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Proteins patents



      
           
This page is updated frequently with new Proteins-related patent applications. Subscribe to the Proteins RSS feed to automatically get the update: related Proteins RSS feeds. RSS updates for this page: Proteins RSS RSS


Method for producing hypoallergenic peanut products

Date/App# patent app List of recent Proteins-related patents
08/28/14
20140245497
 Drought tolerant plants and related constructs and methods involving genes encoding ferredoxin family proteins patent thumbnailnew patent Drought tolerant plants and related constructs and methods involving genes encoding ferredoxin family proteins
Isolated polynucleotides and polypeptides and recombinant dna constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant dna constructs, and methods utilizing these recombinant dna constructs. The recombinant dna construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a ferredoxin family protein..
08/28/14
20140243509
 Near infrared fluorogen and fluorescent activating proteins for in vivo imaging and live-cell biosensing patent thumbnailnew patent Near infrared fluorogen and fluorescent activating proteins for in vivo imaging and live-cell biosensing
Tissue slices and whole organisms offer substantial challenges to fluorescence imaging. Autofluorescence and absorption via intrinsic chromophores, such as flavins, melanin, and hemoglobins, confound and degrade output from all fluorescent tags.
08/28/14
20140243504
 Antibodies comprising chimeric constant domains patent thumbnailnew patent Antibodies comprising chimeric constant domains
Antibodies, antigen-binding proteins and fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric fc-containing antibodies, antigen-binding proteins and fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric fc-containing proteins are provided..
08/28/14
20140243431
 Flourescent in-situ detection of lipid particle apolipoproteins within primary electrophoretic matrix patent thumbnailnew patent Flourescent in-situ detection of lipid particle apolipoproteins within primary electrophoretic matrix
The present invention relates to, among other things, a gel electrophoresis system for detecting the level of specific apolipoproteins and/or lipoprotein particles present in intact lipid particles in a biological sample. The system includes a gel substrate to receive a biological sample, at least two lipoprotein-binding complexes.
08/28/14
20140243322
 Bivalent bromodomain ligands, and methods of using same patent thumbnailnew patent Bivalent bromodomain ligands, and methods of using same
Described herein are compounds capable of modulating one or more biomolecules substantially simultaneously, e.g., modulating two or more binding domains (e.g., bromodomains) on a protein or on different proteins.. .
08/28/14
20140243321
 Bioorthogonal monomers capable of dimerizing and targeting bromodomains, and methods of using same patent thumbnailnew patent Bioorthogonal monomers capable of dimerizing and targeting bromodomains, and methods of using same
Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g.
08/28/14
20140243286
 Bromodomain ligands capable of dimerizing in an aqueous solution, and methods of using same patent thumbnailnew patent Bromodomain ligands capable of dimerizing in an aqueous solution, and methods of using same
Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g.
08/28/14
20140243277
 Water soluble membrane proteins and methods for the preparation and use thereof patent thumbnailnew patent Water soluble membrane proteins and methods for the preparation and use thereof
The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.. .
08/28/14
20140243272
 Compound and method for treatment of alzheimer's disease patent thumbnailnew patent Compound and method for treatment of alzheimer's disease
An isolated protein selected from the group consisting of (i) proteins comprising an amino acid sequence having at least 70% identity to the c-terminal domain of lung surfactant protein c precursor (ctprosp-c, “ctc”) from a mammal; and (ii) proteins comprising an amino acid sequence having at least 70% identity to the brichos domain of ctprosp-c from a mammal, is disclosed for treatment of alzheimer's disease in a mammal, including man.. .
08/28/14
20140243266
 Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases patent thumbnailnew patent Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
The invention relates to variants and fusions of fibroblast growth factor 19 (fgf19), variants and fusions of fibroblast growth factor 21 (fgf21), fusions of fibroblast growth factor 19 (fgf19) and/or fibroblast growth factor 21 (fgf21), and variants or fusions of fibroblast growth factor 19 (fgf19) and/or fibroblast growth factor 21 (fgf21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as bile acid homeostasis modulating activity, and methods for and uses in treatment of bile acid and other disorders.. .
08/28/14
20140243265
new patent Antibodies to modified human igf-1/e peptides
High-specificity antibodies can distinguish between modified (e.g, higf-1/ea 3mut) and endogenous wild-type human igf-1 proteins. These antibodies have little or no cross-reactivity with higf-1 or higf-2.
