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Proteins

Proteins-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Development and use of cysteine-labeled fluorescent probes of unbound analytes
Alan Kleinfeld
February 15, 2018 - N°20180045742

A method for high throughput discovery of proteins fluorescently labeled at a cysteine residue and that undergo a change in fluorescence ratio at 2 wavelengths upon binding an unbound analyte is described. Probes are disclosed which are labeled at a cysteine residue and also probes labeled at both cysteine and lysine with two different fluorophores. These probes are useful for characterization ...
Methods of use for intermediate filament protein probes
University Of Connecticut
February 15, 2018 - N°20180045738

The present disclosure relates to compounds and methods for labeling and/or detecting proteins in vivo, and methods for probing mitochondrial structure and/or dynamics.
Methods for detecting adverse local tissue reaction (altr) necrosis
February 15, 2018 - N°20180045737

This invention relates to field of screening and diagnosing adverse local tissue reaction (altr) in a subject who has received a joint replacement by measuring the level of a nucleic acid or protein biomarker that are elevated in patients suffering from altr, even those with no symptoms. The early diagnosis of the altr can lead to its treatment and thus, ...
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  • 271+ full patent PDF documents of Proteins-related inventions.
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Mutant smoothened and methods of using the same
Universite Paris Diderot - Paris 7
February 15, 2018 - N°20180045729

The emergence of mutations in tyrosine kinases following treatment of cancer patients with molecular-targeted therapy represents a major mechanism of acquired drug resistance. Here, mutations in the serpentine receptor, smoothened (smo) are described, which result in resistance to a hedgehog (hh) pathway inhibitor, such as in medulloblastoma. Amino acid substitutions in conserved residues of smo maintain hh signaling, but result ...
Analysis of genomic dna, rna, and proteins in exosomes for diagnosis and theranosis
Board Of Regents, The University Of Texas System
February 15, 2018 - N°20180045728

The present invention provides that exosomes from human body fluid samples contain double stranded genomic dna that spans all chromosomes and may be used to determine the mutation status of genes of interest in diseases, such as cancer. Furthermore, the present invention provides the use of exosomes to produce therapeutic proteins and for their use in therapy as well as ...
Methods of detecting inflammatory markers and treating inflammatory conditions in humans
Vetica Labs, Inc.
February 15, 2018 - N°20180045724

The present invention provides methods and systems to accurately detect and measure in a biological sample from a patient, endogenous antibodies, e. G., iga, to inflammatory proteins, which antibodies are useful as diagnostic markers for inflammatory conditions, including bowel disease (ibd), in patients. Such methods and systems identify whether a sample from the patient is associated with an inflammatory condition, ...
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Proteins Patent Applications
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inventor
  • 271+ full patent PDF documents of Proteins-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Structure and function of the salicyclic acid binding sites on human hmgb1 and methods of ...
Ospedale San Raffaele
February 15, 2018 - N°20180045715

Compositions and methods for identifying agents which 1) mimic salicyclic acid binding to human, animal and plant high mobility group box proteins or 2) alter activities of these hmgbs by binding in or around their salicyclic acid-binding sites and agents so identified are disclosed.
Microarray slides that enhance fluorescent signals via plasmonic interaction
Biochemistry
February 15, 2018 - N°20180045644

The invention describes generating and use of a multi-layer plasmonic slide, wherein the plasmonic slide comprises at least 6 layers of metallic nanoparticles that can enhance the detection of fluorescent signals and wherein the plasmonic slide can be printed as a microarray of any size. The microarray containing the plasmonic slide can further be printed with a protein, a glycan, or ...
Coating composition comprising hydrolysed wheat proteins
Syral Belgium Nv
February 15, 2018 - N°20180044858

A paper or cardboard coating composition having a dry matter content of between 45% and 80%, comprising i) binders which include at least one modified starch and one adhesive, ii) a hydrolyzed wheat protein having an average molecular weight of between 7 and 1000 kda, and iii) a mineral filler, and also the method for obtaining such a composition. A method for coating or ...
Polynucleotide binding protein sequencing
Stratos Genomics, Inc.
February 15, 2018 - N°20180044725

The present disclosure relates to systems, methods and compositions for single molecule electronic sequencing of template nucleic acids using nanosensors. The nanosensors of the invention improve the measurement of polynucleotides by assimilating authentic polynucleotide binding proteins (“pbps”) in place of conventional pore-forming proteins that do not normally interact with polynucleotides. The pbps of the present invention ...
Use of phenolic antioxidants in cell culture for the production of proteins
Bristol-myers Squibb Company
February 15, 2018 - N°20180044709

