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Reagent patents



      
           
This page is updated frequently with new Reagent-related patent applications. Subscribe to the Reagent RSS feed to automatically get the update: related Reagent RSS feeds. RSS updates for this page: Reagent RSS RSS



Date/App# patent app List of recent Reagent-related patents
07/23/15
20150204871 
 Automated immunoanalyzer system for performing diagnostic assays for autoimmune and infectious diseases patent thumbnailAutomated immunoanalyzer system for performing diagnostic assays for autoimmune and infectious diseases
A quantitative method for diagnosing an autoimmune disease or an infectious disease comprising performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex, wherein the capture reagent is a biotinylated autoantigen or infectious disease antigen; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.. .
Hycor Biomedical, Inc.


07/23/15
20150204867 
 Automated immunoanalyzer system for performing diagnostic assays for autoimmune and infectious diseases patent thumbnailAutomated immunoanalyzer system for performing diagnostic assays for autoimmune and infectious diseases
A quantitative method for diagnosing an autoimmune disease or an infectious disease comprising performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex, wherein the capture reagent is a biotinylated autoantigen or infectious disease antigen; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.. .
Hycor Biomedical, Inc.


07/23/15
20150204813 
 Detection of methylated dna patent thumbnailDetection of methylated dna
The use of ion sensitive field effect transistor (isfet) to detect methylated nucleotides in a dna sample is described. A method of detecting methylated nucleotides in a dna sample may include the steps of treating a sample of dna with a reagent which discriminates between methylated and non-methylated nucleotides to provide treated dna, amplifying the treated dna and optionally sequencing the amplified dna.
Oncu Limited


07/23/15
20150204794 
 Automatic analyer patent thumbnailAutomatic analyer
An automatic analyzer which can reduce the effort necessary for conducting a test of limit of detection/limit of quantification properties and managing the test results is provided. Operation condition-setting means for conducting an evaluation test for at least one of a limit of detection and a limit of quantification for each measurement item, determination condition-setting means for setting a determination condition of the evaluation test, and a calculation unit for obtaining a measurement result of a dilution series containing different dilution concentrations by controlling the sample-dispensing mechanism, the reagent-dispensing mechanism and the measurement unit based on the set operation condition, and calculating a test result of the evaluation test from the measurement result of the dilution series based on the set determination condition are disposed..
Hitachi High-technologies Corporation


07/23/15
20150204764 
 Encapsulated reagents and methods of use patent thumbnailEncapsulated reagents and methods of use
The present invention contemplates use of encapsulated aqueous and non-aqueous reagents, solutions and solvents and their use in laboratory procedures. These encapsulated aqueous or non-aqueous reagents, solutions and solvents can be completely contained or encapsulated in microcapsules or nanocapsules that can be added to an aqueous or non-aqueous carrier solution or liquid required for medical and research laboratory testing of biological or non-biological specimens..

07/23/15
20150203904 
 Nucleic acid amplification and detection kit patent thumbnailNucleic acid amplification and detection kit
A nucleic acid amplification and detection kit, including: a buffer storage assembly, including a buffer storage reservoir storing a buffer solution therein; a nucleic acid amplification assembly including a nucleic acid amplification reservoir storing one or more reagents therein and configured to receive a sample containing nucleic acid for amplification therein, wherein the buffer storage assembly is configured to couple with the nucleic acid amplification assembly to seal within the nucleic acid amplification reservoir the sample containing nucleic acid and amplification products of the amplification; and a test strip assembly including a lateral flow test strip disposed therein, the test strip assembly and the coupled nucleic acid amplification and buffer storage assemblies being configured to couple with one another and including one or more solution release components to release the amplification products from the nucleic acid amplification reservoir onto the lateral flow test strip for testing, and to release the stored buffer solution from the buffer storage reservoir to flush the released amplification products along the lateral flow test strip.. .
Axxin Pty Ltd


07/23/15
20150203575 
 Pilr alpha interactions and methods of modifying same patent thumbnailPilr alpha interactions and methods of modifying same
Described herein is a novel receptor-ligand interaction and agents that may modify and/or block the interaction. Methods, uses, reagents and kits for the modulation of ligand activities related to its interaction with the novel receptor are disclosed.
Genentech, Inc.


07/23/15
20150203533 
 Method of recovering peptide and  detecting peptide patent thumbnailMethod of recovering peptide and detecting peptide
Disclosed is a method of recovering a peptide, including: mixing a liquid sample containing a complex of peptide and protein in blood with a reagent containing a neutral amino acid, an acidic amino acid or both the neutral and acidic amino acids to liberate the peptide from the protein in blood; and recovering the liberated peptide.. .
Sysmex Corporation


07/23/15
20150202568 
 Systems and methods for acid gas removal from a gaseous stream patent thumbnailSystems and methods for acid gas removal from a gaseous stream
Apparatuses, systems, and methods for removing acid gases from a gas stream are provided. Gas streams include waste gas streams or natural gas streams.
Skyonic Corporation


