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Reagent patents



      
           
This page is updated frequently with new Reagent-related patent applications. Subscribe to the Reagent RSS feed to automatically get the update: related Reagent RSS feeds. RSS updates for this page: Reagent RSS RSS


Method and system for measuring pyruvate

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Method and system for measuring pyruvate

Date/App# patent app List of recent Reagent-related patents
04/23/15
20150112630
 Method for calibrating clinical chemistry instruments patent thumbnailnew patent Method for calibrating clinical chemistry instruments
A method of deriving correction for instrument-to-instrument variations in the illumination band centroid wavelengths and wavelength band shapes of the optical systems of clinical chemistry instruments includes the steps of determining the centroid wavelength and wavelength band shape of a light source used in the optical system of a clinical chemistry instrument to provide a determined wavelength band shape and centroid wavelength, comparing the determined wavelength band shape and centroid wavelength with a known reflection density or absorbance wavelength spectrum of a specific type of chemical reagent test to provide a correction value, and calculating the correction value, which is to be used to modify a reflection density or absorbance measurement taken by the instrument of a reagent test of the a specific type of chemical reagent test.. .
Idexx Laboratories, Inc.
04/23/15
20150112175
 Method and system for measuring urea patent thumbnailnew patent Method and system for measuring urea
A body-mountable urea sensing device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent localized near the working electrode that selectively reacts with urea.
Google Inc.
04/23/15
20150112173
 Method and system for measuring pyruvate patent thumbnailnew patent Method and system for measuring pyruvate
A body-mountable pyruvate sensing device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent localized near the working electrode that selectively reacts with pyruvate.
Google Inc.
04/23/15
20150112067
 Process for making cgrp receptor antagonists patent thumbnailnew patent Process for making cgrp receptor antagonists
The disclosure encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, having less steps and improved yields as compared to previous synthetic methods for making these compounds, which are cgrp receptor antagonists, useful for the treatment of migraine. Conditions for an amide bond formation between an acid and amine include for example reacting the compounds of formulae b (after salt break) and c with an amide coupling reagent and optionally an additive and an acid and/or a base in a non-reactive solvent..
Merck Sharp & Dohme
04/23/15
20150112054
 Method for isolating and purifying rna from biological materials patent thumbnailnew patent Method for isolating and purifying rna from biological materials
Includes the following steps: (1) mix organs and tissues with formamide and monovalent cation salt solution, homogenize them to obtain the dehydrated biological sample; (2) mix the dehydrated biological sample with monovalent cation salt solution for incubation; (3) add the monovalent cation salt solution with precipitation effect to the mixture, mix them and centrifuge, then pour the supernatant into another centrifuge tube; (4) add isopropanol, mix it and centrifuge, and then discard the upper phase liquid, the lower phase liquid and the visible residual impurities between the upper and lower phases to get white rna precipitate. This method proposed in the invention enables efficient isolation of protein from rna in the biological samples.
Tianjin Spring Tide Biotech Co., Ltd.
04/23/15
20150111967
 Method for making a peroxycarboxylic acid patent thumbnailnew patent Method for making a peroxycarboxylic acid
The present invention relates to apparatus and methods for making a peroxycarboxylic acid. The apparatus includes a reaction catalyst and a guard column for pretreating one or more reagents, which can increase the life, activity, and/or safety of the reaction catalyst.
Ecolab Usa Inc.
04/23/15
20150111784
 Detecting cells secreting a protein of interest patent thumbnailnew patent Detecting cells secreting a protein of interest
In some cases, the described systems and methods include obtaining a cell sample containing multiple antibody-producing cells. In such cases, the cells can be tagged with a cross-linking reagent having a first portion configured to bind to a marker on the antibody-producing cells and a second portion configured to bind to an antigen of interest.
Berkeley Lights, Inc.
04/23/15
20150111775
 Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof patent thumbnailnew patent Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual having a cardiovascular disorder to treatment of the disorder with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
Celera Corporation
04/23/15
20150111773
 Rapid affinity measurement of peptide ligands and reagents therefor patent thumbnailnew patent Rapid affinity measurement of peptide ligands and reagents therefor
The present invention provides methods for rapidly screening and measuring the ligand binding affinity of in vitro selected peptides to the cognate and off-target proteins. This general strategy is amenable to high throughput analysis because the peptides are synthesized by cell-free translation, as opposed to solid-phase synthesis required by traditional assays, and affinities can be readily measured in standard formats..
04/23/15
20150111765
 Biocoated piezoelectric biosensor platform for point-of-care diagnostic use patent thumbnailnew patent Biocoated piezoelectric biosensor platform for point-of-care diagnostic use
Biosensor components (chips) are described based on direct biocoating processes that result in the tenacious and stable, noncovalent (believed to be chemisorptive) binding of anchor substances such as avidin(s) other proteins having specific binding partners or oligo- or poly-nucleotides onto any piezo-electrically active crystal surface. The resulting platform technology can be developed for a variety of biosensors with specific applications in biological assays.
Aviana Molecular Technologies, Llc.
04/23/15
20150111307
new patent

