|| List of recent Reagent-related patents
| Novelcrosslinking reagents, macromolecules, therapeutic conjugates, and synthetic methods thereof|
The invention provides novel chemical entities based on sugar alcohols. These new chemical entities are biocompatible and biodegradable.
| Process using grignard reagents|
The present invention relates to a process using grignard reagents for providing thio-triazolo group-containing compounds.. .
| Mrm/srm assay for death receptor 5 protein|
Specific peptides, and derived ionization characteristics of those peptides from death receptor 5 (dr5) protein are provided that are particularly advantageous for quantifying the dr5 protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring/multiple reaction monitoring (srm/mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
| Srm/mrm assay for the fatty acid synthase protein|
Specific peptides, and derived ionization characteristics of the peptides, from the fatty acid synthase (fasn) protein are provided that are particularly advantageous for quantifying the fasn protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
| Engineered polypeptide agents for targeted broad spectrum influenza neutralization|
The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (ha) polypeptides and/or ha receptors, and reagents and methods relating thereto.
| Process for determining the concentration of nucleic acids|
A process is disclosed for determining the concentration of nucleic acids in a sample in a microfluidic device. In at least one embodiment, the method includes a) introducing the sample into a first chamber, b) carrying out a number of cycles of an amplification reaction to be carried out in cycles for amplifying nucleic acids, c) transferring a defined volume which is a fraction of the volume of the first chamber and which has amplified nucleic acids into a second chamber and replacing the transferred defined volume with fresh reagents for the amplification reaction, d) determining the concentration of the amplified nucleic acids in a second chamber equipped with an element to determine concentrations, and e) repeating steps b)-d) until a concentration of the amplified nucleic acids which is within a range is determined in the second chamber.
| Methods and compositons for the treatment and diagnosis of cancer|
The invention relates to methods of detecting cancer in a sample obtained from a subject. The invention also provides kits and reagents for detecting cancer as well as therapeutics and methods of treating cancer..
| Reagents for improving pcr accuracy|
Provided herein are reagents for improving pcr accuracy.. .
| Novel reagents for directed biomarker signal amplification|
Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors.
| Low volume assay device having increased sensitivity|
An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample addition zone containing a reagent material; a detection zone in fluid communication with the reagent zone. The detection zone has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a capillary space between the projections capable of generating capillary flow parallel to the substrate surface.
| Unitized reagent strip|
The embodiments disclosed herein relate to unitized reagent strips for holding and transporting reagents and materials used in automated sample preparation and/or processing for biological and or chemical assays.. .
| Microfluidic system for nucleic acid analysis|
A microfluidic system for analyzing nucleic acid, the microfluidic system including a reagent supply device including a sample chamber into which a sample can be injected, one or more reagent chambers for containing one or more reagents for extracting nucleic acid from the sample, and a waste chamber in which the used reagent can be discarded; a binding-lysis chamber in which cells are captured from the sample and lysed to form a cell lysate containing nucleic acid; plurality of particles for cell binding disposed in the binding-lysis chamber; a plurality of rehydration chambers into which the cell lysate formed in the binding-lysis chamber can be distributed and mixed with a nucleic acid amplification reagent to form an amplification reaction mixture; a plurality of amplification chambers in which a nucleic acid amplification reaction is performed on the amplification reaction mixture introduced from the plurality of rehydration chambers; and a flow channel system including an outlet and a plurality of inlets connected to the reagent supply device and forming an integrated fluid flow between the binding-lysis chamber, the rehydration chambers, and the amplification chambers.. .
| Stable nad/nadh derivatives|
The present invention provides for stable nicotinamide adenine dinucleotide (nad/nadh) and nicotinamide adenine dinucleotide phosphate (nadp/nadph) derivatives of formula (i), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.. .
| Methods and kits for detecting mastitis|
Methods and kits for determining if one or more animals have mastitis and for monitoring animals and the quality of the milk they produce are disclosed. Kits and test assays disclosed are used to determine the quantity of proteasomes and proteins thereof, the activity of proteasome enzymes, the quantity of proteasome bound and regulating proteins, and the quantity of ubiquinated protein.
