|| List of recent Reagent-related patents
|Polymers and plastics derived from animal proteins|
The invention is directed to a method for preparing a polymer derived from an animal protein, such as in a feedstock derived from animal by-products. The method involves hydrolyzing proteins present in a feedstock to obtain hydrolyzed proteins, wherein hydrolysis is conducted under conditions sufficient to digest the proteins and destroy pathogens; extracting a protein fraction from the hydrolyzed proteins; and treating the protein fraction with a crosslinking reagent to form the polymer.
|Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines|
This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (cppt), 1-cyanoimidazole (1-ci), 1-cyanobenzotriazole (1-cbt), or 2-cyanopyridazine-3(2h)one (2-cpo), or a functional derivative or modification thereof.
|Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines|
This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (cppt), 1-cyano-imidazole (1-ci), 1-cyanobenzotriazole (1-cbt), or 2-cyanopyridazine-3(2h)one (2-cpo), or a functional derivative or modification thereof.
|Method for preparing polymethylene polyphenyl polycarbamate|
A method for preparing polymethylene polyphenyl polycarbamate is provided, which is carried out through the condensation of phenylcarbamate with a methylating reagent under the catalyzation of a phase transfer acid catalyst. The method comprises: dissolving phenylcarbamate in a water-immiscible organic solvent to form a solution a; formulating an aqueous acid catalyst solution to fibrin a solution b; forming a reaction system comprising an organic phase and an aqueous phase by firstly adding a methylating reagent to the solution b and then mixing the solution a and the solution b or by adding the methylating reagent at the same time of mixing the solution a and the solution b or after mixing the solution a and the solution b; reacting the reaction system under stirring at a reaction temperature of 30° c.
|Methods for tagging dna-encoded libraries|
The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2′-substituted nucleotides, such as 2′-o-methyl or 2′-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation..
|Selective detection of norovirus|
A process for detecting norovirus nucleic acid in a sample is provided including producing an amplification product by amplifying a norovirus nucleotide sequence using a forward primer of seq id no: 1, 4, or 10 and a reverse primer of seq id no: 2, 5, or 11, and detecting the amplification product to detect norovirus in the sample. Also provided are reagents and methods for detecting and distinguishing gi or gil norovirus from other infectious agents.
|Methods and systems for sequencing long nucleic acids|
The present invention provides methods and systems for sequencing long nucleic acid fragments. In one aspect of the invention, methods, systems and reagent kits are provided for sequencing nucleic acid target sequences.
|Chloride ion fluorescence detection method and device, and use thereof|
A chloride ion fluorescence detection method and device, and a use thereof. The chloride ion fluorescence detection method utilizes chloride ions to influence luminescence characteristics of some photoluminescent substances to change the emission spectrum of the photoluminescent substances.
The present invention relates to reagents for separating proteins from detergent, reagents for detecting proteins in the presence of a detergent, and methods of using the same. The separating reagents contain a cyclic oligomer such as cyclodextrin and a cellulose derivative such as 2-hydroxyethyl cellulose.
|Lignocellulosic detection device|
A lignocellulosic detection device includes a lignocellulosic substrate and at least one detection reagent absorbed/coated to lignocellulosic tissue of the lignocellulosic substrate. A liquid specimen is in contact with the lignocellulosic substrate so as to be absorbed to the lignocellulosic tissue of the lignocellulosic substrate by capillary action and react with the detection reagent to achieve specimen detection.
|Cover member, method and treatment module for treating a biological sample on a substrate|
A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber.
|Buffered histology and cytology stains|
A composition for use in staining histological and cytological tissue and cell samples which includes a buffer component in a staining solution. Specifically, the invention relates to stains and methods of producing stains for histological and cytological microscopic evaluation of tissue and cells.
|Apparatus and method for analyzing blood clotting|
Systems, apparatuses and methods include evaluation the clotting time or strength of clotting in the presence of various clot-affecting reagents to obtain a profile of clot analysis for determination of bleeding complications. The various reagents may be included in a single cartridge for use in a blood clotting analysis device..
