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Reagent patents



      
           
This page is updated frequently with new Reagent-related patent applications. Subscribe to the Reagent RSS feed to automatically get the update: related Reagent RSS feeds. RSS updates for this page: Reagent RSS RSS


Novel reagents for directed biomarker signal amplification

Date/App# patent app List of recent Reagent-related patents
07/24/14
20140206903
 Novelcrosslinking reagents, macromolecules, therapeutic conjugates, and synthetic methods thereof patent thumbnailnew patent Novelcrosslinking reagents, macromolecules, therapeutic conjugates, and synthetic methods thereof
The invention provides novel chemical entities based on sugar alcohols. These new chemical entities are biocompatible and biodegradable.
07/24/14
20140206884
 Process using grignard reagents patent thumbnailnew patent Process using grignard reagents
The present invention relates to a process using grignard reagents for providing thio-triazolo group-containing compounds.. .
07/24/14
20140206776
 Mrm/srm assay for death receptor 5 protein patent thumbnailnew patent Mrm/srm assay for death receptor 5 protein
Specific peptides, and derived ionization characteristics of those peptides from death receptor 5 (dr5) protein are provided that are particularly advantageous for quantifying the dr5 protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring/multiple reaction monitoring (srm/mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
07/24/14
20140206775
 Srm/mrm assay for the fatty acid synthase protein patent thumbnailnew patent Srm/mrm assay for the fatty acid synthase protein
Specific peptides, and derived ionization characteristics of the peptides, from the fatty acid synthase (fasn) protein are provided that are particularly advantageous for quantifying the fasn protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
07/24/14
20140206603
 Engineered polypeptide agents for targeted broad spectrum influenza neutralization patent thumbnailnew patent Engineered polypeptide agents for targeted broad spectrum influenza neutralization
The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (ha) polypeptides and/or ha receptors, and reagents and methods relating thereto.
07/24/14
20140206578
 Process for determining the concentration of nucleic acids patent thumbnailnew patent Process for determining the concentration of nucleic acids
A process is disclosed for determining the concentration of nucleic acids in a sample in a microfluidic device. In at least one embodiment, the method includes a) introducing the sample into a first chamber, b) carrying out a number of cycles of an amplification reaction to be carried out in cycles for amplifying nucleic acids, c) transferring a defined volume which is a fraction of the volume of the first chamber and which has amplified nucleic acids into a second chamber and replacing the transferred defined volume with fresh reagents for the amplification reaction, d) determining the concentration of the amplified nucleic acids in a second chamber equipped with an element to determine concentrations, and e) repeating steps b)-d) until a concentration of the amplified nucleic acids which is within a range is determined in the second chamber.
07/24/14
20140206574
 Methods and compositons for the treatment and diagnosis of cancer patent thumbnailnew patent Methods and compositons for the treatment and diagnosis of cancer
The invention relates to methods of detecting cancer in a sample obtained from a subject. The invention also provides kits and reagents for detecting cancer as well as therapeutics and methods of treating cancer..
07/24/14
20140206564
 Reagents for improving pcr accuracy patent thumbnailnew patent Reagents for improving pcr accuracy
Provided herein are reagents for improving pcr accuracy.. .
07/24/14
20140206557
 Novel reagents for directed biomarker signal amplification patent thumbnailnew patent Novel reagents for directed biomarker signal amplification
Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors.
07/24/14
20140206098
 Low volume assay device having increased sensitivity patent thumbnailnew patent Low volume assay device having increased sensitivity
An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample addition zone containing a reagent material; a detection zone in fluid communication with the reagent zone. The detection zone has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a capillary space between the projections capable of generating capillary flow parallel to the substrate surface.
07/24/14
20140206088
new patent Unitized reagent strip
The embodiments disclosed herein relate to unitized reagent strips for holding and transporting reagents and materials used in automated sample preparation and/or processing for biological and or chemical assays.. .