| Methods of diagnosing breast cancer|
The disclosed subject matter is based on the discovery that a mutation (a single nucleotide polymorphism or “snp”) in the gene encoding abraxas (also referred to as abra1, ccdc98 or fam175a), is associated with susceptibility to cancer, e.g., breast cancer. In particular, the disclosed subject matter is based on the identification of a heterozygous alteration in the abraxas gene that is associated with breast cancer and specifically correlated with familial cancer.
| Methods and compositions for enrichment of nucleic acids in mixtures of highly homologous sequences|
Provided are methods of enrichment and detection of target nucleic acids during target amplification in the presence of excess amounts of highly homologous sequences, said methods having substantial diagnostic utility (e.g., cancer diagnostics). Provided are amplification reaction mixtures having at least one cleavage-directing oligonucleotide, the respective binding sites of which, for the target and homologous sequences, include one or more nucleotide positions differing in sequence between the target homologous sequences.
| Method for enhancing extraction efficiency of mirna from cells by the addition of triton x-100|
The present invention relates to a method for improving detection efficiency of mirnas existing in cells in trace amounts by adding triton x-100. In accordance with the present invention, mirnas existing in a sample in trace amounts can be quantitatively analyzed in short time.
| Fluidic connectors and microfluidic systems|
Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels.
| Use of hydrophobic epoxide resin system for encapsulation of a instrument transformer|
Disclosed is the use of a curable composition for padding-free encapsulation of instrument transformers comprising (a) a cycloaliphatic epoxy resin, (b) a polyoxyalkylene diglycidylether (c) an oh-terminated polysiloxane, (d) a cyclic polysiloxane and (e) a non-ionic, fluoroaliphatic surface-active reagent, (f) a filler, (g) a hardener selected from anhydrides, (h) a curing accelerator selected from accelerators for anhydride curing of epoxy resins.. .
| Frazil ice conjugate assay device and method|
An improved apparatus and method for dispersion of a labeling conjugate in a diagnostic assay, the result being a one-step assay. By eliminating a conjugate pad as in conventional lateral diagnostic devices, and forming a frazil ice pellicle (fip), rehydration and flow are improved resulting in better reproducibility, improved sensitivity, and reduced costs of individual assay devices.
| Chelate free chemical decontamination reagent for removal of the dense radioactive oxide layer on the metal surface and chemical decontamination method using the same|
A chemical decontamination reagent containing a reducing agent, a reductive metal ion, and an inorganic acid is provided to remove a radioactive oxide layer on a metal surface. The reagent can dissolve the radioactive oxide layer on the metal surface effectively at a relatively low temperature and enables a simple process of contacting the reagent to the radioactive oxide, thus economically effective in terms of cost and time required for the process.
| Preparation of metal nanowire decorated carbon allotropes|
In the method of embodiments of the invention, the metal seeded carbon allotropes are reacted in solution forming zero valent metallic nanowires at the seeded sites. A polymeric passivating reagent, which selects for anisotropic growth is also used in the reaction to facilitate nanowire formation.
| Apparatus and methods for performing electrochemical reactions|
The invention is directed to apparatus and methods for delivering multiple reagents to, and monitoring, a plurality of analytical reactions carried out on a large-scale array of electronic sensors under minimal noise conditions. In one aspect, the invention provides method of improving signal-to-noise ratios of output signals from the electronic sensors sensing analytes or reaction byproducts by subtracting an average of output signals measured from neighboring sensors where analyte or reaction byproducts are absent.
|Method for the production of fluoromethyl esters of androstan-17 beta carboxylic acids|
Described herein are processes for the preparation of monofluoromethylated organic biologically active compounds, starting from protected intermediates and/or reagents to obtain compounds such as fluticasone propionate and fluticasone furoate, in presence of decarboxylating reagents xef2 and brf3, or using fch2sh as a reagent.. .
|Functionally integrated device for multiplex genetic identification|
A biochip for multiplex genetic identification is disclosed. An biochip for separating and detecting a plurality of dna fragments includes a set of inputs and chambers for receiving a sample matrix of genetic material and reagents needed to conduct a polymerase chain reaction amplification of the genetic material.
