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Reagent patents



      
           
This page is updated frequently with new Reagent-related patent applications. Subscribe to the Reagent RSS feed to automatically get the update: related Reagent RSS feeds. RSS updates for this page: Reagent RSS RSS


Date/App# patent app List of recent Reagent-related patents
08/14/14
20140228601
 Methods for recovering chlorinated hydrocarbons patent thumbnailMethods for recovering chlorinated hydrocarbons
Processes for isolating 1,1,1,2,3-pentachloropropane from a crude product stream containing the 1,1,1,2,3-pentachloropropane and ferric chloride. The processes may include deep distillation of the crude, treatment of the crude with a reagent that deactivates the ferric chloride followed by distillation on the deactivated crude stream, aqueous washing of the crude product stream to remove ferric chloride followed by distillation on the deactivated crude stream.
08/14/14
20140228597
 Process for the manufacture of dihalodiphenylsulfones starting from organic acids patent thumbnailProcess for the manufacture of dihalodiphenylsulfones starting from organic acids
A process for the preparation of dihalodiphenylsulfones_such as 4,4′-dichlorodiphenyl sulfone or 4,4′-bis-(4-chlorophenylsulfonyl)biphenyl with high regioselectivity, at low temperature and in the absence of toxic reagents by reacting together at least one acid, sulfur trioxide and at least one halobenzene. The invented process is particularly suited for the manufacture of 4,4′-dichlorodiphenyl sulfone..
08/14/14
20140228516
 Bispecific intracellular delivery vehicles patent thumbnailBispecific intracellular delivery vehicles
A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a ph-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target..
08/14/14
20140228484
 Polymer, process and use patent thumbnailPolymer, process and use
There is described a process for producing a gel free hyperbranched polyamide polymer p having a polydispersity of at least 1.1 and a weight average molecular weight of at least 300 daltons, having primary amino groups (useful as a crosslinker). The process comprises the step of reacting reagent a, a compound comprising at least one amino group (—nh2) and one functional group selected from the group consisting of a further amino group (—nh2), thiol (—sh) and a secondary amine radical (—nhr); (where r denotes a hydrocarbo group) (=functional amine) and reagent b, an alpha-beta unsaturated michael-reactive ester comprising a plurality of ester groups (=diester); in a molar ratio of amine a to diester b greater than 1 but less than 3 (preferably 2.1 to 2.9); to form the polyamide in a two stage reaction michael addition and then amidation.
08/14/14
20140228256
 Method and kit for constructing plasma dna sequencing library patent thumbnailMethod and kit for constructing plasma dna sequencing library
The disclosure relates a method and a kit for constructing a plasma deoxyribonucleic acid (dna) sequencing library. The method provided by the disclosure includes: extracting a plasma dna; making the plasma dna ligate to a sequencing linker, and purifying a ligation product; performing polymerase chain reaction (pcr) amplification for the purified ligation product, purifying the pcr amplification product, and obtaining the plasma dna sequencing library, wherein, the method does not include the step of performing 5′-terminus phosphorylation for the plasma dna.
08/14/14
20140228251
 Sirna targeting catenin, beta-1 (ctnnb1) patent thumbnailSirna targeting catenin, beta-1 (ctnnb1)
Efficient sequence specific gene silencing is possible through the use of sirna technology. By selecting particular sirnas by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.
08/14/14
20140228244
 Calibration reagent and method patent thumbnailCalibration reagent and method
The present invention relates to a method for calibrating a multiplex assay, comprising: adding a calibration reagent to a solid phase on which a plurality of capturing agents are immobilised, adding a detection molecule which has a capacity to bind to the calibration reagent, detecting bound detection molecule, thereby creating a calibration curve, wherein the calibration reagent comprises at least two different binding molecules, wherein each binding molecule has a capacity to bind specifically to a capturing agent immobilised on the solid phase and a capacity to bind to a detection molecule. Further provided is a multiplex assay system comprising such a calibration reagent..
08/14/14
20140228229
 Methods for identifying and monitoring drug side effects patent thumbnailMethods for identifying and monitoring drug side effects
The present invention relates generally to methods for identifying drug side effects by detecting perturbations in organ-specific molecular blood fingerprints. The invention further relates to methods for identifying drug-specific organ-specific molecular blood fingerprints.
