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Reagent patents



      
           
This page is updated frequently with new Reagent-related patent applications. Subscribe to the Reagent RSS feed to automatically get the update: related Reagent RSS feeds. RSS updates for this page: Reagent RSS RSS


Date/App# patent app List of recent Reagent-related patents
09/25/14
20140288854
 Analysis assisting method, analyzer, remote computer, data analyzing method, program, and reagent container patent thumbnailnew patent Analysis assisting method, analyzer, remote computer, data analyzing method, program, and reagent container
In an analysis system having an analysis apparatus using a reagent container having a memory to store reagent information concerning the reagent in the reagent container and a remote computer, the following steps are executed: reading out the reagent information from the memory of the reagent container; judging, based on the read reagent information, whether or not the reagent in the reagent container is usable; when it is judged that the reagent in the reagent container is unusable, writing data representing the reagent is unusable into the memory of the reagent container; and when it is judged that the reagent in the reagent container is unusable, registering the data representing the reagent is unusable, into a reagent database managed by the remote computer in association with identification information to identify the reagent container. Thus, it is possible to automatically identify the reagent, which should not be used, and to manage the reagent not so as to use it for the analysis.
09/25/14
20140288266
 Synthesis of cyclosporin analogs patent thumbnailnew patent Synthesis of cyclosporin analogs
The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine a. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives.
09/25/14
20140288148
 Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina) patent thumbnailnew patent Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina)
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (sina), short interfering rna (sirna), double-stranded rna (dsrna), micro-rna (mirna), and short hairpin rna (shrna) molecules capable of mediating rna interference (rnai) against target nucleic acid sequences.
09/25/14
20140287525
 Reagent container pack patent thumbnailnew patent Reagent container pack
A reagent container pack for storing, preserving, and automatically unsealing and resealing a plurality of reagent containers in a reagent container pack on-board an automated clinical sample analyzer for analyzing analytes in a body fluid.. .
09/25/14
20140287520
 System and method for optical detection using capillary action patent thumbnailnew patent System and method for optical detection using capillary action
A system and method for the detection of one or more analytes in a collected sample employs capillary action in a sample card containing a sample substrate, at least one test capsule and an absorbent pad. The absorbent pad absorbs the contents of the test capsule and delivers the same to the sample substrate, with the contents of the test capsule chemically reacting with at least one detection reagent to establish an optical indicator for the analyte(s).
09/25/14
20140287444
 Method of lipid assay and reagent for use therein patent thumbnailnew patent Method of lipid assay and reagent for use therein
A method of lipid assay characterized by assaying the lipids contained in a blood component in the presence of an organic silicon compound. The method can cause specific conditions for direct methods while satisfying requirements such as no influence on precision of assay, no burden on assay apparatus, and easy availability..
09/25/14
20140287440
 Melittin peptide conjugates and methods employing same patent thumbnailnew patent Melittin peptide conjugates and methods employing same
Methods and reagents are disclosed for conducting assays for ige specific for honey bee venom allergen. A reagent comprises a conjugate of a small molecule linked to a terminal glycine amino acid of a synthetic 26 amino acid melittin peptide.
09/25/14
20140286962
 Reagents and methods for detecting pnh type ii white blood cells and their identification as risk factors for thrombotic disorders patent thumbnailnew patent Reagents and methods for detecting pnh type ii white blood cells and their identification as risk factors for thrombotic disorders
The disclosure relates to methods for detecting pnh type ii cell populations in biological samples as well as methods for determining whether a patient is at an increased risk for developing thrombocytopenia or thrombosis based on the percentage of pnh type ii cells in the patient's blood. The disclosure also features reagents and conjugates for use in the methods..
09/25/14
20140286932
 Giant obscurins and uses thereof in cancer prognosis and therapy patent thumbnailnew patent Giant obscurins and uses thereof in cancer prognosis and therapy
Provided herein are methods and kits for evaluating potential for invasiveness, metastasis, or recurrence of an epithelial cell cancer. In the methods the expression profile of giant obscurins is detected in a tissue sample of tumor cells or suspected tumor cells and assessed for giant obscuring expression level and distribution therein.
09/25/14
20140286838
 Apparatus for automated processing biological samples patent thumbnailnew patent Apparatus for automated processing biological samples
The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.. .
