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Proteins

Proteins-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Prostate cancer-associated secreted proteins
University Of Washington
June 14, 2018 - N°20180164329

Methods are provided for treating a subject with prostate cancer and/or diagnosing a subject at risk for prostate cancer, which can include measuring increased expression of at least two prostate cancer-related molecules in a sample obtained from a subject, including the prostate cancer-related molecules agr2, agr3, crisp3, ccl3, ceacam5, ceacam6, il24, mmp9, cxcl14, cd90, postn, and sfrp4. The methods ...
4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
Visen Medical, Inc.
June 14, 2018 - N°20180164312

The invention relates to a family of compounds that comprise fluorescent cyanine dyes. The compounds are near infrared absorbing heptamethine cyanine dyes with a 4,4-disubstituted cyclohexyl ring as part of the polymethine chromophore.
High sensitivity quantitation of peptides by mass spectrometry
Anderson Forschung Group, Llc.
June 14, 2018 - N°20180164301

The instant invention provides an economical flow-through method for determining amount of target proteins in a sample. An antibody preparation (whether polyclonal or monoclonal, or any equivalent specific binding agent) is used to capture and thus enrich a specific monitor peptide (a specific peptide fragment of a protein to be quantitated in a proteolytic digest of a complex protein sample) ...
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Proteins Patent Applications
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  • 271+ full patent PDF documents of Proteins-related inventions.
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Methods for producing a paired tag from a nucleic acid sequence and methods of use ...
Applied Biosystems, Llc
June 14, 2018 - N°20180163253

Methods for producing a paired tag from a nucleic acid sequence are provided in which the paired tag comprises the 5′ end tag and 3′ end tag of the nucleic acid sequence. In one embodiment, the nucleic acid sequence comprises two restriction endonuclease recognition sites specific for a restriction endonuclease that cleaves the nucleic acid sequence distally to the restriction ...
Methods and products for producing engineered mammalian cell lines with amplified transgenes
Precision Biosciences, Inc.
June 14, 2018 - N°20180163233

Methods of inserting genes into defined locations in the chromosomal dna of cultured mammalian cell lines which are subject to gene amplification are disclosed. In particular, sequences of interest (e.g., genes encoding biotherapeutic proteins) are inserted proximal to selectable genes in amplifiable loci, and the transformed cells are subjected to selection to induce co-amplification of the selectable gene and ...
Novel recombinant adeno-associated virus capsids containing a designed ankyrin repeat protein (darpin) or fragment thereof
The Board Of Trustees Of The Leland Stanford Junior University
June 14, 2018 - N°20180163229

The present invention relates to variant aav capsid polypeptides containing designed ankyrin repeat proteins (darpins), wherein the variant capsid polypeptides exhibit an enhanced neutralization profile, increased transduction, and/or tropism in human liver and/or hepatocyte cells, or human pancreas and/or pancreatic cells, as compared to capsid polypeptides that do not include darpins.. .
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Download 271+ patent application PDFs
Proteins Patent Applications
Download 271+ Proteins-related PDFs
For professional research & prior art discovery
inventor
  • 271+ full patent PDF documents of Proteins-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Fad3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
Sangamo Therapeutics, Inc.
June 14, 2018 - N°20180163217

A method of gene editing or gene stacking within a fad3 loci by cleaving, in a site directed manner, a location in a fad3 gene in a cell, to generate a break in the fad3 gene and then ligating into the break a nucleic acid molecule associated with one or more traits of interest is disclosed.. .
Irre protein functional domain for improving anti-oxidation capability of cell and application thereof
Biotechnology Research Institute, Chinese Academy Of Agricultural Sciences
June 14, 2018 - N°20180163215

Provided is an amino acid optimization of a functional motif on an irre protein of a deinococcus geothermalis strain and homologous proteins thereof obtained by site mutation, wherein a second-site or fifth-site alanine in a functional domain motif 154laelar159 is mutated into serine.. .
Compositions and methods for degradation of misfolded proteins
The Trustees Of The University Of Pennsylvania
June 14, 2018 - N°20180163202

