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Proteins patents



      

This page is updated frequently with new Proteins-related patent applications.




Date/App# patent app List of recent Proteins-related patents
04/07/16
20160097775 
 Methods and kits for detecting misfolded proteins patent thumbnailMethods and kits for detecting misfolded proteins
Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.. .
The Regents Of The University Of California


04/07/16
20160097768 
 Polyvalent chimeric ospc vaccinogen and diagnostic antigen patent thumbnailPolyvalent chimeric ospc vaccinogen and diagnostic antigen
Chimeric polyvalent recombinant proteins for use as vaccines and diagnostics for lyme disease (e.g. In canines and humans) are provided.
Virginia Commonwealth University


04/07/16
20160097749 
 Analyte mass spectrometry quantitation using a universal reporter patent thumbnailAnalyte mass spectrometry quantitation using a universal reporter
Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.. .

04/07/16
20160097081 
 Internalization of proteins into hollowed gold nanostructures patent thumbnailInternalization of proteins into hollowed gold nanostructures
Provided is a gold nanocage with pores, charged ligand molecules covalently bound to internal surfaces of the gold nanocage, and payload molecules electrostatically adsorbed onto said charged ligand molecules, wherein a pore diameter is between 1.2 and 20 times a gyration radius of the payload molecule. Also provided is a method for making a nanoparticle, including using polyvinylpyrrolidone as a capping agent in a galvanic replacement reaction to convert a silver nanocube into a gold nanocage having pores, replacing the polyvinylpyrrolidone on internal surfaces with charged ligand molecules, and electrostatically adsorbing payload molecules onto the charged ligand molecules, with a pore diameter less than twenty times a gyration radius of the payload molecule.
Rensselaer Polytechnic Institute


04/07/16
20160097059 
 Enhanced expression and stability regions patent thumbnailEnhanced expression and stability regions
Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (eesyrs) are provided for expression of a gene of interest in a eukaryotic cell.
Regeneron Pharmaceuticals, Inc.


04/07/16
20160097053 
 Yeast promoters from pichia pastoris patent thumbnailYeast promoters from pichia pastoris
In accordance with the invention, isolated nucleic acids, expression methods, host cells, expression vectors, and dna constructs for producing proteins, and proteins produced using the expression methods are described. More particularly, nucleic acids isolated from pichia pastoris wherein the nucleic acids have promoter activity are described.
Keck Graduate Institute Of Applied Life Sciences


04/07/16
20160097050 
 Devices and methods for display of encoded peptides, polypeptides, and proteins on dna patent thumbnailDevices and methods for display of encoded peptides, polypeptides, and proteins on dna
A novel method for displaying proteins and peptides is disclosed in which individual proteins or peptides remain associated with the dna encoding them. Proteins or peptides can be generated by in vitro translation of dna templates, either free in solution or arrayed on a solid support, such that the proteins or peptides remain immobilized on their dna templates.
The Board Of Trustees Of The Leland


04/07/16
20160097044 
 Antimicrobial enzyme fusions reduce resistance and kill intracellular staphylococcus aureus patent thumbnailAntimicrobial enzyme fusions reduce resistance and kill intracellular staphylococcus aureus
Multi-drug resistant bacteria are a persistent problem in modern health care, food safety and animal health. There is a need for new antimicrobials to replace over-used conventional antibiotics.
The United States Of America, As Represented By The Secretary Of Agriculture


04/07/16
20160097031 
 Compositions of active wnt protein patent thumbnailCompositions of active wnt protein
Compositions of purified biologically active wnt proteins are provided. Wnt proteins are found to be hydrophobic and post-translationally modified by addition of a lipid moiety at a conserved cysteine residue.
The Board Of Trustees Of The Leland Stanford Junior University


04/07/16
20160096935 
 Protein films and methods of forming the same patent thumbnailProtein films and methods of forming the same
Various embodiments disclosed relate to protein films and methods of making the same. In various embodiments, the present invention provides a method of making a protein film including placing on a substrate a protein solution, to form a precursor protein film.

