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Reagent patents



      
           
This page is updated frequently with new Reagent-related patent applications. Subscribe to the Reagent RSS feed to automatically get the update: related Reagent RSS feeds. RSS updates for this page: Reagent RSS RSS


Date/App# patent app List of recent Reagent-related patents
05/21/15
20150141687
 Reagent for enhancing generation of chemical species patent thumbnailnew patent Reagent for enhancing generation of chemical species
A reagent that enhances acid generation of a photoacid generator and composition containing such reagent is disclosed. Described is a reagent that generates a first chemical species in at least one of a composition including the reagent, a solution of the composition, and a film formed of the composition.
Toyo Gosei Co., Ltd.
05/21/15
20150141665
 Methods for preparing polymeric reagents patent thumbnailnew patent Methods for preparing polymeric reagents
The present invention provides among other things methods for preparing polymeric reagents, wherein the method comprises (a) providing an aromatic moiety bearing a hydroxy group, a first amino group and a second amino group; (b) reacting a functional group reagent with the hydroxy group to result in a hydroxy group bearing a functional group capable of reacting with an amino group of an active agent and resulting in a hydolyzable carbamate; and (c) reacting a plurality of poly(alkylene glycol) water-soluble polymers bearing a reactive group with the first amino group and second amino group to result in (i) a first amino group bearing a water-soluble polymer through a spacer moiety, and (ii) a second amino group bearing a second water-soluble polymer through a spacer moiety.. .
Nektar Therapeutics
05/21/15
20150141606
 Temperature controlled sol-gel co-condensation patent thumbnailnew patent Temperature controlled sol-gel co-condensation
Provided according to some embodiments of the invention are methods of making co-condensed macromolecules that include forming a reaction mixture by combining at least one reactant and at least one reagent at a first temperature at which the at least one reactant is substantially unreactive in the presence of the at least one reagent; raising the temperature of the reaction mixture to a second temperature at which the at lest one reactant is reactive in the presence of the at least one reagent, wherein the reaction of the at least one reactant in the presence of the at least one reagent produces co-condensed macromolecules such as co-condensed silica macromolecules.. .
Novan, Inc.
05/21/15
20150141291
 Self-contained biological assay apparatus, methods, and applications patent thumbnailnew patent Self-contained biological assay apparatus, methods, and applications
A self-contained, fully automated, biological assay-performing apparatus includes a housing; a dispensing platform including a controllably-movable reagent dispensing system, disposed in the housing; a reagent supply component disposed in the housing; a pneumatic manifold removably disposed in the housing in a space shared by the dispensing platform, removably coupled to a fluidic transport layer and a plurality of reservoirs, wherein the fluidic transport layer, the reservoirs, and a test sample to be introduced therein are disposed in the housing in the space separate from the dispensing platform; a pneumatic supply system removably coupled to the pneumatic manifold in the housing in a space separate from the dispensing platform; and a control system coupled to at least one of the dispensing platform and the pneumatic supply system, disposed in the housing.. .
Rheonix, Inc.
05/21/15
20150141259
 Aptamer-based multiplexed assays patent thumbnailnew patent Aptamer-based multiplexed assays
The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction..
Somalogic, Inc.
05/21/15
20150140675
 Potentiometric titration  a mixed acid solution patent thumbnailnew patent Potentiometric titration a mixed acid solution
The present invention provides a potentiometric titration method of calculating a content of each acid in a mixed acid solution. The potentiometric titration method includes steps as follows.
Shenzhen China Star Optoelectronics Technology Co. Ltd.
05/21/15
20150140667
 Method for measuring moisture in liquid crystals patent thumbnailnew patent Method for measuring moisture in liquid crystals
When measuring the liquid crystals under test, the present invention adding the liquid crystals under test to a mixed solvent to form a solvent under test; measuring the moisture in the liquid crystal measurement sample through a reaction reagent to achieve a measurement result; wherein the mixed solvent comprises a first solvent, and the first solvent is dissolved with the methanol of the reaction reagent mutually and dissolves the liquid crystals under test. In the present invention, the moisture in the liquid crystal can be fully released and achieve accurate measurements..
Shenzhen China Star Optoelectronics Technology Co. Ltd.
05/21/15
20150140622
 Reagents and methods for cyanobacterial production of bioplastics and biomaterials patent thumbnailnew patent Reagents and methods for cyanobacterial production of bioplastics and biomaterials
The present invention provides reagents and methods for biomaterial production from cyanobacteria.. .
Arizona Board Of Regents, A Body Corporate Acting For And On Behalf Of Arizona State University
05/21/15
20150140601
 Fixing tissue samples using nitrogen-containing compounds that release aldehydes patent thumbnailnew patent Fixing tissue samples using nitrogen-containing compounds that release aldehydes
A method (100) for fixing at least one tissue sample (1) is carried out using a tissue processor (10). The tissue sample (1) is introduced at a first temperature level and a first pressure level into a fixing reagent (2) containing at least one nitrogen-containing compound capable of pressure- and/or temperature-dependent release of at least one aldehyde.
Leica Biosystems Nussloch Gmbh
05/21/15
20150140584
 Reagent materials and associated test elements patent thumbnailnew patent Reagent materials and associated test elements
reagent materials and associated test elements are provided. In one embodiment, a test element having dual functionality includes a first coenzyme-dependent enzyme or a substrate for the first enzyme, a second coenzyme-dependent enzyme or a substrate for the second enzyme, and a coenzyme selected from the group consisting of thio-nad, thio-nadp, and a compound according to formula (i).
Roche Diagnostics Operations, Inc.
05/21/15
20150140582
new patent

