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|| List of recent Proliferation-related patents
| Method and device for preparing non-embryonic stem cells|
The invention relates to a process for preparing a non-expanded tissue derivative, that is not subjected to cell proliferation in vitro, which has a vascular-stromal fraction enriched in stem and multipotent elements, such as pericytes and/or mesenchymal stem cells, or for preparing non-embryonic stem cells obtained from a tissue sample or from such tissue derivative, wherein the tissue derivative or such cells are subjected to vibrations derived from a heart sound to control the degree of differentiation or possible differentiation of the stem and multipotent elements into several other types of cells and optimize their potency. The invention relates also to a device for carrying out the process, to stem cells obtainable by the process as well as a drug for the regeneration of an animal tissue..
Lipogems International Srl
| Cell culture|
The disclosure relates to the fabrication of a three dimensional [3-d] cell culture membrane comprising one or more functionalized surfaces adapted to provide cell culture conditions suitable for the analysis of proliferation, differentiation or function of cells, typically eukaryotic or prokaryotic cells.. .
Centre National De La Recherche Scientifique
| Monoclonal antibody against human midkine|
A monoclonal antibody, which recognizes at least two amino acids among amino acids located at position 69, position 79, position 81 and position 102 of human midkine, has been found to have excellent reactivity with and excellent neutralizing activity against human midkine. Moreover, the activity of suppressing the proliferation of tumor has been observed in the antibody having excellent neutralizing activity.
National University Corporation Nagoya University
| Compositions and methods of using islet neogenesis peptides and analogs thereof|
The invention provides peptides and analogs of ingap and hip peptides. The peptides and analogs can be used in methods for treating various diseases and conditions.
Shenzhen Hightide Biopharmaceutical, Ltd.
| Novel 19-nor-steroids and their use for treating progesterone- dependent conditions|
The subject matter of the instant invention is pertinent to the field of treatment of hormone-dependent conditions. New compounds and methods for treating these conditions are disclosed.
Repros Therapeutics Inc.
| Use of psoralen derivatives and combination therapy for treatment of cell proliferation disorders|
Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a dna cross-linking motif to cancer cells, applying a psoralen or a derivative thereof and lapatinib, or applying a psoralen or derivative thereof and neratinib, to a subject and further applying initiation radiation energy form an energy source.. .
| Medicament for wound treatment|
The invention relates to stathmin, stathmin, a nucleic acid encoding said stathmin or a cell expressing stathmin for use in the treatment of chronic wounds or disease- or medication-dependent impaired wound healing in a patient or for increasing or inducing the proliferation and/or migration of mesenchymal cells, of stem cells, for stimulating immune cells, preferably natural killer cells, for stimulating fibroblasts, for stimulating epithelial cells, preferably epithelial cells of the epidermis, or for stimulating angiogenesis.. .
Simu Trade Consulting Gmbh & Co. Leasing Kg
| Differentiation marker and differentiation control of eye cell|
The present invention relates to a differentiation marker and a differentiation controlling technique for an eye cell. More particularly, the present invention has attained an object of providing a differentiation marker for an eye cell among the aforementioned problems, by providing a marker for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, the marker comprising gpr49/lgr5, as well as a detection agent or detection method for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, comprising a substance binding to gpr49/lgr5.
| Method for treating triple-negative breast cancer using ampi-109|
A targeted approach toward the treatment of tn breast cancer by using ampi-109 is disclosed. Ampi-109 is a compound with remarkable “cancer-specific” characteristics.
The Regents Of The University Of Colorado
|Stack light with modular power converter|
A power converter is introduced into a stack light in the form of a compatible modular element that fits between the base and a light module. By converting multiple input voltages to a common core voltage in a module distinct from the base and light modules, proliferation of different varieties of base modules and light modules may be reduced without impact on customer selection..
Rockwell Automation Technologies, Inc.
Compositions and uses to govern cancer cell growth
The invention relates to composition and a method of using the composition for modulting proliferation, invasiveness, the expression of a biomarker of an abnormal cell, of reducing the risk of patient cell becoming abnormal, or of modulating proliferation of a carcinoma-associated fibroblast or of a tumor-associated macrophage. The invention also relates to a method of culturing the composition to produce molecules that modulate abnormal cell proliferation, invasiveness, or metastasis.
