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Proteins patents



      
           
This page is updated frequently with new Proteins-related patent applications. Subscribe to the Proteins RSS feed to automatically get the update: related Proteins RSS feeds. RSS updates for this page: Proteins RSS RSS


Genes and uses for plant improvement

Low temperature hyperthermia system for therapeutic treatment of invasive agents

Date/App# patent app List of recent Proteins-related patents
10/09/14
20140304856
 Plant seeds with altered storage compound levels, related constructs and methods involving genes encoding pae and pae-like polypeptides patent thumbnailPlant seeds with altered storage compound levels, related constructs and methods involving genes encoding pae and pae-like polypeptides
This invention is in the field of plant molecular biology. More specifically, this invention pertains to isolated nucleic acid fragments encoding pae or pae-like proteins in plants and seeds and the use of such fragments to modulate expression of a gene encoding pae or pae-like protein activity in a transformed host cell..
10/09/14
20140304855
 Novel bacterial proteins with pesticidal activity patent thumbnailNovel bacterial proteins with pesticidal activity
Provided are pesticidal, particularly insecticidal, proteins which resemble s-layer proteins, as well as variants or mutants thereof, and dnas encoding them. Further provided are methods and means for using said dna or protein for controlling pests, particularly plant insect pests..
10/09/14
20140304848
 Genes and uses for plant improvement patent thumbnailGenes and uses for plant improvement
This invention provides transgenic plant cells with recombinant dna for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil.
10/09/14
20140303701
 Low temperature hyperthermia system for therapeutic treatment of invasive agents patent thumbnailLow temperature hyperthermia system for therapeutic treatment of invasive agents
The low temperature hyperthermia system illuminates nano-particles, which are implanted in a living organism at the locus of the cancer or into the cancer cells, with a precisely determined energy field. This energy field ensures that the optimal cancer cell and cancer stem cell destruction temperature of 42° c.
10/09/14
20140303455
 Multipurpose cerebrospinal fluid sensor assembly and method of operation of the same patent thumbnailMultipurpose cerebrospinal fluid sensor assembly and method of operation of the same
A cerebrospinal fluid (csf) monitoring device for the detection of obstructions in real time through the collection of pressure data from an on-board pressure sensor. This system is designed to integrate into medical devices equipped with a csf drainage system, such as implantable shunts.
10/09/14
20140303356
 Production of heterodimeric proteins patent thumbnailProduction of heterodimeric proteins
The present invention relates to an in vitro method for production of heterodimeric proteins.. .
10/09/14
20140303353
 Methods for processing coagulation factors patent thumbnailMethods for processing coagulation factors
The present application relates to methods for purifying recombinant coagulation factor proteins, including for example, prothrombin (factor ii). In embodiments, the methods provide purified prothrombin that exhibit increased bioactivity and reduced levels of thrombin, thereby increasing the safety of the prothrombin.
10/09/14
20140303199
 Inhibitors of rgs proteins patent thumbnailInhibitors of rgs proteins
G-protein coupled receptors are a diverse group that are the target of over 50% of marketed drugs. Activation of these receptors results in the exchange of bound gdp for gtp in the gα subunit of the heterotrimeric g-protein.
10/09/14
20140303160
 Targeting gli proteins in human cancer by small molecules patent thumbnailTargeting gli proteins in human cancer by small molecules
The present disclosure provides compositions, pharmaceutical preparations and methods for the diagnosis and treatment of cancers expressing a gli polypeptide. The disclosed compositions and pharmaceutical preparations may comprise one or more pyrazolyl-containing compounds, or an analog or derivative thereof..
10/09/14
20140303077
 Albumin fusion proteins patent thumbnailAlbumin fusion proteins
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells.
10/09/14
20140303035
Propeptide-luciferase fusion proteins and methods of use thereof
The present invention provides nucleic acid constructs that encode fusion peptides comprising a bioluminescent protein and a precursor of a secreted peptide or protein expressed at the cell surface and high throughput screening assays using same.. .