08/28/14
20140243260
new patent Chimeric fibroblast growth factor 23 proteins and methods of use
The present invention relates to an isolated chimeric protein. The isolated chimeric protein includes an n-terminus coupled to a c-terminus, where the n-terminus includes an n-terminal portion from a fibroblast growth factor (“fgf”) 23 molecule and the c-terminus includes a c-terminal portion from an fgf19 molecule.
08/28/14
20140243259
new patent Glycoproteins having lipid mobilizing properties and therapeutic uses thereof
The invention provides compositions and methods for ameliorating symptoms associated with hyperglycemia by administering a zn-α2-glycoprotein or a functional fragment thereof, methods of decreasing plasma insulin levels, methods of increasing skeletal muscle mass, and methods of bringing about a weight reduction or reduction in obesity. Also provided are pharmaceutical compositions for use thereof..
08/28/14
20140243235
new patent Peripheral neuropathy diagnosis
Genes whose expression is correlated with the presence of cidp or vasculitic neuropathy are disclosed. Probes and sets of nucleic acids and proteins specific for these genes are described, as are molecular and immunological methods for aiding in the diagnosis of these disease conditions in a subject..
08/28/14
20140243234
new patent Nucleic acid compositions, methods and kits for rapid pairing of affinity agents
The present inventions relate to the selection and production of specific proteins or peptides with desired properties. The inventions relate to the agents and methods of identifying select peptides or proteins with specific binding properties or greater enzymatic performance from vast numbers of variants..
08/28/14
20140242695
new patent Protein-induced pluripotent cell technology and uses thereof
A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the qq-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and passaging the reprogrammed cells in a whole dish for generating homogeneous pips cells. Also provided are the pipcs cells formed using this method and uses thereof..
08/28/14
20140242692
new patent Mammalian genes involved in toxicity and infection
The present invention relates to cellular proteins that are involved in toxicity and infection or are otherwise associated with the life cycle of one or more pathogens.. .
08/28/14
20140242679
new patent Method for producing hypoallergenic peanut products
A peanut food product with reduced levels of allergenic proteins such as ala h1/h2/h3 is produced by initiating the germination process in raw peanuts, holding the peanuts in moist conditions to initiate germination and then treating with bromelain.. .
08/28/14
20140242676
new patent Artificial leaf-like microphotobioreactor and methods for making the same
Described herein are algae carbon capture systems and biomass production systems, and more specifically, algal based microphotobioreactors (μpbrs) comprising a biocompatible polymer (e.g., hydrogel) containing algae, inorganic carbon, light-frequency shifting agents (e.g., quantum dots and/or dyes of fluorescent proteins) and methods for making such μpbrs.. .
08/28/14
20140242606
new patent Probe for ifret and use thereof
The present invention relates to a probe for ifret and use thereof. Specifically, the present invention relates to a novel probe for ifret, a method for preparing the probe for ifret, a method for searching a target protein-specific binding site or a molecule having the binding site using the probe for ifret, and a method for imaging the target protein using the probe for ifret.
08/28/14
20140242602
new patent Uses of labeled hsp90 inhibitors
The disclosure provides evidence that the abundance of this particular “oncogenic hsp90” species, which is not dictated by hsp90 expression alone, predicts for sensitivity to hsp90 inhibition therapy, and thus is a biomarker for hsp90 therapy. The disclosure also provides evidence that identifying and measuring the abundance of this oncogenic hsp90 species in tumors predicts of response to hsp90 therapy.
08/28/14
20140242569
new patent Poultry performance
Methods for increasing breast muscle weight in poultry are disclosed herein. These methods can include delivery of compositions via in ovo administration.
08/28/14
20140242184
new patent Compositions for regenerating defective or absent myocardium
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function..
08/28/14
20140242183
new patent Compositions for regenerating defective or absent myocardium
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function..
08/28/14
20140242182
new patent Formulations that stabilize proteins
In one aspect, the disclosure provides formulations that stabilize proteins, wherein the formulations comprise a buffer. In some embodiments, the buffer comprises potassium mono-hydrogen-phosphate and potassium di-hydrogen-phosphate, or the buffer comprises sodium mono-hydrogen-phosphate and sodium di-hydrogen-phosphate.
08/28/14
20140242142
new patent Cell secreted proteins for the treatment of myocardial infarction
The present invention relates to the use of secreted proteins from mesenchymal stem cells and other cells for the treatment of myocardial infarction. In particular, the invention provides compositions and methods based on secreted proteins from mesenchymal stem cells and the genes encoding them..
