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Reagent patents



      
           
This page is updated frequently with new Reagent-related patent applications. Subscribe to the Reagent RSS feed to automatically get the update: related Reagent RSS feeds. RSS updates for this page: Reagent RSS RSS


Kit for immuno-chromatography, reagent for immuno-chromatography, and method of detecting using them

Date/App# patent app List of recent Reagent-related patents
08/28/14
20140243555
 Method for the synthesis of 18f-labelled molecules patent thumbnailnew patent Method for the synthesis of 18f-labelled molecules
The present invention provides a method for the synthesis of 18f-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention.
08/28/14
20140243527
 Purification methods for betulonic acid and boc-lysinated betulonic acid, and organic synthesis of betulonic acid amides with piperazine derivatives patent thumbnailnew patent Purification methods for betulonic acid and boc-lysinated betulonic acid, and organic synthesis of betulonic acid amides with piperazine derivatives
The present invention provides a method of purifying betulonic acid contained the reaction product of organic synthesis of a jones oxidation reagent and betulin extracted from the bark of a birch, a method of preparing a piperazine betulonic acid amide derivative, which is used as a chemical having an antibacterial function, using the high-purity betulonic acid obtained by the purification method and a derivative prepared by this method, a method of purifying a boc-lysinated betulonic acid monomer ester contained in the reaction product of organic synthesis of lysine and the high-purity betulonic acid (starting material) obtained by the purification method, and a method of purifying boc-lysinated betulonic acid contained in the reaction product of hydrolysis of the high-purity boc-lysinated betulonic acid monomer ester.. .
08/28/14
20140243517
 Methods of producing c-aryl glucoside sglt2 inhibitors patent thumbnailnew patent Methods of producing c-aryl glucoside sglt2 inhibitors
Method for the production of c-aryl glucoside sglt2 inhibitors useful for the treatment of diabetes and related diseases. And intermediates thereof.
08/28/14
20140243429
 Enzyme-degradable polymer and application thereof patent thumbnailnew patent Enzyme-degradable polymer and application thereof
The present invention belongs to the biomedicine field and specifically concerns an enzyme-degradable polymer and the application thereof. To solve the problem of low sensitivity of the existing assay reagents, the present invention provides an enzyme-degradable polymer and the related application of the polymer.
08/28/14
20140243404
 Unique halogen-induced cyclizations, reagents therefor, and compounds produced thereby patent thumbnailnew patent Unique halogen-induced cyclizations, reagents therefor, and compounds produced thereby
This disclosure is related to halonium compounds useful for cyclization of polyenes, alkenoic acids, and alkenyl alkyl ethers, and halogenation of aromatic compounds. The synthesis of such halonium compounds, compounds made using such halonium compounds, and synthesis of natural compounds, including decalins, using the halonium compounds is also disclosed.
08/28/14
20140242813
 Low k precursors providing superior integration attributes patent thumbnailnew patent Low k precursors providing superior integration attributes
A deposition for producing a porous organosilica glass film comprising: introducing into a vacuum chamber gaseous reagents including one precursor of an organosilane or an organosiloxane, and a porogen distinct from the precursor, wherein the porogen is aromatic in nature; applying energy to the gaseous reagents in the chamber to induce reaction of the gaseous reagents to deposit a film, containing the porogen; and removing substantially all of the organic material by uv radiation to provide the porous film with pores and a dielectric constant less than 2.6.. .
08/28/14
20140242720
 Kit for immuno-chromatography, reagent for immuno-chromatography, and method of detecting using them patent thumbnailnew patent Kit for immuno-chromatography, reagent for immuno-chromatography, and method of detecting using them
A kit for immunochromatography, having: a planar test strip having a test area and a reference area, the test area having a test purpose capturing substance, the reference area having a reference purpose capturing substance; fluorescent particulates provided with a binding property to a target substance, the target substance provided with a binding property to the test purpose capturing substance; and light absorbing particulates provided with a binding property to the reference purpose capturing substance.. .