|Device and method for detecting substances present in biological or chemical samples|
The present invention relates to a device and a method for detecting substances which are present in biological or chemical samples, each substance producing an optically detectable signal upon reaction with a reagent. The device further comprises a sample carrier with at least two receptacles for receiving samples and is characterized in that at least part of the receptacle is equipped to receive at least 2 reagents each, and in that a camera for recording an image which shows at least one receptacle filled with at least two reagents for the detection of different substances, and an evaluation device for evaluating the samples which device is designed such as to evaluate each image by analyzing the signals in the image.
|Detection device, detection strip, and detection system|
A detection device applied for detecting body fluids includes a substrate and a plurality of anti-growth factor antibodies. The substrate includes at least one reaction portion.
|New method for evaluation of target in histological sample|
The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. In particular, the invention relates to a method and reagents for detection, visualization and quantification of a molecular target in immunostained histological samples using particular compositions of the target specific binding agent.
|Immunoassay test slide|
An immunoassay test slide for use in a dry chemistry analytical instrument includes a slide housing or case formed from two matable sections—a slide cover piece and a slide bottom piece. The slide housing defines an interior cavity in which is situated a sheet-like porous carrier matrix.
|Thermostable assay reagents|
There is provided a single-chain fusion protein comprising: (i) a thermostable kinase and (ii) a single-domain antibody or single-domain antibody fragment. There is also provided a method of preparing a single-domain antibody or single-domain antibody fragment, the method comprising: (i) expressing the single-domain antibody or antibody fragment as a single-chain fusion protein with a thermostable kinase, in a host cell such as e.
|Chaperone interaction assays and uses thereof|
In some aspects, the invention provides methods of identifying, detecting, and/or measuring protein-protein interactions. In some aspects, the invention provides methods of identifying and/or characterizing modulators of protein-protein interactions.
Methods and reagents for detection and analysis of nucleic acids are provided. Certain methods involves an encoding amplification in which a target sequence is associated with probe-binding sequences and optionally with indexing sequences, (2) an optional distribution step in which the product of the encoding amplification is split into multiple aliquots, and (3) a decoding and detection step in which the presence, absence, quantity, or relative amount of the target sequence in the aliquots is determined.
|Antigen presenting cancer vaccine|
The disclosure provides reagents, methods, and kits, for treating melanoma. The reagent encompasses interferon-gamma (ifn-gamma) responsive melanoma cells, where the cells are autophagic and non-apoptotic melanoma cells, and where the cells express mhc class if.
|Il-22 polypeptides and il-22 fc fusion proteins and methods of use|
The invention relates to il-22 polypeptides, il-22 fc fusion proteins and il-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to il-22 receptor associated reagents and methods of use thereof..
|Compounds for binding to the platelet specific glycoprotein iib/iiia and their use for imaging of thrombi|
The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (pet) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body.
|Method for extraction of beryllium from raw genthelvite (danalite, genthelvite, helvite) and bertrandite (chryosberl, euclase, bertrandite) mineral groups when processing the raw minerals (ores, concentrates)|
The invention relates to non-ferrous metallurgy and can be used for extracting beryllium from genthelvite and bertrandtte groups when processing the raw minerals (ores, concentrates) by heap and vat leaching. The objective of the invention is to disclose a method of teaching beryllium from danalite (fe8 (besio4) 6s2), genthelvite (zn8 (besio4) 6s2), helvite (mg8 (besio4) 6s2), chrysoberyl, euclase, and bertrandite, thus expanding the range of raw minerals used for processing and providing more economical production and improved environmental impact via use of an effective reagent at low temperatures by hydrochemical method.
|Flotation reagents and flotation processes utilizing same|
Methods of enhancing recovery of value sulfide and/or precious-metal minerals from an ore containing said minerals and a mg-silicate, slime forming mineral, and/or clay, and which is subjected to a froth flotation process, by adding to one or more stage of the froth flotation process a froth phase modifier having a polymer containing one or more functional groups, and optionally a monovalent ion modifier enhancing agent, thereby enhancing recovery of a value sulfide mineral and/or a precious metal-bearing mineral.. .
