound obtainable by reacting an n-acyl neutral amino acid or a salt thereof, or an n-acyl neutral amino acid oligopeptide or a salt thereof with a monohydroxy monocarboxylic acid or a salt thereof. This compound is useful as a collector in a process for froth flotation of non-sulfidic ores, especially phosphate ores.
Akzo Nobel Chemicals International B.v.


05/12/16
20160129442 

Microfluidic mixing and reaction systems for high efficiency screening


Microfluidic devices are described that include a rigid base layer, and an elastomeric layer on the base layer. The elastomeric layer may include at least part of a fluid channel for transporting a liquid reagent, and a vent channel that accepts gas diffusing through the elastomeric layer from the flow channel and vents it out of the elastomeric layer.
Fluidigm Corporation


05/12/16
20160129441 

Thermal reaction device and using the same


An m×n matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method comprising using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block..
Fluidigm Corporation


05/12/16
20160129139 

Method for purification of 18f-labeled choline analogues


The present invention relates to a method for purification of 18f-labeled choline analogues in a solution injectable to a patient, prepared using non-gaseous synthesis paths, comprising a step of solid phase extraction (spe) purification using a solid support, wherein the solid support used in the solid phase extraction purification has the characteristic to retain impurities and reagents from the solution but not the 18f-labeled choline analogues.. .
Trasis S.a.


05/05/16
20160126079 

Method and device for ionizing particles of a sample gas flow


A device for ionizing sample particles of a sample gas flow comprises a first flow tube for providing the sample gas flow, and an introducing means for providing h2so4 molecules to an interaction region. In addition the device comprises a generator for producing reagent primary ions from particles of candidate reagent gas flow essentially in a primary ion production region.
University Of Helsinki


05/05/16
20160126077 

Method and reacting ions


A method of mass spectrometry is disclosed having a mode comprising: providing a source of precursor ions and reagent ions for reacting with said precursor ions; providing a reaction region downstream of said source; providing an ion mobility separator between said source and said reaction region; providing a bypass cell between said source and said reaction region for guiding ions from said source to said reaction region without the ions passing through said ion mobility separator; guiding said precursor ions from said source, through said ion mobility separator so that said precursor ions separate according to their ion mobility and into said reaction region; and guiding said reagent ions from said source, through said bypass cell and into said reaction region; wherein the reagent ions react with the precursor ions within the reaction region to produce product ions.. .
Micromass Uk Limited


05/05/16
20160125600 

Method of and measuring biometric information


A method of and an apparatus for measuring biometric information are provided. The method includes receiving an image of a biosensor including a reagent pad on which a sample is collected, and comparing brightness information of a reacting region of the reagent pad in the received image with reference brightness information in the received image to determine a value of a reagent reaction between the reagent pad and the sample..
Samsung Electronics Co., Ltd.


05/05/16
20160124008 

Automatic analyzer


According to an embodiment of the disclosure, the analyzer includes a reagent driving disk that accommodates a reagent configured for analysis and that transports the reagent to a desired position, and a fixed disk that has a reagent stand-by position in which to make a reagent container containing the reagent, temporarily stand by, and a magnetic particles stirring position for stirring magnetic particles. A portion of the reagent stand-by position is constituted by a loading system.
Hitachi High-technologies Corporation


05/05/16
20160124007 

Device and identification and monitoring of a reagent kit of an analytical system


A device is adapted to identify and monitor a reagent kit adapted for insertion into an analytical system, the device is positioned in the reagent kit and includes: apparatus for measuring the temperature of the reagent kit; apparatus for measuring the light level to which the reagent kit is subjected; apparatus for measuring the electric conductivity level of the reagent kit; means for measuring the triaxial acceleration to which the reagent kit is subjected; a multiparameter data-logger for logging the data obtained from the temperature, light, conductivity and acceleration measuring apparatus; apparatus for storage and short-range transmission of data identifying the reagent kit and the data obtained from the temperature, light, conductivity and acceleration measuring apparatus, in order to detect operational or non-operational conditions of the kit.. .
Altergon Italia S.r.l.