08/28/14
20140242718
 Pretreatment device and method for biochemical reaction patent thumbnailnew patent Pretreatment device and method for biochemical reaction
A pretreatment device applied in sampling and providing a reaction space for biochemical reaction is disclosed. The pretreatment device includes a quantitative sampler being capable of collecting a constant volume of a sample; a devastating device having a hollow cylindrical structure coupled to the quantitative sampler to damage a thin-film like protective membrane of the quantitative sampler such that the reaction reagent flows out of the reagent container; a reaction device having a tubular structure and providing the reaction space for biochemical reaction of the reaction reagent and the sample; a hollow ring-shaped structure to position and stable the connection of the devastating device and the quantitative sampler with the hollow ring-shaped structure being coupled to the reaction device; and an anti-drain device preventing the reaction reagent and the sampler from flowing out before the biochemical reaction is completed..
08/28/14
20140242716
 Specimen cup and method patent thumbnailnew patent Specimen cup and method
A specimen collection cup has a container. The container has a wall and a floor and is configured for receiving and retaining a specimen.
08/28/14
20140242709
 Rapid fluorescence tagging of glycans and other biomolecules with enhanced ms signals patent thumbnailnew patent Rapid fluorescence tagging of glycans and other biomolecules with enhanced ms signals
Reagents comprising ms active, fluorescent molecules with an activated functionality for reaction with amines useful in tagging biomolecules such as n-glycans and uses thereof are taught and described.. .
08/28/14
20140242683
new patent Apparatus for selective excitation of microparticles
Nucleic acid microparticles are sequenced by performing a sequencing reaction on the microparticles using one or more reagents, selectively exciting the microparticles in an excitation pattern, optically imaging the microparticles at a resolution insufficient to resolve individual microparticles, and processing the optical images of the microparticles using information on the excitation pattern to determine the presence or absence of the optical signature, which indicates the sequence information of the nucleic acid. An apparatus for optical excitation of the microparticles comprises an interference pattern generation module that splits a first laser beam into second and third laser beams and generates the excitation pattern for selectively exciting the microparticles by interference between the second and third laser beams..
08/28/14
20140242647
new patent In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes
The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product.
08/28/14
20140242634
new patent Methods and compositions for hematoxylin and eosin staining
The present invention provide for solutions of a defined composition useful in a staining protocol, such as a hematoxylin and eosin staining protocol, when used at certain points of the staining protocol. The formulations of these defined solutions are such that carry-over of the solutions will not negatively impact, or preferably, will stabilize or favorably modify staining reagent solutions coming in contact with the solutions.
08/28/14
20140242615
new patent Methods and reagents for determining isomeric analytes
Methods include determining in a sample an amount of a first isomeric analyte and a second isomeric analyte. A first measurement value and a second measurement value are determined.
08/28/14
20140242584
new patent Genomic dna extraction reagent and method
The present invention is directed to a genomic dna extraction reagent and method for improved extraction of dna from biological tissue. The extraction reagent of the invention is mixed with disrupted biological tissue to form a dna extraction solute which is incubated in a dna extraction step.
08/28/14
20140241946
new patent Open platform automated sample processing system
An automated sample processing system having a sample input adapted to simultaneously receive a number of sample containers, a reagent input adapted to receive one or more new reagent supplies, a consumable input adapted to receive one or more new consumable supplies, a solid waste output adapted to receive used consumable supplies, a liquid waste output adapted to receive one or more used reagent supplies, and a processing center. The processing center includes a decapper adapted to remove a lid from at least one sample container, an aspirator adapted to remove a specimen from the at least one sample container and transfer the specimen to an output vessel, and a capper adapted to replace the lid on the at least one sample container.
08/28/14
20140238950
new patent Container connector
A connector cap for a reagent bottle which can be pre-attached to a fully assembled synthesis cassette allows greater control in the assembly of the cassette and simpler operation for the end user. The connector cap may be incorporated onto reagent bottle or on vials to be used with automated synthesis cassettes..
08/28/14
20140238833
new patent Fused metal nanostructured networks, fusing solutions with reducing agents and methods for forming metal networks
Reduction/oxidation reagents have been found to be effective to chemically cure a sparse metal nanowire film into a fused metal nanostructured network through evidently a ripening type process. The resulting fused network can provide desirable low sheet resistances while maintaining good optical transparency.
08/21/14
20140235970
Assembly for determining the presence or absence of an analyte in a blood sample and analysis unit comprising such an assembly
This assembly includes: a transportable support; a strip attached to the support and including an application area for applying the sample and at least one reagent required for the analysis; a piercing member for piercing the skin and a blood vessel; and a container for collecting, storing and returning the sample of human or animal blood. The piercing member is inserted into the container.
