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Quinoline patents



      
           
This page is updated frequently with new Quinoline-related patent applications. Subscribe to the Quinoline RSS feed to automatically get the update: related Quinoline RSS feeds. RSS updates for this page: Quinoline RSS RSS


Date/App# patent app List of recent Quinoline-related patents
01/22/15
20150025108
 8-hydroxy quinoline derivatives patent thumbnailnew patent 8-hydroxy quinoline derivatives
Or pharmaceutically acceptable salts, hydrates, or solvates thereof.. .
01/22/15
20150025085
 Iron chelators and uses thereof patent thumbnailnew patent Iron chelators and uses thereof
8-hydroxy-quinoline derivatives and 8-ethers, 8-esters, 8-carbonates, 8-acyloxymethyl, 8-phosphates, 8(phosphoryloxy)methyl, and 8-carbamates derivatives thereof substituted at the 5-position are described as useful for iron chelation and neuroprotective therapies.. .
Varinel Inc.
01/22/15
20150024047
 Pharmaceutical composition and administrations thereof patent thumbnailnew patent Pharmaceutical composition and administrations thereof
The present invention relates to pharmaceutical compositions containing a solid dispersion of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.. .
Vertex Pharmaceuticals Incorporated
01/22/15
20150023990
 Alkoxy substituted imidazoquinolines patent thumbnailnew patent Alkoxy substituted imidazoquinolines
Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.. .
3m Innovative Properties Company
01/22/15
20150023930
 Aminoquinoline derivatives and uses thereof patent thumbnailnew patent Aminoquinoline derivatives and uses thereof
Described herein are aminoquinoline and aminoacridine based hybrids, pharmaceutical compositions and medicaments that include such aminoquinoline and aminoacridine based hybrids, and methods of using such compounds for diagnosing and/or treating infections, neurodegerative diseases or disorders, inflammation, inflammation associated diseases and disorders, and/or diseases or disorders that are treatable with dopamine agonists such as the restless leg syndrome.. .
The Mclean Hospital Corporation
01/08/15
20150011770
 Group 4 metal compound containing thiophene-fused cyclopentadienyl ligand derived from tetraquinoline derivative and olefin polymerization using the same patent thumbnailGroup 4 metal compound containing thiophene-fused cyclopentadienyl ligand derived from tetraquinoline derivative and olefin polymerization using the same
The present invention relates to a novel ligand derived from a tetrahydroquinoline derivative, and a transition metal compound prepared using the ligand, where an amido ligand is linked to an ortho-phenylene ligand to form a condensed ring and a 5-membered cyclic pi-ligand linked to the ortho-phenylene ligand is fused with a heterocyclic thiophene ligand. Compared with the catalysts not fused with a heterocyclic thiophene ligand, the transition metal compound of the present invention as activated with a co-catalyst has higher catalytic activity in olefin polymerization and provides a polymer with higher molecular weight..
Lotte Chemical Corporation
01/08/15
20150010628
 Pharmaceutical composition and administrations thereof patent thumbnailPharmaceutical composition and administrations thereof
The present invention relates to pharmaceutical compositions containing a solid dispersion of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders and mini-tablets and methods for treating cystic fibrosis employing the pharmaceutical composition.. .
Vertex Pharmaceuticals Incorporated
01/01/15
20150004231
 Formulations and pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 patent thumbnailFormulations and pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (vmat2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.. .
Auspex Pharmaceuticals, Inc.
01/01/15
20150000691
 Coupler with 7-amino-1,2,3,4-tetrahydroquinoline structure, dyeing composition comprising same, processes and uses patent thumbnailCoupler with 7-amino-1,2,3,4-tetrahydroquinoline structure, dyeing composition comprising same, processes and uses
The invention relates to the use of specific heterocyclic couplers which are 7-amino-1,2,3,4-tetrahydroquinoline derivatives of formula (i) for dyeing keratin fibres such as the hair in which formula (i): r1 to r6, ra to rc and x are as defined in the description.. .
L'oreal
12/25/14
20140378718
 Method for reducing acids in crude oil patent thumbnailMethod for reducing acids in crude oil
Introducing an additive into a crude oil may result in the crude oil having comparatively lower acid levels as compared to an otherwise identical crude oil absent the additive. The additive may include nanoparticles of metal oxides, oil soluble hydrogen donors, and/or heavy amines.
Baker Hughes Incorporated
12/25/14
20140378711

