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Proteins patents

      

This page is updated frequently with new Proteins-related patent applications.




 Mitochondrial preproteins as markers for alzheimer's disease patent thumbnailMitochondrial preproteins as markers for alzheimer's disease
The present invention is inter alia concerned with a method of diagnosing alzheimer's disease in a patient, wherein said method is based on determining the amount of at least one premature mitochondrial protein. Further, the present invention relates to the use of such a protein as marker for alzheimer's disease.
Albert-ludwigs-universitat Freiburg


 Method for using protein databases to identify microorganisms patent thumbnailMethod for using protein databases to identify microorganisms
A method for identifying microorganisms by maldi-tof mass spectrometry includes acquiring a maldi mass spectrum of a microorganism, detecting peaks in the acquired maldi spectrum, generating a peak list comprising mass and intensity from the detected peaks in the acquired maldi spectrum, acquiring a database of protein sequences deduced from dna sequences for microorganisms, generating a sub-database of ribosomal proteins from the protein sequences and their masses in the database, matching masses of the detected peaks in the acquired maldi spectrum to masses of the ribosomal proteins in the generated sub-database, scoring the matches obtained above for each represented microorganism, generating a peak list of accurate masses of matched ribosomal proteins, recalibrating the peak list comprising mass and intensity with the peak list of accurate masses of matched ribosomal proteins, identifying a microorganism with the highest score, and repeating until a desired improvement in the recalibrated peak list or a validated identification is achieved.. .
Virgin Instruments Corporation


 Method for determination of a protein patent thumbnailMethod for determination of a protein
The present invention concerns a method for determining the concentration of a protein in a gastrointestinal (gi) tract sample taken from a human or an animal. The present invention is characterized by the feature that a dilution of the sample in the buffered aqueous extraction medium in a range of 1:100 to 1:10,000 is obtained.
Bühlmann Laboratories Ag


 E1 enzyme mutants and uses thereof patent thumbnailE1 enzyme mutants and uses thereof
The invention provides isolated nucleic acids molecules, designated uba3, uae, or uba6, or other e1 enzyme variant nucleic acid molecules, which encode novel e1 enzyme variant proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing uba3, uae, or uba6, or other e1 enzyme variant nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a uba3, uae, or uba6, or other e1 enzyme variant gene has been introduced or disrupted.
Millennium Pharmaceuticals, Inc.


 Methods of diagnosing chronic obstructive pulmonary disease (copd) using novel molecular biomarkers patent thumbnailMethods of diagnosing chronic obstructive pulmonary disease (copd) using novel molecular biomarkers
The present invention relates to in vitro methods for the diagnosis of chronic obstructive pulmonary disease (copd), wherein the expression of the marker gene dmbt1 is determined. In particular, the invention relates to an in vitro diagnostic method of assessing the susceptibility of a subject to develop progressive copd involving the appearance of irreversible lung damage, wherein the expression of the marker gene dmbt1 and optionally one or more further marker genes selected from kiaa1199, tmsb15a, dpp6, slc51b, nudt11, elf5, azgp1, prrx1, aqp3, sfn, gpr110, gdf15, rasgrf2, rnd1, pla1a, fgg, ceacam5, hyal2, ahrr, cxcl3, cyp1a1, cyp1b1, cyp1a2, cst6, ntrk2, comp, itga10, cthrc1, tal1, fibin, bex5, bex1, esm1 and ghrl is determined.
Transgenion-international Institute For Regenerative Translation Medicine Gmbh


 Method for attaching one or more polynucleotide binding proteins to a target polynucleotide patent thumbnailMethod for attaching one or more polynucleotide binding proteins to a target polynucleotide
The invention relates to new methods of attaching one or more polynucleotide binding proteins to a target polynucleotide. The invention also relates to new methods of characterising target polynucleotides..
Oxford Nanopore Technologies Ltd.


 Bardcoded protein array for multiplex single-molecule interaction profiling patent thumbnailBardcoded protein array for multiplex single-molecule interaction profiling
Methods for attaching barcodes to polypeptides are provided. Methods for detecting molecular interactions at the single molecule level are provided.
President And Fellows Of Harvard College


 Cell culture process for producing a protein patent thumbnailCell culture process for producing a protein
The invention provides the mammalian cell culture process for the production of monoclonal antibodies and fusion proteins wherein the mammalian cell is cultured in suitable cell culture conditions specifically maintaining monophasic temperature.. .
Lupin Limited


 A  directing proteins to specific loci in the genome and uses thereof patent thumbnailA directing proteins to specific loci in the genome and uses thereof
Disclosed are compositions and methods for directing proteins to specific loci in the genome and uses thereof. In one aspect, the disclosed methods allow for directing proteins to specific loci in the genome of an organism, including the steps of providing a dna localization component and an effector molecule, wherein the dna localization component and the effector molecule are capable of being operatively linked via a non-covalent linkage..
Poseida Therapeutics, Inc.


 Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-hsv receptors patent thumbnailIdentification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-hsv receptors
The present invention provides an hsv vector comprising an envelope comprising one or more mutant gb and/or gh envelope glycoproteins, whereby the hsv vector exhibits at least 25% increased rate-of-entry after 20 minutes when assayed at 30° c. Or 37° c.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education


Novel genes encoding insecticidal proteins

The present invention relates to novel gene sequences encoding insecticidal proteins produced by bacillus thuringiensis strains. Particularly, new chimeric genes encoding a cryic, cryib or cryid protein are provided which are useful to protect plants from insect damage.
Bayer Cropscience Nv

Rhamnose promoter expression system

The prokaryotic signal sequence is selected from signal peptides of periplasmatic binding proteins for sugars, amino acids, vitamins and ions. The expression of the nucleic acid sequence is controlled by the promoter region.

Methods for producing microcompartments

To produce a bacterial microcompartment shell, or a designed shell based on naturally occurring bacterial microcompartment shells in a new host organism, a synthetic operon is constructed that contains the desired shell protein genes and translation efficiency is controlled by host specific ribosomal binding sites. proteins or other molecules can be encapsulated in the microcompartment shells by various methods described herein.
The Regents Of The University Of California

Personal vaccine and making

A method for the creation of a personalized vaccine. Multiple and varied antigens in conjunction with heat shock proteins (and other protein chaperones) are generated by ionized gas lysing coupled with the separation, concentration, and purification of these chaperone protein-antigen complexes (cpac) using insulator-dielectrophoresis (i-dep)-based devices.
Q21

Human lambda light chain mice

Genetically modified mice are provided that express human λ variable (hvλ) sequences, including mice that express hvλ sequences from an endogenous mouse λ light chain locus, mice that express hvλ sequences from an endogenous mouse κ light chain locus, and mice that express hvλ sequences from a transgene or an episome wherein the hvλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins.
Regeneron Pharmaceuticals, Inc.

Medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity

The object of the present invention relates to the new and surprising use of sulfated hyaluronic acid (has) as regulator agent of the cytokine activity (pro- and anti-inflammatory) and consequently the use of has for the preparation of a new medicine for topic use in the prevention and treatment of pathologies associated with the activation and/or deficiency of cytokines of a pro- and anti-inflammatory nature. The applicant has in fact discovered the exclusive capacity of has in modulating the activity of these particular proteins, it has studied the action mechanism and demonstrated the substantial difference between the different sulfated types known in the state of the art, but above all it has demonstrated an unexpectedly high activity of has vs different types and strains of herpes virus, cytomegalovirus and the virus of vesicular stomatitis.
Fidia Farmaceutici S.p.a.

Neutralizing antibodies and methods of use thereof

This invention provides monoclonal antibodies that recognize the toll-like receptor 4/md-2 receptor complex, and monoclonal antibodies that recognize the tlr4/md2 complex as well as tlr4 when not complexed with md-2. The invention further provides methods of using the humanized monoclonal antibodies as therapeutics.
Novimmune Sa

Dual receptor antagonistic antigen-binding proteins and uses thereof

This disclosure relates to antagonistic dual receptor antigen-binding proteins, e.g. Antibodies and methods of using the dual receptor antibodies for treatment of pathological diseases.
Amgen Inc.

Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics

This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against krtcap3, fam26f, mgc52498, fam70a or tmem154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages.
Compugen Ltd

Enantiopure haptens for nicotine vaccine development

The invention provides chiral haptens (−)-3′-amnic and (−)-n4n for use in generating antibodies in a patient specific for (−)-nicotine. The haptens can be conjugated to suitable carrier proteins and administered as an antigenic mixture, optionally comprising adjuvant(s), to a patient suffering from nicotine or tobacco addiction or habituation..
The Scripps Research Institute

Computationally optimized broadly reactive antigens for human and avian h5n1 influenza

Described herein is the generation of optimized h5n1 influenza ha polypeptides for eliciting a broadly reactive immune response to h5n1 influenza virus isolates. The optimized ha polypeptides were developed through a series of ha protein alignments, and subsequent generation of consensus sequences, based on human and avian h5n1 isolates.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education

