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Quinoline

Quinoline-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Tetrahydroisoquinoline derivatives
Cytokinetics, Incorporated
August 17, 2017 - N°20170233402

Novel tetrahydroisoquinoline derivative compounds are disclosed herein that may be used as an active ingredient for a pharmaceutical composition, and in particular, for a pharmaceutical composition useful for preventing or treating a disease or condition responsive to modulation of the contractility of the skeletal sarcomere. This may be accomplished, for example, by modulation of the troponin complex of the fast ...
NEW Substituted quinoline-4-carboxamides and use thereof
Bayer Pharma Aktiengesellschaft
August 17, 2017 - N°20170233345

The present application relates to novel substituted quinoline-4-carboxamides and use thereof, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
NEW High-purity quinoline derivative and method for manufacturing same
Eisai R&d Management Co., Ltd.
August 17, 2017 - N°20170233344

Provided is a compound represented by formula (iv) or a salt thereof, wherein the content of the compound represented by formula (i) is 350 ppm by mass or less.
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NEW Quinoline containing compounds and their use for treating endoplasmic reticulum stress-related diseases
Astellas Ireland Co., Ltd.
August 17, 2017 - N°20170231973

Provided herein are quinoline, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of an endoplasmic reticulum stress-caused disease. Also provided herein are methods of their use for reducing endoplasmic reticulum stress and modulating the activity of a sarcoplasmic/endoplasmic reticulum ca2+atpase.
NEW Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
Vertex Pharmaceuticals Incorporated
August 17, 2017 - N°20170231970

The present invention relates to solid state forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (compound 1), pharmaceutical compositions thereof and methods therewith.
New dihydroquinoline pyrazolyl compounds
Vertex Pharmaceuticals Incorporated
August 10, 2017 - N°20170226116

Wherein r1, r2, r3, r4, r5, r6, r7, r8, r10, r11, r12, r13, r14, r15, r16, r17 and m are as described herein, compositions including the compounds and methods of using the compounds.
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Quinoline Patent Applications
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  • 195+ full patent PDF documents of Quinoline-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Dihydroquinoline pyrazolyl compounds
Vertex Pharmaceuticals Incorporated
August 10, 2017 - N°20170226085

Wherein r1, r2, r3, r4, r5, r6, r7, r8, r9, r10, r11, r12, r13, r14, r15, r16, r17, m and n are as described herein, compositions including the compounds and methods of using the compounds.
Dihydroquinoline pyrazolyl compounds
Vertex Pharmaceuticals Incorporated
August 10, 2017 - N°20170226079

Wherein r1, r2, r3, r4, r5, r6, r7, r8, r9, r15, r16, r17 and n are as described herein, compositions including the compounds and methods of using the compounds.
Crystal form of quinoline compound and process for its production
Vertex Pharmaceuticals Incorporated
August 10, 2017 - N°20170226061

The water content is adjusted to a level of from 5 to 15%, and the crystal form is controlled to be crystal form a, thereby to obtain a drug substance excellent in stability.
Coformer salts of (2s,3s)-methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1h-1,2,4-triazol-5-yl)...
Medivation Technologies, Inc.
August 03, 2017 - N°20170217921

Described herein are coformer salts of (2s,3s)-methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1h-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate optionally as a solvate and additionally optionally as a hydrate, including crystalline forms, and methods of preparing the (2s,3s)-methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1h-1, 2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate optionally as a coformer ...
Crystalline free bases of c-met inhibitor or crystalline acid salts thereof, and preparation methods and ...
Jiangsu Hansoh Pharmaceutical Group Co., Ltd.
July 27, 2017 - N°20170210760

Crystalline free bases and crystalline acid salts of 9-((8-fluoro-6-(1-methyl-1h-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridine-3-yl)thio)-4-methyl-2h-[1,4]oxaazido [3,2-c]quinoline-3(4h)-one are disclosed as c-met inhibitors. Their preparation methods and uses are also described. In particular, crystal forms i, ii, iii and iv of the free base; crystal form i of the hydrochloride ...
Phenyl tetrahydroisoquinoline compound substituted with heteroaryl
Jiangsu Hansoh Pharmaceutical Group Co., Ltd.
July 27, 2017 - N°20170210736

