Prothrombin Time patents
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|Microfabricated device with micro-environment sensors for assaying coagulation in fluid samples|
The present invention relates to sample analysis cartridges comprising micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using micro-environment sensors in a point of care sample analysis cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample, and a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber.
Abbott Point Of Care Inc.
|Fluid management system and methods|
A hysteroscopic fluid management system includes a saline source with an electrolyte concentration, at least one pressure mechanism for circulating saline to and from a targeted site and through a filter having filter characteristics back to the source, and a controller. The controller provides a saline inflow in a first flow path to the site and a saline outflow in a second flow path from the site through the filter and back to the source at a controlled flow rate.
|Device and measuring prothrombin time and hematocrit by analyzing change in reactance in a sample|
Devices and methods for measuring prothrombin time (pt) and hematocrit (hct) by analyzing the change in reactance in a sample are presented. A diagnostic device for measuring hct and pt of a fluid includes a relative electrode-type sensor device and a blood test card assembly including one or more pairs of electrodes, wherein alternating current (ac) provided by the sensor device is used to measure and calculate hct and pt of blood test using the reactance analysis..
Apex Biotechnology Corp.
|Procedure for biphasic preparation of liposomes and application thereof in manufacturing diagnostic reagents|
The invention relates to a procedure for biphasic preparation of liposomes, in the course of which technically simple and cheap mechanical mixing methods are used to commingle non-polar organic phase containing an individual mixture of natural and synthetic phospholipids and polar aqueous (buffer) phase not miscible with it, resulting in a liposome emulsion of a unique structure. Furthermore, the invention comprises embodiments of the procedure related to the in vitro diagnostic use of liposomes prepared in this way, when protein type active components are anchored to the surface of liposome membranes without application of any detergents and non-protein type active components are simply mixed with the liposome emulsion of a unique structure.
|Low volume assay apparatus|
Apparatus (1) for determining a property of a sample. The apparatus has a chamber (11, 13) for receiving at least a part of the sample and contains a rotor (15) adapted to rotate within the chamber (11, 13).
|Novel prognosis associated with cases of postpartum hemorrhage|
The present invention relates to an in vitro method of prognosis for the arrest of bleeding in a patient suffering from postpartum haemorrhage in the absence of an invasive procedure, comprising the following steps: (a) determining, using a biological sample from said patient, the plasma fibrinogen concentration, the blood troponin concentration and also the prothrombin time; (b) studying at least two clinical markers for said patient, selected from the group comprising heart rate and the presence of placentation abnormalities; (c) calculating a score z according to the following equation: z=a+b+v+d+e; where a is associated with the existence of placentation abnormalities in said patient, with a being 0 when no placentation abnormality is observed in said patient and a being 1 when one or more placentation abnormalities are observed in said patient; where b is associated with the heart rate of said patient, with b being 0 when the heart rate of said patient is less than or equal to 115 bpm (beats per minute) and b being 1 when the heart rate is greater than 115 bpm; where c is associated with the plasma fibrinogen concentration of said patient, with c being 0 when said concentration is greater than or equal to 2 g/l and c being 1 when said concentration is less than 2 g/l; where d is associated with the blood troponin concentration of said patient, with d being 0 when said concentration is less than the detection cut-off and d being 1 when said concentration is grater than or equal to the detection cut-off; where e is associated with the prothrombin time (pt) of said patient, with e being 0 when said prothrombin time is greater than or equal to 50% and e being 1 when said prothrombin time is less than 50%; where a score z of greater than or equal to a value of 2 is an indication of the need to perform an invasive procedure in order to stop the bleeding in said patient suffering from postpartum haemorrhage.. .
|Electrochemical blood test strips and diagnosis systems using the same|
Electrochemical blood test strips and diagnosis systems are presented. An electrochemical blood test strip for measuring hct % and prothrombin time includes an electrode plate having electrode circuit patterns on an insulator substrate; a separation plate disposed on the electrode plate defining a blood sample region, a channel and three reaction regions; and a cover plate disposed on the separation plate having a blood sample inlet and vents.
|Tetrakis[bis(dihydroxyphosphoryl)methyl]calixarene or its sodium salt thereof as fibrin polymerization inhibitors|
There is proposed a chemical compound of 5,11,17,23-tetrakis[bis(dihydroxyphosphoryl)methyl]calixarene and a sodium salt thereof, which can be used as antithrombotic agents. A highly specific inhibiting effect of the aforementioned calixarenes on the fibrin polymerization has been identified.
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