08/14/14
20140227800
 Method for stabilizing glycerophospholipids and reagents using same patent thumbnailMethod for stabilizing glycerophospholipids and reagents using same
Disclosed is an accurate and stable immunoassay reagent using a glycerophospholipid and a method for stabilizing the reagent. The reagent for assaying an analyte in blood by immune reaction with an antigen when the analyte is an antibody or with an antibody when the analyte is an antigen, wherein a glycerophospholipid and a polyvinylpyrrolidone are incorporated into the immune reaction system..
08/14/14
20140227796
 Devices and methods for the collection and detection of substances patent thumbnailDevices and methods for the collection and detection of substances
The present invention provides a single self-contained device for collecting, extracting, on-site testing, and transferring for forensic confirmatory analysis, a wide variety of substances including, but not limited to, drugs of abuse, explosives, weapons of mass destruction, food toxins and industrial wastes. Samples can be obtained from a surface by swabbing a suspect area or the testing of solid materials (pills, capsules, powders), air samples and biological and non-biological fluids by placing the substance in the device.
08/14/14
20140227793
Compositions and methods for glycan sequencing
Compositions and methods directed to a glycan reagent for depolymerization of a glycan having a reducing end, the glycan reagent being represented by the formula mcx, in which m is a glycan coupling group selected from oxylamines and hydrazides; c is a fixed charge group or a basic group having a proton affinity of at least 210 kcal/mol; and x is hydrogen or a free radical initiator chemically coupled to c.. .
08/14/14
20140227770
Uses of reagents in sample collection and cartridge systems
A sample collection container and a cartridge system employ reagent bodies having reagents confined by a restraining agent. The sample collection container comprises one or more reagent bodies, each having one or more reagents confined by a restraining agent.
08/14/14
20140227721
Reagent zone deposition pattern
An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone that includes a reagent cell having a line of symmetry in the direction of fluid flow; a reagent material in the reagent cell, wherein the reagent material includes a first reagent material located at the axis of symmetry and is left-right symmetric, and a second and third reagent material having a substantially identical shape and volume and located in mirror locations from the line of symmetry; a detection zone in fluid communication with the reagent zone; and a wicking zone in fluid communication with the detection zone having a capacity to receive liquid sample flowing from the detection zone. The sample addition zone, the detection zone and the wicking zone define a fluid flow path..
08/14/14
20140227714
In situ heat induced antigen recovery and staining apparatus and method
An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another.
08/14/14
20140227707
Reagent patterning in capillarity-based analyzers and associated systems and methods
The present technology describes various embodiments of devices for processing, analyzing, detecting, measuring, and separating fluids. The devices can be used to perform these processes on a microfluidic scale, and with control over fluid and reagent transport.
08/14/14
20140227694
Epigenetic markers of pluripotency
Epigenetic methods for assessing pluripotency of a cell population, such as a stem cell culture are provided. For example, pluripotency can be assessed by determining dna methylation status at the rab25, nanog, ptpn6, mgmt, gbp3 and/or lyst gene regions.
08/14/14
20140227693
Genetic markers for risk management of atrial fibrillation, atrial flutter, and stroke
The invention relates to procedure and methods of determining a susceptibility to cardiac arrhythmia, including atrial fibrillation, atrial flutter and stroke, by assessing the presence or absence of alleles at polymorphic markers found to be associated with atrial fibrillation, atrial flutter and stroke. The invention further relates to kits encompassing reagents for assessing such markers, and diagnostic methods, uses and procedures for utilizing such susceptibility markers..
08/14/14
20140227428
Preparation method for medical porous tantalum implant material
A preparation method for medical porous tantalum implant material is provided, which includes mixing polyethylene glycol aqueous solution and tantalum powder to form tantalum slurry, casting the tantalum slurry into an organic foam body through vibrant pressurization, and going through steps of drying, degreasing, vacuum sintering and thermal treatment to obtain the porous tantalum. The solution is a 2-8 wt % polyethylene glycol aqueous solution, the frequency of vibration is 20-80 times/min, the thermal treatment is performed under 10−4-10−3 pa of vacuity and the temperature is increased to 800-900° c.