07/16/15
20150198621 
 Analyzing apparatus, solid-liquid separation device and solid-liquid separation method patent thumbnailAnalyzing apparatus, solid-liquid separation device and solid-liquid separation method
An analyzing apparatus is described, a representative one of which includes: rotatable table arranged with a plurality of holes for accommodating the reaction container which includes a specimen and a reagent; and a container transferring section, arranged on the rotatable table, for transferring the reaction container.. .
Sysmex Corporation


07/16/15
20150198606 

Method for enhancing transport of semiconductor nanocrystals across biological membranes


Semiconductor nanoparticle complexes comprising semiconductor nanoparticles in association with cationic polymers are described. Also described are methods for enhancing the transport of semiconductor nanoparticles across biological membranes to provide encoded cells.
Life Technologies Corporation


07/16/15
20150198602 

Theranostic method based on the detection of her2-her2 dimers


The invention also relates to a kit of reagents for implementing this method.. .

07/16/15
20150198594 

Test cartridge for use in rapid analysis of biological samples


A test cartridge for use in sample analysis is provided. The test cartridge includes a reservoir card that further includes a reagent that includes living biological cells; and a test cartridge base configured to accept the reservoir card.
Fundamental Solutions Corporation


07/16/15
20150198581 

Method, mobile application, and system for providing food safety map


A method for providing food safety map comprises: immersing a reagent block of a food safety testing sheet into a specimen; using camera of a mobile device to take a picture of the reagent block to obtain a reactive image; analyzing the reactive image to obtain a food safety information; obtaining an address information according to the location; transmitting the food safety information and the address information to a server through a wireless connection; using that server to map the food safety information to a map according to the address information; and publishing the map to the internet.. .
National Tsing Hua University


07/16/15
20150198540 

Dry reagent based water analyzer


The invention provides devices, methods, and compositions for dry chemical reagents to measure calcium, magnesium (total hardness), and other analytes in water using colorimetric devices. The measurement may be a one-step procedure without the need of dilution and multi-step preparation, so that it can be easily employed by untrained personnel.
Ecolab Usa Inc.


07/16/15
20150198528 

Assay detection system


An assay system including reagents and devices for conducting rapid, high sensitivity analyte assays, including multiplexed assays, is described. The reagents and devices are adapted for performing time-resolved signal detection with low background due to non-specific binding.
Xen Biofluidx, Inc.


07/16/15
20150198525 

Automatic analyzer


To be adapted to various types of latex reagents for detecting scattered light and thereby measuring agglutination reactions with high sensitivity while sufficiently ensuring integration time. To be adapted to various types of latex particles of different particle sizes, a plurality of light receivers are arranged in a plane perpendicular to the direction of cell movement by rotation of a cell disk.
Hitachi High-technologies Corporation


07/16/15
20150198132 

Device for heating at least one component, in particular an internal combustion engine of a vehicle


A device (1) for heating at least one component (21), the device (1) comprising: —a pipe (2) capable of conveying a reaction fluid, —a reactor (3) capable of receiving a reagent likely to cause an exothermic reaction with the reaction fluid, the reactor (3) comprising at least one inlet for reaction fluid linked to the pipe (2) and at least one outlet for reaction fluid linked to the pipe (2), and —a circuit (10) for regenerating the reagent, the device comprising a generator (4) configured to generate a pressure lower than that inside the reactor (3) in an area of the pipe (4).. .
Valeo Systemes De Controle Moteur


07/16/15
20150197784 

System for rapid analysis of biological samples


A system for use in rapid sample analysis that includes a biosensor reagent, wherein the biosensor reagent includes living biological cells; a reservoir card, wherein the reservoir card stores the biosensor reagent; and a test cartridge base, wherein the test cartridge base is configured to accept the reservoir card, and wherein the test cartridge base further includes a reaction chamber having a central axis, wherein the reaction chamber has the shape of a revolved half ellipse; and an inlet channel connected to the reaction chamber, wherein the inlet channel is positioned above the reaction chamber at an angle of 15-60 degrees above the horizontal, and wherein the inlet channel is offset from the central axis of the reaction chamber.. .
Fundamental Solutions Corporation


07/16/15
20150197720 

Photothermal substrates for selective transfection of cells


This invention provides novel tools for surgery on single cells and substrates/devices for delivery of reagents to selected cells. In certain embodiments the substrates comprise a surface comprising one or more orifices, where nanoparticles and/or a thin film is deposited on a surface of said orifice or near said orifice, where the nanoparticles and/or a thin film are formed of materials that heat up when contacted with electromagnetic radiation.
The Regents Of The University Of California


07/16/15
20150197540 

Asymmetric auxiliary group


To provide a chiral reagent or a salt thereof. The chiral reagent has following chemical formula (i).
Chiralgen, Ltd.


07/16/15
20150197389 

Heat insulation cold closet for medical supplies


The invention relates to a heat insulation cold closet for medical supplies, comprising a closet body with an opening, and a cover body sealed and meshed with the opening; the closet body, from inside to outside, successively consists of a rigid polyurethane layer, a vacuum heat insulation panel layer, a foamed polyurethane panel layer and a housing. The coefficient of heat insulation is smaller than or equal to 0.004 w/mk, heat radiation, heat conduction and heat convection between the interior of the closet body and the external environment can be effectively prevented, and the heat insulation closet can guarantee that the interior temperature is controlled at 2-8° c.
Suzhou Antekpac Industrial Co., Ltd.


