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Proteins patents



      
           
This page is updated frequently with new Proteins-related patent applications. Subscribe to the Proteins RSS feed to automatically get the update: related Proteins RSS feeds. RSS updates for this page: Proteins RSS RSS


Date/App# patent app List of recent Proteins-related patents
04/16/15
20150106972
 Plant defense genes and proteins and methods of use patent thumbnailnew patent Plant defense genes and proteins and methods of use
Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding plant defense proteins are provided.
Pioneer Hi Bred International Inc
04/16/15
20150105864
 Biocompatible implants and methods of making and attaching the same patent thumbnailnew patent Biocompatible implants and methods of making and attaching the same
The invention provides a biocompatible silicone implant that can be securely affixed to living tissue through interaction with integral membrane proteins (integrins). A silicone article containing a laser-activated surface is utilized to make the implant.
Doheny Eye Institute
04/16/15
20150105352
 Combination of an hmg-coa reductase inhibitor and a farnesyl-pyrophosphatase synthase inhibitor for the treatment of diseases related to the persistence and/or accumulation of prenylated proteins patent thumbnailnew patent Combination of an hmg-coa reductase inhibitor and a farnesyl-pyrophosphatase synthase inhibitor for the treatment of diseases related to the persistence and/or accumulation of prenylated proteins
The invention relates to the use of a hydroxymethylglutaryl-coenzyme a (hmg-coa) reductase inhibitor and of a farnesyl-pyrophosphate synthase inhibitor, or of one of their associated physiologically acceptable salts, in the preparation of a composition, particularly a pharmaceutical composition, for use in the treatment of human or animal, pathological or nonpathological situations related to the accumulation and/or the persistence of prenylated proteins in cells, such as during progeria (hutchinson-gilford syndrome), restrictive dermopathy or physiological ageing.. .
Universidad De Oviedo
04/16/15
20150105293
 Clinical diagnosis of hepatic fibrosis using a novel panel of low abundant human plasma protein biomarkers patent thumbnailnew patent Clinical diagnosis of hepatic fibrosis using a novel panel of low abundant human plasma protein biomarkers
The inventors have proposed a novel panel of human plasma protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis.
The Chancellor, Masters And Scholars Of The University Of Oxford
04/16/15
20150105292
 Method for analysis of compound-binding ability of protein patent thumbnailnew patent Method for analysis of compound-binding ability of protein
A method for analyzing a binding ability of protein to a compound, involves fractionating first and second groups of proteins into plural fractions using a carrier having the compound immobilized thereon; combining fractions, analyzing the combined fractions with mass spectrometry; based on the mass spectrometry information, obtaining, regarding each fraction, an intensity ratio between peaks derived from a protein in each of the groups of fractions; and comparing degrees of the binding ability of the plural kinds of proteins to the compound.. .
Eisai R&d Management Co.,
04/16/15
20150105286
 Blid; a novel protein domain for interaction with the bcl-2 family of proteins. applications in oncology patent thumbnailnew patent Blid; a novel protein domain for interaction with the bcl-2 family of proteins. applications in oncology
In this invention, a novel protein interaction domain is provided along with several of its variants. This domain is involved in protein-protein interactions with the bcl-2 family of proteins.
04/16/15
20150105285
 Specific and high affinity binding proteins comprising modified sh3 domains of fyn kinase patent thumbnailnew patent Specific and high affinity binding proteins comprising modified sh3 domains of fyn kinase
The present invention relates to a method for the production of a library comprising recombinant derivatives of the sh3 domain of the fyn kinase of seq id no: 1 as well as a method for selecting from a library comprising recombinant derivatives of the sh3 domain of the fyn kinase of seq id no: 1 one or more of said derivatives having a specific binding affinity to a protein or peptide.. .
Eidgenoessische Technische Hochschule Zurich
04/16/15
20150105274
 Methods for the characterisation of interaction sites on target proteins patent thumbnailnew patent Methods for the characterisation of interaction sites on target proteins
The present invention relates to improved and integrated methods for the characterisation of an interaction site on a target protein that modulates the phenotype of a mammalian cell, such as a phenotype other than death and/or reduced growth. Such methods of the present invention include those to identify a target protein modulates such a phenotype of a mammalian cell, and optionally to characterise an interaction site on said target protein.
Cambridge Enterprise Limited
04/16/15
20150104867
 Animal protein-free media for cultivation of cells patent thumbnailnew patent Animal protein-free media for cultivation of cells
The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium.
Baxter Healthcare Sa
04/16/15
20150104865
 Engineered heterodimeric protein domains patent thumbnailnew patent Engineered heterodimeric protein domains
The present invention provides an engineered multidomain protein including at least two nonidentical engineered domains, each of which contains a protein-protein interaction interface containing amino acid sequence segments derived from two or more existing homologous parent domains, thereby conferring on the engineered domains assembly specificities distinct from assembly specificities of the parent domains. In particular, the engineered domains form heterodimers with one another preferentially over forming homodimers.
Merck Patent Gmbh
04/16/15
20150104849
new patent