08/14/14
20140227299
Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
Where one or more nemorubicin metabolite or analog drug moieties (d) are covalently attached by a linker (l) to an antibody (ab) which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be useful in methods of diagnosis or treatment of cancer, and other diseases and disorders..
08/14/14
20140227218
Pharmaceutical compositions of conjugates formed from polymer derivatives having particular atom arrangements
Pharmaceutical compositions of conjugates are provided. The conjugates can be prepared by (among other ways) conjugating a pharmacologically active agent with a polymeric reagent that has a particular arrangement of atoms.
08/14/14
20140227146
System and method for processing biological samples
A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem including an actuation substrate, and a set of pins interacting with the actuation substrate, and a spring plate configured to bias at least one pin in a configurations, the valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; and a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols.. .
08/14/14
20140224672
Test strip, detecting device and detecting method
A test strip, a detecting device, and a detecting method are disclosed. The test strip includes a first specimen path, a first electrode set, a second specimen path, a second electrode set, and a reaction reagent.
08/14/14
20140224382
Reagent bottle cap, system, method and apparatus for handling closure caps and like
A reagent bottle includes an outer cap and an inner closing cap. The inner closing cap has a recess for gripping the cap.
08/07/14
20140221626
Compositions and methods for detection of methadone metabolite
Methods and reagents are disclosed for conducting assays for eddp. The reagents include a moiety selected from the group consisting of poly(amino acid) label moieties, non-poly(amino acid) label moieties, poly(amino acid) immunogenic carriers, non-poly(amino acid) immunogenic carriers, non-label poly(amino acid) moieties, and non-immunogenic carrier poly(amino acid) moieties linked to 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine at the 3-position of one of the phenyl rings.
08/07/14
20140221505
Methods and compositions for categorizing patients
The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in diagnostic tests, nucleic acid and amino acid sequences related to the molecular markers, reagents for detection of molecular markers, and methods for identifying candidate molecular markers in highly parallel gene expression data.. .
08/07/14
20140221484
Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
08/07/14
20140221477
Process for the preparation of a sulfated derivative of 3,5-diiodo-o-[3-iodophenyl]-l-tyrosine
The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-o-[3-iodo-4-(sulphooxy)phenyl]-l-tyrosine (t3s) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained t3s compound may conveniently be isolated in a pure form as a solid in good yields.
08/07/14
20140221433
N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
The present invention relates to an improved and shortened synthesis of n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide and the mesylate monohydrate salt thereof by using boronic acid derivatives or borolane reagents while avoiding toxic organic tin compounds and to the mesylate monohydrate salt of n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions.. .
08/07/14
20140221253
Synthetic antibodies
Methods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.. .
08/07/14
20140221224
Single tube multiplex assay for detection and quantification of adulterants in basmati rice samples
The present invention provides a single tube multiplex assay for distinguishing basmati from non-basmati rice varieties, and thereby identifying the adulteration of basmati rice varieties. The present invention further provides a method for quantifying adulteration in basmati rice varieties.
08/07/14
20140220705
Automated analyzer and analyzing method
An analyzer provides conditions suitable for a reagent for performing latex immunoassay with a high sensitivity using a method of measuring scattered light. Irradiation light having a wavelength in the range of 0.65 to 0.75 μm is used, and scattered light generated from a reaction solution is received at a light-receiving angle of 15° to 35° with respect to the irradiation direction during the rotational movement of the reaction container.
08/07/14
20140220679
Methods and compositions for categorizing patients
The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in diagnostic tests, nucleic acid and amino acid sequences related to the molecular markers, reagents for detection of molecular markers, and methods for identifying candidate molecular markers in highly parallel gene expression data.. .
08/07/14
20140220667
Device for pathogen detection
There is provided a portable device for detecting pathogens in a sample, the detection being based on an assay involving one or more reagents and heat. The device comprises a flexible substrate having a plurality of spaced apart reservoirs along its length, each reservoir adapted for receiving reagents and the sample, the substrate being secured to a pair of spaced apart reels and movable there between by rolling.
08/07/14
20140220666
Self contained in-vitro diagnostic device
A portable apparatus for measuring a glucose level of a user having: a card-like member; a processor within the card-like member; at least one glucose sensor comprising a reagent, the glucose sensor generating a signal indicative of a measured glucose level upon application of a blood sample to the glucose sensor, wherein the glucose sensor is fixed to the card-like member and operably coupled to the processor; and at least one cover alterable between a first position in which the glucose sensor is covered and a second position in which the glucose sensor is exposed for use.. .
