|| List of recent Proliferation-related patents
|Culture stable proliferation of pluripotent stem cell while maintaining undifferentiated state|
Cultivating a pluripotent stem cell in a medium comprising at least one member selected from the group consisting of ethanolamine, an ethanolamine analog, and a pharmaceutically acceptable salt thereof, and which is substantially free of β-mercaptoethanol or contains β-mercaptoethanol at a concentration of not more than 9 μm, and the like, is effective for the proliferation of a pluripotent stem cell while maintaining an undifferentiated state.. .
Ajinomoto Co., Inc.,
|Omega-amino acid derivatives of benzene, pyridine, and pyridazine compounds|
Wherein r1, r2, r3, r4, r5, r6, r7, n, q1, q2, q3, y, and x1-x4 are as defined herein. Compounds of formula i are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like.
|Method of treating peripheral artery diseases in lower limbs|
A method of treating peripheral artery diseases in lower limbs by providing a medical device having an expandable member having a drug coating layer which has a crystalline morphological form including a plurality of crystal particles of a water-insoluble drug regularly arranged and uniformly sized on the surface of the medical device, inserting the medical device in peripheral blood vessels, expanding the expandable member, pressing the drug coating layer to a blood vessel wall such that at least part of the plurality of crystals are transferred to the blood vessel wall, and deflating the expandable member such that a pharmacokinetics profile is presented in which a drug concentration in the blood vessels is kept for the inhibition of smooth muscle cell proliferation in a high drug-concentration period of time, and for the non-inhibition of endothelial cell growth in a later low drug-concentration period of time.. .
Terumo Kabushiki Kaisha
|Cell lines that secrete anti-angiogenic antibody-scaffolds and soluble receptors and uses thereof|
The invention provides nucleic acid and polypeptide sequences encoding antibody based scaffolds such as full antibodies, antibody fab fragments, single chain antibodies, soluble vegf receptor-fc fusion proteins, and/or anti-angiogenic pdgf receptors. Also encompassed are cell lines encoding such anti-angiogenic antibody scaffolds, vegf receptors, and/or pdgf receptors.
Neurotech Usa, Inc.
The purpose of the present invention is to provide a composition for effectively inducing apoptosis and/or proliferation inhibition in a cell, and a method using the same. An agent for inducing apoptosis that comprises as active ingredients a drug inhibiting gst-π and a drug inhibiting akt; a medicinal composition comprising the same; a method for treating a disease caused by abnormality in apoptosis using the same, etc..
Nitto Denko Corporation
|Thioether derivatives as protein kinase inhibitors|
The present invention relates to thioether derivatives (1) as protein kinase inhibitors, which are useful for the treatment, relieve and/or prevention of diseases associated with abnormal and hyperproliferation of cells in a mammal, especially humans, and which are particularly useful for the treatment of all forms of cancer.. .
Ktb Tumorforschungsgesellschaft Mbh
|Therapeutic use of antibodies to hgf|
The present invention is directed to antibodies and fragments thereof (especially chimeric and humanized) having binding specificity for hgf and their use in therapy and diagnosis. These antibodies inhibit or block hgf-associated activities including hgf's effects on cell proliferation, invasion, angiogenesis, metastasis and fibrosis.
Alderbio Holdings Llc
Wherein the groups a, r1 to r2 and x have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament..
|Triazole derivatives as wnt signaling pathway inhibitors|
Such compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the wnt pathway and increased presence of nuclear β-catenin. For example, these may be used in preventing and/or retarding proliferation of tumor cells and metastasis, for example carcinomas such as colon carcinomas..
|Anti-proliferative effects of palm vegetation liquor and extracts thereof in preventing pancreatic cancer|
Present invention relates to a composition to inhibit cancer cell proliferation, wherein said composition comprises oil palm extracts. The composition is useful for prevention of pancreatic cancer by inhibiting clonogenicity, inducing apoptosis, regulating gene expression, inducing anti-invasive effect, and induces cell cycle arrest in s phase.
Malaysian Palm Oil Board
Sulfated-oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol 25-hydroxycholesterol-3-sulfate (25hc3s) to the subject e.g.
