|| List of recent Reagent-related patents
|Partitioned reaction vessels|
In view of the needs of the art, the present invention provides a reaction vessel having two distinct compartments, for separating solid-supported reagents. The present invention also provides a method to perform two step radiochemistry procedures in one reactor in a clean and 10 efficient manner.
|Particle-assisted nucleic acid sequencing|
This invention generally relates to particle-assisted nucleic acid sequencing. In some embodiments, sequencing may be performed in a microfluidic device, which can offer desirable properties, for example, minimal use of reagents, facile scale-up, and/or high throughput.
|Calorimetric microfluidic sensor|
A microfluidic sensor includes a microchannel that includes a reaction site with a reagent and a sample inlet. A liquid substance is received at the sample inlet and travels by capillary action to the reaction site.
|Multiplexed detection with isotope-coded reporters|
Some aspects of this invention provide reagents and methods for the sensitive, quantitative and simultaneous detection of target analytes in complex biological samples by liquid chromatography tandem mass spectrometry (lc ms/ms). Some aspects of this invention provide affinity reagents encoded with mass reporters for the sensitive and quantitative translation of an analyte of interest into a mass tag.
|Colorectal cancer associated circulating nucleic acid biomarkers|
The invention provides methods and reagents for diagnosing colorectal cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated. In some embodiments, the cna biomarkers are polynucleotide fragments, e.g., dna fragments, that are present at an elevated level in blood, e.g., in a serum or plasma sample, of a colorectal cancer patient in comparison to the level in blood, e.g., a serum or plasma sample, obtained from a normal individual who does not have colorectal cancer..
|Fluorescent dye compounds, conjugates and uses thereof|
The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.. .
|Method and device for determining properties of gas phase bases or acids|
Properties, such as concentrations, of gas phase bases or acids of a gas sample are determined by providing a sample gas flow, which includes the bases or acids to be determined as sample constituents, as well as also interfering constituents, which are other constituents than the sample constituents. Reagent ions are provided and introduced into the sample gas flow to arrange proton transfer reaction and thereby forming sample ions.
|Blood sample assay method|
The invention provides an enzymatic method for measuring the concentration of one or more analytes in the plasma portion of a blood derived sample, containing a first and a second component, where said second component interferes with the measurement of said first component. The method includes: i) diluting the sample with a reagent mixture; ii) substantially removing blood cells; iii) using a reagent which serves to temporarily prevent reaction of the second component, to generate a blocked second component; iv) causing the selective reaction of a constituent of each analyte to directly or indirectly generate detectable reaction products, where one of the analytes is the first component; v) monitoring the detectable reaction product or products; vi) relating an amount of the detectable product or products and/or a rate of formation of the detectable product or products to the concentration of each analyte, where the concentration of at least the first component is related to a corresponding detectable reaction product by means of estimating an un-measurable (fictive) endpoint.
|Cancer stem cell-specific molecule|
An objective of the present invention is to obtain two types of substantively homogeneous cancer stem cell populations which can be characterized using the cell surface marker lgr5, and to provide cancer therapeutics using an antibody against a cell membrane molecule specifically expressed in these cancer stem cells by identifying said cell membrane molecule. A further objective of the present invention is to provide, using an antibody against a cell membrane molecule specifically expressed in cancer stem cells, a reagent for detecting cancer stem cells, and a method for diagnosing and sorting cancer patients.
|Nucleic acid amplification|
Methods and compositions for the amplification of nucleic acids are disclosed. Amplification methods provided herein may be performed under isothermal conditions.
|Cell separation method|
The present invention provides methods and compositions for separating cells from a sample containing erythrocytes. The method is for recovering desired cells from a sample containing the desired cells, erythrocytes and undesired cells comprising: a) contacting the sample with a composition, said composition comprising: i) an erythrocytes aggregation reagent ii) at least one antigen recognizing moiety coupled to a magnetic particle, wherein said particle with said at least one antigen recognizing moiety specifically binds to at least one antigen specific for one or more undesired cellular components; b) applying simultaneously i) gravity sedimentation for sedimentation of erythrocytes and ii) a magnetic field gradient to said sample for immobilizing said magnetic particle generating a pellet and a supernatant phase, and c) recovering the desired cells from the supernatant phase.
