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Proteins patents



      
           
This page is updated frequently with new Proteins-related patent applications. Subscribe to the Proteins RSS feed to automatically get the update: related Proteins RSS feeds. RSS updates for this page: Proteins RSS RSS


Dimeric protein with triple mutations

Genmab B.v.

Dimeric protein with triple mutations

Dimeric protein with triple mutations

Father Flanagan's Boys' Home Doing Business As Boys Town National Research Hospital

Rac1 inhibitors for the treatment of alport glomerular disease

Date/App# patent app List of recent Proteins-related patents
06/25/15
20150177275
 Scanning probe microscope and measuring method using same patent thumbnailnew patent Scanning probe microscope and measuring method using same
Provided is a scanning probe microscope that takes measurements at high spatial resolution on physical information such as array structure of water molecules at a specimen-culture fluid interface in a culture fluid as well as irregularities of the surface of a specimen and composition distribution and array structure of molecules, proteins, etc. Even in the atmosphere, an ambient air, vacuum, among others.
Hitachi, Ltd.
06/25/15
20150177254
 Boron-containing 5-arylidene-3,5-dihydro-4h-imidazol-4-ones patent thumbnailnew patent Boron-containing 5-arylidene-3,5-dihydro-4h-imidazol-4-ones
Are introduced, containing 5-arylidene-3,5-dihydro-4h-imidazol-4-one core. These compounds can be used for fluorescent staining of cell membranes, biomolecules' labeling in vivo and in vitro, a number of compounds also have photoacidic properties.
06/25/15
20150177240
 Nogo receptor binding protein patent thumbnailnew patent Nogo receptor binding protein
The invention provides sp35 polypeptides and fusion proteins thereof, sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides compositions comprising, and methods for making and using, such sp35 antibodies, antigen-binding fragments thereof, sp35 polypeptides and fusion proteins thereof..
Biogen Idec Ma Inc.
06/25/15
20150177238
 Process for the manufacturing of glycochips patent thumbnailnew patent Process for the manufacturing of glycochips
The present invention relates to a process for the manufacturing of solid supports functionalized by saccharide type molecules (glycochips or carbohydrate arrays or alternatively oligosaccharide arrays). The present invention also relates to the glycochips directly obtained by such a manufacturing process and to their use, in particular for biological analysis and especially for the screening of saccharides or proteins such as hepatocyte growth factors (hgfs) or for the study of saccharides/proteins interactions..
Azbil Corporation
06/25/15
20150177199
 Method and  characterizing impurity profile of organic materials patent thumbnailnew patent Method and characterizing impurity profile of organic materials
Method and apparatus for characterizing drug-modified polymers, macromolecules, proteins, antigens, antibodies or nanoparticles and quantitative determination of their impurity profile by two-dimensional liquid chromatography analysis. The first dimension is preferably size exclusion chromatography (sec)—which is also known as gel permeation chromatography in case of non-aqueous samples (gpc)—for complete molecular weight analysis of nanoscale particles.
Bbs Nanotechnology Ltd.
06/25/15
20150176062
 Method for providing dna fragments derived from an archived sample patent thumbnailnew patent Method for providing dna fragments derived from an archived sample
Aspects of the present invention relate to compositions and methods for providing dna fragments from an archived sample (e.g., paraffin-embedded and/or fixed-tissue biopsies, etc.). Particular aspects provide methods whereby high yields of dna are isolated as well as a substantial portion of the dna consists of long dna fragments, and where the isolated genomic dna is free of associated or cross-linked contaminants like proteins, peptides, amino acids or rna.
Epigenomics Ag
06/25/15
20150176045
 Method for in vivo production of deglycosylated recombinant proteins used as substrate for downstream protein glycoremodeling patent thumbnailnew patent Method for in vivo production of deglycosylated recombinant proteins used as substrate for downstream protein glycoremodeling
The present invention includes compositions and methods of reducing the glycosylation of proteins comprising: obtaining a cell that expresses one or more proteins that comprise one or more glycosylation sites and are glycosylated; expressing in the cell one or more glycosidases that cleaves one or more glycosyl groups from the one or more proteins; and isolating the one or more proteins with reduced glycosylation from the cell.. .
Caliber Biotherapeutics, Llc
06/25/15
20150176044
 Production of fucosylated glycoproteins patent thumbnailnew patent Production of fucosylated glycoproteins
Described herein are compositions including filamentous fungal cells, such as trichoderma fungal cells, having reduced protease activity and expressing fucosylation pathway. Further described herein are methods for producing a glycoprotein having fucosylated n-glycan, using genetically modified filamentous fungal cells, for example, trichoderma fungal cells, as the expression system..
Novartis Ag
06/25/15
20150176022
 Herbicide-resistant sunflower plants, polynucleotides encoding herbicide=resistant aceto hydroxy acid synthase large subunit proteins, and methods of use patent thumbnailnew patent Herbicide-resistant sunflower plants, polynucleotides encoding herbicide=resistant aceto hydroxy acid synthase large subunit proteins, and methods of use
Herbicide-resistant sunflower plants, isolated polynucleotides that encode herbicide-resistant and wild-type acetohydroxyacid synthase large subunit (ahasl) polypeptides, and the amino acid sequences of these polypeptides, are described. Expression cassettes and transformation vectors comprising the polynucleotides of the invention, as well as plants and host cells transformed with the polynucleotides, are described.
Basf Aktiengesellschaft
06/25/15
20150176020
 Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases patent thumbnailnew patent Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases
The present invention relates to non-mammalian β-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian β-1,4-galactosyltransferases and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation.
Stichting Dienst Landbouwkundig Onderzoek
06/25/15
20150176018
new patent

