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Reagent patents



      
           
This page is updated frequently with new Reagent-related patent applications. Subscribe to the Reagent RSS feed to automatically get the update: related Reagent RSS feeds. RSS updates for this page: Reagent RSS RSS


Date/App# patent app List of recent Reagent-related patents
11/13/14
20140336336
 Process for preparing cured polymers patent thumbnailProcess for preparing cured polymers
The present invention relates to curing of polymers, particularly to self curing of polymers. The present invention provides a process for curing of copolymers of isoolefins and olefinic monomers.
11/13/14
20140336302
 Curable water soluble epoxy acrylate resin compositions patent thumbnailCurable water soluble epoxy acrylate resin compositions
A water soluble epoxy acrylate resin composition including a reaction product of (a) at least one diepoxide resin or a diepoxide resin blended with other epoxy resins; (b) at least one carboxylic acid; and (c) at least one basic reagent in an amount sufficient to form a water soluble epoxy acrylate resin product; a process for preparing the above water soluble epoxy acrylate resin composition; a curable water soluble epoxy acrylate resin composition including (i) the epoxy acrylate resin composition described above, and (ii) at least one initiator; a process for preparing the curable water soluble epoxy acrylate resin composition described above; a process for curing the curable water soluble epoxy acrylate resin composition described above; and a cured product made therefrom.. .
11/13/14
20140336281
 Srm/mrm assay for the ephrin typa-a receptor 2 protein patent thumbnailSrm/mrm assay for the ephrin typa-a receptor 2 protein
Specific peptides, and derived ionization characteristics of the peptides, from the ephrin type-a receptor 2 (epha2) protein are provided that are particularly advantageous for quantifying the epha2 protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
11/13/14
20140336156
 Antibodies to 25-hydroxyvitamin d2 and d3 and uses thereof patent thumbnailAntibodies to 25-hydroxyvitamin d2 and d3 and uses thereof
Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin d derivative, such as 25-hydroxyvitamin d2 and/or 25-hydroxyvitamin d3, or a 25-hydroxyvitamin d analog, such as a vitamin d-c22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described.
11/13/14
20140336076
 Method for diagnosing and treating fibromyalgia patent thumbnailMethod for diagnosing and treating fibromyalgia
The invention provides methods, kits and reagents for diagnosing fibromyalgia (fm) in an individual by determining whether the levels of one or more cytokines in the individual are altered, as compared to control levels. The altered level(s) or patterns of expression of the cytokines measured in the affected individual compared to the level from the control is predictive/indicative of fm in the.
11/13/14
20140335627
 Method and apparatus for storing and dispensing reagent beads patent thumbnailMethod and apparatus for storing and dispensing reagent beads
Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In some embodiments, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells.
11/13/14
20140335525
 Cutoff point delta ct. method for her2 pcr testing in breast cancer patent thumbnailCutoff point delta ct. method for her2 pcr testing in breast cancer
The present invention is related to an improved method for her2 gene test by using quantitative real-time pcr (polymerase chain reaction) technique. Our invention streamlines test process, and incorporates quality control for each major step, including sample, reagent, operation, and data report.
11/13/14
20140335520
 Direct nucleic acid analysis patent thumbnailDirect nucleic acid analysis
The present disclosure provides methods, systems, and apparatuses for collecting and/or amplifying nucleic acids. In general, provided methods, systems, and apparatuses involve contacting a sample including a nucleic acid with a nucleic acid amplification reagent without purification of nucleic acids from the sample..
11/13/14
20140335518
 Encapsulated reagents and methods of use patent thumbnailEncapsulated reagents and methods of use
The present invention contemplates use of encapsulated aqueous and non-aqueous reagents, solutions and solvents and their use in laboratory procedures. These encapsulated aqueous or non-aqueous reagents, solutions and solvents can be completely contained or encapsulated in microcapsules or nanocapsules that can be added to an aqueous or non-aqueous carrier solution or liquid required for medical and research laboratory testing of biological or non-biological specimens..