07/16/15
20150196916 

Device for use in molecular diagnostics testing


An actuator coupled to at least one of the reagent storage container and the opener such that moving the actuator brings the reagent storage container and the opener together so that the opener unseals the reagent storage container.. .

07/16/15
20150196568 

System for use by compounding pharmacists to produce hormone replacement medicine customized for each customer


This invention provides a system for compounding a pharmaceutical product for hormone replacement therapy. The system has a set of concentrated reagent compositions, each containing one or more steroid hormones dissolved in one or more solvents.

07/09/15
20150192828 

Color liquid crystal display panel


The present invention provides a color liquid crystal display panel, which includes: a plurality of layers of liquid crystal cells (2) that are arranged parallel to each other and bonding members (8) bonding the plurality of layers of liquid crystal cells (2). Each of the liquid crystal cells (2) includes a thin-film transistor substrate (20), a package substrate (30), and a dye-doped liquid crystal layer (40) sealed between the thin-film transistor substrate (20) and the package substrate (30).
Shenzhen China Star Optoelectronics Technology Co. Ltd.


07/09/15
20150192584 

Methods for liquid direct fluorescent antibody intracellular virus detection


The present invention describes a liquid direct fluorescence antibody assay that is rapid and sensitive to detect respiratory virus in infected cells. The assay includes centrifugation of the specimen, incubation of sample and reagents in solution, and detection of the absence or presence of respiratory virus.
Diagnostic Hybrids, Inc.


07/09/15
20150192576 

Methods and reagents for prevention and/or treatment of transplant rejection


The present invention relates to methods for determining the probability of transplant rejection based on the determination in the subject recipient of the transplant of the levels of antibodies specific for hyaluronic acid. The invention relates as well to methods for attenuating transplant rejection and compositions to prevent transplant rejection based on the depletion of anti-hyaluronic acid antibodies from the subject..
Fundacio Institut D'investigacio Biomedica De Bellvitge (idibell)


07/09/15
20150192573 

Sample analyzer


A sample analyzer comprising: a sample preparing section for preparing first and second measurement sample including reagent and sample; a first detector for detecting a predetermined component in the first measurement sample prepared by the sample preparing section; a second detector for detecting the predetermined component in the second measurement sample prepared by the sample preparing section; and a controller configured for performing operations, comprising: (a) controlling the first detector to detect the predetermined component in the first measurement sample prepared by the sample preparing section; (b) determining the reliability of the result detected by the first detector; (c) controlling the sample preparing section to prepare the second measurement sample from the same sample when the result has been determined to be unreliable; and (d) controlling the second detector to detect the predetermined component in the second measurement sample, is disclosed.. .
Sysmex Corporation


07/09/15
20150192543 

Integrated reagentless sample preprocessing for molecular diagnostics using a nanoporous membrane based microfluidic device


A device and associated method to concentrate cells such as bacteria/viruses, lyse them, and extract biomolecules such as dna is described. A nanoporous membrane is sandwiched between two microfluidic channels to create thousands of parallel nanopore traps for bacteria or viruses.

07/09/15
20150191870 

Treatment of filaments or yarn


A method for treating an aromatic polyamide filament or yarn to improve its adhesion to rubber wherein, the method comprises exposing the filament or yarn to a first mixture of reagents comprising multi-functional isocyanate oligomers and multi-functional epoxy oligomers, wherein the ratio of total isocyanate groups to total epoxy groups in the mixture is in the range of from 0.8 to 1.2, and heating the exposed filament or yarn to a temperature of at least 100 degrees c. Whereby the epoxy and isocyanate oligomers cross-link and form a network on the surface of the filament or yarn..
E I Du Pont De Nemours And Company


07/09/15
20150191819 

Source reagent-based delivery of fluid with high material flux for batch deposition


Systems, reagent support trays, particle suppression devices, and methods are disclosed. In one aspect, a system includes a vaporizer vessel having one or more interior walls enclosing an interior volume and a plurality of reagent support trays configured to be vertically stackable within the interior volume.
Entegris, Inc.


07/09/15
20150191798 

Hoxc6 and ovarian cancer methods and uses thereof


The present invention comprises novel methods, systems, devices, and kits to detect cancer in a patient using hoxc6. Methods and systems are presented herein to (1) determine differential gene expression in cancer tissue (e.g.
The Charlotte-mecklenburg Hospital Authority D/b/a Carolinas Healthcare System


07/09/15
20150191782 

Compositions and methods for improving nanopore sequencing


The present disclosure provides methods and reagents for improving nanopore-based analyses of polymers. Specifically, the disclosure provides a method of analyzing a polymer that includes a polymer analyte that contains an end domain that has at least one charged moiety.
University Of Washington Through Its Center For Commercialization


07/09/15
20150190816 

Revolver component for a reagent vessel, reagent vessel part and reagent vessel for a centrifuge and/or for a pressure-varying device


