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Proteins patents

      

This page is updated frequently with new Proteins-related patent applications.




 Movable type method applied to protein-ligand binding patent thumbnailnew patent Movable type method applied to protein-ligand binding
Disclosed herein is a method of estimating the pose of a ligand in a receptor comprising identifying all possible atom pairs of protein-ligand complexes in a given configuration space for a system that comprises proteins; creating a first database and a second database; where the first database comprises associated pairwise distant dependent energies and where the second database comprises all probabilities that include how the atom pairs can combine; combining the first database with the second database via statistical mechanics to accurately estimate binding free energies as well as a pose of a ligand in a receptor; and selecting a protein-ligand complex for further study.. .
Board Of Trustees Of Michigan State University


 Method for the quantitative characterization of amyloid and/or aggregating peptides and/or proteins in a sample patent thumbnailnew patent Method for the quantitative characterization of amyloid and/or aggregating peptides and/or proteins in a sample
A method for the quantitative characterization of amyloid and/or aggregated peptides and/or proteins in a sample, comprising: providing a sample, wherein the sample includes an amyloid and/or aggregated peptide and/or protein having at least one aggregate size and shape; adding an active ingredient to be analyzed to the sample solution; separating the amyloid and/or aggregated peptides and/or proteins are from one another according to their aggregate size and shape; optionally completely denaturing the amyloid and/or aggregated peptides and/or proteins of a particular fraction into monomer building blocks; determining the change in concentration of the peptide and/or protein building blocks in at least one fraction by comparison against control values without the active ingredient.. .
Forschungszentrum JÜlich Gmbh


 Compositions and methods for analysis of protein sequences and post-translational modifications patent thumbnailnew patent Compositions and methods for analysis of protein sequences and post-translational modifications
The application discloses, compositions, methods, systems, and apparatuses for rapid sequence analysis of proteins, including location of post-translational modifications and disulfide bonds, is described. Limited digestion of fully denatured antibody occurs in seconds by flowing sample in 8 m urea at constant pressure through a micro column reactor containing immobilized aspergillopepsin i, resulting in a product mixture containing 3-10 kda peptides, which is then fractionated by capillary column chromatography and analyzed by both electron transfer dissociation (etd) and collision activated dissociation mass spectrometry.
University Of Virginia Patent Foundation


 Stepwise assembled capture compounds comprising a cleavable function and  isolating and/or characterizing biomolecules or biomolecule fragments, in particular proteins or protein fragments, of complex mixtures patent thumbnailnew patent Stepwise assembled capture compounds comprising a cleavable function and isolating and/or characterizing biomolecules or biomolecule fragments, in particular proteins or protein fragments, of complex mixtures
The invention relates to a process for isolating and/or characterising biomolecules and/or biomolecule fragments, in particular proteins and/or protein fragments, comprising the steps: provision of an immobilized compound ic through the interaction of a capture compound cc and the target compound t and a carrier compound ccb, carrying out a division step, in which a cleavable function f is cleaved, and a division compound dc is produced, and isolation and/or characterisation of said division compound dc. The invention relates further to a carrier compound ccb, a capture compound cc, a precursor compound pc and a division compound dc..
Caprotec Bioanalytics Gmbh


 Methods for diagnosing diseases associated with human signal peptide-containing molecules patent thumbnailnew patent Methods for diagnosing diseases associated with human signal peptide-containing molecules
The invention provides human signal peptide-containing proteins (hspp) and polynucleotides which identify and encode hspp. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists.
Incyte Corporation


 System and  analysis of protein migration in serum protein electrophoresis patent thumbnailnew patent System and analysis of protein migration in serum protein electrophoresis
A system and method for analyzing protein migration in serum protein electrophoresis is disclosed. A serum sample from a subject is collected and serum protein electrophoresis is performed to separate the plurality of proteins in the serum sample.

