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Quinoline

Quinoline-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Toll-like receptor-7 and -8 modulatory 1h imidazoquinoline derived compounds
The University Of Kansas
May 17, 2018 - N°20180134701

The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using such compounds. The present disclosure also provides tlr7 agonists and tlr7/tlr8 dual agonists, probes, tissue-specific molecules, adjuvants, immunogenic compositions, therapeutic compositions, and self-adjuvanting vaccines including the imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable ...
NEW Sodium salt of uric acid transporter inhibitor and crystalline form thereof
Jiangsu Hengrui Medicine Co., Ltd.
May 17, 2018 - N°20180134663

Provided are a sodium salt of a uric acid transporter inhibitor and a crystalline form thereof, in particular, provided are a uric acid transporter (urat1) inhibitor 1-((6-bromo-quinoline-4-yl)thio)cyclobutyl sodium formate (the compound of formula (i)), a crystal form i, and preparation method thereof. The obtained crystal form i of the compound of formula (i) has a good ...
Cyclopropyl unsaturated quinoline compound used as leukotriene receptor antagonist and applications thereof
May 03, 2018 - N°20180118687

An application of the compound or its pharmaceutically acceptable salts, hydrates, solvates, or prodrugs in preparing a drug for treating and/or preventing and/or delaying and/or providing adjuvant therapy for asthma and/or allergic rhinitis and asthma syndromes is provided. A drug composition includes the cyclopropyl unsaturated quinoline compound or the pharmaceutically acceptable salts, hydrates, solvates, or prodrugs ...
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Quinoline Patent Applications
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  • 195+ full patent PDF documents of Quinoline-related inventions.
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Spiro-isoquinoline-1,4'-piperidine compounds having multimodal activity against pain
Laboratorios Del Dr. Esteve S.a.
April 26, 2018 - N°20180111935

The present invention relates to spiro-isoquinoline-1,4′-piperidine compounds having dual pharmacological activity towards both the sigma (σ) receptor and the μ-opiod receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
Low emissions scorch inhibitor for polyurethane foam
Vanderbilt Chemicals, Llc
April 05, 2018 - N°20180094120

Disclosed is a scorch inhibitor composition comprising (a) one or more 2,2,4-trimethyl-1,2-dihydroquinoline compound, (b) one or more lactone, (c) one or more phenolic compound, (d) optionally one or more tocopherol, and (e) optionally one or more phosphite compound.
Isoquinolin-3-yl carboxamides and preparation and use thereof
Samumed, Llc
April 05, 2018 - N°20180093970

Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e. G., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by ...
Quinoline Patent Pack
Download 195+ patent application PDFs
Quinoline Patent Applications
Download 195+ Quinoline-related PDFs
For professional research & prior art discovery
inventor
  • 195+ full patent PDF documents of Quinoline-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Quinoline derivatives as inhibitors of heat shock factor 1 pathway activity
April 05, 2018 - N°20180093955

Wherein r, r4 and q are each as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 pathway (hsf1 pathway). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for ...
A specific trifluoroethyl quinoline analogue for use in the treatment of sjögren's syndrome
Ucb Biopharma Sprl
April 05, 2018 - N°20180092921

N-{(r)-1-[8-chloro-2-(1-oxypyridin-3-yl)-quinolin-3-yl]-2,2,2-trifluoroethyl}-pyrido[3,2-d]pyrimidin-4-ylamine is effective in the treatment and/or prevention of sjögren's syndrome.
Preparation of silica reinforced rubber composition, rubber composition and tire with component
The Goodyear Tire & Rubber Company
March 29, 2018 - N°20180086900

The invention relates to preparation of a precipitated silica reinforced rubber composition, a resulting rubber composition and tire with component comprised of such rubber composition. The invention relates to blending a pre-formed composite of pre-hydrophobated precipitated silica and fatty acid with a rubber composition and subsequently reacting zinc oxide therewith in situ within the rubber composition to form a zinc ...
Quinoline compounds
March 29, 2018 - N°20180086714