08/07/14
20140220608
Reagentless ceria-based colorimetric sensor
A colorimetric reagent in the form of nanoparticles, composite nanoparticles, and nanoparticle coatings, including methods of use, methods of preparation, deposition, and assembly of related devices and specific applications. The colorimetric reagent comprises cerium oxide nanoparticles which are used in solution or immobilized on a solid support, either alone or in conjunction with oxidase enzymes, to form an active colorimetric component that reacts with an analyte to form a colored complex.
08/07/14
20140220600
Proteins expressed by mycobacterium tuberculosis and not by bcg and their use as diagnostic reagents and vaccines
The present invention is directed to reagents useful for generating immune responses to mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to m. Tuberculosis..
08/07/14
20140220593
Inhibition of peroxidase enzymatic activity
The present invention deals with reagents and compositions capable of effectively inhibiting peroxidase activity. According to the invention, peroxidase enzymatic activity is blocked with an acidic aqueous solution of a protein denaturing agent.
08/07/14
20140220589
Ultrasensitive detection of beta hemolytic streptococcus
The present invention is directed to a method for the ultrasensitive detection of beta hemolytic streptococcus, a bacterium implicated in strep throat, using a specific protease marker. Also disclosed is a device as well as a biosensor, both of which are useful for the detection of beta hemolytic streptococcus.
08/07/14
20140220575
Artificial selection method and reagents
The present invention provides methods for estimating the breeding value of individuals in populations such as those having small effective population size (ne) e.g., to identify selection candidates having high breeding values, wherein the methods comprise inferring one or more genotypes for one or more markers at a locus or qtl to be the same as for an ancestor or founder or a subset of ancestors and/or founders from which a corresponding chromosome segment is derived and estimating the breeding value of the individual based on the inferred genotype(s).. .
08/07/14
20140220571
Transgenic plant event detection
The present invention relates to detection of materials derived from transgenic plant events. In particular, the invention provides methods, reagents, kits and reference materials for detecting the presence or absence in a sample of genetic material derived from and attributable to select transgenic plant events..
08/07/14
20140220559
Method to determine dna mismatch repair function
This invention relates to a quantitative method for determining whether a human subject has an impaired dna mismatch repair function; providing a diagnostic sample taken from said human and producing a nuclear extract from said sample; providing mmr proficient and mmr deficient nuclear extracts as positive and negative controls, respectively; combining each nuclear extract with at least one mismatch bearing substrate dna molecule; performing a mismatch repair assay; and determining whether said sample nuclear extract is capable of repairing said substrate dna molecule; wherein said sample comprises normal, non-malignant constitutive cells, such as fibroblasts. The invention further relates to a kit providing necessary reagents for use in said method..
08/07/14
20140219985
Disease control with tick phospholipase a2
The present invention relates to reagents and methods for the modulation of viability of bacteria. A process is provided wherein a protein sequence from a.
08/07/14
20140219046
Mixing apparatus and methods
A method and apparatus for the mixing of a solution and reagents for pcr reactions having a closed cartridge reaction well, a magnetically responsive bead within the well having an optically inert coating and a secondary chemically inert coating. A heat source then heats the contents to a target temperature while oscillating magnetic fields move the bead within the well in order to mix the contents and make the contents of the reaction well homogeneous..
08/07/14
20140216987
Process for concentrating manganese ores via reverse cationic flotation of silicates
A process for concentrating manganese from the tailing of a manganese-carrying mineral including removing a coarse particle size fraction from the tailing, desliming and conducting an acidic or a basic reverse cationic flotation. The manganese-carrying minerals are typically minerals with low manganese content from the lithologies “tabular pelite” (or petb), pelite siltite (or pest), detritic (or detr), rich pelite (or perc) and metallurgical bioxide (or bxme).
08/07/14
20140216949
Mediator-stabilized reagent compositions for use in biosensor electrodes
The claimed subject matter relates to the stabilization of 1,2-quinone mediators, especially those containing 1,10-phenanthroline quinone (pq) and more especially transition metal complexes of pq, in the presence of enzymes when contained in dry reagent layers for biosensor electrodes, through the use of various metal salts, particularly those of lithium.. .