|Method for extraction of beryllium from the minerals of genthelvite group when processing the raw minerals (ores, concentrates)|
The invention relates to non-ferrous metallurgy and is used for extracting beryllium from genthelvites when processing the raw minerals (ores, concentrates) by heap and vat leaching. The objective of the invention is to disclose a method of leaching beryllium from danalite (fe8 (besio4) 6s2), genthelvite (zn8 (besiol) 6s2), and helvite (mg8 (besio4) 6s2), thus expanding the range of raw minerals used for processing and providing more economical production and improved environmental impact via use of an effective reagent at low temperatures by hydrochemical method.
|Automatic analysis system|
There is provided an automatic analysis system that dispenses samples and reagents into a plurality of reaction vessels to cause reaction and to measure the liquid resulting from the reaction. The system implements a method of handling capped sample containers such as vacuum blood collection tubes along transfer routes.
|Method and assembly for determining the temperature of a test sensor|
Methods and systems accurately determine an analyte concentration in a fluid sample. In an example embodiment, a receiving port receives a test sensor.
|Reagent dosing system and method of dosing reagent|
A reagent dosing system for dosing a reagent into the exhaust gas stream of an internal combustion engine includes a reagent tank for storing a supply of reagent; an injector module including an atomising dispenser and a positive-displacement metering pump which draws reagent from the reagent tank and delivers it to the dispenser; a supply line coupling the reagent tank to the injector module; a dosing control unit operable to control the injector module to inject reagent into the exhaust gas stream; and an additional priming pump arranged, in use, to urge reagent along the supply line toward the injector module under selected conditions.. .
|Process for producing 2,3,3,3-tetrafluoropropene|
The present invention relates, in part, to the discovery that, during the fluorination of certain fluoroolefin starting re-agents, particularly, 1,1,2,3-tetrachloropropene (1230xa), oligomerization/polymerization of such starting reagents reduces the conversion process and leads to increased catalyst deactivation. The present invention also illustrates that providing one or more organic co-feed to the fluooelefin starting stream reduces such oligomerization/polymerization and improves catalystic stability..
|Sialic acid derivatives|
An amine or hydrazide derivative of a sialic acid unit, e.g. In a polysaccharide, is reacted with a bifunctional reagent at least one of the functionalities of which is an ester of n-hydroxy succinimide, to form an amide or hydrazide product.
|Preparation of maytansinoid antibody conjugates by a one-step process|
The invention provides a one-step process for preparing a cell-binding agent cytotoxic agent conjugate comprising contacting a cell-binding agent with a cytotoxic agent to form a first mixture comprising the cell-binding agent and the cytotoxic agent and contacting the first mixture comprising the cell-binding agent and the cytotoxic agent with a bifunctional crosslinking reagent, which provides a linker, in a solution having a ph of about 4 to about 9 to provide a second mixture comprising the cell-binding agent cytotoxic agent conjugate, wherein the cell-binding agent is chemically coupled through the linker to the cytotoxic agent, free cytotoxic agent, and reaction by-products. The second mixture is then optionally subjected to purification to provide a purified cell-binding agent cytotoxic agent conjugate..
|Compositions and methods for immunomodulation|
The invention relates to methods and reagents for the treatment of immunological diseases. In particular, the invention relates to isoforms of the c4b-binding protein (c4bp) lacking beta chains as well as to fragments and peptides derived thereof and to the uses of these polypeptides for the treatment of immunological diseases such as immunoinflammatory disease, sepsis, an autoimmune disease, transplant rejection, graft-versus-host disease and a hypersensitivity disease.
|Exchange-induced remnant magnetization for label-free detection of dna, micro-rna, and dna/rna-binding biomarkers|
A method of using an exchange-induced remnant magnetization (exirm) technique for label free detection of short strands of nucleotides and cancer biomarkers, such as dna and microrna strands, dna/rna-binding biomarkers, and cancer-specific antigens, with high sensitivity, high specificity, and broad dynamic range. The method may provide a label-free approach aimed to facilitate high reliability, and to require a minimum amount of biochemical reagents..
