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Reagent patents



      

This page is updated frequently with new Reagent-related patent applications.




Date/App# patent app List of recent Reagent-related patents
06/23/16
20160178651 
 Blood sample determination method and blood sample analyzer patent thumbnailnew patent Blood sample determination method and blood sample analyzer
Disclosed is a blood sample determination method including: emitting light to a measurement specimen prepared by mixing a clotting time measuring reagent and a blood sample suspected to be derived from a subject having lupus anticoagulant or a coagulation factor inhibitor, to obtain optical information about an amount of light from the measurement specimen; obtaining at least one parameter regarding derivative of clot waveform, based on the obtained optical information; and determining, based on a value of the obtained parameter, whether the blood sample is suspected to be a sample derived from a subject having lupus anticoagulant or is suspected to be a sample derived from a subject having a coagulation factor inhibitor.. .

06/23/16
20160178639 
 Sampling devices and methods of use patent thumbnailnew patent Sampling devices and methods of use
Sample-collecting devices, articles and methods of use are disclosed. Premoistened sample-collecting devices comprise 1,2-propanediol as a humectant, which promotes the retention of a liquid solution on the sample-collecting device during storage.

06/23/16
20160178624 
 Device and method to perform multiplex assays and target enrichment patent thumbnailnew patent Device and method to perform multiplex assays and target enrichment
A device termed the mobilearray™ device and methods, which form the mobilearray™ system, are disclosed for performing multiplex assays, target enrichment or purification. The device and methods disclosed enable the performing of multiplex assays, target enrichment or purification in a simplified manner.

06/23/16
20160178623 
 Assay device having multiple reagent cells patent thumbnailnew patent Assay device having multiple reagent cells
An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone. The reagent zone includes at least two reagent cells containing a reagent material and arranged in the reagent zone such that each reagent cell experiences substantially the same flow conditions of sample from the sample zone.

06/23/16
20160178603 
 Composite material with failure detection properties patent thumbnailnew patent Composite material with failure detection properties
A multiple layer composite material having fluid breach detection features provides indication of a failure in a fluid barrier. The indication of breach of fluid is provided before failure of a final layer of the composite material.

06/23/16
20160178594 
 Analyzer  sensing a chemical characteristic of a fluid sample patent thumbnailnew patent Analyzer sensing a chemical characteristic of a fluid sample
An analyzer system for sensing a chemical characteristic of a fluid sample according to one embodiment includes a sample inlet configured to receive the sample via the sample inlet, a reagent inlet configured to receive a reagent via the reagent inlet, a reaction zone in fluid communication with the sample inlet and the reagent inlet and being configured to receive the sample from the sample inlet and the reagent from the reagent inlet for mixing the sample with the reagent; and a sensor zone in fluid communication with the reaction zone, wherein the sensor zone comprises a sensor configured to sense the chemical characteristic of the mixed sample and reagent, and further wherein the sensor zone is configured to allow automatic drainage of the mixed sample and reagent away from the sensor after the sensor has sensed the chemical characteristic of the mixed sample and reagent.. .

06/23/16
20160178592 
 Apparatus for measuring concentrations of dissolved constituents patent thumbnailnew patent Apparatus for measuring concentrations of dissolved constituents
Provided is a device for measuring the concentration of a dissolved component, whereby the concentration of a plurality of types of dissolved components in water can be measured easily and with good precision. A device for measuring the concentration of a dissolved component has: a cell assembly 3 in which a plurality of cells 1 are connected by a joint member 2 and integrated, and a measurement reagent is accommodated in each of the cells 1; and a measuring main body 5 having a measurement unit (light-emitting element 8 and light-receiving element 9) for measuring transmittance and absorbance, the cells 1 of the cell assembly 3 being inserted into the measurement unit.

06/23/16
20160178571 
 Compositions, kits, and devices for generating and accurately measuring different oxygen levels in calibration and/or quality control reagents and methods of production and use thereof patent thumbnailnew patent Compositions, kits, and devices for generating and accurately measuring different oxygen levels in calibration and/or quality control reagents and methods of production and use thereof
Compositions, kits, and devices that include calibration and/or quality control reagent(s) for monitoring the performance of blood gas, electrolyte, and/or metabolite instrumentation are disclosed. Different oxygen levels in the calibration and/or quality control reagent(s) can be generated using an oxygen scavenger.

06/23/16
20160178526 
 Optical sensor device for repetitive assays in biological fluids patent thumbnailnew patent Optical sensor device for repetitive assays in biological fluids
Annular shaped sensor devices are disclosed that comprise an axial array of wedge-shaped optical sensors having tips oriented inward, with analyte-reactive reagents resident on a portion of the tip surfaces. These annular optical sensor devices are cut out from sheets or continuous sheeting of flat optically transparent polymers, and are preferably coated with a cladding material on major surfaces, other than the tips, so as to function as optical light guides.

06/23/16
20160177399 
 A kit for the prognosis of colorectal cancer patent thumbnailnew patent A kit for the prognosis of colorectal cancer
A kit for the prognosis of colorectal cancer, which includes reagents related in detecting the expression level of any one or more genes of the following five genes: bst1, as shown in seq id no:1; mgst1, as shown in seq id no:2, 3, 4, 5, 6, 7, 8, 9 or 10; hp, as shown in seq id no:11 or 12; rcan3, as shown in seq id no:13, 14, 15, 16, 17, 18, 19, 20, 21 or 22; and sra1, as shown in seq id no:23 or 24. The reagents are used to detect the expression level of any one or more of the above five genes in the preparation of a kit for the prognosis of colorectal cancer.