Chemically activated nanocapsid functionalized for cancer targeting

Modified capsid proteins containing at least a portion of hepatitis e virus (hev) open reading frame 2 (orf2) having one or more cysteine residues in a surface variable loop or the c-terminus of hev orf2, or a portion thereof, are provided. The modified capsid proteins can be used to form hepatitis e virus (hev) virus like particles (vlps) having cysteine functional groups exposed on the outer-surface.
The Regents Of The University Of California

Site specific protein modifications

The present invention relates to method and reagents for use in site-selective modification of protein and peptide. The site selective modification is a selective derivation of the amino functionality at the n-terminus of the protein or the polypeptide using the presence of a neighboring histidine amino acid to increase the reactivity of the n-terminal amino functionality.
Novartis Ag

Pyrimidine compounds and methods using the same

The present invention relates to 2-amino-4-arylpyrimidine and 2-amino-4-aryltriazine compounds as inhibitors of heat shock protein 90 family of chaperone proteins. The invention also features pharmaceutical compositions and kits that include the compounds and compositions of the invention.
The Brigham And Women's Hospital, Inc.

Biosensor device and system

A system, device, and method for receiving, preparing and identifying a biological sample. Some parts may be user held and actuated.
Dnae Group Holdings Limited

Specific sorbent for binding proteins and peptides, and separation method using the same

Sorbent comprising a solid support material, the surface of which comprises first residues comprising a binuclear heteroaromatic structure comprising besides carbon atoms at least one of the heteroatoms n, o, s, and second residues comprising a mononuclear heteroaromatic structure comprising besides carbon atoms at least one of the heteroatoms n, o, s.. .
Instraction Gmbh

Personal vaccine and making

A method for the creation of a personalized vaccine. Multiple and varied antigens in conjunction with heat shock proteins (and other protein chaperones) are generated by ionized gas lysing coupled with the separation, concentration, and purification of these chaperone protein-antigen complexes (cpac) using insulator-dielectrophorsis (i-dep)-based devices.
Q21

Personal vaccine and making

A method for the creation of a personalized vaccine. Multiple and varied antigens in conjunction with heat shock proteins (and other protein chaperones) are generated by ionized gas lysing coupled with the separation, concentration, and purification of these chaperone protein-antigen complexes (cpac) using insulator-dielectrophorsis (i-dep)-based devices.
Q21

Cellular vaccine and inducing an immune response in a subject

The present invention relates to methods of inducing or enhancing an immune response against an immunogen in a subject. The invention further includes isolated nucleic acid vaccines, cellular vaccines, fusion proteins, expression vectors, vaccines, and immunogenic compositions for use therein..
Adelaide Research & Innovation Pty Ltd.

H3 influenza a virus

The invention provides an isolated h3 equine influenza a virus, as well as methods of preparing and using the virus, and genes or proteins thereof.. .
Wisconsin Alumni Research Foundation (warf)

Transmission blocking vaccines for mosquito-borne flaviviruses

Disclosed are transmission blocking vaccines for prevention or spread of one or more flaviviruses, and in particular, for prevention or spread of dengue virus. Vaccines can incorporate a polypeptide or a recombinant virus encoding a polypeptide that is non-homologous to human proteins and that is involved in flavivirus infection in a mosquito.
University Of South Carolina

Recombinant mycobacterium bovis bcg expressing antigens of the mycobacterium marinum esx-1 secretion system

Recombinant strains of mycobacterium bovis bacille calmette-guerin (m. Bovis bcg) comprising a heterologous nucleic acid sequence of mycobacterium marinum (m.
Institut Pasteur

Multi-component-multistage malaria vaccines

The present disclosure relates to novel malaria vaccines composed of different recombinant proteins, in particular recombinant fusion proteins comprising several different plasmodium falciparum antigens from the pre-erythrocytic the blood, and the sexual parasite stages. The proteins and/or fusion proteins will be used in a mixture vaccine formulation to elicit protective immune responses in humans.
Fraunhofer-gesellschaft Zur Foerderung Der Angewandten Forschung E.v.