The present invention relates to new methods and processes for culturing mammalian cells with the addition of phenolic antioxidants. Performance of the cell culturing methods and processes in their various aspects result in a higher viable cell density and higher protein titer.
Methods and compositions for gene expression in plants
Monsanto Technology Llc
February 15, 2018 - N°20180044690

The invention provides recombinant dna molecules useful for providing efficient expression of proteins in transgenic plants, as well as compositions and methods for using the recombinant dna molecules. In particular embodiments, the invention provides recombinant dna molecules and constructs comprising sequences encoding transit peptides and operably linked sequences conferring herbicide tolerance.
Biofunctional materials
The University Of Akron
February 15, 2018 - N°20180044658

The present invention relates to compositions and processes in the field of self-cleaning system using digestive proteins. One composition includes a substrate, a digestive protein capable of decomposing a stain molecule, and a linker moiety bound to both said digestive protein and said substrate. The processes include binding a substrate to a surface and forming a linker moiety between a ...
Proteins Patent Pack
Download 271+ patent application PDFs
Proteins Patent Applications
Download 271+ Proteins-related PDFs
For professional research & prior art discovery
inventor
  • 271+ full patent PDF documents of Proteins-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Selective oxidation of 5-methylcytosine by tet-family proteins
The United States Of America, As Represented By The Secretary, Department Of Health & Human Servic
February 15, 2018 - N°20180044633

The present invention provides for novel methods for regulating and detecting the cytosine methylation status of dna. The invention is based upon identification of a novel and surprising catalytic activity for the family of tet proteins, namely tet1, tet2, tet3, and cxxc4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine ...
Selective oxidation of 5-methylcytosine by tet-family proteins
The United States Of America, As Represented By The Secretary, Department Of Health & Human Servic
February 15, 2018 - N°20180044632

The present invention provides for novel methods for regulating and detecting the cytosine methylation status of dna. The invention is based upon identification of a novel and surprising catalytic activity for the family of tet proteins, namely tet1, tet2, tet3, and cxxc4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine ...
Adhesives from renewable feedstocks
Purdue Research Foundation
February 15, 2018 - N°20180044469

Disclosed herein is a novel copolymer: poly [(3,4-dihydroxymandelic acid)-co-(lactic acid)]. This novel copolymer can be produced from renewable feedstocks, possesses tunable degradation, and can achieve adhesion strengths rivaling the performance of existing glues and adhesives. In one aspect, a polymer is presented. The polymer includes poly[(3,4-dihydroxymandelic acid)-co-(lactic acid)]. The polymer can be an adhesive. The ...
Polymeric fc proteins and methods of screening to alter their functional characteristics
Ucb Biopharma Sprl
February 15, 2018 - N°20180044416

The invention relates to polymeric fc proteins which bind to human fc-receptors and methods of screening said polymeric fc proteins to alter their functional characteristics. The invention also relates to therapeutic compositions comprising the polymeric fc proteins, and their use in the treatment of immune disorders.
Antibody-mediated transduction of heat shock proteins into living cells
The Department Of Veterans Affairs
February 15, 2018 - N°20180044409

The invention provides for a fusion protein comprising a 3e10 fv joined to a hsp-70, hsp-27, hsp-90 or grp-78 or portion thereof, and optionally, the 3e10 fv comprising an amino acid sequence agih at its amino terminus.
Immunomodulatory fusion proteins and uses thereof
Fred Hutchinson Cancer Research Center
February 15, 2018 - N°20180044404

The present disclosure relates to immunomodulatory fusion proteins containing an extracellular binding domain and an intracellular signaling domain, wherein binding of a target can generate a modulatory signal in a host cell, such as a t cell. The present disclosure also relates to uses of immune cells expressing such immunomodulatory fusion proteins to treat certain diseases, such as cancer or ...
Fusion proteins comprising a binding protein and an interleukin-15 polypeptide having a reduced affinity for ...
Eberhard Karls UniversitÄt TÜbingen
February 15, 2018 - N°20180044391

The present invention relates to fusion proteins comprising a binding protein and an il-15 polypeptide as well as uses thereof, pharmaceutical compositions comprising such fusion proteins and a method for producing such fusion proteins.
Compositions for regulating iron homeostasis and methods of using same
The General Hospital Corporation
February 15, 2018 - N°20180044389

The present invention relates to hemojuvelin-igg fc domain fusion proteins, variants, derivatives, fragments and peptide mimetics derived therefrom and methods of using these fusion proteins for the regulation of iron homeostasis and the treatment of diseases related to iron homeostasis.
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