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Proteins patents

This page is updated frequently with new Proteins-related patent applications. Subscribe to the Proteins RSS feed to automatically get the update: related Proteins RSS feeds. RSS updates for this page: Proteins RSS RSS

Date/App# patent app List of recent Proteins-related patents
 Quantifying local inflammatory activity and its use to predict disease progression and tailor treatments patent thumbnailnew patent Quantifying local inflammatory activity and its use to predict disease progression and tailor treatments
This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting the medium with a fluid sample from a subject with an inflammatory condition, where the fluid sample comprises proteins or proteoglycans and a transfer agent; incubating the fluid sample with the medium under conditions effective for the transfer agent in the fluid sample to mediate transfer of heavy chains from the proteins or proteoglycans to the hyaluronan or a fragment thereof to form a complex; detecting, using an antibody, occurrence levels of the complex; and comparing occurrence levels of the complex from said detecting to a reference standard to predict progression of an inflammatory condition in the subject. Also disclosed are methods of tailoring treatment of an inflammatory condition and quantifying local inflammatory activity in a body fluid..
New York University

 Biomarkers for diagnosis of diabetes and monitoring of anti-diabetic therapy patent thumbnailnew patent Biomarkers for diagnosis of diabetes and monitoring of anti-diabetic therapy
The present invention relates to the use of n-linked glycan profiles of blood or blood component proteins as biomarkers for diagnosing diabetes mellitus and for monitoring the efficacy of anti-diabetic therapy. Specifically, the present invention relates to detecting changes in the amounts of n-linked glycans as diagnostic biomarkers for diabetes mellitus and as indicators of the efficacy of anti-diabetic therapy over time..
Sumitomo Bakelite Co., Ltd.

 Method of determining a protein in a sample patent thumbnailnew patent Method of determining a protein in a sample
The present invention relates to a method of determining a protein in a sample and the use of the method for the identification of aptamer target proteins.. .
Rheinische Friedrich-wilhelms Universitat Bonn

 Peptides, devices, and methods for the detection of anaplasma antibodies patent thumbnailnew patent Peptides, devices, and methods for the detection of anaplasma antibodies
The invention provides populations of isolated peptides useful for the detection of antibodies that bind to anaplasma antigens. The peptide populations comprise peptides derived from immunogenic fragments of the anaplasma outer membrane protein proteins.
Abaxis, Inc.

 Compositions and methods for rapid and reversible biomolecular labeling patent thumbnailnew patent Compositions and methods for rapid and reversible biomolecular labeling
This disclosure provides compositions and methods for a low-avidity, high-affinity and high-specificity biomolecular interaction that is rapidly reversible under physiological conditions. The methods comprise linking biological targets (such as molecules, proteins, dna, cells, etc.) with polymers and anti-polymer ligands and a way to reverse their binding using physiologically compatible polymeric compounds.
Stemcell Technologies Inc.

 Modulators of ion transport proteins or ion channels and methods of identifying and using same patent thumbnailnew patent Modulators of ion transport proteins or ion channels and methods of identifying and using same
Described herein are materials and methods for measuring intracellular ion concentrations, materials and methods for identifying modulators of intracellular ion concentrations, modulators if intracellular ion concentration, use of modulators of intracellular ion concentration to treat a disease or disorder associated with aberrant intracellular ion concentrations, and cell lines and transgenic animals that express a fluorescent ion detector and/or one or more ion transport proteins or ion channels.. .
Tufts University

 Materials for hydrophilic interaction chromatography and processes for preparation and use thereof for analysis of glycoproteins and glycopeptides patent thumbnailnew patent Materials for hydrophilic interaction chromatography and processes for preparation and use thereof for analysis of glycoproteins and glycopeptides
The invention relates to poly-amide bonded hydrophilic interaction chromatography (hilic) stationary phases and novel hilic methods for use in the characterization of large biological molecules modified with polar groups, known to those skilled in the art as glycans. The invention particularly provides novel, poly-amide bonded materials designed for efficient separation of large biomolecules, e.g.
Waters Technologies Corporation