Virginia Commonwealth University
Application of maltotriose-coated 4th generation polypropyleneimine dendrimer ppi-g4-ds-mal-iii
The application of maltotriose-coated 4th generation polypropyleneimine dendrimer ppi-g4-ds-mal-iii containing 80-95% of peripherial amines groups coated with maltotriose particles to make a drug for treating neoplastic proliferation diseases, particularly chronic lymphocytic leukemia.. .
Mailport for automated parcel carriers
A mailport that solves a variety of problems caused by the proliferation of automated parcel carriers, including unmanned aerial vehicles (“uavs”). The preferred embodiment of the invention features an access aperture designed to retrieve and transfer packages to and from automated parcel carriers.
Method of determining the probability of a therapeutic response in cancer chemotherapy with cardiac glycoside
A prognostic assay and kit and method of use thereof are provided. The kit and assay are used to determine the likelihood of a diseased cell or tissue having a therapeutic response to treatment with a cardiac glycoside in a disease having an etiology associated with excessive cell proliferation.
Phoenix Biotechnology, Inc.
Method for activation of stem cell proliferation and increase of stem cells resistence to negative impacts
Method for activation of stem cells' proliferation and increase in the resistance of the stem cells to negative impacts, without use of high-frequency electro-magnetic field, is provided. The technical result is achieved due to the treating of the cells culture with a weak low-frequency magnetic field.
Method for preserving proliferation and differentiation potential of undiffrentiated cells
A method for preserving proliferation and differentiation potential of undifferentiated cells, has steps of providing a culture carrier having a surface coated with a biological material selected from the group consisting of hyaluronan, chondroitin sulfate, carboxymethyl cellulose, carrageenan, alginate, and chitosan; and inoculating and culturing the undifferentiated cells on the surface in the culture carrier with an appropriate medium, such that the proliferation and differentiation potential of undifferentiated cells are preserved. The method can be used for expanding stem cells in vitro without loss of their replicative ability and differentiation capacity.
National Cheng Kung University
Preventive or remedy for inflammatory disease
The present inventors obtained, from a phage library of human antibodies, an anti-mouse nr 10 neutralizing antibody-expressing bm095 clone that shows a strong proliferation-suppressing activity in an il-31-dependent ba/f3 cell proliferation assay system. When this anti-mouse nr 10 neutralizing antibody was administered to nc/nga mice, a model of atopic dermatitis which is a mouse model of chronic dermatitis that arises as a result of repeated applications of picryl chloride, a mouse model of rheumatoid arthritis, and a mouse model of osteoarthritis, a significant effect of symptom suppression was observed.
Chugai Seiyaku Kabushiki Kaisha
Anti-human vegf antibodies with unusually strong binding afinity to human vegf-a and cross reactivity to human vegf-b
Murine and humanized anti-human vegf antibodies and uses are disclosed. The anti-human vegf antibodies of the invention have higher binding affinity for human vegf-a, are stronger inhibitors of the vegf-a induced proliferation of endothelial cells in culture as compared with anti-human vegf antibodies in the art.
Combination uses of dichloroacetate and oxamate, and their prodrugs, for cancer treatment
The invention novel compounds, pharmaceutical compositions and methods useful for preventing or treating cancer in animals and humans. Also, the invention provides novel prodrugs useful for reducing tumor size, and inhibiting the growth of cancers, inhibiting tumor cell growth and tumor cell proliferation, and promoting apoptosis of tumor cells.
P16ink4a derived peptides for prophylaxis and therapy of hpv-associated tumors and other p16ink4a expressing tumors
Described are particular fragments of the cyclin-dependent kinase inhibitor p16 capable of increasing ifn-γ secretion of t cells or inducing proliferation of t cells and the use of said fragments for immunizing an individual against hpv-associated or other p16ink4a expressing carcinomas, preferably advanced carcinomas.. .
Nad biosynthesis and precursors for the treatment and prevention of cancer and proliferation
The invention relates to methods for treatment and prevention of cancer by administering agents that increase levels of nad+, such as nad+ precursors or agents involved in nad+ biosynthesis.. .