07/24/14
20140206073
new patent Microfluidic system for nucleic acid analysis
A microfluidic system for analyzing nucleic acid, the microfluidic system including a reagent supply device including a sample chamber into which a sample can be injected, one or more reagent chambers for containing one or more reagents for extracting nucleic acid from the sample, and a waste chamber in which the used reagent can be discarded; a binding-lysis chamber in which cells are captured from the sample and lysed to form a cell lysate containing nucleic acid; plurality of particles for cell binding disposed in the binding-lysis chamber; a plurality of rehydration chambers into which the cell lysate formed in the binding-lysis chamber can be distributed and mixed with a nucleic acid amplification reagent to form an amplification reaction mixture; a plurality of amplification chambers in which a nucleic acid amplification reaction is performed on the amplification reaction mixture introduced from the plurality of rehydration chambers; and a flow channel system including an outlet and a plurality of inlets connected to the reagent supply device and forming an integrated fluid flow between the binding-lysis chamber, the rehydration chambers, and the amplification chambers.. .
07/24/14
20140206024
new patent Stable nad/nadh derivatives
The present invention provides for stable nicotinamide adenine dinucleotide (nad/nadh) and nicotinamide adenine dinucleotide phosphate (nadp/nadph) derivatives of formula (i), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.. .
07/24/14
20140206010
new patent Methods and kits for detecting mastitis
Methods and kits for determining if one or more animals have mastitis and for monitoring animals and the quality of the milk they produce are disclosed. Kits and test assays disclosed are used to determine the quantity of proteasomes and proteins thereof, the activity of proteasome enzymes, the quantity of proteasome bound and regulating proteins, and the quantity of ubiquinated protein.
07/24/14
20140206002
new patent Methods of diagnosing breast cancer
The disclosed subject matter is based on the discovery that a mutation (a single nucleotide polymorphism or “snp”) in the gene encoding abraxas (also referred to as abra1, ccdc98 or fam175a), is associated with susceptibility to cancer, e.g., breast cancer. In particular, the disclosed subject matter is based on the identification of a heterozygous alteration in the abraxas gene that is associated with breast cancer and specifically correlated with familial cancer.
07/24/14
20140206001
new patent Methods and compositions for enrichment of nucleic acids in mixtures of highly homologous sequences
Provided are methods of enrichment and detection of target nucleic acids during target amplification in the presence of excess amounts of highly homologous sequences, said methods having substantial diagnostic utility (e.g., cancer diagnostics). Provided are amplification reaction mixtures having at least one cleavage-directing oligonucleotide, the respective binding sites of which, for the target and homologous sequences, include one or more nucleotide positions differing in sequence between the target homologous sequences.
07/24/14
20140205998
new patent Method for enhancing extraction efficiency of mirna from cells by the addition of triton x-100
The present invention relates to a method for improving detection efficiency of mirnas existing in cells in trace amounts by adding triton x-100. In accordance with the present invention, mirnas existing in a sample in trace amounts can be quantitatively analyzed in short time.
07/24/14
20140205997
new patent Fluidic connectors and microfluidic systems
Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels.
07/24/14
20140205843
new patent Use of hydrophobic epoxide resin system for encapsulation of a instrument transformer
Disclosed is the use of a curable composition for padding-free encapsulation of instrument transformers comprising (a) a cycloaliphatic epoxy resin, (b) a polyoxyalkylene diglycidylether (c) an oh-terminated polysiloxane, (d) a cyclic polysiloxane and (e) a non-ionic, fluoroaliphatic surface-active reagent, (f) a filler, (g) a hardener selected from anhydrides, (h) a curing accelerator selected from accelerators for anhydride curing of epoxy resins.. .
07/24/14
20140205503
new patent Frazil ice conjugate assay device and method
An improved apparatus and method for dispersion of a labeling conjugate in a diagnostic assay, the result being a one-step assay. By eliminating a conjugate pad as in conventional lateral diagnostic devices, and forming a frazil ice pellicle (fip), rehydration and flow are improved resulting in better reproducibility, improved sensitivity, and reduced costs of individual assay devices.