|Procedure and automatic apparatus for in vitro blood coagulation diagnostic tests|
Apparatus and processes for automated diagnostic testing may include cuvette dispensing, test sample dispensing, reagent dispensing, incubation, photo-optical measuring, and a control in operative communication with the cuvette dispensing unit, the test sample dispenser, the reagent dispenser, the incubation unit, and the measuring unit. A cuvette removal location, a reagent removal location, a measuring location, and a collection receptacle may be situated along a first common circular arc having first geometric center.
|Bilirubin hematolfluorometer and reagent kit|
A reagent kit for detecting bilirubin in a fluid sample. The reagent kit includes a body defining at least one fluid receiving well and an optical window positioned over each at least one fluid receiving well.
|Compositions and methods for cdna synthesis|
The present invention relates to methods and compositions for preparing cdnas, and more particularly, compositions having trehalose for synthesizing a cdna molecule or molecules from an mrna template or population of mrna templates under conditions sufficient to increase the detection sensitivity and cdna yield and to simplify and improve the reliability of reverse transcription. The reagent mixture comprises a ready to use reagent solution, wherein the solution comprises: (a) trehalose in a concentration between about 5% and about 35%; and (b) a viral reverse transcriptase selected from the group consisting of amv rt, rsv rt, mmlv rt, hiv rt, eiav rt, rav2 rt, aslv rt, rnaseh (−) rt, superscript ii rt, and thermoscript rt, in a buffer suitable for use in a reverse transcription reaction, wherein the buffer further comprises a co-factor metal ion and nucleoside triphosphates..
|Method and culture medium for enhanced detection of mycobacterium|
The present invention relates to an improved culture medium and method for the enhanced growth and detection of mycobacterium growth. The invention further relates to an improved mycobacterial reagent system or kit that can be used for the enhanced growth and detection of mycobacterium..
|Multiplex mrm assay for evaluation of cancer|
The current disclosure provides specific peptides, and derived ionization characteristics of the peptides from the estrogen receptor (er), progesterone receptor (pr), and/or antigen ki67 (ki67) proteins that are particularly advantageous for quantifying the er, pr, and/or ki67 proteins directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring/multiple reaction monitoring (srm/mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
|Compositions and methods for rt-pcr|
The present invention relates to methods and compositions having trehalose and dna polymerase for facilitating the rapid and efficient amplification of nucleic acid molecules and the detection and quantitation of rna molecules, and for increasing the detection sensitivity and reliability through generation of secure cdna molecules prior to gene-specific primer dependent amplification. The reagent mixture comprises a ready to use reagent solution, wherein the solution comprises: (a) trehalose in a concentration between about 5% and about 35%; (b) a viral reverse transcriptase; and (c) at least one dna polymerases, in a buffer suitable for use in a reverse transcription reaction, wherein the buffer comprises a co-factor metal ion and nucleoside triphosphates..
|Low symmetry molecules and phosphonium salts, methods of making and devices formed there from|
Synthesis of molecules and salts is disclosed having low average symmetry and their use in many applications, including but not limited to: as electrolytes in electronic devices such as memory devices including static, permanent and dynamic random access memory, as electrolytes in energy storage devices such as batteries, electrochemical double layer capacitors (edlcs) or supercapacitors or ultracapacitors, electrolytic capacitors, as electrolytes in dye-sensitized solar cells (dsscs), as electrolytes in fuel cells, as a heat transfer medium, high temperature reaction and/or extraction media, among other applications. In particular, synthesis methods and processes to form molecules and salts having low average symmetry using mixed grignard reagents are disclosed..
|Methods and compositions for regulating iron homeostasis by modulation of bmp-6|
Modulation of iron homeostasis by regulating bmp-6 activity is provided. Methods of using bmp-6 and bmp-6 protein-specific reagents, such as antibodies, for altering serum iron levels in humans are provided.
|Genetic polymorphisms associated with alzheimer's disease, methods of detection and uses thereof|
The present invention is based on the discovery of genetic polymorphisms that are associated with alzheimer's disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
|Variants of hepatitis b virus with resistance to anti-viral nucleoside agents and applications thereof|
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis b virus (hbv) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies.