10/09/14
20140303022
Magnetic-nanoparticle conjugates and methods of use
The present invention provides novel compositions of binding moiety-nanoparticle conjugates, aggregates of these conjugates, and novel methods of using these conjugates, and aggregates. The nanoparticles in these conjugates can be magnetic metal oxides, either monodisperse or polydisperse.
10/09/14
20140302999
Method for determination of pharmacological properties of recombinant proteins
The present invention is directed to a method for obtaining an in vitro pharmacological model of a recombinant protein drug in a given host. A plurality of biomolecules are selected which are known or suspected to influence pharmacology of the recombinant protein in the host via a binding interaction with the recombinant protein.
10/09/14
20140302593
Process for purifying vlps
Processes and compositions to produce, package, and purify virus like particles containing heterologous cargo molecules utilizing self assembling proteins and protease treatment coupled with simple precipitation and filtration methods are described.. .
10/09/14
20140302592
Protein purification by anion exchange chromatography
The present invention relates to a two-step method for the purification of divalent cation binding proteins with high yield and high purity on anion exchange resin materials, to divalent cation binding proteins obtainable by said method, and to a kit comprising means for carrying out said method.. .
10/09/14
20140302591
Protein purification by anion exchange chromatography
The present invention relates to a two-step method for the purification of divalent cation binding proteins with high yield and high purity on anion exchange resin materials, to divalent cation binding proteins obtainable by said method, and to a kit comprising means for carrying out said method.. .
10/09/14
20140302583
Genetically inducible hydrogen peroxide resistance and production
Dna constructs as well as methods for the production of unicellular organisms capable of producing hydrogen peroxide resistance proteins are disclosed. Dna constructs as well as methods for integration of the dna constructs into the genomes of unicellular organisms for the expression of hydrogen peroxide production proteins are also disclosed.
10/09/14
20140302561
3s-rhamnose-glucuronyl hydrolase, method of production and uses
The present invention relates in particular to proteins, coding nucleic acid sequences for same, vectors comprising said coding sequences, a method for producing said proteins, and an oligosaccharide hydrolysis method using same. In particular, the invention relates to the protein of sequence seq id no.
10/09/14
20140302557
Engineered lower eukaryotic host strains for recombinant protein expression
The present invention relates to novel engineered lower eukaryotic host cells for expressing heterologous proteins and to methods of generating such strains.. .
10/09/14
20140302556
Controlling o-glycosylation in lower eukaryotes
Lower eukaryote host cells in which expression of the endogenous protein mannosyltransferase 2 (pmt2) gene has been disrupted by introducing a nucleic acid molecule encoding a pmt2p protein having a mutation in a conserved region of the protein. The mutation confers to the host cell resistance to pmt inhibitors, which are used to reduce the amount of o-glycosylation of recombinant proteins produced by the host cells but which also have the effect of reducing the robustness of the host cells during fermentation.
10/09/14
20140302554
Non-ionic acid-labile surfactants and methods of use
Wherein r1 is independently selected from c2-c10 alkyl or substituted alkyl, r2 is independently selected from the group consisting of —h and c1-c6 alkyl or substituted alkyl, x is selected from the group consisting of —nh— and —o—, y is a carbohydrate, and m is an integer from 1 to 8. The compound may comprise a non-ionic acid labile surfactant.
10/09/14
20140302553
Biosynthetically generated pyrroline-carboxy-lysine and site specific protein modifications via chemical derivatization of pyrroline-carboxy-lysine and pyrrolysine residues
Disclosed herein is pyrroline-carboxy-lysine (pcl), a pyrrolysine analogue, which is a natural, biosynthetically generated amino acid, and methods for biosynthetically generating pcl. Also disclosed herein are proteins, polypeptides and peptides that have pcl incorporated therein and methods for incorporating pcl into such proteins, polypeptides and peptides.