Massachusetts Institute Of Technology
Human cd8+ regulatory t cells inhibit gvhd and preserve general immunity in humanized mice
Graft-versus-host disease (gvhd) is a lethal complication of allograft transplantation. The current strategy of using immunosuppressive agents to control gvhd may cause general immune suppression and limit the effectiveness of allograft transplantation.
The University Of Hong Kong
Method of treating microbial infections
Methods of inhibiting or preventing the proliferation of a fungus and/or a bacteria in a living organism, in water, in air, and/or on surfaces, include administering or providing a therapeutic amount or an effective amount of an antimicrobial composition including octodrine.. .
Keck Graduate Institute Of Applied Life Sciences
Human serum albumin linkers and conjugates thereof
Disclosed is a human serum albumin (hsa) linker and hsa linker with binding, diagnostic, and therapeutic agents conjugated thereto. Also disclosed is a conjugate in which the hsa linker is covalently bonded to amino and carboxy terminal binding moieties that are first and second single-chain fv molecules (scfvs).
Merrimack Pharmaceuticals, Inc.
Acyl-hydrazone and oxadiazole compounds, pharmaceutical compositions containing the same and uses thereof
The present invention relates to acyl-hydrazone compounds, in particular 3,4,5-trimethoxyphenyl-hydrazide derivatives, as well as the oxadiazole analogs thereof and other similar compounds, and to the pharmaceutical use of the same for the treatment of various diseases associated with cell proliferation, such as leukemias, including acute lymphoblastic leukemia (all), tumours and inflammation. Acyl-hydrazones have been obtained having activity similar to that of the compound used as a standard in experiments (colchicine).
Universidade Federal De Santa Catarina
Drugs with improved hydrophobicity for incorporation in medical devices
The invention provides a medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The invention also provides a method of treating a narrowing in a body passageway comprising placing an implantable medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration.
Abraxis Bioscience, Llc
Coated devices and methods of making coated devices that reduce smooth muscle cell proliferation and platelet activity
The present invention relates generally to the maintenance of blow flood using drug eluting stents and/or other coated medical devices to increased length of time of blood flow. Further, the present invention relates to drug-releasing coated devices for reducing smooth muscle cell proliferation and platelet activity to further limit restenosis utilizing resveratrol and quercetin, polyphenols that are linked to the cardioprotection of red wine consumption.
Dynamic montioring of g-protein coupled receptor (gpcr) and receptor tyrosine kinase (rtk) activity and pathways in living cells using real-time microelectronic cell sensing technology
Use of cell-substrate impedance based methods for screening for agonists of g-protein coupled receptors (gpcrs) or inhibitors of a receptor tyrosine kinases (rtks), identifying compounds that affect gpcr or rtk pathways, validating molecular targets involved in a gpcr or rtk signaling pathways, monitoring dose-dependent functional activation of gpcr or rtk; determining desensitization of a gpcr and identifying a compound capable of affecting rtk activity in cancer cell proliferation.. .
Acea Biosciences, Inc.
Translocation and mutant ros kinase in human non-small cell lung carcinoma
In accordance with the invention, a novel gene translocation, (4p15, 6q22), in human non-small cell lung carcinoma (nsclc) that results in a fusion proteins combining part of sodium-dependent phosphate transporter isoform napi-3b protein (slc34a2) with proto-oncogene tyrosine protein kinase ros precursor (ros) kinase has now been identified. The slc34a2-ros fusion protein is anticipated to drive the proliferation and survival of a subgroup of nsclc tumors.
Cell Signaling Technology, Inc.
Regimens for treatments using anti-igf antibodies
Without limitation, this disclosure relates to methods of treating cell proliferation disorders, neoplastic disorders, cancers, tumors and the like using anti-igf antibodies, or antigen binding fragments thereof. Disclosed herein are methods of treating cancer in a patient, for example a human patient, comprising administering to the patient at least two doses of an antibody which binds both igf-i and/or igf-ii.
Use of pedf-derived polypeptides for promoting stem cells proliferation and wound healing
Disclosed herein is a synthetic peptide, which has an amino acid sequence that has 20-39 amino acid residues. The synthetic peptide has at least 80% amino acid sequence identity to seq id no: 1, and includes at least 20 consecutive residues that has at least 90% amino acid sequence identity to residues 11-30 of seq id no: 1.
Mackay Memorial Hospital
Pyrimidine compound and medical use thereof
Wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like.