Novel eto1 genes and use of same for reduced ethylene and improved stress tolerance in plants


The invention provides isolated ethylene over-producer 1 (eto1) nucleic acid molecules which are associated with ethylene production in plants and their encoded proteins. The present invention provides methods and compositions relating to altering ethylene production and abiotic stress response in plants.
Pioneer Hi-bred International Inc.
06/25/15
20150176014
new patent

Sugar transport sequences, yeast strains having improved sugar uptake, and methods of use


Disclosed are nucleic acid constructs comprising coding sequences operably linked to a promoter not natively associated with the coding sequence. The coding sequences encode pichia stipitis proteins that allow recombinant strains of saccharomyces cerevisiae expressing the protein to grow on xylose, and allow or increase uptake of xylose by pichia stipitis or saccharomyces cerevisiae expressing the coding sequences.
Wisconsin Alumni Research Foundation
06/25/15
20150176002
new patent

Human lambda light chain mice


Genetically modified mice are provided that express human λ variable (hvλ) sequences, including mice that express hvλ sequences from an endogenous mouse λ light chain locus, mice that express hvλ sequences from an endogenous mouse κ light chain locus, and mice that express hvλ sequences from a transgene or an episome wherein the hvλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins.
Regeneron Pharmaceuticals, Inc.
06/25/15
20150175987
new patent

Endoglucanases with improved properties


The present invention relates to thermostable endoglucanases, particularly to proteins having endoglucanase activity which comprises an amino acid sequence having at least 96% identity to seq. Id no.: 2, and proteins having endoglucanase activity which belongs to the gh7 class and which shows active thermostabilization..
Clariant Produkte (deutschland Gmbh
06/25/15
20150175980
new patent

Novel cell wall deconstruction enzymes of scytalidium thermophilum, myriococcum thermophilum, and aureobasidium pullulans, and uses thereof


The present invention relates to novel polypeptides and enzymes (e.g., thermostable proteins and enzymes) having activities relating to biomass processing and/or degradation (e.g., cell wall deconstruction), as well as polynucleotides, vectors, cells, compositions and tools relating to same, or functional variants thereof. More particularly, the present invention relates to secreted enzymes that may be isolated from the fungi, scytalidium thermophilum strain cbs 625.91, myriococcum thermophilum strain cbs 389.93, and aureobasidium pullulans strain atcc 62921.
Concordia University
06/25/15
20150175707
new patent

Dimeric protein with triple mutations


The present invention relates to dimeric proteins comprising amino acids at three different positions which are different from those present in a human igg1. Six of said dimeric proteins are capable of forming a hexameric structure in solution..
Genmab B.v.
06/25/15
20150175695
new patent

Rac1 inhibitors for the treatment of alport glomerular disease


The present invention provides methods of treating alport syndrome in a subject by the administration of an agent that can blocks the activation of rac1/cdc42 members of the rho family of small gtpases. Such agents include, but are not limited to, the endothelin receptor antagonists such as bosentan and letairis and neutralizing antibodies to endothelin-1.
Father Flanagan's Boys' Home Doing Business As Boys Town National Research Hospital
06/25/15
20150175692
new patent

Anti-il-17a antibodies and their use in treating autoimmune and inflammatory disorders