05/05/16
20160123983 

Hcv antigen-antibody combination assay and methods and compositions for use therein


The present invention generally relates to combination immunoassays, reagents and kits for simultaneous detection of hcv antigens and anti-hcv antibodies in a test sample.. .
Abbott Laboratories


05/05/16
20160123977 

Assay device with shared zones


Disclosed is an assay device for determining the presence and/or extent of one or more analytes in liquid sample containing a) first and second assays each comprising a flow-path having a detection zone for immobilising a labelled binding reagent, wherein detection of a labelled binding reagent at one or both detection zones is indicative of the presence and/or extent of one or more analytes; b) a shared reference zone; c) one or more light sources to illuminate the detection zones and the reference zone; d) one or more photodetectors to detect light from the detection zones and the reference zone, which photodetector/s generate a signal, the magnitude of which signal is related to the amount of light detected; and e) signal processing means for processing signals from the photodetector/s.. .
Spd Swiss Precision Diagnostics Gmbh


05/05/16
20160123974 

Immunochromatographic diagnosis kit


Provided is an immunochromatographic diagnostic kit which renders prompt diagnosis possible, has high analysis sensitivity, and gives test results with excellent reproducibility. The immunochromatographic diagnostic kit includes: a conjugate pad that contains a conjugate containing chromogenic particles which have an average particle diameter of 100-1,000 nm and attain a color intensity of 1.0-10.0, 10-90 wt % of the particles being derived from cellulose and 90-10 wt % of the particles being derived from a colorant; and a sample pad for an in vitro diagnostic reagent, the sample pad being constituted of nonwoven fabric that has a basis weight of 10-150 g/m2 and a thickness of 0.07-1.00 mm and comprises regenerated cellulosic fibers..
Asahi Kasei Fibers Corporation


05/05/16
20160123965 

Reagents, methods and devices to prevent aggregation in particle based tests for the detection of multimeric target molecules


The present invention relates to a method for preventing aggregation of detection particles in a test for detecting a multi-epitope target analyte comprising two or more similar or identical epitopes in a sample and/or for determining the concentration of the multi-epitope target analyte in a sample wherein the method comprises the step of applying a first capture entity which can specifically bind to at least one epitope on the multi-epitope analyte, characterized in that the first capture entity blocks the at least one epitope from binding to a detection particle. The invention further relates to a method wherein the detection of the multi-epitope target analyte comprises the use of a second capture entity, which can specifically bind to the same or similar epitope of the multi-epitope target analyte as the first capture entity.
Koninklijke Philips N.v.


05/05/16
20160123926 

Methods of isolating nucleic acids under reduced degradation condition


A method of isolating nucleic acids from a biological material, comprises applying the biological material on a substrate comprising one or more cell lysis reagents impregnated therein; applying a fluid to the biological material applied on the substrate; extracting the nucleic acids from the biological material applied on the substrate; and collecting the extracted nucleic acids in a substantially intact form, wherein the collected nucleic acid has a molecular weight greater than or equal to 20 kb.. .
General Electric Company


05/05/16
20160123918 

Sensor and removing interfering substance


A technique is provided, wherein any influence, which would be otherwise exerted on a reaction of an objective substance caused by a reagent enzyme by an interfering substance contained in a specimen, is suppressed in relation to an electrochemical sensor for measuring the objective substance contained in the specimen. A sensor comprises a substrate; a detecting unit which is provided on the substrate and which detects an objective substance; a filter which covers the detecting unit, which permits permeation of the objective substance on one hand, and which regulates permeation of an interfering substance contained in a sample on the other hand; and removing unit which removes the interfering substance adhered to the filter..
Arkray, Inc.