The present invention relates to compositions and methods for promoting the degradation of misfolded proteins and protein aggregates. The compositions and methods may be used to treat a disorder associated with misfolded proteins or protein aggregates.
Methods and systems for screening using microcapillary arrays
Xcella Biosciences, Inc.
June 14, 2018 - N°20180163198

High-throughput methods for screening large populations of variant proteins are provided. The methods utilize large-scale arrays of microcapillaries, where each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element.
Method for improving the culture conditions of cultures of primary sweat gland cells and/or ...
Henkel Ag & Co. Kgaa
June 14, 2018 - N°20180163175

The present disclosure relates to a method for improving the culture conditions of cultures of primary sweat gland cells and/or three-dimensional sweat gland equivalents, where the culture with from about 500 to about 500,000 sweat gland cells and a diameter of from about 100 to about 6,000 nm is initially prepared and then cultivated in a culture medium with neurotransmitters and/or from ...
Assembly of bispecific antibodies
Genentech, Inc.
June 14, 2018 - N°20180162955

Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule.
Psma targeting trispecific proteins and methods of use
Harpoon Therapeutics, Inc.
June 14, 2018 - N°20180162949

Provided herein are prostate specific membrane antigen (psma) targeting trispecific proteins comprising a domain binding to cd3, a half-life extension domain, and a domain binding to psma. Also provided are pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such psma targeting trispecific proteins.
Proteins Patent Pack
Download 271+ patent application PDFs
Proteins Patent Applications
Download 271+ Proteins-related PDFs
For professional research & prior art discovery
inventor
  • 271+ full patent PDF documents of Proteins-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Fusion polypeptides capable of activating receptors
Regeneron Pharmaceuticals, Inc.
June 14, 2018 - N°20180162924

A fusion polypeptide comprising (a)x-m-(a′)y, wherein a and a′ are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins which activate the target receptor.
Recombinant proteins and their therapeutic uses
Bioven 3 Limited
June 14, 2018 - N°20180162917

A recombinant protein expressing one or more human growth factors, tumor antigens, and/or receptors or epitopes thereof on or within an immunogenic expression creating a recombinant protein in which one or more epitopes are presented on the surface of the sequence in their natural configuration. The growth factor, tumor antigen, and/or receptor, sequence(s) may be expressed within ...
Methods of optimizing nucleotide sequences encoding engineered influenza proteins
Sanofi Pasteur, Inc.
June 14, 2018 - N°20180162914

The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers.
Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging
Regeneron Pharmaceuticals, Inc.
June 14, 2018 - N°20180161464

Radiolabeled anti-pd-l1 antibodies and their use in immuno-pet imaging are provided herein. Included are methods of detecting the presence of pd-l1 proteins in a patient or sample..
Antibody-sn-38 immunoconjugates with a cl2a linker
Immunomedics, Inc.
June 14, 2018 - N°20180161440

The present invention concerns improved methods and compositions for preparing sn-38 conjugates of proteins or peptides, preferably immunoconjugates of antibodies or antigen-binding antibody fragments. More preferably, the sn-38 is attached to the antibody or antibody fragment using a cl2a linker, with 1-12, more preferably 6-8, alternatively 1-5 sn-38 moieties per antibody or antibody fragment.
Fkbp52-tau interaction as a novel therapeutical target for treating the neurological disorders involving tau ...
Inserm (institut National De La Sante Et De La Recherche Medicale)
June 14, 2018 - N°20180161432

The invention relates generally to neuroprotection and repair in neurological disorders involving tau dysfunction (including alzheimer's disease). The invention describes and includes a direct interaction between proteins fkbp52 and tau.
Prostate specific membrane antigen binding protein
Harpoon Therapeutics, Inc.
June 14, 2018 - N°20180161428

Disclosed herein are psma binding proteins with improved binding affinities, and robust aggregation profiles. Also described are multispecific binding proteins comprising a psma binding protein according to the instant disclosure.
Novel method of treating macular degeneration using botulinum toxin-based pharmaceuticals
June 14, 2018 - N°20180161407

Formulations and methods of treatment are disclosed for prevention and/or treatment of visual loss from age-related macular degeneration. The disclosed formulations include botulinum neurotoxin (e.g., botulinum neurotoxin or a fragment thereof, either in pure form or with one or more peptide fragments and/or neurotoxin associated proteins).
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