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Proteins

Proteins-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Protein biomarkers and therapeutic targets for renal disorders
Case Western Reserve University
April 19, 2018 - N°20180106817

The present invention relates to a method of diagnosing a renal disorder. The method includes the steps of: (1) obtaining a biological sample from a subject; and (2) determining, in the biological sample, a level of one or more proteins whose abundance in urine change due to the renal disorder, wherein an increase or decrease in the level of one or more ...
Single chain proteins with c-terminal modifications
Novartis Ag
April 19, 2018 - N°20180106790

The invention pertains to an isolated vh single domain antibody comprising a c-terminal modification, where the c-terminal modification comprises a deletion of at least one amino acid residue that eliminates the interaction of a pre-existing antibody with the single domain antibody without interfering with the binding of the single domain antibody with its target.
Apparatus, systems, and methods for capillary electrophoresis
Proteinsimple
April 19, 2018 - N°20180106758

An apparatus includes a body portion that defines a reservoir and a set of substantially flexible capillaries. The set of substantially flexible capillaries are fixedly coupled to the body portion and in fluid communication with the reservoir. A connector is configured to be coupled to the body portion to be in fluid communication with the reservoir and the set of ...
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Compositions and methods for making selenocysteine containing polypeptides
Yale University
April 19, 2018 - N°20180105854

Non-naturally occurring trnasec and methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally occurring trnasec can be used for recombinant manufacture of selenocysteine containing polypeptides encoded by mrna without the requirement of an secis element. In some embodiments, selenocysteine containing polypeptides are manufactured by co-expressing a non-naturally occurring ...
L-ornithine production in eukaryotic cells
Biopetrolia Ab
April 19, 2018 - N°20180105850

The present invention relates to the provision of genetically modified microbial cells, such as yeast cells with an improved ability for producing l-ornithine and its derivatives. Overproduction of l-ornithine is obtained in the first place by the down-regulation or attenuation of specially selected genes, wherein said genes encode enzymes involved in the l-ornithine consumption and/or degradation pathways. Further l-ornithine ...
Synthetic repression of gene expression in plants
Colorado State University Research Foundation
April 19, 2018 - N°20180105825

The present disclosure provides synthetic repressor constructs and the proteins encoded therein, as well as synthetic repressible promoter constructs for use in combination with the synthetic repressor constructs/synthetic repressors disclosed herein. Various combinations of synthetic repressor constructs and synthetic repressible promoter constructs are also provided in synthetic genetic circuits for modifying expression of a protein of interest in a ...
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Proteins Patent Applications
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  • 271+ full patent PDF documents of Proteins-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Novel methods for recovery of leaf proteins
University Of Maryland, College Park
April 19, 2018 - N°20180105804

A novel method for processing soluble plant leaf proteins is described. While leaf proteins are considered potentially the most abundant source of protein in nature, the lack of efficient processing techniques for leaf proteins has limited their commercial use. The method described in this patent provides a means of extracting and purifying leaf proteins from plants which is suitable for ...
Multi-stage purification method and apparatus of extracellular vesicles using aqueous solution two-phase system
Postech Academy-industry Foundation
April 19, 2018 - N°20180105778

This disclosure relates to a multi-stage method and apparatus for purifying extracellular vesicles using an aqueous two-phase system, in which extracellular vesicles mixed and contaminated with proteins can be isolated and purified in a large amount at high purity within a short time through a multi-stage purification process using an aqueous two-phase system, thereby removing 95% or more of proteins and ...
Homogeneous antibody populations
Amgen Inc.
April 19, 2018 - N°20180105589

The present invention is generally directed to methods of producing an increase in the enrichment and/or recovery of preferred forms of monoclonal antibodies. More particularly, the invention relates to methods for eliminating disulfide heterogeneity in the hinge region of recombinant igg2 antibody proteins.
Binding molecules targeting pathogens
Apo-t B.v.
April 19, 2018 - N°20180105587

A first aspect of the disclosure relates to the field of binding molecules targeted at pathogens. The disclosure further relates to proteinaceous binding molecules targeting cells displaying pathogen-associated molecular patterns, in particular targeting cell surface molecules associated with or derived from pathogens, more in particular cell surface proteins displaying peptides from intracellular (pathogen associated) proteins.
Antibody directed against immunoglobulin-binding proteins of s. aureus
Arsanis Biosciences Gmbh
April 19, 2018 - N°20180105584