 Apparatus for analysing a molecule patent thumbnailnew patent Apparatus for analysing a molecule
An apparatus for analysing a molecule comprising:•a substrate;•at least one nanopore provided in the substrate;•first and second reservoirs separated by the substrate for respectively providing and receiving the molecule;•a controller to induce the molecule to move by from the first reservoir to the second reservoir via the nanopore;•at least one nanostructure arranged in the nanopore and/or around the nanopore on one side of the substrate for producing a localised electromagnetic field by plasmon resonance;•at least one coating provided in the substrate and/or on one side of the substrate for cooling the substrate and/or reflecting electromagnetic radiation incident thereon;;•a source of electromagnetic radiation arranged on the side of the substrate bearing the nanostructure(s) to induce plasmon resonance in each nanostructure and•a detector to detect signals produced by interaction of the electromagnetic field with the molecule as it passes through the nanopore. The apparatus is especially suitable for analysing biomolecules such as nucleic acids or proteins by raman spectroscopy..
Base4 Innovation Ltd


 Methods for producing virus particles with simplified glycosylation of surface proteins patent thumbnailnew patent Methods for producing virus particles with simplified glycosylation of surface proteins
Methods for production of virus particles with simplified glycosylation on structural or surface proteins are provided. When used as targets for vaccine production, the conserved nature of such sites generates vaccines that are less sensitive to viral mutations.
Academia Sinica


 Use of bile detergents to denature glycoproteins prior to enzymatic digestion patent thumbnailnew patent Use of bile detergents to denature glycoproteins prior to enzymatic digestion
Bile detergents can be used to denature glycoproteins prior to enzymatically deglycosylating the glycoproteins. Bile detergents, and especially bile salts, render glycans on a glycoprotein accessible to deglycosylation enzymes, especially the enzyme pngase f, and are compatible with the enzyme.

 Factors for the production and accumulation of polyunsaturated fatty acids (pufas) derived from pufa synthases patent thumbnailnew patent Factors for the production and accumulation of polyunsaturated fatty acids (pufas) derived from pufa synthases
Factors for the production and accumulation of polyunsaturated fatty acids (pufas) derived from pufa synthases abstract disclosed are novel enhancing factor proteins of the pufa synthase systems, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified microorganisms comprising the same, and methods of making and using the same. Also disclosed are genetically modified microorganisms that have been genetically modified to express a pufa synthase system for the production of pufas, wherein the microorganisms have been modified to express the novel enhancing factor proteins of the pufa synthase system..
Dsm Ip Assets B.v.


new patent

Methods of microalgae cultivation for increased resource production

Methods of inducing or increasing lipid and protein production in microalgae are disclosed. Methods of enhancing microalgae biomass are also disclosed.
Entech, Llc

new patent

Microscale bioprocessing protein manufacturing

A bioprocessing system for protein manufacturing is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The system can also be used for efficient on-demand production of any type of protein..
University Of Maryland Baltimore County

new patent

Protein coated polymeric substrate

The present invention provides a method for the functionalization of a polymeric surface with a protein by physical adsorption. The method enables a membrane spanning protein to be used as an anchor for proteins and/or peptides for display.
Orla Protein Technologies Limited

new patent

Antibodies against ox40 and uses thereof

Provided herein are antibodies, or antigen binding portions thereof, that bind to ox40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer.
Bristol-myers Squibb Company

new patent

Fusion proteins for modulating regulatory and effector t cells

The present invention provides fusion proteins that act on the glucocorticoid-induced tnfr family-related gene (gitr) and ox40 signaling pathway. In certain aspects, the proteins of the invention are useful in modulating both regulatory t (treg) cells and effector t (teff) cells..
The Trustees Of The University Of Pennsylvania

new patent

Prostate specific membrane antigen (psma) bispecific binding agents and uses thereof

Provided herein are isolated cd3×psma-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof wherein a fn3 domain specifically binds human prostate specific membrane antigen (psma) and a second antigen-binding site immunospecifically binds cd3. Also described are fusion proteins and related polynucleotides capable of encoding the provided fusion proteins and, cells expressing the provided fusion proteins.
Janssen Biotech, Inc.

new patent

Antibodies comprising chimeric constant domains

Antibodies, antigen-binding proteins and fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric fc-containing antibodies, antigen-binding proteins and fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric fc-containing proteins are provided..
Regeneron Pharmaceuticals, Inc.

new patent

Selective reduction of proteins

The present invention provides a method for making uncapped cysteine protein preparations, including uncapped engineered cysteine antibody preparations. The methods include, inter alia, contacting a reducing agent with engineered cysteine antibody molecules, each of the antibody molecules having at least one capped engineered cysteine residue and at least one interchain disulfide bond and reacting the reducing agent with the antibody molecules under conditions sufficient to uncap engineered cysteine residues and form cap byproducts.
Seattle Genetics, Inc.