04/07/16
20160096894 

Antibodies to insulin-like growth factor i receptor


The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor i receptor (igf-ir), which is preferably human igf-ir. The invention also relates to human anti-igf-ir antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins.
Amgen Fremont Inc.


04/07/16
20160096879 

Viscosity-reducing excipient compounds for protein formulations


The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions..
Reform Biologics, Llc


04/07/16
20160096876 

Compositions and methods of treating disease with fgfr fusion proteins


The invention provides fgfr fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The fgfr fusion molecules can be made in cho cells and may comprise deletion mutations in the extracellular domains of the fgfrs which improve their stability.
Five Prime Therapeutics, Inc.


04/07/16
20160096873 

Peptidomimetic macrocycles


The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides..
Aileron Therapeutics, Inc.


04/07/16
20160096872 

Methods for producing peptides using engineered inteins


The present invention provides a method for producing peptides by recombinant means. The peptides are expressed as part of a fusion protein comprising the target peptide and an engineered intein.
Novo Nordisk A/s


04/07/16
20160096036 

Light-activated cation channel and uses thereof


The present invention provides compositions and methods for light-activated cation channel proteins and their uses within cell membranes and subcellular regions. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-activated cation channels to specific cells or defined cell populations.
The Board Of Trustees Of The Leland Stanford Junior University


04/07/16
20160096035 

System and optogenetic therapy


Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations.
Circuit Therapeutics, Inc.


04/07/16
20160096034 

System and optogenetic therapy


Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations.
Circuit Therapeutics, Inc.


04/07/16
20160095954 

Fibrin microthreads


Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., rgd-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells.
Worcester Polytechnic Institute


04/07/16
20160095942 

Carrier-antibody compositions and methods of making and using the same


Described herein are compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic. Also described are lyophilized compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic..
Mayo Foundation For Medical Education And Research


04/07/16
20160095924 

Amino lipids and methods for the delivery of nucleic acids


The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo.
Tekmira Pharmaceuticals Corporation


04/07/16
20160095917 

Dps fusion proteins for use in vaccines and diagnostics


Novel nanoparticle fusion proteins comprising proteins or peptides fused to dps (dna binding protein from starved cells) proteins are provided which bring forth distinct advantages for development of new and improved vaccines, diagnostic tests, and other biomedical products.. .
Kj Biosciences Llc


04/07/16
20160095910 

Self-assembling synthetic proteins


The present disclosure provides for a synthetic immunogenic protein for use as an immuno-modulatory agent to enhance mammalian immune reactions towards conjugated protein or peptide containing antigens that are otherwise poorly immunogenic, including but not limited to self-antigens. The chimeric immunogenic proteins of the present disclosure can be used in the treatment of many illnesses, including but not limited to cancers, infectious disease, autoimmune disease, allergies and any clinical indication involving or affected by the immune response of a mammalian host..

04/07/16
20160095907 

Plant cell culture expressing human lysosomal proteins and uses thereof


A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an er signal and/or by-passing the golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells.
Protalix Ltd.


04/07/16
20160095901 

Lipoprotein complexes and manufacturing and uses thereof


The present disclosure relates to lipoprotein complexes and lipoprotein populations and their use in the treatment and/or prevention of dyslipidemic diseases, disorders, and/or conditions. The disclosure further relates to recombinant expression of apolipoproteins, purification of apolipoproteins, and production of lipoprotein complexes using thermal cycling-based methods..
Cerenis Therapeutics Holding S.a.


04/07/16
20160095881 

Promoting muscle building and repair and treating disorders related to collagen and pertinent proteins by using shilajit


A method of using shilajit or its individual components, or a combination of two or more of these components, to induce the body of a mammal, including that of a human, to synthesize new collagen and the related extracellular matrix proteins, thus promoting the health of all of the tissues and organs containing collagen and the related extracellular matrix proteins, including skin, connective tissue, muscle, cartilage, bone, and teeth and improve muscle building and regeneration, and/or treat collagen-related disorders is presented.. .
Natreon, Inc.