Immunological test element with improved control zone


The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g. An enzyme, fluorescent or direct label etc.) wherein said conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e.
Roche Diagnostics Operations, Inc.
05/21/15
20150140576
new patent

Cancer specific glycans and use thereof


The present invention describes glycans, which are specifically expressed by certain cancer cells, tumours and other malignant tissues. The present invention describes methods to detect cancer specific glycans as well as methods for the production of reagents binding to said glycans.
Glykos Finland Oy
05/21/15
20150140567
new patent

Nucleic acid amplification


Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions.
Theranos, Inc.
05/21/15
20150140496
new patent

Electroless plating method using non-reducing agent


A conductive metal pattern can be formed in a polymeric layer that has a reactive polymer that comprises (1) pendant groups that are capable of providing pendant sulfonic acid groups upon exposure, and (2) pendant groups that are capable of reacting in the presence of the sulfonic acid groups to provide crosslinking. The polymeric layer is patternwise exposed to provide non-exposed regions and exposed regions comprising a polymer comprising pendant sulfonic acid groups.
05/21/15
20150140493
new patent

Compounders for enhancing generation of chemical species


A reagent that enhances acid generation of a photoacid generator and composition containing such reagent is disclosed. Also described is a method for manufacturing a device, the method including applying a liquid containing a composition to a member such that a coating film including the composition is formed on the member; and exposing the coating film to at least one of a first electromagnetic ray and a first particle ray such that a first portion of the coating film is exposed to the at least one of the first electromagnetic ray and the first particle ray while a second portion of the coating film is not exposed to the at least one of the first electromagnetic ray and the first particle ray..
Toyo Gosei Co., Ltd.
05/21/15
20150139974
new patent

Rca locus analysis to assess susceptibility to amd and mpgnii


The invention relates to gene polymorphisms and genetic profiles associated with an elevated or a reduced risk of alternative complement cascade deregulation disease such as amd and/or mpgnii. The invention provides methods and reagents for determination of risk, diagnosis and treatment of such diseases.
University Of Iowa Research Foundation
05/21/15
20150137372
new patent

Self forming barrier layer and forming


Methods for forming a self-forming barrier layer and the resulting devices are disclosed. Embodiments may include forming a metal line above a substrate, forming a reagent layer above the metal line and the substrate, forming a dielectric layer on the reagent layer, and transforming the reagent layer into a self-forming barrier layer..
Globalfoundries Inc.
05/21/15
20150135502
new patent

Reagent magazine with motor latch coupler


A motorized latch assembly includes an electric motor, an eccentric cam attached via gears to a shaft of the motor and a latch plate configured to lock the reagent cartridge to the coupler. The eccentric cam is rotated when the shaft of the motor rotates.
Colder Products Company
05/14/15
20150133665

Processes and intermediates in the preparation of morphine analogs via n-demethylation of n-oxides using cyclodehydration reagents


A high-yielding method for the n-demethylation of oxycodone- and oxymorphone-n-oxides by the reaction of these compounds with cyclodehydration reagents has been performed. This method has been utilized to improve the synthesis of various morphine analogs, such as naltrexone, nalbuphone and naloxone..
05/14/15
20150133645