Method for synthesizing 2,7-dimethyl-2,4,6-octatriene-1,8-dialdehyde


Provided in the present invention is a method for synthesizing 2,7-dimethyl-2,4,6-octatriene-1,8-dialdehyde. The synthesis method comprises the following steps: (1) adding acetaldehyde diethyl acetal and ethyl-(1-propenyl)-ether under the effect of a catalyst to produce 1,1,3-triethoxy-2-methyl-butane; (2) pyrolysis synthesizing 1,1,3-triethoxy-2-methyl-butane under the catalytic effects of isoquinoline and p-toluenesulfonic acid to produce 1-methoxy-2-methyl-1,3-butadiene; (3) dissolving 1-methoxy-2-methyl-1,3-butadiene in anhydrous ethanol solvent for synthesis with a phase transfer catalyst, cetyl-trimethyl ammonium bromide, and a chlorinating agent, trichloroisocyanuric acid, to generate 4,4-diethoxy-3-methyl-1-chloro-butene; (4) combining 4,4-diethoxy-3-methyl-1-chloro-butene with a triphenylphosphine salt to produce a phosphonium salt; and (5) condensing the phosphonium salt under the effects of hydrogen peroxide in conjunction with sodium carbonate solution to generate 1,1,8,8-tetramethyl-2,7-dimethyl-2,4,6-octatriene; then hydrolyzing under acidic conditions to synthesize 2,7-dimethyl-2,4,6-octatriene-1,8-dialdehyde.
Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
12/25/14
20140378441

Therapeutic agent for ocular fundus disease


Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (s)-(−)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient..
Kowa Company, Ltd.
12/25/14
20140377783

Novel applications of indoloindole and indoloquinoline dyes


A novel type of dye systems comprises a selection of 10h-indolo[1,2-a]indole compounds (henceforth abbreviated as io compounds) and (5h,7h)-indolo[1,2-a]quinoline compounds (henceforth abbreviated as iq compounds) showing a solvatochromic effect and exhibiting strong fluorescence in a variety of materials such as polypropylene, polyethylene, oils, various solvents, emulsions. Also disclosed are various methods how the io/iq compounds can be administered, especially how they can be produced and administered in situ from a precursor, responding to external stimuli such as enzyme activity, temperature and so forth.
12/25/14
20140373989

Tire


The present invention aims to provide a tire having improved abrasion resistance and appearance, as well as reduced rolling resistance and therefore improved fuel economy. The present invention relates to a tire including a tread, the tread containing 0.9 to 1.5% by mass of a wax, 0.9 to 1.5% by mass of an amine antioxidant, 0.3 to 1.0% by mass of a quinoline antioxidant, and a tread rubber component containing 3% by mass or more of a polybutadiene rubber, the tread having a rubber thickness between a tread groove bottom and an outermost belt-reinforcing layer of 0.1 to 2.0 mm..
Sumitomo Rubber Industries, Ltd.
12/25/14
20140373286

Oxidative dyeing composition


Present invention relates to an aqueous oxidizing composition with improved stability. The object of the present invention is an aqueous composition comprising at least one oxidizing agent, salicylic acid and/or its salts and either acetaminophen or oxyquinoline and/or its salts and having a ph between 1 and 5..
Kao Germany Gmbh
12/18/14
20140371459

Industrial process for preparation of 1,2-dihydroquinoline derivative or a salt thereof, and intermediate for preparation thereof


Or a salt thereof in the presence of a base. The method is a method for producing a 1,2-dihydroquinoline derivative having glucocorticoid receptor binding activity or a salt thereof.
12/18/14
20140371259

Compounds and methods for inhibition of ap endonuclease-1/redox factor-1 (hape1) activity


A method for treating a neoplasm in a subject, comprising co-administering to the subject a therapeutically effective amount of an anticancer agent and a substituted 6,7-methylenedioxy-4-amino-quinoline, or a pharmaceutically acceptable salt or ester thereof.. .
University Of Pittsburgh - Of The Commonwealth System Of Higher Education
12/18/14
20140371221

Quinoline compound composing 1,2,4-triazine-dione and use thereof


The present invention relates to a quinoline derivative represented by general formula (i) or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof wherein ar, r1, r2, r3, x, y and n have the meanings given in the description. The present invention also relates to the comparatively strong effect of the compound represented by general formula (i) on inhibiting c-met kinase.
Wuhan Shengyun Biopharma Co., Ltd.
12/11/14
20140364613

Compounds of 3-(5-sustituted oxy-2, 4-dinitrophenyl)-2-oxo-propionic acid ester, synthesis and applications thereof