Organic colored microparticles, diagnostic reagent kit containing the same, and in vitro diagnosis method


Provided are an immunochromatography kit that is highly sensitive and capable of multicoloration, and organic colored microparticles that are ideal as an element of the immunochromatography kit. Organic colored microparticles having an average grain size between 10 and 1,000 nm and a color intensity between 1.0 and 5.0 are prepared using cellulose as the starting material.
Asahi Kasei Fibers Corporation
04/23/15
20150111297
new patent

Apparatus and processing microscopic single cell biological specimens with a single microtool


An oocyte and embryo-positioning apparatus enables a plurality of oocytes, embryos or other cell specimens to be held and positioned for injection therein of fluid molecular reagents such as dna, rna, protein, cells, spermatozoa and cells; and removal of cells, fragments of cells, cytoplasm, nuclei and cellular organelles. The oocytes and embryos are kept separate from each other in open marked or unmarked well-compartments that are located in the culture container.
04/23/15
20150111215
new patent

Sample handling


The invention provides containers and methods of use for the storage, transportation and preparation of samples, such as dna samples for analysis. The container is pre-provided with the reagents in sealed chambers.
Forensic Science Service Limited
04/23/15
20150111202
new patent

Automated staining system and reaction chamber


An apparatus including a reagent cartridge and a reaction chamber, the reagent cartridge having a reagent capsule removably positioned therein for dispensing of a reagent onto the reaction chamber. A system including a linearly translatable mounting assembly having a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge, a linearly translatable bulk reagent dispensing assembly having a plurality of bulk reagent dispensing nozzles coupled thereto and a receiving assembly positioned beneath the mounting assembly and the bulk reagent dispensing assembly, the receiving assembly including a plurality of reaction stations.
Sakura Finetek U.s.a., Inc.
04/23/15
20150111147
new patent

Sustainable polyester resin of defined acid value


The disclosure describes a process for making a polyester resin of defined acid value using a temperature-sensitive reaction and dipropylene glycol as a reagent.. .
Xerox Corporation
04/23/15
20150110890
new patent

Bone marrow aspirate enhanced bone graft


A method of preparing a bone graft. Mixing bone marrow aspirate with an effective amount of a binding reagent that is capable of binding with red blood cells in the bone marrow aspirate.
Fortus Medical, Inc.
04/23/15
20150110676
new patent

Optical sensor element for analyte assay in a biological fluid, and manufacture thereof


Beginning with a sheet of optically transparent material, one may fabricate a great many shaped optical wafers, each in the form of a thin and essentially flat piece of optical material having a narrow cross-sectional width relative to length, and a sharply narrowed tip at one end. The fabrication process involves passing a sheet of optically transparent material through one or more operational steps wherein cutting, shearing, embossing, microperforating, or a combination thereof is performed.
Light Pointe Medical, Inc.
04/23/15
20150107413
new patent

Methods for fabrication of nanostructures


Systems and methods for fabricating nanostructures using other nanostructures as templates. A method includes mixing a dispersion and a reagent solution.
Nthdegree Technologies Worldwide Inc.
04/16/15
20150105475

Point of use generation of amyl nitrite


The present disclosure relates to devices and methods for the preparation of amyl nitrite formulations at a point of use location from relatively shelf-stable reagents employing acidic cationic exchange resins.. .
Southwest Research Institute
04/16/15
20150105445

Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina)


The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (sina), short interfering rna (sirna), double-stranded rna (dsrna), micro-rna (mirna), and short hairpin rna (shrna) molecules capable of mediating rna interference (rnai) against target nucleic acid sequences.
Sirna Therapeutics, Inc.
04/16/15
20150105300

Sample processing methods


A method of processing a sample may include introducing a sample into a vessel, the vessel having proximal and distal ends, the sample being introduced into the proximal end of the vessel; incubating the sample in the vessel with a substance capable of specific binding to a preselected component of the sample; propelling components of the incubated sample, other than the preselected component, toward the proximal end of the vessel by clamping the vessel distal to the incubated sample and compressing the vessel where the incubated sample is contained; propelling the preselected component toward a distal segment of the vessel by clamping the vessel proximal to the preselected component and compressing the vessel where the preselected component is contained; and mixing the preselected component with a reagent in the distal segment of the vessel.. .
Iquum, Inc.
04/16/15
20150104876

Release reagent for vitamin d compounds


The present invention concerns a reagent composition for releasing vitamin d compounds bound to vitamin d-binding protein, a method for the detection of a 25-hydroxyvitamin d compound in which the 25-hydroxyvitamin d compound is released from vitamin d-binding protein using this reagent and the mixture obtained in this manner is analyzed, the use of the reagent to release vitamin d compounds as well as a kit for detecting 25-hydroxyvitamin d which contains the reagent for releasing vitamin d compounds in addition to the usual immunological reagents.. .
Roche Diagnostics Operations, Inc.
04/16/15
20150104792

Portable fluorimetric apparatus, method and system


A fluorimetric system, apparatus and method are disclosed to measure an analyte concentration in a sample. A sensor reagent housing is also disclosed which comprises a channel and a porous medium having an analysis chemistry reagent, such as a nucleic acid analysis chemistry reagent.
Andalyze, Inc.
04/16/15
20150104784

Magnetic and/or electric label assisted detection system and method


A detection system (100) is described for detecting analytes in a fluid sample. The detection system (100) comprises a transporting means (6) for transporting magnetic and/or electric labels (5) after interaction between the sample fluid and the reagents towards a detection receptacle (1).
Koninklijke Philips N.v.
04/16/15
20150104561

Method of screen printing on a substrate


A test sensor reagent for measuring the concentration of analytes in body fluids includes cellulose polymers for improving the stability of the test sensor and reducing the total assay time. The test sensor reagent also includes an enzyme, an electron transfer mediator and a rheological additive..
Bayer Healthcare Llc
04/16/15
20150104382

Compositions and methods for identifying and targeting cancer cells of alimentary canal origin


Screening and diagnostic reagents, kits and methods for primary and or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or metastatic stomach or esophageal cancer are disclosed.
Thomas Jefferson University
04/16/15
20150104363

Reagent doser diagnostic system and method


Systems and methods are disclosed for determining or diagnosing a reagent dosing system failure to provide sufficient reagent to an exhaust aftertreatment system that includes an scr catalyst to satisfy a reagent dosing command.. .
Cummins Emission Solutions Inc.
04/16/15
20150104351

Automatic analyzer


A high-throughput automatic analyzer integrates a biochemical analysis section and a blood coagulation analysis section. The analyzer is capable of achieving a reduction in size, system cost, and lifecycle cost.
Hitachi High-technologies Corporation
04/16/15
20150101929

Reagent composition for redox reaction


The present invention relates to a stabilizing composition useful for improving the stability of reagent for redox reaction, and a reagent composition for redox reaction having an improved stability. The reagent composition for redox reaction can be applied for a reagent for electrochemical biosensor..
I-sens, Inc.
04/09/15
20150099893

Reagent for enhancing generation of chemical species


A reagent that enhances acid generation of a photoacid generator and composition containing such a reagent is described.. .
Toyo Gosei Co., Ltd.
04/09/15
20150099870

Glycosylation reactions using phenyl(trifluoroethyl)iodonium salts


Comprising the step of combining r′—oh, a glycosyl sulfide glycosyl donor (“thioglycoside donor”), a hypervalent iodine alkyl-transfer activating reagent, and a base. In an embodiment, the hypervalent iodine alkyl-transfer activating reagent is (phenyl(trifluoroethyl)iodonium triflimide)..
04/09/15
20150099747