11/13/14
20140335517
 Detection and treatment of schizophrenia patent thumbnailDetection and treatment of schizophrenia
The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia.
11/13/14
20140335167
Consumer products comprising silane-modified oils
A consumer product comprises silane-modified oil comprising a hydrocarbon chain selected from the group consisting of: a saturated oil, an unsaturated oil, and mixtures thereof; and at least one hydrolysable silyl group covalently bonded to the hydrocarbon chain. The silane-modified oil is substantially stripped of substantially stripped of reagents prior to formulating into the consumer products, such that the silane-modified oil comprises less than about 10%, preferably less than about 5%, preferably less than about 1%, preferably less than about 0.1%, by weight of said silane-modified oil, of residual reagent comprising silicon..
11/13/14
20140335094
Mammalian cytokines; related reagents and methods
Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided..
11/13/14
20140334988
Flow reversing exhaust gas mixer
An exhaust mixing device for mixing an exhaust produced by an engine with a reagent exhaust treatment fluid that is dosed into the exhaust from a dosing module. The exhaust mixing device includes a decomposition tube having a first end and a second end.
11/13/14
20140334987
Axial flow atomization module
An exhaust treatment component for treating an engine exhaust. The component includes a housing including an inlet and an outlet, and a mixing assembly located within the housing between the inlet and the outlet.
11/13/14
20140334986
Axial flow atomization module
An exhaust treatment component for treating an engine exhaust including a housing including an inlet and an outlet. A mixing device is located within the housing between the inlet and the outlet, and the mixing device includes a shell communicating with the outlet, a decomposition tube having a first end and a second end, and a flow reversing device disposed proximate the second end.
11/13/14
20140334982
Apparatus for treating a gas stream
An apparatus for treating a gas stream includes a plasma abatement device that has a reaction chamber and a plasma torch for generating a plasma stream for injection into the chamber for treating the gas stream. A first inlet conveys a gas stream into the plasma abatement device for treatment, and a second inlet, in a normal condition of the apparatus, is in flow communication with a source of reagent for conveying a reagent into the plasma device for improving the efficiency of the treatment.
11/13/14
20140332389
Kit for co-purification and concentration of dna and proteins using isotachophoresis
A kit for separating and concentrating nucleic acid and protein targets includes labeled reagents which affect simultaneous co-purification and concentration of a nucleic acid and a protein, a gel isotachophoresis separation unit to which a sample comprising the nucleic acid and the protein is added, a detection unit for the detection of the presence of the nucleic acid and the protein, and instructions for use. The gel electrophoresis includes a gel box having a negative electrode side and a positive electrode side, the negative electrode side being filled with a first buffer comprising 2-hydroxy-n-(tris(hydroxymethyl)methyl)-3-aminopropanesulfonic acid buffer and the positive electrode side being filled with a second buffer being different than the first buffer.
11/13/14
20140332388
Method for producing high purity crystalline carbamide
The invention relates to the method for producing high purity crystalline carbamide. The method comprises the crystallization and drying of carbamide, wherein an aqueous carbamide solution is preheated from +30° c.
11/13/14
20140332377
Sample-retainable biosensor test strip
A biosensor test strip includes: a first working electrode and a second working electrode formed on a base plate, having the second working electrode circumferentially surrounding the first working electrode to define a reaction pool within the second working electrode having a biological reagent provided in the reaction pool. Upon feeding a liquid sample of a user or patient into the reaction pool, the liquid sample will be well retained in the reaction pool to be reacted with the reagent to produce a signal which is then converted to be a readable data as displayed on a measurement apparatus or meter..
11/13/14
20140332098
Method and system for pre-programmed self-power microfluidic circuits
A major challenge for the general use of “lab-on-a-chip” (loac) systems and point-of-care (poc) devices has been the generally complex and need for sophisticated peripheral equipment, such that it is more difficult than anticipated to implement low cost, robust and portable loac/poc solutions. It would be beneficial for chemical, medical, healthcare, and environmental applications to provide designs for inexpensive loac/poc solutions compatible with miniaturization and mass production, and are potentially portable, using compact possibly hand-held instruments, using reusable or disposable detectors.