Method for treating cell proliferation disorders
Methods, compositions and products for treating or reducing a cell proliferation disorder, such as hand and foot syndrome or cutaneous t cell lymphoma, in a subject in need thereof are described. The methods involve topically administering to the subject a composition containing an α adrenergic receptor agonist, such as brimonidine..
Galderma Research & Development
Methods for diagnosing and treating prostate cancer
The invention is directed to a method of inhibiting prostate cancer cell proliferation using a substance that inhibits the activity of a soluble adenylyl cyclase (sac) protein. The invention also is directed to methods of diagnosing and prognosticating prostate cancer in a subject by evaluating sac gene or protein expression in the subject..
Methods of screening for cell proliferation or neoplastic disorders
The invention relates to methods and compositions for identifying subjects having, or predisposed to having, a neoplastic or cell proliferation or neoplastic disorder. The methods are applicable to any type of tissue sample and can be conducted on otherwise normal tissue..
National Institute Of Health
Composition for promoting differentiation and proliferation of neural stem cell and neural precursor cell
The present invention relates to a composition containing soyasaponin i for promoting differentiation or proliferation of neural stem cells or neural precursor cells. The composition may be usefully used as a composition for culturing cells in order to promote differentiation or proliferation of neural stem cells or neural precursor cells, and may be used to prevent or treat various neurological diseases caused by degenerative brain diseases and nerve damage by promoting differentiation and regeneration of neurons suitable for the transplantation sites..
University-industry Cooperation Group Of Kyung Hee University
Suspension culture of human embryonic stem cells
This disclosure provides an improved system for culturing human embryonic stem cells. The cells are cultured in suspension so as to maximize the production capacity of the culture environment.
Asterias Biotherapeutics, Inc.
Mimetic peptides derived from collagen type iv and their use for treating angiogenesis- and lymphangiogenesis- dependent diseases
Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other angiogenesis-dependent diseases are disclosed. More particularly, active non-cysteine analogs (mimetics), which exhibit anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer sonogram models and age-related macular degeneration models are disclosed.
The Johns Hopkins University
Medicament for atrophy treatment or increasing cell growth
The present invention provides serf2, a nucleic acid encoding said serf2 or a cell expressing serf2 for use as a medicament, in particular for use for use in treating or preventing an atrophy disease or condition or for increasing cellular growth in a patient such as sarcopenia, cachexia, dystrophy, hypoplasia, hypotonia, or muscle loss, as well as in vitro methods suitable for cell culture proliferation and pharmaceutical compositions.. .
Simu Trade Consulting Gmbh & Co. Leasing Kg
Use of sulphated glycolipids as promoters of neuritic growth, myelination and inhibiting the proliferation of astroglia and microglia
A compound having formula i, in which r1 is an alkenyl group c5-c25 containing one or more double carbon-carbon bonds, r2 is selected independently from the group consisting of methyl and fluorinated methyl, and r3 and/or r4 is a so3m group, in which m is selected from the group consisting of hydrogen, alkali metal, ammonium and quaternary amine, the other being hydrogen or acyl is provided. The compound can be used for the production of a drug for the treatment of central nervous system disorders selected from the group consisting of lesions caused by cns trauma, demyelinating diseases, neuro-inflammatory diseases and mental disorders caused a low level of bdnf..
FundaciÓn Del Hospital Nacional De ParaplÉjicos Para La InvestigaciÓn Y La IntegraciÓn (fuhnpaiin)
Substituted triazolo-pyrimidine compounds for modulating cell proliferation, differentiation and survival
Disclosed herein are erythropoietin-mimetic compounds of formula i, which modulate the survival, function, or differentiation of, for example, kidney cells, neurons, erythroid cells, or other erythropoietin-responsive cells. The present invention also relates to compounds and methods that preferentially modulate cells expressing the tissue-protective erythropoietin receptor.
Devices and methods for inhibiting stenosis, obstruction, or calcification of a native heart valve, stented heart valve or bioprosthesis
The present invention relates to methods for inhibiting stenosis, obstruction, or calcification of a valve following implantation of a valve prosthesis or a native valve which develops disease via the lrp5/wnt pathway in the presence of elevated lipids due to elevated low density lipoprotein. This invention involves dispensing a combination of medications to target inflammation and attachment of the target cell and the secondary drugs to inhibit proliferation and calcification on an elastical stent, gortex graft or valve leaflet.