new patent

P97 fusion proteins

Provided are p97 (melanotransferrin)-trastuzumab fusion proteins and related methods of use thereof, for instance, to facilitate delivery of trastuzumab across the blood-brain barrier (bbb) and/or improve tissue penetration of the antibody in cns and peripheral tissues, and thereby treat and/or diagnose her2-positive cancers, including those of the central nervous system (cns).. .
Bioasis Technologies, Inc.

new patent

Process for producing and purifying factor viii and its derivatives

Disclosed is a method for producing proteins having factor viii procoagulant activity in serum-free medium by in vitro culturing of mammalian cells, wherein the serum-free medium contains an inhibitor against the protease released from cultured cells. In accordance with this invention, the inhibitor can protect the cleavage of a target protein during cultivation and increase homogeneity of a target molecule, wherein the inhibitor can be a dextran sulfate.
Sk Chemicals Co., Ltd.

new patent

Fgfr-fc fusion proteins and the use thereof

The present invention belongs to the field of biotechnology and relates to the treatment of diseases, especially the treatment of fgf overexpression-related diseases. Particularly, the present invention relates to fgfr-fc fusion proteins and the use thereof in the treatment of angiogenesis regulation-related diseases.
Remegen, Ltd.

new patent

Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer

This invention relates to ly6g6f, vsig10, tmem25 and lsr proteins, which are suitable targets for immunotherapy, treatment of cancer, infectious disorders, and/or immune related disorders, and drug development. This invention further relates to soluble ly6g6f, vsig10, tmem25 and lsr molecules, extracellular domains of ly6g6f, vsig10, tmem25 and lsr and conjugates, which are suitable drugs for immunotherapy, treatment of cancer, infectious disorders, and/or immune related disorders.
Compugen Ltd.

new patent

Vstm5 polypeptides and uses thereof as a drug for treatment of cancer, infectious diseases and immune related diseases

This invention relates to vstm5 proteins, soluble molecules and fusions thereof which are suitable targets for drug development and for treatment of immune related disorders, immunotherapy, treatment of cancer, infectious disorders and/or sepsis.. .
Compugen Ltd.

new patent

Homogeneous preparations of il-31

Homogeneous preparations of human and murine il-31 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity..
Zymogenetics, Inc.

new patent

Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (crc) and other cancers

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer.
Immatics Biotechnologies Gmbh

new patent

Insecticidal proteins from plants and methods for their use

Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein.
E. I. Du Pont De Nemours And Company

new patent

Dihydropteridinone derivatives and uses thereof

The present invention provides compounds of formula (i), and pharmaceutically compositions thereof. Compounds of formula (i) are binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (bet) proteins).
Dana-farber Cancer Institute, Inc.

new patent

Diazepane derivatives and uses thereof

The present invention provides compounds of any one of formulae (i), (ii-c) (e.g., formula (ii)), and (iii), and pharmaceutically compositions thereof. Compounds of any one of formulae (i), (ii-c), and (iii) are believed to be binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (bet) proteins).
Dana-farber Cancer Institute, Inc.

new patent

Novel salts and co-crystals of lesinurad

Novel salts and cocrystals of lesinurad, processes for their preparation, pharmaceutical compositions comprising these new salt forms and co-crystals, and use of them for treating or delaying progression or onset of diseases or disorders related to activity of uric acid transport 1 (urat1) proteins are disclosed. These novel forms were characterized by x-ray powder diffraction, differential scanning calorimetry, and other techniques.
Suzhou Pengxu Pharmatech Co., Ltd.

new patent

Implant with improved surface properties

An implant for vascular implantation in a body is provided with a surface which, in the implanted state, is provided for contact with the body or with a bodily fluid and which is at least for the most part hydrated. The surface is advantageously provided as a bare metal surface of a chromium-containing alloy.
Qvanteq Ag

new patent

Biocompatible phase invertible proteinaceous compositions and methods for making and using the same

Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. The subject phase invertible compositions are prepared by combining a crosslinker and a proteinaceous substrate.
Mallinckrodt Pharma Ip Trading D.a.c.