10/09/14
20140302545
Enzyme treatment apparatus for proteins using a hollow fiber membrane, and on-line proteomics method using same
Provided are an enzyme treatment apparatus for proteins using a hollow fiber membrane and an on-line proteomics method using same. The enzyme treatment apparatus for proteins according to the present invention can increase a recovery rate of peptides, which are recovered through an enzyme treatment process, by basically solving the problem of low reproducibility of an enzyme activity which may occur during a conventional enzyme treatment process, and can also reduce a time for purification and provide higher yield by performing separation and purification through a single step.
10/09/14
20140302530
Cmv glycoproteins and recombinant vectors
This invention also relates to recombinant vectors expressing one or more of the human cmv (hcmv) glycoproteins us2, us3, us6 and us11 or corresponding functional rhesus cmv (rhcmv) homologues rh182, rh184, rh185 or rh189, methods of making them, uses for them, expression products from them, and uses for the expression products. This invention also relates to recombinant cytomegalovirus vectors vectors lacking one or more of the glycoproteins, methods of making them, uses for them, expression products from them, and uses for the expression products..
10/09/14
20140302523
Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same
The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of a compound to the transmembrane or intracellular protein induces proteasomal degradation of the transmembrane or intracellular protein. The present invention further includes a method of inducing proteasomal degradation of a transmembrane or intracellular protein.
10/09/14
20140302518
Detection of infectious prion protein by seeded conversion of recombinant prion protein
The present disclosure relates to methods and compositions for the detection of infectious proteins or prions in samples, including the diagnosis of prion related diseases. One embodiment is an ultrasensitive method for detecting prp-res (prpsc) that allows the use of recombinant prp-sen (rprp-sen) as a substrate for seeded polymerization.
10/09/14
20140302124
Cytotoxic t lymphocyte inducing immunogens for prevention treatment and diagnosis of influenza virus infection
Influenza virus infection and the resulting complications are a significant global public health problem and understanding the overall immune response to infection will contribute to appropriate management of the disease and its potentially severe complications. Improving humoral immunity to influenza is the target of current conventional influenza vaccines, however, these are generally not cross-protective.
10/09/14
20140302089
Pharmaceutical compositions for preventing and/or treating an hiv disease in humans
The present invention relates to pharmaceutical compositions comprising a mixture of a specific hiv antigen and a non-pathogenic living bacterium. Said specific hiv antigen comprises one or more epitopes from gag and/or pol proteins and is preferably under a particulate form.
10/09/14
20140302079
Novel influenza hemagglutinin protein-based vaccines
Novel vaccines are provided that elicit broadly neutralizing anti-influenza antibodies. Some vaccines comprise nanoparticles that display hemagglutinin trimers from influenza virus on their surface.
10/09/14
20140302078
Haemophilus influenzae type b
Polypeptides comprising various amino acid sequences derived from haemophilus influenzae type b, including a number of lipoproteins. These can be used in the development of vaccines for preventing and/or treating bacterial meningitis.
10/09/14
20140302075
Aspartyl-trna synthetases
The present invention provides aspartyl-trna synthetase derived proteins (drs polypeptides) with altered cysteine content, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The drs polypeptides of the invention have immunomodulatory properties, and exhibit improved activity and stability..
10/09/14
20140302072
Non-natural mic proteins
This invention describes soluble, monovalent, non-natural protein molecules that can activate nk cells and certain t-cells to attack specific cellular target cells by attaching the nkg2d-binding portions of monovalent mica or micb protein, i.e. Their α1-α2 platform domain, to the intended target cell specifically.
10/09/14
20140302070
Novel pd1 isoforms, and uses thereof for potentiating immune responses
In one embodiment, the present invention provides a new isoform of human pd1 (Δ42pd1) that contains a 42-nucleotide in-frame deletion located at exon 2 domain. Δ42pd1 does not engage pd-l1/pd-l2, and can induce the production of pro-inflammatory cytokines in one embodiment, Δ42pd1 can be used as an intramolecular adjuvant to develop a fusion dna vaccine for enhancing antigen-specific cd8+ t cell immunity and for prevention of pathogenic infection and/or cancer.