08/21/14
20140235881
Method for producing 5-hydroxymethyl-2-furfural or alkyl ether derivatives thereof using an ion exchange resin in the presence of an organic solvent
The present invention relates to a method for producing a furan-based compound using an ion exchange resin in the presence of an organic solvent. In the method for producing a furan-based compound according to the present invention, a furan-based compound is made from an aldose-type hexose compound in the presence of an organic solvent by using an anion exchange resin and a cation exchange resin.
08/21/14
20140235866
Process to obtain a trifluoromethylating composition
Process to obtain a trifluoromethylating composition which comprises the reaction between a copper (i) source and a base in the presence of a solvent and between the resulting cuprating reagent with fluoroform.. .
08/21/14
20140235861
Method for the synthesis of 18f-labelled biomolecules
The present invention provides a method for the synthesis of 18f-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention.
08/21/14
20140235838
Selective aerobic alcohol oxidation method for conversion of lignin into simple aromatic compounds
Described is a method to oxidize lignin or lignin sub-units. The method includes oxidation of secondary benzylic alcohol in the lignin or lignin sub-unit to a corresponding ketone in the presence of unprotected primarily aliphatic alcohol in the lignin or lignin sub-unit.
08/21/14
20140235833
Method of classifying antibody, method of identifying antigen, method of obtaining antibody or antibody set, method of constructing antibody panel and antibody or antibody set and use of the same
The present invention relates to an isolated antibody against her1, an isolated antibody against cd147, an isolated antibody against cd73, and an isolated antibody against epcam; reagents and compositions including said antibodies; and uses of said reagents, compositions, and antibodies. The present invention also relates to nucleic acids and vectors expressing said antibodies.
08/21/14
20140235605
Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment, particularly for reducing the risk of cardiovascular disease, especially coronary heart disease (such as myocardial infarction) and stroke. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents and kits for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents and kits for their detection..
08/21/14
20140234979
Rapid protein labeling and analysis
The present invention provides methods and compositions for labeling, separating and analyzing proteins, particularly a specific protein of interest within a cell lysate or in a mixture of proteins. The proteins are labeled with an amine reactive or thiol reactive fluorescent dye, or an amine reactive fluorogenic reagent that becomes fluorescent upon reacting to amine groups located on the protein.
08/21/14
20140234881
Lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same
Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region..
08/21/14
20140234874
Compositions and methods for in vitro diagnostic tests including sulfonic acid
The invention provides compositions, kits, and methods for performing colorimetric analysis. A substrate is reacted to generate a chromogenic reaction product, and a reaction stop reagent that is a sulfonic acid is added to stop and stabilize the reaction product.
08/21/14
20140234830
Direct amplification and detection of viral and bacterial pathogens
Provided are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids. Further provided are reagent mixtures that allow for direct amplification of a sample, without the step of nucleic acid extraction..
08/21/14
20140234533
Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same
The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low action on maltose. The present invention relates to a polynucleotide encoding a soluble coenzyme-linked glucose dehydrogenase that catalyzes the oxidation of glucose in the presence of an electron acceptor and has an activity toward maltose of 5% or lower; a polypeptide encoded by the nucleotide sequence of the polynucleotide; a recombinant vector carrying the polynucleotide; a transformed cell produced using the recombinant vector; a method for producing a polypeptide comprising culturing the transformed cell and collecting from the cultivated products a polypeptide that links to fad to exert the glucose dehydration activity; a method for determination of glucose using the polypeptide; a reagent composition for determination of glucose; and a biosensor..
08/21/14
20140234338
Therapeutic agent for use in a method of treating psoriasis or atopic dermatitis
The present invention provides a therapeutic agent for psoriasis or atopic dermatitis, and comprises anti-staphylococcus aureus antibodies as the active ingredient. A therapeutic agent for psoriasis or atopic dermatitis is specifically provided.
08/21/14
20140234335
Method and reagent for diagnosis and/or evaulation of progression of graft-versus-host disease
Disclosed is a method of diagnosing graft-versus-host disease, comprising measuring the level of ccl8 protein in a sample obtained from a subject as an indicator for the diagnosis or course of graft-versus-host disease. Also a diagnostic reagent for graft-versus-host disease comprising an anti-ccl8 antibody is disclosed.