new patent

Adhesive compounds and methods use for hernia repair

The invention describes new synthetic medical adhesives and films which exploit the key components of natural marine mussel adhesive proteins.. .
Kensey Nash Corporation

new patent

Compositions and methods to modulate cell activity

The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly.
The Rockefeller University

new patent

Modified glycolipids and methods of making and using the same

The invention is directed to compositions and methods related to proteins that are physically associated with ceramide-like glycolipids for use as activators of nkt cells. The compositions and methods of the present invention are useful for the prevention and treatment of diseases..
Albert Einstein College Of Medicine, Inc.

new patent

Type iii secretion injectisome proteins for treatment and prevention of chlamydial infections

Cpn0803, copb (cpn0809) and copd (cpn0808) proteins and homologues thereof are shown to induce an immune response that is protective against a live challenge with chlamydia. Methods and uses of cpn0803 or fragments or epitopes thereof alone or together with copb and/or copd or fragments or epitopes thereof for treating or preventing chlamydial infection in a subject in need thereof are provided..
Mcmaster University

new patent

Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (crc) and other cancers

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer.
Immatics Biotechnologies Gmbh

new patent

Epidermal growth factor receptor variant iii-mesothelin fusions and methods of using the same

Provided herein are compositions and methods for eliciting an immune response in a subject. In particular, the present disclosure is directed to fusion proteins comprising an epidermal growth factor receptor variant iii (egfrviii) polypeptide and a mesothelin polypeptide, and methods of eliciting an immune response using host cells comprising nucleic acid molecules encoding said fusion proteins.
Aduro Biotech, Inc.

new patent

Fusion proteins comprising factor ix for prophylactic treatment of hemophilia and methods thereof

The present invention relates to prophylactic dosing regimens with long-acting factor ix (fix) in dosing intervals of 1 week or longer, including (but not limited to) 10 days or longer, such as two weeks, three weeks or even monthly.. .
Csl Limited

new patent

Targeted oesophageal administration of zn-alpha2-glycoproteins (zag), methods and formulations thereof

The invention provides formulations and methods for ameliorating symptoms associated with metabolic disorders, such as hypoglycemia, obesity, diabetes, and the like by targeted administration to the oesphagus of a subject of zn-α2-glycoproteins or a functional fragment thereof, alone or in combination with additional agents, such as β adrenergin receptor agonists, β adrenergin receptor antagonists, and/or glycemic control agents.. .
Aston University

new patent

Chlamydomonas strains with chloroplast-expressed cry proteins for biological control of mosquitoes that transmit disease

The present invention relates to producing novel strains of green alga specifically engineered to produce an improved engineered compound over naturally occurring larvicide compound. In particular, genes were isolated and sequenced encoding naturally occurring larvicides produced by bti (bacillus thuringiensis subsp.
Board Of Regents, The University Of Texas System

Compositions and methods for quantitative assessment of dna-protein complex density

One aspect of the present invention describes materials and methods of quantitatively measuring the density or percent occupancy of dna binding proteins such as histones, histone variants, histone post translational modifications and transcription factors in chromatin at given dna loci. One embodiment measures a factor's average quantity at specific gene loci, and controls for a number of pitfalls concerning antibody quality and handling issues.
The University Of Chicago

Rapid protein labeling and analysis

The present invention provides methods and compositions for labeling, separating and analyzing proteins, particularly a specific protein of interest within a cell lysate or in a mixture of proteins. The proteins are labeled with an amine reactive or thiol reactive fluorescent dye, or an amine reactive fluorogenic reagent that becomes fluorescent upon reacting to amine groups located on the protein.
Life Technologies Corporation

Electrochemical immunosensor and use for analyte detection

A carbon nanofiber-based label free electrochemical immunosensor for sensitive detection of proteins in a fluid is described. The immunosensor as disclosed is a modified carbon nano-fiber screen printed electrode (cnf-spe) wherein the electrode is modified with a carboxyphenyl film and then activated by edc/nhs.
Universiti Brunei Darussalam

Multiple layer gel

A multiple layer gel and method for forming a multiple layer gel are provided. The multiple layer gel includes an isolation layer and an electrolyte layer.
Aytu Bioscience, Inc.

Size dependence of nanoparticle-protein interaction and high sensitivity potentiometric sensor exploiting such interactions

Fabrication of a high sensitivity potentiometric biosensor is described. The present inventors have developed and characterized a novel amplification platform using a gold nanoparticle (gnps) electrodeposition method.





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This listing is a sample listing of patent applications related to Proteins for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Proteins with additional patents listed. Browse our RSS directory or Search for other possible listings.


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