10/09/14
20140302048
Plasma kallikrein binding proteins
Plasma kallikrein binding proteins and methods of using such proteins are described.. .
10/09/14
20140302046
Immunological targeting of pathological tau proteins
The present invention relates to methods and compositions for treating, preventing, and diagnosing alzheimer's disease or other tauopathies in a subject by administering an immunogenic tau peptide or an antibody recognizing the immunogenic tau epitope under conditions effective to treat, prevent, or diagnose alzheimer's disease or other tauopathies. Also disclosed are methods of promoting clearance of aggregates from the brain of the subject and of slowing progression of tau-pathology related behavioral phenotype in a subject..
10/09/14
20140302038
Multispecific and multivalent binding proteins and uses thereof
The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making and using such proteins..
10/09/14
20140302036
Proteins specific for baff and b7rp1
Described herein are bispecific proteins specific for baff and b7rp1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.. .
10/09/14
20140302026
Means and methods for treating angiogenesis-related diseases
The present invention is concerned with a protein oligomer comprising at least two nc-1 monomers of human collagen 18 or fragments of an nc-1 monomer of human collagen 18 for use in the treatment or prevention of an angiogenesis-related disease. The invention further pertains to a fusion protein comprising a nc-1 monomer of human collagen 18 and a fc domain of an immunoglobulin.
10/09/14
20140302025
Vegf-binding protein for blockade of angiogenesis
Provided are chimeric vegf-binding proteins and nucleic acids (e.g., a vector) encoding chimeric vegf-binding proteins, methods and host cells for producing these proteins and nucleic acids, and pharmaceutical compositions containing these proteins and nucleic acids. Also provided are methods of treating an angiogenic disease or disorder that include administering at least one of the chimeric vegf-binding proteins or at least one of the nucleic acids (e.g., a vector) encoding a chimeric vegf-bind ing protein..
10/09/14
20140302024
Serum amyloid p-antibody fusion proteins
Functionalized pentraxin-2 (ptx-2) protomers and functionalized ptx-2 pentamers, methods for preparing functionalized ptx-2 protomers and functionalized ptx-2 pentamers, pharmaceutical compositions including functionalized ptx-2 pentamers, and methods for using the same are described herein.. .
10/09/14
20140302016
Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof
This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a cd154 (cd40l) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized fab fragment comprising a variable heavy chain sequence according to seq id no: 1 and comprising a variable light chain sequence according to seq id no: 2 specifically binds.
10/09/14
20140302004
Triple acting antimicrobials that are refractory to resistance development
Multi-drug resistant superbugs are a persistent problem in modern health care. This invention provides an antimicrobial endolysin-lysostaphin triple fusion protein, comprising (1) an endolysin chap endopeptidase domain, (2) an endolysin amidase domain, and (3) a lysostaphin glycyl-glycine endopeptidase domain.
10/09/14
20140301974
Extended recombinant polypeptides and compositions comprising same
The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (xten), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.. .
10/09/14
20140299532
Filtration with internal fouling control
Filtration processes and systems are provided for the separation of a filterable fluid stream by a filtration membrane module with uniform transmembrane pressure and flux along the membrane and internal control of membrane fouling via intermittent periodic reduction of the pressure differential between the permeate and retentate sides of the membrane and/or backwashing cycles during separation, recovery, and/or purification of proteins, peptides, nucleic acids, biologically produced polymers and other compounds or materials from aqueous fluids.. .
10/09/14
20140299468
High-performance analytical instrument and method
Apparatus and methods are provided for improving sensitivity, throughput, and efficiency of multi-analyte analytical testing. Specifically, an improved electrochemiluminescence (ecl) analytical apparatus is provided for analytical chemistry, diagnostics, and environmental applications.
10/02/14
20140298538
Axmi205 variant proteins and methods of use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided.