Methods of purifying recombinant adamts13 and other proteins and compositions thereof


Provided herein are methods for purifying recombinant a disintegrin-like and metallopeptidase with thrombospondin type 1 motif 13 (adamts13) protein from a sample. The method comprises enriching for adamts13 protein by chromatographically contacting the sample with hydroxyapatite under conditions that allow adamts13 protein to appear in the eluate or supernatant from the hydroxylapatite.
Baxter International Inc.
04/16/15
20150104837
new patent

Genes encoding biofilm formation inhibitory proteins and a producing l-lysine using a bacterial strain with the inactivated genes


The present invention relates to a novel isolated gene (polynucleotide) which encodes a protein having a biofilm formation inhibitory activity derived from coryneform bacteria, a l-lysine-producing strain in which the polynucleotide is inactivated, and a method for producing l-lysine using the same.. .
Cj Cheiljedang Corporation
04/16/15
20150104829
new patent

Labeled biomolecular compositions and methods for the production and uses thereof


Disclosed herein is a set of e. Coli single-protein production (spp) technologies with protein nmr (spp-nmr) for (i) using isotope-enriched membrane proteins produced with the spp system in screening detergent conditions suitable for purification and/or three-dimensional structure analysis without the requirement for protein purification, (ii) producing 2h, 13c, 15n enriched proteins suitable for high throughput and membrane protein nmr studies, and (iii) labeling with 13c-15n specific peptide bonds in proteins (referred to herein as spp-pbl)..
Rutgers, The State University Of New Jersey
04/16/15
20150104821
new patent

Device and sorting and labeling of biological systems based on the ionic-electric dynamics


The present invention relates to a method and a device for creating digital copies of the ionic-electric dynamics of cells or cell compartments, such as organisms, or an at least partly identifying dataset that allows sorting decisions in vitro and in vivo. Sorting of cells and cell compartments based on electrical cell behavior can be applied, for instance, to transgenic compartments, in order to, e.g., detect the successful expression of certain channel proteins in an industrial process, to screen for (side) effects of certain agents or substances on the ionic-electrical cell behavior and involved proteins.
04/16/15
20150104556
new patent

Functional cream base powder composition and products made thereof


The present invention relates to a spray dried cream base powder which can be used as an alternative to dairy creams and other liquid cooking creams. The powdered cooking cream composition comprise of 20-60% by weight fat, 1-5% by weight one or more proteins, 0.5-5% by weight one or more emulsifier system, 1-6% by weight native/modified starch, 1-5% by weight water and the balance is made up of non-starchy carbohydrates, buffering agents and stabilizers.
International Foodstuffs Company Llc
04/16/15
20150104477
new patent