Y represents a hydrogen atom or a structure represented by the following formula [3′]:
Aminoquinoline derivatives and uses thereof
The Mclean Hospital Corporation
July 27, 2017 - N°20170209441

Described herein are aminoquinoline and aminoacridine based hybrids, pharmaceutical compositions and medicaments that include such aminoquinoline and aminoacridine based hybrids, and methods of using such compounds for diagnosing and/or treating infections, neurodegenerative diseases or disorders, inflammation, inflammation associated diseases and disorders, and/or diseases or disorders that are treatable with dopamine agonists such as the restless leg syndrome.
Quinoline Patent Pack
Download 195+ patent application PDFs
Quinoline Patent Applications
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For professional research & prior art discovery
inventor
  • 195+ full patent PDF documents of Quinoline-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Quinoline derivatives for the treatment of inflammatory diseases
Universite De Montpellier
July 20, 2017 - N°20170204063

The present invention relates to a compound of formula (i) wherein: formula (ii) means an aromatic ring wherein v is c or n and when v is n; q is n or o, provided that r″ does not exist when q is o; r′ independently represent a hydrogen atom or a group chosen among a (c1-c3)alkyl ...
Polyketal particles including a cpg oligodeoxynucleotide for the treatment of lung cancer
Universite De Montpellier
July 20, 2017 - N°20170202977

The methods include locally administering to the subject a therapeutically effective amount of the polyketal particle comprising a cpg oligodexoynucleotide. Optionally, the polyketal particle can include an imidazoquinoline compound.
Methods and uses of quinoline derivatives in the treatment of soft tissue sarcomas and pharmaceutical ...
Advenchen Laboratories Nanjing Ltd
July 20, 2017 - N°20170202828

The present invention addresses methods and uses of quinoline derivatives in the treatment of tumours and pharmaceutical compositions for treatment of same. Specifically, the present invention involves a method and applications for the use of the quinoline derivative 1-[[[4-(4-fluoro-2-methyl-1h-indol-5-yl)oxy-6-methoxyquinolin-7-yl]oxy]methyl]cyclopropylamine in the treatment of soft tissue sarcomas and pharmaceutical compositions ...
Methods of manufacturing benzoquinoline compounds
Auspex Pharmaceuticals, Inc.
July 13, 2017 - N°20170197957

The present invention relates to new methods of manufacturing benzoquinoline inhibitors of vesicular monoamine transporter 2 (vmat2), and intermediates thereof.
A quinoline derivative for the treatment of inflammatory diseases and aids
Universite De Montpellier
July 13, 2017 - N°20170197938

The present invention relates to a compound of formula (1) in the form of a base or addition salt with an acid, particularly a pharmaceutically acceptable acid. It further relates to a pharmaceutical composition including the compound and at least one pharmaceutically acceptable excipient, to a process for preparing said compound and to a corresponding intermediate compound.
Enantiomers of 8-hydroxyquinoline derivatives and the synthesis thereof
Universite De Montpellier
July 13, 2017 - N°20170197936

The subject matter of the invention furthermore relates to a novel, stereoselective synthesis for the preparation of the novel enantiomer derivatives according to the invention. The novel medicinal and/or pharmaceutical compositions comprising these enantiomers are suitable for the treatment of the named diseases, and the enanatiomers are used for manufacture of these compositions. These applications for manufacture of the ...
Heterocyclic gsk-3 allosteric modulators
Consejo Superior De Investigaciones Cientificas (csic)
July 13, 2017 - N°20170196850

The present invention relates to heterocyclic substituted quinoline derivatives as allosteric inhibitors of the glycogen synthase kinase-3 (gsk-3) enzyme. Therefore, these compounds are useful for the manufacturing of a medicament designed for the treatment and/or prevention of diseases wherein gsk-3 is involved, such as neurodegenerative diseases, inflammatory diseases, cancer, diabetes, and to promote various regenerative processes.
Redoxindicators
Roche Diagnostics Operations, Inc.
July 06, 2017 - N°20170191990

The present invention relates to a chemical compound or a salt or solvate thereof being a phenazine-, phenanthridine-, phenanthroline-, quinoline-, quinoxaline-, acridine- isoquinoline-, pyrazine- or pyridine-derivative comprising a conjugated π-system and a π-acceptor group, and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the chemical compound ...
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