10/02/14
20140298508
Alpha-mannosidases from plants and methods for using the same
The present invention is directed to alpha-mannosidase sequences from plants and the use thereof, especially genomic nucleotide sequences containing the regulatory elements controlling their expression, intron and exon sequences and polynucleotide sequences coding for alpha-mannosidase enzymes. Such plants with modified alpha-mannosidase activity can be used for the production of glycoproteins having an altered saccharide composition of great benefit.
10/02/14
20140298505
Protein having nuclease activity, fusion proteins and uses thereof
The present invention relates to a nucleic acid molecule encoding (i) a polypeptide having the activity of an endonuclease, which is (a) a nucleic acid molecule encoding a polypeptide comprising or consisting of the amino acid sequence of seq id no: 1; (b) a nucleic acid molecule comprising or consisting of the nucleotide sequence of seq id no: 2; (c) a nucleic acid molecule encoding an endonuclease, the amino acid sequence of which is at least 70% identical to the amino acid sequence of seq id no: 1; (d) a nucleic acid molecule comprising or consisting of a nucleotide sequence which is at least 50% identical to the nucleotide sequence of seq id no: 2; (e) a nucleic acid molecule which is degenerate with respect to the nucleic acid molecule of (d); or (f) a nucleic acid molecule corresponding to the nucleic acid molecule of any one of (a) to (e) wherein t is replaced by u; (ii) a fragment of the polypeptide of (i) having the activity of an endonuclease. Also, the present invention relates to a vector comprising the nucleic acid molecule and a protein encoded by said nucleic acid molecule.
10/02/14
20140298503
Glycosylation in avians
Transgenic avians which produce proteins in their oviduct tissue having modified oligosaccharide structures and methods of making such avians are disclosed herein. The invention also includes the modified proteins produced in the transgenic birds..
10/02/14
20140296492
Hla-restricted, peptide-specific antigen binding proteins
Antigen binding proteins with tcr-like paratopes, that is, with an antigen binding region specific for an hla-a2 restricted peptide are disclosed. The antigen binding proteins encompass antibodies in a variety of forms, including full-length antibodies, substantially intact antibodies, fab fragments, f(ab′)2 fragments, and single chain fv fragments.
10/02/14
20140296491
Generating metal ion binding proteins
The present invention provides for a method for generating a metal ion binding protein, the method comprising a) integrating the amino acid sequence ddd into cdr1 of a light chain variable region of an antibody or fragment thereof; and b) combining the sequence of step a) with a heavy chain variable region of an antibody or fragment thereof; and c) isolating the protein. Also provided is the use of metal ion binding proteins generated by the method of the present invention for isolation and purification of proteins and for the reversible labeling of a target molecule.
10/02/14
20140296486
Novel aav's and uses thereof
The invention in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the invention relates to gene transfer methods using the recombinant adeno-associate viruses.
10/02/14
20140296464
Chromatography medium
The present invention provides a chromatography medium comprising one or more electrospun polymer nanofibres which form a stationary phase comprising a plurality of pores through which a mobile phase can permeate and use of the same in chromatography, such as the isolation of recombinant proteins, monoclonal antibodies, viral vaccines and plasmid dna. The invention further provides for the use of the chromatographic medium in a simulated moving bed system..
10/02/14
20140296434
Chromatography matrices including novel staphylococcus aureus protein a based ligands
The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, staphylococcus aureus protein a (spa), as well as methods of using the same.. .
10/02/14
20140296353
Prion free nanoparticle compositions and methods of making thereof
The present invention provides prion-free compositions comprising nanoparticles comprising albumin and substantially water insoluble drugs. Also provided are methods of making prion-free compositions and methods of removing prion proteins from the nanoparticle compositions.
10/02/14
20140296321
Methods and compositions for manipulating translation of protein isoforms from alternative initiation of start sites
Provided herein are antisense oligonucleotides, compositions comprising antisense oligonucleotides, and methods for the use of antisense oligonucleotides in manipulating translation. Expression of isoforms of proteins expressed from different start codons of the same transcript are inhibited by antisense oligonucleotides, which may also enhance expression of non-target isoforms..