06/23/16
20160177381 
new patent

Base-pair specific inter-strand locks for genetic and epigenetic detection


A versatile detection method is disclosed that utilizes a base-pair-specific inter-strand lock for genetic and epigenetic detection. Reagents, devices, etc., for implementing the method have also been discovered and/or developed.

06/23/16
20160177380 
new patent

Compositions for rna-chromatin interaction analysis and uses thereof


The invention described herein provides reagents (e.g., kits), compositions, and methods for carrying out an unbiased genome-wide strategy to identify the functional targets for all ncrnas.. .

06/23/16
20160177260 
new patent

Method for producing dopaminergic neurons


The present invention provides a method of more efficiently producing a high-quality dopaminergic neuron from neural progenitor cells, specifically, a production method of a dopaminergic neuron including a step of culturing neural progenitor cells in a medium containing (i) a camp analogue and (ii) a mek inhibitor. Moreover, the present invention also provides a medicament containing a dopaminergic neuron obtained by the method, and a reagent and a kit to be used for the method..

06/23/16
20160176901 
new patent

Reagents and methods for fluorinating a substrate


Described herein are perfluoroalkylated zinc compounds having the structure of formula (i) or formula (ii), which can be used to perfluoroalkylate organic, inorganic and organometallic substrates. Methods of making and using these compounds by reacting zinc or a dialkylzinc compound with a perfluoroalkyl dihalide in a solvent such as tetrahydrofuran, dioxane or diglyme, are also described..

06/23/16
20160175841 
new patent

Mixing container used for reagents


A mixing container includes a first container that stores two or more reagents and a second container for mixing two or more reagents. The first container includes reagent storage chambers that are respectively provided for the two or more reagents and have openings formed at portions thereof, and a sealing member that seals the respective openings of the reagent storage chambers.

06/23/16
20160175066 
new patent

System for decontaminating medical equipment items and tracking decontamination process


A decontamination system (2) suitable for cleaning and disinfecting a medical instrument (26) such as an endoscope, the system comprising: (i) a plurality of pre-clean wipes for wiping an instrument to be decontaminated each pre-clean wipe comprising a moist fabric member in its own sealed container (4); (ii) a two-part disinfectant system comprising: (a) a first part comprising a first reagent in a carrier medium; and (b) a second part which is miscible with the first part and which comprises a second reagent in a carrier medium; wherein the first reagent and the second reagent will react when mixed to provide a disinfecting composition; the first part being contained in a dispenser (6) whereby it will be dispensed as a fluid when the dispenser is actuated, and the second part being absorbed or impregnated in a plurality of disinfecting wipes (30) each of which comprises a fabric member (30) in its own sealed container (8); and (iii) a plurality of rinse wipes, each rinse wipe comprising a moist, sterile, fabric member in its own sealed container (10); characterised in that each pre-clean wipe container (4) is provided with a machine-readable pre-clean wipe data carrier (36) which includes data specific to the pre-clean wipe; the dispenser (6) is provided with a machine-readable dispenser data carrier (58) which includes data specific to the first part; each disinfecting wipe container (8) is provided with a machine-readable disinfecting wipe data carrier (44) which includes data specific to the disinfecting wipe (30); and each rinse wipe container (10) is provided with a machine-readable rinse wipe data carrier (50) which includes data specific to the rinse wipe.. .

06/23/16
20160174566 
new patent

Methods, formulations, and kits for bacterial degradation


Methodologies, formulations, and kits suitable for decontaminating environments containing bacterial spores by degrading the spores. Formulations contain papain, at least one germinant, and optionally one or more additional enzymes.

06/16/16
20160172164 

Remote delivery of chemical reagents


Fluid storage and dispensing systems and methods for remote delivery of fluids are described, for providing fluid from a source vessel at lower voltage to one or more fluid-utilizing tools at higher voltage, so that the fluid crosses the associated voltage gap without arcing, discharge, premature ionization, or other anomalous behavior, and so that when multiple fluid-utilizing tools are supplied by the remote source vessel, fluid is efficiently supplied to each of the multiple tools at suitable pressure level during the independent operation of others of the multiple vessels.. .
Entegris, Inc.


06/16/16
20160171690 

Method and system for automated visual analysis of a dipstick using standard user equipment


A method for analyzing a dipstick using a smartphone is provided herein. The method includes: capturing an image containing: a dipstick having colored test reagents, and a color board having a grid of grey patches and a plurality of reference color patches; deriving, based on the grid, local illumination parameters associated with the colored test reagents and the plurality of reference color patches; determining whether illumination parameters are sufficient for interpreting the colored test reagent; in a case the illumination parameters are insufficient, notifying a user that an interpretation of the colored test reagents is not possible, otherwise, applying one or more image enhancement operation to the captured image, based on an analysis of the grid of grey patches, to yield enhanced reference color patches; and interpreting the one or more colored test reagents, by projecting the colored test reagents onto a vector of the enhanced reference color patches..
Ownhealth Ltd.