08/21/14
20140234291
Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with rheumatoid arthritis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
08/21/14
20140234185
Reagent container
A test reagent container includes: a bottom part; a peripheral wall part on the periphery of the bottom part; a storage part which opens upward and with an internal diameter of an inner peripheral wall decreased with depth; a film which seals the opening of the storage part; a discharge channel which penetratingly passes from an inner bottom surface of the storage part to the bottom part of the container body; a projecting part formed downwardly projecting from the bottom part to seal an outlet of the discharge channel; a breakable part including a thick-walled part and a thin-walled part thinner than the thick-walled part formed on the periphery of the projecting part. The breakable part is broken when the projecting part is depressed from outside of the container, the projecting part is inserted into the inside of the discharge channel, and the sealed state of the outlet is released..
08/21/14
20140234181
System for managing inventory of bulk liquids
A system for managing bulk liquids for an automated clinical analyzer. The system comprises (a) at least one local reservoir for storing a bulk liquid for impending use, (b) at least one container for holding a bulk liquid before the liquid is transferred to a local reservoir, and (c) a controller for monitoring the level of a bulk liquid in a local reservoir.
08/21/14
20140232029
Kit for measuring the thrombin generation in a sample of a patient's blood or plasma
The invention provides a kit for measuring the thrombin generation in a sample of a patient's blood or plasma, or in a sample of clotting factors. The kit contains lyophilized tissue factor/phospholipid-complex and a lyophilized mixture containing a thrombin-substrate and cacl2.
08/21/14
20140231271
Process for metal reduction of hydrocarbon oil
A novel process for metal content reduction of hydrocarbon oil is disclosed, which is primarily aimed at reduction of vanadium and nickel. The process uses electricity to accelerate the demetallation process, but only the flow of electrons of the electric current is used to expedite the reaction, instead of the electrolysis effect of the electric current.
08/21/14
20140230517
Quality control reagents and methods
The present invention provides reagents for instrumentation quality control and methods of use thereof. In particular, sets of peptides or other molecules are provided for evaluating the performance of instruments with mass spectrometry (ms) and/or liquid chromatography (lc) functionalities..
08/21/14
20140230267
Sludge drying composite conditioner and application method thereof
Provided is a sludge drying composite conditioner. The sludge drying composite conditioner comprises a fenton's reagent or/and fenton-like reagent and a matrix construct, the weight ratio between the fenton's reagent or/and the fenton-like reagent and the matrix construct is 1:0.05 to 300, and the matrix construct is powder.
08/14/14
20140228601
Methods for recovering chlorinated hydrocarbons
Processes for isolating 1,1,1,2,3-pentachloropropane from a crude product stream containing the 1,1,1,2,3-pentachloropropane and ferric chloride. The processes may include deep distillation of the crude, treatment of the crude with a reagent that deactivates the ferric chloride followed by distillation on the deactivated crude stream, aqueous washing of the crude product stream to remove ferric chloride followed by distillation on the deactivated crude stream.
08/14/14
20140228597
Process for the manufacture of dihalodiphenylsulfones starting from organic acids
A process for the preparation of dihalodiphenylsulfones_such as 4,4′-dichlorodiphenyl sulfone or 4,4′-bis-(4-chlorophenylsulfonyl)biphenyl with high regioselectivity, at low temperature and in the absence of toxic reagents by reacting together at least one acid, sulfur trioxide and at least one halobenzene. The invented process is particularly suited for the manufacture of 4,4′-dichlorodiphenyl sulfone..
08/14/14
20140228516
Bispecific intracellular delivery vehicles
A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a ph-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target..
08/14/14
20140228484
Polymer, process and use
There is described a process for producing a gel free hyperbranched polyamide polymer p having a polydispersity of at least 1.1 and a weight average molecular weight of at least 300 daltons, having primary amino groups (useful as a crosslinker). The process comprises the step of reacting reagent a, a compound comprising at least one amino group (—nh2) and one functional group selected from the group consisting of a further amino group (—nh2), thiol (—sh) and a secondary amine radical (—nhr); (where r denotes a hydrocarbo group) (=functional amine) and reagent b, an alpha-beta unsaturated michael-reactive ester comprising a plurality of ester groups (=diester); in a molar ratio of amine a to diester b greater than 1 but less than 3 (preferably 2.1 to 2.9); to form the polyamide in a two stage reaction michael addition and then amidation.