09/25/14
20140286825
new patent Test strip for measuring biological fluid
The invention relates to a test strip. The test strip comprises an insulating sheet; a metallic circuit layer disposed on the insulating sheet, the metallic circuit layer including at least an electrode section; a sensing reagent layer provided on the electrode section; an intermediate layer disposed to cover the insulating sheet and the metallic circuit layer, the intermediate layer having an opening to expose the sensing reagent layer and the electrode section; and a cover disposed to cover the intermediate layer and the insulating sheet, and expose part of the metallic circuit layer, the cover having two holes corresponding to the opening.
09/25/14
20140286124
new patent Automated reagent manager of a diagnostic analyzer system
A reagent manager for a diagnostic analyzer system includes a reagent manager housing, a high-speed reagent bottle spinning device, a processor, and a memory. The reagent manager housing is for housing reagent bottles.
09/25/14
20140284304
new patent Method of fabricating test strip of biological fluid
The invention provides a method of fabricating test strips for measuring biological blood. The method comprises steps: preparing an insulating membrane material; printing a metallic circuit layer on the insulating membrane material by a metallic ionic ink; performing a surface treatment for the metallic circuit layer expose metallic ions of the metallic ionic ink; chemical plating for the exposed metallic ions of the metallic circuit layer to form an electrode section on the metallic circuit layer; providing a sensing reagent on the electrode section to form a sensing reagent layer; sequentially adhering an intermediate layer and a cover to the insulating membrane material to cover the metallic circuit layer and expose part of the metallic circuit layer; and cutting the insulating membrane material to form a plurality of insulating sheets.
09/25/14
20140284204
new patent Method and device for ionizing particles of a sample gas glow
A device for ionizing particles (molecules or clusters) of a sample gas flow comprises a first flow tube for providing the sample gas flow, and a generator for producing reagent primary ions from particles of candidate reagent gas flow at a primary ion production region. The device also has an interaction region for introducing the reagent ions into the sample gas flow in order to arrange interaction between the reagent primary ions and the particles of the sample gas flow, thereby producing sample gas ions to be delivered to a detector.
09/18/14
20140276577
Thermochemical reaction ablation catheter
Embodiments disclosed herein are directed to devices, methods, and systems for the treatment of tissue using energy delivery. Specifically, certain embodiments may utilize a thermochemical reaction between at least two reagents where a first reagent has been preloaded into a catheter while a limiting reagent is circulated through the catheter to react with the first reagent.
09/18/14
20140276356
Novel enhanced device and composition for local drug delivery
A medical device for delivering a reagent, such as a pharmaceutical agent, a diagnostic agent, a nutrient, or another type of reagent, to an intravascular or intralumenal location, is disclosed. The medical device has a coating, where exposing the coating to light severs a photosensitive bond that releases the reagent into the immediate vicinity of the location..
09/18/14
20140276196
System and method for allergy testing
An allergy testing device is formed by a blister pack containing a series of collapsible chambers each associated with an allergen and a lancet. The allergy testing device may be placed adjacent to a patient's skin and actuated by applying pressure to the collapsible chambers to open the chambers and release the reagents contained therein.
09/18/14
20140275656
(z,z,e)-1-chloro-6,10,12-pentadecatriene and method for preparing (z,z,e)-7,11,13-hexadecatrienal by using same
Provided are (z,z,e)-1-chloro-6,10,12-pentadecatriene that can be synthesized without an oxidation reaction and a method for preparing (z,z,e)-7,11,13-hexadecatienal by using (z,z,e)-1-chloro-6,10,12-pentadecatriene while not using an oxidation reaction. More specifically, provided is a method for preparing (z,z,e)-7,11,13-hexadecatrienal including a step of reacting a grignard reagent into which (z,z,e)-1-chloro-6,10,12-pentadecatriene is converted with ethyl orthoformate to obtain (z,z,e)-1,1-diethoxy-7,11,13-hexadecatriene, and a step of treating the (z,z,e)-1,1-diethoxy-7,11,13-hexadecatriene with an acid to obtain (z,z,e)-7,11,13-hexadecatrienal..
09/18/14
20140275482
Novel benzophenone-based chromophoric crosslinkers and reagents for incorporation of biotin or other haptens into macromolecules
Compounds for uv-vis detectable incorporation of a crosslinker a hapten into a protein or macromolecules are disclosed. The compounds comprise bis heterofunctional crosslinkers or haptens containing a chromophoric group that is incorporated into the linker that is positioned between a reactive linking moiety and a biotin molecule.
09/18/14
20140275481
Solid phase peptide synthesis processes and associated systems
Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support.
