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Proteins patents



      
           
This page is updated frequently with new Proteins-related patent applications. Subscribe to the Proteins RSS feed to automatically get the update: related Proteins RSS feeds. RSS updates for this page: Proteins RSS RSS


Date/App# patent app List of recent Proteins-related patents
05/28/15
20150150156
 Methods and compositions for reducing gene expression in plants patent thumbnailnew patent Methods and compositions for reducing gene expression in plants
The present disclosure relates to recombinant methyltransferases that epigenetically silence gene expression and to methods of using such proteins for reducing the expression of genes in plants.. .
The Regents Of The University Of California
05/28/15
20150150152
 Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system patent thumbnailnew patent Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression.
Intrexon Corporation
05/28/15
20150148407
 Optogenetic inhibition of overactive neuronal activity patent thumbnailnew patent Optogenetic inhibition of overactive neuronal activity
This disclosure relates to recombinant proteins, vectors, and methods of treating neurological conditions by exposing neurons to an opsin and luciferase in the presence of a luciferin. In certain embodiments, the disclosure relates to treating or preventing epilepsy or seizures comprising administering an effective amount of a vector that encodes an opsin and luciferase in combination with a luciferin to a subject in need thereof..
Emory University
05/28/15
20150148375
 Bicyclic heterocycles as bet protein inhibitors patent thumbnailnew patent Bicyclic heterocycles as bet protein inhibitors
The present invention relates to bicyclic heterocycles which are inhibitors of bet proteins such as brd2, brd3, brd4, and brd-t and are useful in the treatment of diseases such as cancer.. .
Incyte Corporation
05/28/15
20150148372
 Bicyclic heterocycles as bet protein inhibitors patent thumbnailnew patent Bicyclic heterocycles as bet protein inhibitors
The present invention relates to bicyclic heterocycles which are inhibitors of bet proteins such as brd2, brd3, brd4, and brd-t and are useful in the treatment of diseases such as cancer.. .
Incyte Corporation
05/28/15
20150148342
 Bicyclic heterocycles as bet protein inhibitors patent thumbnailnew patent Bicyclic heterocycles as bet protein inhibitors
The present invention relates to bicyclic heterocycles which are inhibitors of bet proteins such as brd2, brd3, brd4, and brd-t and are useful in the treatment of diseases such as cancer.. .
Incyte Corporation
05/28/15
20150148337
 Benzo [c] isoxazoloazepine bromodomain inhibitors and uses thereof patent thumbnailnew patent Benzo [c] isoxazoloazepine bromodomain inhibitors and uses thereof
The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders..
Constellation Pharmaceuticals, Inc.
05/28/15
20150148333
 Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof patent thumbnailnew patent Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof
The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders..
Contellation Pharmaceuticals, Inc.
05/28/15
20150148331
 Melt-extruded solid dispersions containing an apoptosis-inducing agent patent thumbnailnew patent Melt-extruded solid dispersions containing an apoptosis-inducing agent
A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a bcl-2 family protein inhibitory compound of formula i as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises subjecting to elevated temperature the compound of formula i, the water-soluble polymeric carrier and the surfactant, to provide an extrudable semi-solid mixture; extruding the semi-solid mixture; and cooling the resulting extrudate to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein.
Abbvie Deutschland Gmbh & Co Kg
05/28/15
20150148293
 Fibroblast growth factor mutants having improved functional half-life and methods of their use patent thumbnailnew patent Fibroblast growth factor mutants having improved functional half-life and methods of their use
Mutant fibroblast growth factor (fgf) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the fgf-1 subfamily of genes from a mammalian species, such as human, and with a specific amino acid substitution of an alanine at a position corresponding to amino acid position 66 of human fgf-1 with a cysteine and/or a specific amino acid substitution of a phenylalanine at a position corresponding to amino acid position 132 of human fgf-1 with a tryptophan (based on the 140 amino acid numbering scheme of human fgf-1) are provided. Other amino acid mutations or substitutions may be combined.
Florida State University Research Foundation
05/28/15
20150148288
new patent