Labeled alginate conjugates for molecular imaging applications


Described are bifunctional nota-based derivatives capable of conjugating with alginate and with metal ions, as well as nota-alginate conjugates which can be labeled with stable or radioactive metal ions. Also described are conjugation methods of the bifunctional nota-based linker with alginate, and methods of using radiometal-labeled nota-alginate conjugates or other radio-labeled alginate conjugates as imaging reagents..
05/14/15
20150133336

Methods for determining ligand binding to a target protein using a thermal shift assay


The present invention concerns a method of determining whether a non-purified sample contains a target protein bound to a ligand of interest comprising the steps of a) exposing the non-purified sample to a temperature which is capable of causing or enhancing precipitation of the unbound target protein to a greater extent than it is capable of causing or enhancing precipitation of the target protein bound to the ligand; and b) analysing said sample for the presence of soluble or native target protein using two or more affinity reagents capable of binding to said soluble or native target protein with a higher affinity than to an unfolded and/or insoluble form of said target protein. The invention particularly concerns the use of two affinity reagents (e.g.
05/14/15
20150133335

Detection of digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer by gene expression profiling


The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing genes with expression levels (in peripheral blood) that vary in association with digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer cases, compared with normal healthy subjects. Specifically, the method for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects.
05/14/15
20150133334

Detection of digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer by gene expression profiling


The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing genes with expression levels (in peripheral blood) that vary in association with digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer cases, compared with normal healthy subjects. Specifically, the method for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects.
05/14/15
20150133314

Reagents and methods for sequencing


The disclosure provides a plurality of nucleic acid sequences comprising multiple variants of a reference sequence. The disclosure further provides plasmids, cells, methods and kits comprising the same..
05/14/15
20150132861

Clinical diagnostic systems


A diagnostic system is provided herein that includes an instrument comprising an electrochemiluminescence (ecl) detector, and a cartridge configured to fit within a portion of the instrument, wherein the cartridge includes at least one reagent including an ecl label and a blood collection holder. Also provided herein is a system that includes a diagnostic instrument, which includes a pump, an ecl detector, an incubator, a magnet, and an output device, and a cartridge configured to fit within a portion of the diagnostic instrument, a sample holder configured to fit within the cartridge, and a closed fluidic loop between the diagnostic instrument and the cartridge when the cartridge is fit within a portion of the diagnostic instrument, wherein the cartridge is configured to accept a sample from the sample holder and place the sample in fluidic communication with the diagnostic instrument via the closed fluidic loop..
05/14/15
20150132860

Clinical diagnostic system including instrument and cartridge


In embodiments disclosed herein, a diagnostic system is provided having a cartridge comprising at least one needle; at least one reservoir; at least one fluidic seal; and at least one fluidic channel of a fluidic pathway, wherein the cartridge is configured to store at least one reagent and at least one waste material on the cartridge. The diagnostic system is provided also having a diagnostic instrument comprising the fluidic pathway; an electrochemiluminescence (ecl) detection system; and a pump, wherein the fluidic pathway begins and ends in the cartridge and has a substantially single direction of flow in a pathway fluidically connecting the diagnostic instrument and the cartridge..
05/14/15
20150132859

Vibrio cholerae lipoprotein 15 (lp15) variants as anti-interference additive in tpn17-based immunoassays for detection of anti-treponema antibodies


The invention relates to a method for detecting antibodies against the tpn17 antigen of treponema pallidum in an isolated sample wherein a peptide sequence of vibrio cholerae lipoprotein 15 (vclp15) or a partial sequence thereof is used as a reagent for reduction of interference, i.e. For minimizing false positive results.
05/14/15
20150132786

Method for measuring glycosylated hemoglobin, measurement reagent, and measurement kit


Described is a method for accurately and highly sensitively measuring glycated hemoglobin in a hemoglobin-containing sample without being influenced by hemoglobin. It is related to a method for measuring glycated hemoglobin in a hemoglobin-containing sample, comprising: reacting hemoglobin-containing sample with a protease in the presence of a surfactant; and then reacting the obtained reaction product with fructosyl peptide oxidase, wherein the latter reaction or both of the former reaction and the latter reaction are performed in the presence of a halogen oxide, and measuring the generated hydrogen peroxide.
05/14/15
20150132785

Protease assay


The present invention provides a diagnostic reagent or assay for assessing the activity of a protease in vivo or in vitro and methods of detecting the presence of a cancerous or precancerous cell. The assays are comprised of two particles linked via an oligopeptide linkage that comprises a consensus sequence specific for the target protease.
05/14/15
20150132780

