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Quinoline

Quinoline-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Imidazo[4,5-c]quinolines as dna-pk inhibitors
Merck Patent Gesellschaft Mit Beschrankter Haftung
June 15, 2017 - N°20170166567

The invention relates to compounds of the formulae (i) and (ii) in which r1, r2, r3, r4, r5, r8, x and m have the meaning indicated in the claims, and/or physiologically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. The compounds of the formula (i) can be used for the inhibition of serine/threonine protein ...
Benzoquinoline inhibitors of vesicular monoamine transporter 2
Auspex Pharmaceuticals, Inc.
June 15, 2017 - N°20170166562

The present invention relates to new benzoquinoline inhibitors of vesicular monoamine transporter 2 (vmat2), pharmaceutical compositions thereof, and methods of use thereof.
Novel bisaminoquinoline compounds, pharmaceutical compositions prepared therefrom and their use
The Trustees Of The University Of Pennsylvania
June 15, 2017 - N°20170166530

The present invention relates to novel bisaminoquinoline compounds, pharmaceutical compositions comprising these novel compounds and methods for inhibiting autophagy in biological systems. Methods of treating cancer in patients in need using compounds and/or compositions according to the present invention alone or in combination with at least one additional anticancer agent represent additional aspects of the invention. Methods of treating ...
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Hexahydrodiazepinoquinolines carrying a cyclic radical
Abbvie Inc.
June 08, 2017 - N°20170158693

The present invention relates to tricyclic hexahydrodiazepinoquinolines carrying a cyclic substituent, to a method for producing them, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-ht2c receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5...
Method for preparing the anhydrous crystalline form of isoniazid-derived hydrazone, thus produced cristalline polymorph of ...
Abbvie Inc.
June 08, 2017 - N°20170158665

The present invention relates to the method for preparing the anhydrous crystalline form of isoniazid-derived hydrazone (8-hydroxyquinoline-2-carboxaldehyde isonicotinoyl hydrazone), to the thus produced polymorph and to the use thereof for the treatment of alzheimer's disease and parkinsonism, inter alia, and to a pharmaceutical composition.
4-(8-methoxy-1-((1-methoxypropan-2-yl)-2-(tetrahydro-2h-pyran-4-yl)-1 h-imidazo[4,5-c]quinolin-7-yl)...
Glaxosmithkline Llc
June 08, 2017 - N°20170157113

Novel quinoline compounds pharmaceutical compositions containing such compounds and their use in therapy.
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Quinoline Patent Applications
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  • 195+ full patent PDF documents of Quinoline-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Lubricant composition and lubricant composition-sealed bearing
Ntn Corporation
June 01, 2017 - N°20170152457

The present invention provides a lubricant composition which can be used as a lubricant for a rolling component, the composition capable of maintaining enhanced lubrication performance over a long period of time even under high temperature conditions such as temperatures of 180° c. Or higher, and a rolling bearing including the lubricant composition sealed therein. A lubricant composition-sealed bearing 1 includes ...
Methods for the treatment of abnormal involuntary movement disorders
Auspex Pharmaceuticals, Inc.
June 01, 2017 - N°20170151227

Disclosed herein are new dosage regimens for deuterium-substituted benzoquinoline compounds, and methods for the treatment of abnormal muscular activity, movement disorders, and related conditions.
Quinoline derivatives and their use for treating endoplasmic reticulum stress-related diseases and disorders
Auspex Pharmaceuticals, Inc.
June 01, 2017 - N°20170151225

Provided herein are quinolines, e. G., a compound of formula i, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of an endoplasmic reticulum stress-caused disease. Also provided herein are methods of their use for reducing endoplasmic reticulum stress and modulating the activity of a sarcoplasmic/endoplasmic reticulum ca2+ atpase.
Benzylisoquinoline alkaloids (bia) producing microbes, and methods of making and using the same
Auspex Pharmaceuticals, Inc.
May 25, 2017 - N°20170145454

Aspects of the invention include host cells that are engineered to produce benzylisoquinoline alkaloids (bias). The host cells include heterologous coding sequences for a variety of enzymes involved in synthetic pathways from starting compounds to bias of the host cell. Also provided are methods of producing the bias of interest by culturing the host cells under culture conditions that promote ...
Substituted pyrazino[2,2-a]isoquinoline derivatives
Auspex Pharmaceuticals, Inc.
May 25, 2017 - N°20170145010

