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Proteins patents

      

This page is updated frequently with new Proteins-related patent applications.




 Stable proteins and methods for designing same patent thumbnailStable proteins and methods for designing same
A method for designing and selecting a protein having a stabilized structure compared to a corresponding wild type protein, and proteins having at least six amino acid substitutions with respect to a corresponding wild type protein, designed for improved thermal stability, improved specific activity and/or improved expression levels, are provided herein.. .
Yeda Research And Development Co. Ltd.


 Diagnosis of chronic kidney disease by quantitative analysis of post-translational modifications of plasma proteins patent thumbnailDiagnosis of chronic kidney disease by quantitative analysis of post-translational modifications of plasma proteins
The present invention relates to methods for diagnosing and/or monitoring the onset or progression of chronic kidney disease (ckd) in a patient by the analysis of post-translational modification of plasma proteins. The present invention provides improved means for diagnosing chronic kidney disease (ckd), and especially for the early recognition of ckd..
Excorlab Gmbh


 Quantifying fr-alpha and gart proteins for optimal cancer therapy patent thumbnailQuantifying fr-alpha and gart proteins for optimal cancer therapy
Improved methods are provided for treating cancer patients, particularly patients suffering from lung cancer. Methods are provided for identifying whether a lung tumor will be responsive to treatment with a therapeutic regimen that includes pemetrexed and optionally includes cisplatin.
Expression Pathology, Inc.


 Stain-free protein quantification and normalization patent thumbnailStain-free protein quantification and normalization
Disclosed herein are methods of protein quantification and normalization using haloalkylated tryptophan fluorescence. Complex protein samples, i.e., samples that each contain 1,000 or more distinct proteins, from diverse sources that do not have common protein profiles are treated with a halo-substituted organic compound (i.e.
Bio-rad Laboratories, Inc.


 Methods and compositions for single chain variable region enox2 antibodies for cancer detection and diagnosis patent thumbnailMethods and compositions for single chain variable region enox2 antibodies for cancer detection and diagnosis
Cancers of different cellular or tissue origins express different enox2 cancer isoforms or combinations of isoforms and shed these proteins into the circulation. Herein are disclosed methods both for cancer detection and diagnosis of particular origin, based on the patterns and molecular weights of the isoforms which allow the identification of the cell type and or tissue of origin of the neoplasm.
Mor-nuco Enterprises, Inc.


 Methods for single chain variable region enox2 antibodies for cancer detection and diagnosis patent thumbnailMethods for single chain variable region enox2 antibodies for cancer detection and diagnosis
Cancers of different cellular or tissue origins express different enox2 cancer isoforms or combinations of isoforms and shed these proteins into the circulation. Herein are disclosed methods both for cancer detection and diagnosis of particular origin, based on the patterns and molecular weights of the isoforms which allow the identification of the cell type and or tissue of origin of the neoplasm.
Mor-nuco Enterprises, Inc.


 Isolation and detection of cancer cells patent thumbnailIsolation and detection of cancer cells
Provided are methods of using polycarbonate filters to isolate and detect cancer cells in a biological fluid, particularly biological fluids, such as urine, that contain very low concentrations of cancer cells. The characterization of the isolated cells for the presence or absence of cancer specific proteins is useful for cancer diagnosis and prognosis.
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.


 Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof patent thumbnailGenetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with rheumatoid arthritis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
Celera Corporation


 Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof patent thumbnailGenetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
Bristol-myers Squibb Company


 Peripheral neuropathy diagnosis patent thumbnailPeripheral neuropathy diagnosis
Genes whose expression is correlated with the presence of cidp or vasculitic neuropathy are disclosed. Probes and sets of nucleic acids and proteins specific for these genes are described, as are molecular and immunological methods for aiding in the diagnosis of these disease conditions in a subject..

Affinity tag nucleic acid and protein compositions, and processes for using same

The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides. Compositions include nucleic acid compositions and protein compositions with affinity binding pairs, including metal binding peptides and immobilized metals, or peptide affinity groups..
Enzo Biochem, Inc.