 Liquid protein markers for native gel electrophoresis patent thumbnailnew patent Liquid protein markers for native gel electrophoresis
Marker sets are provided for use on nondenaturing gels. The protein molecular weight markers are provided in liquid form, and are stable in liquid form for at least two months at 4 degrees c.
Life Technologies Corporation

 Mutated acvr1 for diagnosis and treatment of fibrodyplasia ossificans progressiva (fop) patent thumbnailnew patent Mutated acvr1 for diagnosis and treatment of fibrodyplasia ossificans progressiva (fop)
This invention is directed to mutated activin a type i receptor proteins (acvr1) and isolated nucleic acids encoding same. The invention also relates to the use of mutated acvr1 in the diagnosis and treatment of fibrodysplasia ossificans progressiva (fop)..
The Trustees Of The University Of Pennsylvania

 Production of sialylated n-glycans in lower eukaryotes patent thumbnailnew patent Production of sialylated n-glycans in lower eukaryotes
The present invention relates to eukaryotic host cells which have been modified to produce sialylated glycoproteins by the heterologous expression of a set of glycosyltransferases, including sialyltransferase and/or trans-sialidase, to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. Novel eukaryotic host cells expressing a cmp-sialic acid biosynthetic pathway for the production of sialylated glycoproteins are also provided.
Glycofi, Inc.

new patent

Pha-producing genetically engineered microorganisms

The present invention is directed at genetically engineered form of a naturally pha producing microorganism, which has an increased number of copies, compared to the wild type microorganism, of at least one gene coding a polyhydroxyalkanoate (pha) synthase, wherein said increased number of copies provides a balanced overproduction of said pha synthase, and eventually causing the microorganism to overproduce medium- or long-chain-length phas in an amount of at least 1.2 times compared to the wild type after 24 h, wherein the reference condition for assessing the overproduction is modified mm medium containing 15 mm sodium octanoate. The production of phas in the microorganism can in addition be favourably influenced by the inactivation of genes encoding for proteins involved in the degradation of pha, resulting in an even increased production of the microorganism of this compound without a decline in the pha content over time.
Helmholtz-zentrum Fur Infektionsforschung Gmbh

new patent

Transcription activator-like effector (tale) fusion protein

The present invention relates to transcription activator-like effector (tale) derived proteins that allow to efficiently target and/or process double stranded nucleic acid sequences. The proteins of the invention are typically chimeric protein monomers composed of a core scaffold comprising repeat variable dipeptide regions (rvds) having binding specificity to a dna target sequence, to which is fused a catalytic domain to its n-terminal.

new patent

Use of a maize untranslated region for transgene expression in plants

Provided are methods, vectors and gene constructs for enhancing expression of a recombinant nucleic acid sequence in transgenic plants and plant tissues. According to the present invention, nucleic acid sequences are obtained and/or derived from the 3′ untranslated regions of genes encoding ubiquitin proteins and engineered to flank respective portions of a selected coding region of a vector.
Dow Agrosciences Llc

new patent

Method for engineering proteases and protein kinases

Provided are methods for protein engineering, such as engineering proteases or kinases. The methods may utilize yeast display and/or er sequestration of proteins or substrates.
Research Development Foundation

new patent

Compositions comprising nucleic acids encoding hiv-1 reverse transcriptase ctl epitopes

The present invention provides peptides and proteins for use in second generation hiv vaccines and as diagnostic tools in the treatment and control of hiv infection. The antiviral protection shown by compositions of the present invention has not been previously achieved with an hla epitope-enhanced vaccine.
The Government Of The United States Of America As Represented By The Secretary Of The Departmen Of H

new patent

Modified tafazzin proteins and methods of making and using the same

Fusion proteins comprising a tafazzin peptide and a cellular permeability peptide are disclosed. The tafazzin peptide may be coupled to the permeability peptide through a polypeptide linker.
University Of Washington Center For Commercialization

new patent

Compositions and methods for treating osteoarthritis

The present invention relates to the treatment of osteoarthritis in a human subject using anti-il-1α and anti-il-1β dvd-ig proteins. In various embodiments, the osteoarthritis includes knee osteoarthritis or hand osteoarthritis..
Abbvie Inc.