04/07/16
20160095815 

Substance for restoring normal co-expression and interaction between the lox and nrage proteins


The invention relates to the use of a substance for restoring normal co-expression and interaction between the lox and nrage proteins. The invention relates in particular to the use of an effective amount of at least one substance that modulates the expression and/or activity of the lox of seq id no: 1 and/or that modulates the expression and/or activity of the nrage of seq id no: 2 for modulating the interaction between the lox and nrage proteins to regulate the balance between the cellular proliferation, differentiation and apoptosis, particularly in cases where the balance between these phenomena is disturbed, and especially in cases where the interaction between lox and nrage is absent or altered.
Université Claude Bernard Lyon 1


04/07/16
20160095316 

Compositions and methods for the removal of biofilms


Methods of breaking down a biofilm or inhibiting, preventing or treating a microbial infection that produces a biofilm are disclosed, which involves administration of a polypeptide that has one or more hmg-box domains to a subject suffering from the infection or having the biofilm. By competing with microbial proteins that bind to dna scaffold in the biofilm, these polypeptides destabilize the biofilm leading to destruction and removal of the biofilm by the immune system..

04/07/16
20160095313 

Antimicrobial compositions and methods


The present invention is generally related to a product and process to reduce the microbial contamination on organic matter, such as processed meat, fruits and vegetables, plant parts, inanimate surfaces such as textiles and stainless steel, and in the mouth or on dental products. In particular, the invention is related to a product and process to disinfect surfaces using an antimicrobial composition containing an antimicrobial lipid, an enhancer selected from the group consisting of bacteriocins, antimicrobial enzymes, sugars, sugar alcohols, iron-binding proteins and derivatives thereof, siderophores, and combinations thereof, and optionally a surfactant..
3m Innovative Properties Company


03/31/16
20160091518 

Systems and methods for detection and quantification of analytes


Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component.
Cue Inc.


03/31/16
20160090615 

Method for producing natively folded proteins in a prokaryotic host


The present invention relates to a method for producing a protein of interest containing one or more disulfide bonds in its native state. The method comprises that a prokaryotic host cell is genetically engineered to express the protein of interest and a sulfhydryl oxidase in the cytoplasm of the host cell.
University Of Oulu


03/31/16
20160090577 

Heterologous expression of glycine n-acyltransferase proteins


The present disclosure provides novel compositions and methods for the production and use of polynucleotide sequences encoding a glycine n-acyltransferase protein (glyat, glyatl 1, glyatl 2, and glyatl 3) for the biosynthesis of n-acylglycine biosurfactants within a heterologous expression system.. .
Dow Agrosciences Llc


03/31/16
20160090571 

Culture media and methods for culturing microorganisms


Methods and culture media for culturing a microorganism associated with morgellons disease are provided. In exemplary embodiments, methods are provided that may include adding a microorganism associated with morgellons disease to a solution containing ferrous iron, sugar and water or to a solid growth medium containing agar and ferrous iron.
Orior, Llc


03/31/16
20160090418 

Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies


Provided are methods for optimizing therapy of, treating a patient having, or selecting (identifying) patients who will benefit from treatment for, a cancer (e.g., a non-hematological cancer; e.g., a gynecological cancer). The methods comprise determining whether the patient will benefit from treatment with an erbb3 inhibitor (e.g., an anti-erbb3 antibody), with or without either a taxane or an aromatase inhibitor, or with a taxane or an aromatase inhibitor in the absence of an erbb3 inhibitor, based on levels of particular biomarkers and combinations of biomarkers measured in a biological sample obtained from the patient.
Merrimack Pharmaceuticals, Inc.


03/31/16
20160090415 

Methods to produce particles comprising therapeutic proteins


The present invention relates to methods for producing a particle comprising a polymer matrix and a protein.. .
Ucb Biopharma Sprl


03/31/16
20160090414 

Binding proteins specific for insulin-like growth factors and uses thereof


Binding proteins, such as antibodies directed to igf-ii with cross-reactivity to igf-i and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the igf-ii with cross-reactivity to igf-i are disclosed.
Medimmune Limited


03/31/16
20160090411 

Nucleic acid and corresponding protein named 158p1d7 useful in the treatment and detection of bladder and other cancers


The invention described herein relates to novel nucleic acid sequences and their encoded proteins, referred to as 158p1d7 and variants thereof, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express 158p1d7 and variants thereof.. .
Agensys, Inc.