05/05/16
20160123917 

Sensor and removing interfering substance


A technique is provided, wherein any influence, which would be otherwise exerted on a reaction of an objective substance caused by a reagent enzyme by an interfering substance contained in a specimen, is suppressed in relation to an electrochemical sensor for measuring the objective substance contained in the specimen. A sensor comprises a substrate; a detecting unit which is provided on the substrate and which detects an objective substance; a filter which covers the detecting unit, which permits permeation of the objective substance on one hand, and which regulates permeation of an interfering substance contained in a sample on the other hand; and removing unit which removes the interfering substance adhered to the filter..
Arkray, Inc.


05/05/16
20160122815 

Semiconductor device and manufacturing method thereof


In the field of the next generation dna sequencer, a method for integrating very high sensitive fet sensors having side gates and nanopores as devices used for identifying four kinds of base and for mapping the base sequence of dna without using reagents, and a semiconductor device having selection transistors and amplifier transistors respectively corresponding to the fet sensors having side gates and nanopores respectively so as to be able to read the variation of a detection current based on the differences among the charges of the four kinds of base without deteriorating the detection sensitivity of the fet sensor, are presented.. .
Hitachi, Ltd.


05/05/16
20160122808 

Method for detecting the presence of a nucleic acid in a sample


An automated method for detecting the presence of a nucleic acid in a sample, where the method is performed within a housing of a self-contained, stand-alone analyzer. The method includes purifying the nucleic acid after it has been immobilized on a magnetically-responsive solid support.
Gen-probe Incorporated


05/05/16
20160122804 

Reducing dna damage during sample preparation and sequencing using siderophore chelators


Embodiments disclosed herein provide reagents and kits for nucleic acid preparation comprising a siderophore. Embodiments disclosed herein provide methods for preparing a nucleic acid library, which comprise: providing a plurality of nucleic acid molecules from a sample; and manipulating the plurality of nucleic acid molecules in a reagent for nucleic acid preparation comprising a siderophore.
Illumina Cambridge Limited


05/05/16
20160122801 

Sequencer pretreatment device and method thereof


A sequencer pretreatment device includes a suction and discharge mechanism, a nozzle head having a nozzle for mounting a dispensing tip, a container group for accommodating liquids including magnetic particle suspension, a moving mechanism for causing relative movement between the nozzle and the container group, and a magnetic unit that exerts a magnetic field to the mounted dispensing tip. A method includes an extraction step of mixing a sample, extraction reagent solution, and magnetic particle suspension in the container group and extracting nucleic acid, a fragmentation producing step of fragmentating the nucleic acid by mixing with fragmentation solution accommodated in the container group and producing a fragment of a base sequence having the number of bases corresponding to a sequencer using magnetic particle suspension using the sequencer pretreatment device, and an amplification pretreatment step of dispensing a solution containing the fragment into the reaction vessel using the sequencer pretreatment device..
Universal Bio Research Co., Ltd.


05/05/16
20160122796 

Method for examining microorganisms


A method for examining microorganisms has a sampling preparation step including a fluorescence staining step of stirring and mixing certain amounts of a sample and a fluorescence staining reagent, a still standing step of leaving the solution after the fluorescence staining step to still stand for a certain time, and a dilution step of diluting the solution after the still standing step with a liquid that emits no fluorescence.. .
Satake Corporation


05/05/16
20160122416 

Antibody composition and buffer system therefor


A method for conjugating an isolated antibody to a label or derivatisation reagent, which method comprises contacting the antibody with an activated label or activated derivatisation reagent, or contacting the antibody with the label or derivatisation reagent in the presence of an antibody conjugation reagent, in a buffer system which comprises a monocarboxylic acid buffer compound other than glycine, bearing an amine substituent at the alpha or beta position.. .
Innova Biosciences Ltd


