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Quinoline patents

      

This page is updated frequently with new Quinoline-related patent applications.




 Novel imidazo[4,5-c]quinoline and imidazo[4,5-c][1,5]naphthyridine derivatives as lrrk2 inhibitors patent thumbnailNovel imidazo[4,5-c]quinoline and imidazo[4,5-c][1,5]naphthyridine derivatives as lrrk2 inhibitors
Wherein r1, r1a, r1b, r2, r4, r5, r6, x and z are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of formula (i) and to use of the compounds in the treatment of diseases associated with lrrk2, such as neurodegenerative diseases including parkinson's disease or alzheimer's disease, cancer, crohn's disease or leprosy..

 Crystalline form of 6-[(4r)-4-methyl-1,2-dioxido-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile patent thumbnailCrystalline form of 6-[(4r)-4-methyl-1,2-dioxido-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile
This invention relates to a novel crystalline form of 6-[(4r)-4-methyl-1,1-dioxido-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile which is useful as a selective androgen receptor modulator (sarm), and to compositions thereof and suitable processes for the preparation thereof.. .
Pfizer Inc.


 Substituted tetrahydroisoquinoline compounds as factor xia inhibitors patent thumbnailSubstituted tetrahydroisoquinoline compounds as factor xia inhibitors
Or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor xia and/or plasma kallikrein which may be used as medicaments..

 Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds patent thumbnailBeta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents.
Aerie Pharmaceuticals, Inc.


 Methionine aminopeptidase inhibitors for treating infectious diseases patent thumbnailMethionine aminopeptidase inhibitors for treating infectious diseases
The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivative thereof or a pharmaceutical salt thereof..
Texas Southern University


 Methionine aminopeptidase inhibitors for treating infectious diseases patent thumbnailMethionine aminopeptidase inhibitors for treating infectious diseases
The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivative thereof or a pharmaceutical salt thereof..
The Board Of Regents Of The University Of Texas System


 Methionine aminopeptidase inhibitors for treating infectious diseases patent thumbnailMethionine aminopeptidase inhibitors for treating infectious diseases
The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivative thereof or a pharmaceutical salt thereof..
The Board Of Regents Of The University Of Texas System


 N-ethyl-n-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide, preparation and uses thereof patent thumbnailN-ethyl-n-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide, preparation and uses thereof
The subject invention provides a pharmaceutical composition containing laquinimod or a pharmaceutically acceptable salt thereof, and a compound of n-ethyl-n-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide or a salt thereof.. .
Teva Pharmaceutical Industries, Ltd.


 Organic electroluminescent materials and devices patent thumbnailOrganic electroluminescent materials and devices
Novel iridium complexes with 5-member heteroaryl ring fused quinoline ligands are disclosed. These complexes are useful as phosphorescent emitters in oleds with improved emission properties..
Universal Display Corporation


 Isoquinoline derivatives and use thereof patent thumbnailIsoquinoline derivatives and use thereof
The invention provides compounds of formula (i) and pharmaceutically acceptable salts, solvates, hydrates, n-oxides, or diastereomers thereof: wherein w1, w2, w3, j1, j2, a, r1, r2, r3, r4, r5, a, and b are defined as set forth in the specification. The invention also provides uses of the compounds of any one of formulae (i)-(viii) and the pharmaceutically acceptable salts, solvates, hydrates, n-oxides, or diastereomers thereof.
Purdue Pharma L.p.


Bosutinib forms and preparation methods thereof

The present subject matter relates to solvates and the amorphous form of bosutinib; the solvates namely being a propylene glycol solvate and an acetonitrile solvate. Also provided are processes for preparing the propylene glycol solvate, the amorphous form and the crystalline acetonitrile solvate of bosutinib; as well as compositions comprising said forms.
Apotex Inc.

Chemically modified quinoline and quinolone derivatives useful as cb-1 inverse agonists

Wherein the group “x═y”, ring a, r10, r11, r30, w, and t are defined herein.. .

Processes for preparing quinoline compounds and pharmaceutical compositions containing such compounds

The present invention is directed to processes for making and compositions containing quinolines such as formula i or pharmaceutically acceptable salts thereof wherein: x1 is h, br, cl, or x2 is h, br, cl, or n1 is 1-2; and n2 is 1-2.. .
Exelixis, Inc.

Organic electroluminescent materials and devices

This invention discloses iridium complexes with benzothienoquinoline, benzofuroquinoline, benzoselenophenoquinoline, and benzosiloloquinoline ligands. These complexes can be used as phosphorescent emitters in oleds..
Universal Display Corporation

Organic electroluminescent materials and devices

Novel phosphorescent metal complexes containing 2-phenylisoquinoline ligands with at least two substituents on the isoquinoline ring are provided. The disclosed compounds have low sublimation temperatures that allow for ease of purification and fabrication into a variety of oled devices..
Universal Display Corporation

Inhibitors of jmjd2c as anticancer agents

The present disclosure provides compounds, pharmaceutical compositions and related methods for the treatment of cancer, e.g., castration-resistant prostate cancer (crpc). Specifically, the present disclosure provides a series of 8-hydroxyquinoline derivatives which show cytotoxic effects on androgen-independent prostate cancer cells..
The J. David Gladstone Institutes

Isoquinolinesulfonyl derivative as rho kinase inhibitor

The present invention discloses a class of isoquinolinesulfonyl derivatives as rho kinase inhibitors, and pharmaceutical compositions thereof, and relates to pharmaceutically acceptable uses thereof. Specifically, the present invention relates to a compound as represented by formula (i), or a pharmaceutically acceptable salt thereof..
Medshine Discovery Inc.