Melittin peptide conjugates and methods employing same


Methods and reagents are disclosed for conducting assays for ige specific for honey bee venom allergen. A reagent comprises a conjugate of a small molecule linked to a terminal glycine amino acid of a synthetic 26 amino acid melittin peptide.
05/14/15
20150132743

Proximity assays for detecting nucleic acids and proteins in a single cell


Methods and reagents for detection and analysis of nucleic acids and proteins using proximity extension assays.. .
05/14/15
20150132230

Protease assay


The present invention provides a diagnostic reagent or assay for assessing the activity of a protease in vivo or in vitro and methods of detecting the presence of a cancerous or precancerous cell. The assays are comprised of two particles linked via an oligopeptide linkage that comprises a consensus sequence specific for the target protease.
05/14/15
20150132211

Nano-porous carbons using sol-gel methods


The present patent application discloses a novel sol-gel process to synthesize a nano-porous solid carbon material—suitable for use in electrodes in energy storage applications—from a combination of liquid reagents that undergo a polymerization reaction to form a matrix. Also disclosed are novel nano-porous solid carbon materials.
05/14/15
20150130628

Nfc or rfid based bio sensor measurement device and measuring method using the same


Disclosed herein are an nfc or rfid based bio sensor measurement device and a measuring method using the same capable of measuring components by being linked with a wireless communication device such as a smart phone. According to an exemplary embodiment of the present invention, the nfc or rfid based bio sensor measurement device is configured to include: a bio sensor unit 100 embedded with a reaction reagent; and an nfc or rfid unit 200 which is electrically connected to the bio sensor unit 100 and wirelessly receives power from the external electronic devices and measures a measurement target value using the bio sensor unit 100 and wirelessly transmits the measured value to the external electronic devices..
05/14/15
20150130463

Portable device for nmr based analysis of rheological changes in liquid samples


The invention features a portable device for monitoring changes in the rheological state of multiple samples by nmr based measurement. The rheological changes can be, for example, gelation occurring during limulus amoebocyte lysate (lal) testing for endotoxins or blood coagulation.
05/14/15
20150129813

Irradiation-assisted production of nanostructures


Methods of producing nanowires and resulting nanowires are described. In one implementation, a method of producing nanowires includes irradiating (i) a metal-containing reagent; (ii) a templating agent; (iii) a reducing agent; and (iv) a seed-promoting agent (spa) in a reaction medium and under a condition of an elevated pressure above atmospheric pressure to produce nanowires..
05/14/15
20150129543

Method for etching metal or metal oxide by ozone water, smoothing surface of metal or metal oxide by ozone water, and patterning method using ozone water


Provided are a method for etching a metal or metal oxide without using a reagent, etc., that affects the environment, a method for smoothing a surface of a metal or metal oxide on an atomic level, and a method for patterning on an atomic level. Etching of a metal or metal oxide, or smoothing of a surface of a metal or metal oxide is possible using ozone water in which only ozone is dissolved.
05/14/15
20150129434

Measuring apparatus and measuring method


An apparatus and a method that can detect a defective analytical device due to the scattering of a reagent are provided. In particular, a blood glucose level meter (measuring apparatus) 1 is configured to measure a target component of a biological sample using a reagent.
05/07/15
20150126687

Chemical modification of lignin and lignin derivatives


A method for producing a trans-esterified hydroxypropyl lignin (hpl) is provided in one example embodiment and includes precipitating a lignin, dissolving the precipitated lignin in a solution, adding a reagent to the solution, adjusting the ph of the solution, allowing reactions in the solution to occur for a predetermined amount of time, precipitating the solution to produce a precipitate, and washing, filtering, and drying the precipitate to produce the trans-esterified hpl. In one example, a thermoplastic may be added to produce a trans-esterified hpl/thermoplastic blend..
Cyclewood Solutions, Inc.
05/07/15
20150126686

Chemical modification of lignin and lignin derivatives


A method for producing a trans-esterified hydroxypropyl lignin (hpl) is provided in one example embodiment and includes precipitating a lignin, dissolving the precipitated lignin in a solution, adding a reagent to the solution, adjusting the ph of the solution, allowing reactions in the solution to occur for a predetermined amount of time, precipitating the solution to produce a precipitate, and washing, filtering, and drying the precipitate to produce the trans-esterified hpl. In one example, a thermoplastic may be added to produce a trans-esterified hpl/thermoplastic blend..
Cyclewood Solutions, Inc.
05/07/15
20150126685

