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Proliferative

Proliferative-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Rtef-1 variants and uses thereof
Oregon Health & Science University
August 17, 2017 - N°20170233444

Disclosed are variant rtef-1 polypeptides having an rtef-1 amino acid sequence with one or more internal deletions, wherein the polypeptides reduce vegf promoter activity. Some of the rtef-1 polypeptides include an amino acid sequence that is at least 80% identical to the contiguous amino acids of 1) amino acids 24 to 47 of seq id no:15 and 2) each of seq id nos:16 and 17, but ...
Guanine analogs as telomerase substrates and telomere length affectors
Geron Corporation
August 17, 2017 - N°20170233419

This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are incorporated into telomeres by telomerase thereby inhibiting elongation of telomeres. The compounds are use in treating cancer and other cell proliferative diseases.
Thiazolyl-containing compounds for treating proliferative diseases
Dana-farber Cancer Institute, Inc.
August 17, 2017 - N°20170233411

The present disclosure provides thiazolyl-containing compounds of formula (i), (ii), or (iii). The compounds described herein may be able to inhibit protein kinases (e. G., src family kinases (e. G., hemopoietic cell kinase (hck)), bruton's tyrosine kinase (btk)) and may be useful in treating and/or preventing proliferative diseases (e. G., myelodysplasia, leukemia, lymphoma (e. G., waldenstrom's macroglobulinemia)) and in ...
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Proliferative Patent Applications
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  • 369+ full patent PDF documents of Proliferative-related inventions.
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Ido inhibitors
Bristol-myers Squibb Company
August 17, 2017 - N°20170231999

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (ido), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
Pharmaceutical composition containing dimethyl fumarate for administration at a low daily dose
Forward Pharma A/s
August 17, 2017 - N°20170231943

The present invention relates to pharmaceutical compositions containing dimethyl fumarate (dmf), more specifically, the present invention relates to a pharmaceutical composition for oral use in treating hyperproliferative, inflammatory or autoimmune disorders by administering a low daily dosage in the range of 410 mg±5% or 400 mg±5% dimethyl fumarate, wherein the pharmaceutical formulation is in the form of an erosion matrix ...
Controlled release pharmaceutical compositions comprising a fumaric acid ester
Forward Pharma A/s
August 17, 2017 - N°20170231941

The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are suitable for use in the treatment of e. G. Psoriasis or other hyperproliferative, inflammatory or autoimmune disorders and are designated to release the fumaric acid ester in a controlled manner so that local high concentrations of the active substance ...
Proliferative Patent Pack
Download 369+ patent application PDFs
Proliferative Patent Applications
Download 369+ Proliferative-related PDFs
For professional research & prior art discovery
inventor
  • 369+ full patent PDF documents of Proliferative-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Treatment of leukemias and chronic myeloproliferative diseases with antibodies to epha3
Kalobios Pharmaceuticals, Inc.
August 10, 2017 - N°20170226227

The invention provides methods and compositions comprising anti-epha3 antibodies for the treatment of myeloproliferative disorders.
Methods of diagnosing and treating hyperproliferative disorders
Rutgers, The State University Of New Jersey
August 10, 2017 - N°20170226201

The invention relates to compositions and methods for diagnosing and treating hyperproliferative disorders using ligands which specifically recognize the hypusine and/or folate binding region of mature eukaryotic translation initiation factor 5a (hypusine-containing eif-5a). The invention further relates to methods of identifying molecules which displace immunoreagents binding to mature eif-5a. Such agents are useful for treating hyperproliferative disorders.
Selective inhibitors of constitutive androstane receptor
St. Jude Children's Research Hospital
August 10, 2017 - N°20170226115

The compounds of the invention are antagonists of car, with specificity for car over other proteins including pxr. The disclosed compounds are useful in treating or controlling cell proliferative disorders, in particular oncological disorders, such as cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting ...
Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors
St. Jude Children's Research Hospital
August 10, 2017 - N°20170226094