The present disclosure relates to antibodies and proteins comprising an antigen-binding portion thereof that specifically bind to the pro-inflammatory cytokine il-17a. The disclosure more specifically relates to specific antibodies and proteins that are il-17a antagonists (inhibit the activities of il-17a and il-17af) and are capable of inhibiting il-17a induced cytokine production in in vitro assays, and having an inhibitory effect in an antigen-induced arthritis model in vivo.
Novartis Ag
06/25/15
20150175683
new patent

Binding molecules targeting pathogens


A first aspect of the disclosure relates to the field of binding molecules targeted at pathogens. The disclosure further relates to proteinaceous binding molecules targeting cells displaying pathogen-associated molecular patterns, in particular targeting cell surface molecules associated with or derived from pathogens, more in particular cell surface proteins displaying peptides from intracellular (pathogen associated) proteins..
Apo-t B.v.
06/25/15
20150175676
new patent

Fusion polypeptides capable of activating receptors


A fusion polypeptide comprising (a)x-m-(a′)y, wherein a and a′ are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins which activate the target receptor.
Regeneron Pharmaceuticals, Inc.
06/25/15
20150175670
new patent

Fusion proteins and combination vaccines comprising haemophilus influenzae protein e and pilin a


The present invention relates to compositions comprising haemophilus influenzae protein e and pilin a. More particularly, the present application relates to fusion proteins and immunogenic compositions comprising protein e and pila, vaccines comprising such immunogenic compositions and therapeutic uses of the same..
Glaxosmithkline Biologicals S.a.
06/25/15
20150175669
new patent

Novel peptide tag and uses thereof


There are provided peptide tags derived from bacteriophytochrome (bphp) that is photoreceptor protein of deinococcus <i/> radiodurans, an antibody capable of specifically recognizing the peptide tags, hybridoma cell lines capable of producing the antibody, and uses thereof. The novel peptide tag has advantages in that it has a short length and can remove a non-specific reaction of the conventional c-myc tag and flag tag.
University- Industry Cooperation Group Of Kyung Hee University
06/25/15
20150175604
new patent

Tricyclic heterocycles as bet protein inhibitors


The present invention relates to tricyclic heterocycles which are inhibitors of bet proteins such as brd2, brd3, brd4, and brd-t and are useful in the treatment of diseases such as cancer.. .
Incyte Corporation
06/25/15
20150174295
new patent

Porous orthopedic materials coated with demineralized bone matrix


A biomaterial including a porous biocompatible structure having interconnected pores, wherein the pores have interior walls and are interconnected by passageways, the interior walls and passageways being coated with an osteoinductive aqueous demineralized bone extract solution, the aqueous demineralized bone extract solution including growth factors, proteins, a demineralized bone matrix and at least one of a weak acid and a guanidine hydrochloride, wherein the demineralized bone matrix is present per 100 g of the solution in an amount of from about 2 g to about 10 g.. .
Biomet Manufacturing, Llc
06/25/15
20150174293
new patent

Biologic treatment system and method


A delivery system is provided that is adapted to treat various urological pelvic disorders, such as prolapse, incontinence, and the like. The delivery system can include at least one biologic loaded or otherwise provided with a bioactive agent, the biologic can comprise any drugs, hormones or steroids, stem cells, growth factors, proteins, and/or other bioactive agents to promote cell or tissue growth for the treatment and strengthening of organ walls or tissue.
Ams Research Corporation
06/25/15
20150174265
new patent

Reversible masking of pore-forming proteins for macromolecular delivery


The present invention features compositions and methods for enhancing endosomal escape of therapeutic agents in the cytoplasm of a cell to thereby provide more effective therapy. The endocytic pathway is the major uptake mechanism of cells, and biological agents such as proteins, dna, and sirna become entrapped in endosomes and subsequently degraded by lysosomal enzymes.
Massachusetts Institute Of Technology
06/25/15
20150174244
new patent

Optically-controlled cns dysfunction


Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive opsin proteins causes anxiety in the animal. Also provided herein are methods for alleviating and inducing anxiety in an animal as well as methods for screening for a compound that alleviates anxiety in an animal..
The Board Of Trustees Of The Leland Stanford Junior University
06/25/15
20150174237
new patent

Multimeric fusion protein vaccine and immunotherapeutic


The present disclosure provides fusion proteins that incorporate unique mechanisms for multimerizmg antigens to enhance their immunogenicity. The fusion proteins comprise at least two antigens, or other vaccine related proteins, separated by a linker sequence and an oligomerization domain.
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.
06/25/15
20150174231
new patent