Chemical modification of lignin and lignin derivatives


A method for producing a trans-esterified hydroxypropyl lignin (hpl) is provided in one example embodiment and includes precipitating a lignin, dissolving the precipitated lignin in a solution, adding a reagent to the solution, adjusting the ph of the solution, allowing reactions in the solution to occur for a predetermined amount of time, precipitating the solution to produce a precipitate, and washing, filtering, and drying the precipitate to produce the trans-esterified hpl. In one example, a thermoplastic may be added to produce a trans-esterified hpl/thermoplastic blend..
Cyclewood Solutions, Inc.
05/07/15
20150126408

Anti-antibody reagent


An anti-antibody reagent for use in a competitive or sandwich simplex or multiplex assay, said reagent comprising one or more labeled anti-antibodies for the primary antibodies to be determined in the assay, the reagent further comprising a corresponding unlabeled anti-antibody in an excess or near excess concentration with respect to their binding partners.. .
Bio-rad Laboratories, Inc.
05/07/15
20150126406

Method for highly multiplexed quantitation of peptides by mass spectrometry and labeling reagent sets therefor


Disclosed herein are isobaric labeling reagent sets useful for multiplexed quantitation of peptides. The isobaric labeling reagent sets include a collection of at least two isobaric labeling reagents having first and second reporter groups with the same nominal mass but different isotopic substitutions and consequently different exact masses.
Thermo Finnigan Llc
05/07/15
20150126397

Detection of digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer by gene expression profiling


The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing genes with expression levels (in peripheral blood) that vary in association with digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer cases, compared with normal healthy subjects. Specifically, the method for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects.
National University Corporation Kanazawa University
05/07/15
20150126375

Assembly and analyzing nucleic acid sequences


An assembly and a method are disclosed for analyzing nucleic acid sequences by way of so-called sequencing-by-synthesis. According to an embodiment of the invention, a chemical substance group that is released when a nucleotide bonds to a nucleic acid sequence to be sequenced is detected.
Siemens Aktiengesellschaft
05/07/15
20150126031

Article and process for selective deposition


A process for depositing a metal includes disposing an activating catalyst on a substrate; contacting the activating catalyst with a metal cation from a vapor deposition composition; contacting the substrate with a reducing anion from the vapor deposition composition; performing an oxidation-reduction reaction between the metal cation and the reducing anion in a presence of the activating catalyst; and forming a metal from the metal cation to deposit the metal on the substrate. A system for depositing a metal includes an activating catalyst to deposit on a substrate; and a primary reagent to form: a metal cation to deposit on the substrate as a metal; and a reducing anion to provide electrons to the activating catalyst, the metal cation, the substrate, or a combination thereof, wherein the primary reagent forms the metal cation and the reducing anion in response to being subjected to a dissociating condition.
National Institute Of Standards And Technology
05/07/15
20150125939

Reagent delivery system


A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) pretilled with the selected reagents..
The Secretary Of State For Defence
05/07/15
20150125895

Formulations and process for isolating viable microorganism from positive blood cultures


Various embodiments disclosed herein provide for reagents and methods for rapidly isolating viable microbial cells, including s. Pneumoniae, from positive blood culture samples.
Becton, Dickinson And Company
05/07/15
20150125882

Microfluidic devices, and methods of making and using the same


The present disclosure provides methods and systems for assaying a sample. A microfluidic device to perform an assay of a sample (e.g., biological sample) is described having a sample application site, a porous component and a flow channel.
Becton, Dickinson And Company
05/07/15
20150125875

Methods for isotopically labeling biomolecules using mammalian cell-free extracts


Methods for producing an isotope-labeled mammalian, including a human, biomolecule, such as polypeptides and proteins, in a cell-free protein synthesis system. A biomolecule standard is produced having at least one isotope different in abundance than that of the naturally occurring isotopes in the biomolecule.
Pierce Biotechnology, Inc.
05/07/15
20150125865

Methods and apparatuses for droplet mixing


Methods and systems are provided for merging a droplet with a volume of fluid in a microfluidic system. In particular, the methods of the invention use a microfluidic structure designed to merge a fluid with a droplet in order to dilute, add volume, or add selected reagents, biological materials, or synthetic materials to a droplet.
Gigagen, Inc.
05/07/15
20150125862