Methods and compositions for detecting mutation in the human ezh2 gene


The invention comprises reagents and methods for detecting cancer-associated mutations in the human ezh2 gene. Further, a method of detecting the mutations and a method of treatment are disclosed..
Roche Molecular Systems, Inc.
04/09/15
20150099659

Multiplex probes


Methods and reagents suitable for conducing polymerase chain reaction are described. In particular, the disclosure provides probes and primers that are suitable in dynamic flux amplification procedures.
Fluoresentric, Inc
04/09/15
20150099307

Glucose test strip authentication using ink


A method of authenticating includes providing a glucose test strip having a top surface with a reagent thereon that has a structure which chemically reacts with glucose and an anti-counterfeiting identification feature (identification feature) including at least one ink. The glucose test strip is inserted into a glucose meter.
Texas Instruments Incorporaated
04/09/15
20150099305

Detection of protein s-sulfhydration via a tag-switch technique


Methods and assays for detecting s-sulfhydration of amino acids in proteins, polypeptides and peptides are provided. The method is a two-step “tag-switch” method employing two reagents consecutively to specifically label, with a detectable label, persulfide (—s—sh) linkages in proteins, polypeptides and peptides..
Washington State University
04/09/15
20150099263

Selective detection of human rhinovirus


A process for detecting human rhinovirus nucleic acid in a biological sample, includes producing an amplification product by amplifying an human bocavirus nucleotide sequence using a forward primer of seq id no: 1, and a reverse primer of seq id no: 2, and measuring said amplification product to detect human rhinovirus in said biological sample. Also provided are reagents and methods for detecting and distinguishing human rhinovirus from other viruses.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
04/09/15
20150099183

Electrodes and electrochemical cells employing metal nanoparticles synthesized via a novel reagent


Electrodes employing as active material metal nanoparticles synthesized by a novel route are provided. The nanoparticle synthesis is facile and reproducible, and provides metal nanoparticles of very small dimension and high purity for a wide range of metals.
Toyota Motor Engineering & Manufacturing North America, Inc.
04/09/15
20150099182

Metal nanoparticles synthesized via a novel reagent and application to electrochemical devices


Methods for synthesizing metal nanoparticles and the nanoparticles so produced are provided. The methods include addition of surfactant to a novel reagent complex between zero-valent metal and a hydride.
Toyota Motor Engineering & Manufacturing North America, Inc.
04/09/15
20150099172

Synthesis of metal nanoparticles


Methods for synthesizing metal nanoparticles and the nanoparticles so produced are provided. The methods include addition of surfactant to a novel reagent complex between zero-valent metal and a hydride.
Toyota Motor Engineering & Manufacturing North America, Inc.
04/09/15
20150099135

Magnesium ion batteries and magnesium electrodes employing magnesium nanoparticles synthesized via a novel reagent


Electrodes employing as active material magnesium nanoparticles synthesized by a novel route are provided. The nanoparticle synthesis is facile and reproducible, and provides magnesium nanoparticles of very small dimension and high purity for a wide range of metals.
Toyota Motor Engineering & Manufacturing North America, Inc.
04/09/15
20150099117

Synthesis of metal alloy nanoparticles via a new reagent


Methods for producing nanoparticles of metal alloys and the nanoparticles so produced are provided. The methods include addition of surfactant and cationic metal to a novel reagent complex between zero-valent metal and a hydride.
Toyota Motor Engineering & Manufacturing North America, Inc.
04/09/15
20150098892

Stable complexes of zero-valent metal and hydride as novel reagents


A composition and its method of production are provided. The composition includes at least one zero-valent metal atom in complex with at least one hydride molecule.
Toyota Motor Engineering & Manufacturing North America, Inc.
04/09/15
20150098886

Stable complexes of non-metal elements and hydride as novel reagents


A reagent and its method of production are provided. The reagent includes at least one zero-valent atom, whether metal, metalloid, or non-metal, in complex with at least one hydride molecule.
Toyota Motor Engineering & Manufacturing North America, Inc.
04/09/15
20150098885