03/31/16
20160090410 

Fucosylation-deficient cells


An isolated nucleic acid encoding an fx protein having a serine at position 79, a lysine at position 90, a leucine at position 136, an arginine at position 211, a serine at position 289, and a combination thereof is provided. Cells having a gene encoding a modified fx protein are provided, wherein the cells exhibit a reduced ability to fucosylate a glycoprotein at a first temperature, but exhibit the ability to fucosylate the glycoprotein at a second temperature.
Regeneron Pharmaceuticals, Inc.


03/31/16
20160090407 

Interleukin-2 fusion proteins and uses thereof


The present invention generally relates to fusion proteins of immunoglobulins and interleukin-2 (il-2). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides.
Roche Glycart Ag


03/31/16
20160090406 

Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof


The invention relates to neuromodulatory oligomers of the amyloid-β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents.
Abbvie Deutschland Gmbh & Co. Kg


03/31/16
20160090404 

Modified biotin-binding protein, fusion proteins thereof and applications


The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins comprising the modified biotin-binding protein and an antigen.
Children's Medical Center Corporation


03/31/16
20160090400 

Antibody like protein


A general method and recombinant nucleic acid sequences, by means which the method selects a recombinant protein containing an fha domain for binding a target molecule from a library proteins with a high-throughput method of creating protein variations within the fha domain in non-conserved or non-structural sequences of the fha scaffold, and the library may also be in the form of a phagemid or phage library wherein the alp nucleic acid sequence is inserted into a vector capable of allowing the vector and expressed alp protein from being virally packaged, and the recombinant nucleic acid sequences which are randomly mutated at varying non-conserved or non-structural fha domain sequences.. .

03/31/16
20160090345 

Fatty acid metal salt for forming ultrafine metal particles


A method of producing a powder of fatty acid metal salt for forming ultrafine metal particles includes washing the fatty acid metal salt so that the amount of unreacted substance or by-product is 4.0 mol % or less when the fatty acid metal salt is formed; preparing a pressed cake by pressing the fatty acid metal salt; and drying the pressed cake so that the water content is 200 ppm or less. The powder has a property for deodorizing mercaptan smelling components and/or a property for inactivating microproteins..
Toyo Seikan Kaisha, Ltd.


03/31/16
20160089445 

Derivatisation of biological molecules


The polymers are particularly suitable for derivatising proteins, such as interferon-α.. .

03/31/16
20160089422 

Method for inactivating a prion protein


The invention relates to a process for inactivating pathological prion proteins (prpsc) in a sample or a material which may be contaminated by a pathological prion protein, wherein the sample or the material which may be contaminated by a pathological prion protein is put into contact with at least one methionine sulfoxide reductase.. .
Laboratoire Francais Du Fractionnement Et Des Biotechnologies


03/24/16
20160084860 

Multifunctional protein molecular weight ladders


Multifunctional molecular weight protein ladders and methods of making thereof are disclosed herein that are useful for determining the molecular weight of a test protein and/or the relative mass or amount of the test protein in a protein separation assay, such as gel electrophoresis or western blotting. Also included are compounds of formula i (e.g., mono acetylated mp-11 nhs ester) that may be used to label purified proteins of the protein ladder.
Li-cor,inc.