09/18/14
20140275434
Silicone-containing contact lens having reduced amount of silicon on the surface
The present invention relates to a method of reducing the amount of silicon on a surface of a contact lens, wherein the method includes reacting the surface of a contact lens containing at least one silicone component with a fluoride reagent.. .
09/18/14
20140275432
Methods for the selective sequestration of alkyne-presenting molecules and related compositions and methods
Provided herein are methods for sequestering an alkyne-presenting molecule in a sample and related sequestration reagents, compositions, methods and systems.. .
09/18/14
20140274805
Multi-array, multi-specific electrochemiluminescence testing
Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest.
09/18/14
20140274784
Automated immunoanalyzer system for performing diagnostic assays for allergies and autoimmune diseases
A quantitative method for performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.. .
09/18/14
20140274782
Affinity reagents and methods for detection, purification, and proteomic analysis of methylated proteins
Methyl-lysine affinity reagents created by engineering the 3×mbt methyl-lysine binding domain repeat of lethal (3) malignant brain tumor-like protein 1 (l3mbtl1) are disclosed. In particular, the invention relates to affinity reagents and affinity chromatography media comprising the 3×mbt domain repeat and methods of using such affinity reagents in detection, purification, and proteomic profiling of methylated proteins and peptides..
09/18/14
20140274776
Porphyrin-modified antimicrobial peptides for application as indicators of microbial targets
Porphyrin-modified antimicrobial peptides as described here may be used as indicators of the presence of microbial targets. Their application may be as (for example) (1) fluorescent indicators in a microarray format, (2) fluorescence or absorbance based indicators in traditional solution based applications, or (3) reflectance based indicators for use in reagent-less detection platforms..
09/18/14
20140274770
Pcr assays and reagents for molecular detection of infectious agents
The present disclosure is directed to pcr-based assays and compositions for use in molecular detection of viral, bacterial and parasitic infectious agents in body fluid or tissue samples, and in particular to multiplex assays, as well as to solid reagent compositions for use in such assays.. .
09/18/14
20140273526
Atomic layer deposition of films comprising si(c)n using hydrazine, azide and/or silyl amine derivatives
Provided are methods for the deposition of films comprising si(c)n via atomic layer deposition processes. The methods include exposure of a substrate surface to a silicon precursor and a co-reagent comprising a compound selected from the group consisting of n═n═n—r, r2n—nr2, and (r3si)qnh3-q, wherein q has a value of between 1 and 3, and each r is independently selected from organosilicons, c1-c6 substituted or un-substituted alkanes, branched or un-branched alkanes, substituted or un-substituted alkenes, branched or un-branched alkenes, substituted or un-substituted alkynes, branched or un-branched alkynes or substituted or un-substituted aromatics..
09/18/14
20140273521
Photoresist system and method
A system and method for photoresists is provided. In an embodiment a cross-linking or coupling reagent is included within a photoresist composition.
09/18/14
20140273492
Methods of etching films comprising transition metals
Provided are methods for etching films comprising transition metals. Certain methods involve activating a substrate surface comprising at least one transition metal, wherein activation of the substrate surface comprises exposing the substrate surface to heat, a plasma, an oxidizing environment, or a halide transfer agent to provide an activated substrate surface; and exposing the activated substrate surface to a reagent comprising a lewis base or pi acid to provide a vapor phase coordination complex comprising one or more atoms of the transition metal coordinated to one or more ligands from the reagent.
09/18/14
20140273275
Biomarkers for liver fibrosis
Methods and systems for diagnosing or prognosing liver fibrosis in a subject are provided. In some examples, such methods and systems can include detecting liver fibrosis-related molecules in a sample obtained from the subject, comparing expression of the molecules in the sample to controls representing expression values expected in a subject who does not have liver fibrosis or who has non-progressing fibrosis, and diagnosing or prognosing liver fibrosis in the subject when differential expression of the molecules between the sample and the controls is detected.
09/18/14
20140273274
Methods for the selective detection of alkyne-presenting molecules and related compositions and systems
Provided herein are methods for selectively detecting an alkyne-presenting molecule in a sample and related detection reagents, compositions, methods and systems.. .
09/18/14
20140273268
Preparation of samples for analysis
An apparatus for preparation of samples for analysis comprising includes structure (21) for interchangeably locating first racks of sample receptacles that contain samples to be prepared for analysis and second racks include racks of different configuration racks for of sample receptacles which second that are respectively transferable to different analysis instruments, and for receiving and positioning a plurality of reagent vessels at known respective positions. An assembly of devices (50,60) is actuable to transfer samples from sample receptacles of the first rack to sample receptacles of the second rack, while carrying out a sample preparation operation selected from a plurality of pre-programmed sample preparation operations, wherein the apparatus is configured to identify which of said the second racks of different configuration is located at said the structure, and to adapt said the transfer and said the selected sample preparation operation to suit the identified rack.