07/24/14
20140205052
new patent Chelate free chemical decontamination reagent for removal of the dense radioactive oxide layer on the metal surface and chemical decontamination method using the same
A chemical decontamination reagent containing a reducing agent, a reductive metal ion, and an inorganic acid is provided to remove a radioactive oxide layer on a metal surface. The reagent can dissolve the radioactive oxide layer on the metal surface effectively at a relatively low temperature and enables a simple process of contacting the reagent to the radioactive oxide, thus economically effective in terms of cost and time required for the process.
07/24/14
20140203206
new patent Preparation of metal nanowire decorated carbon allotropes
In the method of embodiments of the invention, the metal seeded carbon allotropes are reacted in solution forming zero valent metallic nanowires at the seeded sites. A polymeric passivating reagent, which selects for anisotropic growth is also used in the reaction to facilitate nanowire formation.
07/24/14
20140202883
new patent Apparatus and methods for performing electrochemical reactions
The invention is directed to apparatus and methods for delivering multiple reagents to, and monitoring, a plurality of analytical reactions carried out on a large-scale array of electronic sensors under minimal noise conditions. In one aspect, the invention provides method of improving signal-to-noise ratios of output signals from the electronic sensors sensing analytes or reaction byproducts by subtracting an average of output signals measured from neighboring sensors where analyte or reaction byproducts are absent.
07/17/14
20140200341
Method for the production of fluoromethyl esters of androstan-17 beta carboxylic acids
Described herein are processes for the preparation of monofluoromethylated organic biologically active compounds, starting from protected intermediates and/or reagents to obtain compounds such as fluticasone propionate and fluticasone furoate, in presence of decarboxylating reagents xef2 and brf3, or using fch2sh as a reagent.. .
07/17/14
20140200167
Functionally integrated device for multiplex genetic identification
A biochip for multiplex genetic identification is disclosed. An biochip for separating and detecting a plurality of dna fragments includes a set of inputs and chambers for receiving a sample matrix of genetic material and reagents needed to conduct a polymerase chain reaction amplification of the genetic material.
07/17/14
20140199772
Procedure and automatic apparatus for in vitro blood coagulation diagnostic tests
Apparatus and processes for automated diagnostic testing may include cuvette dispensing, test sample dispensing, reagent dispensing, incubation, photo-optical measuring, and a control in operative communication with the cuvette dispensing unit, the test sample dispenser, the reagent dispenser, the incubation unit, and the measuring unit. A cuvette removal location, a reagent removal location, a measuring location, and a collection receptacle may be situated along a first common circular arc having first geometric center.
07/17/14
20140199758
Bilirubin hematolfluorometer and reagent kit
A reagent kit for detecting bilirubin in a fluid sample. The reagent kit includes a body defining at least one fluid receiving well and an optical window positioned over each at least one fluid receiving well.
07/17/14
20140199749
Compositions and methods for cdna synthesis
The present invention relates to methods and compositions for preparing cdnas, and more particularly, compositions having trehalose for synthesizing a cdna molecule or molecules from an mrna template or population of mrna templates under conditions sufficient to increase the detection sensitivity and cdna yield and to simplify and improve the reliability of reverse transcription. The reagent mixture comprises a ready to use reagent solution, wherein the solution comprises: (a) trehalose in a concentration between about 5% and about 35%; and (b) a viral reverse transcriptase selected from the group consisting of amv rt, rsv rt, mmlv rt, hiv rt, eiav rt, rav2 rt, aslv rt, rnaseh (−) rt, superscript ii rt, and thermoscript rt, in a buffer suitable for use in a reverse transcription reaction, wherein the buffer further comprises a co-factor metal ion and nucleoside triphosphates..
07/17/14
20140199724
Method and culture medium for enhanced detection of mycobacterium
The present invention relates to an improved culture medium and method for the enhanced growth and detection of mycobacterium growth. The invention further relates to an improved mycobacterial reagent system or kit that can be used for the enhanced growth and detection of mycobacterium..