07/31/14
20140213789
Stannyl derivatives of naphthalene diimides and related compositions and methods
Naphthalene diimide (ndi) compounds can be functionalized with tin reagent to provide a useful, versatile synthetic tool. One embodiment provides, for example, a composition comprising at least one ndi compound comprising at least one stannyl substituent bonded to the naphthalene moiety of the ndi compound.
07/31/14
20140213761
Diphenylmethane compound
The present invention aims to provide a compound superior in broad utility and stability, which is useful as a protecting reagent (anchor) of amino acid and/or peptide in liquid phase synthesis and the like of a peptide having a c-terminal etc., which are of a carboxamide (—conhr)-type, an organic synthesis reaction method (particularly peptide liquid phase synthesis method) using the compound, and a kit for peptide liquid phase synthesis containing the compound, and has found that the object can be achieved by a particular compound having a diphenylmethane skeleton.. .
07/31/14
20140213637
Agents for improved delivery of nucleic acids to eukaryotic cells
New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes..
07/31/14
20140213532
Compositions and methods for enhancing drug delivery across and into epithelial tissues
This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier.
07/31/14
20140213486
Compensator for multiple surface imaging
A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples.
07/31/14
20140213481
Method for the simultaneous determination of blood group and platelet antigen genotypes
Rbc and platelet (plt) alloimmunization requires antigen-matched blood to avoid adverse transfusion reactions. Some blood collection facilities use unregulated abs to reduce the cost of mass screening, and later confirm the phenotype with government approved reagents.
07/31/14
20140213480
Method for the simultaneous determination of blood group and platelet antigen genotypes
Rbc and platelet (plt) alloimmunization requires antigen-matched blood to avoid adverse transfusion reactions. Some blood collection facilities use unregulated abs to reduce the cost of mass screening, and later confirm the phenotype with government approved reagents.
07/31/14
20140213478
Srm/mrm assay for the receptor tyrosine-protein kinase erbb-4 protein (her4)
Ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded. A protein sample is prepared from the biological sample using the liquid tissue™ reagents and protocol and the her4 protein is quantitated in the liquid tissue™ sample by srm/mrm mass spectrometry by quantitating in the protein sample at least one or more of the peptides described.
07/31/14
20140213464
System and apparatus for sequential processing of analytes
An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control.
07/31/14
20140212987
Signal ratio in assay calibrators
Methods of enhancing signal ratio between calibrators in an assay for an analyte include conducting an assay for the analyte with zero concentration of analyte in a first calibrator to determine a first signal level. The reagents employed in the assay comprise an antibody reagent comprising an antibody for the analyte wherein a hinge region of the antibody is conjugated to a moiety.
07/31/14
20140212960
Leukocyte measurement device and reagent kit
A leukocyte measurement device is provided with a spread inspection window at a position separated from an opening part along a spreading direction of a blood-derived sample in a carrier, for making the carrier visible from outside. When the blood-derived sample is dropped from the opening part, leukocytes contained in the blood-derived sample are captured by the carrier in the vicinity of a dropping position, while erythrocytes and/or hemoglobin and the like spread through the carrier from the dropping position into a predetermined direction.
07/31/14
20140212959
Sperm quality assessment device
A novel sperm quality assessment device includes a main frame and a test pad. The test pad is encircled by the main frame and includes an exposed introductory portion.
07/31/14
20140212958
Lysis and reverse transcription for mrna quantification
The present invention is directed to a method for performing an rt-pcr for amplifying a target rna including the steps of (i) cultivation of a population of adherent cells in a cell culture vessel (ii) lysis of the population of adherent cells which is supposed to contain the target rna in the sample vessel with a lysis buffer comprising between 0.05 m and 1 m of a chaotropic agent (iii) adding reagents to the sample vessel which are necessary to perform a reverse transcription reaction such that the chaotropic agent is present in a concentration of about 10 to 60 mm in the sample vessel, and reverse transcribing the target rna and (iv) amplifying the first strand cdna by means of subjecting the sample to multiple cycles of a thermocycling protocol.. .
07/31/14
20140212903
Azo mediators and methods of use thereof
Azo compounds are disclosed that do not form azoxy dimers and that do not have any reactive nitroso groups. Also disclosed are use of the azo compounds as mediators in optical and electrochemical diagnostic methods, as well as detection reagents, kits and test elements that include such azo compounds and that can be used in the diagnostic methods..
