Quinoline

Quinoline-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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Crystalline form of a substituted quinoline compound and pharmaceutical compositions thereof
Calitor Sciences, Llc
May 18, 2017 - N°20170137404

The present invention relates to a crystalline form of n-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide p-toluenesulfonate, the process for preparing the crystalline form thereof, and pharmaceutical compositions comprising the crystalline form thereof. This invention also relates to a method of using such a crystalline form in the treatment of ...
Isoquinoline compounds, a process for their preparation, and pharmaceutical compositions containing them
Calitor Sciences, Llc
May 18, 2017 - N°20170137385

Medicinal products containing the same which are useful in treating or preventing pathologies which are the result of activation of the rhoa/rock pathway and phosphorylation of the myosin light chain.
Method of treating a viral infection using elvitegravir combinations
Gilead Sciences, Inc.
May 18, 2017 - N°20170136001

The invention includes methods, compositions, and kits useful for treating a viral infection by administering 6-(3-chloro-2-fluorobenzyl)-1-[(2s)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or a pharmaceutically acceptable salt thereof, with atazanavir or a pharmaceutically acceptable salt thereof, and optionally with a compound that inhibits cytochrome p-450, or a pharmaceutically acceptable salt thereof.
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Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
3m Innovative Properties Company
May 11, 2017 - N°20170129891

Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
Amino-quinolines as kinase inhibitors
3m Innovative Properties Company
May 11, 2017 - N°20170128437

Wherein r1, r2, r3 and z are as defined herein, and methods of making and using the same.
Combination drug therapies for cancer and methods of making and using them
Vicus Therapeutics, Llc
May 11, 2017 - N°20170128417

In alternative embodiments, provided are therapeutic combinations, pharmaceutical compositions, formulations, kits and devices for treating, preventing or ameliorating a tumor or a cancer, and methods for treating, preventing or ameliorating a tumor or a cancer. In alternative embodiments, provided are therapeutic combinations, pharmaceutical compositions, formulations, kits and devices comprising: a beta adrenergic receptor antagonist (a “beta blockerȁ...
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Process and intermediates for the synthesis of (r)-praziquantel
Tongli Biomedical Co., Ltd.
May 04, 2017 - N°20170121330

The present disclosure relates to a process and new intermediates for the synthesis of (r)-praziquantel, which is obtained through four steps in proper order, that is, condensation reaction, reduction reaction, acylation reaction and ring-closing reaction, using (1r)-2-substituted-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid as starting material. Overall, the present disclosure provides a (r)-praziquantel product with higher optical purity through ...
Method of making a liquid composition
Braingear Enterprises, Inc.
May 04, 2017 - N°20170119836

Methods of making liquid compositions that can be used, for example, to improve human health, and in particular brain health are provided. The l-theanine is solubilized in water prior to the addition of other ingredients, such as acetyl-l-carnitine, choline bitartrate, inositol, n-acetyl l-tyrosine and pyrroloquinoline quinone (pqq). In some embodiments, additional ingredients such as dmae bitartrate, vitamin d, niacin, vitamin ...
Hexahydrodiazepinoquinolines carrying a substituted alkyl radical
Abbvie Deutschland Gmbh & Co. Kg
April 27, 2017 - N°20170112851

The present invention relates to tricyclic hexahydrodiazepinoquinolines carrying a substituted alkyl radical, to a method for producing them, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-ht2c receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation ...
8-(piperazin-1-yl)-1,2,3,4-tetrahydro-isoquinoline derivatives
Actelion Pharmaceuticals Ltd
April 20, 2017 - N°20170107214

The invention relates to compounds of formula (i) wherein r1, r2, r3, r4 and r5 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the cxcr3 receptor.
Novel quinoline-substituted compound
Actelion Pharmaceuticals Ltd
April 13, 2017 - N°20170101414

The present invention provides a compound represented by formula (i) below, or a salt thereof.
Therapeutic agent for ocular fundus disease
Kowa Company, Ltd.
April 13, 2017 - N°20170100409

Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (s)-(−)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient.
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Organic electroluminescent materials and devices
Universal Display Corporation
April 06, 2017 - N°20170098789

This invention discloses iridium complexes with ligands based on a phenyl quinoline backbone with at least a double substitution on the quinoline moiety. These complexes can be used as phosphorescent emitters in oleds.
Encapsulation of isoquinoline alkaloids
Rhizofeed, Llc
April 06, 2017 - N°20170095467

Processes of extracting isoquinoline alkaloids from natural sources and encapsulating the alkaloids in an alginate and inulin matrix are provided. The isoquinoline alkaloid encapsulates are useful as animal feed.
Pharmaceutical compositions comprising 7-(1h-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline for treating skin diseases and conditions
Allergan,inc.
April 06, 2017 - N°20170095466

The present invention relates to a method for treating skin diseases and skin conditions in a patient in need thereof which comprises of administering a therapeutically effective amount of a pharmaceutical composition comprising a therapeutically effective amount of 7-(1h-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline, or its individual enantiomers or the tautomers thereof, or a pharmaceutically acceptable salt thereof.
Selective androgen receptor degrader (sard) ligands and methods of use thereof
University Of Tennessee Research Foundation
April 06, 2017 - N°20170095446

This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (sard) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other hyper androgenic dermal diseases, kennedy's disease, amyotrophic lateral sclerosis (als), and uterine fibroids, and to methods for reducing the levels of androgen ...
Alkyloxy substituted thiazoloquinolines and thiazolonaphthyridines
3m Innovative Properties Company
March 30, 2017 - N°20170088559

Thiazoloquinolines and thiazolonaphthyridines with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
Quinoline derivative
Ono Pharmaceutical Co., Ltd.
March 30, 2017 - N°20170088542

A compound represented by general formula (i) has a strong axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon ring is fused to a pyridone ring, and can be a therapeutic agent for axl-related diseases, for example, cancer such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, ...
Superdegas- a process of integrating sulfur collection and degassing for zero emission
Ono Pharmaceutical Co., Ltd.
March 30, 2017 - N°20170088421

Superdegas process refers to innovative process of the liquid sulfur collection and degassing which takes place in the underground container in a concrete pit or a carbon steel vessel located in the concrete pit. Superdegas process consists of at least three compartments: (1) sulfur collection to agitate and create turbulent, higher velocity, and higher pressure in the liquid sulfur for more ...
Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
Auspex Pharmaceuticals, Inc.
March 30, 2017 - N°20170087147

The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (vmat2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.