new patent

Mutivalent antigen-binding proteins

Multivalent antigen-binding proteins comprising two or three or four or more immunoglobulin heavy chain variable domain binding domains are provided, as are methods for making them, nucleic acid constructs, and cell lines for making them. Proteins comprising two or three or four or more different heavy chain variable domains that lack an immunoglobulin variable domain are provided.
Regeneron Pharmaceuticals, Inc.

new patent

Fusion proteins and methods thereof

The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers..
The Trustees Of Columbia University In The City Of New York

new patent

Use of dr6 and p75 antagonists to promote survival of cells of the nervous system

The present invention relates to death receptor-6 (dr6) proteins which are members of the tumor necrosis factor (tnf) receptor family, and have now been shown to be important for regulating apoptosis in cells of the nervous system. In addition, it has been discovered that p75 is a ligand for dr6.
Biogen Idec Ma Inc.

new patent

Variants of igg fc with limited amine groups

Lysine-depleted variants of fragment crystallizable (fc) regions of immunoglobulins are disclosed. Also disclosed are fusion proteins comprised of n-terminal targeting or active peptide domains fused with such lysine-depleted variant igg-fc domains.

new patent

Albumin fusion proteins

The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells.
Human Genome Sciences, Inc.

new patent

Proproteins and methods of use thereof

The present disclosure provides for proprotein and activatable proprotein compositions. A proprotein contains a functional protein (i.e.
Cytomx Therapeutics, Inc.

new patent

Aav mediated aquaporin gene transfer to treat sjogren's syndrome

The invention relates to a gene transfer-based method to protect a subject from sjogren's syndrome. The method comprises administering to the subject an aav virion comprising an aav vector that encodes aquaporin-1 (aqp-1) protein.
The Usa, As Represented By The Secretary, Dept. Of Health And Human Services

new patent

Method for the preparation of a serum protein concentrate

The present invention relates to a method for the preparation of a concentrate of serum proteins with reduced lactose content from a sample of lactoserum, wherein said concentrate is characterized in that it comprises a concentration of 0.5 grams of lactose per kilogram of protein, the concentrate obtainable from said process and food products containing said concentrate.. .
Lb Lyopharm S.r.l.

new patent

Use of p47 from plasmodium falciparum (pfs47) or plasmodium vivax (pvs47) as a vaccine or drug screening targets for the inhibition of human malaria transmission

The inventors have identified pfs47, a gene from the malaria parasite p. Falciparum, as a key factor for survival of these parasites in the mosquito anopheles gambiae.
The United States Of America, As Represented By The Secretary, Dhhs

new patent

Stabilised proteins for immunising against staphylococcus aureus

Elimination of disulphide bond formation of cysteine-containing s. Aureus antigens enhances antigen stability.
Novartis Ag

new patent

Stabilised proteins for immunising against staphylococcus aureus

Elimination of disulphide bond formation of cysteine-containing s. Aureus antigens enhances antigen stability.
Novartis Ag

new patent

Cytoplasmic tail modifications to boost surface expression and immunogenicity of envelope glycoproteins

The invention provides compositions and methods for enhanced expression of a viral envelope protein. The invention provides a composition comprising a cytoplasmic tail modification to enhance surface expression of both hiv and non-hiv viral envelope proteins as wells as other membrane associated proteins resulting in increased immunogenicity..
The Trustees Of The University Of Pennsylvania

new patent

New polyphosphate synthesis

The subject of the invention is a new method of the synthesis of polyphosphate analogues, such as nucleosides, oligonucleotides, carbohydrates, peptides and proteins, which are of biological importance and are used in organic chemistry, molecular biology and biotechnology. Polyphosphate analogues, including in particular nucleoside 5′-triphosphates, display high biological activity and are responsible for the provision and storage of energy in live organisms.
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

new patent

Cholate and deoxycholate-based amphiphiles for membrane protein manipulation

Disclosed are compounds and methods for manipulating proteins in general and membrane proteins in particular. The compounds can be prepared from cholic acid, deoxycholic acid, lithocholic acid, or derivatives thereof.
Wisconsin Alumni Research Foundation

new patent

System and optogenetic therapy

Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations.
Circuit Therapeutics, Inc.