11/06/14
20140330000
Molecular cartesian-coordinate platforms
A compound of formula mol-m-l, wherein m is a 5 or 6-coordinate metal, l is a bidentate ligand, and mol is a compound of formula (ii): (ii) wherein x is c and r\ r2, r3, r4, r5, r6, r7, r8, r9, r10, r11 and r12 are as defined herein. In another embodiment, a system comprises a substrate and a compound of the present disclosure immobilized on the substrate.
11/06/14
20140329990
Hydroxyapatite-targeting multiarm polymers and conjugates made therefrom
The present invention provides, among other things, polymeric reagents suitable for reaction with biologically active agents to form conjugates, the polymeric reagents comprising one or more polymer chains and a plurality of hydroxyapatite-targeting moieties, and optionally the reagents include one or more degradable linkages that serve to divide the polymer chains into polymer segments having a molecular weight suitable for renal clearance.. .
11/06/14
20140329946
Rubber composition and manufacturing method for same
The present invention is a rubber composition containing a rubber component, a specific hydroxy group-having thiourea derivative, a thioamide compound, an acidic compound, a combination of a nucleophilic reagent except guanidine compounds and a guanidine compound, a compound selected from a phosphorous acid compound and a salt of a phosphorous acid compound, and a filler containing an inorganic filler, and a method for the rubber composition, providing the rubber composition having an improved low-heat-generation property and its production method.. .
11/06/14
20140329701
Kiaa1456 expression predicts survival in patients with colon cancer
The invention relates to methods for deciding on the therapy in a subject suffering from colorectal cancer as well as for predicting the clinical outcome of a patient which suffers from colorectal cancer based on the expression level of kiaa1456 comprising determining the expression level of the kiaa1456 gene. The invention relates as well to kits and uses thereof comprising reagents adequate for the determination of the expression level of the kiaa1456 gene..
11/06/14
20140329694
Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing
A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell.
11/06/14
20140329335
Magnetic particle detection with incubation period
The invention relates to a method and a device for the detection of magnetic particles (1) in a sample chamber (112). After introduction of the sample into said sample chamber (112), the magnetic particles (1) are first retained within the sample chamber (112) and kept away from the sensing surface (111) by an appropriate magnetic field (b) to allow for an incubation of the sample with reagents.
11/06/14
20140329331
Novel cyanine derivatives having meso-reactive functional group at polymethine chain and preparation method thereof
The present invention relates to a novel cyanne derivative having a meso-reaction functional group in a polymethine chain, and a preparation method thereof, and the cyanine derivative having the reaction functional group substituted at the meso site may be suitable for mass production thanks to a very simple synthesis method, have a very fast reaction rate because while a related art reagent for detection of nerve agents undergoes two steps of reactions, the cyanine derivative of the present invention undergoes only one step of reaction, have very excellent sensitivity, and be useful as an acid ph-activated ratiometric nir probe because it is able to be activated in an acidic ph and is usable in an aqueous environment.. .
11/06/14
20140329303
In-vitro contact lens testing
Contact lens testing apparatuses and method for testing contact lenses for analytes are presented. In an aspect, a device is provided that includes a housing configured to hold one or more contact lenses, and a testing compartment provided within the housing and comprising a reagent, the reagent configured to facilitate a chemical reaction in response to the existence of a predetermined biomarker disposed on or within a contact lens placed in the testing compartment, wherein the chemical reaction produces a known result related to state information of an individual from which the biomarker was generated..
11/06/14
20140329300
Device for analyzing a sample and method of using the same
This disclosure is directed to a device and method of using the device to analyze a sample. The sample may be a suspension, a portion of the suspension, a particular component of the suspension, or the like.