Heteroaryl compounds useful as inhibitors of e1 activating enzymes
This invention relates to compounds that inhibit e1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia..
Millennium Pharmaceuticals, Inc.
Compositions and methods for enhancing mobilization and proliferation of blastomere-like stem cells
The present invention provides a method of using mobilization agents to enhance stem cell trafficking in a subject, including very small embryonic-like (vsel) stem cells. In one embodiment, a blended composition of algae, fruits, mushrooms, microorganisms, maternal fluids, and extracts thereof are used to promote trafficking of stem cells, resulting in migration of the stem cells to specific sites of maintenance and repair within tissues and/or organs..
Stemtech International, Inc.
Compositions and methods of treating cell proliferation disorders
The invention relates to compounds and methods for treating cell proliferation disorders.. .
Kinex Pharmaceuticals, Inc.
Pyrido[2,3-b]pyrazin-8-substituted compounds and their use
The present invention pertains generally to the field of therapeutic compounds for treating proliferative disorders, cancer, etc., and more specifically to certain pyrido[2,3-b]pyrazin-8-substituted compounds, as described herein, which, inter alia, inhibit raf (e.g., b-raf) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit raf (e.g., braf) activity, to inhibit receptor tyrosine kinase (rtk) activity, to inhibit cell proliferation, and in the treatment of diseases and disorders that are ameliorated by the inhibition of raf, rtk, etc., proliferative disorders such as cancer (e.g., colorectal cancer, melanoma), etc..
Cancer Research Technology Limited
Recombinant alsv for preventing pathogenic viral infection of plant
The invention provides a recombinant apple latent spherical virus (alsv). The recombinant alsv contains a partial fragment of a genomic rna or cdna from one or more plant pathogenic viruses, and manifests an interference effect against these plant pathogenic viruses.
Use of sirt7 as novel cancer therapy target and treating cancer using the same
The present invention relates to the use of sirt7 (sirtuin 7) as a marker for diagnosis of liver cancer. More specifically, the invention relates to a liver cancer diagnostic marker comprising sirt7 gene, a liver cancer diagnostic composition, kit and microarray comprising the same, and a method of diagnosing liver cancer using the same.
Catholic University Industry Academic
Replication competent pseudo-type retrovirus vector system
The present invention provides a vector system in which a mulv-gag gene, a mulv-pol gene, and a galv-env gene are expressed in two separate vectors. The vector system is capable of inserting a therapeutic gene to these two separate vectors, and in this raged, the size of an inserted gene is not limited and a variety of foreign therapeutic genes may be inserted to the vectors.
Inje University Industry-academic Cooperation Foundation
Three dimensional matrix for cancer stem cells
Synthetic inert 3d gel culture systems are described that can be finely tuned to exhibit desired and predetermined physical, chemical, mechanical, and biochemical properties. The culture system can be utilized to study the effect of microenvironmental factors on cancer cell response, and in particular on cancer stem cell (csc) response.
University Of South Carolina
System and method to facilitate the growth of stem cells
A method and system to maintain adult or embryonic stem cells employing 3-d culture conditions is disclosed. Hydrogel scaffolds, composed of hydrophilic polymer networks are provided to emulate a fully hydrated native extracellular matrix and natural soft tissue.
Methods and compositions for modulating beta cell proliferation
Methods and compositions are provided for modulating pancreatic islet β cell proliferation. Aspects of the methods include promoting β cell proliferation by providing agents that promote pdgfr signaling, or inhibiting β cell proliferation by providing agents that inhibit pdgfr signaling.
The Board Of Trustees Of The Leland Stanford Junior University
Compositions including triciribine and methods of use thereof
This invention encompasses combination therapies including tcn, tcn-p, tcn-pm and/or related compounds and one or more additional anti-cancer agents, for example, taxanes a molecule that modulates the her2/neu (erbb2) receptor, anthracyclin compounds, epidermal growth factor receptor inhibitor compounds, one or more platinum compounds and bortezomib and derivatives thereof and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. .
University Of South Florida
The present invention relates to a pharmaceutical combination which may be useful for the treatment of diseases which involve cell proliferation, which involve migration or apoptosis of myeloma cells, which involve angiogenesis or which involve fibrosis. The invention also relates to a method for the treatment of said diseases, comprising simultaneous, separate or sequential administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations..