Stable complexes of zero-valent metallic element and hydride as novel reagents


A composition and its method of production are provided. The composition includes at least one zero-valent metallic element atom in complex with at least one hydride molecule.
Toyota Motor Engineering & Manufacturing North America, Inc.
04/09/15
20150098884

Stable complexes of multiple zero-valent metals and hydride as novel reagents


A composition and its method of production are provided. The composition includes at least one zero-valent metal atom in complex with at least one hydride molecule.
Toyota Motor Engineering & Manufacturing North America, Inc.
04/09/15
20150098882

Stable complexes of zero-valent metallic element and hydride as novel reagents


A composition and its method of production are provided. The composition includes at least one zero-valent metallic element atom in complex with at least one hydride molecule.
Toyota Motor Engineering & Manufacturing North America, Inc.
04/09/15
20150098877

Circulating dry scrubber system and method


A system and method suitable for the removal of pollutants from gases with a circulating dry scrubber system having a circulating dry scrubber reactor containing a fluidized bed adapted to contact the gas with a dry reagent within the fluidized bed. The system includes a housing fluidically coupled to the reactor, a filter array within the housing, and an internal hopper within the housing and adapted to return at least some of the particulates to the fluidized bed within the circulating dry scrubber reactor.
Marsulex Environmental Technologies Corporation
04/09/15
20150098876

Process for the joint production of sodium carbonate and sodium bicarbonate


Process for the joint production of sodium carbonate and sodium bicarbonate crystals, according to which: a solid powder derived from sodium sesquicarbonate, having a mean particle diameter comprised between 0.1 and 10 mm is dissolved in water; the resulting water solution is introduced into a crystallizer, wherein a first water suspension comprising sodium carbonate crystals is produced; the first water suspension is subjected to a separation, in order to produce crystals comprising sodium carbonate on the one hand, which are valorized, and a mother liquor on the other hand; and a part of the mother liquor is taken out of the crystallizer and put into contact in, a gas liquid contactor, with a gas comprising carbon dioxide, in order to produce a second water suspension comprising sodium bicarbonate crystals, which are separated and valorized. A reagent powder comprising sodium bicarbonate crystals made by such process..
Solvay Sa
04/09/15
20150098873

Test cassette


A test cassette applicable to an optical reading device capable of reading identification codes includes a test sheet with a supporting layer and a reactive reagent layer; a case for retaining the test sheet; and an identification code situated on a surface of the case for recording a test item and a test standard value of the test cassette.. .
04/09/15
20150098866

Light guide test sensor


An optic light guide test sensor comprises a light guide, a reagent-coated membrane, and a mesh layer. The reagent-coated membrane and the mesh layer are attached to the light guide at an output end of the light guide.
Bayer Healthcare Llc
04/09/15
20150097649

Ferromagnetic carbon and boron lithium borohydride complexes


A novel ferromagnetic composition is provided. The reagent includes at least one zero-valent atom, whether metal, metalloid, or non-metal, in complex with at least one hydride molecule.
Toyota Motor Engineering & Manufacturing North America, Inc.
04/09/15
20150097114

Excitation of reagent molecules withn a rf confined ion guide or ion trap to perform ion molecule, ion radical or ion-ion interaction experiments


A mass spectrometer is disclosed comprising an rf ion guide or ion trap and a device arranged and adapted to supply a reagent gas within the rf ion guide or ion trap. The mass spectrometer further comprises a photo-ionisation device and a control system arranged and adapted: (i) to cause first ions to fragment or dissociate within the rf ion guide or ion trap to form second ions and neutral molecules; and (ii) to cause the photo-ionisation device to photo-ionise and/or photo-excite the reagent gas to form reagent ions, excited species or radical species.
Micromass Uk Limited
04/02/15
20150094460

High purity heparin and production method therefor


The present invention provides a high purity heparin useful to be a pharmaceutical product, cosmetics, research reagent, or the like, and a method for producing the same, more specifically, a heparin which does not substantially contain a nitrous acid degradation-resistant impurity and a method for producing a heparin, comprising mixing an aqueous solution of 5 to 30% by weight of the heparin with ethanol having an amount (volume) 0.2 to 1 times the amount (volume) of the aqueous heparin solution to obtain a colloidal precipitate of heparin.. .
Fuso Pharmaceuticals Industries, Ltd.
04/02/15
20150094451