new patent

Compositions for regenerating defective or absent myocardium

Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function..
Cormatrix Cardiovascular, Inc.

new patent

Site-specific labeling and targeted delivery of proteins for the treatment of cancer

The present invention relates to the formation of protein conjugates from proteins chemically modified for linkage to (1) anticancer drug pharmacophores, (2) ligands to biomarkers on cancer cell surfaces, (3) and/or another protein molecule. It provides and specifies new compositions, methods and combinations for tumor, and tumor vasculature targeting and cancer treatment..
Advanced Proteome Therapeutics Inc.

new patent

Stabilised proteins for immunising against staphylococcus aureus

Elimination of disulphide bond formation of cysteine-containing s.aureus antigens enhances antigen stability. The invention provides a composition comprising variant forms of cysteine-containing s.aureus antigen with a point mutation that replaces, deletes or modifies the cysteine residue..
Novartis Ag

new patent

Methods for introducing mannose 6 phosphate and other oligosaccharides onto glycoproteins and applications thereof

Methods to introduce highly phosphorylated mannopyranosyl oligosaccharide derivatives containing mannose-6-phosphate (msp), or other oligosaccharides bearing other terminal hexoses, to carbonyl groups on oxidized glycans of glycoproteins while retaining their biological activity are described. The methods are useful for modifying glycoproteins, including those produced by recombinant protein expression systems, to increase uptake by cell surface receptor-mediated mechanisms, thus improving their therapeutic efficacy in a variety of applications..
Genzyme Corporation

new patent

Targeted oesophageal administration of zn-alpha2-glycoproteins (zag), methods and formulations thereof

The invention provides formulations and methods for ameliorating symptoms associated with metabolic disorders, such as hypoglycemia, obesity, diabetes, and the like by targeted administration to the oesphagus of a subject of zn-α2-glycoproteins or a functional fragment thereof, alone or in combination with additional agents, such as β adrenergin receptor agonists, β adrenergin receptor antagonists, and/or glycemic control agents.. .
Aston University

new patent

Treatment of spinal cord injury or traumatic brain injury by inhibition of amyloidogenic proteins and synuclein protein accumulation or aggregation

Methods for the treatment of spinal cord injury or traumatic brain injury are provided. In certain embodiments, the methods include the use of a molecular tweezers and/or nucleobase oligomer capable of inhibiting the accumulation or aggregation of one or more amyloidogenic proteins and/or synuclein proteins.
Board Of Regents, The University Of Texas System

new patent

Pharmaceutical compositions of anisomelic acid and the use thereof

A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of anisomelic acid or salts thereof. The pharmaceutical composition may comprise anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a co-solvents or surfactant or a combination thereof.

new patent

Production technology of fat mixes with reduced fat content

A method of production of a fat mix with a decreased fat content, consisting in cream separation from milk, fat content normalisation, pasteurisation, preparation of a cream mixture with milk powder and/or other protein carriers, pasteurisation of the mixture, refrigeration, homogenisation, addition of starters, souring, introduction of the other condensing and flavour additives, thermisation, smoothing homogenisation, hot packing is characterised by the fact that pasteurised, normalised cream, supplemented or not with an addition of recombined cream, is completed with milk protein carriers and the entire mixture is submitted to thermal processing in 85-135° c. For 10-180 seconds, degassed, cooled down to 30-55° c., supplemented with transglutaminase in solution or solid form, in a quantity of 0.1-20.0 u/g of the protein, then the entire product is kept in this temperature for 15-70 minutes, followed by thermal processing in 70-92° c.
Pmt Trading Sp. Z.o.o.


Alzheimer's disease diagnostic panels and methods for their use

Novel compositions, methods, assays and kits directed to a diagnostic panel for alzheimer's disease are provided. In one embodiment, the diagnostic panel includes one or more proteins associated with alzheimer's disease..
Integrated Diagnostics, Inc.


Isotopic labelling of proteins

The present invention provides methods for enhancing the synthesis of isotope labelled native proteins in specific biological pathways for the purpose of protein quantification and qualification. The invention provides reference samples for use in various mass-spectrometry-based methods of protein analysis..
University Of Dundee


Microfluidic glycan analysis

Microfluidic devices and methods for analyzing glycan profiles of glycoproteins are provided. Some embodiments of the devices comprise a deglycosylation column for cleaving glycans, an optional cleaning column for removing proteins, a trapping column for enriching glycans, and a separation column for resolving glycans.
Agilent Technologies, Inc.