Toxic peptide production, peptide expression in plants and combinations of cysteine rich peptides


New insecticidal proteins, nucleotides, peptides, their expression in plants, methods of producing the peptides, new processes, production techniques, new peptides, new formulations, and new organisms, a process which increases the insecticidal peptide production yield from yeast expression systems. The present invention is also related and discloses selected endotoxins we call cysteine rich insecticidal peptides (crips) which are peptides derived from bacillus thuringiensis (bt) and their genes and endotoxins in combination with toxic peptides known as inhibitor cystine knot (ick) genes and peptides as well as with other types of insecticidal peptides such as trypsin modulating oostatic factor (tmof) peptide sequences used in various formulations and combinations; of both genes and peptides, useful for the control of insects..
Vestaron Corporation
05/28/15
20150148260
new patent

Analyte mass spectrometry quantitation using a universal reporter


Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.. .
05/28/15
20150148259
new patent

Novel phenyl glyoxal probes


Novel phenyl-glyoxal based anti-citrulline probes and methods of synthesis are provided. Methods of use, such as, the development of methods for monitoring substrate citrullination over time; for identifying citrullinated proteins from cells are described..
The Scripps Research Institute
05/28/15
20150147822
new patent

Assays


The invention provides an assay for assessing the conformational stability of a membrane protein, comprising: (a) providing a sample comprising a first population and a second population of a membrane protein; wherein the membrane protein in the first population is labelled with a donor label and the membrane protein in the second population is labelled with an acceptor label, or the membrane protein in the first population is labelled with an acceptor label and the membrane protein in the second population is labelled with a donor label, (b) exposing the first and second populations of the membrane protein to a stability modulating agent and/or condition, (c) and assessing aggregation between membrane proteins of the first and second populations by activating the donor label to permit a distance-dependent interaction with the acceptor label, which interaction produces a detectable signal.. .
Heptares Therapeutics Limited
05/28/15
20150147810
new patent

Ultrathin parylene-c semipermeable membranes for biomedical applications


Thin parylene c membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides.
University Of Southern California
05/28/15
20150147784
new patent

Reagents and methods for detecting influenza virus proteins


Two universally conserved sequences from influenza type a neuraminidases were identified by large scale sequence analysis then chemically modified and conjugated to carrier proteins to generate mono-specific and monoclonal antibodies. The two antibodies, one targeting the n-terminus of the type a neuraminidase and the other sequence close to enzymatic active site, were capable of binding to all 9 subtypes of neuraminidase while demonstrating remarkable specificity against the viral neuraminidase sequences since no cross-reactivity against allantoic proteins was observed.
Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health
05/28/15
20150147782
new patent

Light-inducible promoter and gene expression system containing same


The present invention relates to a light-inducible promoter and a gene expression system containing the same, and provides: a light-inducible promoter comprising a nucleotide sequence represented by seq id no: 12; and a method for producing heterologous proteins using the same. Since the light-inducible promoter of the present invention induces the expression of a gene by the irradiation of light and regulates an expression amount of the gene according to an intensity of light, it is possible to conveniently regulate the expression of the gene without straining the growth or metabolic process of an organism.
Industry-university Coopertion Foundation Hanyang University
05/28/15
20150147761
new patent

Specific biomarkers for hepatocellular carcinoma (hcc)


The invention relates to specific marker proteins (biomarkers) for hepatocellular carcinoma (hcc). The invention relates to a method for the diagnostic study of biological samples of a human for hepatocellular carcinoma, the sample being studied for one or more proteins as a marker for hepatocellular carcinoma, a concentration of the proteins which is elevated or decreased in relation to the healthy state indicating the presence of hepatocellular carcinoma, a diagnostic test kit and a method of screening compounds effective in hcc..
05/28/15
20150147485
new patent

