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Proliferative

Proliferative-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Compositions and methods for the modulation of ras proteins
New York University
October 12, 2017 - N°20170291958

Described herein is a method of modulating sumoylation of a ras protein by small ubiquitin-like modifier (sumo) proteins. Provided herein is a method for regulating the activity of a ras protein. Also provided is a treatment of proliferative diseases, such as cancer, by introducing specific mutations to a mutant ras protein that is associated with the proliferative disease. Described herein ...
Cyclic peptide derivative, method for preparing same and composition thereof
Lotte Co., Ltd.
October 12, 2017 - N°20170291921

Provided is a cyclic peptide derivative which is derived from paecilomyces tenuipes having an astrocyte proliferative activity, or a salt thereof.
Rna polymerase i inhibitors and uses thereof
Tel Hashomer Medical Research Infrastructure And Services, Ltd.
October 12, 2017 - N°20170290842

Provided are novel compounds which are capable of inhibiting an activity of rna polymerase i, and uses thereof in treating diseases or disorders modulated by rna polymerase i, preferably autoimmune diseases such as multiple sclerosis and proliferative diseases.
Proliferative Patent Pack
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Proliferative Patent Applications
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inventor
  • 369+ full patent PDF documents of Proliferative-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Methods and nucleic acids for analyses of colorectal cell proliferative disorders
Epigenomics Ag
October 05, 2017 - N°20170283880

The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers
Academia Sinica
October 05, 2017 - N°20170283878

The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid ssea-3/ssea-4/globoh in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4galt; beta-4galnact-i; or beta-3galt-v ...
Downregulation of sine/alu retrotransposon transcription to induce or restore proliferative capacity and/or pluripotency ...
Buck Institute For Research On Aging
October 05, 2017 - N°20170283770

In certain embodiments methods are provided for inducing and/or restoring and/or maintaining a non-senescent phenotype, or aspects thereof (e. G., proliferative capacity and/or pluripotency) in a mammalian cell. The methods typically involve reducing the level or activity of sine/alu retrotransposon transcripts in the cell in an amount sufficient to induce or restore proliferative capacity and/or ...
Proliferative Patent Pack
Download 369+ patent application PDFs
Proliferative Patent Applications
Download 369+ Proliferative-related PDFs
For professional research & prior art discovery
inventor
  • 369+ full patent PDF documents of Proliferative-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Methods for treating fibroproliferative disorders in a mammal
The Texas A&m University System
October 05, 2017 - N°20170281594

A topical drug composition for treating a β-catenin-mediated disorder in a mammal is provided comprising a nefopam compound selected from nefopam, or a functionally equivalent analogue, prodrug, salt or solvate thereof.
Endosomal escape domains for delivery of macromolecules into cells
The Regents Of The University Of California
September 28, 2017 - N°20170275650

The disclosure provides fusion polypeptides and constructs useful for delivering diagnostics and therapeutics to cells. The fusion constructs include a protein transduction domain, a endosomal escape domain and a cargo domain. Also provided are methods of treating disease and disorders such as cell proliferative disorders.
Novel capsazepine analogs for the treatment of cancer and other proliferative diseases
The Board Of Regents Of The University Of Texas System
September 28, 2017 - N°20170275280

The present disclosure relates generally to derivatives of capsazepine and methods of use thereof in some aspects, the present disclosure relates to using capsazepine derivatives to treat cancer or other hyperproliferative diseases. In some aspects of the present disclosure, the disclosure provides capsazepine derivatives which may be useful in the treatment of cancer. Such cancers that the compounds may be ...
Substituted cycloalkenopyrazoles as bub1 inhibitors for the treatment of cancer
Bayer Pharma Aktiengesellschaft
September 28, 2017 - N°20170275267

Compounds of formula (i), processes for their production and their use as bub1 kinase inhibitors for the treatment of hyperproliferative diseases and/or disorders responsive to induction of cell death.
Dll3 modulators and methods of use
Abbvie Stemcentrx Llc
September 28, 2017 - N°20170274094

Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
Benzodiazepines and conjugates thereof
Immunogen, Inc.
September 28, 2017 - N°20170274091

Conjugates and compounds for making conjugates which are pbd molecules linked via the n10 position are disclosed, along with the use of the conjugates for treating proliferative diseases, including cancer.
Techniques of preparing collagen active peptides
Baotou Dongbao Bio Tech Co Ltd
September 21, 2017 - N°20170267746

A method of preparing collagen active peptides with antiproliferative activity against cancer cells. The collagen active peptides are obtained by hydrolysis of papain and trypsin and a specific purifying process. The collagen active peptides have antiproliferative activity against cancer cells, such as ovarian carcinoma cells including skov3, ovcar3, 436 and sro82 and the prostate cancer cells including pc3, lncapc1, and lncapc2.
Proliferative Patent Pack
Download 369+ patent application PDFs
Proliferative Patent Applications
Download 369+ Proliferative-related PDFs
For professional research & prior art discovery
inventor
  • 369+ full patent PDF documents of Proliferative-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Indazoles
Cancer Research Technology Ltd.
September 21, 2017 - N°20170267675

The invention provides novel substituted indazole compounds according to formula (i), their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.
Anti-dll3 antibody drug conjugates for treating cancer
Abbvie Stemcentrx Llc
September 21, 2017 - N°20170266315

Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
Methods of making dll3 antibody drug conjugates
Abbvie Stemcentrx Llc
September 21, 2017 - N°20170266314

Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
Methods of delivering dll3 antibody drug conjugates
Abbvie Stemcentrx Llc
September 21, 2017 - N°20170266313

Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
Anti-dll3 antibody drug conjugates
Abbvie Stemcentrx Llc
September 21, 2017 - N°20170266312

Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
Cyp2j2 antagonists in the treatment of pain
Fraunhofer-gesellschaft Zur FÖrderung Der Angewandten Forschung E.v.
September 21, 2017 - N°20170266169

The present invention pertains to novel treatments of neuropathic pain; in particular chemotherapy induced peripheral neuropathic pain (cipnp). The invention provides antagonists cytochrome p450 epoxygenases (cyp), and more specifically antagonists of cyp2j2, as therapeutics for use in the treatment of neuropathic pain such as cipnp. Cyp2j2 antagonists were identified to alleviate cipnp in-vivo, and therefore are provided additionally ...
Sortase-modified molecules and uses thereof
Research Development Foundation
September 14, 2017 - N°20170260517

Cell-targeted cytotoxic agents, including sortase serine protease constructs, are provided. Such compounds can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e. G., cancer). In some aspects, recombinant sortase serine proteases, such as granzyme b polypeptides, are provided that exhibit improved stability and cell toxicity.
Substituted benzylindazoles for use as bub1 kinase inhibitors in the treatment of hyperproliferative diseases
Bayer Pharma Aktiengesellschaft
September 14, 2017 - N°20170260198

Compounds of formula (1) which are inhibitors of bub 1 kinase, processes for their production and their use as pharmaceuticals.
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