07/31/14
20140212892
Method for automated tissue analysis
The invention provides an improved method for identifying and interpreting tissue specimens and/or cells derived from tissue specimens. A panel of cell-based reagents provides a number of readouts of cellular states or biomarkers that together define a profile of a diversity of cellular states or biomarkers in a tissue specimen representing the ‘systems” nature of biology.
07/31/14
20140212447
Rift valley fever virus glycoproteins, gn and gc, and their use
The present invention describes subunit vaccines containing gn and gc glycoproteins of the rift valley fever virus, including nucleic acids encoding such glycoproteins, host cells, vectors, and immunoreagents generated with the glycoproteins, methods of vaccination, methods of diagnosis, and kits.. .
07/31/14
20140212403
Chemically modified cystathionine beta-synthase enzyme for treatment of homocystinuria
The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine β-synthase (cbs) to treat homocystinuria and other related diseases and disorders.. .
07/31/14
20140212344
Plug application and removal device and sample processing device
The present invention is such a plug application and removal device that mist which is generated upon plug removal of a sample container or a reagent container is not peripherally scattered, or is such a sample processing device that mist which is generated upon dispensing of a sample or a reagent into a container is not mixed to another container. A plug application and removal device has a container holding mechanism that holds a container housing liquid inside and applied with a plug, and has a plug application and removal mechanism that removes or applies the plug from/to the container.
07/31/14
20140212336
Liquid analysis apparatus
A rotary analytical device for use with a reagent cartridge. The cartridge may have a housing, an axis, analysis chambers spaced from and located circumferentially about the axis, and a magnetically movable element located in and movable within each analysis chamber to mix fluid in the analysis chamber.
07/31/14
20140212333
Static fluid disinfecting systems and related methods
Static fluid disinfecting system and related methods. Implementations of a method of disinfecting a fluid include statically contacting a fluid included in in a container with an open-celled foam where the open-celled foam is coated with a quaternary organosilane coating produced from a quaternary ammonium organosilane reagent where the fluid contains one or more microorganisms..
07/31/14
20140210136
Binding bisphenol a in a polycarbonate container
Embodiments of the disclosure provide a method for removing residual bpa from a residual bpa-containing substance and a method for making a container with residual bpa removed. The method may consist of preparing a stabilization reagent, wherein water is removed from the stabilization reagent.
07/31/14
20140209523
Water treatment process and plant using ballasted flocculation and settling
A method for treating wastewater using a ballasted flocculation technique includes continuously measuring the concentration of suspended solids, organic matter or other impurities in the water to be treated prior to directing the water to be treated to a flocculation tank. Based on this measurement, the amount of ballast necessary to obtain treated water of a predetermined quality is then calculated.
07/31/14
20140209486
Detecting device and method applying a detecting strip
A detecting device and method applying an electrochemical detecting strip are disclosed. The detecting device is used to detect by applying an electrochemical detecting strip having at least one cavity on the upper surface thereof with the cavity being coated with reaction reagent.
07/24/14
20140206903
Novelcrosslinking reagents, macromolecules, therapeutic conjugates, and synthetic methods thereof
The invention provides novel chemical entities based on sugar alcohols. These new chemical entities are biocompatible and biodegradable.
07/24/14
20140206884
Process using grignard reagents
The present invention relates to a process using grignard reagents for providing thio-triazolo group-containing compounds.. .
07/24/14
20140206776
Mrm/srm assay for death receptor 5 protein
Specific peptides, and derived ionization characteristics of those peptides from death receptor 5 (dr5) protein are provided that are particularly advantageous for quantifying the dr5 protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring/multiple reaction monitoring (srm/mrm) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
07/24/14
20140206775
Srm/mrm assay for the fatty acid synthase protein
Specific peptides, and derived ionization characteristics of the peptides, from the fatty acid synthase (fasn) protein are provided that are particularly advantageous for quantifying the fasn protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
07/24/14
20140206603
Engineered polypeptide agents for targeted broad spectrum influenza neutralization
The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (ha) polypeptides and/or ha receptors, and reagents and methods relating thereto.