06/16/16
20160169910 

Non-glycosylated supar biomarkers and uses thereof


Proteinuria markers and methods for their use are provided. These markers find many uses, including in diagnosing proteinuria, prognosing proteinuria, and treating proteinuria.
Rush University Medical Center


06/16/16
20160169902 

Method for highly multiplexed quantitation of peptides by mass spectrometry and labeling reagent sets therefor


Disclosed herein are isobaric labeling reagent sets useful for multiplexed quantitation of peptides. The isobaric labeling reagent sets include a collection of at least two isobaric labeling reagents having first and second reporter groups with the same nominal mass but different isotopic substitutions and consequently different exact masses.
Thermo Finnigan Llc


06/16/16
20160169893 

Pcsk9 function assay


Methods and apparatuses for measuring the concentration of functional proprotein convertase subtilisin/kexin type 9 (pcsk9). A method of measuring functional pcsk9 in a sample is provided, by contacting the sample with a pcsk9-binding agent capable of binding to the ldl-r-binding region of a pcsk9; and measuring the amount of functional pcsk9 from the sample bound to the binding agent.
Atherotech, Inc.


06/16/16
20160169888 

Proteins expressed by mycobacterium tuberculosis and not by bcg and their use as diagnostic reagents and vaccines


The present invention is directed to reagents useful for generating immune responses to mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to m. Tuberculosis..
Rutgers, The State University Of New Jersey


06/16/16
20160169808 

Liquid and plate sensors for microplate injector system


In a sample analyzing apparatus, an injector assembly injects a reagent onto a sample, and luminescent light from the sample is transmitted to a detector. The assembly may be movable toward and away from the sample.
Molecular Devices, Llc


06/16/16
20160168645 

Gene expression profiles to predict breast cancer outcomes


Methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype.
British Columbia Cancer Agency Branch


06/16/16
20160168639 

Genetic polymorphisms associated with stroke, methods of detection and uses thereof


The present invention provides compositions and methods based on genetic polymorphisms that are associated with vascular diseases such as stroke. In particular, the present invention relates to genetic polymorphisms that have utility for such uses as predicting disease risk or predicting an individual's response to a treatment such as statins, including groups of polymorphisms that may be used as a signature marker set for such uses, as well as nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
Celera Corporation


06/16/16
20160168633 

Apparatus and methods for kinetic analysis and determination of nucleic acid sequences


A system for determining nucleic acid sequences, including (a) an array of nucleic acid features; (b) a fluidic apparatus configured to deliver sequencing reagents, including polymerases and nucleotides, to the array; (c) a detector configured to obtain pre-equilibrium kinetic measurements from the array at a resolution that distinguishes individual nucleic acid features; (d) a control module having instructions for (i) directing the fluidic apparatus to deliver the sequencing reagents to the array, and (ii) directing the detection apparatus to obtain the kinetic measurements; and (e) an analysis module having instructions for (i) processing the kinetic measurements to determine binding of the polymerase molecules to the nucleic acid features at several pre-equilibrium time points, thereby determining a transient state of the polymerase molecules at the nucleic acid features, and (ii) identifying nucleic acid features that correctly incorporate the nucleotide molecules based on the transient state of the polymerase molecules.. .
Illumina, Inc.


06/16/16
20160168613 

Device and methods of using device for detection of aminoacidopathies


The present invention relates to a biosensor capable of measuring the total concentration of one or a plurality of amino acids with the use of a reagentless system comprising an electrode modified by hydrogel that comprises at least one enzyme that oxidizes at least one substrate that is at least one amino acid. In some embodiments, the biosensor comprises a hydrogel comprising alginate.
The United States Of America, As Represented By The Secretary, Department Of Health And Human


06/16/16
20160168590 

Methods of improving titer in transfection-based production systems using eukaryotic cells


The invention relates to methods of improving titer in transfection-based bioreactor culture production or transfection-based production systems using eukaryotic cells. A method of improving viral titer in a transfectionbased production system using a eukaryotic cell is provided.
Children's Hospital Medical Center


06/16/16
20160168578 

Methods and devices for electromagnetic ligation of nucleic acids and electromagnetic transformation of cells


Described herein are methods and devices for ligating nucleic acids or nucleic acid fragments as well as methods for transforming or transfecting cells with exogenous dna. The methods and devices generally involve exposing the nucleic acids, nucleic acid fragments, and/or cells to an electromagnetic field, for example, a mini-current electromagnetic field, while performing the steps of ligation or transformation.
Internationl Park Of Creativity


06/16/16
20160168546 

Reconstituted histone methyltransferase complex and methods of identifying modulators thereof


The present invention provides a reconstituted complex including eed, ezh2 and suz12 wherein the reconstituted complex has histone methyltransferase (hmtase) activity for lysine 27 of histone h3 (h3-k27). The reconstituted complex may further include rbap48, aebp2 or both.
The University Of North Carolina At Chapel Hill


06/16/16
20160168525 

Cell culturing method, particulate culture carrier, and particle-encompassing cell aggregate


Provided is a culturing method capable of causing a three-dimensional aggregate in which cell function is similar to in vivo function to adhere to a culturing vessel while improving permeability of nutrients, oxygen, drugs and reagents from the culture medium and maintaining cell function. By sowing isolated cells in a culturing vessel, and after the cells have settled on the culturing surface, administering microscaffold particles that are cell-adhesive and substance-permeable onto the cells, it is possible to cause the cells to adhere to the culturing vessel while forming cell aggregates that encompass the particles.
Hitachi High-technologies Corporation


06/16/16
20160168274 

Cellulose particulate material


The invention relates to plant-derived cellulose-containing particles useful as strengthening agents in water based systems and to a process for preparing cellulose-containing particles from plant material, which process involves treating said plant material with a peroxide reagent. The process can be controlled to produce cellulose-containing particle having a viscosity up to about 2500 cps..
Cellucomp Limited


06/16/16
20160168273 

Cellulose particulate material


The invention relates to plant-derived cellulose-containing particles useful as rheology modifiers and to a process for preparing cellulose-containing particles from plant material, which process involves treating said plant material with a peroxide reagent. The process can be controlled to produce cellulose-containing particle having a viscosity up to about 7500 or 8000 cps..
Cellucomp Limited


06/16/16
20160168192 

Process for the preparation of abiraterone and abiraterone acetate


The present invention relates to a novel process for the synthesis of abiraterone, and in particular of abiraterone acetate, compound of formula (i) reported below: n o (i) which has pharmacological activity useful for slowing down the progression of prostate cancer at an advanced stage. The process is characterised by an intermediate step wherein dhea-acetate is triflated using ar-n(otf)2 as the triflation reagent..
Industriale Chimica S.r.l.