08/14/14
20140228256
Method and kit for constructing plasma dna sequencing library
The disclosure relates a method and a kit for constructing a plasma deoxyribonucleic acid (dna) sequencing library. The method provided by the disclosure includes: extracting a plasma dna; making the plasma dna ligate to a sequencing linker, and purifying a ligation product; performing polymerase chain reaction (pcr) amplification for the purified ligation product, purifying the pcr amplification product, and obtaining the plasma dna sequencing library, wherein, the method does not include the step of performing 5′-terminus phosphorylation for the plasma dna.
08/14/14
20140228251
Sirna targeting catenin, beta-1 (ctnnb1)
Efficient sequence specific gene silencing is possible through the use of sirna technology. By selecting particular sirnas by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.
08/14/14
20140228244
Calibration reagent and method
The present invention relates to a method for calibrating a multiplex assay, comprising: adding a calibration reagent to a solid phase on which a plurality of capturing agents are immobilised, adding a detection molecule which has a capacity to bind to the calibration reagent, detecting bound detection molecule, thereby creating a calibration curve, wherein the calibration reagent comprises at least two different binding molecules, wherein each binding molecule has a capacity to bind specifically to a capturing agent immobilised on the solid phase and a capacity to bind to a detection molecule. Further provided is a multiplex assay system comprising such a calibration reagent..
08/14/14
20140228229
Methods for identifying and monitoring drug side effects
The present invention relates generally to methods for identifying drug side effects by detecting perturbations in organ-specific molecular blood fingerprints. The invention further relates to methods for identifying drug-specific organ-specific molecular blood fingerprints.
08/14/14
20140227800
Method for stabilizing glycerophospholipids and reagents using same
Disclosed is an accurate and stable immunoassay reagent using a glycerophospholipid and a method for stabilizing the reagent. The reagent for assaying an analyte in blood by immune reaction with an antigen when the analyte is an antibody or with an antibody when the analyte is an antigen, wherein a glycerophospholipid and a polyvinylpyrrolidone are incorporated into the immune reaction system..
08/14/14
20140227796
Devices and methods for the collection and detection of substances
The present invention provides a single self-contained device for collecting, extracting, on-site testing, and transferring for forensic confirmatory analysis, a wide variety of substances including, but not limited to, drugs of abuse, explosives, weapons of mass destruction, food toxins and industrial wastes. Samples can be obtained from a surface by swabbing a suspect area or the testing of solid materials (pills, capsules, powders), air samples and biological and non-biological fluids by placing the substance in the device.
08/14/14
20140227793
Compositions and methods for glycan sequencing
Compositions and methods directed to a glycan reagent for depolymerization of a glycan having a reducing end, the glycan reagent being represented by the formula mcx, in which m is a glycan coupling group selected from oxylamines and hydrazides; c is a fixed charge group or a basic group having a proton affinity of at least 210 kcal/mol; and x is hydrogen or a free radical initiator chemically coupled to c.. .
08/14/14
20140227770
Uses of reagents in sample collection and cartridge systems
A sample collection container and a cartridge system employ reagent bodies having reagents confined by a restraining agent. The sample collection container comprises one or more reagent bodies, each having one or more reagents confined by a restraining agent.
08/14/14
20140227721
Reagent zone deposition pattern
An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone that includes a reagent cell having a line of symmetry in the direction of fluid flow; a reagent material in the reagent cell, wherein the reagent material includes a first reagent material located at the axis of symmetry and is left-right symmetric, and a second and third reagent material having a substantially identical shape and volume and located in mirror locations from the line of symmetry; a detection zone in fluid communication with the reagent zone; and a wicking zone in fluid communication with the detection zone having a capacity to receive liquid sample flowing from the detection zone. The sample addition zone, the detection zone and the wicking zone define a fluid flow path..
08/14/14
20140227714
In situ heat induced antigen recovery and staining apparatus and method
An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another.
08/14/14
20140227707
Reagent patterning in capillarity-based analyzers and associated systems and methods
The present technology describes various embodiments of devices for processing, analyzing, detecting, measuring, and separating fluids. The devices can be used to perform these processes on a microfluidic scale, and with control over fluid and reagent transport.