A revolver component for a reagent vessel for a centrifuge and/or for a pressure-varying device includes a revolver housing which is able to be installed in the reagent vessel. Provided on the revolver housing is a guide structure, which is able to be contacted using at least one elevation provided on one reagent vessel part of the reagent vessel or provided on a further revolver component.
Robert Bosch Gmbh


07/09/15
20150190522 

Transfection reagents


Wherein q is selected from the group consisting of n, o and s; l is any bivalent organic radical capable of linking each q, such as c, ch, (ch2)l, or {(ch2)i—y—(ch2)j}k, wherein y is selected from the group consisting of ch2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein y is optionally substituted by —x1-l′-x2—z or —z; r1 r6, independently of one another, are selected from the group consisting of h, —(ch2)p-d-z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wherein at least one of r1, r3, r4 and r6 is a straight chain or branched, cyclic, alkyl, alkenyl, alkynyl or aryl group; and anyone of r1, r3, r4 and/or r6 may optionally be covalently linked with each other, with y or with l when l is c or ch to form a cyclic moiety; z is selected from the group consisting of amine, spermiyl, carboxyspermiyl, guanidyl, spermidinyl, putricinyl, diaminoalkyl, pyridyl, piperidinyl, pyrrolidinyl, polyamine, amino acid, peptide, and protein; x1 and x2, independently of one another, are selected from the group consisting of nh, o, s, alkylene, and arylene; l′ is selected from the group consisting of alkylene, alkenylene, alkynylene, arylene, alkylene ether, and polyether; d is q or a bond; a1 and a2, independently of one another, are selected from the group consisting of ch2o, ch2s, ch2nh, c(o), c(nh), c(s) and (ch2)t; x is a physiologically acceptable anion; m, n, r, s, u, v, w and y are 0 or 1, with the proviso that when both m and n are 0 at least one of r, s, u and y is other than 0; i, j, k, l, p and are integers from 0 to about 100; q is an integer from 1 to about 1000; and a is the number of positive charge divided by the valence of the anion.. .

07/02/15
20150187517 

Structural composite battery with fluidic port for electrolyte


According to the invention there is provided a fluidic port (8-9) for a refillable structural composite electrical energy storage device(1), and a method of producing same. The device may be a battery or supercapacitor with first and second electrodes (2,3) which are separated by a separator structure (6), wherein the device contains an electrolyte (4) which may further contain active electrochemical reagents.
Bae Systems Plc


07/02/15
20150185242 

Automatic analyzer


There is provided an automatic analyzer including: a sample pipetting mechanism 7, reagent pipetting mechanisms 12a and 12b, mixing mechanisms 33a and 33b, a scattered light photometer 40, and an absorption photometer 41 all located on a transfer path of reaction cells 2 arranged circumferentially on a disk-shaped reaction disk 1, the reaction cells 2 being transferred in the circumferential direction by rotation of the reaction disk 1. Scattered light intensity and absorbance are controlled to be measured by causing the reaction cells 2 to move past a scattered light detection position and a transmitted light detection position in the same process of movement, the two positions being established beforehand on the transfer path.
Hitachi High-technologies Corporation


07/02/15
20150185236 

Blood coagulation time prolonging agent


Provided is a reagent, which prolongs a blood coagulation time sufficiently and enhances an optical change, thereby enabling a correct and high-sensitive blood coagulability test. The present invention provides a blood coagulation time prolonging agent, including, as an active ingredient, a guanidine compound represented by the following formula (1) or an acid addition salt thereof (in the formula, r1 represents a hydrogen atom, an amino group, or an alkyl group which may have a substituent)..
Sekisui Medical Co., Ltd.


07/02/15
20150185230 

Identification of patients with abnormal fractional shortening


The present invention relates to a method for assessing whether a subject shall be subjected to an imaging based diagnostic assessment. The method is based on the determination of the amount(s) of a cardiac troponin and/or fibroblast growth factor 23 (fgf-23) in a sample from the subject, and on the comparison of the, thus, determined amount(s) with a reference amount (reference amounts).
Roche Diagnostics Operations, Inc


07/02/15
20150185210 

Platelet measurement reagent, platelet measurement reagent kit, and platelet measurement method


A reagent for measuring platelets comprising nile blue hydrogensulfate, or nile blue and an acid, a reagent kit for measuring platelets comprising the reagent for measuring platelets, and a method for measuring platelets using the reagent or reagent kit.. .
Sysmex Corporation


07/02/15
20150185118 

Microfluidic devices and methods


Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices.
Fluidigm Corporation


07/02/15
20150184158 

Translocation and mutant ros kinase in human non-small cell lung carcinoma


In accordance with the invention, a novel gene translocation, (4p15, 6q22), in human non-small cell lung carcinoma (nsclc) that results in a fusion proteins combining part of sodium-dependent phosphate transporter isoform napi-3b protein (slc34a2) with proto-oncogene tyrosine protein kinase ros precursor (ros) kinase has now been identified. The slc34a2-ros fusion protein is anticipated to drive the proliferation and survival of a subgroup of nsclc tumors.
Cell Signaling Technology, Inc.


07/02/15
20150183895 

Polymer backbone element tags


Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including icp-ms. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user.
Fluidigm Canada Inc.