07/24/14
20140206578
Process for determining the concentration of nucleic acids
A process is disclosed for determining the concentration of nucleic acids in a sample in a microfluidic device. In at least one embodiment, the method includes a) introducing the sample into a first chamber, b) carrying out a number of cycles of an amplification reaction to be carried out in cycles for amplifying nucleic acids, c) transferring a defined volume which is a fraction of the volume of the first chamber and which has amplified nucleic acids into a second chamber and replacing the transferred defined volume with fresh reagents for the amplification reaction, d) determining the concentration of the amplified nucleic acids in a second chamber equipped with an element to determine concentrations, and e) repeating steps b)-d) until a concentration of the amplified nucleic acids which is within a range is determined in the second chamber.
07/24/14
20140206574
Methods and compositons for the treatment and diagnosis of cancer
The invention relates to methods of detecting cancer in a sample obtained from a subject. The invention also provides kits and reagents for detecting cancer as well as therapeutics and methods of treating cancer..
07/24/14
20140206564
Reagents for improving pcr accuracy
Provided herein are reagents for improving pcr accuracy.. .
07/24/14
20140206557
Novel reagents for directed biomarker signal amplification
Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors.
07/24/14
20140206098
Low volume assay device having increased sensitivity
An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample addition zone containing a reagent material; a detection zone in fluid communication with the reagent zone. The detection zone has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a capillary space between the projections capable of generating capillary flow parallel to the substrate surface.
07/24/14
20140206088
Unitized reagent strip
The embodiments disclosed herein relate to unitized reagent strips for holding and transporting reagents and materials used in automated sample preparation and/or processing for biological and or chemical assays.. .
07/24/14
20140206073
Microfluidic system for nucleic acid analysis
A microfluidic system for analyzing nucleic acid, the microfluidic system including a reagent supply device including a sample chamber into which a sample can be injected, one or more reagent chambers for containing one or more reagents for extracting nucleic acid from the sample, and a waste chamber in which the used reagent can be discarded; a binding-lysis chamber in which cells are captured from the sample and lysed to form a cell lysate containing nucleic acid; plurality of particles for cell binding disposed in the binding-lysis chamber; a plurality of rehydration chambers into which the cell lysate formed in the binding-lysis chamber can be distributed and mixed with a nucleic acid amplification reagent to form an amplification reaction mixture; a plurality of amplification chambers in which a nucleic acid amplification reaction is performed on the amplification reaction mixture introduced from the plurality of rehydration chambers; and a flow channel system including an outlet and a plurality of inlets connected to the reagent supply device and forming an integrated fluid flow between the binding-lysis chamber, the rehydration chambers, and the amplification chambers.. .
07/24/14
20140206024
Stable nad/nadh derivatives
The present invention provides for stable nicotinamide adenine dinucleotide (nad/nadh) and nicotinamide adenine dinucleotide phosphate (nadp/nadph) derivatives of formula (i), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.. .
07/24/14
20140206010
Methods and kits for detecting mastitis
Methods and kits for determining if one or more animals have mastitis and for monitoring animals and the quality of the milk they produce are disclosed. Kits and test assays disclosed are used to determine the quantity of proteasomes and proteins thereof, the activity of proteasome enzymes, the quantity of proteasome bound and regulating proteins, and the quantity of ubiquinated protein.
07/24/14
20140206002
Methods of diagnosing breast cancer
The disclosed subject matter is based on the discovery that a mutation (a single nucleotide polymorphism or “snp”) in the gene encoding abraxas (also referred to as abra1, ccdc98 or fam175a), is associated with susceptibility to cancer, e.g., breast cancer. In particular, the disclosed subject matter is based on the identification of a heterozygous alteration in the abraxas gene that is associated with breast cancer and specifically correlated with familial cancer.
07/24/14
20140206001
Methods and compositions for enrichment of nucleic acids in mixtures of highly homologous sequences
Provided are methods of enrichment and detection of target nucleic acids during target amplification in the presence of excess amounts of highly homologous sequences, said methods having substantial diagnostic utility (e.g., cancer diagnostics). Provided are amplification reaction mixtures having at least one cleavage-directing oligonucleotide, the respective binding sites of which, for the target and homologous sequences, include one or more nucleotide positions differing in sequence between the target homologous sequences.


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