07/17/14
20140199717
Multiplex mrm assay for evaluation of cancer
The current disclosure provides specific peptides, and derived ionization characteristics of the peptides from the estrogen receptor (er), progesterone receptor (pr), and/or antigen ki67 (ki67) proteins that are particularly advantageous for quantifying the er, pr, and/or ki67 proteins directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring/multiple reaction monitoring (srm/mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
07/17/14
20140199699
Compositions and methods for rt-pcr
The present invention relates to methods and compositions having trehalose and dna polymerase for facilitating the rapid and efficient amplification of nucleic acid molecules and the detection and quantitation of rna molecules, and for increasing the detection sensitivity and reliability through generation of secure cdna molecules prior to gene-specific primer dependent amplification. The reagent mixture comprises a ready to use reagent solution, wherein the solution comprises: (a) trehalose in a concentration between about 5% and about 35%; (b) a viral reverse transcriptase; and (c) at least one dna polymerases, in a buffer suitable for use in a reverse transcription reaction, wherein the buffer comprises a co-factor metal ion and nucleoside triphosphates..
07/17/14
20140199585
Low symmetry molecules and phosphonium salts, methods of making and devices formed there from
Synthesis of molecules and salts is disclosed having low average symmetry and their use in many applications, including but not limited to: as electrolytes in electronic devices such as memory devices including static, permanent and dynamic random access memory, as electrolytes in energy storage devices such as batteries, electrochemical double layer capacitors (edlcs) or supercapacitors or ultracapacitors, electrolytic capacitors, as electrolytes in dye-sensitized solar cells (dsscs), as electrolytes in fuel cells, as a heat transfer medium, high temperature reaction and/or extraction media, among other applications. In particular, synthesis methods and processes to form molecules and salts having low average symmetry using mixed grignard reagents are disclosed..
07/17/14
20140199314
Methods and compositions for regulating iron homeostasis by modulation of bmp-6
Modulation of iron homeostasis by regulating bmp-6 activity is provided. Methods of using bmp-6 and bmp-6 protein-specific reagents, such as antibodies, for altering serum iron levels in humans are provided.
07/17/14
20140199290
Genetic polymorphisms associated with alzheimer's disease, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with alzheimer's disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
07/17/14
20140199268
Variants of hepatitis b virus with resistance to anti-viral nucleoside agents and applications thereof
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis b virus (hbv) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies.
07/17/14
20140199208
Closure device
The invention relates to a device (1) for closing an opening in a container lid, and to the use of said device (1) in a container lid that is provided for covering reagent vessel containers in automatic analysis apparatus. The closure device comprises a fastening element (2), a closure element (20), two levers (14), and a plurality of bearings (18, 16, 24)..
07/10/14
20140194622
Methods for the synthesis of polycyclic guanidine compounds
The present invention provides methods for the synthesis of polycyclic guanidine compounds. In certain embodiments, provided methods include the step of contacting a described reagent with a triamine compound to provide a polycyclic guanidine compound..
07/10/14
20140194610
Methods for the synthesis of functionalized nucleic acids
Described herein are methods for the synthesis of derivatives of thiosulfonate reagents. Said reagents have utility for the synthesis of phosphorothiotriesters from h-phosphonates in a stereospecific fashion..
07/10/14
20140194304
Process for ultra-sensitive quantification of target analytes in complex biological systems
Antibody-free processes are disclosed that provide accurate quantification of a wide variety of low-abundance target analytes in complex samples. The processes can employ high-pressure, high-resolution chromatographic separations for analyte enrichment.
07/10/14
20140193983
Apparatuses and methods for depositing sic/sicn films via cross-metathesis reactions with organometallic co-reactants
Disclosed herein are methods of forming sic/sicn film layers on surfaces of semiconductor substrates. The methods may include introducing a silicon-containing film-precursor and an organometallic ligand transfer reagent into a processing chamber, adsorbing the silicon-containing film-precursor, the organometallic ligand transfer reagent, or both onto a surface of a semiconductor substrate under conditions whereby either or both form an adsorption-limited layer, and reacting the silicon-containing film-precursor with the organometallic ligand transfer reagent, after either or both have formed the adsorption-limited layer.