07/02/15
20150183738 

3-n-butyl-1-isoindolinone and use thereof for preventing or treating cerebral infarction


3-n-butyl-1-isoindolinone and use thereof for preventing or treating cerebral infarction. The compound is prepared by: 1) employing phthalimide as a starting reactant, contacting a nucleophilic grignard reagent with the original reactant to add an alkyl group to a carbonyl carbon of an amide bond of the original reactant, thus yielding an intermediate; and 2) removing an oxygen atom connected to a third carbon atom of the intermediate in the presence of boron trifluoride diethyl etherate as a catalyst and triethylsilane as a reductant..
Sun Yat-sen University


07/02/15
20150183145 

Plastic-metal composite material and manufacturing method thereof


Disclosed are a plastic-metal composite material and a manufacturing method thereof. The method including: s1.
Janus (dongguan) Precision Components Co., Ltd.


07/02/15
20150183009 

Composition for treating an excavation activity


A composition for treating an excavation activity includes a reagent suspended in foam to form a reagent-foam mixture. The reagent is selected to react with at least one of sulfides or bacteria in waste rock or tailings materials to reduce acid rock drainage.
Golder Associates Inc.


07/02/15
20150182966 

Field deployable small format fast first result microfluidic system


A field-deployable small format microfluidic system includes simplified, low-cost system control elements, optics, fluid control, and thermal control. An embodiment of a microfluidic chip includes a first plate having reagent wells and pneumatic ports formed therein, a second plate with reaction wells and microfluidic channels connecting each reaction well with one reagent well and one pneumatic port formed therein, and a printed circuit board with heater elements, a temperature sensor, and thermal vias providing thermal transfer through the pcb.
Canon U.s. Life Sciences, Inc.


07/02/15
20150182963 

Systems and methods for reagent storage


A microfluidic device for storing a reagent includes a single unit includes a first portion having a reagent storage chamber configured to hold a reagent. The device also includes a second portion having a reaction chamber configured to support the reagent during a reaction process to form a product.
General Electric Company


07/02/15
20150182910 

Apparatus and evaporating waste water and reducing acid gas emissions


An apparatus for evaporating waste water and reducing gas emissions includes an evaporator device (7, 31) configured to receiving a portion of flue gas emitted from a boiler unit (1) and waste water to directly contact the flue gas with the waste water to cool and humidify the flue gas and to dry solid particulates within the waste water. In some embodiments, the waste water may be a component of a mixture formed by a mixer device (25) prior to being contacted with the flue gas to humidify and cool the flue gas and dry solids within the waste water.
Alstom Technology Ltd


07/02/15
20150182421 

Specimen collection apparatus


A specimen collection apparatus is provided. The specimen collection apparatus may include a container, a funnel for removable insertion in an opening of the container, a funnel cover; a removable seal, and a dispensing apparatus sealed within the funnel cover in a reagent-specific atmosphere.
Alpha Tec Systems, Inc.


07/02/15
20150182156 

Quick test device and method


Test device (1) for testing a human or animal sample, such as blood or blood components, comprising a first part (2) and a second part (3), comprising co-operating first and second coupling elements (4, 5) for coupling the first part with the second part, and a sample absorbing and/or adsorbing element (17), wherein the first part comprises a fluid reservoir (20), and wherein the second part comprises at least one receptacle, wherein the fluid reservoir is reducible in volume for forcing a liquid contained therein through and/or along the adsorbing and/or absorbing element, forcing the sample such as blood or components thereof from the adsorbing and/or absorbing element into the receptacle, preferably into contact with at least one reagent (16) in the second part when the first and second part are connected or brought into connection with each other by at least the first and second coupling elements.. .
Fabpulous B.v.


06/25/15
20150177258 

Sh2 domain variants


The present invention relates to variant sh2 domains for binding a phosphotyrosine (ptyr)-containing peptide. The variant sh2 domains of the present invention include a parent sh2 domain having at least one amino acid substitution in a pre-defined region of 15 amino acid positions of the parent sr2 domain, wherein said at least one amino acid substitution increases the affinity of the variant sh2 domain for the ptyr-containing peptide relative to the parent sh2 domain.
The University Of Western Ontario


06/25/15
20150177244 

Parallel analysis of serum epcam and mmp7 to discriminate sepsis, necrotizing enterocolitis and normal control patients


Methods and compositions are provided for making a necrotizing enterocolitis (nec) or sepsis assessment of an individual. Aspects of the methods include detecting a biomarker or panel of biomarkers selected from mmp7, epcam, and crp.
The Board Of Trustees Of The Leland Stanford Junior University


06/25/15
20150177236 

Combined chemiluminescence and elisa automated sample reader


The automated reader operates within an enclosure also containing a sample rack and reagent rack, as well as a microtiter plate with multiple wells therein. The machine automatically loads sample and reagent into a well of the microtiter plate according to a testing protocol.
Gold Standard Diagnostics