06/16/16
20160168191 

Process for the preparation of abiraterone or abiraterone acetate


The present invention relates to a novel process for the synthesis of abiraterone and in particular abiraterone acetate, a compound of formula (i) reported below: having pharmacological activity suitable for slowing down the progression of advanced stage prostate cancer. The process is characterised by the fact that the intermediate triflation step is carried out on prasterone (dhea) or its 3-acetate using ar—n(otf)2 as the triflation reagent, but where ar is not phenyl, and by the fact that the base used in this step is an alkali metal alcoholate..
Industriale Chimica S.r.l.


06/16/16
20160168187 

A the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides


Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during dna polymerase-mediated replication of dna or rna polymerase-mediated transcription of rna. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded dna or rna), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo-bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker..
Synthorx, Inc.


06/16/16
20160167998 

Method for the treatment of water comprising a step of adsorption on ion-exchanging resin and a step of ballasted coagulation/flocculation and of separation, and corresponding plant


Method for treating water, containing organic matter characterized in that it comprises a step of adsorption of the organic matter contained in said water, in which this water is put into contact with an amagnetic ion-exchanging resin in an infinitely stirred tank (1); the filtering of the mixture of water and resin within the tank (1) and the discharging of filtered water from this tank, the filtering being implemented through at least one screen (4) provided within the tank (1) enabling the resin to be contained in the infinitely stirred tank; the periodic cleansing of the screen (4) consisting of the separation, from this screen, of the saturated resin that has collected thereon; the drawing off (18) of saturated resin from the tank (1); the regenerating (6) of at least a part of the saturated resin thus drawn off; the recycling (7) of said resin thus regenerated in the tank (1); a step of ballasted coagulation/flocculation (12, 13) and separation (14) comprising the addition of coagulant reagent (12b), flocculent reagent (13b) and microballast (21) to the filtered water coming from the tank (1) leading to the formation of flocs; the separation of the formed flocs from a clarified water (16); and the discharging (16) of the clarified water; and the discharging (17) of the sludges formed by the separated flocs.. .
Veolia Water Solutions & Technologies Support


06/16/16
20160166974 

An gas cleaning


The invention proposes an apparatus for gas cleaning having a high gas cleaning efficiency at any relative humidity. The apparatus comprises a passage (10) for gas flow; a hydrophilic carrier (12) permeable for gas flow, at least part of which is positioned within said passage for gas flow, and configured for containing a reagent that contacts the gas in said passage for gas flow; a unit (14) for disposing liquid to said carrier; and a controller (16), associated with said unit for disposing liquid, configured for controlling the unit for disposing to dispose an aqueous solution of dissolved reagent to the carrier; and after that controlling the unit for disposing to dispose liquid in case the humidity of the gas is below a first humidity threshold, or to stop disposing liquid in case the humidity of the gas is above a second humidity threshold..
Koninklijke Philips N.v.


06/16/16
20160166868 

Plasma abatement using water vapor in conjunction with hydrogen or hydrogen containing gases


A plasma abatement process for abating effluent containing a pfc gas from a processing chamber is described. A plasma abatement process takes gaseous foreline effluent from a processing chamber, such as an etch chamber, and reacts with the effluent within a plasma chamber placed in the foreline path.
Applied Materials, Inc.


06/09/16
20160161521 

Automatic analyzer


An automatic analyzer provided with a roller and a reagent container shoulder presser at the position where an operator inserts a reagent container into the automatic analyzer. The reagent container is pushed while the lid of the reagent container is made to touch the upper side of the roller and the shoulder presser is made to touch the shoulder of the reagent container, and the application of upward force to the lid causes the lid of the reagent container to be half open, after which the reagent container is inserted in the analyzer..
Roche Diagnostics Operations, Inc.


06/09/16
20160161518 

Temporary store


An analyzer for detecting or quantitating an analyte comprising a temporary storage unit for storing a reagent cassette and a method for presenting a reagent cassette present in a temporary storage unit to a pipetting device are described.. .
Roche Molecular Systems, Inc.


06/09/16
20160161516 

Systems and methods for managing inventories of reagents


A system for managing the inventory of reagents for a laboratory automation system. The system for managing the inventory of reagents comprises a controller, software for the controller, and a refrigerator capable of refrigerating reagents, detecting the presence or absence of reagents in the refrigerator, and detecting the location of reagents in the refrigerator.
Abbott Laboratories


06/09/16
20160161512 

Method and reagent for quantifying cholesterol in high density lipoprotein 3


Disclosed are a method and a reagent for quantifying hdl3 in a test sample without requiring laborious operations. The method for quantifying cholesterol in high-density lipoprotein 3 comprises reacting a test sample with one or more surfactants which react specifically with high-density lipoprotein 3, and quantifying cholesterol.
Denka Seiken Co., Ltd.