Boehringer Ingelheim International Gmbh
Substituted dialkyl(oxido)-lambda4-sulfanylidene nicotinamide derivatives as kinase inhibitors
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.. .
Substituted nicotinamide derivatives as kinase inhibitors
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.. .
Smoothened modulators and methods of use thereof
Compounds of general formulas (i), (ia), (ib) are described, along with compositions containing the same and methods of use thereof, inhibiting the hedgehog pathway in a cell or inhibiting unwanted proliferation of a cell.. .
Compositions useful as antibiofilm or antimicrobial agents and methods using same
The present invention includes compositions and methods useful for removing microorganisms and/or biofilm-embedded microorganisms from the surface of a medical device or subject's body. The present invention further includes compositions and methods useful for coating medical devices.
Baylor College Of Medicine
Wnt signaling inhibitor comprising insulin-like growth factor-binding protein
Provided is a novel soluble factor that modulates morphogenesis and cell proliferation, such as cardiac development and/or cardiomyocyte differentiation. Specifically provided are: an inhibitor of wnt signalling, comprising an insulin-like growth-factor-binding protein (igfbp), the protein being binding to a wnt receptor, and/or a polynucleotide encoding the protein; a medicament for prevention and/or treatment of a disease due to enhanced wnt signalling, comprising the inhibitor of wnt signalling, and a medicament for induction of cardiomyocyte differentiation; and a method for prevention and/or treatment of a disease due to enhanced wnt signalling and a method of inducing cardiomyocyte differentiation, the methods each comprising using the inhibitor of wnt signalling, and a cardiomyocyte, which is obtained by the method of inducing cardiomyocyte differentiation, and a use thereof..
National University Corporation Chiba University
Chondrocyte proliferation promoting agent
The present invention provides a novel active ingredient which can be safely used in preventing, ameliorating or treating diseases related to the cartilage such as cartilage damages and cartilage disorders. Since the egg yolk protein hydrolyzate has an effect on chondrocyte proliferation promotion, it is useful as an active ingredient for preventing, ameliorating or treating cartilage disorders and for preventing, ameliorating or treating joint pain.
Pharma Foods International Co., Ltd.
Treatment for chitin-containing microorganisms
The present disclosure relates to treatment of chitin-containing microorganism infection or colonization on an aquatic animal. The methods, systems, and kits provided herein facilitate termination and/or inhibition of proliferation of chitin-containing microorganisms (e.g., saprolegnia and sea lice)..
Benchmark Animal Health Limited
Novel low-molecular-compound for improving production, maintenance and proliferation of pluripotent stem cells, composition comprising the same, and culture method
According to the present invention, when the novel low-molecular-weight compound rsc-133 is added in a culture process for producing reprogrammed pluripotent stem cells from human differentiated cells, it can increase the efficiency of reprogramming and can significantly reduce the time required for the induction of reprogramming. Particularly, the novel compound rsc-133 can substitute for c-myc acting as both a reprogramming factor and an oncogenic factor, and it can effectively increase the efficiency of reprogramming in both normal oxygen culture conditions and hypoxic culture conditions.
Korea Reasearch Institute Of Bioscience And Biotechnology
Method for preparing endocrine aggregate of insulin-producing beta cells from human pluripotent stem cells
The present invention prepared insulin-producing endocrine cells by inducing the differentiation of human embryonic stem cells or human induced pluripotent stem cells into definitive endoderm (de), pancreatic endoderm (pe), endocrine progenitors (ep), and endocrine cells (ec) stepwise in that order. Particularly, the present invention established the conditions for the formation of an insulin producing endocrine aggregate (ea) from the endocrine cells.
Korea Advanced Institute Of Science And Technology
Adjuvant for rapid proliferation of human mesenchymal stem cells in vitro, rapid proliferation of human mesenchymal stem cells in vitro, growth factor harvested from rapid proliferation of human mesenchymal stem cells in vitro and use thereof
An adjuvant for rapid proliferation of human mesenchymal stem cells in vitro is provided to overcome the problem of low cell amplification efficiency of human mesenchymal stem cells in a culture process. The adjuvant added for the culture of human mesenchymal stem cells includes at least one antioxidant, and a basic fibroblast growth factor (fgf-2).
Buddhist Tzu Chi Medical Foundation
Methods and compositions for regulating musashi function
The invention generally features compositions and methods for detecting and regulating cell proliferation, potentiation, and differentiation in a population of cells. In particular, compositions and methods are provided for modulating the activity of musashi proteins.