11/06/14
20140329272
Metal-based covalent viability reagent for single cell analysis
The present invention provides a robust viability stain for methods utilizing elemental analysis. A population of cells is contacted with an effective dose of a non-chelated biomacromolecule-reactive metal derivative, which selectively crosses the plasma membrane of non-viable cells, and which covalently modifies a biological macromolecule within the cell, for a period of time sufficient to permit entry into non-viable cells.
11/06/14
20140329270
Automated system and method of treating tissue samples on slides
An automated method and system for treating one or more tissue samples disposed on slides, the system comprising: a controller, a plurality of slide treatment modules arranged to receive ones of the slides; at least one fluid dispensing robot configured by the controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules via an output nozzle disposed on the at least one fluid dispensing robot to treat said one or more tissue samples respectively; and at least one pumping means for pumping said reagents to the output nozzle of the at least one fluid dispensing robot from a plurality of reagent containers comprising said reagents, wherein the at least one fluid dispensing robot is configured by the controller to dispense said reagents in a predetermined sequence for each of the slide treatment modules to treat the one or more tissue samples disposed on each of the slides independently.. .
11/06/14
20140329235
Sensor housing and reagent chemistry
A sensor comprises a sensor housing, having a channel; a porous substrate, in the channel; an analysis chemistry reagent, on the porous substrate; and a nozzle, in fluid connection with the channel. The porous substrate fills a cross section of the channel, and the cross-sectional area of the channel at the porous substrate is greater than the cross-sectional area at the nozzle..
11/06/14
20140329025
Solid precursor-based delivery of fluid utilizing controlled solids morphology
Apparatus and method for volatilizing a source reagent susceptible to particle generation or presence of particles in the corresponding source reagent vapor, in which such particle generation or presence is suppressed by structural or processing features of the vapor generation system. Such apparatus and method are applicable to liquid and solid source reagents, particularly solid source reagents such as metal halides, e.g., hafnium chloride.
11/06/14
20140328842
Predicting responsiveness to antibody maintenance therapy
Methods, reagents and kits are provided for predicting whether an individual suffering from an antibody dependent cell-mediated cytotoxicity (adcc)-treatable disease is responsive to an antibody maintenance therapy. The methods, reagents, and kits find a number of uses, including, for selecting individuals who will be responsive for treatment with an antibody maintenance therapy, for determining the appropriate maintenance therapy for an individual suffering from an adcc-treatable disease, for determining the optimal regimen for antibody maintenance therapy, and for treating an individual with an antibody maintenance therapy based on stratification into responsive groups..
11/06/14
20140328754
Radioactive metal-labeled anti-cadherin antibody
A radioactive metal-labeled anti-cadherin antibody which is obtained by binding a radioactive metallic element to an anti-cadherin antibody via a metal-chelating reagent.. .
11/06/14
20140328733
Simplified gating method for sealing and flow control in micro and nano devices
A biochip for multiplex genetic identification is disclosed. An biochip for separating and detecting a plurality of dna fragments includes a set of inputs and chambers for receiving a sample matrix of genetic material and reagents needed to conduct a polymerase chain reaction amplification of the genetic material.
11/06/14
20140326871
Atmospheric pressure ion source for mass spectrometry
A multiple function atmospheric pressure ion source interfaced to a mass spectrometer comprises multiple liquid inlet probes configured such that the sprays from two or more probes intersect in a mixing region gas phase sample ions or neutral species generated in the spray of one probe can react with reagent gas ions generated from one or more other probes by such ionization methods as electrospray, photoionization, corona discharge and glow discharge ionization. Reagent ions may be optimally selected to promote such processes as atmospheric pressure chemical ionization of neutral sample molecules, or charge reduction or electron transfer dissociation of multiply charged sample ions.
11/06/14
20140326599
Electrochemical test sensor with light guide
An electrochemical test sensor for detecting the analyte concentration of a fluid test sample includes a base, a dielectric layer, a reagent layer, a light guide area, and a lid. The base provides a flow path for the test sample haying on its surface a counter electrode and a working electrode adapted to electrically communicate with a detector of electrical current.