Combination neisserial compositions


Compositions comprising a first biological molecule from a neisseria bacterium and a second biological molecule from a neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids.
Novartis Ag
06/25/15
20150174230
new patent

Chimeric protein vaccine against pneumonia caused by streptococcus pneumoniae


A vaccine based on the chimeric protein consisting of immunogenic epitopes of conservative streptococcus pneumoniae proteins: pspa, spr1895, and psaa, as well as flagellin components (flic1, flic2) functioning as safe adjuvant, the proteins or the peptides homologs to those to not less than 60% of their amino acid sequence, connected via flexible links.. .
Epitope Limited
06/25/15
20150174226
new patent

Ompa and asp14 in vaccine compositions and as diagnostic targets


Anaplasma phagocytophilum surface proteins asp14 and ompa and homologous genes from anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections caused by tick-born bacteria of the anaplasmatacaea family. Asp14 and/or ompa proteins or peptide fragments may be used in combination with other anaplasmatacaea surface proteins to elicit an immune response.
Virginia Commonwealth University
06/25/15
20150174208
new patent

Cosmetic and pharmaceutical composition with modified olygopeptides in form of supramolecular assembly


The invention is a cosmetic and pharmaceutical liposomal composition which comprises a mixture of carboxylated oligopeptides derived from natural polypeptides; insulin; hyaluronidase and collagenase by their enzymatic hydrolysis; followed by a carboxylation of the free amino groups of lysine, histidine, and additional hydrolysis of terminal amino groups in the oligopeptides. Natural polypeptides may be hydrolyzed with a proteolytic enzyme to form a mixture of oligopeptides and succinylated them.
06/25/15
20150174198
new patent

Gene transfer into airway epithelial stem cell by using lentiviral vector pseudotyped with rna virus or dna virus spike protein


The present inventors successfully introduced genes into stem cells of airway epithelial tissues using simian immunodeficiency virus vectors pseudotyped with f and hn, which are envelope glycoproteins of sendai virus. Gene transfer into airway epithelial tissue stem cells using a vector of the present invention is useful for gene therapy of genetic respiratory diseases such as cystic fibrosis.
Dnavec Corporation
06/25/15
20150173332
new patent

Human lambda light chain mice


Genetically modified mice are provided that express human λ variable (hvλ) sequences, including mice that express hvλ sequences from an endogenous mouse λ light chain locus, mice that express hvλ sequences from an endogenous mouse κ light chain locus, and mice that express hvλ sequences from a transgene or an episome wherein the hvλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins.
Regeneron Pharmaceuticals, Inc.
06/25/15
20150173331
new patent

Human lambda light chain mice


Genetically modified mice are provided that express human λ variable (hvλ) sequences, including mice that express hvλ sequences from an endogenous mouse λ light chain locus, mice that express hvλ sequences from an endogenous mouse κ light chain locus, and mice that express hvλ sequences from a transgene or an episome wherein the hvλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins.
Regeneron Pharmaceuticals, Inc.
06/18/15
20150168428

Compositions and methods for assessing cardiovascular disease


Some aspects of this disclosure relate to the characterization of lipoproteins (e.g., vldl, ldl, and/or hdl) based on their content of lipoprotein-associated proteins (e.g., apolipoproteins) for the determination of cardiovascular disease risk. Some aspects of this disclosure relate to methods for the diagnosis, early detection, risk estimation and monitoring of the course of diseases, in which one or more lipoprotein-associated protein is detected in a lipoprotein.
President And Fellows Of Harvard College
06/18/15
20150168427

Quantification of lipoproteins


Some aspects of this disclosure provide methods and reagents for the detection of apolipoproteins in a sample, for example, a sample obtained from a human subject. Some aspects of this disclosure provide protocols and reagents for the quantification of lipoproteins and lipoprotein particle populations comprising specific combinations of non-integral apolipoproteins and integral apolipoproteins, which is useful, inter alia, for the detection of diseases such as cardiovascular disease as well as an assessment of the risk of an individual to develop a disease..
President And Fellows Of Harvard College A Non-profit Corporation
06/18/15
20150168425

Method and agents to quantify proteins from tissues


As described herein, a robust generalizable method to accurately and sensitively quantitate proteins in tissues and fluids from human patients in a direct manner, not reliant on antibody reagents has been developed. This provides new and robust methods that are useful as biochemical outcome measures in human clinical trials.
Agada Biosciences, Llc
06/18/15
20150168417