08/28/14
20140242111
new patent Engineered bacteria for oral delivery of glucoregulatory proteins
Disclosed is an oral delivery system that overcomes major barriers encountered in the gastrointestinal tract, particularly rapid proteolytic degradation and low intestinal permeability. Provided is a method for oral delivery of an engineered microorganism to a mammal where the microorganism produces a macromolecule having a desired bioavailability outcome..
08/28/14
20140242106
new patent Staphylococcus aureus proteins and nucleic acids
The invention provides proteins from staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics..
08/28/14
20140242089
new patent Glycoproteins having lipid mobilising properties and therapeutic applications thereof
A biologically active lipid mobilising agent for use in therapy is disclosed which has the properties and characteristics of a zn-α2-glycoprotein, or of a fragment thereof having an apparent molecular mass mr greater than 6.0 kda as determined by gel exclusion chromatography. Methods of isolation and purification from biological material are also disclosed together with uses of the material for making up pharmaceutical compositions, especially pharmaceutical compositions useful for treating mammals to achieve weight reduction or for controlling obesity.
08/28/14
20140242086
new patent Polynucleotides encoding signal peptide-containing molecules
The invention provides human signal peptide-containing proteins (hspp) and polynucleotides which identify and encode hspp. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists.
08/28/14
20140242084
new patent Angiopoietin-like 4 and its use in modulating cell leakiness
Vascular disruption induced by interactions between tumor-secreted permeability factors and adhesive proteins on endothelial cells facilitates metastasis. The role of tumor secreted angiopoietin-like 4 (cangptl4) in vascular leakiness and metastasis is controversial due to the lack of understanding of how cangptl4 modulates vascular integrity.
08/28/14
20140242077
new patent Methods and compositions for modulating an immune response
Provided are multispecific binding proteins and methods for using these multispecific binding proteins to modulate the activation state of immune cells, such as t-cells (e.g., cytotoxic t-cells). Also provided are methods of modulating an immune response (e.g., cell killing by cytotoxic t-cells) in a subject (e.g., a human subject).
08/28/14
20140242065
new patent Compositions for regenerating defective or absent myocardium
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function..
08/28/14
20140242037
new patent Apc-mediated tolerance induction for therapy of multiple sclerosis
The invention relates to transgene expression constructs—particularly self inactivating lentiviral vectors—comprising a dendritic cell specific promoter controlling the expression of autoantigen proteins, namely myelin basic protein, proteolipid protein and myelin oligodendrocyte glycoprotein, for use in the therapy of multiple sclerosis.. .
08/28/14
20140242036
new patent Process for potentiating the production of lingzhi mushroom (ganoderma lucidum) substances and antifungal activity thereof
The instant invention refers to a novel process for potentiating the production of substances with antifungal activity obtained from ganoderma lucidum, using a technological device for the differential, qualitative and quantitative expression of proteins and other bioactive molecules, selected from the group consisting of polysaccharides, triterpenoids, fatty acids and ganoderic acids. The compositions containing said substances showed antifungal activity and mycelium growth and fungi ascospore germination inhibiting activity, amongst them mycosphaerella fijiensis, primary pathogenic agent causing black sigatoka disease in banana and plantain crop fields..
08/28/14
20140241956
new patent Liquid to liquid biological particle concentrator with disposable fluid path
Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream.
08/21/14
20140237689
Metabolic regulators
The present invention provides metabolic regulators, which are proteins (such as fusion proteins, truncated proteins or full-length proteins) that bind to specific metabolites and which can be used to control the availability of the metabolites in cells, particularly plant cells. Proteins of the invention include one or more metabolic regulator proteins, can be truncated or full length, can further comprise a transmembrane domain or lipoylation site or can further comprise a transit peptide.
08/21/14
20140237632
Rapidly maturing fluroscent proteins and methods for using the same
Nucleic acid compositions encoding rapidly maturing fluorescent proteins, as well as non-aggregating versions thereof (and mutants thereof) as well as the proteins encoding the same, are provided. The proteins of interest are proteins that are fluorescent, where this feature arises from the interaction of two or more residues of the protein.