Device for the microstructured grafting of proteins onto a substrate


The invention relates to a device for the microstructured grafting of a plurality of proteins onto a substrate, which includes a substrate (7), a film, a matrix (10), a light source (9), an optical system (11), a first container (1) for receiving a first aqueous solution, a second container (2) for receiving a second aqueous solution, and a microfluidic circuit, wherein the film is arranged on the substrate, the source is suitable for illuminating the matrix with the light, the matrix is suitable for propagating the light in a first structured pattern, the matrix includes an optical means for replacing the first structured pattern with a second structured pattern, the optical system is suitable for forming, on the film, a first microstructured image of the first pattern, the circuit is suitable for containing the first aqueous solution, the circuit includes an opening for placing the first solution in contact with the film at the opening, the circuit includes a microfluidic means for replacing the first solution with the second solution, and the film contains polyethylene glycol.. .
Université De Bordeaux Segalen
05/28/15
20150147417
new patent

Method and pharmaceutical composition for liver fibrosis prevention and/or treatment


The present invention is related to a method for liver fibrosis prevention and/or treatment and a pharmaceutical composition thereof. The method and the pharmaceutical composition are made by taking the advantage of blumea lacera ‘efficacy in accumulating lipid in hepatic stellate cells, down-regulating the proliferation of hepatic stellate cells, inhibiting the mobility of hepatic stellate cells, preventing the activation of hepatic stellate cells, and decreasing the synthesis of ecm proteins.
National Dong Hua University
05/28/15
20150147343
new patent

Method of providing disease-specific binding molecules and targets


Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as alzheimer's disease are described..
University Of Zurich
05/28/15
20150147334
new patent

Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins


The present invention is directed to pharmaceutical agents and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated antibodies that recognize a common conformational epitope of amyloidogenic proteins or peptides that are useful for the diagnosis, treatment, and prevention of amyloid disease..
New York University
05/28/15
20150147332
new patent

Bordetella outer-membrane protein antigens and methods of making and using the same


An isolated protein or peptide selected from the group consisting of bordetella colonization factor a (bcfa) protein and antigenic fragments thereof is described, along with an isolated nucleic acid encoding the same, antibodies that bind to the same, methods of producing an immune response in a mammalian subject in need thereof by administering the proteins, peptides or antibodies, and pharmaceutical compositions comprising the same.. .
Wake Forest University Health Sciences
05/28/15
20150147327
new patent

Dual variable domain immunoglobulin and uses thereof


The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.. .
Abbvie Inc.
05/28/15
20150147325
new patent

Serpin fusion polypeptides and methods of use thereof


This invention relates to molecules, particularly polypeptides, more particularly fusion proteins that include a serpin polypeptide or an amino acid sequence that is derived from a serpin and second polypeptide comprising of at least one the following: an fc polypeptide or an amino acid sequence that is derived from an fc polypeptide; a cytokine targeting polypeptide or a sequence derived from a cytokine targeting polypeptide; a wap domain containing polypeptide or a sequence derived from a wap containing polypeptide; and an albumin polypeptide or an amino acid sequence that is derived from a serum albumin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules..
Inhibrx Llc
05/28/15
20150147324
new patent

Wap domain fusion polypeptides and methods of use thereof


This invention relates to fusion proteins that include a whey acidic protein (wap) domain-containing polypeptide and a second polypeptide. Additionally, the invention relates to fusion proteins that include a wap domain-containing polypeptide a second polypeptide, and a third polypeptide.
Inhibrx Llc
05/28/15
20150147323
new patent

Modulating the alternative complement pathway


Provided herein are compositions, including pharmaceutical compositions, and methods for modulating, i.e., stimulating or inhibiting, activity of the alternative complement pathway, and methods of identifying factor h-binding proteins.. .
The Regents Of The University Of Colorado, A Body Corporate
05/28/15
20150147318
new patent

Caninized anti-ngf antibodies and methods thereof


The invention provides novel caninized anti-ngf antibodies (such as caninized anti-ngf antagonist antibodies and antigen binding proteins), and polynucleotides encoding the same. The invention further provides use of said antibodies or antigen binding proteins and/or nucleotides in the treatment and/or prevention of ngf related disorders, particularly pain..
Zoetis Llc
05/28/15
20150147307
new patent