Synthesis of the novel compound 3 (3-(5-substituted oxy-2,4-dinitro-phenyl)-2-oxo-propionic acid ester) to make pyrroloquinoline quinone (pqq) and using it for pharmaceutical purposes is described. More specifically, this disclosure relates to synthesizing the pqq in an efficient method by using a novel intermediate formula 1 resulting in a shorter process and higher yield of pqq.
12/11/14
20140364454

Metal-chelating compounds having at least one polyamino chain


The invention relates to metal-chelating compounds comprising one or more 8-hydroxyquinoline units substituted in position 2 with a nitrogenous group comprising a polyamino chain, wherein the polyamino chain is n-substituted on said nitrogenous group, to the composition containing same, and to the uses thereof in the therapeutic field and in particular in the treatment of diseases associated with an abnormality in the regulation of metal metabolism resulting in a metal overload in human or animal cells.. .
12/11/14
20140364441

Crystalline forms of (s)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof


Novel [1,2,4]triazolo[1,5-a]pyridinyl-6-yl-substituted tetrahydroisoquinolines are described in the present invention. These compounds and crystalline forms sa1 and n-2 are used in the treatment of various neurological and physiological disorders.
12/11/14
20140364431

Quinoline and cinnoline derivatives and their applications


The present invention relates to a series of quinoline and cinnoline derivatives of general formula i, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof. And the compounds of general formula i show potent inhibitory activity gainst c-met kinase.
12/11/14
20140364424

Novel sulfonaminoquinoline hepcidin antagonists


The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.. .
12/11/14
20140364389

Combination therapy


The present invention relates to a combination therapy for treating an hiv infection or inhibiting integrase comprising (s)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxymethyl-2-methylpropyl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (“compound a”) or a pharmaceutically acceptable solvate or salt thereof in combination with at least one other anti-hiv agent. In some embodiments of the present invention, the other anti-hiv agents are chosen from reverse transcriptase inhibitors and protease inhibitors.
12/11/14
20140361252

Aluminum chelates as materials for oleds


Aluminum chelate complex compounds with two substituted 8-hydroxyquinoline ligand and one dibenzothiophene, dibenzofuran or dibenzoselenophene ligands or aza-analogs of these molecules, attached directly or through an aromatic spacer to the oxygen atom is provided to improve lifetime, operating voltage and efficiency of an oled. Additional substitution of dibenzothiophene or dibenzofuran ring may also provide charge delocalization, homo modification and higher tg..
12/04/14
20140357768

Color-stable thermoplastic composition


Wherein z1 represents the atoms necessary to complete a 9- to 13-membered single or fused aromatic ring structure, z2 represents the atoms necessary to complete a pyridine or quinoline ring, each r1 and each r2 can independently be halogen, an alkyl group, an aryl group, a heterocyclic group, an alkoxy group, an aryloxy group, an aromatic or aliphatic thioether group, an aromatic or aliphatic carboxylic acid ester group, or an aromatic or aliphatic amide group, a is an integer from 0 to 6, b is an integer from 0 to 4, n is 1 or 2, and x is present only if n=2 and is a single bond or a divalent organic radical bonded to the z1 ring structure through an ether, ketone, or thio linkage.. .
12/04/14
20140356873

Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings


The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings.
12/04/14
20140352713

Coupler with cationic 7-amino-1,2,3,4-tetrahydroquinoline structure, dyeing composition comprising same, processes and uses


The invention relates to the use of specific heterocyclic couplers which are cationic 7-amino-1,2,3,4-tetrahydroquinoline derivatives of formula (i) for dyeing keratin fibres such as the hair: in which formula (i): r1 to r6, cat+, an−, and ra to rb are as defined in the description.. .
11/27/14
20140350264

Process for the preparation of (5-fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-acetic acid esters


The invention relates to a process for the preparation of a compound of formula (i) wherein r1 is c1c6 alkyl or benzyl by reacting a compound of formula (ii) wherein r1 is as defined for formula (i) with 2-quinoline carboxaldehyde. The process is suitable for use on an industrial scale..
11/27/14
20140350048

Compounds, compositions and associated methods comprising 3-aryl quinolines


Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and methods of treating infectious diseases such as malaria, are disclosed..
11/27/14
20140350044

Benzoquinoline inhibitors of vesicular monoamine transporter 2


The present invention relates to new benzoquinoline inhibitors of vesicular monoamine transporter 2 (vmat2), pharmaceutical compositions thereof, and methods of use thereof.. .
11/20/14
20140343480

Systems, methods, and compositions for cross-linking


Various agents and additives for cross-linking treatments are identified in disclosed studies. The characteristics of the various agents and additives may be advantageously employed in formulations applied in cross-linking treatments of the eye.
11/20/14
20140343096

Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof


The subject invention provides deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, its salts and uses.. .
11/20/14
20140343063

Method of treating a viral infection using elvitegravir combinations


The invention includes methods, compositions, and kits useful for treating a viral infection by administering 6-(3-chloro-2-fluorobenzyl)-1-[(2s)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or a pharmaceutically acceptable salt thereof, with atazanavir or a pharmaceutically acceptable salt thereof, and optionally with a compound that inhibits cytochrome p-450, or a pharmaceutically acceptable salt thereof.. .
11/20/14
20140343062

Method of treating a viral infection using elvitegravir combinations


The invention includes methods, compositions, and kits useful for treating a viral infection by coadministering 6-(3-chloro-2-fluorobenzyl)-1-[(2s)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or a pharmaceutically acceptable salt thereof, with lopinavir or a pharmaceutically acceptable salt thereof.. .
11/20/14
20140343036

Isoquinoline and naphthyridine derivatives


Wherein a, r1 and r2 are as described herein, compositions including the compounds and methods of using the compounds.. .
11/20/14
20140341994

Formulations and pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2


The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (vmat2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.. .
11/13/14
20140336393

Process for preparing modulators of cystic fibrosis transmembrane conductance regulator


The present invention relates to processes for preparing solid state forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including compound 1 form a, compound 1 form a-hcl, compound 1 form b, and compound 1 form b-hcl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.. .
11/13/14
20140336386

Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2


The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (vmat2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.. .
11/13/14
20140336262

Pharmaceutical compositions comprising napthamides


Disclosed herein are naphthamide and quinoline carboxamide compounds containing two bicyclic moieties, pharmaceutical compositions comprising those compounds and methods of using the compositions in the treatment of cancers mediated by cyclic-amp (camp) response element binding protein (creb). The disclosed compositions have utility in the treatment of lung, prostate and breast cancers in a human subject..
11/13/14
20140336221

Antibiotic and anti-parasitic agents that modulate class ii fructose 1, 6-bisphosphate aldolase


This invention provides a family of compounds that inhibit class ii fructose 1,6-bisphosphate aldolase (fba), which is implicated in the pathogenic activity of a broad range of bacterial and parasitic agents. The compounds were identified by empirical testing, and provide a basis for further derivatization and optimization of 8-hydroxyquinoline-2-carboxylic acid and related compounds.
11/13/14
20140336188

N-substituted indenoisoquinolines and syntheses thereof


N-substituted indenoisoquinoline compounds, and pharmaceutical formulations of n-substituted indenoisoquinoline compounds are described. Also described are processes for preparing n-substituted indenoisoquinoline compounds.
11/06/14
20140329855

Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide


The present invention relates to solid state forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (compound 1), pharmaceutical compositions thereof and methods therewith.. .
11/06/14
20140329852

N-(imidazolidin-2-ylidene)quinoline derivatives as modulators of alpha 2 adrenergic receptors


The present invention relates to novel n-(imidazolidin-2-ylidene)quinoline derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.. .
10/30/14
20140323731

Lipidated imidazoquinoline derivatives


The compounds of the subject invention are adjuvant molecules that comprise an imidazoquinoline molecule covalently linked to a phospho- or phosphonolipid group. The compounds of the invention have been shown to be inducers of interferon-a, il-12 and other immunostimulatory cytokines and possess an improved activity profile in comparison to known cytokine inducers when used as adjuvants for vaccine antigens..
10/30/14
20140323521

Pharmaceutical compositions and administrations thereof


The present invention relates to the use of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, solids forms, and pharmaceutical compositions thereof for the treatment of cftr mediated diseases, particularly cystic fibrosis, in patients possessing specific genetic mutations.. .
10/30/14
20140323311

Pesticidal mixtures


The present invention relates to an agrochemical mixture for increasing the health of a plant, comprising as active ingredients a herbicidal compound (i) selected from the group consisting of: benzoic acids, pyridine carboxylic acids, quinoline carboxylic acids, and benazolin-ethyl; and a fungicidal compound (ii) in synergistically effective amounts. The present invention further relates to a method for improving the health of a plant, wherein the plant, the locus where the plant is growing or is expected to grow or plant propagation material from which the plant grows is treated with an effective amount of a mixture as defined above.
10/30/14
20140323310