08/21/14
20140237631
Neurovirulent strain of the west nile virus and uses thereof
Neuroinvasive and neurovirulent strain of the west nile virus, named is-98-st1, nucleic acid molecules derived from its genome, proteins and peptides encoded by said nucleic acid molecules, and uses thereof.. .
08/21/14
20140235836
Immunologic constructs and methods
The present invention relates to improved vaccines and the design and making of such vaccines that enhance immunogenicity of the vaccine and/or reduce reactogenicity to the vaccine when administered. In particular the vaccines and immunogenic compositions of the present invention relate to flagellin-antigen fusion proteins in which the spatial orientation of the flagellin to antigen and the charge distribution of the antigen is optimized to enhance immunogenicity and/or reduce reactogenicity and/or improve folding of the protein..
08/21/14
20140235831
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
08/21/14
20140235830
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
08/21/14
20140235700
Lentiviral vectors pseudotyped with mutant baev glycoproteins
The present invention concerns a pseudotyped viral vector particle for transferring biological material into cells, wherein said vector particle comprises at least:—a chimeric envelope glycoprotein which comprises or consists in a fusion of the transmembrane and extracellular domain of a baboon endogenous retrovirus (baev) envelope glycoprotein and the cytoplasmic tail domain of a murine leukemia virus (mlv) envelope glycoprotein; or—a modified baev envelope glycoprotein wherein the cytoplasmic tail domain is devoid of the fusion inhibitory r peptide.. .
08/21/14
20140235631
Efflux inhibitor compositions and methods of treatment using the same
The present invention relates to efflux inhibitor compositions and methods of using these agents for treating conditions where the activity of efflux transporter proteins (e.g., breast cancer resistance protein (bcrp) and p-glycoprotein (p-gp)) inhibit effective delivery of a therapeutic agent to a target tissue (e.g., brain, spinal cord, nerves, cerebrospinal fluid, testis, eyeballs, retina, inner ear, placenta, mammary gland, liver, biliary tract, kidney, intestines, lung, adrenal cortex, endometrium, hematopoietic cells, and/or stem cells).. .
08/21/14
20140235626
Pyridine derivatives and a pharmaceutical composition for inhibiting bace1 containing them
Or a pharmaceutically acceptable salt thereof which has an effect of inhibiting amyloid β production, especially an effect of inhibiting bace1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid β proteins.. .
08/21/14
20140235620
3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
The invention is directed to a compound of formula (i) or a pharmaceutically acceptable salt thereof, wherein r1-r6 are defined herein. The invention is also directed to compositions containing a compound of formula (i) and to the use of such compounds in the inhibition of mutant idh proteins having a neomorphic activity.
08/21/14
20140235605
Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment, particularly for reducing the risk of cardiovascular disease, especially coronary heart disease (such as myocardial infarction) and stroke. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents and kits for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents and kits for their detection..
08/21/14
20140235549
Stabilized polypeptides as regulators of rab gtpase function
The present invention provides inventive polypeptides comprising a c terminal rab binding domain (rabbd) of rab family interacting proteins (fips) stabilized by peptide stapling, and pharmaceutical compositions thereof. Also provided are methods for modulating rab function comprising contacting an inventive stapled polypeptide with a rab protein, and methods of treatment associated with modulation of rab activity.
08/21/14
20140235548
Compositions and methods for jamm protein inhibition
Compounds, pharmaceutical compositions, and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by jamm proteins are disclosed. The compounds and compositions inhibit the enzymatic activity of a jamm domain, including the jamm domain of the csn5 subunit of the cop9-signalsome (csn), the jamm domain of the rpn11/poh1/psmd14 subunit of the 26s proteasome, the jamm domain of amsh, the jamm domain of amsh-lp, the jamm domain of brcc36, among other jamm domains..
08/21/14
20140235534
Glycoproteins having lipid mobilizing properties and therapeutic uses thereof
The invention provides formulations and methods for ameliorating symptoms associated with metabolic disorders, such as cachexia, hypoglycemia, obesity, diabetes, and the like by administering zn-α2-glycoproteins or a functional fragment thereof, alone or in combination with additional agents, such as β adrenergin receptor agonists, β adrenergin receptor antagonists, and/or glycemic control agents.. .
08/21/14
20140235510
Microfluidic interface for highly parallel addressing of sensing arrays
Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface.
08/21/14
20140235507
Protein chips for high throughput screening of protein activity
The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneously the presence, amount, and/or function of proteins present in a protein sample or on one protein chip, or to assay the presence, relative specificity, and binding affinity of each probe in a mixture of probes for each of the proteins on the chip.