N-terminal derivatisation of proteins with polysaccharides


The present invention relates to methods for producing n-terminal derivatives of proteins in which a polysaccharide, preferably having at least terminal sialic units, and preferably consisting essentially only of sialic acid units, is reacted at the n-terminus of a protein or peptide under controlled conditions to produce an n-terminal derivative. The controlled conditions include use of acidic ph for the derivatisation step and a higher ph for purification.
Lipoxen Technologies Limited
05/28/15
20150146205
new patent

Measurement of serum lipoproteins


Although a more accurate estimate of a person's risk of cardiovascular disease can be made on the basis of the number of lipoprotein particles per unit volume in the person's blood, current methods all rely on measuring the mass of lipoprotein cholesterol per unit volume. It has been discovered that a rapid and accurate lipoprotein particle count can be obtained by photometry.
Atherotech,inc.
05/21/15
20150143584

Nucleic acid molecules encoding polypeptides involved in regulation of sugar and lipid metabolism and methods of use viii


This invention relates generally to nucleic acid sequences encoding proteins that are related to the presence of seed storage compounds in plants. More specifically, the present invention relates to arabidopsis thaliana, brassica napus, glycine max and oryza sativa nucleic acid sequences encoding sugar and lipid metabolism regulator proteins and the use of these sequences in transgenic plants.
Basf Plant Science Gmbh
05/21/15
20150143574

New plant resistance gene


The invention relates to a new gene that is able to provide plants with resistance against pathogens, more preferably verticillium, ralstonia or fusarium. Said gene is typical for brassicaceae and encodes for a proteins having a sequence as depicted in fig.
Stichting Voor De Technische Wetenschappen
05/21/15
20150143573

Brassica rod1 gene sequences and uses thereof


The present invention relates to brassica juncea rod1 nucleic acid sequences and proteins and the use thereof to create plants with increased levels of c18:1 and reduced levels of saturated fatty acids in the seeds.. .
Bayer Cropscience Nv
05/21/15
20150143563

Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences


The invention is directed to reliable and efficient detection of mrnas as well as other rnas in living cells and its use to identify and, if desired, separate cells based on their desired characteristics. Such methods greatly simplify and reduce the time necessary to carry out previously-known procedures, and offers new approaches as well, such as selecting cells that generate a particular protein or antisense oligonucleotide, generating cell lines that express multiple proteins, generating cell lines with knock-out of one or more protein, and others..
Chromocell Corporation
05/21/15
20150141626

Reducing the immunogenicity of fusion proteins


Disclosed are compositions and methods for producing fusion proteins with reduced immunogenicity. Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional epitope to bind to mhc class ii, thereby reducing its interaction with a t-cell receptor.
Merck Patent Gmbh
05/21/15
20150141623

Protein purification methods to reduce acidic species


The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of charge variants, aggregates, and fragments of a protein of interest, as well as host cell proteins, present in purified preparations by applying particular chromatography conditions during such protein purification.. .
Abbvie, Inc.
05/21/15
20150141618

Solution-dyed protein fiber and producing same


A solution-dyed protein fiber of the present invention includes 0-100 mass % of silk fibroin and 100-0 mass % of a polypeptide derived from spider silk proteins when the protein fiber is assumed to be 100 mass %, wherein the solution-dyed protein fiber contains a solution-dyeing colorant. The fiber is obtained by: dissolving or dispersing a solution-dyeing colorant in a solvent used for a spinning solution or in dimethyl sulfoxide, thereby preparing a coloring liquid; adding a solvent to the coloring liquid in an amount necessary for a spinning solution; adding and dissolving protein powder into the solvent, thereby preparing a spinning solution; and subjecting the spinning solution to wet spinning or dry-wet spinning.
Spiber Inc.
05/21/15
20150141488