03/24/16
20160084845 

Compositions and methods for detecting s-nitrosylation and s-sulfinylation


The present invention relates to methods for detecting protein s-sulfinylation and s-sulfinylation within thiol groups in proteins, metabolites, or materials.. .
The Regents Of The University Of Michigan


03/24/16
20160083803 

Methods and materials for detecting colorectal neoplasm


The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals having a colorectal neoplasm by detecting the presence of exfoliated epithelial markers (e.g., human dna, tumor assoicated gene alterations, tumor associated proteins) and blood markers (e.g., homoglobin, serum proteins) in a stool sample obtained from the mammal..
Mayo Foundation For Medical Education And Research


03/24/16
20160083786 

In situ interaction determination


Methods, reagents, compositions, and kits for in situ interaction determination (isid) via interaction-dependent polymerase chain reaction (id-pcr) are provided herein. Isid technology is useful for rapidly evaluating potential small molecule-target interactions from mixtures in a single solution.
President And Fellows Of Harvard College


03/24/16
20160083785 

Target detection and signal amplification


The present invention relates to compositions and methods for the detection of target molecules, and the amplification of detectable signals generated by detection assays. More specifically, the present invention relates to methods utilizing catalytic nucleic acid enzymes to generate and/or amplify a signal indicative of the presence of target molecules (e.g.
Speedx Pty Ltd


03/24/16
20160083781 

Integrated sample processing system


An integrated sample purification system includes a housing, a sample container rack, a filter holder, and a cylindrical magnet. The sample container rack and the filter device holder are disposed in the housing.
Akonni Biosystems, Inc.


03/24/16
20160083780 

Recombinase polymerase amplification


This disclosure describes related novel methods for recombinase-polymerase amplification (rpa) of a target dna that exploit the properties of recombinase and related proteins, to invade double-stranded dna with single stranded homologous dna permitting sequence specific priming of dna polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes, thus offering easy and affordable implementation and portability relative to other amplification methods.
Alere San Diego, Inc.


03/24/16
20160083763 

Method of random circular permutation by mucp-isc and mucp-issc transposons


A method for designing circular permuted proteins using two engineered mu transposons for easy construction of random circular permuted proteins, the two designed transposons being mucp-isc (mu circular permutation transposon with integrated start codon) and mucp-issc (mu circular permutation transposon with integrated start and stop codon).. .
New York University


03/24/16
20160083758 

Acyl-acp thioesterases and mutants thereof


Novel plant acyl-acp thioesterase genes of the fatb and fata classes and proteins encoded by these genes are disclosed. The genes are useful for constructing recombinant host cells having altered fatty acid profiles.
Solazyme, Inc.


03/24/16
20160083757 

Enzymatic process for the production of mannosylerythritol lipids from lignocellulosic materials


The present invention relates to processes for the production of microbial glycolipids, mannosylerythritol lipids (mel), from lignocellulosic carbon source. These processes are characterized in that the use of lignocellulosic materials for the production of a microbial glycolipids, mel, comprising a fermentation preferably using fungi of the genus pseudozyma or other microorganisms such as genetically modified fungi or bacteria.
LaboratÓrio Nacional De Energia E Geologia


03/24/16
20160083706 

Boronate-mediated delivery of molecules into cells


Cargo molecules carrying one or more phenylboronate moieties useful for cellular uptake of the cargo molecules. Phenylboronate can be ligated, crosslinked or otherwise bonded to the cargo molecules.
Wisconsin Alumni Research Foundation


03/24/16
20160083698 

Lone star virus


This disclosure concerns the isolation, identification and sequencing of a unique phlebovirus, the lone star virus. Lone star virus nucleic acid molecules, proteins and antibodies are disclosed.
The United States Of America, As Represented By The Secretary, Department Of Health And Human . . .


03/24/16
20160083689 

Animal protein-free media for cultivation of cells


The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium.
Baxalta Gmbh


03/24/16
20160083688 

Improved methods for making ribosomes


A platform for preparing a sequence defined biopolymer in vitro is disclosed. The platform includes a ribosome-depleted cellular extract ribosomal rnas prepared by in vitro transcription and purified ribosomal proteins depleted of ribosomal rnas.
Northwestern University


03/24/16
20160083482 

Anti-ccl2 and anti-loxl2 combination therapy for treatment of scleroderma


The present invention provides, among other things, bi-specific molecules including, but not limited to, antibodies, fynomers, aptamers, fuproteins, and protein binding domains that bind both ccl2 and loxl2 and uses thereof, in particular, for treatment of scleroderma and related fibrotic and/or inflammatory diseases, disorders and conditions. In some embodiments, the present invention further provides methods and compositions for treatment of scleroderma and related fibrotic and/or inflammatory diseases, disorders and conditions based on the combination of mono-specific anti-ccl2 and anti-loxl2 molecules..
Shire Human Genetic Therapies Inc.