Isolation of rna-protein complexes using cross-linking reagents and oligonucleotides


Provided herein is a method of sample analysis. In certain embodiments, the method comprises: a) cross-linking protein of a cell using a first compound to produce a first cross-linked product comprising cross-linked protein, and rna; b) contacting the first cross-linked product and a second compound under conditions by which an oligonucleotide portion of the second compound hybridizes to the rna; c) activating a reaction the first and second compound, thereby covalently crosslinking the oligonucleotide to the cross-linked protein to produce a second cross-linked product; d) isolating the second cross-linked product using an affinity tag; and e) analyzing the isolated second cross-linked product.
Agilent Technologies, Inc.
05/07/15
20150125856

Assays for resistance to echinocandin-class drugs


Nucleic acid amplification assays for mutations to two short sections of the fungal gene fks1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs.
Merck & Co., Inc.
05/07/15
20150125854

Methods and compositions for performing analytical operations


Methods for performing analytical reactions and compositions for use in such methods, where the methods have reduced signal levels deriving from non-specific adsorption of detected reagents to other components of the analytical method, e.g., other reagents, solid phase components, vessels, etc.. .
Pacific Biosciences Of California, Inc.
05/07/15
20150125473

Novel process for preparation of antibody conjugates and novel antibody conjugates


The present invention concerns a process for the preparation of an antibody conjugate comprising the step of reacting an engineered antibody having a single inter-heavy chain disulfide bond with a conjugating reagent that forms a bridge between the two cysteine residues derived from the disulfide bond.. .
Polytherics Limited
05/07/15
20150125364

Reagent preparation assembly


A reagent preparation assembly includes a body and a reaction chamber adjacent the body, the reaction chamber includes a reagent therein, such as a lyophilized reagent. An access port extends into the reaction chamber, and the access port is configured to receive an instrument.
Biolyph, L.l.c.
05/07/15
20150122778

Electroless plating method using non-reducing agent


A conductive pattern is formed in a polymeric layer that has (a) a reactive polymer comprising pendant tertiary alkyl ester groups, (b) a compound that provides an acid upon exposure to radiation, and (c) a crosslinking agent. The polymeric layer is patternwise exposed to radiation to provide a polymeric layer comprising non-exposed regions and exposed regions comprising a polymer comprising carboxylic acid groups.
04/30/15
20150119580

Synthesis of boronic esters and boronic acids using grignard reagents


Boronic esters and boronic acids are synthesized at ambient temperature in an ethereal solvent by the reaction of grignard reagents with a boron-containing substrate. The boron-containing substrate may be a boronic ester such as pinacolborane, neopentylglycolborane, or a dialkylaminoborane compound such as diisopropylaminoborane.
The Regents Of The University Of California
04/30/15
20150119573

Method for synthesizing sapropterin dihydrochloride


Disclosed is a method for synthesizing sapropterin dihydrochloride. The present disclosure reduces a synthesis route of the sapropterin dihydrochloride, and resolves a racemate intermediate or an intermediate having a low antimer isomerism value by using a chiral resolving reagent, thereby obtaining an intermediate having a high antimer isomerism value.
Jilin Asymchem Laboratories Co. Ltd.
04/30/15
20150119403

Mutant ros expression in human cancer


The invention provides the identification of the presence of mutant ros protein in human cancer. In some embodiments, the mutant ros are fig-ros fusion proteins comprising part of the fig protein fused to the kinase domain of the ros kinase.
Cell Signaling Technology, Inc.
04/30/15
20150119298

Analysis engine and database for manipulating parameters for fluidic systems on a chip


A system for performing one or more microfluidic processes includes an integrated fluidic device comprising a plurality of well regions and a plurality of control valves and a workflow manager. The system also includes a transfer robot adapted to transfer the integrated fluidic device between a plurality of stations in response to a series of instructions from the workflow manager and a first station comprising a dispensing robot adapted to dispense at least one of a plurality of sample solutions and at least one of a plurality of reagents into the integrated fluidic device.
Fluidigm Corporation
04/30/15
20150118740

Self-contained cartridge and methods for integrated biochemical assay at the point-of-care


Provided is a sample processing cartridge. The sample processing cartridge can include a housing and a channel disposed in the housing.
The Johns Hopkins University
04/30/15
20150118706