|Soluble urokinase receptor (supar) in diabetic kidney disease|
Methods and compositions are provided for diagnosing and treating a diabetic kidney disease (dkd) in an individual. In aspects of the methods, the levels of soluble circulating urokinase receptor (supar) in the blood are measured to predict a dkd, diagnose a dkd, or provide a prognosis pertaining to a dkd.
|Personal blood glucose meter and abnormal measurement detection method using same|
A personal blood glucose meter and a method for sensing abnormal measurement using the same are disclosed. A personal blood glucose meter includes: a sensor strip for collecting and applying a blood sample, wherein the sensor strip includes a reagent; an electrode unit including a plurality of electrodes for receiving the blood sample from the sensor strip to generate electric current based on potential differences; an mcu for measuring currents value generated from the electrode unit to determine whether a glucose value of the blood sample is normal or abnormal; a potential supply unit for applying a predetermined potential to the electrode unit; and a display unit displaying resultant output from the mcu..
|Image processing apparatus, image processing method, information processing program, fluorescence observation system, and fluorescence navigation surgery system|
An information processing apparatus includes a storage unit, a cutting-out unit, and a display controller. The storage unit is configured to store an image of fluorescence emitted from an observation target area of a living body in a recording medium as a fluorescence image of the observation target area, the image of fluorescence being captured with a first definition, the image of fluorescence being obtained by applying excitation light to the observation target area to which a fluorescent reagent is added in advance.
|Hepatitis b viral variants with reduced susceptibility to nucleoside analogs and uses thereof|
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis b virus (hbv) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies.
|Novel process for the preparation of rebaudioside d and other related naturally occurring sweetners|
A novel process for preparation of rebaudioside d (rd), and other related naturally occurring sweeteners is provided. Rd is a natural sweetening agent which can decrease the bitter aftertaste of steviol glycosides.
|Nucleic acid ligand diagnostic biochip|
A nucleic acid ligand “biochip” is disclosed, consisting of a solid support to which one or more specific nucleic acid ligands is attached in a spatially defined manner. Each nucleic acid ligand binds specifically and avidly to a particular target molecule contained within a test mixture, such as a bodily fluid.
|Methods, reagents and kits for detection of nucleic acid molecules|
Methods, reagents and kits are provided for the production and use in detection assays of labeled nucleic acid molecules wherein a labeling molecule is attached directly to the 3′ end of the nucleic acid molecules.. .
There is provided a diagnostic reagent for use in the detection of m. Bovis or m.
|Systems for immunoassay tests|
This invention relates to a cartridge for an immunoassay test. The cartridge comprises (a) a probe well comprising a probe and a cap, the cap being in a closed position to enclose the probe in the probe well, wherein the probe has a bottom tip coated with analyte-binding molecules, (b) a sample well to receive a sample, (c) one or more reagent wells, (d) a plurality of wash wells each containing a first aqueous solution, and (e) a measurement well having a light transmissive bottom, the measurement well containing a second aqueous solution, wherein the openings of the sample well, reagent well, measurement well and wash wells are sealed.
|Insoluble carrier for use in anti-phospholipid antibody measurement reagent, anti-phospholipid antibody measurement reagent, and method for measuring anti-phospholipid antibody|
The present invention has an object to provide an insoluble carrier for an antiphospholipid antibody detection reagent having a high reactivity. The present invention also has an object to provide an antiphospholipid antibody detection reagent, and a method of detecting an antiphospholipid antibody.
|Method of fabricating testing reagent carrier through ionizing radiation|
A method is provided for modifying a radioactive carbon nanotube (cnt) carrier. Magnetic molecules are used.
|Method and assembly for determining the temperature of a test sensor|
An assembly determines an analyte concentration in a sample of body fluid. The assembly includes a test sensor having a fluid-receiving area for receiving a sample of body fluid, where the fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the sample.
|Reagent for detection and assessment of free chlorine in aqueous solution|
Provided is a heat dried reagent composition that is dry, methods of making it, and methods of using it. The heat dried reagent composition can be characterized by one or more of stability to the heat drying conditions; storage stability of the heat dried reagent composition; fast rehydration time; rapid assay kinetics; and assay precision.