Use of antibody-surrogate antigen systems for detection of analytes

Compositions, methods and kits for labeling proteins and uses in reporter systems for detecting, quantifying and/or characterizing analytes.. .
Applied Biosystems, Llc


Method and system of microfluidic immunoassay using magnetic beads

A microfluidic western blot method and system including a microfluidic western blot method for immunoassay of proteins, the method including introducing a sample including the proteins onto a chip; electrophoretically separating the proteins; binding the separated proteins to beads to form protein-attached beads, the beads being magnetic; flowing the protein-attached beads into a magnetic holding region; applying a magnetic field to the magnetic holding region to fix the protein-attached beads in place within the magnetic holding region; binding primary antibodies to target proteins on the protein-attached beads; binding secondary antibodies to the bound primary antibodies; and detecting the bound secondary antibodies.. .
Caliper Life Sciences, Inc.


Lucigen yellow (lucy), a yellow fluorescent protein

Described herein are isolated polynucleotides that encode a fluorescent protein which is at least 80% sequence identical to a protein selected from the group consisting of seq. Id.
Lucigen Corporation


Methods for enhancing the degradation of cellulosic material with chitin binding proteins

The present invention relates to methods for degrading or converting a cellulosic material and for producing substances from the cellulosic material.. .
Novozymes, Inc.


Novel bacillus thuringiensis genes with lepidopteran activity

The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests, including lepidoptera. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, dna constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments.
Pioneer Hi Bred International, Inc.


Methods and compositions for production of recombinant pharmaceutical proteins in medicinal plants

Methods of tissue culture and in vitro propagation of medicinal plants, in particular, plants of the genera hydrastis, echinacea, kalanhoe, thymus and calendula are described. Methods of genetically engineering the medicinal plants are also described, along with methods of producing recombinant proteins in such plants.
Pharma Green Llc


Isolated novel nucleic acid and protein molecules from soybeans and methods of using those molecules to generate transgenic plants with enhanced agronomic traits

This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing dna for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants..
Monsanto Technology Llc


Transgenic plants with enhanced agronomic traits

This invention provides transgenic plant cells with recombinant dna for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil.
Monsanto Technology Llc


Fusion proteins and methods for treating, preventing or ameliorationg pain

A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, which protease is capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a galanin targeting moiety that is capable of binding to a binding site on the nociceptive sensory afferent, which binding site is capable of undergoing endocytosis to be incorporated into an endosome within the nociceptive sensory afferent; a protease cleavage site at which site the fusion protein is cleavable by a protease, wherein the protease cleavage site is located between the non-cytotoxic protease and the galanin targeting moiety; a translocation domain that is capable of translocating the protease from within an endosome, across the endosomal membrane and into the cytosol of the nociceptive sensory afferent; a first spacer located between the non-cytotoxic protease and the protease cleavage site, wherein said first spacer comprises an amino acid sequence of from 4 to 25 amino acid residues; and a second spacer located between the galanin targeting moiety and the translocation domain, wherein said second spacer comprises an amino acid sequence of from 4 to 35 amino acid residues. Nucleic acid sequences encoding the polypeptide fusion proteins, methods of preparing same and uses thereof are also described..
Allergan, Inc.


Variant forms of urate oxidase and use thereof

Genetically modified proteins with uricolytic activity are described. Proteins comprising truncated urate oxidases and methods for producing them, including pegylated proteins comprising truncated urate oxidase are described..
Crealta Pharmaceuticals Llc


Pulse combustion drying of proteins

Methods for pulse combustion spray drying of heat-sensitive protein compositions using high temperature pulsating jets to atomize and dry the feed simultaneously are described herein. Methods and compositions described herein provide dried protein-containing compositions with low protein denaturation and other useful functional properties at high operational efficiencies..
Pulse Holdings, Llc


Selective efflux inhibitors and related pharmaceutical compositions and methods of treatment

The present invention provides novel compounds which inhibit cancer-associated transporter proteins, methods of treating or preventing the onset of a cancer-associated transporter protein-mediated disease by administering such compounds, and pharmaceutical compositions comprising such compounds. In one embodiment, the invention provides novel pyrazolo[1,5-a]pyrimidine efflux inhibitors that are selective toward abcg2 over abcb1..
University Of Kansas


Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation

Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and optionally including proteins. In one aspect, hyaluronic acid-based compositions described herein include zero-length cross-linked moieties and optionally at least one active agent.
Allergan, Inc.