Universal antigen retrieval compounds and methods of use


Provided herein are methods, compounds, mixtures and formulations of antigen retrieval agent useful in retrieving antigens and improving the detection of amino acids, peptides and proteins or epitopes thereon in a tissue fixed with aldehyde-based cross-linking agents. Contacting the fixed tissue with a solution of the aldehyde scavenging agent causes reactivity with the aldehyde moieties to retrieve antigens and improve detection of the amino acids, peptides and proteins or epitopes.
University Of Houston System
06/18/15
20150168402

Novel immunogenic proteins of leptospira


The invention provides novel immunogenic proteins liga and ligb from leptospira for use in the development of effective vaccines and antibodies, as well as improved diagnostic methods and kits.. .
Cornell University
06/18/15
20150168382

Methods and reagents for evaluating the binding of mammalian sperm


The present invention provides a new apparatus/system for determining fertility of mammalian sperm based on a specific sperm-binding test that mimics sperm binding to an egg. The inventive apparatus/system comprises surface-modified beads with a compound or conjugates containing a carbohydrate sequence associated with the mammalian zona-pellucida (zp) glycoproteins..
The Curators Of The University Of Missouri
06/18/15
20150168284

Capillary viscometer and multiscale pressure differential measuring device


The present subject matter provides a capillary viscometer for use in measuring concentration and shear dependence of the viscosity of macromolecular solutions. In one embodiment the device can automatically make serial dilutions of a single initial sample and record viscosity measurements across wide concentration ranges without changing samples.
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services
06/18/15
20150167019

Methods and products for transfecting cells


The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using rna are disclosed.
Factor Bioscience Inc.
06/18/15
20150167016

Plants tolerant to hppd inhibitor herbicides


The present invention relates to nucleic acid sequences encoding a hydroxyphenylpyruvate dioxygenase (ec 1.13.11.27, abbreviated herein as hppd) obtained from euryarchaeota belonging to the family picrophilaceae, as well as the proteins encoded thereby, and to a chimeric gene which comprises such nucleic acid sequence, and to the use of such nucleic acid sequences, proteins or chimeric genes for obtaining plants which are tolerant to hppd inhibitor herbicides.. .
Bayer Cropscience Ag
06/18/15
20150166985

Methods for correcting von willebrand factor point mutations


Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a nucleic acid encoding a mutant von willebrand factor protein to correct a point mutation associated with a disease or disorder, e.g., with von willebrand disease. The methods provided are useful for correcting a vwf point mutation within the genome of a cell or subject, e.g., within the human genome.
President And Fellows Of Harvard College
06/18/15
20150166984

Methods for correcting alpha-antitrypsin point mutations


Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a nucleic acid encoding a mutant α-antitrypsin protein to correct a point mutation associated with a disease or disorder, e.g., with chronic obstructive pulmonary disease (copd) disease. The methods provided are useful for correcting an α-antitrypsin point mutation within the genome of a cell or subject, e.g., within the human genome.
President And Fellows Of Harvard College
06/18/15
20150166983

Methods for correcting presenilin point mutations


Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a nucleic acid encoding a mutant presenilin1 protein to correct a point mutation associated with a disease or disorder, e.g., with familial alzheimer's disease. The methods provided are useful for correcting a psen1 point mutation within the genome of a cell or subject, e.g., within the human genome.
President And Fellows Of Harvard College
06/18/15
20150166982

Methods for correcting pi3k point mutations


Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a nucleic acid encoding a mutant pi3kca protein to correct a point mutation associated with a disease or disorder, e.g., with a neoplastic disorder. The methods provided are useful for correcting a pi3kca point mutation within the genome of a cell or subject, e.g., within the human genome.
President And Fellows Of Harvard College
06/18/15
20150166981

Methods for nucleic acid editing


Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of cas9 and nucleic acid editing enzymes or enzyme domains, e.g., deaminase domains, are provided.
President And Fellows Of Harvard College
06/18/15
20150166980

Fusions of cas9 domains and nucleic acid-editing domains


Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of cas9 and nucleic acid editing enzymes or enzyme domains, e.g., deaminase domains, are provided.
President And Fellows Of Harvard College
06/18/15
20150166974

Recombinant elastase proteins and methods of manufacturing and use thereof


The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins.
Proteon Therapeutics, Inc.
06/18/15
20150166678