|Reagent for detection and assessment of total chlorine in aqueous solution|
Provided is a heat dried reagent composition that is dry, methods of making it, and methods of using it. The heat dried reagent composition can be characterized by one or more of: stability to the heat drying conditions; storage stability of the heat dried reagent composition; fast rehydration time; rapid assay kinetics; and assay precision.
|Sample analyzer and method for loading reagent container|
Disclosed is a sample analyzer, comprising: a container storage configured to store a plurality of reagent containers; a setting chamber including within a setting portion on which at least one reagent container is set; a container detector for detecting the reagent container on the setting portion; a gate to open and close an entrance of the setting chamber; a transferring section configured to hold the reagent container on the setting portion and transfer it to the container storage; and a controller programmed to initiate the transferring section to transfer the reagent container from the setting portion to the container storage if the reagent container is set on the setting portion when the entrance of the setting chamber is closed by the gate.. .
|Fetal red blood cell detection|
A device for analyzing a maternal blood sample for quantification of the percentage of fetal red blood cells present with respect to the number of maternal red blood cells includes reagents for mixing with the biological sample, a microfluidic chip, 5 fluid reservoirs, a pumping system, an image acquisition system, an image analysis system, and an electronic control board. The microfluidic channel can confine the objects of interest to a monolayer, and may trap them in an organized array for analysis.
|Glutamate oxidase mutagenesis for diagnostic testing|
The described invention provides a method of generating a catalytically active oxidase enzyme preparation. The described invention also provides a means of generating reagents for a protease detection sensor which can use colorimetric, fluorescent, or electrochemical detection.
|Method and reagent kit for measuring activated partial thromboplastin time|
The present invention provides a method for measuring activated partial thromboplastin time. The method comprises: a first mixing step of mixing a blood plasma with a first reagent, wherein the first reagent comprises an activator and phosphatidylglycerol at a concentration equal to or greater than 25 μg/ml; a second mixing step of mixing a sample obtained in the first mixing step with a second reagent comprising a calcium salt; and a step of measuring coagulation time of the sample obtained in the second mixing step..
|Test substance assay method, test substance assay kit, and test substance assay reagent|
The test substance assay method includes (i) obtaining a mixed solution by mixing (a) first dry particles that are modified with first binding substances exhibiting binding properties specific to a test substance, have an average particle size of 100 nm to 200 nm, and have labels, and (b) second dry particles that are modified with second binding substances not exhibiting binding properties specific to the test substance, have an average particle size of 100 nm to 200 nm, and do not have labels with (c) a test sample solution containing the test substance; (ii) applying the mixed solution onto a substrate; (iii) causing the test substance to be trapped in a reaction site on the substrate that has third binding substances having binding properties specific to the test substance or has substances exhibiting binding properties to the first binding substances; and (iv) detecting the test substance.. .
|Sample analyzer, sample analysis method, and non-transitory storage medium|
To provide a sample analyzer capable of accurately obtaining the number of analyzable samples. When analyzing a sample collected from a subject, a cpu of the sample analyzer calculates the number of analyzable samples based on a remaining number of tests of a reagent set in a reagent holding section and the number of tests of the reagent to be consumed in measurement of a control, and causes a output section to display the number of analyzable samples.
|Nucleic acid amplification|
Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions.
|Nucleic acid amplification|
Methods and compositions for the amplification of nucleic acids are disclosed. Amplification methods provided herein may be performed under isothermal conditions.
|Methods for multiplexing recombinase polymerase amplification|
This disclosure provides for methods and reagents for rapid multiplex rpa reactions and improved methods for detection of multiplex rpa reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between rpa processes..
|Methods and compositions for labeling nucleic acids|
The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. In particular, the methods include a [3+2] cycloaddition between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent attached to a label.
|Methods and reagents for preserving rna in cell and tissue samples|
This specification relates to the field of molecular biology and provides novel methods and reagents for preserving and protecting the ribonucleic acid (rna) content of samples from degradation prior to rna isolation. This preservation may be accomplished without ultra-low temperature storage or disruption of the tissue..