Ubiquitinylated proteins


A method of inducing a specific immune response in a mammal, comprising: providing a first composition comprising isolated ubiquitinylated proteins in solution in the absence of membrane bound organelles, the isolated ubiquitinylated proteins comprising one or more specific antigens, and further comprising a threshold quantity of polyubiquitinylated short-lived proteins and polyubiquitinylated defective ribosomal products. The isolated ubiquitinylated proteins are affinity-purified from tumor-derived cells grown in culture, the tumor-derived cells being inhibited from degrading ubiquitinylated proteins via the proteasome while being grown in culture.
04/16/15
20150104472
new patent

C1q peptides and uses thereof


Isolated c1q peptides, fusion proteins and compositions comprising such and fusion proteins comprising are provided. Isolated fusion proteins comprising x4wx5yx6 as defined herein and compositions comprising such are also provided.
The Feinstein Institute For Medical Research
04/16/15
20150104468
new patent

Site-specific labeling methods and molecules produced thereby


The present disclosure provides methods of site-specific labeling of antibodies, using proteins having 4′-phosphopantetheinyl transferase activity that catalyze post-translational modification of peptide sequences (“peptide tags”) incorporated into one or more specific sites of an antibody of interest. Enzymatic labeling enables quantitative and irreversible covalent modification of a specific serine residue within the peptide tags incorporated into the antibody, and thus creates desirable antibody conjugates..
Irm Llc
04/16/15
20150104452
new patent

Dual variable domain immunoglobulins and uses thereof


The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.. .
Abbvie Inc.
04/16/15
20150104451
new patent

Ctla4 fusion proteins for the treatment of diabetes


A method of treating, preventing, or delaying the progression of type 1 diabetes mellitus autoimmunity by administering an effective amount of a cytotoxic t-lymphocyte-associated antigen 4 (ctla4) molecule is provided herewith. The ctla4 molecule may be a fusion protein of a ctla4 extracellular region and an immunoglobulin, such as abatacept..
Orban Biotech Llc
04/16/15
20150104410
new patent

Serpin fusion polypeptides and methods of use thereof


This invention relates to molecules, particularly polypeptides, more particularly fusion proteins that include a serpin polypeptide or an amino acid sequence that is derived from a serpin and second polypeptide comprising of at least one the following: an fc polypeptide or an amino acid sequence that is derived from an fc polypeptide; a cytokine targeting polypeptide or a sequence derived from a cytokine targeting polypeptide; a wap domain containing polypeptide or a sequence derived from a wap containing polypeptide; and an albumin polypeptide or an amino acid sequence that is derived from a serum albumin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules..
Inhibrx Biopharma Llc
04/16/15
20150104390
new patent

All-protein implantable, resorbable reflectors


The invention provides for compositions and process for fabricating an optical reflector constructed from biocompatible and bioresorbable silk fibroin proteins. For example, the silk retroreflectors may be built based on millimeter size microprism arrays to rotate the image plane of imaged cortical layers, thus enhancing the amount of photons that are detectable in the reflected direction when inserted in a sample to be analyzed, and ultimately increasing in contrast ratio in multiphoton microscopy.
Tufts University / Trustees Of Tufts College
04/16/15
20150103591
new patent

Semiconductor memory with integrated biologic element


A memory includes cytokines, such as macromolecule proteins, as a poly-state data storage. Each fold state of multiple fold states of a protein are associated with a data value.
Toshiba America Electronic Components, Inc.
04/16/15
20150101979
new patent

Stabilized nanofibers, methods for producing, and applications thereof


A surface treatment method is described herein where a stabilizing (e.g., crosslinking agent) is pre-mixed into a fluid stock comprising a processable polymer. The stock is processed to form products (e.g., nanofibers or films), followed by exposing the products to a stabilizing (e.g., crosslinking catalyst, such as acid vapors), which results in stabilization (e.g., polymer cross-linking on the surface of the product).
Cornell University
04/09/15
20150101084