08/14/14
20140227694
Epigenetic markers of pluripotency
Epigenetic methods for assessing pluripotency of a cell population, such as a stem cell culture are provided. For example, pluripotency can be assessed by determining dna methylation status at the rab25, nanog, ptpn6, mgmt, gbp3 and/or lyst gene regions.
08/14/14
20140227693
Genetic markers for risk management of atrial fibrillation, atrial flutter, and stroke
The invention relates to procedure and methods of determining a susceptibility to cardiac arrhythmia, including atrial fibrillation, atrial flutter and stroke, by assessing the presence or absence of alleles at polymorphic markers found to be associated with atrial fibrillation, atrial flutter and stroke. The invention further relates to kits encompassing reagents for assessing such markers, and diagnostic methods, uses and procedures for utilizing such susceptibility markers..
08/14/14
20140227428
Preparation method for medical porous tantalum implant material
A preparation method for medical porous tantalum implant material is provided, which includes mixing polyethylene glycol aqueous solution and tantalum powder to form tantalum slurry, casting the tantalum slurry into an organic foam body through vibrant pressurization, and going through steps of drying, degreasing, vacuum sintering and thermal treatment to obtain the porous tantalum. The solution is a 2-8 wt % polyethylene glycol aqueous solution, the frequency of vibration is 20-80 times/min, the thermal treatment is performed under 10−4-10−3 pa of vacuity and the temperature is increased to 800-900° c.
08/14/14
20140227299
Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
Where one or more nemorubicin metabolite or analog drug moieties (d) are covalently attached by a linker (l) to an antibody (ab) which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be useful in methods of diagnosis or treatment of cancer, and other diseases and disorders..
08/14/14
20140227218
Pharmaceutical compositions of conjugates formed from polymer derivatives having particular atom arrangements
Pharmaceutical compositions of conjugates are provided. The conjugates can be prepared by (among other ways) conjugating a pharmacologically active agent with a polymeric reagent that has a particular arrangement of atoms.
08/14/14
20140227146
System and method for processing biological samples
A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem including an actuation substrate, and a set of pins interacting with the actuation substrate, and a spring plate configured to bias at least one pin in a configurations, the valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; and a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols.. .
08/14/14
20140224672
Test strip, detecting device and detecting method
A test strip, a detecting device, and a detecting method are disclosed. The test strip includes a first specimen path, a first electrode set, a second specimen path, a second electrode set, and a reaction reagent.
08/14/14
20140224382
Reagent bottle cap, system, method and apparatus for handling closure caps and like
A reagent bottle includes an outer cap and an inner closing cap. The inner closing cap has a recess for gripping the cap.
08/07/14
20140221626
Compositions and methods for detection of methadone metabolite
Methods and reagents are disclosed for conducting assays for eddp. The reagents include a moiety selected from the group consisting of poly(amino acid) label moieties, non-poly(amino acid) label moieties, poly(amino acid) immunogenic carriers, non-poly(amino acid) immunogenic carriers, non-label poly(amino acid) moieties, and non-immunogenic carrier poly(amino acid) moieties linked to 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine at the 3-position of one of the phenyl rings.
08/07/14
20140221505
Methods and compositions for categorizing patients
The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in diagnostic tests, nucleic acid and amino acid sequences related to the molecular markers, reagents for detection of molecular markers, and methods for identifying candidate molecular markers in highly parallel gene expression data.. .
08/07/14
20140221484
Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
08/07/14
20140221477
Process for the preparation of a sulfated derivative of 3,5-diiodo-o-[3-iodophenyl]-l-tyrosine
The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-o-[3-iodo-4-(sulphooxy)phenyl]-l-tyrosine (t3s) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained t3s compound may conveniently be isolated in a pure form as a solid in good yields.
08/07/14
20140221433
N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
The present invention relates to an improved and shortened synthesis of n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide and the mesylate monohydrate salt thereof by using boronic acid derivatives or borolane reagents while avoiding toxic organic tin compounds and to the mesylate monohydrate salt of n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions.. .
08/07/14
20140221253
Synthetic antibodies
Methods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.. .
08/07/14
20140221224
Single tube multiplex assay for detection and quantification of adulterants in basmati rice samples
The present invention provides a single tube multiplex assay for distinguishing basmati from non-basmati rice varieties, and thereby identifying the adulteration of basmati rice varieties. The present invention further provides a method for quantifying adulteration in basmati rice varieties.