Or a pharmaceutically acceptable salt thereof, wherein r1, r2, r3, r4 and x are as defined herein. The compounds of formula i are useful as receptor tyrosine kinase (rtk) inhibitors and can be used to treat such diseases as cancer, blood vessel proliferative disorders, fibrotic disorders, mesangial cell proliferative disorders and metabolic diseases.
Fluorinated benzofuranyl-pyrimidine derivatives containing a suflone group
Bayer Pharma Aktiengesellschaft
August 10, 2017 - N°20170226092

The present invention relates to fluorinated benzofuranyl-pyrimidine derivatives containing a sulfone group of general formula (i) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyperproliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful ...
10-substituted colchicinoids as potent anticancer agents
Council Of Scientific & Industrial Research
August 10, 2017 - N°20170226051

The present invention relates to the compounds of formula i wherein r is as herein described. The present invention particularly relates to synthesis and antiproliferative activity of 10-substituted colchicinoids. Compounds of the invention can be used for prevention or in the treatment of cancer disease.
Combination therapy
Novartis Ag
August 10, 2017 - N°20170224692

The present disclosure relates to pharmaceutical products comprising a combination of (i) a met inhibitor which is inc280 or a pharmaceutically acceptable salt or hydrate thereof and (ii) an egfr inhibitor which is an monoclonal antibody such as cetuximab or panitumumab, which are jointly active in the treatment of proliferative diseases, corresponding pharmaceutical formulations, uses, methods, processes, commercial packages and ...
Proliferative Patent Pack
Download 369+ patent application PDFs
Proliferative Patent Applications
Download 369+ Proliferative-related PDFs
For professional research & prior art discovery
inventor
  • 369+ full patent PDF documents of Proliferative-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Screening method
Isis Innovation Limited
August 03, 2017 - N°20170219594

This invention relates to a novel screening method that identifies simple molecular markers that are predictive of whether a particular disease condition is responsive to a specific treatment. Also, a method of diagnosing the susceptibility of an individual suffering from a disease to treatment with an hdac inhibitor is provided. Also provided is a method of treating a proliferative disease ...
Method for production of modified cells expressing hox and modified cells obtained by the method
Isis Innovation Limited
August 03, 2017 - N°20170218396

A cell modified for obtaining increased proliferative capacity, decreased aging and enhanced regenerative capacity, its modification involving hoxb7 overexpression obtained using a gene vector that can insert the coding sequence into the cell, thereby affording increased protein production.
Cyclin based inhibitors of cdk2 and cdk4
University Of South Carolina
August 03, 2017 - N°20170218018

Structural and functional analysis of peptide inhibitor binding to the cyclin d and cyclin a groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and inflammation.
4-aryl-n-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group
Bayer Intellectual Property Gmbh
August 03, 2017 - N°20170217949

The present invention relates to 4-aryl-n-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (i) or (ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate ...
Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group
Bayer Pharma Aktiengesellschaft
August 03, 2017 - N°20170217938

The present invention relates to fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group of general formula (i) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful ...
Aminopyrimidine derivatives for use as modulators of kinase activity
Merck Patent Gmbh
August 03, 2017 - N°20170217905

The invention provides novel heterocyclic amine compounds according to formula (i) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
4-substituted pyridine-2,6-dicarboxylic acid derivatives and method of preparing same
Okinawa Institute Of Science And Technology School Corporation
August 03, 2017 - N°20170217889

The present invention relates to novel 4-substituted pyridine-2,6-dicarboxylic acid derivatives, compounds of formula i, wherein r1 and r2 are defined herein. The compounds of formula i are useful for making pharmaceutical compositions to treat proliferative diseases. The present invention also relates to concise methods for preparing compounds of formula i that may be performed under mild reaction conditions.
Methods and compositions for enhancing t cell function and survival
Augusta University Research Institute, Inc.
August 03, 2017 - N°20170216355

It has been discovered that the inhibition of pi3k-δ, but not pi3k-α or pi3k-β, delays the terminal differentiation of cd8 t cell and maintains the tcm phenotype thus enhancing their proliferative ability and survival while maintaining their cytokine and granzyme b production ability. Methods and compositions for delaying or inhibiting terminal ...
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