Pest resistant plants


The disclosure provides an isolated nucleic acid molecule encoding a 7-epizingiberene synthase, a chimeric gene comprising said nucleic acid molecule, vectors comprising the same, as well as isolated 7-epizingiberene synthase proteins themselves. In addition, transgenic plants and plant cells comprising a gene encoding a 7-epizingiberene synthase, optionally integrated in its genome, and methods for making such plants and cells, are provided.
Keygene N.v.
04/09/15
20150099860

Methods for separating and purifying endogenous, exogenous and recombinant proteins/peptides from plants and animals using aqueous-free, anhydrous strategies


The present invention relates to recombinant proteins/peptides from plant and animal materials, compositions comprising the proteins/peptides and methods for making them.. .
Proteins Easy Corp
04/09/15
20150099690

Compositions and methods for the delivery of molecules into live cells


The present disclosure provides methods and compositions related to the cytosolic delivery of proteins and cell-impermeable small molecules into live cells using an endosomolytic dimer of cell-penetrating peptide tat.. .
The Texas A&m University System
04/09/15
20150099656

Multiplex immuno screening assay


The present invention provides kits and assay methods for the early detection of pathogens, precise identification of the etiologic agent, and improved disease surveillance. More specifically, the present invention discloses an immunoassay leading to the rapid and simultaneous detection of antibodies to a wide range of infectious pathogens in biological fluids of infected patients.
Institut Pasteur
04/09/15
20150099636

Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex


The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.
Intrexon Corporation
04/09/15
20150099305

Detection of protein s-sulfhydration via a tag-switch technique


Methods and assays for detecting s-sulfhydration of amino acids in proteins, polypeptides and peptides are provided. The method is a two-step “tag-switch” method employing two reagents consecutively to specifically label, with a detectable label, persulfide (—s—sh) linkages in proteins, polypeptides and peptides..
Washington State University
04/09/15
20150099302

Clonal expansion of b cells


The present invention provides recombinant proteins comprising the amino acid sequence of an intracellular segment of cd40 and an amino acid sequence mediating the association of the recombinant protein with the constant region of an immunoglobulin heavy chain. The recombinant proteins according to the present invention are useful for inducing clonal expansion of a b cell having a predetermined antigen-specificity without the need for t cell or cd40l mediated co-stimulation.
Universitatsmedizin Der Johannes Gutenberg-universitat Mainz
04/09/15
20150099297

Chimeric proteins for treatment of diseases


A chimeric protein is made from the combination of (i) a pathogen recognition module derived from a scavenger receptor and (ii) an anchor domain from a different scavenger receptor. The chimeric protein binds to specific pathogens and is useful in various treatments..
Scaratech Medical Ab
04/09/15
20150099295

Recombinant production of authentic human proteins using human cell expression systems


The present invention relates to novel expression cassettes and vectors for efficiently producing authentic recombinant human proteins from stable cultures of novel human cell lines, the authentic recombinant proteins produced therefrom, and antibodies raised against those authentic recombinant proteins.. .
Humanzyme Limited
04/09/15
20150099290

Insertion of charge in the hydrophobic interior of proteins as a strategy for engineering ph-sensitive switches


Methods are provided for engineering non-naturally occurring proteins comprising artificial ph-sensitive conformational switches that respond to a change in ph by causing a global unfolding of the proteins. Non-naturally occurring proteins comprising artificial ph-sensitive conformational switches that respond to a change in ph by causing a global unfolding of the proteins are also provided..
The Johns Hopkins University
04/09/15
20150099271

Fluorescent proteins, split fluorescent proteins, and their uses


Disclosed herein are fluorescent proteins and split-fluorescent proteins (sfps) including split-green fluorescent proteins, such as tripartite split-gfps. Nucleic acid molecules encoding the fluorescent proteins and sfps, as well as methods of using the fluorescent proteins and sfps, are also disclosed.
Los Alamos National Security, Llc
04/09/15
20150099269

Hybridization- independent labeling of repetitive dna sequence in human chromsomes