05/05/16
20160122383 

Peptide ligation


The invention relates to a process for introducing a thiol group a to a carbonyl group in a side chain of a protected a-amino acid, said protected a-amino acid having protecting groups on both the α-amine group and the a-carboxyl group. The process comprises a) if the side chain contains a functional group comprising a heteroatom bearing a hydrogen atom, protecting said functional group; b) treating the protected amino acid with a base of sufficient strength to abstract a hydrogen atom a to the carbonyl group, so as to form an anion; c) treating the anion with a reagent of structure pr-s-l in which l is a leaving group and pr is a thiol-protecting group, so as to introduce a pr-s- group a to the carbonyl group; and d) converting the pr-s- group to an h-s-(thiol) group.
The University Of Sydney


05/05/16
20160122196 

Use of polyols as scale control reagents in the mining processes


In the mining process, linear, branched, hyperbranched or dendrimeric polyols or mixtures thereof are employed as process stabilization aids for aqueous solutions and, or suspensions of metal salts. A specific application area of the polyols is the stabilization of bauxite liquor in the bayer process of producing alumina from bauxite..
Nalco Company


05/05/16
20160121325 

Instrument systems for integrated sample processing


An integrated system for processing and preparing samples for analysis may include a microfluidic device including a plurality of parallel channel networks for partitioning the samples including various fluids, and connected to a plurality of inlet and outlet reservoirs, at least a portion of the fluids comprising reagents, a holder including a closeable lid hingedly coupled thereto, in which in a closed configuration, the lid secures the microfluidic device in the holder, and in an open configuration, the lid is a stand orienting the microfluidic device at a desired angle to facilitate recovery of partitions or droplets from the partitioned samples generated within the microfluidic device, and an instrument configured to receive the holder and apply a pressure differential between the plurality of inlet and outlet reservoirs to drive fluid movement within the channel networks.. .
10x Genomics, Inc.


04/28/16
20160116478 

Reagent including anti-lgr6 antibodies for detection and diagnosis of cancer


The present invention provides a reagent for detection or diagnosis of cancer, which comprises a monoclonal antibody against lgr6 or a fragment of the antibody.. .

04/28/16
20160115525 

Detection of hydroxymethylcytosine bases


Methodologies for labeling the epigenetic modification 5-hydroxymethyl-cytosine (5hmc) along a dna molecule, and for imaging this epigenetic modification along a dna molecule are disclosed. Related compositions and reagents, and methods of preparing same are also disclosed..
Ramot At Tel-aviv University Ltd.


04/28/16
20160115523 

Methods and compositions for detection of small rnas


Currently, the circularization of small rnas is broadly regarded as an obstacle in ligation-related assays and explicitly avoided while short lengths of linear rna targets is broadly recognized as a factor limiting use of conventional primers in pcr-related assays. In contrast, the disclosed invention capitalizes on circularization of small rna targets or their conjugates with oligonucleotide adapters.
Somagenics, Inc.


04/28/16
20160115433 

Light energy supply for photobioreactor system


In one aspect, there is provided a photobioreactor system including a supply material processing sub-system, a reactor sub-system, a product material processing sub-system, and a solar energy supply sub-system. The reactor sub-system includes a photobioreactor configured for containing a reaction mixture that is operative for effecting photosynthesis upon exposure to photosynthetically active light radiation, wherein the reaction mixture includes photosynthesis reaction reagents.
Pond Biofuels Inc.


04/28/16
20160115252 

Labeled alginate conjugates for molecular imaging applications


Described are bifunctional nota-based derivatives capable of conjugating with alginate and with metal ions, as well as nota-alginate conjugates which can be labeled with stable or radioactive metal ions. Also described are conjugation methods of the bifunctional nota-based linker with alginate, and methods of using radiometal-labeled nota-alginate conjugates or other radio-labeled alginate conjugates as imaging reagents..
Bellerophon Bcm Llc


04/28/16
20160115172 

Method for producng tricyclic compound, and tricyclic compound capable of being produced by said production method


An object of the present invention is to provide a method for reproducibly producing a pyrrolopyrimidine ring-containing tricyclic compound in high yield with reduced formation of by-products, and to provide a novel tricyclic compound capable of being obtained by this production method. The present invention provides a method for producing a compound represented by formula (1) or a salt thereof, the method comprising the steps of: (i) causing an organic borane reagent to act on a compound represented by formula (2) or a salt thereof, and (ii) performing an intramolecular cyclization reaction of the reaction product of step (i) above using a zerovalent palladium catalyst in the presence of an alkali metal hydroxide..
Taiho Pharmaceutical Co., Ltd.