|Method for detecting the presence of expanded spectrum b-lactamase-producing bacteria in a sample|
The present invention relates to a method for detecting the presence of expanded-spectrum β-lactamase (β-lactamase hydrolyzing expanded-spectrum cephalosporin)-producing bacteria in a sample, said method comprising the steps of: a) performing cell lysis on a test sample in order to obtain an enzymatic suspension; b) reacting a fraction of the enzymatic suspension obtained in step a) with a reagent kit, said reagent kit comprising—expanded-spectrum β-lactamase substrate selected from the group consisting of cephalosporins, aztreonam, and cephamycins, —a ph color indicator which will change color when the ph of the reaction mixture is comprised between 6.4 and 8.4, wherein a color change after step b) indicates the presence of expanded-spectrum β-lactamase-producing bacteria in the test sample. The invention also relates to a reagent kit, to a microtiter plate and to their uses in detecting the presence of expanded-spectrum β-lactamase producers in a test sample..
|Method for the determination of the concentration of vitamin b6 in a sample|
The invention relates to methods for the determination of vitamin b6 in samples as well as to reagent compositions for assaying a sample for vitamin b6 and to a test kit suitable for carrying out the methods according to the present invention. Further, the invention relates to the use of such methods for the application to different analyzing devices such as micro-titer plate readers and fully automated clinical chemistry analyzers (autoanalyzers)..
|Devices containing dried reagents for reconstitution as calibration and/or quality control solutions, and methods of production and use thereof|
Devices contain dried reagents that may be reconstituted and used in the calibration and quality control of sensors. Methods of producing and using the devices are also disclosed..
|Antibody capable of binding to specific region of periostin, and method for measuring periostin using same|
The present invention provides a method and a reagent for measuring periostin contained in a sample with improved accuracy, a method for improving accuracy in measurement of periostin, and a method of testing for pulmonary fibrosis or interstitial pneumonia with improved accuracy. The antibody of the present invention binds to at least one region selected from the group consisting of an emi region, an r1 region, an r2 region, and an r3 region of periostin or a cleavage product thereof.
|Method of nucleic acid amplification and measuring reagent and reagent kit therefor|
The object of the present invention is to provide a method that allows stable amplification of an internal standard material while maintaining an accurate assay value for a target nucleic acid in a nucleic acid detection system involving the use of an internal standard material and a reagent kit used therefor. The present invention relates to a method for nucleic acid amplification comprising preventing an internal standard amplification product from affecting amplification reaction of a target nucleic acid by performing amplification of an internal standard material prior to amplification of the target nucleic acid in the method for amplifying a target nucleic acid in a sample using an internal standard material and a reagent and reagent kit used therefor..
|Biosensor, thin film electrode forming method, quantification apparatus, and quantification method|
A biosensor is disclosed comprising a support; a conductive layer composed of an electrical conductive material such as a noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition..
|Antigen presenting cancer vaccine with gamma interferon|
The disclosure provides reagents, methods, and kits, for treating melanoma. The reagent encompasses interferon-gamma (ifn-gamma) responsive melanoma cells, where the cells are autophagic and non-apoptotic melanoma cells, and where the cells express mhc.
|Influenza a virus vaccines and inhibitors|
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (cpsf30) binding site on the surface of the influenza a non-structural protein 1 (ns1). Specifically, critical biochemical reagents, conditions for crystallization and nmr analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza a (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development..
|Microfluidic mixing and reaction systems for high efficiency screening|
Microfluidic devices are described that include a rigid base layer, and an elastomeric layer on the base layer. The elastomeric layer may include at least part of a fluid channel for transporting a liquid reagent, and a vent channel that accepts gas diffusing through the elastomeric layer from the flow channel and vents it out of the elastomeric layer.
|Lithium-porous metal oxide compositions and lithium reagent-porous metal compositions|
The invention relates to lithium reagent-porous metal oxide compositions having rli absorbed into a porous oxide. In formula rli, r is an alkyl group, an alkenyl group, an alkyny group, an aryl group, an alkaryl group, or an nr1r2 group; r1 is an alkyl group, an alkenyl group, an alkynyl group, an aryl group, an alkaryl group; and r2 is hydrogen, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, and an alkaryl group.
|Methods of determining analyte concentration having enhanced stability and hematocrit performance|
The present invention relates to methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 μg/mm2 of a mediator.
|Partitioned reaction vessels|
In view of the needs of the art, the present invention provides a reaction vessel having two distinct compartments, for separating solid-supported reagents. The present invention also provides a method to perform two step radiochemistry procedures in one reactor in a clean and 10 efficient manner.