Compositions and methods for making selenocysteine containing polypeptides

Non-naturally occurring trnasec and methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally occurring trnasec can be used for recombinant manufacture of selenocysteine containing polypeptides encoded by mrna without the requirement of an secis element.
Yale University

Multi functional toxins

Pesticidal proteins are provided that combine two or more modes of action into a single molecule. These pesticidal proteins therefor exhibit greater efficacy and/or durability of resistance, for the purposes of pest control, and can be utilized for pest control by provision in the diet of a pest organism, or by topical application to crop plants and/or pests.
Monsanto Technology Llc

Recombinant host cell engineered to overexpress helper proteins

The present invention is in the field of recombinant biotechnology, in particular in the field of protein expression. The invention generally relates to a method of expressing a protein of interest (poi) from a host cell.
Lonza Ltd.

Two plasmid mammalian expression system

Reverse engineering has offered new ways of studying the pathology of rna viral infections, new more efficient devices of synthesizing recombinant viruses and developing vaccines and also demonstrated the versatility and efficiency of rna dependent rna polymerase rdrp system as an expression system. However, the currently used methods require a repertoire of complex, difficult-to-use tools.

Fermentation of fruit juices

A method of introducing yeast into a fruit juice such as grape must to be fermented is disclosed. The method comprises feeding dry yeast into a flowing stream of the fruit juice and delivering the flowing stream of fruit juice with the yeast in it to a mixer (10).
Rymco International Ag

Fn14 binding proteins and uses thereof

The present disclosure provides proteins comprising antibody antigen binding domains that bind to fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia..
La Trobe University

Multimeric fc proteins

The invention relates to multimeric proteins which bind to human fc receptors. The invention also relates to therapeutic compositions comprising the proteins, and their use in the treatment of immune and other disorders..
Ucb Biopharma Sprl

Novel peptides and combination of peptides for use in immunotherapy against esophageal cancer and other cancers

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer.
Immatics Biotechnologies Gmbh

Murine anti-ny-eso-1 t cell receptors

The invention provides an isolated or purified t cell receptor (tcr) having antigenic specificity for ny-eso-1. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv

Chimeric fibroblast growth factor 21 proteins and methods of use

The present invention relates to a chimeric protein that includes an n-terminus coupled to a c-terminus, where the n-terminus includes a portion of a paracrine fibroblast growth factor (“fgf”) and the c-terminus includes a c-terminal portion of an fgf21 molecule. The portion of the paracrine fgf is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification.
New York University

Fusion proteins and combination vaccines comprising haemophilus influenzae protein e and pilin a

The present invention relates to compositions comprising haemophilus influenzae protein e and pilin a. More particularly, the present application relates to fusion proteins and immunogenic compositions comprising protein e and pila, vaccines comprising such immunogenic compositions and therapeutic uses of the same..
Glaxosmithkline Biologicals S.a.

Pcv2 orf2 protein variant and virus like particles composed thereof

Vaccination methods to control pcv2 infection with different pcv2 subtypes are disclosed. Specifically, a pcv2 subtype b (pcv2b) orf2 proteins or immunogenic compositions comprising a pcv2b orf2 protein are used in a method for the treatment or prevention of an infection with pcv2 of the same pcv2b and/or different subtype; the reduction, prevention or treatment of clinical signs caused by an infection with pcv2 of the same pcv2b or a different subtype; and/or the prevention or treatment of a disease caused by an infection with pcv2 of the same pcv2b and/or a different subtype.
Boehringer Ingelheim Vetmedica, Inc.

Fusion proteins for use as immunogenic enhancers for inducing antigen-specific t cell responses

A fusion protein for use as an immunogen enhancer for enhancing antigen-specific t cell responses is disclosed. The fusion protein comprises: (a) an antigen-presenting cell (apc)-binding domain or a cd91 receptor-binding domain; (b) a protein transduction domain; and (c) an antigen of a pathogen, wherein the apc-binding domain or the cd91 receptor-binding domain is located at the n-terminus of the fusion protein, and the antigen of the pathogen is located at the c-terminus of the protein transduction domain.
Thevax Genetics Vaccine Co., Ltd.