Novel substituted imidazoquinolines

Imidazoquinolines of formula i that contain substituted amine or amide functionality at 1-position and that are effective as toll like receptor 7 activators are disclosed. These compounds are useful as anticancer agents..
4sc Ag

Toll-like receptor-7 and -8 modulatory 1h imidazoquinoline derived compounds

The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using such compounds. The present disclosure also provides tlr7 agonists and tlr7/tlr8 dual agonists, probes, tissue-specific molecules, adjuvants, immunogenic compositions, therapeutic compositions, and self-adjuvanting vaccines including the imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof.
The University Of Kansas

Selective androgen receptor degrader (sard) ligands and methods of use thereof

This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (sard) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other ar-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, kennedy's disease, amyotrophic lateral sclerosis (als), abdominal aortic aneurysm (aaa), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (ar-fl) including pathogenic and/or resistance mutations, ar-splice variants (ar-sv), and pathogenic polyglutamine (polyq) polymorphisms of ar in a subject.. .
University Of Tennessee Research Foundation

Combination

The present invention relates to a method of treating breast cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a breast cancer treatment method that includes administering 5-[[4-[(2,3-dimethyl-2h-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, and (s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1h-pyrano[3′,4′:6,7] indolizino [1,2-b]quinoline-3,14-(4h,12h)-dione, or a pharmaceutically acceptable salt thereof, to a human in need thereof..
Sunnybrook Research Institute

Use of substitute oxo tetrahydroquinoline sulfonamides or salts thereof for raising stress tolerance of plants

Where the radicals in the general formula (i) correspond to the definitions given in the description, for enhancing stress tolerance in plants to abiotic stress, and/or for increasing plant yield.. .

Polymorphic forms of 4,5-dihydro-1h-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid and its disodium salt, process for their preparation and their use

The present disclosure relates to polymorphic form of pqq and/or its salts represented by formula (i), wherein “n” and “m” are selected from a group consisting of: (a) “n”=3, “m”=0 and (b) “n”=1, “m”=2; and; r3 is na+. The present disclosure also relates to a process for preparing the polymorphic form of compound of formula (i) and/or its salts, a composition comprising the polymorphic form of compound of formula (i) and/or its salts and use thereof..
Anthem Biosciences Private Limited

Drug therapy for preventing or treating glaucoma

There is provided a drug therapy for prevention of glaucoma or prevention or treatment of ocular hypertension, with a potent ocular hypotensive effect and prolonged duration thereof. Disclosed is a combination of (s)-(−)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine or a salt thereof, or a solvate thereof, and a prostaglandin for prevention or treatment of glaucoma..
Kowa Co., Ltd.

Preventive/therapeutic method and preventive/therapeutic agent for complications after cataract surgery

The present invention relates to a preventive/therapeutic method comprising administering to a subject a medicine containing 4-fluoro-5-{[(2s)-2-methyl-1,4-diazepan-1-yl]sulfonyl}isoquinoline (ripasudil) or a salt thereof, or a solvate thereof as an active ingredient.. .

Dietary supplement for improving brain health

Compositions that can be used to improve human health, and in particular brain health are provided. In some embodiments the composition comprises inositol, n-acetyl l-tyrosine, pyrroloquinoline quinone (pqq), choline bitartrate, l-theanine and acetyl-l-carnitine.
Braingear Enterprises, Inc.

Organic electroluminescent materials and devices

This invention discloses novel ligands for metal complexes. These ligands contain a phenyl with an iso-quinoline (or other type of heterocycles) which are bridged together with a carbon substituted by two aliphatic side chains.
Universal Display Corporation

Organic-electroluminescent-element material and organic electroluminescent element using same

Disclosed is an organic electroluminescent device (organic el device) that is improved in luminous efficiency, sufficiently secures driving stability, and has a simple construction. The device is an organic electroluminescent device having organic layers including a light-emitting layer between an anode and a cathode laminated on a substrate, in which a carborane compound is incorporated into at least one layer of the organic layers, or is incorporated as a host material into a light-emitting layer containing a phosphorescent light-emitting dopant and the host material.
Nippon Steel & Sumikin Chemical Co., Ltd.