|Chain transfer reagents in polyurethane-based photopolymer formulations|
The present invention relates to photopolymer formulations comprising: matrix polymers (a), obtainable by reacting at least one polyisocyanate component (a) and one isocyanate-reactive component (b); a writing monomer (b); a photoinitiator (c); a catalyst (d); and a chain transfer reagent (e). A holographic medium that contains a photopolymer formulation according to the invention or can be obtained by using it, the use of a photopolymer formulation according to the invention for manufacturing holographic media, and a method for producing a holographic medium by using a photopolymer formulation according to the invention are also subject matter of the invention..
|Methods and apparatus for treating exhaust gas in a processing system|
Methods and apparatus for treating an exhaust gas in a foreline of a substrate processing system are provided herein. In some embodiments, an apparatus for treating an exhaust gas in a foreline of a substrate processing system includes a plasma source coupled to a foreline of a process chamber, a reagent source coupled to the foreline upstream of the plasma source, and a foreline gas injection kit coupled to the foreline to controllably deliver a gas to the foreline, wherein the foreline injection kit includes a pressure regulator to set a foreline gas delivery pressure setpoint, and a first pressure gauge coupled to monitor a delivery pressure of the gas upstream of the foreline..
|Surfactantless bimetallic nanostructures and method for synthesizing same|
A bimetallic nanowire synthesis method is provided. The method includes adding first and second solutions into a vessel containing a porous template with the first solution containing first and second reagents added on one side of the porous template and the second solution added on an opposite side of the porous template.
|Process for obtaining a reagent combustible for mixing with other combustibles|
Process for obtaining a reagent combustible for mixing with other combustibles comprising a bio-combustible or an additive related to the field of bi-combustible chemistry and unlikely the bi-combustible and additives found in the market does not become degraded itself and does not degrade the motor components; further, it is a universal combustible or additive, that is, it can mixed with any other combustible either biological, fossil and mineral. Said combustible or said additive for use with explosion motors is produced from sunflower refined oil or any other type of vegetal or seaweed oil preferably without conservatives and uses as reagents the following components: ethyl alcohol 96° gl (93.8° inpm) or 95.3° gl (92.8° inpm), ethyl alcohol 77° gl (70° inpm), sodium hydroxide naoh (97%), boric acid h3bo3 (99.7% min.), hydrochloric acid hcl, purified or distilled water.
|Analysis assisting method, analyzer, remote computer, data analyzing method, program, and reagent container|
In an analysis system having an analysis apparatus using a reagent container having a memory to store reagent information concerning the reagent in the reagent container and a remote computer, the following steps are executed: reading out the reagent information from the memory of the reagent container; judging, based on the read reagent information, whether or not the reagent in the reagent container is usable; when it is judged that the reagent in the reagent container is unusable, writing data representing the reagent is unusable into the memory of the reagent container; and when it is judged that the reagent in the reagent container is unusable, registering the data representing the reagent is unusable, into a reagent database managed by the remote computer in association with identification information to identify the reagent container. Thus, it is possible to automatically identify the reagent, which should not be used, and to manage the reagent not so as to use it for the analysis.
|Synthesis of cyclosporin analogs|
The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine a. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives.
|Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina)|
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (sina), short interfering rna (sirna), double-stranded rna (dsrna), micro-rna (mirna), and short hairpin rna (shrna) molecules capable of mediating rna interference (rnai) against target nucleic acid sequences.
|Reagent container pack|
A reagent container pack for storing, preserving, and automatically unsealing and resealing a plurality of reagent containers in a reagent container pack on-board an automated clinical sample analyzer for analyzing analytes in a body fluid.. .
|System and method for optical detection using capillary action|
A system and method for the detection of one or more analytes in a collected sample employs capillary action in a sample card containing a sample substrate, at least one test capsule and an absorbent pad. The absorbent pad absorbs the contents of the test capsule and delivers the same to the sample substrate, with the contents of the test capsule chemically reacting with at least one detection reagent to establish an optical indicator for the analyte(s).