04/28/16
20160115122 

Process for a direct one-pot transformation of lutein to beta-cryptoxanthin via its acetate ester


The present invention relates to a process for converting commercially available lutein and/or lutein esters from extracts of marigold flower petals to (3r)-β-cryptoxanthin (major) and (3r,6′r)-α-cryptoxanthin (minor) in ratios ranging from 95:5 to 98:2 in a one-pot reaction at room temperature. Because the entire process can be carried out by employing safe and environmentally friendly food-grade reagents, the resulting mixture of these carotenoids is suitable for human consumption as a dietary supplement..
University Of Maryland, College Park


04/28/16
20160115028 

Plant for the production of monochloramine and process thereof


A process for the production of monochloramine characterized in that it provides for drawing a portion of water intended for the user and exclusively using the portion for preparing the monochloramine solution. The portion intended for the reaction of formation of monochloramine is subjected to a treatment on osmotic membrane, obtaining osmotized water.
Acel S.r.l.


04/28/16
20160114317 

Device and system for sampling and analyzing a liquid specimen


A system for sampling and analyzing a liquid specimen includes a device and a reagent container that can be pre-filled with an analytical reagent. The device may have a sample collecting system for collecting a predetermined volume of the liquid specimen, and a container for analyzing the liquid specimen collected by the sample collecting system.

04/28/16
20160114056 

Enzymatic conjugation of polypeptides


One embodiment relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions..
Innate Pharma


04/21/16
20160113121 

Patterning of electroless metals by selective deactivation of catalysts


Methods and devices for patterning electroless metals on a substrate are presented. An active catalyst layer on the substrate can be covered with a patterned mask and treated with a deactivating chemical reagent, which deactivates the catalyst layer not covered by the mask.

04/21/16
20160111585 

Method of absorber surface repairing by solution process


Methods and systems for repairing oxidation of cigs surfaces during manufacture of a cigs solar cell are generally disclosed. Oxidation of an absorber reduces the photoluminescence intensity of the cigs surface.

04/21/16
20160109462 

Tuberculosis biomarkers and uses thereof


The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection, treatment and diagnosis of tuberculosis (tb). In one aspect, the present application includes the identification of biomarkers that can be used alone or in various combinations for the detection of tb, including those set forth in tables 1, 2, 4, 5, and 8 to 12.

04/21/16
20160109447 

Reagents for hcv antigen-antibody combination assays


The present invention is directed to combination immunoassays, reagents and kits for simultaneous detection of hcv antigens and anti-hcv antibodies in a sample. The combination immunoassays of the present invention employ a non-ionic detergent that effectively exposes or releases the hcv core antigen from virions in a sample without interfering with the performance of other reagents such as the capture of anti-hcv antibodies by recombinant hcv antigens..

04/21/16
20160109438 

Protease-responsive peptide biosensors and methods for analyte detection


The present invention relates to peptide biosensors comprising (a) a protease recognition site; (b) an analyte binding site; and (c) a signaling moiety that can produce a detectable signal upon cleavage of the protease recognition site by a protease. Further encompassed are detection reagents that comprise said peptide biosensors in combination with a protease and methods for detecting the presence of an analyte molecule or screening of candidate compounds that modulate the binding of an analyte to a binding partner of the analyte..

04/21/16
20160109434 

Solid supported artificial cell membrane system


The present invention relates to an artificial cell membrane system comprising at least one membrane protein carrier associated with at least one membrane protein, wherein the at least one membrane protein carrier comprises or consists of a polymeric vesicle or a polymeric planar structure, and a solid support freely suspended in a fluid medium, wherein the at least one membrane protein carrier is attached to a surface of the solid support. A method of forming the artificial cell membrane system, and use of the artificial cell membrane system as a reagent are also provided..