Pesticidal mixtures


The present invention relates to an agrochemical mixture for increasing the health of a plant, comprising as active ingredients a herbicidal compound (i) selected from the group consisting of: benzoic acids, pyridine carboxylic acids, quinoline carboxylic acids, and benazolin-ethyl; and a fungicidal compound (ii) in synergistically effective amounts. The present invention further relates to a method for improving the health of a plant, wherein the plant, the locus where the plant is growing or is expected to grow or plant propagation material from which the plant grows is treated with an effective amount of a mixture as defined above.
10/30/14
20140323302

Process for the preparation of a quinoline carboxylic acid


The invention provides a process for the preparation of a carboxylic acid of formula (iv) (which is useful as a safener for herbicides): wherein r1 is hydrogen or chlorine, comprising the steps of: (i) subjecting a compound of formula (v) wherein: r1 is as defmed above; and r2 is c1-c18 alkyl; c1-c6 alkoxyc1-c8 alkyl-; optionally substituted phenyl; or optionally substituted benzyl; to hydrolysis under acidic conditions to give a solution of a quinolinium salt; and (ii) addingbase to the solution obtained in step (i) to give the free carboxylic acid (iv). The invention also provides a solid (e.g.
10/30/14
20140322296

Piperaquine microcapsules and compositions containing them


The present invention provides a microcapsule pharmaceutical composition of at least a bisquinoline drug. Said microcapsule comprises a drug core of a pharmaceutically effective amount of a bisquinoline drug and a polymeric coating over the core.
10/23/14
20140315948

Pharmaceutical composition and administrations thereof


The present invention relates to pharmaceutical compositions comprising a solid dispersion of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.. .
10/23/14
20140315944

Substituted naphthyridine and quinoline compounds as mao inhibitors


Wherein r1, r2, r3, y, and n have any of the values described herein and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting mao, and mao-b selectively, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a cns disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating peripheral disorders (including obesity, diabetes, and cardiometabolic disorders) and their associated co-morbidities.. .
10/16/14
20140309227

Quinoline carboxamide and quinoline carbonitrile derivatives as mglur2-negative allosteric modulators, compositions, and their use


The present invention provides quinoline carboxamide and quinoline carbonitrile compounds of formula (i) wherein ring a, rq, -l-, r1, n, r2, and r3 are as defined herein. The compounds of the invention are useful as non-competitive mglur2 antagonists, or mglur2 negative allosteric modulators (nams), and in methods of treating a patient (preferably a human) for diseases or disorders in which the mglur2-nam receptor is involved, such as alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders, by administering to the patient a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof.
10/02/14
20140296528

4-aryl-1-(biarylmethylene) piperidine compounds


The 4-aryl-1-(biarylmethylene)piperidine compounds are piperadine compounds having a biaryl substituent linked to the nitrogen atom of the piperidine ring by a methylene (—ch2—) group, and an aryl moiety attached to the 4-position of the piperidine ring. The aryl moiety may be a methoxy quinoline group, a 2-oxo quinoline group, or a 2-oxo, 3,4-dihydroxy quinoline group.
10/02/14
20140296251

Multifunctional quinoline derivatives as anti-neurodegenerative agents


Novel quinoline derivatives are disclosed. Also disclosed are synthesis and use thereof for treating neurodegenerative diseases..
10/02/14
20140296236

Quinolines as fgfr kinase modulators


The invention relates to new quinoline derivative compounds of formula (i), to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. Cancer.
10/02/14
20140296224

Quinoline derivatives as pi3 kinase inhibitors


Invented is a method of inhibiting the activity/function of pi3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives..
10/02/14
20140296215

Cyanoquinoline compounds having activity in correcting mutant-cftr processing and increasing ion transport and uses thereof


The present disclosure provides pharmaceutical compositions, pharmaceutical preparations and methods for increasing activity of a mutant cystic fibrosis transmembrane conductance regulator protein (mutant-cftr). The pharmaceutical compositions, pharmaceutical preparations and methods are useful for the study and treatment of disorders associated with mutant-cftr, such as cystic fibrosis.
10/02/14
20140296214

Substituted tetrahydroisoquinoline compounds as factor xia inhibitors


The present invention provides compounds of formula (i): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor xia and/or plasma kallikrein which may be used as medicaments..


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Quinoline topics: Isoquinolin, Praziquantel, Carbon Atoms, Crystallin, Quinoline Derivatives, Pharmaceutically Acceptable Salt, Alkyl Group, Cycloalkyl, Pharmaceutically Acceptable Salts, Immunodeficiency, Retrovirus, Viral Infection, Human Immunodeficiency Virus, Angiogenesis, Sulfonamide

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This listing is a sample listing of patent applications related to Quinoline for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Quinoline with additional patents listed. Browse our RSS directory or Search for other possible listings.
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