Fusion proteins containing insulin-like growth factor-1 and epidermal growth factor and variants thereof and uses thereof

Fusion proteins comprising cytokines, particularly insulin-like growth factor-1 (igf-1) and variants thereof, epidermal growth factor (egf), and other ligands to the egf receptor, are provided. The fusion proteins further comprise seq id no:1 or other segments having lysine, glutamic acid, or aspartic acid residues.


Hypo-allergenic cross-linked proteins for use in the prevention of an allergy against milk-proteins and for use in the induction of oral tolerance

The present invention provides a hypo-allergenic cross-linked protein for use in the prevention of an allergy against milk proteins, or for use in the induction of oral tolerance for milk proteins, said cross-linked protein being selected from cross-linked casein, cross-linked caseinate and combinations thereof. The invention further provides a nutritional composition for use in the prevention of an allergy against milk proteins or for use in the induction of oral tolerance against milk proteins..
Friesland Brands B.v.


Rift valley fever virus replicon particles and use thereof

Disclosed herein is a robust system for the reverse genetics generation of a rift valley fever (rvf) virus replicon particle (vrprvf) vaccine candidate. Vrprvf can actively synthesize viral rna and proteins, but lack structural glycoprotein genes, preventing spread within immunized individuals and reducing the risk of vaccine-induced pathogenicity.
The Government Of The United States Of America As Represented By The Secretary Of The Department Of


Formulations for alteration of biophysical properties of mucosal lining

Conductive formulations containing conductive agents, such as salts, ionic surfactants, or other substances that are in an ionized state or easily ionized in an aqueous or organic solvent environment, and methods of use, have been developed. One or more active agents, such as antivirals, antimicrobials, anti-inflammatories, proteins or peptides, may optionally be included with the formulation.
Pulmatrix, Inc.


Treatment of mitochondria-related diseases and improvement of age-related metabolic deficits

Pharmaceutical compositions and methods for the treatment of subjects, including humans, who have or are at risk for various disease, disorders and conditions, including, mitochondria-associated diseases, disorders, and conditions, including respiratory chain disorders, and diseases, disorders and conditions associated with or characterized at least in part by mitochondria swelling, mitochondria dysfunction, mitochondria leaking, oxidative stress, increased mitochondria number, increased mitochondria and mitochondria-related protein mass, and increased mitochondria and related-related proteins expression.. .
Philera New Zealand Limited


Endosseous dental implant assembly

An endosseous dental implant assembly comprises a dental implant comprising an abutment portion for connecting to a tooth crown and a hollow base portion defining a cavity therein, and a bio-supportive or biodegradable scaffold carried by the hollow base portion of the dental implant in the biomimetic approach. The abutment portion is formed integrally with the hollow base portion.


Novel chemistry used in biosensors

The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.. .
Ohmx Corporation


Sensitive method to analyse free peg-maleimide

The present invention relates generally to a novel method using hplc and fluorescence detection of free peg-mal in pegylated proteins and peg-mal raw materials by adding a fluorescent label to the free peg-mal.. .
Bristol-myers Squibb Company


Hoxc6 and ovarian cancer methods and uses thereof

The present invention comprises novel methods, systems, devices, and kits to detect cancer in a patient using hoxc6. Methods and systems are presented herein to (1) determine differential gene expression in cancer tissue (e.g.
The Charlotte-mecklenburg Hospital Authority D/b/a Carolinas Healthcare System


Process and improving the water reuse, energy efficiency, fermentation and products of a fermentation plant

A method of improving fermentation, by heating stillage to a temperature of 200 degrees f. To 350 degrees f.