08/21/14
20140235494
Methods, kits and computer program products using hepatocellular carcinoma (hcc) biomarkers
Methods of determining the presence or risk of liver disease or other diseases in a subject include measuring a level of a saccharide selected from n-acetylneuraminic acid, n-acetylglucosamine, n-acetylgalactosamine, or a combination thereof on one or more glycosylated proteins and the total amount of alpha-fetoprotein in a biological sample from the subject. Glycosylated proteins include but are not limited to vascular endothelial growth factor, lymphatic vessel endothelial hyaluronan receptor, e-cadherin, alpha 1 acid glycoprotein, glypican-3, galectin-3, and any combination thereof.
08/21/14
20140235483
Parallel determination of competitive binding and target specificity of a binding compound library by high-throughput dna sequencing
The invention is directed to a method for analyzing the competitive binding and target (or ligand) specificity of large numbers of candidate binding compounds with respect to a predetermined reference compound. That is, the invention provides a method for essentially conducting a massively parallel elisa on each member of an entire library of candidate binding compounds at the same time.
08/21/14
20140235476
Multivalent binding protein compositions and methods for identifying variants of same
Provided are protein, nucleic acid, and cellular libraries of multivalent binding proteins (e.g., dvd-fab or dvd-ig molecules) and the use of these libraries for the screening of multivalent binding proteins using cell surface display technology (e.g., yeast display).. .
08/21/14
20140234979
Rapid protein labeling and analysis
The present invention provides methods and compositions for labeling, separating and analyzing proteins, particularly a specific protein of interest within a cell lysate or in a mixture of proteins. The proteins are labeled with an amine reactive or thiol reactive fluorescent dye, or an amine reactive fluorogenic reagent that becomes fluorescent upon reacting to amine groups located on the protein.
08/21/14
20140234975
Method for increasing the efficiency of double-strand-break induced mutagenesis
The present invention relates to a method for increasing double-strand-break induced mutagenesis at a genomic locus of interest in a cell, thereby giving new tools for genome engineering, including therapeutic applications and cell line engineering. More specifically, the present invention concerns the combined use of talen or meganucleases with trex2, especially under the form of single-chain proteins..
08/21/14
20140234970
Modulation of stem cells using zinc finger proteins
Methods and compositions for modifying stem cells using one or more zfps are disclosed. Such methods and compositions are useful for facilitating processes such as, for example, dedifferentiating cells, differentiating stem cells into the desired phenotype, propagating stem cells and/or facilitating cloning..
08/21/14
20140234961
Synthetic single chain variable domain (scfv) immunoglobulin fragment vehicle containing fusion proteins for targeted introduction of sirna
A fusion protein and process are provided by which double-stranded rna containing small interfering rna nucleotide sequences is introduced into specific cells and tissues. A cell surface receptor specific synthetic single chain variable domain (scfv) immunoglobulin fragment vehicle specific to a cell surface receptor of the cell and having a cell surface receptor specific binding site is provided.
08/21/14
20140234957
Engineered cellular pathways for programmed autoregulation of differentiation
The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type.
08/21/14
20140234948
Molecular motor
A molecular motor in which multiple concentric cylinders (or nested cones) rotate around a common longitudinal axis. Opposing complementary surfaces of the cylinders or cones are coated with complementary motor protein pairs (such as actin and myosin).
08/21/14
20140234942
Substrates and methods for collection, stabilization and elution of biomolecules
A solid substrate for the extraction, stabilization, and storage of proteins is provided. The substrate includes: a polysaccharide, such as melezitose under a substantially dry state.
08/21/14
20140234933
Egvii endoglucanase and nucleic acids encoding the same
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding egvii amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding egvii, recombinant egvii proteins and methods for producing the same..
08/21/14
20140234932
Bgl7 beta-glucosidase and nucleic acids encoding the same
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl7, and the corresponding bgl7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding bgl7, recombinant bgl7 proteins and methods for producing the same..
08/21/14
20140234931
Bgl6 beta-glucosidase and nucleic acids encoding the same
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl6, and the corresponding bgl6 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding bgl6, recombinant bgl6 proteins and methods for producing the same..
08/21/14
20140234908
Use of non-subtype b gag proteins for lentiviral packaging
The invention encompasses a lentiviral packaging vector comprising a non-subtype b gag-pol sequence, particularly a subtype d gag-pol sequence. The invention further encompasses methods for making and using these vectors.