Small molecule inhibitors of rna binding motif (rbm) proteins for the treatment of acute cellular injury


The remaining r1-r8 are each independently selected from hydrogen, halo, hydroxyl, nitro, nitroso, amino, substituted amino, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoy, alkenyloxy, substituted alkenyloxy, alkynyloxy, substituted alkynyloxy, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, cycloalkynyl, substituted cycloalkynyl, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyl, substituted heterocyclyl, heterocyclyloxy, substituted heterocyclyloxy, heterocyclylthio, substituted heterocyclylthio, cyano, acyl, acylamino, acyloxy, aminocarbonyl, aminocarbonylamino, aminothiocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, aryl, substituted aryl, aryloxy, substituted aryloxy, arylthio, substituted arylthio, alkylthio, substituted alkylthio, cycloalkylthio, substituted cycloalkylthio, cycloalkenylthio, substituted cycloalkenylthio, thiol, heteroaryl, substituted heteroaryl, heteroaryloxy, substituted heteroaryloxy, heteroarylthio, substituted heteroarylthio, sulfonyl, or sulfonyloxy.. .
05/21/15
20150141347

Murine anti-ny-eso-1 t cell receptors


The invention provides an isolated or purified t cell receptor (tcr) having antigenic specificity for ny-eso-1. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions.
The United States Of America, As Represented By The Secretary, Department Of Health & Human Serv.
05/21/15
20150141345

Novel compounds and methods for inhibiting cell death


This invention provides novel compounds and methods for promoting cell survival and/or plasticity, especially in neuronal cells, by targeting the microtubule end binding (eb) proteins and other associated proteins (e.g., drebrin). Methods for identifying potential modulators of cell death/plasticity are also described..
Ramot At Tel-aviv University
05/21/15
20150141335

Therapeutic uses of fibroblast growth factor 21 proteins


The present invention relates to therapeutic uses of human fibroblast growth factor 21 (fgf21) proteins.. .
Eli Lilly And Company
05/21/15
20150141311

Cleaning compositions and methods for burnt-on food and oil residues


Disclosed herein are compositions comprising a solubilizing agent for the removal of burnt-on, cooked-on, baked-on, dried-on and charred organic food and oil residues from surfaces comprising alcohol, a coupling agent, water, an anti-deposition agent, a ph buffer and a surfactant system that preferably includes a fermentation supernatant, where the supernatant contains essentially stress proteins. Further enclosed are methods of cleaning for ovens, industrial cooking equipment and the like..
Advanced Biocatalytics Corporation
05/21/15
20150141278

Multiplexed assay lung cancer classification


A method for providing a composite image of a single biological sample from a patient suspected of having lung cancer, comprising the steps of generating a first image of the biological sample, generating a second image of the biological sample, and generating a composite image that provides the relative location of both the targeted proteins. Also provided is a method of analyzing a biological sample, comprising providing a composite image of the biological sample according to the method for providing a composite image, and analyzing the expression of the protein of interest from the composite image.
Clarient Diagnostic Services, Inc.
05/21/15
20150140646

Systems and methods for detection and quantification of analytes


Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component.
Cue Inc.
05/21/15
20150140644

Treatment of leaf tissue for the recovery of interstitial recombinant proteins by the application of cell wall degrading enzymes


The present disclosure relates to methods of increasing the purity of an apoplast-targeted recombinant protein recovered from a plant tissue, and increasing the yield of recovery of an apoplast-targeted recombinant protein from a plant tissue.. .
The Regents Of The University Of Califomia
05/21/15
20150140639

Vectors with modified initiation codon for the translation of aav-rep78 useful for production of aav


The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e.g. Adeno-associated viral) vectors in insect cells, to insect cells comprising such constructs and to methods wherein the cells are used to produce recombinant parvoviral virions.
Uniqure Ip B.v.
05/21/15
20150140636

Polynucleotides encoding mutant hydrolase proteins with enhanced kinetics and functional expression


The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.. .
Promega Corporation
05/21/15
20150140635