04/21/16
20160109359 

Device for multiple tests from a single sample


A sample device and method for analyzing a sample are claimed. The sample device is a flat disc containing channels and wells for directing a sample to reagents located in the disc and for mixing the sample with the reagents.

04/21/16
20160109337 

Method and system for indicating time on a reagent container


An apparatus, system and method for monitoring fixation of a biological sample within a container. The apparatus system or method including a container having a fixation medium for fixation of a biological sample placed within the container and a label attached to the container, the label having a time indicator operable to automatically indicate a processing time of a biological sample placed within the fixation medium..

04/21/16
20160108473 

Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof


The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment, particularly for reducing the risk of cardiovascular disease, especially coronary heart disease (such as myocardial infarction) and stroke. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents and kits for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents and kits for their detection..

04/21/16
20160108459 

Automated isolation and chemical reaction(s) of nucleic acids


The present teachings relate to methods, kits and devices for performing automated sequential nucleic acid isolation and conversion/purification in a single closed system. In various embodiments, the present teaching enable a user to (i) load a device with test samples, reagents and consumables; (ii) select or program the device for the desired nucleic acid isolation and subsequent chemical treatment and/or conversion reaction(s) without further user intervention; and recovering the isolated and treated and/or converted nucleic acid at the conclusion of the program once the device is activated..

04/21/16
20160108457 

Method for monitoring anticoagulant therapy


A method of measuring the combined activity of both and only coagulation factors ii and x for the purpose of monitoring anticoagulant therapy, and kits for using the method. This is based on the hypothesis that the combined activity of factor ii and factor x (fii and fx) more accurately reflects clottability and the antithrombotic effect of vka anticoagulants in patients than conventional methods (eg pt, p&p).

04/21/16
20160108391 

Reagent compositions having pyridine-carboxylic acid-stabilized enzymes, as well as methods of making and using the same


Dry reagent compositions are disclosed that include one or more of an enzyme such as a dehydrogenase, a redox cofactor, an agent capable of eliciting at least one measurable change in a property of an indicator reagent in the presence of redox equivalents, an indicator reagent, and a pyridine-carboxylic acid, derivative or salt thereof. Also provided are diagnostic test elements including the reagent compositions for use in body fluid analysis.

04/21/16
20160108287 

Reactive 2-component adhesive film system


Reactive adhesive film, comprising (a) a polymeric film-forming matrix, (b) at least one reactive monomer or reactive resin, and (c) a reagent selected from the group consisting of a radical initiator and an activator, and a reactive 2-component adhesive film system for bonding various materials, such as metal, wood, glass and/or plastic. .

04/21/16
20160108065 

Branched oligoarylsilanes and producing same


A method of preparation of branched oligoarylsilanes is that a compound of general formula (iii) y-qk-siarn—r)3 (iii), where y stands for a residue of boronic acid or its ester or br or i, reacts under suzuki conditions with a reagent of general formula (iv) a-xm-a (iv), where a stands for: br or i, provided that y stands for a residue of boronic acid or its ester; or a residue of boronic acid or its ester, provided that y stands for br or i. A technical result is preparation of novel compounds, featured by a high luminescence efficiency, efficient intramolecular energy transfer from some molecular fragments to others, and an increased thermal stability..

04/21/16
20160108001 

Process for the stereoselective preparation of a pyrazole-carboxamide


The present invention relates to a process for the enantioselective preparation of the compound of formula (ib), which process comprises a) reducing the (e)- or (z)-form of a compound of formula (ii), with an enantioselective reagent to a compound of formula (iiia), and b) acylating the compound of formula (iiia) with the compound of formula (iv), or c) coupling the compound of formula (iv) with the compound of formula (ii), to give a compound of formula (v) and d) reducing compound of formula (v) in the presence of hydrogen, a catalyst and a chiral ligand, to the compound of formula (ib).. .





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