10/30/14
20140323819
Multi-parameter test units for initial indication of medical symptoms
Disposable test units to assist medical personnel are described. In some embodiments, a test unit includes: a solid support; a cavity in the solid support; a reaction chamber internal to the solid support, including a plurality of biochemical reagents; a first internal channel in the solid support, connected at a first end to the cavity, connected at a second end to the reaction chamber; at least one pathogen detection region internal to the solid support; a second internal channel in the solid support, connected at a first end to the reaction chamber, connected at a second end to the at least one pathogen detection region; a temperature detector; and a persistent visible temperature indicator attached to the temperature detector..
10/30/14
20140323747
Process for the synthesis of aminaphtone
The present invention concerns a new process for the synthesis of aminaphtone, which makes use of non-toxic solvents and reagents, under mild reaction and temperature conditions. The aminaphtone obtained with the method of the present invention also has a purity of at least 98% in weight.
10/30/14
20140323742
Methods for preparing polymeric reagents and compositions of polymeric reagents
Methods for preparing active carbonate esters of water-soluble polymers are provided. Also provided are other methods related to the active carbonate esters of water-soluble polymers, as well as corresponding compositions..
10/30/14
20140323710
Sequences and their use for detection and characterization of stec bacteria
This invention relates to a rapid method for detection and characterization of stec bacteria based on the presence of nucleic acid sequences, in particular, to a pcr-based method for detection, and to oligonucleotide molecules and reagents and kits useful therefore. This method is preferably employed to detect stec bacteria in a food or water sample, such as a beef enrichment.
10/30/14
20140323688
Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines
This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (cppt), 1-cyano-imidazole (1-ci), 1-cyanobenzotriazole (1-cbt), or 2-cyanopyridazine-3(2h)one (2-cpo), or a functional derivative or modification thereof.
10/30/14
20140323581
Transcriptome wiring analysis in parkinson's disease and uses thereof
The invention is directed to methods to identify predisposition or risk to develop parkinson's disease, methods to identify agents which have therapeutic effect on parkinson's disease, and methods to determine the therapeutic effect of an agent in a subject suffering from parkinson's disease, and to kits and reagents for carrying out the methods of the invention.. .
10/30/14
20140323546
Pme-1 as a biomarker to predict and diagnose an increased risk of endometrial cancer and gene silencing of pme-1 to inhibit epithelial to mesenchymal transition
Disclosed are methods of attenuating activity of the pme-1 gene. Sirnas or shrnas are used to target against pme-1, thereby reducing the pme-1 mrna.
10/30/14
20140323405
Alpha-1-antitrypsin compositions
A streamlined method for purifying alpha-1-antitrypsin (aat) from an aat-containing protein mixture, such as a cohn fraction iv precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect aat.
10/30/14
20140323340
Sensitive and rapid determination of antimicrobial susceptibility
The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration.
10/30/14
20140323315
Polyspecificity reagents, methods for their preparation and use
The present invention relates, inter alia, to polyspecificity reagents, methods of making the same, and methods of using the same in, inter alia, the selection, screening, enrichment, and identification of non-polyspecific, and thus developable, polypeptides.. .
10/30/14
20140322826
Method for detection of binding
The present invention relates to a method for detection of binding or interaction events between a binding agent and its corresponding analyte (such as an antibody and an antigen) in which a signal is detected which is substantially more amplified and thus easier to detect than in prior art systems. The method comprises simultaneous but separate addition of a first enhancement reagent having affinity for said analyte and a second enhancement reagent having affinity for the first enhancement reagent wherein the first enhancement reagent binds to the analyte and the second enhancement reagent binds to the first enhancement reagent, and, wherein the first and second enhancement reagents have more than one binding site so that they are able to bind to each other to thereby amplify a detectable signal from the binding event..