Boronic and borinic acid compound as inhibitors of sulfenic acid-containing proteins


A boronic or borinic acid compound is used to inhibit the activity of a sulfenic acid-containing protein. Thus, a biologically-active sulfenic acid-containing protein is contacted with an activity-inhibiting effective amount of a boronic or borinic acid compound of formula i or a salt, hydrate or solvate thereof, whose components are disclosed within, and that contact is maintained for a time sufficient to inhibit the biological activity of the protein..
05/21/15
20150140605

One step n-terminal tagging of proteins


The invention includes a selective method of modifying the n-terminus of a protein using an aminoacyl trna transferase. In certain embodiments, the method comprises contacting a solution of the protein or peptide with a transferase and a derivative of a molecule, whereby the n-terminus of the protein or peptide is derivatized with the molecule..
The Trustees Of The University Of Pennsylvania
05/21/15
20150140598

Methods of screening sulfated polysaccharides for therapeutic activity for a glycocalyx-related disease


Methods are disclosed for screening sulfated polysaccharides to identify one or more therapeutic agents that can be used for the treatment of a variety of disorders that affect the glycocalyx of a subject. A glycocalyx disease inhibitor identified by the method may increase the production of heparin sulfate or of one or more heparin sulfate proteins in the glycocalyx of at least one endothelial or other vascular cell..
05/21/15
20150140595

Formulations for the synthesis of paramagnetic particles and methods that utilize the particles for biochemical applications


A set of paramagnetic particles synthesized by co-precipitation methods wherein an alkaline hydroxide solution is mixed with a metal salt solution. The alkaline hydroxide features ammonium hydroxide, potassium hydroxide, sodium hydroxide, or mixtures thereof.
05/21/15
20150140592

Development of microorganisms for hydrogen production


Methods and compositions are provided for engineering microorganisms, which permit enhanced h2 production. The methods and compositions provided include novel chimeric gene constructs encoding h2-forming h2ase and maturation proteins, allowing for generation of h2 continuously in large quantities.
05/21/15
20150140590

Fluorescent probe for cell observation and method using same


The separase sensor of the present invention has two types of fluorescent proteins different in fluorescence wavelength at both ends of an amino acid sequence containing a separase cleavage site and a localization-targeting sequence targeting to a specific site within a cell. Since timing of activating separase and location of separase in a cell can be specified by use of the sensor, cell division can be analyzed and an anticancer agent can be screened..
05/21/15
20150140580

Antibodies to matrix metalloproteinase 9


The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (mmp9) protein (mmp9 is also known as gelatinase-b), such as where the binding proteins comprise an immunoglobulin (ig) heavy chain (or functional fragment thereof) and an ig light chain (or functional fragment thereof).. .
Gilead Biologics, Inc.
05/21/15
20150140572

Composition for use in mycobacteria diagnosis


The present invention relates to a composition having the activity of degrading the cell wall of a mycobacterium species comprising: (a) a first fusion protein including (i) a domain with a first enzymatic activity, the enzymatic activity being at least one or more of the following: n-acetyl-b-d-muramidase (lysozyme, lytic transglycosylase), n-acetyl-b-d-glucosaminidase, n-acetylmuramoyl-l-alanine amidase, l-alanoyl-d-glutamate (ld) endopeptidase, c-d-glutamyl-meso-diaminopimelic acid (dl) peptidase, d-ala-m-dap (dd) endopeptidase, or m-dap-m-dap (ld) endopeptidase, (ii) at least one peptide stretch fused to the n- or c-terminus of the domain with the first enzymatic activity; and (iii) a protein transduction domain (ptd) being at the n- or c-terminus of the first fusion protein; and (b) a second fusion protein including (i) a domain with a second enzymatic activity, the enzymatic activity being at least one or more of the following: lipolytic activity, cutinase, mycolarabinogalactanesterase, or alpha/beta hydrolase; (ii) at least one peptide stretch fused to the n- or c-terminus of the domain of the second enzymatic activity; and (iii) a protein transduction domain (ptd) being at the n- or c-terminus of the second fusion protein for use as a diagnostic agent. Moreover, the present invention relates to nucleic acid molecules encoding said fusion protein.
Lysando Ag
05/21/15
20150140185