09/18/14
20140273250
Methods for the selective detection of alkyne-presenting molecules and related compositions and systems
Provided herein are methods for selectively detecting an alkyne-presenting molecule in a sample and related detection reagents, compositions, methods and systems.. .
09/18/14
20140273249
High range activated clotting time assay formulation
High range activated clotting time (hr-act) tests detect blood clotting time in blood samples which have high levels of heparin. Reagents such as calcium chloride and kaolin within the test apparatus trigger clotting.
09/18/14
20140273243
Water hardness monitoring via fluorescence
Provided are automated methods for measuring soluble magnesium concentration in water using fluorescence. The methods employ the use of a ph-buffered liquid and a magnesium coordinating fluorescing reagent.
09/18/14
20140273187
Point of care sensor systems
Provided are point of care sensor systems that include portable readers and disposable cartridges for receiving and analyzing samples. A cartridge may be equipped with one or more sensor channels, each containing one or more sensors.
09/18/14
20140273078
Apparatus for working on histological samples
The invention relates to an apparatus for treatment of histological samples. The apparatus includes at least a working station, in which the sample gets into contact with a liquid reagent.
09/18/14
20140273061
Reagents, systems and methods for analyzing erythrocytes and platelets
Aspects of the invention include hematology analysis reagents, systems and methods that can be used to preserve blood cell morphology and integrity as well as provide sample integrity and optical clarity to facilitate optical analysis of blood samples. In some embodiments, the reagents include a non-phosphate organic buffer and a sphering surfactant.
09/18/14
20140273060
Reagents, systems and methods for analyzing white blood cells
Aspects of the invention include wbc analysis reagents, systems and methods that can be used for analyzing a sample of whole blood to identify, classify, and/or quantify white blood cells (wbc) and wbc sub-populations in the sample. The wbc analysis reagents of the present disclosure generally include at least one membrane-permeable fluorescent dye, a wbc protecting reagent, and a surfactant.
09/18/14
20140273056
Device and method for extracting a targeted fraction from a sample
A device and a method for isolating a target from a sample are provided. The target is bound to solid phase substrate to form a target bound solid phase substrate.
09/18/14
20140273052
Chemical sensing apparatus having multiple immobilized reagents
A sensor system in a water treatment system has a housing, controller, one or more light sources, one or more sensors and one or more targets having an immobilized reagent thereon. Light source emits light energy into the housing that is incident upon the target with the immobilized reagent and the reagent being in contact with water from the system.
09/18/14
20140273051
Chemical sensing apparatus having multiple immobilized reagents
An apparatus sensing two or more reactants or analytes in a sample is provided. The apparatus has an one or more light sources emitting energy with two or more detection targets having an immobilized reagent within the target surface.
09/18/14
20140273040
Method for producing recombinant prothrombin, vector dna, and reagent kit
The present invention provides a method for producing recombinant prothrombin. The method comprises: providing a vector dna into which a gene encoding a tag and a gene encoding prothrombin are incorporated, wherein the tag is selected from the group consisting of mbp, sumo, and nusa; and expressing a tag fusion type prothrombin in a lepidopteran insect or cultured cells of the lepidopteran insect..
09/18/14
20140273034
Electrochemical methods and devices for amending urine samples for immunosensor detection
The present invention is directed to methods and devices for amending undiluted and partially diluted urine samples in a manner suitable for performing immunoassays for target analytes, for example ngal. Generally, the urine sample is treated with reagents including at least one of buffer materials, water soluble proteins, urease, and other interferent mitigants.
09/18/14
20140273014
Electrochemical methods and devices for amending urine samples for immunosensor detection
The present invention is directed to methods and devices for amending undiluted and partially diluted urine samples in a manner suitable for performing immunoassays for target analytes, for example ngal. Generally, the urine sample is treated with reagents including at least one of buffer materials, water soluble proteins, urease, and other interferent mitigants.
09/18/14
20140273004
Molecules and methods for iterative polypeptide analysis and processing
Reagents and methods for the digital analysis of proteins or peptides are provided. Specifically provided herein are proteins for identifying the n-terminal amino acid or n-terminal phosphorylated amino acid of a polypeptide.