10/30/14
20140322817
Mass spectrometer
A mass spectrometer is disclosed comprising an electron transfer dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell.
10/30/14
20140322802
Apparatus for measuring blood cells and immunity from whole blood
In conventional apparatuses for measuring blood cells and immunity from whole blood, the crp cell is used for the final cleaning of a nozzle, and crp measurement—cleaning of the crp cell—final cleaning of nozzle are performed in this order in the crp cell. In contrast, in the present invention, an exclusive cleaning chamber a for immunity measurement is further provided for the cleaning nozzle after completion of dispensing the specimen and the reagent(s) for crp measurement to the crp cell.
10/30/14
20140322761
Method of preparing sample for nucleic acid amplification reaction, nucleic acid amplification method, and reagent and microchip for solid phase nucleic acid amplification reaction
Provided is a method of preparing a sample for nucleic acid amplification reaction, including: a procedure of dissolving a solid phase reagent at least containing dna polymerase, cyclodextrin, and a binder, in a liquid containing a nucleic acid.. .
10/30/14
20140322749
Method for measuring color change of oxidation-reduction indicator
Provided is a method for measuring a color change of an oxidation-reduction indicator, which method is applicable to measurement of the cariogenic bacterial count and the like. A color change of an oxidation-reduction indicator is measured by a method for measuring a color change of an oxidation-reduction indicator, the method comprising reacting a test reagent with a test sample and measuring a color change, wherein the test reagent contains an oxidation-reduction indicator, an oxidation-reduction promoter, and a halogen salt..
10/30/14
20140322737
Fast reaction kinetics of enzymes having low activity in dry chemistry layers
The present invention concerns a method for determining an analyte as well as a diagnostic element suitable therefore. In one particular form, a method for determining an analyte includes contacting a sample containing the analyte with a diagnostic element comprising a dry reagent layer.
10/30/14
20140322538
Luminescent nanostructured materials for use in electrogenerated chemiluminescence
“a nanostructured particulates formed from a redox active, luminescent phenyl substituted polycyclic aromatic hydrocarbon are provided herein. The nanostructured particulates may be used for determining the presence of an analyte of interest in a sample by detecting the emitted electromagnetic radiation generated by exposing a reagent mixture, which includes the nanostructured particulates and the sample, to electrochemical energy.”.
10/30/14
20140322245
Srm/mrm assay for the insulin receptor protein
Specific peptides, and derived ionization characteristics of the peptides, from the insulin receptor protein (ir), and its isoforms ir-a and ir-b, that are particularly advantageous for quantifying the ir protein, ir-a isoform and/or ir-b isoform, directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
10/30/14
20140322102
Reagent preparation and dispensing device
A reagent preparation and dispensing device includes a body having a reaction chamber for a reagent and a solution reservoir for a solution. The solution reservoir is isolated from the reaction chamber.
10/30/14
20140322099
Microfluidic chips and assay systems
The systems and methods described herein include a microfluidic chip having a plurality of microfeatures interconnected to provide a configurable fluid transport system for processing at least one reagent. Inserts are provided to removably interfit into one or more of the microfeatures of the chip, wherein the inserts include sites for interactions with the reagent.
10/30/14
20140322083
Curing systems for materials that consume carbon dioxide and method of use thereof
The invention provides a curing system that is useful for curing materials that consume carbon dioxide as a reagent. The system has a curing chamber that contains the material to be cured and a gas that contains carbon dioxide.
10/30/14
20140322080
Automatic analysis device
Disclosed is an automatic analysis device that enables easy selection of a desired reagent-setting position and efficient execution of reagent information confirmation and reagent usage setup, by displaying, at a high level of visibility and in an enlarged format, both of the selected reagent-setting position and means for moving, for example, a mouse pointer to an anterior or posterior display position with respect to the selected reagent-setting position. A display controller 312a displays a list of reagent-setting positions provided in a reagent disk 301.