Treatment of bone-related cancers using placental stem cells
Provided herein are methods of suppression of proliferation and growth of cells of bone-related cancers, e.g., multiple myeloma or chondrosarcoma cells, using placental cells, e.g., the placental stem cells described herein, and populations of such placental cells. Also provided herein are methods of treating individuals having cells of a bone-related cancer..
Application of maltotriose-coated 4th generation polypropyleneimine dendrimer ppi-g4-os-mal-iii
The application of maltotriose-coated 4th generation polypropyleneimine dendrimer ppi-g4-os-mal-iii containing 25-45% of peripheral amines groups coated with maltotriose particles to make a drug for treating neoplastic proliferation diseases, particularly chronic lymphocytic leukemia.. .
Nanoliposomal c-myc-sirna inhibits in vivo tumor growth of cisplatin-resistant ovarian cancer
The present invention discloses c-myc-sirna formulation as a potential therapeutic target for cisplatin-resistant ovarian cancer. It is disclosed targeting c-myc with small interfering rna (sirna) in the cisplatin-resistant ovarian cancer cell line inducing a significant cell growth arrest and inhibition of cell proliferation.
Protective ingredient of skin barrier and cosmetic and/or dermatologic formulation containing the same
The present invention describes a skin barrier protective ingredient and a cosmetic and/or dermatological formulation containing the same and which, according to its general features, basically provides a skin barrier protective ingredient from an apple (malus sp.) extract fraction incorporated into liposomes (soy lecithin) in specific concentrations in order to impart to this liposome-encapsulated apple (malus sp.) extract fraction a differentiated moisturising activity that protects the skin and minimises the signs of ageing, in that it reinforces and enhances the skin barrier function, induces the proliferation and differentiation of epidermis cells (keratinocytes), develops the epidermis, regulates cell development and differentiation, promotes blood circulation and activates the metabolism of skin ceramides.. .
Botica Comercial FarmacÊutica Ltda
Advanced viscoelastic antimicrobial compositions and methods
Viscoelastic compositions capable of preventing microbial proliferation and capable of capturing microbial membrane and cell wall decomposition products are provided. The compositions comprise thermal reaction products of blends of fatty acids derived and isolated from drying and semi-drying oils such as linseed, safflower, and tung oil, with a polymer component such as for example poly (isobutyl methacrylate).
Mycelx Technologies Corporation
Cell based quality control bioassays for nutriceutical and medicinal products
A method for determining the translation initiation inhibitory potency of a composition having an unknown level of translation initiation inhibitory activity which comprises contacting an ei-f2α-wt cell with said composition for a time and at a temperature effective to inhibit proliferation of said cell, measuring the level of inhibition of proliferation of said eif2α-wt cells induced by said sample and comparing the level of inhibition of proliferation induced by said sample with the level of inhibition of proliferation induced by a standard having a known amount of said activity, the amount of said translation initiation inhibitory activity in said sample being proportional to the level of inhibition of proliferation of said eif2α-wt cell.. .
President And Fellows Of Havard College
Immobilised cyclin-dependent kinase 4 fusion proteins and uses thereof
The present invention concerns an in vitro assay for determining the activation status of endogenous cdk4 in eukaryotic cells, said assay comprising the steps of: providing eukaryotic cells maintained in a quiescent state, said eukaryotic cells comprising a cyclin d/cdk4 fusion protein, wherein the cdk4 part of the fusion protein is present in a hypophosphorylated form; inducing proliferation of said eukaryotic cells; isolating the cyclin d/cdk4 fusion protein from said eukaryotic cells; and measuring the activation status of said isolated cyclin d/cdk4 fusion protein, thereby determining the activation stats of endogenous cdk4 in said eukaryotic cells.. .
Universite Libre De Bruxelles
Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation..
Cell culture supplements
The invention relates to cell culture supplements based on a platelet rich plasma fraction and a platelet poor plasma fraction. The supplements increase cell proliferation rate, improve selection of clonogenic cells, proliferation of cells from biopsies from elderly patients, maintenance of cell differentiation potential, and in vitro expansion of cell cultures also starting from an extremely low number of initially plated cells.