The invention relates to a device (1) for closing an opening in a container lid, and to the use of said device (1) in a container lid that is provided for covering reagent vessel containers in automatic analysis apparatus. The closure device comprises a fastening element (2), a closure element (20), two levers (14), and a plurality of bearings (18, 16, 24)..
|Methods for the synthesis of polycyclic guanidine compounds|
The present invention provides methods for the synthesis of polycyclic guanidine compounds. In certain embodiments, provided methods include the step of contacting a described reagent with a triamine compound to provide a polycyclic guanidine compound..
|Methods for the synthesis of functionalized nucleic acids|
Described herein are methods for the synthesis of derivatives of thiosulfonate reagents. Said reagents have utility for the synthesis of phosphorothiotriesters from h-phosphonates in a stereospecific fashion..
|Process for ultra-sensitive quantification of target analytes in complex biological systems|
Antibody-free processes are disclosed that provide accurate quantification of a wide variety of low-abundance target analytes in complex samples. The processes can employ high-pressure, high-resolution chromatographic separations for analyte enrichment.
|Apparatuses and methods for depositing sic/sicn films via cross-metathesis reactions with organometallic co-reactants|
Disclosed herein are methods of forming sic/sicn film layers on surfaces of semiconductor substrates. The methods may include introducing a silicon-containing film-precursor and an organometallic ligand transfer reagent into a processing chamber, adsorbing the silicon-containing film-precursor, the organometallic ligand transfer reagent, or both onto a surface of a semiconductor substrate under conditions whereby either or both form an adsorption-limited layer, and reacting the silicon-containing film-precursor with the organometallic ligand transfer reagent, after either or both have formed the adsorption-limited layer.
A chemiresistive biosensor for detecting an analyte can include a high specific surface area substrate conformally coated with a conductive polymer, and a binding reagent immobilized on the conductive polymer, wherein the binding reagent has a specific affinity for the analyte. The conductive polymer can be deposited on a substrate by ocvd..
An automatic analyzer adapted to enhance sample/reagent dispensing accuracy, regardless of a difference in sample/reagent dispensing height of a dispensing probe. When the amount of sample in a sample container is small, tip height “h1” of a sample dispensing probe positioned immediately after it has aspirated the sample decreases below tip height “h′” of the sample dispensing probe positioned immediately before it discharges the sample.
|Sensor and package|
A fluid sensor comprises a formed plastic body and a reagent. The body has a top face with an integral first surface.
|Genetic test system|
There is provided a genetic test system provided with a dispensing means for dispensing a sample and a reagent to a reaction vessel and a vessel conveyance means for conveying the reaction vessel. The system further includes a plurality of nucleic acid amplification detection units, each including a temperature control means for accommodating a plurality of reaction vessels and performing temperature control for each accommodated position of the reaction vessel, a temperature monitoring means for monitoring a value of temperature to be controlled of the reaction vessel, and a light emission measurement means for measuring light emission of reaction liquid in the reaction vessel.
|Temperature-dependent insertion of genetic material into genomic dna|
The present invention provides improved methods and reagents for insertion of genetic material into genomic dna.. .
|Methods of using oligonucleotides comprising a molecular switch|
This invention relates to oligonucleotides comprising a molecular switch which may exist in an “open” or “closed” position. The molecular switch portion of the probe is particularly sensitive to the identity of sequences complementary to the molecular switch.
|Schiff-base conjugate of n, n-dibutyl-p-phenylenediamine with pyridoxal 5'-phosphate for improved homocysteine assays using pyridoxal 5'-phosphate-dependent enzymes|
A composition, method and kit for performing a two-reagent enzymatic homocysteine assay, wherein a single homocysteinase enzyme and a schiff-based conjugate of n,n-dibutyl-p-phenyldiamine (dbpda) with pyridoxal 5′-phosphate (plp) are used to measure total homocysteine in plasma or serum. The assay measures a chromophore reaction product of h2s and the dbpda released from the schiff-base conjugate in the presence of a fe+3 containing compound.