06/09/16
20160161490 

Reagent for measuring endotoxin and measuring endotoxin


Provided is a method for measuring endotoxin in which glucose-1-phosphate or glucose-6-phosphate is added to a sample and a detection reagent is added to the sample. Furthermore, a reagent for measurement according to the present invention contains glucose-1-phosphate or glucose-6-phosphate.
Sawai Pharmaceutical Co., Ltd.


06/09/16
20160161480 

Method for the detection of the prozone effect of photometric assays


A method for determination of the amount of a specific analyte in a sample which may show a prozone effect by photometric assays, wherein the specific analyte is quantified from the change in the optical signal of the reaction mixture after the interaction of the analyte with analyte specific assay reagents. The optical signal is measured simultaneously for the specific analyte in the sample to be determined at the wavelength used for the determination of the analyte and at least at an additional specific wavelength used for the detection of the prozone effect over the complete reaction time.
Roche Diagnostics Operations, Inc.


06/09/16
20160161416 

Method of accurate thickness measurement of boron carbide coating on copper foil


A method is disclosed of measuring the thickness of a thin coating on a substrate comprising dissolving the coating and substrate in a reagent and using the post-dissolution concentration of the coating in the reagent to calculate an effective thickness of the coating. The preferred method includes measuring non-conducting films on flexible and rough substrates, but other kinds of thin films can be measure by matching a reliable film-substrate dissolution technique.
Proportional Technologies, Inc.


06/09/16
20160160611 

Method and apparatus to deliver a reagent to a downhole device


In one aspect, a downhole device for use in a downhole environment is disclosed, including: a first material with a first degradation rate in the downhole environment and at least one cavity, wherein the at least one cavity contains a second material to degrade the first material at a second degradation rate when the second material is exposed to the downhole environment and the first material, the second degradation rate being higher than the first degradation rate. In certain embodiments, the second material is a solid second material.
Baker Hughes Incorporated


06/09/16
20160160297 

Methods and compositions for detecting mutations in the human pi3kca (pik3ca) gene


The invention comprises reagents and methods for detecting cancer-associated mutations in the human pi3kca (pik3ca) gene and assessing the patients based thereon.. .
Roche Molecular Systems, Inc.


06/09/16
20160160259 

Automated detection of assay-positive areas in microfluidic devices


Methods are provided for the automated detection of assay-positive assay areas in a microfluidic device. When assays are performed in a microfluidic device, the configuration of the microfluidic circuit and its constituent circuit elements can determine where the reagents/analytes used in the assay can be located within the microfluidic circuit.
Berkeley Lights, Inc.


06/09/16
20160160209 

Sequential delivery device and method


A reagent delivery method includes placing a reagent delivery column including a plurality of reagent storage elements therein in a centrifugal device, coupling a breaching element to the housing, and rotating the centrifugal device to force the reagent storage elements toward the breaching element, breaching of the reagent storage elements releasing reagent therein and communicating the same to an external environment. A reagent delivery system includes a column having a housing, a plurality of reagent storage element sheets positioned in the housing or forming a stack, a plurality of breaching elements, and a microplate having a plurality of wells, the microplate coupled to the housing where each well corresponds or aligns with a breaching element and a reagent storage element.

06/09/16
20160160162 

Injectable tissue engineered cartilage in vitro construction apparatus


An injectable tissue engineered cartilage in vitro construction apparatus, comprising an incubator (1), a centrifugal device arranged in the incubator (1), and a control system for controlling a temperature in the incubator (1) and an action of the centrifugal device. The centrifugal device comprises a centrifuge, a container base (2) mounted onto the centrifuge, a dosing system for adding preparation reagent, and a stirring system for stirring the reagent.
First Affiliated Hospital, Third Military Medical University, Chinese People's Liberation Army, P.r.


06/09/16
20160160048 

Polymers and plastics derived from animal proteins


The invention is directed to a method for preparing a polymer derived from an animal protein, such as in a feedstock derived from animal by-products. The method involves hydrolyzing proteins present in a feedstock to obtain hydrolyzed proteins, wherein hydrolysis is conducted under conditions sufficient to digest the proteins and destroy pathogens; extracting a protein fraction from the hydrolyzed proteins; and treating the protein fraction with a crosslinking reagent to form the polymer.
The Governors Of The University Of Alberta


06/09/16
20160160046 

Crystalline latex production


A process for making a crystalline latex suitable for use in a toner by phase inversion emulsification (pie) where the liquid reagents, such as, organic solvent(s), neutralizing agent and water, are reused from a prior pie.. .
Xerox Corporation


06/09/16
20160159953 

Reagent for enhancing generation of chemical species


A reagent that enhances acid generation of a photoacid generator and composition containing such reagent is disclosed.. .
Toyo Gosei Co., Ltd.


06/09/16
20160159904 

Cancer stem cell-specific molecule


An objective of the present invention is to obtain two types of substantively homogeneous cancer stem cell populations which can be characterized using the cell surface marker lgr5, and to provide cancer therapeutics using an antibody against a cell membrane molecule specifically expressed in these cancer stem cells by identifying said cell membrane molecule. A further objective is to provide, using an antibody against a cell membrane molecule specifically expressed in cancer stem cells, a reagent for detecting cancer stem cells, and a method for diagnosing and sorting cancer patients.
Chugai Seiyaku Kabushiki Kaisha


06/09/16
20160159777 

Crosslinking reagents, methods, and compositions for studying protein-protein interactions


The invention provides reagents, methods, and compositions for studying protein-protein interactions. The inventive system and methods allow the analysis of protein-protein interactions in vivo and in vitro.
Cellmosaic, Inc.