03/24/16
20160083481 

Fusion proteins and immunoconjugates and uses thereof


The present invention relates to isolated vhhs directed against human glycophorin a. The present invention also relates to fusion proteins comprising the vhh according to the invention that is fused to at least one heterologous polypeptide and immunoconjugates comprising the vhh according to the invention that is conjugated to at least one chemical compound and their use in therapeutic or diagnostic methods..
Institut National De La Transfusion Sanguine (ints)


03/24/16
20160083477 

Removal of cancer cells by circulating virus-specific cytotoxic t-cells using cancer cell targeted mhc class 1 compromising multi-function proteins


Herein is reported a multi-function protein, characterized in that it comprises exactly one antigen presenting domain, exactly one antibody fc-region, and at least one antigen binding site, wherein the antigen presenting domain comprises in n- to c-terminal direction either (i) a β2-microglobulin, and (ii) the extracellular domains α1, α2, and α3 of a class i mhc molecule with a relative frequency of less than 1%, or (i) a t-cell response eliciting peptide, (ii) a β2-microglobulin, and (iii) the extracellular domains α1, α2, and α3 of a class i mhc molecule with a relative frequency of 1% or more, wherein the antigen binding site binds to a cancer cell surface antigen.. .
Roche Glycart Ag


03/24/16
20160083454 

Continuous multistep process for purifying antibodies


The invention provides a three-step chromatography process for small and large-scale purification of proteins, specifically monoclonal antibodies, using only four buffer solutions made from a mother solution.. .
Sanofi


03/24/16
20160083441 

Development of protein-based biotherapeutics that penetrate cell-membrane and induce anti-cancer effect - cell-permeable trefoil factor 1 (cp-tff1) in gastrointestinal track (git) cancer, polynucleotides encoding the same, and anti-cancer compositions comprising the same


The present study investigated the use of macromolecule intracellular transduction technology (mitt) to deliver biologically active tff1 protein into gastric cancer cells both in vitro and in vivo. proteins engineered to enter cancer cells are supposed to suppress cell proliferation and survival, consistent with its role as a tumor suppressor.
Cellivery Therapeutics, Inc.


03/24/16
20160083439 

Novel vaccines against apicomplexan pathogens


The technology provided herein generally relates to novel fusion proteins suitable as human and/or animal vaccines against parasites or pathogens of the phylum apicomplexa. In particular, the present disclosure relates to novel fusion proteins as a basis for vaccines against plasmodium parasites, including p.
Fraunhofer-gesellschaft Zur FÖrderung Der Angew Andten Forschung E.v.


03/24/16
20160083425 

Proprotein convertase subtilisin kexin type 9 (pcsk9) allosteric binding ligands to modulate serum low density lipoprotein (ldl) levels


This invention is related to the field of hypercholesterolemia. In particular, the invention provides compositions and methods to modulate circulating levels of low density lipoproteins by altering the conformation of the protein pcsk9 using synthetic ligands and/or synthetic ligand derivative sequences of 3-8 amino acids ranging between 350-2,000 da.
Srx Cardio, Llc


03/24/16
20160083403 

Boron-containing diacylhydrazine compounds


And the pharmaceutically acceptable salts and solvates thereof, wherein a, r4, and r5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems.

03/24/16
20160083384 

Salts and crystalline forms of an apoptosis-inducing agent


Salts and crystalline forms of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-n-({3-nitro-4-[(tetrahydro-2h-pyran-4-ylmethyl)amino]phenyl}-sulfonyl)-2-(1h-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic bcl-2 family proteins, for example cancer.. .
Abbvie Inc.


