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Proteins

Proteins-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Plasmids comprising internal ribosomal entry sites and uses thereof
Dana-farber Cancer Institute, Inc.
October 12, 2017 - N°20170292959

The present application relates, in some aspects, to the development of a plasmid that can be used to efficiently monitor the stabilities of thousands of proteins after specific perturbations. The plasmid allows for the co-expression of two reporter proteins, each of which is placed under the control of an ires. Other aspects of the invention relate to a plasmid library, ...
Methods for proteomic profiling using non-natural amino acids
California Institute Of Technology
October 12, 2017 - N°20170292958

The invention provides methods, reagents and systems for incorporating non-natural amino acids into proteins, preferably in vivo, using the endogenous protein synthesis machinery of an organism. The incorporated non-natural amino acids contain reactive groups for further chemical reagents, which may serve as a “handle” to enrich the proteins or fragments thereof in a number of uses, ...
Methods and devices relating to the detection of oral cancer biomarkers
Ge Healthcare Uk Limited
October 12, 2017 - N°20170292954

Disclosed is an ex vivo method for detecting plural predefined oral biomarkers within biological material present in a human oral cavity when oral cancerous activity is present in said cavity, the method comprising the steps of: i) providing a solid support for accepting a sample of biological material from the oral cavity; ii) transferring a sample of the biological material ...
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Proteins Patent Applications
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  • 271+ full patent PDF documents of Proteins-related inventions.
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Modified proteins and methods of making and using same
Life Technologies Corporation
October 12, 2017 - N°20170292156

Methods, compositions, systems, apparatuses and kits comprising modified proteins, particularly modified nucleic acid-binding proteins with altered buffering properties are provided. For example, in some embodiments, methods of forming modified proteins including one or more amino acid modifications to achieve desired pka values are described. Furthermore, the invention provides methods for using such modified proteins in ion-producing reactions, such as ion-based ...
Treatment of c9ftd/als by targeting rna expanded repeat sequences
The Scripps Research Institute
October 12, 2017 - N°20170292129

A repeat expansion in c90rf72 causes frontotemporal dementia and amyotrophic lateral sclerosis (c9ftd/als). Rna of the expanded repeat (r(ggggcc)exp) forms nuclear foci or undergoes repeat-associated non-atg (ran) translation producing “c9ran proteins”. Since neutralizing r(ggggcc)exp could inhibit these potentially toxic events, we sought to identify small molecule binders of ...
Method for selectively inhibiting acat1 in the treatment of neurodegenerative diseases
Trustees Of Dartmouth College
October 12, 2017 - N°20170292128

The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of acyl-coa: cholesterol acyltransferase 1, but not acyl-coa: cholesterol acyltransferase 2.
Proteins Patent Pack
Download 271+ patent application PDFs
Proteins Patent Applications
Download 271+ Proteins-related PDFs
For professional research & prior art discovery
inventor
  • 271+ full patent PDF documents of Proteins-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Beneficial microbes for delivery of effector peptides or proteins and use thereof
Plant Health Care, Inc.
October 12, 2017 - N°20170292108

Disclosed are recombinant host cells comprising a promoter-effective nucleic acid molecule operably coupled to a nucleic acid molecule that encodes a plant effector protein or polypeptide that induces an active plant response including, among others, growth enhancement, disease resistance, pest or insect resistance, and stress resistance. Use of these recombinant host cells for modulating plant biochemical signaling, imparting disease resistance ...
Compositions and methods for the modulation of ras proteins
New York University
October 12, 2017 - N°20170291958

Described herein is a method of modulating sumoylation of a ras protein by small ubiquitin-like modifier (sumo) proteins. Provided herein is a method for regulating the activity of a ras protein. Also provided is a treatment of proliferative diseases, such as cancer, by introducing specific mutations to a mutant ras protein that is associated with the proliferative disease. Described herein ...
Carrier-binding agent compositions and methods of making and using the same
Mayo Foundation For Medical Education And Research
October 12, 2017 - N°20170291952

Described herein are compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic. Also described are lyophilized compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic.
Antibodies specific for il-17a fused to hyaluronan binding peptide tags
Novartis Ag
October 12, 2017 - N°20170291939

The present disclosure relates to antibodies and proteins comprising an antigen-binding portion thereof that specifically bind to the pro-inflammatory cytokine il-17a and a peptide tag that binds hyaluronan (ha). The disclosure more specifically relates to specific antibodies and proteins that are il-17a antagonists (inhibit the activities of il-17a and il-17af) and are capable of inhibiting il-17...
Fgf2 truncations and mutants and uses thereof
Salk Institute For Biological Studies
October 12, 2017 - N°20170291931