The present invention relates to compounds of formula of formula i wherein r, r2and l are as described herein, compositions containing compounds of formula i, methods of manufacture of compounds of formula i and methods of treating psychiatric, metabolic, cardiovascular or sleep disorders with compounds of formula i.
Crystalline form of a substituted quinoline compound and pharmaceutical compositions thereof
Calitor Sciences, Llc
May 18, 2017 - N°20170137404

The present invention relates to a crystalline form of n-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide p-toluenesulfonate, the process for preparing the crystalline form thereof, and pharmaceutical compositions comprising the crystalline form thereof. This invention also relates to a method of using such a crystalline form in the treatment of ...
Isoquinoline compounds, a process for their preparation, and pharmaceutical compositions containing them
Calitor Sciences, Llc
May 18, 2017 - N°20170137385

Medicinal products containing the same which are useful in treating or preventing pathologies which are the result of activation of the rhoa/rock pathway and phosphorylation of the myosin light chain.
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Quinoline Patent Applications
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inventor
  • 195+ full patent PDF documents of Quinoline-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Method of treating a viral infection using elvitegravir combinations
Gilead Sciences, Inc.
May 18, 2017 - N°20170136000

The invention includes methods, compositions, and kits useful for treating a viral infection by coadministering 6-(3-chloro-2-fluorobenzyl)-1-[(2s)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or a pharmaceutically acceptable salt thereof, with lopinavir or a pharmaceutically acceptable salt thereof.
Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
3m Innovative Properties Company
May 11, 2017 - N°20170129891

Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
Amino-quinolines as kinase inhibitors
3m Innovative Properties Company
May 11, 2017 - N°20170128437

Wherein r1, r2, r3 and z are as defined herein, and methods of making and using the same.
Combination drug therapies for cancer and methods of making and using them
Vicus Therapeutics, Llc
May 11, 2017 - N°20170128417

In alternative embodiments, provided are therapeutic combinations, pharmaceutical compositions, formulations, kits and devices for treating, preventing or ameliorating a tumor or a cancer, and methods for treating, preventing or ameliorating a tumor or a cancer. In alternative embodiments, provided are therapeutic combinations, pharmaceutical compositions, formulations, kits and devices comprising: a beta adrenergic receptor antagonist (a “beta blockerȁ...
High rigidity rubber composition
Compagnie Generale Des Etablissements Michelin
May 04, 2017 - N°20170121507

Rubber compositions and rubber articles manufactured from such rubber compositions that include the well-known antioxidant poly-2,2,4-trimethyl-1,2-dihydroquinoline (tmq) having the formula (c12h15n) where n=2˜4 as well as a methylene acceptor/donor system reinforcing resin. Such embodiments include a tire component comprising a rubber composition that is based upon a cross-linkable elastomer composition, the cross-linkable rubber ...
Process and intermediates for the synthesis of (r)-praziquantel
Tongli Biomedical Co., Ltd.
May 04, 2017 - N°20170121330

The present disclosure relates to a process and new intermediates for the synthesis of (r)-praziquantel, which is obtained through four steps in proper order, that is, condensation reaction, reduction reaction, acylation reaction and ring-closing reaction, using (1r)-2-substituted-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid as starting material. Overall, the present disclosure provides a (r)-praziquantel product with higher optical purity through ...
Method of making a liquid composition
Braingear Enterprises, Inc.
May 04, 2017 - N°20170119836

Methods of making liquid compositions that can be used, for example, to improve human health, and in particular brain health are provided. The l-theanine is solubilized in water prior to the addition of other ingredients, such as acetyl-l-carnitine, choline bitartrate, inositol, n-acetyl l-tyrosine and pyrroloquinoline quinone (pqq). In some embodiments, additional ingredients such as dmae bitartrate, vitamin d, niacin, vitamin ...
Hexahydrodiazepinoquinolines carrying a substituted alkyl radical
Abbvie Deutschland Gmbh & Co. Kg
April 27, 2017 - N°20170112851

The present invention relates to tricyclic hexahydrodiazepinoquinolines carrying a substituted alkyl radical, to a method for producing them, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-ht2c receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation ...
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