Solvent-free approach for separation of constituent fractions of pulses, grains, oilseeds, and dried fruits


The present invention relates to a novel solvent-free process for the production of protein-, starch- and fiber-enriched fractions or fractions rich in specific compounds from pulses, grains, oilseeds, and dried fruits. Unlike conventional wet processes, this dry process preserves the natural configuration and structure of separated components.
Advanced Cert Canada Inc.
05/21/15
20150140123

Protein expression analyses for identifying genotoxic compounds


The invention relates to a method for screening compounds with (pro-)genotoxic activity by providing a system being capable of expressing a panel of defined proteins, incubating at least a portion of the system with compounds to be screened, and comparing the expression of the proteins in the system with the protein expression in a control system, thereby detecting the (pro-)genotoxic activity. Another object of the invention concerns a method for monitoring the likelihood of developing a physiological and/or pathological condition, which is caused, mediated and/or propagated by the genetic deregulation of proliferation, differentiation and/or damage repair, in response to a compound administered to a mammal in need of such treatment by determining an expression level of defined proteins in a biological sample withdrawn from the mammal.
Merck Patent Gmbh
05/21/15
20150140035

Autologous biological cancer vaccine


The present disclosure relates to an autologous biological cancer vaccine and to a method for preparing the same. The vaccine of the present application is a biological vaccine obtained from overexpressed proteins in the serum of cancer patients, proteins to which have been added immunological adjuvants such as an attenuated virus dna and amino acids in order to cause an immune response, blocking tumor cells.
Universidad Manuela Beltran
05/21/15
20150140026

Interaction of moraxella catarrhalis with epithelial cells, extracellular matrix proteins and the complement system


The present disclosure relates to surface proteins of moraxella catarrhalis and their ability to interact with epithelial cells via cell-associated fibronectin and laminin, and also to their ability to inhibit the complement system. These surface proteins are useful in the preparation of vaccines.
Arne Forsgren Ab
05/21/15
20150139999

Interferon antagonists, antibodies thereto, and associated methods of use


Described are compositions and methods useful for modulating the immune system of a subject. Also included are diagnostic methods for monitoring an immunologic condition.
Rutgers, The State University Of New Jersey
05/21/15
20150139993

Hemojuvelin fusion proteins and uses thereof


The present invention provides a hemojuvelin (hjv) fusion protein (e.g., a human hjv.fc) protein, polynucleotides and vectors encoding such proteins, and methods for making such proteins. Also provided are methods for treating iron-related disorders which include administration of a hjv fusion protein to a patient in need thereof..
The General Hospital Corporation
05/21/15
20150139988

Glycoengineered binding protein compositions


Provided are glycoengineered populations of fc domain-containing binding proteins with a reduced anti-drug immune response (ada). Also provided are methods of treating disease using such compositions, and methods and host for making such compositions..
Abbvie, Inc.
05/21/15
20150139944

Separatone-based protein expression and purification platform


Provided is a separatome-based recombinant peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic peptides, polypeptides, and proteins with the characteristics and location of the corresponding genes on the host cell chromosome, such as that of e. Coli, yeast, bacillus subtilis or other prokaryotes, insect cells, mammalian cells, etc.
Board Of Trustees Of The University Of Arkansas
05/21/15
20150139899

Neo antibodies for diagnostic imaging of tissue injury


A method for diagnosing the development of a tissue injury in a subject comprising administering a sample of neoantibodies to the subject's tissue for the purpose of detecting the presence of neoepitopes bearing complement proteins.. .
Novelmed Therapeutics, Inc.


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This listing is a sample listing of patent applications related to Proteins for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Proteins with additional patents listed. Browse our RSS directory or Search for other possible listings.
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