The present invention discloses a transcription activator-like effector-based strategy, termed “talecolor”, for labeling specific repetitive dna sequences in human chromosomes. Tales were custom designed for human telomeric repeats and fused with any of numerous fluorescent proteins (fps).
University Of Massachusetts
04/09/15
20150098990

Peptides that target dorsal root ganglion neurons


The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (drg) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example.
Baylor College Of Medicine
04/09/15
20150098958

Influenza nucleoprotein vaccines


The present invention is related to a fusion protein comprising a variant of a nucleoprotein antigen from influenza strain a, b or c, and a variant of a c4bp oligomerization domain for increasing the cellular immunogenicity of the nucleoprotein antigen from influenza. The invention is also related to nucleic acids, vectors, fusion proteins and immunogenic compositions, for their use as a vaccine or immunotherapy for the prevention and treatment of influenza disease..
Imaxio
04/09/15
20150098950

Liquid formulations of tumor necrosis factor-binding proteins


The invention relates to a stable, pharmaceutically acceptable, aqueous formulation of tnf-binding protein, comprising a tnf-binding protein, a buffer and an isotonicity agent.. .
Ares Trading S.a.
04/09/15
20150098933

Truncated lysosomal acid lipase


Recombinant human lysosomal acid lipase (rhlal) containing an n-terminal truncation, a composition of truncated recombinant human lal (tlal), an isolated mixture comprising tlal and at least one other form of rhlal are disclosed. A method of purifying tlal from a mixture of lal proteins, pharmaceutical compositions comprising tlal and methods of producing tlal are further disclosed..
Synageva Biopharma Corp.
04/09/15
20150098875

Process for extracting natural hydroxyaptite granules from bovine bone


A process is for extracting natural hydroxyapatite from bone in order to make granules for a bone graft. The process involves soaking and boiling raw bone cubes in deionized water.
Sigmagraft, Inc.
04/02/15
20150094453

Isolated egg protein and egg lipid materials, and methods for producing the same


A method for separating proteins and fats from an egg mixture is disclosed herein. The method includes a step of microfiltration of the egg mixture, wherein microfiltration includes pumping across a filter an egg mixture containing egg yolk and egg whites (albumen).
Rembrandt Enterprises, Inc.
04/02/15
20150094270

Peptide fragments for inducing synthesis of extracellular matrix proteins


Short biologically active tetrapeptides are disclosed that are comprised of the sequences gxxg and pxxp where g (glycine) and p (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin.
Helix Biomedix, Inc.
04/02/15
20150094267

Succinimide-activated nitroxyl compounds and methods for the use thereof for nitroxylation of proteins


The present invention relates to succinimide-activated nitroxyl compounds and methods for the synthesis of such compounds. The present invention also relates to the use of succinimide-activated nitroxyl compounds to prepare nitroxylated proteins, for example nitroxylated heme proteins (e.g., nitroxylated hemoglobin and nitroxylated myoglobin).
04/02/15
20150094266

Xyloglucan and protein compositions for the treatment of intestinal disorders


Compositions include synergistic combinations of xyloglucans and vegetable or animal proteins that are useful in the treatment of intestinal disorders or of disorders originating from the intestinal system and transferred to other systems, such as the genitourinary system. The compositions include xyloglucans or an extract containing xyloglucans, and one or more animal or vegetable proteins.
Novintethical Pharma, Sa
04/02/15
20150094237

Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: determination of surface and solution dissociation constants


A method, system and device to identify, study and/or mimic carbohydrate-protein interactions on cell surfaces and in solution measured by a glycan microarray. In some instances the method, system and device uses very small quantities of carbohydrate as low as attomol.
Academia Sinica
04/02/15
20150094221

Method for indicating the presence or non-presence of prostate cancer


The present invention relates generally to the detection and identification of various forms of genetic markers, and various forms of proteins, which have the potential utility as diagnostic markers. By determining the level of a plurality of biomarkers and genetic markers in a patient sample, and combining the obtained values according to a predefined formula, it is possible to determine if it is likely that the patient suffers from prostate cancer..
Phadia Ab
04/02/15
20150094216