Viral vector for the targeted transfer of genes in the brain and spinal cord

The invention relates to novel peptides, polypeptides or proteins which bind specifically to brain cells and/or to the spinal cord. The peptides, polypeptides, or proteins can be components of a viral capsid and can be used to lead a recombinant viral vector selectively to the brain and/or spinal cord after systemic administration to a subject and to ensure tissue-specific expression of one or more transgenes there.
UniversitÄtsklinikum Hamburg-eppendorf

Saa-domain-specific antibodies and peptide antagonists and use thereof to treat inflammatory diseases

Isolated saa peptides, fusion proteins and compositions comprising such are provided as are domain-specific saa antibodies. Methods of treating sepsis and endotoxemia are also provided..
The Feinstein Institue For Medical Research

Heparin affinity tag and applications thereof

In one aspect, affinity tags for recombinant protein purification are described herein which, in some embodiments, can mitigate or overcome disadvantages of prior affinity tag systems. In some embodiments, for example, affinity tags described herein permit efficient elution of desired recombinant proteins with simplified solution systems, such as alkali metal salt solutions.
The Board Of Trustees Of The University Of Arkansas

Allenamide as an orthogonal handle for selective modification of cysteine in peptides and proteins

There is provided a compound of formula i, having the structure: wherein r1 to r5 have the meanings given in the description.. .
Nanyang Technological University

Biodegradable, thermally responsive injectable hydrogel for treatment of ischemic cardiomyopathy

Provided are novel biocompatible copolymers, compositions comprising the copolymers, and methods of using the copolymers. The copolymers are non-toxic and typically have an lcst below 37° c.
University Of Pittsburgh -of The Commonwealth System Of Higher Education

Modified polynucleotides for the production of nuclear proteins

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmrna molecules.. .
Modernatx, Inc.

Compositions and methods for the prevention and treatment of metabolic diseases

The present invention is a new method and composition that enhance bone repair, formation, maintenance and slowing of bone resorption. The present invention relates to methods and compositions that enhance collagen formation, tendon health and tendon injury healing, bone maintenance and bone injury healing, and the prevention and treatment of metabolic diseases.

Composition based on xyloglucan and proteins for the treatment of intestinal disorders

Disclosed are compositions comprising synergic combinations of xyloglucans and plant or animal proteins, which are useful in the treatment of intestinal disorders.. .
Novintethical Pharma Sa

Protein-based enteric coating for oral dosage forms

The use of chemically modified proteins as enteric or gastroresistant coatings for oral dosage forms containing an active ingredient is described. Typical enteric coatings are made from synthetic polymers and function by acting as a barrier to gastric medium penetration.
9286-3620 Quebec Inc.

Multifunctional personal care devices/apparatuses and compositions for hair or skin

Personal care devices (or apparatuses) are described to deliver/activate a bioactive compound/botanical compound/biologically active molecule (including a regulatory protein/growth factor) or a mixture of bioactive compounds/botanical compounds/biologically active molecules (including regulatory proteins/growth factors) for growth and protection of hair or rejuvenation and protection of skin, which utilizes nanoencapsulation/nanoemulsion and/or activation/photoactivation. Such devices (or apparatuses) utilize a light low intensity module/x-ray and nanooptical elements/three-dimensionally (3-d) printed micro/nanostructures..

Method for obtaining napin and cruciferin or a mixture thereof from rapeseed

Described is a method for obtaining a mixture of the rapeseed proteins napin and cruciferin, or the individual proteins, in pure form from rapeseed meal, wherein once a raw extract has been obtained using a suitable extraction medium the desired proteins are purified from the raw extract by several purification steps at defined ph levels.. .
Pilot Pflanzenöltechnologie Magdeburg E.v.

Control device for a motor vehicle and control method

The present invention relates to a new process for the synthesis of colesevelam, which is used in therapy in cases of hypercholesterolemia due to low density lipoproteins. Said process comprises the reaction, in a basic environment, of polyallylamine with: i) at least one alkylating agent of formula x—(ch2)9—ch3 and at least one alkylating agent of formula y—(ch2)6—n+ (ch3)3z−, wherein x and y are each independently a leaving group, and z is a halogen; and ii) at least one crosslinking agent.
Dav

Atypical hemolytic uremic syndrome (ahus) biomarker proteins

The disclosure provides biomarker proteins, a change in the concentration or activity level of which are associated with atypical hemolytic uremic syndrome (ahus) or clinically meaningful treatment of ahus with a complement inhibitor. Also provided are compositions and methods for interrogating the concentration and/or activity of one or more of the biomarker proteins in a biological fluid.
Alexion Pharmaceuticals, Inc.