10/30/14
20140320642
Device and method for detecting substances present in biological or chemical samples
The present invention relates to a device and a method for detecting substances which are present in biological or chemical samples, each substance producing an optically detectable signal upon reaction with a reagent. The device further comprises a sample support with at least two containers for receiving samples and is characterized by a camera for recording an image which shows at least two containers, and an evaluation device for evaluating the samples which device is designed such as to evaluate each image by analyzing the signals in the image.
10/30/14
20140319032
Compact wastewater concentrator and contaminant scrubber
A compact and portable liquid concentrator and contaminant scrubber includes a gas inlet, a gas exit and a flow corridor connecting the gas inlet and the gas exit, wherein the flow corridor includes a narrowed portion that accelerates the gas through the flow corridor. A liquid inlet injects liquid into the gas stream at a point prior to the narrowed portion so that the gas-liquid mixture is thoroughly mixed within the flow corridor, causing a portion of the liquid to be evaporated.
10/30/14
20140318633
Multilevel microfluidic systems and methods
Multilevel microfluidic devices include a control line that can simultaneously actuate valves for both sample and reagent lines. Microfluidic devices are configured to contain a first reagent in a first chamber and a second reagent in a second chamber, where either or both of the first and second reagents are contained at a desired or selected pressure.
10/23/14
20140316117
Polymers and plastics derived from animal proteins
The invention is directed to a method for preparing a polymer derived from an animal protein, such as in a feedstock derived from animal by-products. The method involves hydrolyzing proteins present in a feedstock to obtain hydrolyzed proteins, wherein hydrolysis is conducted under conditions sufficient to digest the proteins and destroy pathogens; extracting a protein fraction from the hydrolyzed proteins; and treating the protein fraction with a crosslinking reagent to form the polymer.
10/23/14
20140316111
Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines
This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (cppt), 1-cyanoimidazole (1-ci), 1-cyanobenzotriazole (1-cbt), or 2-cyanopyridazine-3(2h)one (2-cpo), or a functional derivative or modification thereof.
10/23/14
20140316110
Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines
This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (cppt), 1-cyano-imidazole (1-ci), 1-cyanobenzotriazole (1-cbt), or 2-cyanopyridazine-3(2h)one (2-cpo), or a functional derivative or modification thereof.
10/23/14
20140316100
Method for preparing polymethylene polyphenyl polycarbamate
A method for preparing polymethylene polyphenyl polycarbamate is provided, which is carried out through the condensation of phenylcarbamate with a methylating reagent under the catalyzation of a phase transfer acid catalyst. The method comprises: dissolving phenylcarbamate in a water-immiscible organic solvent to form a solution a; formulating an aqueous acid catalyst solution to fibrin a solution b; forming a reaction system comprising an organic phase and an aqueous phase by firstly adding a methylating reagent to the solution b and then mixing the solution a and the solution b or by adding the methylating reagent at the same time of mixing the solution a and the solution b or after mixing the solution a and the solution b; reacting the reaction system under stirring at a reaction temperature of 30° c.
10/23/14
20140315762
Methods for tagging dna-encoded libraries
The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2′-substituted nucleotides, such as 2′-o-methyl or 2′-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation..
10/23/14
20140315750
Selective detection of norovirus
A process for detecting norovirus nucleic acid in a sample is provided including producing an amplification product by amplifying a norovirus nucleotide sequence using a forward primer of seq id no: 1, 4, or 10 and a reverse primer of seq id no: 2, 5, or 11, and detecting the amplification product to detect norovirus in the sample. Also provided are reagents and methods for detecting and distinguishing gi or gil norovirus from other infectious agents.
10/23/14
20140315724
Methods and systems for sequencing long nucleic acids
The present invention provides methods and systems for sequencing long nucleic acid fragments. In one aspect of the invention, methods, systems and reagent kits are provided for sequencing nucleic acid target sequences.
10/23/14
20140315321
Chloride ion fluorescence detection method and device, and use thereof
A chloride ion fluorescence detection method and device, and a use thereof. The chloride ion fluorescence detection method utilizes chloride ions to influence luminescence characteristics of some photoluminescent substances to change the emission spectrum of the photoluminescent substances.