Readily isolated bispecific binding molecules with native format having mutated constant regions


The invention provides heterodimer bispecific antigen-binding molecules that include a first polypeptide that does not include an igg ch1 domain and a second polypeptide having an immunoglobulin constant region where there is at least one mutation in the igg ch3 domain that abolishes the ability of the second polypeptide to bind ch3-specific affinity media such that the first and second polypeptides have different affinities with respect to ch1 and ch3 specific affinity reagents that allows rapid isolation by differential binding of the first and second polypeptides to these affinity reagents. The invention also provides bispecific antibodies that have igg ch1 and ch3 regions with different affinities with respect to affinity reagents that allows rapid isolation by differential binding of the igg regions to these affinity reagents.
Novimmune S.a.
04/02/15
20150094238

Reagent bead inserter


A system for inserting reagent or macrobeads into bores of a sample plate is disclosed comprising an insertion device arranged to retain one or more reagent or macrobeads by means of a vacuum whilst inserting the reagent or macrobeads into bores of the sample plate.. .
Dynex Technologies, Inc.
04/02/15
20150094222

Quantitative multiplex methylation specific pcr method- cmethdna, reagents, and its use


The cmethdna method of the present invention is a novel modification of the qm-msp method (u.s. Pat.
The Johns Hopkins University
04/02/15
20150094196

Chamber component for a reagent vessel, and use thereof


A revolver component for a reagent vessel has at least one first chamber that is configured to be filled at least partly with at least one liquid. The first chamber is formed or fitted such that a first chamber filling volume that is configured to be filled with the at least one liquid is delimited by an expansion-variable boundary.
Robert Bosch Gmbh
04/02/15
20150093834

Supply module for an automated analyzer


A method is described for supplying consumables to an automated analyzer by providing at least one reagent and at least one solid consumable from a supply module which is docked to the analyzer, followed by undocking the supply module from the analyzer and removing it therefrom. Also described is a respective system and a supply module for supplying consumables to an automated analyzer..
Roche Molecular Systems, Inc.
04/02/15
20150093788

Methods and reagents for molecular cloning


The present invention provides compositions, methods, and kits for covalently linking nucleic acid molecules. The methods include a strand invasion step, and the compositions and kits are useful for performing such methods.
Life Technologies Corporation
04/02/15
20150093771

Microfluidic analytical device for analysis of chemical or biological samples, method and system thereof


An analytical device for analysis of chemical or biological samples, a method of using such a device, based on rotation of the device, integrated sample dosing and optical detection, and a system comprising such a device are disclosed. The analytical device comprises a device body having a liquid processing unit.
Roche Diagnostics Operations, Inc.
04/02/15
20150093766

Diagnostic reagents


There is provided a diagnostic reagent useful to determine whether an animal has a tuberculosis infection or has been exposed to a tuberculosis agent, for example a mycobacterium. The reagent is useful to distinguish between such an animal and an animal which has been vaccinated against a tuberculosis infection..
The Secretary Of State For Environment, Food & Rural Affairs
04/02/15
20150093764

Blocking reagent compositions and methods of making and using the same


Blocking reagent compositions, as well as methods of making and using the same, are provided. Aspects of the composition include a blocking reagent that binds to the cell surface but does not specifically bind to a targeted first cell surface antigen.
Becton, Dickinson And Company
04/02/15
20150093405

Influenza a virus vaccines and inhibitors


The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (cpsf30) binding site on the surface of the influenza a non-structural protein 1 (ns1). Specifically, critical biochemical reagents, conditions for crystallization and nmr analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza a (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development..
Rutgers, The State University Of New Jersey
04/02/15
20150093397

Methods for increasing efficacy of cd37-based therapy


Methods to improve the success of cancer therapies that target cd37 are provided. Kits comprising reagent useful in the methods are further provided..
Immunogen, Inc.
04/02/15
20150093315