Surrogates of post-translationally modified proteins and uses thereof

The present invention provides compounds that are surrogates of post-translationally modified proteins and uses thereof. Numerous diseases are associated with post-translationally modified proteins that are difficult to obtain in homogenous form and in quantities needed for immunization and use as convenient standards, calibrators, and/or reference compounds that facilitate the detection and analysis of endogenous post-translationally modified proteins.
President And Fellows Of Harvard College

Methods for diagnosis and prognosis of epithelial cancers

The present invention is based on the discovery that three proteins, cystatin b, chaperonin 10, and profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples.
The General Hospital Corporation D/b/a Massachusetts General Hospital

Electrochemical methods and devices for amending urine samples for immunosensor detection

The present invention is directed to methods and devices for amending undiluted and partially diluted urine samples in a manner suitable for performing immunoassays for target analytes, for example ngal. Generally, the urine sample is treated with reagents including at least one of buffer materials, water soluble proteins, urease, and other interferent mitigants.
Abbott Point Of Care Inc.

Genetic polymorphisms associated with psoriasis, methods of detection and uses thereof

The present invention is based on the discovery of genetic polymorphisms that are associated with psoriasis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, such as a haplotype, a diplotype, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
Celera Corporation

Genetic polymorphisms associated with coronary events and drug response, methods of detection and uses thereof

The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection..
Celera Corporation

Novel herbicide resistance genes

The subject invention provides novel plants that are not only resistant to 2,4-d and other phenoxy auxin herbicides, but also to aryloxyphenoxypropionate herbicides. Heretofore, there was no expectation or suggestion that a plant with both of these advantageous properties could be produced by the introduction of a single gene.
Dow Agrosciences Llc

Methods and compositions for the production of guide rna

Various aspects and embodiments of the present disclosure relate to methods and compositions that combine multiple mammalian rna regulatory strategies, including rna triple helix structures, introns, micrornas, and ribozymes with cas-based crispr transcription factors and ribonuclease-based rna processing in human cells. The methods and compositions of the present disclosure, in some embodiments, enable multiplexed production of proteins and multiple guide rnas from a single compact rna-polymerase-ii-expressed transcript for efficient modulation of synthetic constructs and endogenous human promoters..
Massachusetts Institute Of Techology

Method for cell culture

A method for stem or progenitor cell culture. More precisely, the invention relates to a method for cell culture using one or more iαi (inter-alpha trypsin inhibitor or inter-alpha inhibitor) protein(s) or part(s) thereof as a component in a cell culture media or a coating on a cell culture surface material.
Ge Healthcare Biosciences Ab

Gitr antigen binding proteins

Antigen binding proteins that activate gitr are provided. Nucleic acids encoding the antigen binding proteins and vectors and cells containing such nucleic acids are also provided.
Amgen Inc.

Multivalent and multispecific gitr-binding fusion proteins

This disclosure generally provides molecules that specifically engage glucocorticoid-induced tnfr-related protein (gitr), a member of the tnf receptor superfamily (tnfrsf). More specifically, the disclosure relates to multivalent and/or multispecific molecules that bind at least gitr..
Inhibrx Lp

Prolactin receptor binding proteins and uses thereof

The present invention encompasses prlr binding proteins. Specifically, the invention relates to antibodies that are chimeric, cdr grafted and humanized antibodies.
Abbvie Inc.

Methods for systematic control of protein stability

Methods and compositions to control the stability of proteins with special emphasis on antibodies and proteins with antibody-like structures, e.g., having an “immunoglobulin-like” fold, are described. Controlling the stability facilitates different applications for a protein with the same function, but different stability..
Uchicago Argonne Llc

Novel cell epitopes and combination of cell epitopes for use in the immunotherapy of myeloma and other cancers

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer, in particular myeloma.
Immatics Biotechnologies Gmbh

Natural and synthetic compounds for treating cancer and other diseases

This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder, prostatic, skin, bone, brain, leukemia, lung, colon, cns, melanoma, renal, cervical, esophageal, testicular, spleenic, kidney, lymphatic, pancreatic, stomach and thyroid cancers. This invention is an anti-adhesion therapy which uses the compound as a mediator or inhibitor of adhesion proteins and angiopoietins.
Pacific Arrow Limited

Synthesis of amphiphilic calixarene glycoside detergents and use of same for extracting and stabilizing native functional membrane proteins

Amphiphilic calixarene glycoside compounds, the preparation of such compounds, and the use of such compounds for selectively extracting, solubilizing and stabilizing membrane proteins.. .
Calixar





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This listing is a sample listing of patent applications related to Proteins for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Proteins with additional patents listed. Browse our RSS directory or Search for other possible listings.


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