09/18/14
20140272994
Methods and reagents that specifically detect, distinguish and quantify ifn-lambda2 mrna from ifn-lambda3 mrna in humans
The present invention provides a method of specifically detecting ifn-λ2 mrna or ifn-λ3 mrna. There is provided a qrt-pcr method specifically detecting, discriminating and quantifying ifn-λ2 and ifn-λ3 mrna in a biological sample obtained from a human.
09/18/14
20140272989
Reagent wells containing lyophilized reagents
System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle..
09/18/14
20140272961
Methods and compositions for detecting mutations in the human pi3kca (pik3ca) gene
The invention comprises reagents and methods for detecting cancer-associated mutations in the human pi3kca (pik3ca) gene and assessing the patients based thereon.. .
09/18/14
20140272943
Rapid and highly fieldable viral diagnostic
The present invention relates to a rapid, highly fieldable, nearly reagentless diagnostic to identify active rna viral replication in a live, infected cells, and more particularly in leukocytes and tissue samples (including biopsies and nasal swabs) using an array of a plurality of vertically-aligned nanostructures that impale the cells and introduce a dna reporter construct that is expressed and amplified in the presence of active viral replication.. .
09/18/14
20140272933
Hcv antigen-antibody combination assay and methods and compositions for use therein
The present invention generally relates to combination immunoassays, reagents and kits for simultaneous detection of hcv antigens and anti-hcv antibodies in a test sample.. .
09/18/14
20140272932
Hcv ns3 recombinant antigens and mutants thereof for improved antibody detection
The present disclosure relates to polypeptides, including fusions thereof, nucleic acids, vectors, host cells, immunodiagnostic reagents, kits, and immunoassays for use detecting the presence of hcv antibodies. More specifically, the present invention describes specific ns3 antigens that can be used for the detection of anti-hcv antibodies..
09/18/14
20140272921
Methods and reagents for maintaining the viability of cancer cells in surgically removed tissue
A composition and method for generating reagents and the composition of these reagents for the stabilization and preservation of viability of cancer tissue which has been surgically excised and the suspension and/or termination of apoptosis (cell death) by significant modulation of cell metabolism by low molar concentrations of synergistic chemistries and hormonal growth enhancers while maintaining normal gene expression patterns of the surgically excised tissue.. .
09/18/14
20140271672
Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
09/18/14
20140271569
Kits and methods for processing stem cells from bone marrow or umbilical cord blood
Provided herein are kits for processing stem cells from bone marrow or umbilical cord blood, comprising: a) a precipitation reagent comprising an aqueous solution of 0.1-30% hydroxyethyl starch or 0.1-30% methyl cellulose, and 0.1-20% of cerebroprotein hydrolysate; and b) a separation reagent comprising an aqueous solution comprising ficoll and diatrizoate and having a density of 1.0-1.2 g/ml, and methods of use. Further provided herein is a collection of stem cells obtained by the kits and methods disclosed herein comprising stem cells from bone marrow or umbilical cord blood, and uses thereof..
09/18/14
20140271409
Fluid cartridge
System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle..
09/18/14
20140271403
Closure system for reagent vessel receiving positions in an automatic analysis apparatus
The invention relates to a closure system for a holder for a reaction vessel in an automatic analysis apparatus. The closure system comprises a lid secured movably on a retainer element, wherein the lid closes an opening of the holder in a closed position and opens it in an open position.
09/18/14
20140271402
Fluidics system for sequential delivery of reagents
The invention provides a passive fluidics circuit for directing different fluids to a common volume, such as a reaction chamber or flow cell, without intermixing or cross contamination. The direction and rate of flow through junctions, nodes and passages of the fluidics circuit are controlled by the states of upstream valves (e.g.
09/18/14
20140271368
Device for performing an assay
This invention relates to a device for performing an assay to detect an analyte in a fluid sample comprising a channel with reagent deposits comprising a flow control reagent positioned at one or more defined locations therein and a method for producing such a device. In particular, the invention relates to a microfluidic device..
09/18/14
20140271360
Multi-well tray and rack therefor
System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle..
09/18/14
20140271359
Automated analyzer
Stepped portions of a flow channel are reduced by completely fixing the channel that extends to the measuring unit, and reducing connections in the channel, thereby to suppress a disturbance in the flow of the liquid suctioned into the measuring unit. A means is provided so that the reaction solution and reagent suctioned will move towards the channel through which the liquids are suctioned..


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