Lentiviral triplex dna, and vectors and recombinant cells containing lentiviral triplex dna

The present invention provides nucleic acid, vectors, viruses, and recombinant cells comprising triple-stranded structures, such as those resulting from central initiation and termination of hiv-1 reverse transcription at the center of hiv-1 linear dna genomes. These triplex structures can act as a cis-determinant of hiv-1 dna nuclear import, allowing infection of non-dividing target cells.
Institut National De La Sante Et De La Recherche Medicale


Lepidopteran insect n-acetylglucosaminidase genes and their use in glycoengineering

A transgenic insect cell line for production of elevated levels of recombinant glycoproteins comprising mammalian-like n-glycans is provided. Also disclosed is a nucleic acid sequence encoding n-acetylglucosaminidase..
University Of Wyoming


Expression of maize codon optimized proteins in pseudomonas fluorescens

Compositions and methods for improving expression of a recombinant protein or polypeptide of interest in a host cell are provided. Compositions comprising a polynucleotide coding sequence for a btbooster are provided using a plant optimized system.
Dow Agrosciences Llc


Generation of native recombinant secreted human endoplasmic reticulum chaperones by using their native signal sequences in yeast expression systems

A method using yeast as a host for production of human er chaperone proteins, using endogenous signal peptides of intracellular human proteins that are recognized and correctly processed in the yeast cells to subsequently lead to the secretion of the human proteins. The resultant proteins possessed native amino acid sequence and were biologically active.
Uab Baltymas


Antibodies specific for sclerostin and methods for increasing bone mineralization

Compositions and methods relating to antibodies that specifically bind to tgf-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a tgf-beta binding protein sclerostin and a tgf-beta superfamily member, particularly a bone morphogenic protein.
Ucb Pharma S.a.


Antibody for epitope tagging, hybridoma cell line and uses thereof

There are provided peptide tags derived from bacteriophytochrome (bphp) that is photoreceptor protein of deinococcusradiodurans, an antibody capable of specifically recognizing the peptide tags, hybridoma cell lines capable of producing the antibody, and uses thereof. The novel peptide tag has advantages in that it has a short length and can remove a non-specific reaction of the conventional c-myc tag and flag tag.
Myongi University Industry And Academai Cooperatio Foundation


Compositions and methods for modulating biomass productivity

The disclosure generally relates to methods and materials for modulating cell productivity. In particular, the present disclosure provides polynucleotides encoding transcription factor proteins that when overexpressed in microrganisms result in increased in productivity, such as increased biomass productivity.
Synthetic Genomics, Inc.


Stabilised proteins for immunising against staphylococcus aureus

Elimination of disulphide bond formation of cysteine-containing s. Aureus antigens enhances antigen stability.
Novartis Ag


Compositions and methods for the treatment or prevention of hepatitis b virus infection

Disclosed are yeast-based immunotherapeutic compositions, hepatitis b virus (hbv) antigens, and fusion proteins for the treatment and/or prevention of hbv infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, hbv antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of hbv and/or symptoms thereof.. .
Globelmmune, Inc.


Anti-proliferative compounds and uses thereof

The present invention provides novel compounds of formula (i), and pharmaceutically acceptable salts, tautomers, stereoisomers, solvates, hydrates, polymorphs, and compositions thereof. Also provided are methods and kits involving the inventive compounds for treating proliferative diseases (e.g., cancers (e.g., breast cancer, prostate cancer, lung cancer, and ovarian cancer), benign neoplasms, angiogenesis, inflammatory diseases, and autoimmune diseases) in a subject.
The General Hospital Corporation D/b/a Massachusetts General Hospital


Compositions and methods for treatment of hyperplasia

In accordance with the present invention, there are provided methods for treating hyperplasia in a subject in need thereof. In another aspect of the invention, there are provided methods for reducing neointimal hyperplasia associated with vascular interventional procedures.
Abraxis Bioscience, Llc


Methods and compositions for raising an immune response to hiv

A method of raising an immune response in an individual against human immunodeficiency virus (hiv) the method comprising: (a) administering to the individual dna or sfv encoding an hiv env protein and optionally nucleic acid encoding one, any two or all three of the hiv gag, pol and nef proteins; (b) subsequently administering to the individual viral vector encoding an hiv env protein and optionally viral vector encoding one, any two or all three of the hiv gag, pol and nef proteins; and (c) administering to the individual oligomeric hiv env protein; and an adjuvant.. .
Imperial Innovations Limited