|Particle-assisted nucleic acid sequencing|
This invention generally relates to particle-assisted nucleic acid sequencing. In some embodiments, sequencing may be performed in a microfluidic device, which can offer desirable properties, for example, minimal use of reagents, facile scale-up, and/or high throughput.
|Calorimetric microfluidic sensor|
A microfluidic sensor includes a microchannel that includes a reaction site with a reagent and a sample inlet. A liquid substance is received at the sample inlet and travels by capillary action to the reaction site.
|Multiplexed detection with isotope-coded reporters|
Some aspects of this invention provide reagents and methods for the sensitive, quantitative and simultaneous detection of target analytes in complex biological samples by liquid chromatography tandem mass spectrometry (lc ms/ms). Some aspects of this invention provide affinity reagents encoded with mass reporters for the sensitive and quantitative translation of an analyte of interest into a mass tag.
|Colorectal cancer associated circulating nucleic acid biomarkers|
The invention provides methods and reagents for diagnosing colorectal cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated. In some embodiments, the cna biomarkers are polynucleotide fragments, e.g., dna fragments, that are present at an elevated level in blood, e.g., in a serum or plasma sample, of a colorectal cancer patient in comparison to the level in blood, e.g., a serum or plasma sample, obtained from a normal individual who does not have colorectal cancer..
|Fluorescent dye compounds, conjugates and uses thereof|
The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.. .
|Method and device for determining properties of gas phase bases or acids|
Properties, such as concentrations, of gas phase bases or acids of a gas sample are determined by providing a sample gas flow, which includes the bases or acids to be determined as sample constituents, as well as also interfering constituents, which are other constituents than the sample constituents. Reagent ions are provided and introduced into the sample gas flow to arrange proton transfer reaction and thereby forming sample ions.
|Blood sample assay method|
The invention provides an enzymatic method for measuring the concentration of one or more analytes in the plasma portion of a blood derived sample, containing a first and a second component, where said second component interferes with the measurement of said first component. The method includes: i) diluting the sample with a reagent mixture; ii) substantially removing blood cells; iii) using a reagent which serves to temporarily prevent reaction of the second component, to generate a blocked second component; iv) causing the selective reaction of a constituent of each analyte to directly or indirectly generate detectable reaction products, where one of the analytes is the first component; v) monitoring the detectable reaction product or products; vi) relating an amount of the detectable product or products and/or a rate of formation of the detectable product or products to the concentration of each analyte, where the concentration of at least the first component is related to a corresponding detectable reaction product by means of estimating an un-measurable (fictive) endpoint.
|Cancer stem cell-specific molecule|
An objective of the present invention is to obtain two types of substantively homogeneous cancer stem cell populations which can be characterized using the cell surface marker lgr5, and to provide cancer therapeutics using an antibody against a cell membrane molecule specifically expressed in these cancer stem cells by identifying said cell membrane molecule. A further objective of the present invention is to provide, using an antibody against a cell membrane molecule specifically expressed in cancer stem cells, a reagent for detecting cancer stem cells, and a method for diagnosing and sorting cancer patients.
|Nucleic acid amplification|
Methods and compositions for the amplification of nucleic acids are disclosed. Amplification methods provided herein may be performed under isothermal conditions.
|Cell separation method|
The present invention provides methods and compositions for separating cells from a sample containing erythrocytes. The method is for recovering desired cells from a sample containing the desired cells, erythrocytes and undesired cells comprising: a) contacting the sample with a composition, said composition comprising: i) an erythrocytes aggregation reagent ii) at least one antigen recognizing moiety coupled to a magnetic particle, wherein said particle with said at least one antigen recognizing moiety specifically binds to at least one antigen specific for one or more undesired cellular components; b) applying simultaneously i) gravity sedimentation for sedimentation of erythrocytes and ii) a magnetic field gradient to said sample for immobilizing said magnetic particle generating a pellet and a supernatant phase, and c) recovering the desired cells from the supernatant phase.
|Soluble urokinase receptor (supar) in diabetic kidney disease|
Methods and compositions are provided for diagnosing and treating a diabetic kidney disease (dkd) in an individual. In aspects of the methods, the levels of soluble circulating urokinase receptor (supar) in the blood are measured to predict a dkd, diagnose a dkd, or provide a prognosis pertaining to a dkd.