Wherein the variables are defined as given in the description and claims. The invention further relates to uses, processes and intermediates for compounds i.
Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
Axovant Sciences Gmbh
March 29, 2018 - N°20180085367

The combination of 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline or a pharmaceutically acceptable salt thereof with a second therapeutic agent, and its use for the treatment of a) psychiatric disorders with prominent cognitive deficits e. G. Chronic ptsd (post traumatic stress disorder); b) non-degenerative disorders with prominent cognitive deficits e. G. Ms (multiple sclerosis), post-chemotherapy, post-cabg (coronary artery bypass graft), post-stroke; and/or ...
Amino-quinolines as kinase inhibitors
March 29, 2018 - N°20180085365

Wherein r1, r2, r3 and z are as defined herein, and methods of making and using the same.
Condensed-cyclic compound and organic light-emitting device comprising the same
March 15, 2018 - N°20180076392

Wherein, in formulae 1, 2a, and 2b, ring a1 is selected from a benzene group, a naphthalene group, a pyridine group, a pyrimidine group, a pyrazine group, a quinoline group, an isoquinoline group, a quinoxaline group, a quinazoline group, and a cinnoline group; ring a2 is selected from a pyridine group, a pyrimidine group, a pyrazine group, a quinoline group, an ...
Quinoline Patent Pack
Download 195+ patent application PDFs
Quinoline Patent Applications
Download 195+ Quinoline-related PDFs
For professional research & prior art discovery
inventor
  • 195+ full patent PDF documents of Quinoline-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Crystal form of quinoline compound and process for its production
March 15, 2018 - N°20180072676

The water content is adjusted to a level of from 5 to 15%, and the crystal form is controlled to be crystal form a, thereby to obtain a drug substance excellent in stability.
Methods for meta-arylation of aromatic alcohols
The University Of Georgia Research Foundation, Inc
March 08, 2018 - N°20180065909

Provided are methods for the meta-selective c—h arylations of arene alcohol-based substrates. The methods combine the transient norbornene strategy with a quinoline-based acetal scaffold to achieve the formation of biaryl compounds. These processes establish a foundation for catalytic polyfunctionalization of alcohol-based compounds. The method comprises attaching a heterocyclic hemiacetal scaffold to an aromatic alcohol or a substituted aromatic ...
Methods for the treatment of abnormal involuntary movement disorders
Auspex Pharmaceuticals, Inc.
March 08, 2018 - N°20180064701

Disclosed herein are new dosage regimens for deuterium-substituted benzoquinoline compounds, and methods for the treatment of abnormal muscular activity, movement disorders, and related conditions.
Alkyloxy substituted thiazoloquinolines and thiazolonaphthyridines
3m Innovative Properties Company
March 01, 2018 - N°20180057509

Thiazoloquinolines and thiazolonaphthyridines with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
Isoquinoline amide and isoquinoline amide-substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating ...
Vanderbilt University
March 01, 2018 - N°20180057491

Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mglur4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
Beta-amino-isoquinolinyl amide compounds
Aerie Pharmaceuticals, Inc.
February 22, 2018 - N°20180050990

Disclosed are alpha-aryl-beta-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the invention are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular ...
2-oxo-3,4-dihydroquinoline compounds as plant growth regulators
Syngenta Participations Ag
February 15, 2018 - N°20180044297

The present invention relates to novel sulfonamide derivatives of formula (i), to processes and intermediates for preparing them, to plant growth regulator compositions comprising them and to methods of using them for controlling the growth of plants, improving plant tolerance to abiotic stress (including environmental and chemical stresses), inhibiting seed germination and/or safening a plant against phytotoxic effects of ...
Respiratory infection treating agent
February 15, 2018 - N°20180042918

[solution] a respiratory infection treating agent containing, as an active ingredient, 7-[(3s,4s)-3-{(cyclopropylamino)methyl}-4-fluoropyrrolidine-1-yl]-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or a pharmaceutically acceptable salt thereof.
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