A monoclonal antibody that counteracts staphylococcus aureus by specifically binding to wild-type immunoglobulin-binding proteins (igbp) of s. Aureus comprising a cross-specific cdr binding site recognizing at least three of the igbp domains selected from the group consisting of protein a (spa) domains and immunoglobulin-binding protein (sbi) domains spa-a, spa-b, spa-c, spa-d, spa-e, sbi-i, and sbi-ii, wherein the antibody has an ...
Method of purifying albumin-fusion proteins
Medimmune, Llc
April 19, 2018 - N°20180105575

The present invention relates to a method of purifying albumin-fusion proteins to reduce the level of oxidation of susceptible amino acid residues. The method comprises an affinity matrix chromatography step and an anion exchange chromatography step. The purified albumin-fusion proteins have low levels of oxidation and retain their enhanced half-life in vivo and its bioactivity. In some embodiments, the albumin-fusion ...
Myelin oligodendrocyte glycoprotein, myelin basic protein, and proteolipid protein compositions and methods of use
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services
April 19, 2018 - N°20180105566

Disclosed is a protein comprising no more than three human autoantigenic proteins, wherein a first human autoantigenic protein comprises a truncated myelin oligodendrocyte glycoprotein (mog) amino acid sequence, a second human autoantigenic protein comprises a myelin basic protein (mbp) amino acid sequence, and a third human autoantigenic protein comprises a truncated proteolipid protein (plp) amino acid sequence. Also disclosed are ...
Proteins Patent Pack
Download 271+ patent application PDFs
Proteins Patent Applications
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For professional research & prior art discovery
inventor
  • 271+ full patent PDF documents of Proteins-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Aav vectors with high transduction efficiency and uses thereof for gene therapy
University Of Florida Research Foundation, Inc.
April 19, 2018 - N°20180105559

The present invention provides aav capsid proteins comprising modification of one or a combination of the surface-exposed lysine, serine, threonine and/or tyrosine residues in the vp3 region. Also provided are raav virions comprising the aav capsid proteins of the present invention, as well as nucleic acid molecules and raav vectors encoding the aav capsid proteins of the present invention. ...
Polypeptides, peptides, and proteins functionalized by alkylation of thioether groups via ring-opening reactions
The Regents Of The University Of California
April 19, 2018 - N°20180105553

Some embodiments of the invention involve methods for introduction of various functional groups onto polypeptides, peptides and proteins by alkylation of thioether (a. K. A. Sulfide) groups by ring opening reactions, creating new compositions of matter that may be useful for medical therapeutic or diagnostic applications. The thioether groups may either be present in the polypeptides, or may be added ...
Methods and compositions for inhibiting the interaction of menin with mll proteins
The Regents Of The University Of Michigan
April 19, 2018 - N°20180105531

The present disclosure provides compositions and methods of use to inhibit the interaction of menin with mll1, mll2 and mll-fusion oncoproteins. The compositions and methods of use are useful for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of mll1, mll2, mll fusion proteins, and/or menin.
Cyclic vinylogous amides as bromodomain inhibitors
April 19, 2018 - N°20180105485

The compounds are useful for treating diseases that arise from inappropriate activity of proteins containing an acetyl-lysine. The compositions comprise a genus of cyclic vinylogous amides that are inhibitors of bromodomain.
Cartridges, kits, and methods for enhanced detection and quantification of analytes
Cue Inc.
April 19, 2018 - N°20180104682

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test ...
Porous orthopedic materials coated with demineralized bone matrix
Biomet Manufacturing, Llc
April 19, 2018 - N°20180104382

A biomaterial including a porous biocompatible structure having interconnected pores, wherein the pores have interior walls and are interconnected by passageways, the interior walls and passageways being coated with an osteoinductive aqueous demineralized bone extract solution, the aqueous demineralized bone extract solution including growth factors, proteins, a demineralized bone matrix and at least one of a weak acid and a ...
Dye molecule and dye preparations, in particular for use in surgical methods of ophthalmic surgery ...
Al.chi.mi.a. S.r.l.
April 19, 2018 - N°20180104361

A dye molecule having the structure (i): where r1 is an so3− group bound to a hydrogen h atom or to another atom or to an ammonium nh4 group or to a lysine salt or to an arginine salt or to a different monovalent cation, and r2 is an so3− group, in particular for making dye preparations for ...
Recombinant virus replicon systems and uses thereof
Synthetic Genomics, Inc.
April 19, 2018 - N°20180104359

The present disclosure generally relates to viral-based expression systems suitable for the production of molecules of interest. The disclosure relates to nucleic acid constructs, such as expression vectors, containing a modified replicon rna which includes a modified 5′-unstranslated region (5′-utr) and, optionally, at least some of its original viral sequence encoding structural proteins having been deleted. Also disclosed ...
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