10/23/14
20140315315
Protein detection
The present invention relates to reagents for separating proteins from detergent, reagents for detecting proteins in the presence of a detergent, and methods of using the same. The separating reagents contain a cyclic oligomer such as cyclodextrin and a cellulose derivative such as 2-hydroxyethyl cellulose.
10/23/14
20140315285
Lignocellulosic detection device
A lignocellulosic detection device includes a lignocellulosic substrate and at least one detection reagent absorbed/coated to lignocellulosic tissue of the lignocellulosic substrate. A liquid specimen is in contact with the lignocellulosic substrate so as to be absorbed to the lignocellulosic tissue of the lignocellulosic substrate by capillary action and react with the detection reagent to achieve specimen detection.
10/23/14
20140315256
Cover member, method and treatment module for treating a biological sample on a substrate
A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber.
10/23/14
20140315233
Buffered histology and cytology stains
A composition for use in staining histological and cytological tissue and cell samples which includes a buffer component in a staining solution. Specifically, the invention relates to stains and methods of producing stains for histological and cytological microscopic evaluation of tissue and cells.
10/23/14
20140315228
Apparatus and method for analyzing blood clotting
Systems, apparatuses and methods include evaluation the clotting time or strength of clotting in the presence of various clot-affecting reagents to obtain a profile of clot analysis for determination of bleeding complications. The various reagents may be included in a single cartridge for use in a blood clotting analysis device..
10/23/14
20140315226
Device and method for detecting substances present in biological or chemical samples
The present invention relates to a device and a method for detecting substances which are present in biological or chemical samples, each substance producing an optically detectable signal upon reaction with a reagent. The device further comprises a sample carrier with at least two receptacles for receiving samples and is characterized in that at least part of the receptacle is equipped to receive at least 2 reagents each, and in that a camera for recording an image which shows at least one receptacle filled with at least two reagents for the detection of different substances, and an evaluation device for evaluating the samples which device is designed such as to evaluate each image by analyzing the signals in the image.
10/23/14
20140315224
Detection device, detection strip, and detection system
A detection device applied for detecting body fluids includes a substrate and a plurality of anti-growth factor antibodies. The substrate includes at least one reaction portion.
10/23/14
20140315218
New method for evaluation of target in histological sample
The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. In particular, the invention relates to a method and reagents for detection, visualization and quantification of a molecular target in immunostained histological samples using particular compositions of the target specific binding agent.
10/23/14
20140315216
Immunoassay test slide
An immunoassay test slide for use in a dry chemistry analytical instrument includes a slide housing or case formed from two matable sections—a slide cover piece and a slide bottom piece. The slide housing defines an interior cavity in which is situated a sheet-like porous carrier matrix.
10/23/14
20140315215
Thermostable assay reagents
There is provided a single-chain fusion protein comprising: (i) a thermostable kinase and (ii) a single-domain antibody or single-domain antibody fragment. There is also provided a method of preparing a single-domain antibody or single-domain antibody fragment, the method comprising: (i) expressing the single-domain antibody or antibody fragment as a single-chain fusion protein with a thermostable kinase, in a host cell such as e.
10/23/14
20140315214
Chaperone interaction assays and uses thereof
In some aspects, the invention provides methods of identifying, detecting, and/or measuring protein-protein interactions. In some aspects, the invention provides methods of identifying and/or characterizing modulators of protein-protein interactions.
10/23/14
20140315197
Multifunctional probe-primers
Methods and reagents for detection and analysis of nucleic acids are provided. Certain methods involves an encoding amplification in which a target sequence is associated with probe-binding sequences and optionally with indexing sequences, (2) an optional distribution step in which the product of the encoding amplification is split into multiple aliquots, and (3) a decoding and detection step in which the presence, absence, quantity, or relative amount of the target sequence in the aliquots is determined.


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