|Systems and methods for continuous flow pcr systems|
A liquid handling system of a pcr system is instructed to obtain a matrix of samples and reagents for a pcr experiment. A fluid pumping system of the pcr system is instructed to maintain a continuous flow of a transport fluid through a plurality of micro-channels that allows the mixture of the samples and the reagents producing a plurality of mixed sample droplets.
|Treatment of cancer with alk1 antagonists|
Methods for evaluating responsiveness of a subject having cancer to treatment with an activin receptor-like kinase 1 (alk1) antagonist are provided. Methods for selecting a subject for treatment with an alk1 antagonist based on the subject being identified as responsive to such treatment are also provided.
|Integrated high throughput system for the analysis of biomolecules|
Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activated or activatable. The affinity reagents bound to the surface of the affinity microcolumn further comprise affinity receptors for the integration into high throughput analysis of biomolecules..
|Assay apparatuses, methods and reagants|
Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format..
|Cellulose-solvent-based lignocellulose fractionation with modest reaction conditions and reagent cycling|
Embodiments of the present invention overcome the well-known recalcitrance of lignocellulosic biomass in an economically viable manner. A process and system are provided for the efficient fractionation of lignocellulosic biomass into cellulose, hemicellulose sugars, lignin, and acetic acid.
|Technique for cleaving out part of poly(a) chain and/or 3'-terminal sequence of mrna to inhibit translation reaction|
A method of inhibiting the translation reaction of a target gene, comprising cutting out a part of the poly(a) tail and/or 3′-terminal sequence of the target mrna is provided. Also provided are a kit for inhibiting the translation reaction of a target gene, comprising a reagent capable of cutting out a part of the poly(a) tail and/or 3′-terminal sequence of the target mrna; a cell in which the translation reaction of a target gene is inhibited by introduction thereinto of a reagent capable of cutting out a part of the poly(a) tail and/or 3′-terminal sequence of the target mrna; and a non-human organism in which the translation reaction of a target gene is inhibited by introduction thereinto of a reagent capable of cutting out a part of the poly(a) tail and/or 3′-terminal sequence of the target mrna..
|Method for preparation of aryl poly(oxalkyl) quaternary ammonium compound|
A method for preparation of an aryl poly(oxalkyl) quaternary ammonium compound is provided, said method comprising steps of: 1) reacting a phenol with a dihalopolyalkylene ether under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) halide; 2) reacting said arylpoly(oxalkyl) halide with an amination reagent under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) amine; 3) reacting said arylpoly(oxalkyl) amine with an alkylation reagent, to obtain an aryl poly(oxalkyl) quaternary ammonium compound; wherein r1 is h or a c1 to c16 alkyl group, located in the ortho, meta or para position; n is an integer of 2 to 6; r2 is h or a c1 to c16 alkyl group; r3 is h or a c1 to c16 alkyl group; r4 is a c1 to c16 alkyl group; x1 is br or cl; x is cl, br, or i. The preparation method according to the present invention requires low temperature and low pressure, the reaction time is short, and an overall yield can reach 75%.
|Processes for the preparation of thietanamine|
The present invention provides processes for the preparation of compounds of formula (i) including processes comprising a. Reacting a a compound comprising a thietane moiety in which the carbon atom at the 3 position of the thietane moiety is bonded to a nitrogen atom; wherein the nucleophile is selected the group consisting of: n3−, a sulfonamide having two hydrogen atoms bound to the nitrogen atom, a diimide having a hydrogen atom bound to the nitrogen atom or an anion thereof, nh2oh and nh3; and b.
|Methods for purifying pertussis toxin and peptides useful therefor|
The present invention relates to reagents and methods for purifying pertussis toxin (pt).. .
|Uniform, damage free nitride etch|
An integrated circuit may be formed by forming a sacrificial silicon nitride feature. At least a portion of the sacrificial silicon nitride feature may be removed by placing the integrated circuit in a two-step oxidized layer etch tool and removing a surface layer of oxidized silicon from the sacrificial silicon nitride feature using a two-step etch process.
|Dna chip with micro-channel for dna analysis|
A dna chip with micro-channel for dna analysis of dna included in an analyte according to a pcr method is a dna chip with micro-channel for dna analysis in which is silicon (first layer) and plastic (second layer) are laminated, wherein the second layer is formed on a partial area of the first layer, and the second layer includes: a reagent; a liquid transporting system; and a sensor, and the first layer includes a pcr reactor provided on an area on which the second layer is not formed.. .