Systems and methods for identifying protein stabilizers


A device for studying protein conformation transformation can include a macroscopic substrate, and chaperonin proteins bound to the substrate, each chaperonin protein being capable of binding to a protein of interest during or after undergoing protein conformation transformation. The device may also include the proteins of interest bound to the substrate, where the substrate is included in a label-free assay system.
The University Of Kansas
04/02/15
20150093818

Method for generating microscopic patterns of protein and other macromolecules


Methods and apparatuses for generating microscopic patterns of macromolecules such as proteins on a solid surface are described. Pulsed laser light is used to alter surface portions of a solid surface substrate in a predetermined pattern by removing macromolecules from surface portions of the substrate where the light is focused.
Washington University
04/02/15
20150093802

Zinc finger nuclease for the cftr gene and methods of use thereof


The present invention provides new zinc finger proteins and zinc finger nuclease (zfns) that find particular using in repairing the cystic fibrosis transmembrane conductance regulator (cftr) gene.. .
The General Hospital Corporation D/b/a Massachusetts General Hospital
04/02/15
20150093782

Compositions and methods for reducing fucosylation of glycoproteins in insect cells and methods of use thereof for production of recombinant glycoproteins


Compositions for reducing fucosylation of glycoproteins in insect cells are provided. Also disclosed are methods of use of such compositions for the production of recombinant humanized proteins..
The University Of Wyoming
04/02/15
20150093767

Methods for diagnosis and prognosis of epithelial cancers


The present invention is based on the discovery that three proteins, cystatin b, chaperonin 10, and profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples.
The General Hospital Corporation D/b/a Massachusetts General Hospital
04/02/15
20150093757


Capillary electrophoresis methods for determining the relative amount of protein in a sample comprising a population of proteins are provided. The methods comprise charge and/or size separation of a target protein or a plurality of target proteins present in a sample, for example a biological sample, by capillary electrophoresis in a separation matrix comprising a haloalkane compound, and downstream detection and quantification of the total amount of protein in the sample.
Protein Simple
04/02/15
20150093742

Antibodies for oncogenic strains of hpv and methods of their use


The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to e6 proteins from at least three oncogenic strains of hpv. In general, the antibodies bind to amino acids motifs that are conserved between the e6 proteins of different hpv strains, particularly hpv strains 16 and 18.
Arbor Vita Corporation
04/02/15
20150093495

Nucleic acids, cells, and methods for producing secreted proteins


A method for producing a secreted recombinant polypeptide sequence is provided. In some embodiments it comprises providing a recombinant microorganism comprising a recombinant nucleic acid comprising a first nucleic acid sequence encoding the recombinant polypeptide sequence operatively linked to a second nucleic acid sequence encoding a signal peptide; and culturing the recombinant microorganism in a culture medium under conditions sufficient for production and secretion of the recombinant protein by the recombinant microorganism.
Pronutria, Inc.
04/02/15
20150093478

Absorbent pad to reduce confinement odor in food packages


An absorbent pad that contains activated carbon to reduce confinement odor in a vacuum-packaged food product is provided. An embodiment of absorbent pad contains activated carbon and an antimicrobial agent that further reduces confinement odor by two mechanisms of action: reducing bacterial counts in the liquid purge that cause breakdown of carbohydrates and proteins in food products; and trapping of confinement odor-causing breakdown products by the activated carbon.
Paper-pak Industries
04/02/15
20150093473

Cultures with improved phage resistance


The present invention provides methods and compositions related to modulating the resistance of a cell against a target nucleic acid or a transcription product thereof. In some preferred embodiments, the present invention provides compositions and methods for the use of one or more cas genes or proteins for modulating the resistance of a cell against a target nucleic acid or a transcription product thereof.
04/02/15
20150093414