Board Of Trustees Of The University Of Arkansas
The present invention relates to a gremlin-1 antibody that inhibits gremlin-1 in a manner independent of bone morphogenetic protein (bmp) or vascular endothelial growth factor receptor-2 (vegfr-2), thus providing the effect of treating cancer. The antibody of the present invention inhibits cell migration, cell invasion and cell proliferation which are dependent on gremlin-1, and therefore, can be effectively used in treating cancer or immune disease..
Snu R&db Foundation
Novel bioactive protein isolated from chinese yam and uses thereof
A protein isolated from the chinese yam dioscorea opposita that stimulates estrogen and progesterone release in vitro and in vivo but does not stimulate the proliferation of breast and ovarian cancer cells is disclosed. The protein exhibits anti-osteoporotic activity in vivo.
The University Of Hong Kong
Cytochrome p450 inhibitors and uses thereof
And pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis and proliferation, and where anti-fibrotic or anti-proliferative activity is beneficial.. .
Papillomavirus pseudoviruses for detection and therapy of tumors
Disclosed herein are methods of detecting tumors, monitoring cancer therapy, and selectively inhibiting the proliferation and/or killing of cancer cells utilizing a papilloma pseudovirus or a papilloma virus-like particle (vlp). .
The Usa, As Represented By The Secretary, Dept. Of Health And Human Services
Compounds that enhance atoh1 expression
This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an atoh1 gene (e.g., hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation..
The Brigham & Women's Hospital, Inc.
Inhibitors of hippo-yap signaling pathway
This invention provides methods of preventing, reducing, delaying or inhibiting the proliferation, growth, migration and/or metastasis of cancer by administering an effective amount of an inhibitor of the hippo-yap signaling pathway.. .
The Regents Of The University Of California
Non-invasive measuring proliferation and differentiation state of cells by using magnetic resonance spectroscopy, and cell proliferation and differentiation marker for magnetic resonance spectroscopy used therefor
Provided are a noninvasive measurement of cell signals and a method thereof, wherein the measurement method can ascertain cell proliferation and differentiation states using mrs and can enable cells to be reused so that cell states can be evaluated with improved reproducibility and reliability. And since the cell signals are noninvasively measured using the mrs, the corresponding cells can be reused so that the cost and time needed for one experiment can be remarkably reduced..
Inje University Industry-academic Cooperation Foundation
Mirnas as therapeutic targets in cancer
Micrornas (mirnas) are a class of non-coding small rna molecules that regulate gene expression at the post-transcriptional level by interacting with 3′ untranslated regions (utrs) of their target mrnas. The invention relates to the application of mir-192 and mir-215.
The Research Foundation For The State University Of New York
Uses of kappa opioid synthetic peptide amides
The invention relates to methods of use of synthetic peptide amides that are ligands of the kappa opioid receptor in the treatment and prevention of kappa opioid receptor-associated diseases and conditions; and particularly to uses of these agonists in the prophylaxis, inhibition and treatment of pain, inflammation and pruritis associated with a variety of diseases, disorders and conditions. Inflammatory conditions preventable or treatable by the methods of the invention include diseases and conditions associated with elevated levels of a proinflammatory cytokines, such as tnf-α, il-1β, il-6, mmp-1 and mmp-3.
Cara Therapeutics, Inc.
Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the wnt pathway and/or of one or more of wnt signaling components.
Compounds of the formula (i) in which r, r1, r2 and r3 have the meanings indicated in claim 1, are inhibitors of pdk1 and cell proliferation/cell vitality and can be employed for the treatment of tumours.. .
Merck Patent Gmbh
3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
Or a pharmaceutically acceptable salt thereof, wherein r1, r2a, r2b and r3-r7 are herein. The invention is also directed to compositions containing a compound of formula (i) and to the use of such compounds in the inhibition of mutant idh proteins having a neomorphic activity.
Materials and methods useful to induce vacuolization, cell death, or a combination thereof
The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer.
The University Of Toledo
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Proliferation topics: Proliferation, Cell Proliferation, Differentiation, Cancer Cell, Antibodies, Progesterone, Specificity, Cancer Cells, Antimicrobial, Lymphocyte, Cell Differentiation, Homogeneous, Amino Acids, Wound Healing, Epithelial
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