|Personal blood glucose meter and abnormal measurement detection method using same|
A personal blood glucose meter and a method for sensing abnormal measurement using the same are disclosed. A personal blood glucose meter includes: a sensor strip for collecting and applying a blood sample, wherein the sensor strip includes a reagent; an electrode unit including a plurality of electrodes for receiving the blood sample from the sensor strip to generate electric current based on potential differences; an mcu for measuring currents value generated from the electrode unit to determine whether a glucose value of the blood sample is normal or abnormal; a potential supply unit for applying a predetermined potential to the electrode unit; and a display unit displaying resultant output from the mcu..
|Image processing apparatus, image processing method, information processing program, fluorescence observation system, and fluorescence navigation surgery system|
An information processing apparatus includes a storage unit, a cutting-out unit, and a display controller. The storage unit is configured to store an image of fluorescence emitted from an observation target area of a living body in a recording medium as a fluorescence image of the observation target area, the image of fluorescence being captured with a first definition, the image of fluorescence being obtained by applying excitation light to the observation target area to which a fluorescent reagent is added in advance.
|Hepatitis b viral variants with reduced susceptibility to nucleoside analogs and uses thereof|
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis b virus (hbv) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies.
|Novel process for the preparation of rebaudioside d and other related naturally occurring sweetners|
A novel process for preparation of rebaudioside d (rd), and other related naturally occurring sweeteners is provided. Rd is a natural sweetening agent which can decrease the bitter aftertaste of steviol glycosides.
|Nucleic acid ligand diagnostic biochip|
A nucleic acid ligand “biochip” is disclosed, consisting of a solid support to which one or more specific nucleic acid ligands is attached in a spatially defined manner. Each nucleic acid ligand binds specifically and avidly to a particular target molecule contained within a test mixture, such as a bodily fluid.
|Methods, reagents and kits for detection of nucleic acid molecules|
Methods, reagents and kits are provided for the production and use in detection assays of labeled nucleic acid molecules wherein a labeling molecule is attached directly to the 3′ end of the nucleic acid molecules.. .
There is provided a diagnostic reagent for use in the detection of m. Bovis or m.
|Systems for immunoassay tests|
This invention relates to a cartridge for an immunoassay test. The cartridge comprises (a) a probe well comprising a probe and a cap, the cap being in a closed position to enclose the probe in the probe well, wherein the probe has a bottom tip coated with analyte-binding molecules, (b) a sample well to receive a sample, (c) one or more reagent wells, (d) a plurality of wash wells each containing a first aqueous solution, and (e) a measurement well having a light transmissive bottom, the measurement well containing a second aqueous solution, wherein the openings of the sample well, reagent well, measurement well and wash wells are sealed.
|Insoluble carrier for use in anti-phospholipid antibody measurement reagent, anti-phospholipid antibody measurement reagent, and method for measuring anti-phospholipid antibody|
The present invention has an object to provide an insoluble carrier for an antiphospholipid antibody detection reagent having a high reactivity. The present invention also has an object to provide an antiphospholipid antibody detection reagent, and a method of detecting an antiphospholipid antibody.
|Method of fabricating testing reagent carrier through ionizing radiation|
A method is provided for modifying a radioactive carbon nanotube (cnt) carrier. Magnetic molecules are used.
|Method and assembly for determining the temperature of a test sensor|
An assembly determines an analyte concentration in a sample of body fluid. The assembly includes a test sensor having a fluid-receiving area for receiving a sample of body fluid, where the fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the sample.
|Reagent for detection and assessment of free chlorine in aqueous solution|
Provided is a heat dried reagent composition that is dry, methods of making it, and methods of using it. The heat dried reagent composition can be characterized by one or more of stability to the heat drying conditions; storage stability of the heat dried reagent composition; fast rehydration time; rapid assay kinetics; and assay precision.
|Reagent for detection and assessment of total chlorine in aqueous solution|
Provided is a heat dried reagent composition that is dry, methods of making it, and methods of using it. The heat dried reagent composition can be characterized by one or more of: stability to the heat drying conditions; storage stability of the heat dried reagent composition; fast rehydration time; rapid assay kinetics; and assay precision.