Quinoline compounds

The present invention relates to quinoline compounds as defined by formula i below. Such quinoline compounds have been shown to inhibit the formation of amyloid deposits (e.g., amyloid oligomers, fibrils or plaques).
Oxford University Innovation Limited

Quinolines as fgfr kinase modulators

The invention relates to new quinoline derivative compounds of formula (i), to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. Cancer..
Astex Therapeutics Limited

Benzoquinoline inhibitors of vesicular monoamine transporter 2

The present invention relates to new benzoquinoline inhibitors of vesicular monoamine transporter 2 (vmat2), pharmaceutical compositions thereof, and methods of use thereof.. .
Auspex Pharmaceuticals, Inc.

Blue light polarization film and its manufacturing method, blue backlight and liquid crystal display device

Disclosed are a blue light polarization film and its manufacturing method, as well as a blue backlight and a liquid crystal display device. The blue light polarization film is of a multi-layered film formed by depositing magnesium aluminum hydrotalcite and tri(8-hydroxyquinoline-5-sulfoacid) aluminum alternately.
Beijing Boe Optoelectronics Technology Co., Ltd.

2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition

Various 2-aminoquinoline compounds as can be used, in vivo or in vitro, for selective inhibition of neuronal nitric oxide synthase.. .

Dupa-indenoisoquinoline conjugates

A targeting ligand-cytotoxic drug conjugate, for example, a dupa-indenoisoquinoline conjugate, is useful for treating cancers, e.g., prostate cancer.. .
Purdue Research Foundation

Benzoquinoline inhibitors of vesicular monoamine transporter 2

The present invention relates to new benzoquinoline inhibitors of vesicular monoamine transporter 2 (vmat2), pharmaceutical compositions thereof, and methods of use thereof.. .
Auspex Pharmaceuticals, Inc.

Oncogenic ros1 and alk kinase inhibitor

A compound suitable for treating cancer, in particular nsclc, inhibits activity of oncogenic ros1 kinase and alk kinase. The compound has certain structural components such as a quinoline moiety in the backbone and at least one phenyl-containing moiety in a side chain with a hydrophobic substituent attached to the backbone via an up to 6-membered linking group as well as a further hydrophobic moiety.
Macau University Of Science And Technology

Compositions comprising vitamin c, vitamin e, and coenzyme q10 and use thereof for promoting female fertility and reproductive health

A new composition including substances that prolong and enhance the quality of the female reproductive system; effectively reducing the physiological effects of aging of the female reproductive system. In some aspects, the composition of the present invention includes coenzyme q10, vitamin c, and vitamin e.
Fertilify Inc.

6-heteroaryloxy- or 6-aryloxy-quinoline-2-carboxamides and use

And pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein r1, r2, and r3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., nav1.7 and/or nav1.8. Methods for making the compounds are disclosed.

Process of preparing pharmaceutical compositions for the treatment of cftr mediated diseases

Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (compound 1) in form i and a solid dispersion comprising substantially amorphous n-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1h-quinoline-3-carboxamide (compound 2), methods of treating, lessening the severity of or symptomatically treating cftr mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed.. .
Vertex Pharmaceuticals Incorporated

Indenotriphenylene-based iridium complexes for organic electroluminescence device

Wherein a ring represents an imidazole, a pyridine, a quinoline and an isoquinoline, x1-x2 represents a bidentate ligand, and m, n and r1 to r4 are the same definition as described in the present invention.. .

Benzoquinoline inhibitors of vesicular monoamine transporter 2

The present invention relates to new benzoquinoline inhibitors of vesicular monoamine transporter 2 (vmat2), pharmaceutical compositions thereof, and methods of use thereof. (formula (i)).
Auspex Pharmaceuticals, Inc.

Combination therapy

Described herein are compounds and compositions for treating glaucoma and/or reducing intraocular pressure. Compositions may comprise an isoquinoline compound and a prostaglandin or a prostaglandin analog.
Aerie Pharmaceuticals, Inc.

Method of making a benzylisoquinoline alkaloid (bia) metabolite, enzymes therefore

There is provided a method of preparing a benzylisoquinoline alkaloid (bia) metabolite comprising: a. Culturing a host cell under conditions suitable for protein production, including a ph of between about 7 and about 10 said host cell comprising: b.
Valorbec SociÉtÉ En Commandite

Compounds, compositions and associated methods comprising 3-aryl quinolines

Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and methods of treating infectious diseases such as malaria, are disclosed..
The United States Government As Represented By The Department Of Veterans Affairs

Novel substituted quinoline compounds as s-nitrosoglutathione reductase inhibitors

The present invention is directed to novel quinoline compounds useful as s-nitrosoglutathione reductase (gsnor) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.. .
Nivalis Therapeutics, Inc.



Quinoline topics:
  • Isoquinolin
  • Praziquantel
  • Carbon Atoms
  • Crystallin
  • Quinoline Derivatives
  • Pharmaceutically Acceptable Salt
  • Alkyl Group
  • Cycloalkyl
  • Pharmaceutically Acceptable Salts
  • Immunodeficiency
  • Retrovirus
  • Viral Infection
  • Human Immunodeficiency Virus
  • Angiogenesis
  • Sulfonamide


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    This listing is a sample listing of patent applications related to Quinoline for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Quinoline with additional patents listed. Browse our RSS directory or Search for other possible listings.


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