07/10/14
20140193925
Biosensors
A chemiresistive biosensor for detecting an analyte can include a high specific surface area substrate conformally coated with a conductive polymer, and a binding reagent immobilized on the conductive polymer, wherein the binding reagent has a specific affinity for the analyte. The conductive polymer can be deposited on a substrate by ocvd..
07/10/14
20140193918
Automatic analyzer
An automatic analyzer adapted to enhance sample/reagent dispensing accuracy, regardless of a difference in sample/reagent dispensing height of a dispensing probe. When the amount of sample in a sample container is small, tip height “h1” of a sample dispensing probe positioned immediately after it has aspirated the sample decreases below tip height “h′” of the sample dispensing probe positioned immediately before it discharges the sample.
07/10/14
20140193894
Sensor and package
A fluid sensor comprises a formed plastic body and a reagent. The body has a top face with an integral first surface.
07/10/14
20140193893
Genetic test system
There is provided a genetic test system provided with a dispensing means for dispensing a sample and a reagent to a reaction vessel and a vessel conveyance means for conveying the reaction vessel. The system further includes a plurality of nucleic acid amplification detection units, each including a temperature control means for accommodating a plurality of reaction vessels and performing temperature control for each accommodated position of the reaction vessel, a temperature monitoring means for monitoring a value of temperature to be controlled of the reaction vessel, and a light emission measurement means for measuring light emission of reaction liquid in the reaction vessel.
07/10/14
20140193859
Temperature-dependent insertion of genetic material into genomic dna
The present invention provides improved methods and reagents for insertion of genetic material into genomic dna.. .
07/10/14
20140193815
Methods of using oligonucleotides comprising a molecular switch
This invention relates to oligonucleotides comprising a molecular switch which may exist in an “open” or “closed” position. The molecular switch portion of the probe is particularly sensitive to the identity of sequences complementary to the molecular switch.
07/10/14
20140193801
Schiff-base conjugate of n, n-dibutyl-p-phenylenediamine with pyridoxal 5'-phosphate for improved homocysteine assays using pyridoxal 5'-phosphate-dependent enzymes
A composition, method and kit for performing a two-reagent enzymatic homocysteine assay, wherein a single homocysteinase enzyme and a schiff-based conjugate of n,n-dibutyl-p-phenyldiamine (dbpda) with pyridoxal 5′-phosphate (plp) are used to measure total homocysteine in plasma or serum. The assay measures a chromophore reaction product of h2s and the dbpda released from the schiff-base conjugate in the presence of a fe+3 containing compound.
07/10/14
20140193800
Systems and methods for continuous flow pcr systems
A liquid handling system of a pcr system is instructed to obtain a matrix of samples and reagents for a pcr experiment. A fluid pumping system of the pcr system is instructed to maintain a continuous flow of a transport fluid through a plurality of micro-channels that allows the mixture of the samples and the reagents producing a plurality of mixed sample droplets.
07/10/14
20140193425
Treatment of cancer with alk1 antagonists
Methods for evaluating responsiveness of a subject having cancer to treatment with an activin receptor-like kinase 1 (alk1) antagonist are provided. Methods for selecting a subject for treatment with an alk1 antagonist based on the subject being identified as responsive to such treatment are also provided.
07/10/14
20140193311
Integrated high throughput system for the analysis of biomolecules
Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activated or activatable. The affinity reagents bound to the surface of the affinity microcolumn further comprise affinity receptors for the integration into high throughput analysis of biomolecules..
07/10/14
20140191109
Assay apparatuses, methods and reagants
Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format..
07/10/14
20140190471
Cellulose-solvent-based lignocellulose fractionation with modest reaction conditions and reagent cycling
Embodiments of the present invention overcome the well-known recalcitrance of lignocellulosic biomass in an economically viable manner. A process and system are provided for the efficient fractionation of lignocellulosic biomass into cellulose, hemicellulose sugars, lignin, and acetic acid.