Tunable aig for improved scr performance


A system for controlling reagent flow to an exhaust of a lean burn combustion source includes a plurality of decomposition ducts each being connected to at least one injection lance of a reagent injection grid and supplying reagent and hot carrier gas to the injection lance, and at least one metering valve in communication with each of the plurality of decomposition ducts that controls reagent injection rate to the injection lance. A method of controlling a reagent flow to an exhaust of a lean burn combustion source includes providing a reagent injection grid having at least one injection lance, supplying the reagent and hot carrier gas to the reagent injection grid from a plurality of decomposition ducts coupled to the injection grid, and controlling reagent injection rate to the injection grid via at least one metering valve in communication with each of the plurality of decomposition ducts..
04/02/15
20150090808

Coaxial flow injector


An injector for injecting a reagent includes an axially translatable valve member positioned within a housing. An electromagnet is positioned within the housing and includes a coil of wire positioned proximate the valve member such that the valve member moves between a seated position and an unseated position relative to an orifice in response to energizing the electromagnet.
Tenneco Automotive Operating Company Inc.
03/26/15
20150087967

Method and apparatus using magnetic resonance imaging for tissue phenotyping and monitoring


Provided herein is a magnetic resonance imaging (mri) technique and, optionally, software, collectively referred to as the “shutter-speed” model, to analyze image data of cancer patients. Embodiments provide a minimally invasive, yet precisely accurate, approach to determining whether tumors are malignant or benign by distinguishing the characteristics of contrast reagent activity in benign and malignant tumors.
Brigham And Women's Hospital
03/26/15
20150087868

Apparatus and synthesizing f-18 labeled radioactive pharmaceuticals


The present invention relates to an apparatus for synthesizing f-18 labeled radioactive pharmaceutical. The apparatus for synthesizing f-18 labeled radioactive pharmaceutical includes an f-18 radioactive isotope supplier, a reagent supplier, a polymer precursor cartridge, a first heating unit, a polymer compound cartridge, a synthesizing container, a second heating unit, a water liquid container, a transmitting gas supplier, a cleansing liquid supplier, a connection tube, a plurality of control valves, and a controller..
Sogang University Research Foundation
03/26/15
20150087718

Compositions and methods relating to dennd1a variant 2 and polycystic ovary syndrome


Provided are compositions and methods for use in polycystic ovary syndrome diagnosis (pcos). The method involves a sample from a subject for a dennd1a variant 2 mrna or dennd1 a variant 2 protein to make or aid in a diagnosis of pcos.
Virginia Commonwealth University
03/26/15
20150087550

Apparatus and methods for parallel processing of micro-volume liquid reactions


Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate.
The Board Of Trustees Of The Leland Stanford Junior University
03/26/15
20150087541

Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cells


The present invention is based in part on a chemically defined method of generating neural stem cells (nscs) and dopaminergic (da) neurons from human pluripotent stem cells (hpscs). The da neurons of the invention can be derived from hpscs and nscs.
International Stem Cell Corporation
03/26/15
20150087532

Affinity reagents for protein purification


Disclosed herein are methods and compositions for purifying proteins from crude solutions.. .
The Board Of Trustees Of The Leland Stanford Junior University
03/26/15
20150087530

Low-volume sequencing system and use


Various embodiments of a low-volume sequencing system are provided herein. The system can include a low-volume flowcell having at least one reaction chamber of a defined volume (e.g., less than about 100 μl).
Life Technologies Corporation
03/26/15
20150087075

Sulphur detection method and kit


Method of detecting the presence of sulphur in a construction material such as asphalt or concrete comprising the steps of:·(a) adding a quantity of the construction material to a solvent to form a test solution, wherein the solvent is capable of solubilising all or part of any sulphur which is present in the construction material and wherein the solvent is miscible with an aqueous solution; and·(b) detecting the presence of sulphur in the test solution by (i) adding to the solution a reagent which induces part or all of any sulphur present in the test solution to precipitate and (ii) measuring the turbidity of the test solution after the precipitation has been formed. The present invention further relates to a sulphur detection kit for detecting the presence of sulphur in construction materials such as asphalt or concrete..
Shell Oil Company
03/26/15
20150087005

Phosphorothioate oligonucleotide-labeling of white blood cells


The present invention provides labeling and capture reagents that comprise phosphorothioate oligonucleotides odn). The ps-odn bind to all white blood cells (leukocytes) in an indiscriminative fashion and enable the labeling, capture, or concentration of leukocytes in a manner that preserves the antigenic integrity of the cells.
Becton, Dickinson And Company


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