10/02/14
20140296248
Methods and compositions for predicting resistance to anticancer treatment
The instant application provides methods and related compositions pertaining to the identification of resistance to anticancer treatment in a patient. In a particular embodiment, the invention provides biomarkers for the identification of resistance to anticancer treatment in a lung cancer patient, wherein a reduced expression of a mediator and/or sw1/snf complex gene in the lung cancer cells of the patient indicates that the lung cancer cells in the patient may be resistant to treatment with a receptor tyrosine kinase inhibitor, such as gefitinib and/or erlotinib.
10/02/14
20140296243
Bromodomain inhibitors and uses thereof
The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders..
10/02/14
20140296181
Methods of modulating oncogenic fusion proteins
Described herein, at least in part, are methods of modulating oncogenic fusion proteins.. .
10/02/14
20140296167
Glycosylation site-specific antibodies and anti-cancer compounds
A method of characterizing the protein o-glcnacylation site-specificity of an antibody. A method of detecting or quantitating the expression of site-specific o-glcnacylated proteins expressed in cells and biological samples.
10/02/14
20140296164
Compositions and methods of use for cell targeted inhibitors of the cystic fibrosis transmembrane regulator associated ligand
The present invention describes peptide drugs that inhibit the interaction between cal and cftr, and other proteins in cystic fibrosis and other diseases. These invented drugs have been chemically optimized to impart solubility, stability, cell permeability, mucus penetration, intracellular targeting and sequestration, increased potency and non-immunogenicity, while conserving and imparting efficacy.
10/02/14
20140296162
Whey protein composition with a reduced astringency
The invention relates to a sterilized liquid or semi-solid acid enteral composition comprising per 100 ml 9 to 20 g of non-hydrolysed globular proteins, fat and at least 100 mg of divalent metal cations and having a ph ranging between 3 and 5. The invention further relates to a method for preparing a composition according to the invention, comprising a step wherein at least the non-hydrolysed globular proteins are subjected to a direct steam injection (dsi) at specific holding values, such as a holding temperature of 100 to 140° c.
10/02/14
20140296156
Peptide based inhibition of capcna interaction in cancer
Peptides derived from cancer specific isoform of proliferating cell nuclear antigen (capcna, also known as cspcna) or from nmpcna-interacting proteins interfere with intracellular protein-protein interaction, thereby causing a reduction in the proliferative potential of cancer. These peptides serve as therapeutic compositions to reduce the proliferation of cancer cells and also augment existing chemotherapeutic methods..
10/02/14
20140296108
Biomarkers and methods for predicting preeclampsia
The disclosure provides biomarker panels, methods and kits for determining the probability for preeclampsia in a pregnant female. The present disclosure is based, in part, on the discovery that certain proteins and peptides in biological samples obtained from a pregnant female are differentially expressed in pregnant females that have an increased risk of developing in the future or presently suffering from preeclampsia relative to matched controls.
10/02/14
20140296102
Nucleic acid ligand diagnostic biochip
A nucleic acid ligand “biochip” is disclosed, consisting of a solid support to which one or more specific nucleic acid ligands is attached in a spatially defined manner. Each nucleic acid ligand binds specifically and avidly to a particular target molecule contained within a test mixture, such as a bodily fluid.
10/02/14
20140296101
Secreted proteins and uses thereof
The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies.
10/02/14
20140296093
Use of multiple recombination sites with unique specificity in combinational cloning
The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites with unique specificity.
10/02/14
20140296082
Dna polymerase variants with reduced exonuclease activity and uses thereof
Compositions and methods are described to modify family b dna polymerases that contain residual exonuclease activity that interferes with sequencing techniques and with detection of single nucleotide polymorphisms. The compositions are mutant proteins with reduced exonuclease activity compared with presently available “exo−” polymerases, and a sensitive screening assay that enables an assessment of exonuclease activity of any synthetic dna polymerase..


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