03/24/16
20160082294 

Pulsating electromagnetic and ultrasound therapy for stimulating targeted heat shock proteins and facilitating protein repair


A system and method are disclosed for stimulating activation of heat shock proteins and facilitating protein repair in cells and tissues in order to take advantage of the remediative and restorative nature of the increased heat shock protein activation or production and the facilitation of protein repair, while not damaging the cells and tissues. This is accomplished by treating a specified target area with an ultrasound or electromagnetic radiation source which is pulsed and applied or focused to one or more small areas in order to achieve the necessary temperature rise or sufficiently stress the cells and tissue to stimulate heat shock protein production or activation and facilitate protein repair, while allowing the temperature to decay sufficiently quickly so as not to damage or destroy the treated tissue..
Ojai Retinal Technology, Llc


03/24/16
20160082279 

System and optogenetic therapy


Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations.
Circuit Therapeutics, Inc.


03/24/16
20160082098 

Outer membrane vesicle (omv) vaccine comprising n. meningitidis serogroup b outer membrane proteins


A composition comprising (a) neisseria meningitidis serogroup b outer membrane vesicles (omvs), and (b) an immunogenic component selected from other neisseria proteins, or immunogenic fragments thereof. Component (b) preferably includes a protein from a different nmb strain from that from which the omv of component (a) is derived.
Glaxosmithkline Biologicals Sa


03/24/16
20160082097 

Neisserial vaccine compositions comprising a combination of antigens


The present invention relates to immunogenic compositions and vaccines for the treatment and prevention of neisserial disease. Immunogenic compositions of the invention contain combinations of antigens selected from at least two different classes of antigens including adhesins, autotransporter proteins, toxins, iron acquisitions proteins and membrane-associated protein (preferably integral outer membrane protein)s.
Glaxosmithkline Biologicals S.a.


03/24/16
20160082096 

Vaccine against streptococcal infections based on recombinant proteins


An antigenic composition comprises several antigenic components derived from antigens of streptococcus equi subsp. Equi or subsp.
Intervacc Ab


03/24/16
20160082086 

Submicron particles for the treatment of radiation damage in patients


A method of treating a patient exposed to radiation before the patient is thrombocytopenic, comprising: intravenous infusion of protein spheres at a concentration of the protein spheres sufficient to reduce the morbidity and mortality of the irradiated patient. The protein spheres are formed from soluble proteins without the addition of surfactants or detergents, and the protein spheres spontaneously and directly bind at least one coagulation factor without the aid of other molecules which specifically bind the at least one coagulation factor..

03/24/16
20160082083 

Method of inhibiting angiogenesis, tumorigenesis and cathepsin activity


Insulin-like growth factor binding proteins (igfbps) and variants thereof, including igfbp-1, igfbp-2, igfbp-3, igfbp-4, igfbp-5, igfbp-8 and the c-terminal fragments thereof, inhibit angiogenesis, tumorigenesis and cathepsin activity, particularly cathepsin b activity.. .
National Research Council Of Canada


03/24/16
20160082046 

In vitro production of red blood cells with sortaggable proteins


Methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express a sortaggable surface protein, which allows for surface modification in the presence of a sortase.
Whitehead Institute For Biomedical Research


03/24/16
20160082044 

Formulations and methods for contemporaneous stabilization of active proteins during spray drying and storage


A method of treatment of plasma with a physiologically compatible spray dry stable acidic substance (sdsas) prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compositions related to plasma dried by the methods of the present invention.. .
Velico Medical, Inc.


03/24/16
20160081984 

Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions


Disclosed herein are compounds and compositions thereof which find use in increasing stability of proteins particularly proteins that tend to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of proteins and thereby decreasing aggregate formation by these proteins.
The Board Of Trustees Of The Leland Stanford Junior University


03/24/16
20160081383 

Dietetic mixtures and dietetic products made therewith for human consumption in particular conditions in which elimination of carbohydrates is necessary


Dietetic mixtures that make it possible to follow a aglucidic and hyperlipidic diet for persons in particular conditions of health which require the elimination of carbohydrates (amides and simple sugars); such dietetic mixtures are made from plant proteins, plant fibers and lipids; the elimination of farinaceous products and their substitution with aglucidic and hyperlipidic products made with the above-mentioned mixtures results in the ketogenic diet, a particular diet that is based on a drastic reduction in carbohydrates.. .
Le Gamberi Foods S.r.l.