Biorigen International Sa
Medium for yeasts
In order to provide a culture medium eliminating variation by lot of component concentrations, the present invention provides a culture medium, and preferably a chemical-synthetic culture medium, imparting a proliferation ability to yeast that is equivalent to or greater than that of a ypd culture medium. A culture medium is provided which includes sugars as a carbon source capable of being assimilated by yeast; amino acids as a nitrogen source; vitamins; inositol; zinc ion (zn2+); potassium ion (k+), and magnesium ion (mg2+), and in which inositol concentration is between 50 and 10,000 mg/l..
Kohjin Life Sciences Co., Ltd.
Human anti-cd27 antibodies, methods and uses
Human antibodies immunospecific for human cd27 are capable of blocking cd27 binding to its ligand cd70 and neutralizing bioactivity of cd27 including, but not limited to, cd27 intracellular signaling, t-cell proliferation and activation, b-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by cd70, and the production of soluble mediators from t and b-cells. The antibodies are useful in diagnosing or treating cd27 activity associated diseases and conditions..
Janssen Biotech, Inc.
Complex-formation-modulating agents and uses therefor
Disclosed are methods and agents for modulating proliferation, migration and/or survival of cells. More particularly, the present invention discloses molecules that have any one or more activities selected from: inhibiting binding of vitronectin to at least one vitronectin-binding partner selected from an igf and igfbp, inhibiting formation of a complex comprising vitronectin and at least one vitronectin-binding partner selected from an igf and igfbp, or inhibiting proliferation or survival of a hyperproliferative cell (e.g., a neoplastic cell or non-neoplastic cell), or inhibiting migration or invasion of a hyperproliferative cell (e.g., a neoplastic cell or a non-neoplastic cell).
Queensland University Of Technology
Compositions and methods for modulating innate and adaptive immune systems
Compositions and methods for modulating the innate and adaptive immune systems in a subject. The compositions and methods may inhibit the function of inhibitory receptors and enhance activity of activating receptors.
Susavion Biosciences, Inc.
Compositions and methods for modulating innate and adaptive immune systems
Compositions and methods useful in modulating the innate and adaptive immune systems in a subject, including activation of natural killer (nk) cells and/or cd8+ cytotoxic t lymphocytes. The method typically comprises: administering to the subject a composition comprising a therapeutic peptide or a multivalent structured polypeptide comprising multiple copies of the therapeutic peptide described herein in an amount sufficient to increase activity of nk cells and/or cd8+ cytotoxic t lymphocytes in the subject.
Susavion Biosciences, Inc.
Use of hydroxycinnamaldehyde glycoside derivatives for treating glomerulonephritis
The present invention relates to a new use of a cinnamaldehyde derivative of formula (i) for treating glomerulonephritis (gn). Particularly, the present invention discloses that the cinnamaldehyde derivative of formula (i) is effective in treating glomerulonephritis (gn), which can alleviate various symptoms and signs of gn, including reducing proteinuria, serum blood urea nitrogen (bun), glomerular cell proliferation, and renal macrophage/lymphocyte infiltration, etc..
National Defense Medical Center
Tricyclic lactams for use in hspc-sparing treatments for rb-positive abnormal cellular proliferation
This invention is in the area of tricyclic lactam compounds for and methods of treating selected rb-positive cancers and other rb-positive abnormal cellular proliferative disorders while minimizing the deleterious effects on healthy cells, for example healthy hematopoietic stem cells and progenitor cells (hspcs), associated with current treatment modalities. In one aspect, treatment of select rb-positive cancers is disclosed using specific compounds disclosed herein.
G1 Therapeutics, Inc.
Novel amine derivative or salt thereof
(in the formula: g1, g2, and g3 are the same or different and represent ch or a nitrogen atom; r1 represents a chlorine atom, an optionally-substituted c3-8 cycloalkyl group, or the like; r2 represents —coor5 (in the formula, r5 represents a hydrogen atom or a carboxyl protective group), or the like; r3 represents a hydrogen atom, or the like; and r4 represents an optionally-substituted condensed bicyclic hydrocarbon group, an optionally-substituted bicyclic heterocyclic group, or the like), or a salt thereof is useful in procedures such as the treatment or prevention of conditions related to excessive keratinocyte proliferation.. .