Biosynthetic system that produces immunogenic polysaccharides in prokaryotic cells

The invention is directed to bioconjugate vaccines comprising n-glycosylated proteins. Further, the present invention is directed to a recombinant prokaryotic biosynthetic system comprising nucleic acids encoding an epimerase that synthesizes an oligo- or polysaccharide having n-acetylgalactosamine at the reducing terminus.
Glycovaxyn Ag


Igf-1 proteins and therapeutic uses thereof

The present disclosure provides for techniques using pro-igf-i for increasing igf-i activity. Accordingly, the present disclosure provides for compositions and methods for treating or preventing a disease or disorder mediated by igf-i.
The Trustees Of The University Of Pennsylvania


Method for producing a protein comprising composition with reduced digestive coagulation

The present invention relates to a process of producing a composition comprising at least two different proteins, of which at least one is a coagulating protein and at least one is an anti-coagulating protein, comprising the steps of: a) heat-sterilising a first liquid component comprising said coagulating protein, b) heat-sterilising a second liquid component comprising said anti-coagulating protein, and c) mixing said first component with said second component to obtain a mixture thereof. The obtained mixture is useful as a food constituent having reduced coagulation in the upper gastro-intestinal tract, more in particular in the stomach..
N.v. Nutricia


Method of reducing injury to mammalian cells

A method of inhibiting the binding between n-methyl-d-aspartate receptors and neuronal proteins in a neuron is disclosed. The method comprises administering to the neuron an effective inhibiting amount of a peptide replacement agent for the nmda receptor or neuronal protein interaction domain that effect said inhibition of the nmda receptor-neuronal protein interaction.
Nono Inc.


Bi-functional co-polymer use for ophthalmic and other topical and local applications

The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided..
Eyeon Particle Sciences Llc


Innate immune proteins as biomarkers for cns injury

The present invention provides novel markers of the severity of a central nervous system injury, such as spinal cord injury or traumatic brain injury, in a patient. In particular, protein components of inflammasomes in the cerebrospinal fluid that can be used to assess the severity of central nervous system injury in a patient are disclosed.
University Of Miami


Method for diagnosing scleroderma

The present invention relates to an in vitro method for diagnosing scleroderma in a subject, said method comprising the step of detecting in a biological sample obtained from the subject one or more autoantibodies recognizing one or more protein biomarkers selected from the group of proteins consisting of thex1, aif1, fgf2, ephb2, clk1 and anks6.. .
Université D'aix Marseille


Systemic discovery, maturation and extension of peptide binders to proteins

The invention comprises systems, methods and arrays for identification and optimization of novel peptide binders to protein targets. Embodiments include steps of peptide binder discovery, core peptide maturation, n-terminal and c-terminal extension and kinetics analysis of the final peptide binder..
Roche Nimblegen Inc.


Single molecule protein sequencing

The invention provides a device for determining the type of protein in a liquid, the device comprising (a) an immobilized atp dependent protease based molecular transporter machine configured to guide a protein that is functionalized with labels through a detection area of a detector, (b) said detector, configured to detect a signal as function of the labels of the labelled amino acids, (c) a processor unit, configured to identify from the detector signal a sequence of amino acids of the functionalized protein, wherein the processor unit is further configured to compare the identified sequence of amino acids with the occurrence of such sequence in a database of proteins and to identify the type of protein.. .
Technische Universiteit Delft


Separation of proteins

The disclosure relates to a method for the selective separation of proteins from liquid biological materials which, based on the total quantity, contain a small proportion of one or more trace components, by means of the addition of polar organic solvents having a dipole moment in the range from 1.6 to 4.0 debye, and adsorption of the proteins on a solid phase carrier, wherein the trace components are separated from the proteins bound to the solid phase carrier by adsorption by means of a) magnetic field, b) centrifugal force, c) gravitational force or d) compressive force, and the trace components remain in the liquid.. .
Magnamedics Gmbh

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