03/24/16
20160081348 

Decontamination solution and its use for denaturation, modification, degradation, solubilisation and removal of proteins, nucleic acid molecules and microorganisms


The invention concerns a three component system comprising surface-active substances, vitamins and metal ions for efficient destruction and removal of contaminating proteins, nucleic acids and microorganisms from surfaces like for example laboratory benches, floors, equipment and instruments. These non-corrosive and non-toxic solutions for removal of proteins, nucleic acids and microorganisms are applied by spraying, rubbing or immersion of contaminated surfaces thereby destroying, solubilizing inactivating and removing proteins and nucleic acids.
Multibind Biotec Gmbh


03/17/16
20160077112 

Detection of misfolded proteins


Methods and kits are provided for amplifying and detecting misfolded proteins from samples, for example, from patients having alzheimer's disease, parkinson's disease, and the like. For example, a method for determining a presence of soluble, misfolded protein in a sample may include contacting the sample with a monomeric, folded protein to form an incubation mixture; conducting an incubation cycle two or more times effective to form an amplified portion of misfolded protein; incubating the incubation mixture effective to cause misfolding and/or aggregation of at least a portion of the monomeric, folded protein; physically disrupting the incubation mixture effective to break up at least a portion of any protein aggregate present; and determining the presence of the soluble, misfolded protein in the sample by detecting at least a portion of the soluble, misfolded protein.
Amprion


03/17/16
20160077111 

Detection of misfolded alpha synuclein protein


Methods and kits are provided for amplifying and detecting αs proteins from samples, for example, from patients having parkinson's disease. For example, a method for determining a presence of a soluble, misfolded αs protein may include: contacting the sample with a monomeric, folded αs protein to form an incubation mixture; conducting an incubation cycle two or more times on the incubation mixture effective to form an amplified portion of misfolded αs protein; incubating the incubation mixture effective to cause misfolding and/or aggregation of at least a portion of the monomeric, folded αs protein in the presence of the soluble, misfolded αs protein; physically disrupting the incubation mixture effective to at least partly de-aggregate at least a portion of a misfolded αs aggregate present; and determining the presence of the soluble, misfolded αs protein in the sample by detecting at least a portion of the soluble, misfolded αs protein..
Amprion


03/17/16
20160077110 

Detection of misfolded amyloid beta protein


Methods and kits are provided for amplifying and detecting aβ proteins from samples, for example, from patients having alzheimer's disease. For example, a method for determining a presence of a soluble, misfolded aβ protein may include contacting the sample with a monomeric, folded aβ protein to form an incubation mixture; conducting an incubation cycle two or more times on the incubation mixture effective to form an amplified portion of misfolded aβ protein; incubating the incubation mixture effective to cause misfolding and/or aggregation of at least a portion of the monomeric, folded aβ protein; physically disrupting the incubation mixture effective to at least partly de-aggregate at least a portion of a misfolded aβ aggregate present; and determining the presence of the soluble, misfolded aβ protein in the sample by detecting at least a portion of the amplified portion of misfolded aβ protein..
Amprion


03/17/16
20160077109 

Clinical diagnosis of hepatic fibrosis using a novel panel of human serum protein biomarkers


The inventors have proposed a novel panel of human serum protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis.
The Chancellor, Masters And Scholars Of The University Of Oxford


03/17/16
20160077099 

Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability


A system for making molecules, and proteins in particular, suitable for detection by a surface-selective nonlinear optical technique. A first use of the invention is for determining a protein's structure in real space and real time.
Biodesy, Inc.


03/17/16
20160077095 

Compositions and methods for diagnosing lung cancer


The present invention provides diagnostics for identifying and distinguishing various types of lung cancers using serum and/or bronchioalveolar lavage fluid. Signatures of secretory proteins are used to identify and distinguish lung cancers.
Indiana University Research & Technology Corporation






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