07/03/14
20140189895
Technique for cleaving out part of poly(a) chain and/or 3'-terminal sequence of mrna to inhibit translation reaction
A method of inhibiting the translation reaction of a target gene, comprising cutting out a part of the poly(a) tail and/or 3′-terminal sequence of the target mrna is provided. Also provided are a kit for inhibiting the translation reaction of a target gene, comprising a reagent capable of cutting out a part of the poly(a) tail and/or 3′-terminal sequence of the target mrna; a cell in which the translation reaction of a target gene is inhibited by introduction thereinto of a reagent capable of cutting out a part of the poly(a) tail and/or 3′-terminal sequence of the target mrna; and a non-human organism in which the translation reaction of a target gene is inhibited by introduction thereinto of a reagent capable of cutting out a part of the poly(a) tail and/or 3′-terminal sequence of the target mrna..
07/03/14
20140187819
Method for preparation of aryl poly(oxalkyl) quaternary ammonium compound
A method for preparation of an aryl poly(oxalkyl) quaternary ammonium compound is provided, said method comprising steps of: 1) reacting a phenol with a dihalopolyalkylene ether under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) halide; 2) reacting said arylpoly(oxalkyl) halide with an amination reagent under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) amine; 3) reacting said arylpoly(oxalkyl) amine with an alkylation reagent, to obtain an aryl poly(oxalkyl) quaternary ammonium compound; wherein r1 is h or a c1 to c16 alkyl group, located in the ortho, meta or para position; n is an integer of 2 to 6; r2 is h or a c1 to c16 alkyl group; r3 is h or a c1 to c16 alkyl group; r4 is a c1 to c16 alkyl group; x1 is br or cl; x is cl, br, or i. The preparation method according to the present invention requires low temperature and low pressure, the reaction time is short, and an overall yield can reach 75%.
07/03/14
20140187788
Processes for the preparation of thietanamine
The present invention provides processes for the preparation of compounds of formula (i) including processes comprising a. Reacting a a compound comprising a thietane moiety in which the carbon atom at the 3 position of the thietane moiety is bonded to a nitrogen atom; wherein the nucleophile is selected the group consisting of: n3−, a sulfonamide having two hydrogen atoms bound to the nitrogen atom, a diimide having a hydrogen atom bound to the nitrogen atom or an anion thereof, nh2oh and nh3; and b.
07/03/14
20140187742
Methods for purifying pertussis toxin and peptides useful therefor
The present invention relates to reagents and methods for purifying pertussis toxin (pt).. .
07/03/14
20140187009
Uniform, damage free nitride etch
An integrated circuit may be formed by forming a sacrificial silicon nitride feature. At least a portion of the sacrificial silicon nitride feature may be removed by placing the integrated circuit in a two-step oxidized layer etch tool and removing a surface layer of oxidized silicon from the sacrificial silicon nitride feature using a two-step etch process.
07/03/14
20140186936
Dna chip with micro-channel for dna analysis
A dna chip with micro-channel for dna analysis of dna included in an analyte according to a pcr method is a dna chip with micro-channel for dna analysis in which is silicon (first layer) and plastic (second layer) are laminated, wherein the second layer is formed on a partial area of the first layer, and the second layer includes: a reagent; a liquid transporting system; and a sensor, and the first layer includes a pcr reactor provided on an area on which the second layer is not formed.. .
07/03/14
20140186934
Rapid diagnostic device, assay and multifunctional buffer
An improved rapid diagnostic device, assay and multifunctional buffer reagent are provided for the detection of a target analyte in a fluid test sample. The 2-step assay utilizes a dual component flow-through device comprising a test unit and a dried indicator reagent delivery unit capable of receiving the fluid sample and multifunctional buffer, respectively.
07/03/14
20140186880
Salmonella and/or e. coli enzyme test and/or liquid drop test for biological substances, on non-human samples
A test kit and test apparatus are provided for the detection of enzymes excreted by broken or ruptured bacteria cells in various environments, such as in the field, soil extracts, produce washing, slaughter houses, food preparation area's and other related or non-related areas where a quick test or rapid test is needed to obtain qualitative results. The method utilizes various components which allow for the collection of a sample from suspected contaminated areas.