Modified antigens


Modified rv3616c proteins and their use as medicaments, particularly for the prevention of reactivation of tuberculosis.. .
Glaxo Group Limited
04/02/15
20150093408

Lyme disease vaccine, genetic construct, recombinant protein, designing genetic construct, producing vaccine, producing recombinant proteins, use of recombinant proteins in the production of lyme disease vaccine


The present invention relates to a lyme disease vaccine, a genetic construct, recombinant protein, method for genetic construct design, method for vaccine delivery, method for recombinant proteins delivery, use of recombinant proteins in the production of lyme disease vaccine. In particular, the method concerns the use of trospa and trospa-salp15 recombinant proteins derived from castor bean tick (ixodes riccinus) as a component of lyme disease vaccine for animals.
Instytut Chemii Bioorganicznej Pan
04/02/15
20150093407

Tuberculosis tb vaccine to prevent reactivation


The present invention discloses a vaccine or immunogenic composition that can be administered to latently infected individuals to prevent reactivation of latent tuberculosis infection caused by species of the tuberculosis complex microorganisms (mycobacterium tuberculosis., m. Bovis, m.
Statens Serum Institut
04/02/15
20150093406

Modified coiled coil type proteins having improved properties


Said modified protein is in particular an antigen or a carrier protein, associated to an antigen. This modified protein has an increased affinity for negatively charged polymers such as nucleic acids or heparin, and shows an increased immunogenicity..
04/02/15
20150093404

Pcv2 orf2 protein variant and virus like particles composed thereof


Vaccination methods to control pcv2 infection with different pcv2 subtypes are disclosed. Specifically, a pcv2 subtype b (pcv2b) orf2 proteins or immunogenic compositions comprising a pcv2b orf2 protein are used in a method for the treatment or prevention of an infection with pcv2 of the same pcv2b and/or different subtype; the reduction, prevention or treatment of clinical signs caused by an infection with pcv2 of the same pcv2b or a different subtype; and/or the prevention or treatment of a disease caused by an infection with pcv2 of the same pcv2b and/or a different subtype.
Boehringer Ingelheim Vetmedica, Inc.
04/02/15
20150093396

Prostate tumor markers and methods of use thereof


Newly identified proteins as markers for the detection of prostate tumors, or as targets for their therapeutic treatment, affinity ligands capable of selectively interacting with said markers as well as methods for tumor diagnosis and therapy using the same.. .
Externautics Spa
04/02/15
20150093387

Dual variable domain immunoglobulins and uses thereof


The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.. .
Abbvie, Inc.
04/02/15
20150093384

Methods and systems for multi-antibody therapies


The present invention relates to methods and systems for administering antibody therapeutic agents. The methods include administering one or more (e.g., two or three) binding agents, wherein each of the binding agents has a binding region that is specific to a portion of a disease agent and one or more copies of a tag.
Tufts University
04/02/15
20150093377

Amino acid sequences directed against the angiopoietin/tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis


The present invention relates to amino acid sequences that are directed against proteins from the group of the angiopoietin/tie family such as tie1, tie2, ang1, ang2, ang3, ang4, angptl1, angptl2, angptl3, angptl4, angptl5, angptl6, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more of such amino acid sequences.. .
Ablynx N.v.
04/02/15
20150093289

Method for removal of viruses from blood by lectin affinity hemodialysis


The present invention relates to a method for using lectins that bind to pathogens having high mannose surface glycoproteins or fragments thereof which contain high mannose glycoproteins, to remove them from infected blood or plasma in an extracorporeal setting. Accordingly, the present invention provides a method for reducing viral load in an individual comprising the steps of obtaining blood or plasma from the individual, passing the blood or plasma through a porous hollow fiber membrane wherein lectin molecules are immobilized within the porous exterior portion of the membrane, collecting pass-through blood or plasma and reinfusing the pass-through blood or plasma into the individual..
Aethlon Medical, Inc.


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