06/25/15
20150177232 

Clinical specimen detector


A clinical specimen detector includes a clip having a clamping end and a pressing end; and wherein a pair of compressing slices are disposed on the clamping end, and a channel is disposed in the lower end of at least one of the pair of compressing slices. A detecting reagent test chip is attached to the outer surface of the compressing slice.
National Tsing Hua University


06/25/15
20150177183 

Reversible detection of ions with permselective membranes


The present invention relates to an electrochemical method using a permselective membrane for detection of ions in a sample. The permselective electrode includes a lipophilic reagent such as a neutral ionophore or an ion exchanger and a lipophilic ion, the lipophilic reagent being in molar excess relative to the lipophilic ion.
Universite De Geneve


06/25/15
20150177178 

Matrix stability compositions, test elements, test systems and methods of use thereof


reagent matrices and methods are disclosed for improving the stability of test elements with respect to degradation by humidity in the air. The reagent matrices and methods are based upon using an effective amount of a deliquescent material to decrease the sorption of water from the air by other components of a reagent matrix.
Roche Diabetes Care, Inc.


06/25/15
20150177147 

Biological fluid analysis system and method


A biological fluid analysis system and method for measuring optical characteristics of a sample of biological fluid using a commercially available portable computing device having a camera, such as a smart phone. The system includes a scope, a case that attaches to the portable computing device, and a software application that runs on the portable computing device.
Dairy Quality Inc.


06/25/15
20150176895 

Method of drying transport/storage containers for radioactive waste


A method of drying a transport/storage container for radioactive waste where the container holds water at least some of which is chemically bound with a boron compound. The method has the steps of first adding to the water in the container a reagent that frees the boron compound from the chemically bound water, and then removing by vacuum drying the water in the container including the water that has been freed of the boron compound..

06/25/15
20150176463 

Pressure swirl flow injector with reduced flow variability and return flow


A reagent injector with a cartridge design has a body with a reagent inlet, outlet, and a swirl chamber, which has an exit orifice that may be covered and uncovered by a solid, movable pintle. Reagent flows through the injector when the exit orifice is covered and uncovered to cool the injector.
Tenneco Automotive Operating Company, Inc.


06/25/15
20150176461 

Electromagnetically controlled injector having flux bridge and flux break


An injector for injecting a reagent includes an axially translatable valve member positioned within a housing. An electromagnet is positioned within the housing and includes a cylindrically-shaped coil of wire.
Tenneco Automotive Operating Company Inc.


06/25/15
20150176081 

Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments


Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (egfr) targeting treatment. The detection of these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug..
Dana-farber Cancer Institute, Inc.


06/25/15
20150176065 

Detection of pna clamping


This invention provides methods and systems for detecting sequence variants in a sample nucleic acid. Methods include pna clamping/pcr using primers with binding moieties followed by capture and detection of amplicons on a solid support.

06/25/15
20150176061 

Method for screening reagents used in pcr assays


The present invention relates to methods for screening of reagents used in the performance of polymerase chain reaction (pcr) assays. The invention has applications for genotyping, pathogen detection and in vitro diagnostics..
Roche Molecular Systems, Inc.


06/25/15
20150176060 

Method for coding of multiple pcr reactions for assay recognition


The present invention provides for methods and compositions that use fluorescent dyes for the identification of reagents and solutions that are used to perform pcr assays.. .
Roche Molecular Systems, Inc.


06/25/15
20150176056 

Electrospun fibers for protein stabliziation and storage


An electrospinning approach is disclosed for generating a dissolvable formulation of a reagent of interest in a nanoscale fiber medium. In one embodiment, the nanoscale fibers can incorporate and stabilize biological agents of interest, such as for storage at room temperature for extended periods.
General Electric Comapny


06/25/15
20150176054 

Determining analyte concentration from variant concentration distribution in measurable species


A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time.
Bayer Healthcare Llc


06/25/15
20150176049 

Determining usability of analytical test strip


A system for determining usability of an analytical test strip includes a sample chamber to receive a fluid sample, a reagent in the sample chamber having a moisture-varying impedance, and two detection electrodes contacting the reagent. A test meter applies an ac waveform across the reagent via the detection electrodes while measuring an impedance of the reagent.
Cilag Gmbh International


06/25/15
20150175812 

Antimicrobial coatings


The disclosure provides polymers having antimicrobial activity and articles with the polymers coated thereon. The polymers include a first pendant group comprising a first quaternary ammonium component, a second pendant group comprising a nonpolar component, and a third pendant group comprising an organosilane component.
3m Innovative Properties Company


06/25/15
20150175725 

Magnetic particle-polymer hybrid materials with functionalized polymers derived from norbornenyl reagents


A magnetic particle-polymer hybrid material can include: a substance having a structure of formula 1 or derivative or salt thereof: z(l-fp)m (formula 1), wherein: z is a magnetic particle smaller than 1 mm; m is a positive integer and defines the number of (l-fp) coupled to the z; l is a linker linked to the magnetic particle; fp is a functionalized polymer having: a first structure derived from a first norbornene compound linked to the magnetic particle through the l; and one or more monomeric units each including a second structure derived from a second norbornene compound, where one of the monomeric units is linked to the first structure through a saturated or unsaturated alkyl, each monomeric unit includes a functional group capable of binding with another substance.. .
The University Of Kansas