07/03/14
20140186850
Reagents and methods for bispecific antibody-based binding of target molecules
The invention provides methods for delivery of payloads to targets in samples using non-sterically hindered complexes. The invention further provides reagents and kits for practicing the methods of the invention.
07/03/14
20140186846
Dna chip with micro-channel for dna analysis
Provided is a dna chip with micro-channel for dna analysis, which has a structure in which a silicon layer (chip a) and a plastic layer (chip b) are laminated, wherein the chip a includes at least two pcr reactors connected in series in a micro-channel, and a filter between the pcr reactors, the chip b includes a reagent, a liquid delivery mechanism and a sensor in a micro-channel, and the reagent, liquid delivery mechanism and sensor can be changed according to a kind of an analyte and an object to be detected.. .
07/03/14
20140186532
Array printing
The invention provides a method of printing, onto a substrate (12), an array (14) of spots of reagent compositions for use in a chemical and/or biochemical analysis. The method includes displacing an array of reagent composition containing capillary tubes (22) arranged alongside one another from an inoperative position to an operative position in which open ends of the capillary tubes (22) simultaneously impinge against a substrate and thereafter displacing the array of tubes (22) from the operative position back to the inoperative position.
07/03/14
20140186423
Transdermal patch having ultrasound transducer for administering thrombolytic reagents to patients having a protein misfolding disease
The present invention relates to a method and device for treating patients with a protein misfolding disease by chronically administering an effective dose of a thrombolytic reagent and/or a thrombolytic reagent regulator over an intermittent period of time. The thrombolytic reagents degrade the misfolded proteins that accumulate and that can become toxic in such patients.
07/03/14
20140186333
Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease and in particular vt and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
07/03/14
20140186265
Multifunctional bacteriophage for delivery of therapeutic agents and imaging reagents
This invention relates to modified bacteriophage useful for the delivery of macromolecular biopolymers and nanoparticles to target cells, e.g., disease cells, and their use in cell-selective identification and imaging, as well as the treatment and prevention of diseases and other medical conditions.. .
07/03/14
20140186218
Method and apparatus for automatic staining of tissue samples
The present invention concerns an apparatus for staining tissue samples, said apparatus including a reagent section or reagent containers; at least one staining section or tissue samples, a robotic head or robotic element that may move reagent to a predetermined tissue sample, said robotic element being moveable above the reagent and the staining sections, a control element that may manage a staining process, a 2-d optical sensor to detect two-dimensional image data of a relevant property and that can feed the captured image data to the control element. By providing the robotic element with a 2-d optical sensor, a common image processor may be provided having multiple functions.
07/03/14
20140186213
Test tape cassette and analytical test tape therefor
A test tape cassette is disclosed that includes a cassette housing and an analytical test tape. The test tape includes a plurality of analytical test elements, a spreading fabric for applying a body fluid, and an underlying reagent layer for detecting an analyte in the body fluid.
06/26/14
20140179941
Synthesis and surface functionalization of particles
Provided are methods of controlling the shape and surface chemistry of nanoparticles, particularly ferrite nanoparticles. Methods for preparing non-spherical ferrite nanoparticles, including nanocubes, nanobars, nanoplates, and nanoflowers, are described.
06/26/14
20140179917
Preparation of maytansinoid esters
Provided are efficient methods for direct coupling of a maytansinoid with a carboxylic acid to prepare a maytansinoid c-3 ester in high yield using a rare earth metal-based or trifluoromethanesulfonate-based lewis acid catalyst and a base together with a coupling reagent. Also provided are compositions used in such methods..
06/26/14
20140179909
Microfluidic device for nucleic acid extraction and fractionation
Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the extraction and fractionation of dna molecules, from whole or lysed samples, in a single flow-through device.. .