08/07/14
20140220705
Automated analyzer and analyzing method
An analyzer provides conditions suitable for a reagent for performing latex immunoassay with a high sensitivity using a method of measuring scattered light. Irradiation light having a wavelength in the range of 0.65 to 0.75 μm is used, and scattered light generated from a reaction solution is received at a light-receiving angle of 15° to 35° with respect to the irradiation direction during the rotational movement of the reaction container.
08/07/14
20140220679
Methods and compositions for categorizing patients
The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in diagnostic tests, nucleic acid and amino acid sequences related to the molecular markers, reagents for detection of molecular markers, and methods for identifying candidate molecular markers in highly parallel gene expression data.. .
08/07/14
20140220667
Device for pathogen detection
There is provided a portable device for detecting pathogens in a sample, the detection being based on an assay involving one or more reagents and heat. The device comprises a flexible substrate having a plurality of spaced apart reservoirs along its length, each reservoir adapted for receiving reagents and the sample, the substrate being secured to a pair of spaced apart reels and movable there between by rolling.
08/07/14
20140220666
Self contained in-vitro diagnostic device
A portable apparatus for measuring a glucose level of a user having: a card-like member; a processor within the card-like member; at least one glucose sensor comprising a reagent, the glucose sensor generating a signal indicative of a measured glucose level upon application of a blood sample to the glucose sensor, wherein the glucose sensor is fixed to the card-like member and operably coupled to the processor; and at least one cover alterable between a first position in which the glucose sensor is covered and a second position in which the glucose sensor is exposed for use.. .
08/07/14
20140220608
Reagentless ceria-based colorimetric sensor
A colorimetric reagent in the form of nanoparticles, composite nanoparticles, and nanoparticle coatings, including methods of use, methods of preparation, deposition, and assembly of related devices and specific applications. The colorimetric reagent comprises cerium oxide nanoparticles which are used in solution or immobilized on a solid support, either alone or in conjunction with oxidase enzymes, to form an active colorimetric component that reacts with an analyte to form a colored complex.
08/07/14
20140220600
Proteins expressed by mycobacterium tuberculosis and not by bcg and their use as diagnostic reagents and vaccines
The present invention is directed to reagents useful for generating immune responses to mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to m. Tuberculosis..
08/07/14
20140220593
Inhibition of peroxidase enzymatic activity
The present invention deals with reagents and compositions capable of effectively inhibiting peroxidase activity. According to the invention, peroxidase enzymatic activity is blocked with an acidic aqueous solution of a protein denaturing agent.
08/07/14
20140220589
Ultrasensitive detection of beta hemolytic streptococcus
The present invention is directed to a method for the ultrasensitive detection of beta hemolytic streptococcus, a bacterium implicated in strep throat, using a specific protease marker. Also disclosed is a device as well as a biosensor, both of which are useful for the detection of beta hemolytic streptococcus.
08/07/14
20140220575
Artificial selection method and reagents
The present invention provides methods for estimating the breeding value of individuals in populations such as those having small effective population size (ne) e.g., to identify selection candidates having high breeding values, wherein the methods comprise inferring one or more genotypes for one or more markers at a locus or qtl to be the same as for an ancestor or founder or a subset of ancestors and/or founders from which a corresponding chromosome segment is derived and estimating the breeding value of the individual based on the inferred genotype(s).. .
08/07/14
20140220571
Transgenic plant event detection
The present invention relates to detection of materials derived from transgenic plant events. In particular, the invention provides methods, reagents, kits and reference materials for detecting the presence or absence in a sample of genetic material derived from and attributable to select transgenic plant events..
08/07/14
20140220559
Method to determine dna mismatch repair function
This invention relates to a quantitative method for determining whether a human subject has an impaired dna mismatch repair function; providing a diagnostic sample taken from said human and producing a nuclear extract from said sample; providing mmr proficient and mmr deficient nuclear extracts as positive and negative controls, respectively; combining each nuclear extract with at least one mismatch bearing substrate dna molecule; performing a mismatch repair assay; and determining whether said sample nuclear extract is capable of repairing said substrate dna molecule; wherein said sample comprises normal, non-malignant constitutive cells, such as fibroblasts. The invention further relates to a kit providing necessary reagents for use in said method..


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