|Rapid diagnostic device, assay and multifunctional buffer|
An improved rapid diagnostic device, assay and multifunctional buffer reagent are provided for the detection of a target analyte in a fluid test sample. The 2-step assay utilizes a dual component flow-through device comprising a test unit and a dried indicator reagent delivery unit capable of receiving the fluid sample and multifunctional buffer, respectively.
|Salmonella and/or e. coli enzyme test and/or liquid drop test for biological substances, on non-human samples|
A test kit and test apparatus are provided for the detection of enzymes excreted by broken or ruptured bacteria cells in various environments, such as in the field, soil extracts, produce washing, slaughter houses, food preparation area's and other related or non-related areas where a quick test or rapid test is needed to obtain qualitative results. The method utilizes various components which allow for the collection of a sample from suspected contaminated areas.
|Reagents and methods for bispecific antibody-based binding of target molecules|
The invention provides methods for delivery of payloads to targets in samples using non-sterically hindered complexes. The invention further provides reagents and kits for practicing the methods of the invention.
|Dna chip with micro-channel for dna analysis|
Provided is a dna chip with micro-channel for dna analysis, which has a structure in which a silicon layer (chip a) and a plastic layer (chip b) are laminated, wherein the chip a includes at least two pcr reactors connected in series in a micro-channel, and a filter between the pcr reactors, the chip b includes a reagent, a liquid delivery mechanism and a sensor in a micro-channel, and the reagent, liquid delivery mechanism and sensor can be changed according to a kind of an analyte and an object to be detected.. .
The invention provides a method of printing, onto a substrate (12), an array (14) of spots of reagent compositions for use in a chemical and/or biochemical analysis. The method includes displacing an array of reagent composition containing capillary tubes (22) arranged alongside one another from an inoperative position to an operative position in which open ends of the capillary tubes (22) simultaneously impinge against a substrate and thereafter displacing the array of tubes (22) from the operative position back to the inoperative position.
|Transdermal patch having ultrasound transducer for administering thrombolytic reagents to patients having a protein misfolding disease|
The present invention relates to a method and device for treating patients with a protein misfolding disease by chronically administering an effective dose of a thrombolytic reagent and/or a thrombolytic reagent regulator over an intermittent period of time. The thrombolytic reagents degrade the misfolded proteins that accumulate and that can become toxic in such patients.
|Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof|
The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease and in particular vt and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
|Multifunctional bacteriophage for delivery of therapeutic agents and imaging reagents|
This invention relates to modified bacteriophage useful for the delivery of macromolecular biopolymers and nanoparticles to target cells, e.g., disease cells, and their use in cell-selective identification and imaging, as well as the treatment and prevention of diseases and other medical conditions.. .
|Method and apparatus for automatic staining of tissue samples|
The present invention concerns an apparatus for staining tissue samples, said apparatus including a reagent section or reagent containers; at least one staining section or tissue samples, a robotic head or robotic element that may move reagent to a predetermined tissue sample, said robotic element being moveable above the reagent and the staining sections, a control element that may manage a staining process, a 2-d optical sensor to detect two-dimensional image data of a relevant property and that can feed the captured image data to the control element. By providing the robotic element with a 2-d optical sensor, a common image processor may be provided having multiple functions.
|Test tape cassette and analytical test tape therefor|
A test tape cassette is disclosed that includes a cassette housing and an analytical test tape. The test tape includes a plurality of analytical test elements, a spreading fabric for applying a body fluid, and an underlying reagent layer for detecting an analyte in the body fluid.
|Synthesis and surface functionalization of particles|
Provided are methods of controlling the shape and surface chemistry of nanoparticles, particularly ferrite nanoparticles. Methods for preparing non-spherical ferrite nanoparticles, including nanocubes, nanobars, nanoplates, and nanoflowers, are described.