Inhibitors of bruton's tyrosine kinase
The invention provides novel poly-substituted 5-membered heterocyclic compounds represented by formula (iv), or a pharmaceutically acceptable salt, solvate, metabolites, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as selective irreversible bruton's tyrosine kinase (btk) inhibitors and is further useful to treat inflammatory, auto immune diseases associated with aberrant b-cell proliferation such as ra (rheumatoid arthritis) and cancers.
Centaurus Biopharma Co., Ltd.
Crystal form of chidamide, preparation method and use thereof
The present invention belongs to the field of pharmaceutical chemistry, and disclosed are two crystal forms of childamide, that is, chidamide crystal form a and chidamide crystal form b, and the method for preparing the new crystal forms of chidamide. The chidamide crystal form a and chidamide crystal form b of the present invention can be used for preparing drugs for treating diseases related to cell differentiation and proliferation..
Shenzhen Chipscreen Biosciences, Ltd.
Methods and compositions for treatment of cancer by inhibition of nr2f2
The current invention discloses compositions of matter, protocols and methods of use of treatment for cancer and other diseases of aberrant cellular proliferation and differentiation by inhibiting expression of nr2f2 or activity thereof. In one embodiment, administration of synthetic oligonucleotides that induce rna interference mediated degradation of the nuclear receptor nr2f2 in human or animal patients is performed at a sufficient concentration or frequency to achieve regression of tumor..
Compositions including triciribine and taxanes and methods of use thereof
This application relates to combination therapies including triciribine and related compounds and taxanes and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. .
University Of South Florida
Compounds for use in polycystic kidney disease
Polycystic kidney disease is a cystic genetic disorder of the kidneys. Recent identification of signaling cascades de-regulated in pkd has led to the initiation of several clinical trials, but an effective therapy is still lacking.
Methods and compositions for treating progesterone-dependent conditions
The subject matter of the instant invention is pertinent to the field of treatment of hormone-dependent conditions. Methods for treating these conditions are provided comprising systemically administering an antiprogestin and contemporaneously locally administering an antiprogestin.
Repros Therapeutics Inc.
Novel selenium-containing compound
The invention provides a method of improving an antioxidant effect in a redox pathway that involves selenium in a subject, an in vitro method of inhibiting oxidation in a cell or tissue, and an in vitro method of promoting proliferation of a cell, by use of a selenium-containing compound of chemical formula 1:. .
Fisheries Research Agency
Novel forming hydrogel arrays using surfaces with differential wettability
Patterned hydrogel arrays and methods of preparing patterned hydrogel arrays are disclosed. Advantageously, the methods used to prepare the patterned hydrogel arrays allow for controlling individual hydrogel spot conditions such as hydrogel spot modulus, hydrogel spot ligand identity and hydrogel spot ligand density, which allows for preparing a wide range of hydrogel spots in a single array format.
Methods and compositions for treatment of cancer by inhibition of nr2f6
The current invention discloses compositions of matter, protocols and methods of use of treatment for cancer and other diseases of aberrant cellular proliferation and differentiation by inhibiting expression of nr2f6 or activity thereof. In one embodiment, administration of synthetic oligonucleotides that induce rna interference mediated degradation of the nuclear receptor nr2f6 in human or animal patients is performed at a sufficient concentration or frequency to achieve regression of tumor..
Hydrogel compositions for use in promoting tubulogenesis
Hydrogel compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation.
Chimera comprising bacterial cytotoxin and methods of using the same
This invention provides, a recombinant polypeptide encoding a chimera. The chimera includes a dnase i fragment or a homologue thereof and a cdt fragment or a homologue thereof.
Functionalized 9-bromo-camptothecin derivatives
The present invention relates to new functionalized 9-bromo-camptothecin derivatives (i) which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical composition containing them.
Novel tetrazolo hydrazine derivatives and pharmaceutical composition comprising same as active ingredient for preventing or treating cancer
Provided are novel tetrazolo hydrazone derivatives or pharmaceutically acceptable salts thereof. The derivatives and the salts may inhibit the proliferation of cancer cells in a low molar concentration and inhibit the activity of cancer cells through the regulation of expression of apoptosis-related genes or the like, thus expressing excellent anti-cancer activity, and therefore, can be used effectively in preventing or treating cancer..