Compositions and methods comprising binding proteins for adalimumab


Compositions and methods comprising proteins that bind specifically to adalimumab are disclosed herein. Adalimumab is a monoclonal antibody specific for the cytokine tnf-α and was developed to treat tnf-α mediated inflammatory diseases.
Abbvie Biotechnology Ltd
06/18/15
20150166671

Tiki inhibitors


Modulators of wnt activity, e.g., wnt inhibitors, that act on tiki proteins and inhibit tiki-mediated cleavage of wnt proteins, as well as methods of identifying such modulators and methods of use thereof.. .
Children's Medical Center Corporation
06/18/15
20150166634

Soluble tnf receptors and their use in treatment of disease


The present invention relates to tumor necrosis factor (tnf) antagonists and corresponding nucleic acids derived from tumor necrosis factor receptors (tnfrs) and their use in the treatment of inflammatory diseases. These proteins are soluble secreted decoy receptors that bind to tnf and prevent tnf from signaling to cells.
Roche Innovation Center Copenhagen A/s
06/18/15
20150166630

Btnl3 proteins, nucleic acids, and antibodies and uses thereof


The invention provides novel btnl3 proteins, including multimers, fragments, fusion proteins, and variants. In addition, antibodies that can bind to btnl3 proteins and nucleic acids encoding btnl3 proteins are provided.
Amgen Inc.
06/18/15
20150166628

Selective cartilage therapy


The present invention relates to compositions, methods and kits for delivery of an igf-1 protein or a functional fragment or variant, derivative thereof to cells or tissues that express proteoglycans. More specifically, the present invention relates to fusion proteins comprising a heparin binding protein (hb) comprising seq id no: 1 or seq id no: 2.
Ipsen Bioscience, Inc.
06/18/15
20150166622

Fusion proteins for treating metabolic disorders


The invention relates to the identification of fusion proteins comprising polypeptide and protein variants of fibroblast growth factor 21 (fgf21) with improved pharmaceutical properties. Also disclosed are methods for treating fgf21-associated disorders, including metabolic conditions..
06/18/15
20150166618

Methods and compositions for treating hemophilia


Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins involved in clotting into the genome of a cell for treating conditions including hemophilias.. .
Sangamo Biosciences, Inc.
06/18/15
20150166616

Modified polynucleotides for the production of cosmetic proteins and peptides


The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of cosmetic polynucleotides, cosmetic primary transcripts and cosmetic mmrna molecules.. .
Moderna Therapeutics, Inc.
06/18/15
20150166615

Method and uses for bombyx mori silk fibroin heavy chain mutation sequence and mutant


Provided is a method for bombyx mori silk fibroin heavy chain mutation including causing the mrna of a coded zinc-finger nucleases sequence to act upon a target point such as positions 1325-1362 of bombyx mori silk fibroin heavy chain gene as expressed in seq id no:1 so as to obtain a series of bombyx mori silk fibroin heavy chain mutated genes. Also provided is a mutation sequence prepared according to the method.
Southwest University
06/18/15
20150166613

Fusion proteins and combination vaccines comprising haemophilus influenzae protein e and pilin a


The present invention relates to compositions comprising haemophilus influenzae protein e and pilin a. More particularly, the present application relates to fusion proteins and immunogenic compositions comprising protein e and pila, vaccines comprising such immunogenic compositions and therapeutic uses of the same..
Glaxosmithkline Biologicals S.a.
06/18/15
20150166609

Fusion expression of g-protein coupled receptor


The present invention relates to fusion proteins for the expression of g-protein coupled receptor proteins (gpcr) with the fusion partners, as inserted fragments, from mammalian cells. The fusion partners are from a fragment of apj protein (“the apj protein fragment”) or a fragment with homology of more than 90% similarity to the apj protein fragment; or a fragment of rgs16 protein (the “rgs16 protein fragment”) or a fragment with homology of more than 90% similarity to the rgs16 protein fragment; or the fragment of dnj protein (the “dnj protein fragment”) or a fragment with homology of more than 90% similarity to dnj protein fragment.
Viva Biotech (shanghai) Ltd.
06/18/15
20150166472

Novel sigma receptor ligands and methods of modulating cellular protein homeostasis using same


The present invention includes compounds useful in preventing, treating or ameliorating sigma-related disorders or diseases. The compounds of the invention can modulate cellular protein homeostasis, which includes: translation initiation, folding, processing, transport, and degradation (including ubiquitin selective autophagy) of proteins.
Drexel University


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