06/09/16
20160159747 

Method for preparation of benzimidazole derivatives


The present invention provides a method for preparing a compound with a benzimidazole structure with an excellent yield using a low-cost starting material, not requiring an additional separation process, or not using a dangerous reagent during the manufacturing process. Furthermore, the present invention also provides an intermediate and a final product produced by the preparing method..
Cj Healthcare Corporation


06/09/16
20160158757 

Actuated microfluidic structures for directed flow in a microfluidic device and methods of use thereof


A microfluidic device can comprise a plurality of interconnected microfluidic elements. A plurality of actuators can be positioned abutting, immediately adjacent to, and/or attached to deformable surfaces of the microfluidic elements.
Berkeley Lights, Inc.


06/09/16
20160158750 

Microfluidic devices and methods of manufacture and use


Microfluidic devices are provided for conducting fluid assays, for example biological assays, that have the ability to move fluids through multiple channels and pathways in a compact, efficient, and low cost manner. Discrete flow detection elements, preferably extremely short hollow flow elements, with length preferably less than 700 micron, preferably less than 500 micron, and internal diameter preferably of between about 50+/−25 micron, are provided with capture agent, and are inserted into microfluidic channels by tweezer or vacuum pick-and-place motions at fixed positions in which they are efficiently exposed to fluids for conducting assays.
Cyvek, Inc.


06/02/16
20160155972 

Nanostructured organic memristor/memcapacitor of making with an embedded low-to-high frequency switch and a inducing an electromagnetic field thereto


An organic memresitor/memcapacitor comprises of two terminal electrodes, each electrode has a membrane made of nanostructure organic conducting polymer of cyclodextrin derivatives attached thereto. By self assembling of cross-linking copolymers forming conductive membranes and separated by a mobile dopant barrier dielectric material, one side of the membrane has structure formed flat horizontal nano-bridges with array larger vertical nanopores underneath the bridge; and another side of the electrode/membrane has a negative mobile dopant polymer network forming arrays nano-islands with the membrane thickness is one third of the opposite membrane to be feasible conducting “head-tail” biphase charge and discharge at wide range of frequencies, so called the low-to-high frequency switch embedded to effectively save energy and storage energy by utilizing functional groups mimicking the positive and negative isopotential poles active sites of the acetylcholinesterase (ache) gorge along strengthened by a hydrophobic reagent.

06/02/16
20160153987 

Mycobacterium antigens


There is provided a diagnostic reagent for use in the detection of m. Bovis or m.
The Secretary Of State For Environment, Food And Rural Affairs


06/02/16
20160153986 

Proteins expressed by mycobacterium tuberculosis and not by bcg and their use as diagnostic reagents and vaccines


The present invention is directed to reagents useful for generating immune responses to mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to m. Tuberculosis..
Rutgers, The State University Of New Jersey


06/02/16
20160153953 

Water testing


A method of testing water is described which comprises the steps of taking a sample to be tested, diluting the sample, applying a reagent to the sample, heating the sample for a predetermined period, and using the colour of the sample to provide an indication of the water quality.. .
University Of Plymouth


06/02/16
20160153911 

Instant view of protein bands


Apparatus, reagents, pre-treated proteins and methods for dying proteins in electrophoresis run gels, and for instantly viewing such dyed protein samples in an electrophoresis gel. A protein mixing solution containing a fluorescence dye is mixed with a protein sample so that fluorescence dyes within the protein mixing solution conjugate to proteins within the protein sample.

06/02/16
20160153274 

Fracturing fluid for subterranean formations


A method of fracturing a reservoir comprising the steps of pumping a geopolymer precursor fluid through a wellbore into the reservoir at a fracture pressure, the geopolymer precursor fluid at the fracture pressure generates fractures in the reservoir, wherein the geopolymer precursor fluid is comprised of an amount of aluminosilicate, an amount of alkaline reagent, and a permeability enhancer, allowing the geopolymer precursor fluid to fill the fractures in the reservoir, shutting-in the wellbore at a wellbore pressure, the wellbore pressure maintains the geopolymer precursor fluid in the fractures, allowing the geopolymer precursor fluid to harden for a hardening time to form a geopolymer in the fractures, the geopolymer has a geopolymer matrix, the geopolymer matrix has a permeability, the geopolymer has a compressive strength, and reducing the wellbore pressure allows a reservoir fluid to flow from the reservoir through the geopolymer matrix of the geopolymer to the wellbore.. .
Aramco Services Company


06/02/16
20160153066 

Process for efficiently enriching and recovering noble metals of platinum and palladium by solvent extraction


The present invention relates to a process for efficiently enriching and recovering noble metals of platinum and palladium based on solvent extraction, wherein isoamyl alcohol is used as extracting agent and 2-methoxyphenyl thiourea is used as extraction-assisted complexing agent. 2-methoxy-phenyl thiourea is added to aqueous phase to react with platinum and palladium, and isoamyl alcohol is used as extracting agent to extract the organic phase, thus realizing the purpose of separating and extracting noble metals from base metals while enriching noble metals of platinum and palladium.
Beijing University Of Technology


06/02/16
20160153051 

Gene expression profiles to predict breast cancer outcomes


Methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype.
British Columbia Cancer Agency Branch