06/26/14
20140179875
Sulfurization reagents on solid supports
Described herein are novel solid-supported sulfurization reagents having the general structure: (i) wherein (p) is a polymer; x is a linker; r1 is an alkyl group, a cycloalkyl group, an aryl group, or a heterocycle; and r2 is an alkyl group, an aryl group, a methyleneacyloxy group having the formula —ch2—o—c(o)—r7, a methylene carbonate group having the formula —ch2—o—c(o)—or8, or a methylene carbamate group having the formula —ch2—o—c(o)—nr9r10, wherein r7 is a c1 to c20 hydrocarbon residue, r8 is any alkyl, cycloalkyl, aryl, or heteroaryl, and r9 and r10 are independently hydrogen, alkyl, cycloalkyl, aryl, or heteroaryl. Other embodiments include solid-supported sulfurization reagents having the structure of formula i, wherein (p) is a polystyrene-based solid support and x is an aromatic linker.
06/26/14
20140179808
Detection of ovarian carcinoma by assay for autoantibodies to multiple antigens
Assays and reagents for the detection of autoantibodies to detect ovarian carcinomas are provided.. .
06/26/14
20140179762
Methods and compositions reducing target gene expression using cocktails of sirnas or constructs expressing sirnas
The present invention concerns methods and compositions involving the production or generation of sirna mixtures or pools capable of triggering rna-mediated interference (rnai) in a cell. Compositions of the invention include kits that include reagents for producing or generating sirna pools.
06/26/14
20140179598
Somatostatin analogs with inhibitory activity to growth hormone release
Provided are therapeutic and diagnostic somatostatin analogs including radiotherapeutic and radiodiagnostic reagents, and methods of making and use thereof.. .
06/26/14
20140179566
Thermal cycling apparatus and method
A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom.
06/26/14
20140179558
Method for detecting pancreatic cancer
This invention relates to a method for detecting pancreatic cancer using novel tumor markers. Specifically, the invention provides a method for detecting pancreatic cancer comprising measuring the presence or an amount of a polypeptide having an reactivity of binding via an antigen-antibody reaction to an antibody against caprin-1 protein in a sample separated from a subject, and to a reagent or kit for detecting pancreatic cancer comprising a caprin-1 protein or a fragment thereof, an antibody against the same, or a polynucleotide encoding the same..
06/26/14
20140179548
Molecular prognostic signature for predicting breast cancer metastasis, and uses thereof
The present invention is based on the discovery of a unique 14-gene molecular prognostic signature that is useful for predicting breast cancer metastasis. In particular, the present invention relates to methods and reagents for detecting and profiling the expression levels of these genes, and methods of using the expression level information in predicting risk of breast cancer metastasis..
06/26/14
20140179542
Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
The present invention is directed to novel methods for rapidly and unambiguously identifying small organic molecule ligands for binding to biological target molecules. Small organic molecule ligands identified according to the methods of the present invention may find use, for example, as novel therapeutic drug lead compounds, enzyme inhibitors, labeling compounds, diagnostic reagents, affinity reagents for protein purification, and the like.
06/26/14
20140179016
Reagent for measuring degree of oxidative stress and method of measuring degree of oxidative stress
The present invention provides a reagent for measuring a degree of oxidative stress that includes a compound represented by the following general formula (i) or a salt thereof, and a method of measuring a degree of oxidative stress using the reagent for measuring a degree of oxidative stress. In the general formula (i), r1, r2, r3 and r4 each independently represent a hydrogen atom, an ethyl group, an isopropyl group, a hydroxyalkyl group that has 1 to 4 carbon atoms, or a phenyl group, and at least one of r1, r2, r3 or r4 represents an isopropyl group, a hydroxyalkyl group having 1 to 4 carbon atoms, or a phenyl group..
06/26/14
20140179011
Rapid fluorescence tagging of glycans and other biomolecules with enhanced ms signals
Reagents comprising ms active, fluorescent molecules with an activated functionality for reaction with amines useful in tagging biomolecules such as n-glycans and uses thereof are taught and described.. .


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