08/21/14
20140234904
Method for harvesting photosynthetic unicells using genetically induced flotation
Methods for the harvesting of photosynthetic unicellular organisms are provided, including the formation and expression or overexpression of gas vesicles or vacuole proteins in photosynthetic unicellular organisms. Dna constructs as well as methods for integration of the dna constructs into the genomes of photosynthetic unicellular organisms for the formation and expression or overexpression of gas vesicles or vacuole expression proteins in unicellular organisms are also disclosed..
08/21/14
20140234903
Biosynthetic gene cluster for the production of peptide/protein analogues
A novel gene cluster encoding polypeptides involved in the generation of bio synthetically unique peptide-based compounds is described. In addition, new methods for biosynthetic engineering and production of modified peptides and proteins are disclosed.
08/21/14
20140234902
Methods for producing modified glycoproteins
Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar, if not substantially identical, to their human counterparts.
08/21/14
20140234885
Methods for optimizing domain stability of binding proteins
Provided are methods for measuring the inherent stability of intrachain disulphide-containing domains (e.g., antibody variable domains) and for optimizing the positioning of intrachain disulphide-containing domains within a protein (e.g., a multispecific binding protein, e.g., a dvd-ig). Also provided are methods of making multispecific binding proteins (e.g., dvd-ig molecules) comprising two or more antibody variable domains in which the antibody variable domains are optimally positioned within the multispecific binding proteins to enhance stability of the multispecific binding protein.
08/21/14
20140234872
Target of the phosphoinositide 3-kinase pathway
The present disclosure generally relates to tyrosine phosphorylation sites of an akt enhancer, and methods for the detection of the phosphorylated tyrosine residues. In particular, anti-phosphotyrosine antibodies and binding proteins find use in the compositions and methods of the present disclosure..
08/21/14
20140234862
Compositions and methods for quantitatively monitoring lipids
Provided herein are fluorescent lipid binding proteins (flbps). The flbps comprise a lipid binding domain linked to a fluorophore, whereby the fluorophore's fluorescence emission undergoes a spectral change upon lipid binding..
08/21/14
20140234854
Method for evaluation of presence of or risk of colon tumors
The disclosed methods are used to predict or assess colon tumor status in a patient. They can be used to determine nature of tumor, recurrence, or patient response to treatments.
08/21/14
20140234846
Recombinase polymerase amplification
This disclosure describes related novel methods for recombinase-polymerase amplification (rpa) of a target dna that exploit the properties of recombinase and related proteins, to invade double-stranded dna with single stranded homologous dna permitting sequence specific priming of dna polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes.
08/21/14
20140234837
Epigenetic marker for the identification of natural killer cells
The present invention relates to a method, in particular an in vitro method for identifying a subgroup of natural killer cells of a mammal, preferably cd3−, non t-lymphocyte derived nk cells, which often express the surface proteins cd56 and/or cd16, comprising analyzing the accessibility of the genomic dna for osbpl, such as osbpl5, to bisulfite conversion and/or the methylation status of at least one cpg position in the genes for osbpl, such as osbpl5, in particular in their upstream and/or downstream regulatory regions, the promoter, introns, exons and introns exon borders and other conserved regions of said genes, wherein an increase of the accessibility of the genomic dna and/or a demethylation in the sample as analyzed is indicative for said subgroup of nk cells. The analyses according to the invention can identify cd56+ cells and distinguish them from all other cells such as, for example, either cd56− and/or cd56 bright cells.
08/21/14
20140234509
Taste masking compositions and edible forms thereof for masking the taste of foods
Disclosed are edible compositions, for example, edible films and gummi confectioneries, that mask the taste of bitter tasting foods and/or foods that contain proteins such as meats and vegetables like broccoli, cabbage, spinach, etc. The edible compositions include a delivery vehicle, a protein masking agent constituting about 0.01% to about 25% dry weight thereof, and a bitter masking agent constituting about 0.1% to about 7% dry weight thereof.
08/21/14
20140234506
Methods and compositions for protein concentration
The present invention concerns concentrating dairy proteins. Methods of the invention include the production and use of negatively-charged ultrafiltration membranes to achieve high hydraulic permeability with low sieving coefficients..