|Sample analyzer and method for loading reagent container|
Disclosed is a sample analyzer, comprising: a container storage configured to store a plurality of reagent containers; a setting chamber including within a setting portion on which at least one reagent container is set; a container detector for detecting the reagent container on the setting portion; a gate to open and close an entrance of the setting chamber; a transferring section configured to hold the reagent container on the setting portion and transfer it to the container storage; and a controller programmed to initiate the transferring section to transfer the reagent container from the setting portion to the container storage if the reagent container is set on the setting portion when the entrance of the setting chamber is closed by the gate.. .
|Fetal red blood cell detection|
A device for analyzing a maternal blood sample for quantification of the percentage of fetal red blood cells present with respect to the number of maternal red blood cells includes reagents for mixing with the biological sample, a microfluidic chip, 5 fluid reservoirs, a pumping system, an image acquisition system, an image analysis system, and an electronic control board. The microfluidic channel can confine the objects of interest to a monolayer, and may trap them in an organized array for analysis.
|Glutamate oxidase mutagenesis for diagnostic testing|
The described invention provides a method of generating a catalytically active oxidase enzyme preparation. The described invention also provides a means of generating reagents for a protease detection sensor which can use colorimetric, fluorescent, or electrochemical detection.
|Method and reagent kit for measuring activated partial thromboplastin time|
The present invention provides a method for measuring activated partial thromboplastin time. The method comprises: a first mixing step of mixing a blood plasma with a first reagent, wherein the first reagent comprises an activator and phosphatidylglycerol at a concentration equal to or greater than 25 μg/ml; a second mixing step of mixing a sample obtained in the first mixing step with a second reagent comprising a calcium salt; and a step of measuring coagulation time of the sample obtained in the second mixing step..
|Test substance assay method, test substance assay kit, and test substance assay reagent|
The test substance assay method includes (i) obtaining a mixed solution by mixing (a) first dry particles that are modified with first binding substances exhibiting binding properties specific to a test substance, have an average particle size of 100 nm to 200 nm, and have labels, and (b) second dry particles that are modified with second binding substances not exhibiting binding properties specific to the test substance, have an average particle size of 100 nm to 200 nm, and do not have labels with (c) a test sample solution containing the test substance; (ii) applying the mixed solution onto a substrate; (iii) causing the test substance to be trapped in a reaction site on the substrate that has third binding substances having binding properties specific to the test substance or has substances exhibiting binding properties to the first binding substances; and (iv) detecting the test substance.. .
|Sample analyzer, sample analysis method, and non-transitory storage medium|
To provide a sample analyzer capable of accurately obtaining the number of analyzable samples. When analyzing a sample collected from a subject, a cpu of the sample analyzer calculates the number of analyzable samples based on a remaining number of tests of a reagent set in a reagent holding section and the number of tests of the reagent to be consumed in measurement of a control, and causes a output section to display the number of analyzable samples.
|Nucleic acid amplification|
Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions.
|Nucleic acid amplification|
Methods and compositions for the amplification of nucleic acids are disclosed. Amplification methods provided herein may be performed under isothermal conditions.
|Methods for multiplexing recombinase polymerase amplification|
This disclosure provides for methods and reagents for rapid multiplex rpa reactions and improved methods for detection of multiplex rpa reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between rpa processes..
|Methods and compositions for labeling nucleic acids|
The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. In particular, the methods include a [3+2] cycloaddition between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent attached to a label.
|Methods and reagents for preserving rna in cell and tissue samples|
This specification relates to the field of molecular biology and provides novel methods and reagents for preserving and protecting the ribonucleic acid (rna) content of samples from degradation prior to rna isolation. This preservation may be accomplished without ultra-low temperature storage or disruption of the tissue..
|Chain transfer reagents in polyurethane-based photopolymer formulations|
The present invention relates to photopolymer formulations comprising: matrix polymers (a), obtainable by reacting at least one polyisocyanate component (a) and one isocyanate-reactive component (b); a writing monomer (b); a photoinitiator (c); a catalyst (d); and a chain transfer reagent (e). A holographic medium that contains a photopolymer formulation according to the invention or can be obtained by using it, the use of a photopolymer formulation according to the invention for manufacturing holographic media, and a method for producing a holographic medium by using a photopolymer formulation according to the invention are also subject matter of the invention..