06/25/15
20150175718 

Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells


A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound.
University Of Maryland, College Park


06/25/15
20150175714 

Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells


A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound.
University Of Maryland, College Park


06/25/15
20150175681 

Antibodies for the treatment of clostridium difficile-associated infection and disease


Provided herein are reagents, compositions, and therapies with which to treat clostridium difficile infection and related disease conditions and pathologies, such as clostridium difficile-associated diarrhea, resulting from infection by clostridium difficile bacteria and the enterotoxins produced by these bacteria. In particular, antibodies or antigen-binding fragments thereof that bind specifically to toxin a and/or toxin b of c difficile and neutralize the activities of these toxins; compositions comprising such antibodies; and methods of using the antibodies and the compositions are provided..
Progenics Pharmaceuticals, Inc.


06/25/15
20150174588 

Methods for facilitating mineral extraction


There is provided methods for separating a target material from a raw material by mixing the raw material with water to form a slurry, adding a collector compound to the slurry to modify a relative hydrophobicity of a surface of the target material, adding a facilitator compound to enhance the modification of the relative hydrophobicity of the surface, and forming a froth including a concentrate of the target material. Disclosed methods may also include adding a facilitator compound to a raw material slurry that has been treated with a collector compound and a reagent for neutralizing the collector compound..
Chemtreat, Inc.


06/25/15
20150174440 

Method for mechanochemical treatment of solid wastes containing perfluorinated or polyfluorinated compounds


A method for mechanochemical treatment of solid wastes containing perfluorinated or polyfluorinated compounds is provided. It belongs to the field of environment-polluting wastes treatment, and comprises the following steps: mixing the solid waste containing perfluorinated or polyfluorinated compounds with the defluorination reagent under normal temperature and pressure conditions, putting the mixture into a planetary high-energy ball milling reactor; adopting the mechanochemical reaction to realize high-effective degradation and defluorination of perfluorinated or polyfluorinated compounds.
Tsinghua University


06/25/15
20150174260 

Amine-containing transfection reagents and methods for making and using same


There are provided for herein novel amine-containing transfection compounds and methods for making and using same. The compounds are generally obtained by reacting a primary amine with an unsaturated compound.
Life Technologies Corporation


06/25/15
20150174257 

Methods and reagents for efficient and targeted gene transfer to monocytes and macrophages


The present invention provides a biosafe and useful vector to transfer genetic material to cd14+ mononuclear cells (monocytes and monocyte-derived macrophages) in an efficient and specific manner. The embodiment of the invention makes use of the chimeric human adenovirus vectors 5 carrying the short fiber of enterotropic ad40 to transfer genetic material to the target cd14+ mononuclear cells..
Fundacio Privada Institucio Catalana De Recerca I Estudis Avancats


06/25/15
20150174202 

Methods and compositions for modulating beta cell proliferation


Methods and compositions are provided for modulating pancreatic islet β cell proliferation. Aspects of the methods include promoting β cell proliferation by providing agents that promote pdgfr signaling, or inhibiting β cell proliferation by providing agents that inhibit pdgfr signaling.
The Board Of Trustees Of The Leland Stanford Junior University


06/25/15
20150173408 

Method of producing nanofibrillar cellulose with high absorptivity to fat and cholate


The invention provides a method for making nanofibrillar cellulose with high absorptivity to fat and cholate. According to the invention, dietary fiber material is activated by steam flash explosion and hydrolyzed sequentially by xylanase, laccase and cellulase.
Jiangnan University


06/18/15
20150170900 

Apparatuses and methods for depositing sic/sicn films via cross-metathesis reactions with organometallic co-reactants


Disclosed herein are methods of forming sic/sicn film layers on surfaces of semiconductor substrates. The methods may include introducing a silicon-containing film-precursor and an organometallic ligand transfer reagent into a processing chamber, adsorbing the silicon-containing film-precursor, the organometallic ligand transfer reagent, or both onto a surface of a semiconductor substrate under conditions whereby either or both form an adsorption-limited layer, and reacting the silicon-containing film-precursor with the organometallic ligand transfer reagent, after either or both have formed the adsorption-limited layer.
Novellus Systems, Inc.


06/18/15
20150168430 

Trapping reagents for reactive metabolites screening


The present invention provides compounds of formula (i) and (ii): (i) (ii) wherein r1, r2, r4, r5, r6, x and n are as defined herein, and wherein r3 is hydrogen or a sulfur protecting group. Compounds of formula (i) and (ii), wherein r is hydrogen, may be useful in methods for detecting a reactive metabolite in a sample, e.g., wherein the metabolite is generated from the metabolism of a test compound, and wherein the metabolite and the compound of formula (i) or (ii) react to form a detectable adduct, e.g., detectable by mass spectrometry..
Biogen Idec Ma Inc.