06/02/16
20160152856 

Sorbic acid ester composition


The present invention is a method comprising the steps of a) applying a composition comprising a curing agent and a cure modulating additive to a substrate; and b) allowing the composition to cure. The curing agent is a sorbic acid ester or a sorbamide and the cure modulating agent is a reagent capable of modulating the rate of cure of the curing agent..
Dow Global Technologies Llc


06/02/16
20160152672 

Reagents and methods for treating dental disease


The present invention provides reagents and methods for treating dental disease.. .
University Of Washington Throught Its Center For Commercialization


06/02/16
20160152014 

Transparent conductive sheet and touch panel using transparent conductive sheet


Provided is a transparent conductive sheet in which a silver nanowire is resistant to oxidation even if the silver nanowire is exposed to visible light. The transparent conductive sheet includes a base sheet, a silver nanowire holding layer laminated on the base sheet, a sacrificial reagent added into the silver nanowire holding layer, and a silver nanowire laminated on a surface of the silver nanowire holding layer..
Nissha Printing Co., Ltd.


06/02/16
20160151783 

Analysis device and detecting module


An analysis device including a detecting module and a main module is provided. The detecting module includes a first body having an injection opening and a sample liquid, a first connector and a detecting chip disposed at the first body and electrically connected with each other.
Htc Corporation


06/02/16
20160151750 

Fluid mixing structure


A fluid mixing structure adapted to mix a reagent liquid and a sample liquid is provided. The fluid mixing structure includes a first channel, a mixing recess, a first block, a plurality of second blocks, and a second channel.
Htc Corporation


06/02/16
20160151301 

Compositions and methods for treating alzheimer`s disease and related disorders and promoting a healthy nervous system


The present invention relates generally to methods of inhibiting the onset and progression of alzheimer's disease (ad), mild cognitive impairment (mci), and related neurodegenerative disorders involving amyloidosis. The methods involve administering a composition comprising a therapeutically effective amount of d-pinitol to individuals who are at risk of developing the disease or have one or more symptoms of the disease.
Icahn School Of Medicine At Mount Sinai


05/26/16
20160147144 

Reagent for enhancing generation of chemical species


A reagent that enhances acid generation of a photoacid generator and composition containing such reagent is disclosed.. .
Toyo Gosei Co., Ltd.


05/26/16
20160146846 

Automatic analyzer


An automatic analysis device is provided with a reagent container disk, a reagent loader (6), a reagent loader position sensor, an rfid antenna, a memory unit, a reagent loading switch (26), and reagent load position leds (21-25). The reagent loader (6) has a plurality of slots for inserting reagent containers (4) and moves between the outside and the reagent container disk.
Hitachi High-technologies Corporation


05/26/16
20160146462 

Plant, combustion apparatus, and reduction of nox emissions


A combustion apparatus includes a combustion chamber having multiple combustion zones. A first wind box is in communication with the first combustion zone to feed the fuel to be fed into the combustion chamber for initial combustion of the fuel within the first combustion zone.
Alstom Technology Ltd


05/26/16
20160145677 

Spatially encoded biological assays using a microfluidic device


The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents, in particular, microfluidic device based instrumentation; and a decoding scheme providing a readout that is digital in nature..
Prognosys Biosciences, Inc.


05/26/16
20160145274 

Reagent for enhancing generation of chemical species


A reagent that enhances acid generation of a photoacid generator and composition containing such reagent is disclosed.. .
Toyo Gosei Co., Ltd.


05/26/16
20160145265 

Method and the synthesis of dihydroartemisinin and artemisinin derivatives


The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (dhaa) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one c1-c5 alcohol..
Max-planck-gesellschaft Zur FÖrderung Der Wissenschaften E.v.


05/26/16
20160145189 

Triesters from alpha-and-beta-hydroxyesters


A method of making a benzyl cis-cyclohexane 1,2-dicarboxylate triester having the steps: a. Forming a reaction mixture by reacting the following three components: i.
Valtris Specialty Chemicals


05/26/16
20160144364 

Reagent dispensers, dispensing apparatus, and methods


Disclosed is a reagent dispenser apparatus. The reagent dispenser apparatus has a reagent container having a dispense port operable to open and close to dispense reagent.
Siemens Healthcare Diagnostics Inc.


05/26/16
20160144357 

Apparatuses with pre-packaged reagents


Apparatuses with pre-packaged reagents comprise a reagent package and a protrusion member. More particularly, the reagent package comprises a base and a cover layer, in which the base further comprises at least one pocket.
Shaoxing Pushkang Biotechnology Co., Ltd


05/26/16
20160144331 

Method for generating an affinity reagent library


The present disclosure provides a method for generating an affinity reagent library against a target protein which interacts with a ligand, which comprises the following steps; i) determining one or more structural element(s) of the ligand which are involved in ligand: target protein interaction; ii) producing a library of peptides which retain these structural element(s); and iii) grafting each peptide from the library of peptides into a portion of the affinity reagent molecule such that it may interact with the target protein, in order to produce an affinity reagent library.. .
Queen Mary University Of London


05/26/16
20160144046 

Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method


Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction.
Nektar Therapeutics


05/26/16
20160144007 

Treatment of conditions related to shock


Techniques are disclosed for prevention or treatment of physiological shock by administering a specific therapeutic agent, which is able to use smaller volumes of reagent to achieve complete inhibition, than other previously described techniques.. .
The Regents Of The University Of California


05/26/16
20160143896 

Chiral 1-(4-methylphenylmethyl)-5-oxo--pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion


Chiral 1-(4-methylphenylmethyl)-5-oxo-{n-[(3-t-butoxycarbonyl-aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion. The present invention provides chiral (2s)-1-(4-methyl-phenylmethyl)-5-oxo-(3s)-{n-[(3-t-butoxycarbonyl aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide, and (2s)-1-(4-methylphenylmethyl)-5-oxo-(3r)-{n-[(3-t-butoxycarbonyl amino methyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide of formula 6 and 7 respectively.
Council Of Scientific & Industrial Research


05/19/16
20160139136 

Rapid fluorescence tagging of glycans and other biomolecules with enhanced ms signals


Reagents comprising ms active, fluorescent molecules with an activated functionality for reaction with amines useful in tagging biomolecules such as n-glycans and uses thereof are taught and described.. .
Waters Technologies Corporation


05/19/16
20160139134 

Method for analysis of compounds with amino group and analytical reagent therefor


The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-n-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity.
Ajinomoto Co., Inc.


05/19/16
20160139116 

In vitro capture and analysis of circulating tumor cells


This invention provides methods and compositions for capturing circulating tumor cells (ctcs) as well as various divergent ctc phenotypes using seprase-specific affinity reagents. Methods of analyzing ctcs and assessing their metastatic potential in vivo and in vitro are also disclosed..
The University Of North Carolina At Chapel Hill


05/19/16
20160139102 

Paper microfluidic devices for detection of improvised explosives


Paper microfluidic devices for testing for explosives are provided, along with methods of fabricating and using the same. One or more channels are formed on a paper substrate, and a test spot is formed in at least one of the channels.
The Florida International University Board Of Trustees


05/19/16
20160139072 

Biosensor and manufacturing method therefor


A biosensor and a method for manufacturing the biosensor. The biosensor comprises an insulative substrate (1), an electrode system (2, 3, and 4), a reagent, and an insulating layer (5).
Lead (hk) Limited


05/19/16
20160139010 

System and processing biological specimens


A system for processing biological specimens mounted on microscope slides by adding and removing processing fluids from microscope slides by means of capillary action using a slide holder capable of holding multiple microscope slides, and a spacer positioned in between two slides of a slide pair to create a capillary gap. A capillary gap adjuster can be used to pinch and release one end of the slide pair to create a pulsatile action to mix the reagent within the capillary gap.

05/19/16
20160138452 

Reagent dosing system and dosing reagent


A reagent dosing system for dosing a reagent into the exhaust gas stream of an internal combustion engine includes a reagent tank for storing a supply of reagent; an injector module including an atomising dispenser and a positive-displacement metering pump which draws reagent from the reagent tank and delivers it to the dispenser; a supply line coupling the reagent tank to the injector module; a dosing control unit operable to control the injector module to inject reagent into the exhaust gas stream; and an additional priming pump arranged, in use, to urge reagent along the supply line toward the injector module under selected conditions.. .
Delphi International Operations Luxembourg S.a.r.l


05/19/16
20160138098 

Container accommodation body


A container accommodation body includes: a package; a container that is accommodated and sealed in the package while accommodating and sealing a reagent for performing a nucleic acid amplification reaction; and a drying agent that is accommodated and sealed in the package.. .
Seiko Epson Corporation


05/19/16
20160138091 

Methods and systems for determining spatial patterns of biological targets in a sample


The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets.
Prognosys Biosciences, Inc.


05/19/16
20160138090 

Determination of intracellular bacteria


This application pertains to methods for the whole-cell analysis of intracellular bacteria. The methods are capable of making a determination of whether or not a sample (e.g.
Stender Diagnostics


05/19/16
20160138085 

Cartridge set


A cartridge set includes: a first package; a cleaning container that is accommodated and sealed in the first package while accommodating and sealing a cleaning solution for cleaning a nucleic acid-binding solid-phase carrier to which nucleic acid adheres; a second package; an elution container that is accommodated and sealed in the second package while accommodating and sealing an elution solution which elutes the nucleic acid from the nucleic acid-binding solid-phase carrier; a third package; and a reaction container that is accommodated and sealed in the third package while accommodating and sealing a reagent for performing a nucleic acid amplification reaction, in which the first package has water permeability that is lower than that of the cleaning container, the second package has water permeability that is lower than that of the elution container, and the third package has water permeability that is lower than that of the reaction container.. .
Seiko Epson Corporation


05/19/16
20160138084 

Cartridge set


A cartridge set includes: a first package; a cleaning container that is accommodated and sealed in the first package while accommodating and sealing a cleaning solution for cleaning a nucleic acid-binding solid-phase carrier to which nucleic acid adheres; an elution container that is accommodated and sealed in the first package while accommodating and sealing an elution solution which elutes the nucleic acid from the nucleic acid-binding solid-phase carrier; a second package; and a reaction container that is accommodated and sealed in the second package while accommodating and sealing a reagent for performing a nucleic acid amplification reaction. The first package has water permeability that is lower than that of the cleaning container and the elution container.
Seiko Epson Corporation


05/19/16
20160138075 

Determining usability of analytical test strip


A system for determining usability of an analytical test strip includes a sample chamber to receive a fluid sample, a reagent in the sample chamber having a moisture-varying impedance, and two detection electrodes contacting the reagent. A test meter applies an ac waveform across the reagent via the detection electrodes while measuring an impedance of the reagent.
Cilag Gmbh International


05/19/16
20160138010 

Instrument for cassette for sample preparation


A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system..
Luminex Corporation






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