Urine sample analyzer and urine sample analyzing method


Disclosed is a urine sample analyzer for analyzing particles contained in a urine sample and outputting analytical results. The analyzer includes a flow cell that accepts a measurement specimen, the measurement specimen comprising a urine sample mixed with a reagent, a light irradiation unit positioned to irradiate the flowing measurement specimen with light, a light detector that detects light from individual particles in the flowing measurement specimen, and a data processor that receives signal from the light detector, processes the signal to obtain parameter information corresponding to a length of a cell cluster, and classifies fungi in the measurement specimen into groups by using the parameter information..
Sysmex Corporation
04/30/15
20150118696

Liquid diagnostic assays utilizing marangoni flow


The present invention provides simple and inexpensive assays for the detection of virtually any analyte in any sample that is in liquid form or that can be solubilized. The assays utilize the fluid dynamics of drop evaporation whereby soluble materials, including analytes and particles binding thereto, are drawn to the center of the drop by marangoni flow and ultimately form a concentrated residual spot.
Vanderbilt University
04/30/15
20150118677

Sample preparation for flow cytometry


Described herein are methods and reagents for identifying and analyzing at least one microorganism (e.g. Bacteria) in a sample and reducing the background signal intensity obtained when analyzing the sample by flow cytometry.
Becton, Dickinson And Company
04/30/15
20150118155

Compositions and methods for diagnosing and monitoring hyperthyroidism in a feline


The present invention provides a method of diagnosing the existence or risk of hyperthyroidism in a feline comprising measuring the level of expression of one or more biomarkers selected from the group consisting of e.g., iyd, tg, slc5a5, nis, tpo, tshr, duox1, duox2 (thox), tgfb1, cstd, dcn and sepp1 and the expression products thereof, in a biological sample from the feline, wherein elevated expression of the one or more biomarkers in the sample relative to a control value for expression in a sample from a normal feline or feline population, or a baseline value from the feline, indicates the existence or risk of hyperthyroidism; a method of treating a feline so diagnosed; and compositions, reagents and kits for carrying out the specified methods.. .
Hill's Pet Nutrition, Inc.
04/30/15
20150118125

Reagent set and reagent container packing box


Disclosed is a reagent set, including a boxy body; an internal holding member arranged in the box body to form a container accommodating region in the box body; and a reagent container, arranged in the container accommodating region, and including a main body portion and a mouth portion formed on an upper surface of the main body portion.. .
Sysmex Corporation
04/30/15
20150118100

Film deposition using precursors containing amidoimine ligands


Methods are provided for deposition of films comprising manganese on surfaces using metal coordination complexes comprising an amidoimino-based ligand. Certain methods comprise exposing a substrate surface to a manganese precursor, and exposing the substrate surface to a co-reagent..
Applied Materials, Inc.
04/30/15
20150117955

System and applying covering material with an aerosolization system


A method for effective and efficient water or wastewater aerosolization and industry specific and regulatory agency approved adc, soil stabilization or penetrating solution dissemination over identified and specific areas that are to be addressed. The water or wastewater and industry or regulatory body specifically approved adc, soil stabilization or penetrating reagent solution(s) is directed to an “integrated mobile aerosolization system (imas)” or other system having a turbine and being integrated and mobile.
04/30/15
20150114642

Aggregating reagents and methods for making and using same


Methods including using fluid including an aggregating composition including heterocyclic aromatic amines, substituted heterocyclic aromatic amines, polyvinyl heterocyclic aromatic amines, co-polymers of vinyl heterocyclic aromatic amine and non amine polymerizable monomers (ethylenically unsaturated mononers and diene monomers), or mixtures or combinations thereof in the absence of phosphate esters or amine-phosphate reaction products during drilling or fracturing operations to alter self-aggregating properties and/or aggregation propensities of the particles, surfaces, and/or materials in or entrained in the fluid.. .
Clearwater International, Llc
04/30/15
20150114140

Method for adjusting position of aspirator and sample processing apparatus


Disclosed is a method for adjusting a position of an aspirator in a sample processing apparatus, the sample processing apparatus comprising the aspirator configured to aspirate a sample or a reagent from a container and a capacitance sensor connected to the aspirator to detect change in capacitance, the method comprising: moving the aspirator above a position adjustment part which is electrically conductive and which is disposed at a predetermined position; obtaining capacitance detected by the capacitance sensor while moving the aspirator; and setting reference position information indicating a reference position of the aspirator based on change in the obtained capacitance.. .
Sysmex Corporation


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