|Method of lipid assay and reagent for use therein|
A method of lipid assay characterized by assaying the lipids contained in a blood component in the presence of an organic silicon compound. The method can cause specific conditions for direct methods while satisfying requirements such as no influence on precision of assay, no burden on assay apparatus, and easy availability..
|Melittin peptide conjugates and methods employing same|
Methods and reagents are disclosed for conducting assays for ige specific for honey bee venom allergen. A reagent comprises a conjugate of a small molecule linked to a terminal glycine amino acid of a synthetic 26 amino acid melittin peptide.
|Reagents and methods for detecting pnh type ii white blood cells and their identification as risk factors for thrombotic disorders|
The disclosure relates to methods for detecting pnh type ii cell populations in biological samples as well as methods for determining whether a patient is at an increased risk for developing thrombocytopenia or thrombosis based on the percentage of pnh type ii cells in the patient's blood. The disclosure also features reagents and conjugates for use in the methods..
|Giant obscurins and uses thereof in cancer prognosis and therapy|
Provided herein are methods and kits for evaluating potential for invasiveness, metastasis, or recurrence of an epithelial cell cancer. In the methods the expression profile of giant obscurins is detected in a tissue sample of tumor cells or suspected tumor cells and assessed for giant obscuring expression level and distribution therein.
|Apparatus for automated processing biological samples|
The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.. .
|Test strip for measuring biological fluid|
The invention relates to a test strip. The test strip comprises an insulating sheet; a metallic circuit layer disposed on the insulating sheet, the metallic circuit layer including at least an electrode section; a sensing reagent layer provided on the electrode section; an intermediate layer disposed to cover the insulating sheet and the metallic circuit layer, the intermediate layer having an opening to expose the sensing reagent layer and the electrode section; and a cover disposed to cover the intermediate layer and the insulating sheet, and expose part of the metallic circuit layer, the cover having two holes corresponding to the opening.
|Automated reagent manager of a diagnostic analyzer system|
A reagent manager for a diagnostic analyzer system includes a reagent manager housing, a high-speed reagent bottle spinning device, a processor, and a memory. The reagent manager housing is for housing reagent bottles.
|Method of fabricating test strip of biological fluid|
The invention provides a method of fabricating test strips for measuring biological blood. The method comprises steps: preparing an insulating membrane material; printing a metallic circuit layer on the insulating membrane material by a metallic ionic ink; performing a surface treatment for the metallic circuit layer expose metallic ions of the metallic ionic ink; chemical plating for the exposed metallic ions of the metallic circuit layer to form an electrode section on the metallic circuit layer; providing a sensing reagent on the electrode section to form a sensing reagent layer; sequentially adhering an intermediate layer and a cover to the insulating membrane material to cover the metallic circuit layer and expose part of the metallic circuit layer; and cutting the insulating membrane material to form a plurality of insulating sheets.
|Method and device for ionizing particles of a sample gas glow|
A device for ionizing particles (molecules or clusters) of a sample gas flow comprises a first flow tube for providing the sample gas flow, and a generator for producing reagent primary ions from particles of candidate reagent gas flow at a primary ion production region. The device also has an interaction region for introducing the reagent ions into the sample gas flow in order to arrange interaction between the reagent primary ions and the particles of the sample gas flow, thereby producing sample gas ions to be delivered to a detector.
|Thermochemical reaction ablation catheter|
Embodiments disclosed herein are directed to devices, methods, and systems for the treatment of tissue using energy delivery. Specifically, certain embodiments may utilize a thermochemical reaction between at least two reagents where a first reagent has been preloaded into a catheter while a limiting reagent is circulated through the catheter to react with the first reagent.
|Novel enhanced device and composition for local drug delivery|
A medical device for delivering a reagent, such as a pharmaceutical agent, a diagnostic agent, a nutrient, or another type of reagent, to an intravascular or intralumenal location, is disclosed. The medical device has a coating, where exposing the coating to light severs a photosensitive bond that releases the reagent into the immediate vicinity of the location..
|System and method for allergy testing|
An allergy testing device is formed by a blister pack containing a series of collapsible chambers each associated with an allergen and a lancet. The allergy testing device may be placed adjacent to a patient's skin and actuated by applying pressure to the collapsible chambers to open the chambers and release the reagents contained therein.