06/18/15
20150168427 

Quantification of lipoproteins


Some aspects of this disclosure provide methods and reagents for the detection of apolipoproteins in a sample, for example, a sample obtained from a human subject. Some aspects of this disclosure provide protocols and reagents for the quantification of lipoproteins and lipoprotein particle populations comprising specific combinations of non-integral apolipoproteins and integral apolipoproteins, which is useful, inter alia, for the detection of diseases such as cardiovascular disease as well as an assessment of the risk of an individual to develop a disease..
President And Fellows Of Harvard College A Non-profit Corporation


06/18/15
20150168425 

Method and agents to quantify proteins from tissues


As described herein, a robust generalizable method to accurately and sensitively quantitate proteins in tissues and fluids from human patients in a direct manner, not reliant on antibody reagents has been developed. This provides new and robust methods that are useful as biochemical outcome measures in human clinical trials.
Agada Biosciences, Llc


06/18/15
20150168423 

Cardiovascular risk event prediction and uses thereof


The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the evaluation of risk of a caradiovascular (cv) event within 5 years. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to evaluate risk of a cv event within 5 years.
Somalogic, Inc.


06/18/15
20150168414 

Methods and compositions for personalized medicine by point-of-care devices for fsh, lh, hcg and bnp


The present invention relates to biomarkers, methods, devices, reagent, systems and kits for the detection, diagnosis of ovarian cancer as well as for the monitoring of ovarian cancer progression and for monitoring the progress of various cancer treatments including ovarian cancer. The present invention also relates to point-of-care testing (poct) and methods for determining concentrations of biomarkers in a subject..

06/18/15
20150168397 

Device for determining at least one analyte capable of being contained in a liquid sample


A device for determining the presence and/or amount of at least one analyte contained in a liquid sample, includes a capillary diffusion element (2) materialized on which are a zone (3) for depositing the liquid sample, an upstream release zone (4) and at least two capture zones (5). The device (1) also includes at least one downstream release zone (6) located downstream of at least one of the capture zones, which downstream release zone (6) includes at least one detection reagent conjugated to a visible and/or measurable marker; and the detection reagent of a release zone and/or the capture reagent of the additional capture zone(s), located directly downstream of the release zone, are suitable for binding specifically with the analyte and/or for binding specifically with one another, in order to form a complex that enables the determination of the analyte in the liquid sample at the additional capture zone(s)..

06/18/15
20150168395 

In vitro diagnostic tool, membrane for in vitro diagnostic tool, and production methods of the tool and the membrane


Provided is an in vitro diagnostic tool configured to quantitatively or qualitatively detect a suspected substance in a test solution, the tool including: a first porous layer having a first surface and a second surface; a base sheet bonded to the first surface; a second porous layer bonded to the second surface; and a reagent configured to react with the suspected substance and carried in at least a part of the second porous layer, wherein: the first porous layer has a matrix structure of first nanofibers formed by electrostatic spinning; the second porous layer has a matrix structure of second nanofibers formed by electrostatic spinning; and a fiber diameter of the second nanofibers is smaller than a fiber diameter of the first nanofibers.. .
Panasonic Intellectual Property Management Co. Ltd


06/18/15
20150168388 

Multiplexed analyses of test samples


The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule.
Somalogic, Inc.


06/18/15
20150168387 

Color-produing diagnostic systems, reagents and methods


Provided herein are novel reagents and their use in color-producing detection systems for performing diagnostic tests and analytical assays.. .
Diagnostic Innovations, Llc


06/18/15
20150168382 

Methods and reagents for evaluating the binding of mammalian sperm


The present invention provides a new apparatus/system for determining fertility of mammalian sperm based on a specific sperm-binding test that mimics sperm binding to an egg. The inventive apparatus/system comprises surface-modified beads with a compound or conjugates containing a carbohydrate sequence associated with the mammalian zona-pellucida (zp) glycoproteins..
The Curators Of The University Of Missouri


06/18/15
20150168373 

Analytical device for determining a digestion parameter of a liquid sample


An analytical device for determining a parameter of a liquid sample, especially a digestion parameter, such as chemical oxygen demand, total carbon content or total nitrogen content, comprising a reactor, and measuring system for ascertaining the parameter of the liquid sample. A container system for storing samples, reagents and waste products in containers, a transport and dosing system for metering and transporting the sample and reagents from the containers into a metering container and for disposal of waste products from the metering container into a waste container, and a measuring transducer for registering a measured parameter correlating, measured value of the liquid sample mixed in the reactor, and measuring, system, in given cases, with one or more reagents is provided.
Endress + Hauser Conducta Gesellschaft Für Mess- Und Regeltechnik Mbh + Co. Kg


06/18/15
20150168361 

Reagent kit, assay method, microfluidic device, and assay apparatus


An assay method enhances reliability of assay of a target material by removing interfering influence of non-target materials through controlling the concentration of the target material in a sample. A reagent kit, a microfluidic device, and a test apparatus are disclosed.
Samsung Electronics Co., Ltd.


06/18/15
20150168334 

Biosensor strip


A biosensor strip includes a strip body, a working electrode and a chemical reagent layer, wherein the strip body has a conductive portion and a reaction channel. The partial wall that forms the reaction channel is a partial or an entire surface layer of the conductive portion.
Bionime Corporation


06/18/15
20150168294 

Analyte monitoring systems and methods


A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam.
Optiscan Biomedical Corporation




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