Inhibitors of bruton's tyrosine kinase
This application discloses compounds according to generic formula (i): wherein all variables are defined as described herein, which inhibit btk. The compounds disclosed herein are useful to modulate the activity of btk and treat diseases associated with excessive btk activity.
Compositions and methods for diagnosis and treatment of malignant gliomas
The present application provides compositions and methods useful for the diagnosing and treating malignant gliomas. As described herein, the compositions and methods are based on the development of hla class ii binding peptides and peptide antigens encoded by the mage-a3 and il-13rα2 tumor associated genes, which stimulate the activity and proliferation of cd4+ t lymphocytes.
Methods of enhancing functioning of the large intestine
The invention relates to glucagon-related peptides and their use for the prevention or treatment of disorders involving the large intestine. In particular, it has now been demonstrated that glp-2 and peptidic agonists of glp-2 can cause proliferation of the tissue of large intestine.
Pharmaceutical compositions and methods
Pharmaceutical compositions and kits including a tyrosine hydroxylase inhibitor; melanin, a melanin promoter, or a combination thereof; a p450 3a4 promoter; and a leucine aminopeptidase inhibitor are provided. Also provided are methods of treating cancer in a subject, comprising administering an effective amount of a tyrosine hydroxylase inhibitor, a melanin promoter, a p450 3a4 promoter, and a leucine aminopeptidase inhibitor to the subject in need thereof.
Diffusible factors and cancer cells
The present invention relates to modified cancer cells that are defective in the production of diffusible factors (e.g., growth factors), and to the use of such cells for impairing the growth of a population of human cells, in particular wherein the cells are human cancer cells and the population of cells is a neoplasm, tumour or cancer. The invention preferably comprises the step of modifying tumour cells by deleting or modifying endogenous genes that code for (or affect the production of), diffusible growth factors that promote cell survival and proliferation..
Inhibitors of bruton's tyrosine kinase
This application discloses compounds according to generic formula i wherein all variables are defined as described herein, which inhibit btk. The compounds disclosed herein are useful to modulate the activity of btk and treat diseases associated with excessive btk activity.
Tray dispenser and use thereof
The invention relates to a tray dispenser (1) for dispensing of trays for packaging where the tray dispenser includes a tray dispenser cassette (2) and a base station (3) which can be placed on a stand (6) and where the tray dispenser cassette (2) can be connected to the base station. The base station (3) contains electronic components and at least one motor (19) which, via a mechanical coupling (18) can operate the tray dispenser cassette containing mechanical components made only of materials that are corrosion resistant.
Proliferation-associated modulation of the splicing of the integrin alpha 6 isoforms
The present disclosure relates to the use of the ratio between the b and a isoforms of the α6 integrin in the diagnosis of diseases associated with an altered proliferation rate, such as cancer (especially a cancer of the gastro-intestinal track), in humans.. .
Socpra Sciences Sante Et Humaines S.e.c.
Adam-15 antibodies and immunogenic peptides
The present invention relates to antibodies and antigen-binding fragments thereof, immunogenic peptide(s), and sirna molecules which are capable of inhibiting neovascularization and/or angiogenesis and endothelial cell proliferation. The invention relates to antibodies and antigen-binding fragments thereof with specificity towards the metalloprotease domain of adam 15 and to immunogenic peptide(s) that elicits such antibodies.
Methods for protecting dopaminergic neurons from stress and promoting proliferation and differentiation of oligodendrocyte progenitors by nrg-2
The invention features methods of treatment and diagnosis using nrg-2 polypeptides, nucleic acid molecules, and antibodies. The invention also provides novel nrg-2 polypeptides and nucleic acid molecules..
Acorda Therapeutics, Inc.
Vegf analogs and methods of use
Modified vegf proteins that inhibit vegf-mediated activation or proliferation of endothelial cells are disclosed. The analogs may be used to inhibit vegf-mediated activation of endothelial cells in angiogenesis-associated diseases such as cancer, inflammatory diseases, eye diseases, and skin disorders..