The present disclosure provides fgf2 mutant proteins, such as those having an n-terminal deletion, point mutation(s), or combinations thereof, which can reduce blood glucose in a mammal. Thus, the disclosed mutant fgf2 proteins can be used to treat one or more metabolic diseases. In some examples, mutant fgf2 proteins have reduced mitogenic activity. Also provided are nucleic acid molecules ...
Modified vip3 polypeptides
Syngenta Participations Ag
October 12, 2017 - N°20170291925

The present invention is directed to vegetative insecticidal proteins (vips) modified to comprise heterologous carbohydrate binding modules and methods of use thereof.
Soluble intein fusion proteins and methods for purifying biomolecules
Merck Patent Gmbh
October 12, 2017 - N°20170291919

The present invention relates to fusion proteins comprising an n-intein polypeptide and an n-intein solubilization partner, and affinity chromatography matrices comprising such fusion proteins, as well as methods of using same.
Proteins Patent Pack
Download 271+ patent application PDFs
Proteins Patent Applications
Download 271+ Proteins-related PDFs
For professional research & prior art discovery
inventor
  • 271+ full patent PDF documents of Proteins-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Quinolones as inhibitors of class iv bromodomain proteins
Ucl Business Plc
October 12, 2017 - N°20170291875

The present invention provides compounds of formula (i) as described herein and pharmaceutically acceptable salts, hydrates and solvates thereof for use in medicine, for example in the treatment of acute myeloid leukaemia:
Humanized cc chemokine receptor 4 (ccr4) antibodies and methods of use thereof
Dana-farber Cancer Institute, Inc.
October 12, 2017 - N°20170290911

The present invention provides humanized monoclonal antibodies, bi-specific antibodies, antibody conjugates, and fusion proteins that bind to the chemokine receptor ccr4. This antibody is derived from ccr4-igg1 and recognizes the same epitope. This antibody contains either an igg4 or a stabilized igg4 in order to improve binding efficiency and reduce in vivo fab arm exchange. Binding of the antibodies ...
Peptides and combination of peptides as targets or active ingredients for use in immunotherapy against ...
Immatics Biotechnologies Gmbh
October 12, 2017 - N°20170290897

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated t-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor ...
Compositions and methods for long acting proteins
Novartis Ag
October 12, 2017 - N°20170290876

The present invention is based, in part, on the discovery of peptide tags that increase the half-life and/or mean residence time of proteins or nucleic acids in the eye. In certain aspects the invention peptide tags increase the half-life and/or mean residence time of antibodies and antigen binding fragments, therapeutic proteins, protein receptors, darpins and/or aptamers in ...
Small molecule regulators of steroid receptor coactivators and methods of use thereof
Baylor College Of Medicine
October 12, 2017 - N°20170290830

Small molecule regulators of steroid receptor coactivator (src) family proteins are provided, as well as methods for their use in treating or preventing src-related diseases. The src-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating src family proteins in a cell.
Chromobacterium subtsugae genome
Marrone Bio Innovations, Inc.
October 12, 2017 - N°20170290341

Disclosed herein is the nucleotide sequence of the chromobacterium subtsugae genome. Also provided are the nucleotide sequences of open reading frames in the c. Subtsugae genome (i. E., c. Subtsugae genes). In addition, the amino acid sequences of proteins encoded by the c. Subtsugae genome are provided. Nucleic acids, vectors and polypeptides comprising the aforementioned sequences are also provided. Homologues, ...
Chromobacterium subtsugage genes
Marrone Bio Innovations, Inc.
October 12, 2017 - N°20170290334

Disclosed herein are the nucleotide sequences of the chromobacterium subtsugae genes. In addition, the amino acid sequences of proteins encoded by the c. Subtsugae genes are provided. Nucleic acids, vectors and polypeptides comprising the aforementioned sequences are also provided. Homologues, functional fragments and conservative variants of the aforementioned sequences are also provided. Compositions having pesticidal, bioremedial and plant growth-promoting activities ...
Method for evaluation of presence of or risk of colon tumors
Applied Proteomics, Inc.
October 05, 2017 - N°20170285033

The disclosed methods are used to predict or assess colon tumor status in a patient. They can be used to determine nature of tumor, recurrence, or patient response to treatments. Some embodiments of the methods include generating a report for clinical management. The methodology provided herein is intended to detect technical variations and to allow for data normalization and enhance ...
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