08/21/14
20140234372
Novel vlps derived from cells that do not express a viral matrix or core protein
The present invention discloses novel influenza virus-like particles (vlps) that contain chimeric proteins or influenza membrane proteins. The chimeric proteins are derived from fragments of influenza membrane proteins fused to heterologous proteins.
08/21/14
20140234368
Hypo- and hyper-acetylated meningococcal capsular saccharides
Capsular saccharides derived from serogroups w135 and y of neisseria meningitidis have altered levels of o-acetylation at the 7 and 9 positions of their sialic acid residues, and can be used to make immunogenic compositions. Relative to unmodified native saccharides, derivatives of the invention are preferentially selected during conjugation to carrier proteins, and conjugates of the derivatives show improved immunogenicity compared to native polysaccharides..
08/21/14
20140234363
Polypeptides from non-typeable haemophilus influenzae
Polypeptides comprising non-typeable haemophilus influenzae (nthi) amino acid sequences. Over 2500 specific nthi proteins are disclosed.
08/21/14
20140234362
Defensin-antigen fusion proteins
The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (hiv) infection. In particular, the present invention provides a fusion protein comprising a defensin fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection..
08/21/14
20140234358
Newcastle disease virus vectored avian vaccines
The present invention encompasses engineered newcastle disease virus (ndv) vaccines or compositions. The vaccine or composition may be a recombinant vaccine.
08/21/14
20140234357
H5 proteins of h5n1 influenza virus for use as a medicament
The present invention is based on the surprising finding that h5 protein of clade 1 h5n1 induces, in particular by a single-shot vaccination, a cross-clade protective immune response to influenza viruses with h5n1 ha. In one aspect, the invention is thus directed to h5 protein of clade 1 h5n1 virus for use in a method of treating or preventing infections with h5n1 virus of a different clade, wherein the h5n1 virus of a different clade comprises a particular polynucleotide and/or h5 protein..
08/21/14
20140234338
Therapeutic agent for use in a method of treating psoriasis or atopic dermatitis
The present invention provides a therapeutic agent for psoriasis or atopic dermatitis, and comprises anti-staphylococcus aureus antibodies as the active ingredient. A therapeutic agent for psoriasis or atopic dermatitis is specifically provided.
08/21/14
20140234316
Vaccibodies targeted to cross-presenting dendritic cells
The present invention relates to recombinant fusion proteins targeted to dendritic cells and uses thereof. In particular, the present invention relates to fusion proteins comprising an antibody component and a targeting components, and uses of such fusion proteins to trigger immune responses..
08/21/14
20140234309
Antibody-mediated transduction of heat shock proteins into living cells
The invention provides for a fusion protein comprising a 3e10 fv joined to a hsp-70, hsp-27, hsp-90 or grp-78or portion thereof, and optionally, the 3e10 fv comprising an amino acid sequence agih at its amino terminus.. .
08/21/14
20140234291
Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with rheumatoid arthritis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection..
08/21/14
20140234290
Modified factor x polypeptides and uses thereof
Modified therapeutic proteins are provided. In particular modified factor x polypeptides, which includes the factor x zymogen, factor xa and other forms of factor x, and uses thereof are provided..
08/21/14
20140234288
Lysosomal acid lipase therapy for nafld and related diseases
The present invention comprises methods and compositions for the treatment or alleviation of nafld (non-alcoholic fatty liver disease) and those conditions associated with nafld, including fatty liver disease, nonalcoholic steatohepatitis (nash) and cirrhosis through the use of pharmaceutical formulations of lysosomal acid lipase or related proteins and/or polypeptides. This invention is also directed to a combination therapy treatment for treating the metabolic syndrome.
08/21/14
20140234252
Composition and methods for the treatment of degenerative retinal conditions
The present invention is directed to compositions and methods for the treatment of degenerative retinal conditions. According to a general aspect, the present invention is directed to inflammatory mediators, preferably components or substrates of the nlrp3-inflammasome, for use in the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation.
08/21/14
20140234221
Antigen-binding proteins comprising recombinant protein scaffolds
Disclosed herein are recombinant protein scaffolds and recombinant multifunctional protein scaffolds for use in producing antigen-binding proteins in addition, nucleic acids encoding such recombinant protein scaffolds, recombinant multifunctional protein scaffolds, and antigen-binding proteins are provided vectors and cells useful for expression of the described proteins are also provided, as are methods of use.. .
08/21/14
20140234208
Dual variable domain immunoglobulins and uses thereof
Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.. .


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