|Preparation of maytansinoid esters|
Provided are efficient methods for direct coupling of a maytansinoid with a carboxylic acid to prepare a maytansinoid c-3 ester in high yield using a rare earth metal-based or trifluoromethanesulfonate-based lewis acid catalyst and a base together with a coupling reagent. Also provided are compositions used in such methods..
|Microfluidic device for nucleic acid extraction and fractionation|
Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the extraction and fractionation of dna molecules, from whole or lysed samples, in a single flow-through device.. .
|Sulfurization reagents on solid supports|
Described herein are novel solid-supported sulfurization reagents having the general structure: (i) wherein (p) is a polymer; x is a linker; r1 is an alkyl group, a cycloalkyl group, an aryl group, or a heterocycle; and r2 is an alkyl group, an aryl group, a methyleneacyloxy group having the formula —ch2—o—c(o)—r7, a methylene carbonate group having the formula —ch2—o—c(o)—or8, or a methylene carbamate group having the formula —ch2—o—c(o)—nr9r10, wherein r7 is a c1 to c20 hydrocarbon residue, r8 is any alkyl, cycloalkyl, aryl, or heteroaryl, and r9 and r10 are independently hydrogen, alkyl, cycloalkyl, aryl, or heteroaryl. Other embodiments include solid-supported sulfurization reagents having the structure of formula i, wherein (p) is a polystyrene-based solid support and x is an aromatic linker.
|Detection of ovarian carcinoma by assay for autoantibodies to multiple antigens|
Assays and reagents for the detection of autoantibodies to detect ovarian carcinomas are provided.. .
|Methods and compositions reducing target gene expression using cocktails of sirnas or constructs expressing sirnas|
The present invention concerns methods and compositions involving the production or generation of sirna mixtures or pools capable of triggering rna-mediated interference (rnai) in a cell. Compositions of the invention include kits that include reagents for producing or generating sirna pools.
|Somatostatin analogs with inhibitory activity to growth hormone release|
Provided are therapeutic and diagnostic somatostatin analogs including radiotherapeutic and radiodiagnostic reagents, and methods of making and use thereof.. .
|Thermal cycling apparatus and method|
A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom.
|Method for detecting pancreatic cancer|
This invention relates to a method for detecting pancreatic cancer using novel tumor markers. Specifically, the invention provides a method for detecting pancreatic cancer comprising measuring the presence or an amount of a polypeptide having an reactivity of binding via an antigen-antibody reaction to an antibody against caprin-1 protein in a sample separated from a subject, and to a reagent or kit for detecting pancreatic cancer comprising a caprin-1 protein or a fragment thereof, an antibody against the same, or a polynucleotide encoding the same..
|Molecular prognostic signature for predicting breast cancer metastasis, and uses thereof|
The present invention is based on the discovery of a unique 14-gene molecular prognostic signature that is useful for predicting breast cancer metastasis. In particular, the present invention relates to methods and reagents for detecting and profiling the expression levels of these genes, and methods of using the expression level information in predicting risk of breast cancer metastasis..
|Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules|
The present invention is directed to novel methods for rapidly and unambiguously identifying small organic molecule ligands for binding to biological target molecules. Small organic molecule ligands identified according to the methods of the present invention may find use, for example, as novel therapeutic drug lead compounds, enzyme inhibitors, labeling compounds, diagnostic reagents, affinity reagents for protein purification, and the like.
|Reagent for measuring degree of oxidative stress and method of measuring degree of oxidative stress|
The present invention provides a reagent for measuring a degree of oxidative stress that includes a compound represented by the following general formula (i) or a salt thereof, and a method of measuring a degree of oxidative stress using the reagent for measuring a degree of oxidative stress. In the general formula (i), r1, r2, r3 and r4 each independently represent a hydrogen atom, an ethyl group, an isopropyl group, a hydroxyalkyl group that has 1 to 4 carbon atoms, or a phenyl group, and at least one of r1, r2, r3 or r4 represents an isopropyl group, a hydroxyalkyl group having 1 to 4 carbon atoms, or a phenyl group..
|Rapid fluorescence tagging of glycans and other biomolecules with enhanced ms signals|
Reagents comprising ms active, fluorescent molecules with an activated functionality for reaction with amines useful in tagging biomolecules such as n-glycans and uses thereof are taught and described.. .