Personal vaccine and making

A method for the creation of a personalized vaccine. Multiple and varied antigens in conjunction with heat shock proteins (and other protein chaperones) are generated by ionized gas lysing coupled with the separation, concentration, and purification of these chaperone protein-antigen complexes (cpac) using insulator-dielectrophorsis (i-dep)-based devices.
Q21

Thermostabilization of proteins

Provided are compositions comprising a cocaine esterase (coce) and a compound that thermostabilizes the coce. Also provided are methods of thermostabilizing a cocaine esterase.
The Regents Of The University Of Michigan

Methods for determining the effects of compounds on jak/stat activity

An embodiment of the present invention is a method for subjecting a hematopoetic cell to a jak/stat inhibitor, determining the activity of gain-of-function mutations of a jak family kinase, determining the expression levels and activity of jak/stat regulatory proteins, correlating the expression levels and the activity of jak/stat regulatory proteins with the activity of gain-of-function mutations of a jak family kinase and with a response to the jak/stat inhibitor, and then classifying the cells. A further embodiment of the invention includes determining the clinical outcome based on the cell classification, determining a method of treatment, determining dosing and scheduling of at least one of the jak/stat inhibitors or other compounds..
Nodality, Inc.

Nucleic acid amplification with integrated multiplex detection

Compositions and methods of detecting multiple proteins of interest in a sample using arrays are provided herein.. .
Bioarray Solutions, Ltd.

Methods for increasing molecular diversity of polyketides and non-ribosomal proteins

A method for increasing the molecular diversity of polyketides and non-ribsomomal peptides by using recombination to efficiently increase or decrease the number of modules in the polyketide synthase or non-ribosomal peptide synthetase encoding said polyketide or peptide.. .
Isomerase Therapeutics Ltd.

Activity of fe-s cluster requiring proteins

The present invention is related to a recombinant host cell, in particular a yeast cell, comprising a dihydroxy-acid dehydratase polypeptide. The invention is also related to a recombinant host cell having increased specific activity of the dihydroxy-acid dehydratase polypeptide as a result of increased expression of the polypeptide, modulation of the fe—s cluster biosynthesis of the cell, or a combination thereof.
Butamax Advanced Biofuels Llc

Hybrid proteins and uses thereof

There are disclosed hybrid proteins comprising at least one signal sequence; at least one dna binding domain; and at least one cell penetrating peptide (cpp) domain. In embodiments the cpp domain is a tat domain, and the dna binding domain is a hu domain.
Symvivo Corporation

Genetic products differentially expressed in tumors and use thereof

The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which said genetic products that are expressed in association with a tumor are expressed in aberrant manner.
Ganymed Pharmaceuticals Ag

Antigen-binding proteins that activate the leptin receptor

The present invention provides antibodies and antigen-binding fragments of antibodies that bind to leptin receptor (lepr), and methods of using the same. According to certain embodiments, the invention includes antibodies and antigen-binding fragments of antibodies that bind lepr and activate lepr signaling.
Regeneron Pharmaceuticals, Inc.

Synthetic antibody mimic peptides

The present disclosure relates to compositions and methods comprising peptide molecules that mimic the binding and functional properties of native antibodies relative to their respective targets. Some embodiments comprise peptide-drug conjugates (pdcs) comprising the mimic peptides disclosed herein.
Formurex, Inc.

Bispecific antibody fragments for neurological disease proteins and methods of use

The present invention relates to therapeutic agents comprising bispecific recombinant antibody fragments to selectively clear a protein associated with a neurological disease and methods of use of these therapeutic agents to treat neurological diseases.. .
Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of

Fusion proteins of collagen-binding domain and parathyroid hormone

Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (pth) and parathyroid hormone related peptide (pthrp) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy.
The Board Of Trustees Of The University Of Arkansas

Chimeric fibroblast growth factor 19 proteins and methods of use

The present invention relates to a chimeric protein that includes an n-terminus coupled to a c-terminus, where the n-terminus includes a portion of a paracrine fibroblast growth factor (“fgf”) and the c-terminus includes a c-terminal portion of an fgf 19 molecule. The portion of the paracrine fgf is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification.
New York University

Method for using nanoparticles as nucleation agents for the crystallization of proteins

The present invention relates to a method for the crystallization of protein using nanoparticles as nucleation agents. Precisely, the inventors performed the crystallization of such proteins as bacillus subtilis yesr, chicken egg white lysozyme, bovine serum albumin, alicyclobacillus acidocaldarius acetyl-coa carboxylase, and listeria monocytogenes hypothetical protein which have his-tag at amino terminal by using gold nanoparticles in diverse sizes and shapes in the presence of ni2+ ions.
University Of Seoul Industry Cooperation Foundation

Cement board

A cement board is provided, comprising gelatin, fiber material, and ammonium dichromate. The gelatin, the fiber material, and the ammonium dichromate are mixed substantially evenly across and formed into a board by pressure.





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