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Proliferation patents



      
           
This page is updated frequently with new Proliferation-related patent applications. Subscribe to the Proliferation RSS feed to automatically get the update: related Proliferation RSS feeds. RSS updates for this page: Proliferation RSS RSS


Date/App# patent app List of recent Proliferation-related patents
05/28/15
20150148401
 Methods and compositions for inhibiting the growth and/or proliferation of myc-driven tumor cells patent thumbnailnew patent Methods and compositions for inhibiting the growth and/or proliferation of myc-driven tumor cells
The invention generally relates to methods for identifying and using anticancer therapeutic agents and, more particularly, to methods for identifying and using inhibitors of genes for inhibiting the growth and/or proliferation of myc-driven tumor cells relative to normal cells.. .
Fred Huchinson Cancer Research Center
05/28/15
20150148383
 Methods for inhibiting or reversing epiretinal membrane formation patent thumbnailnew patent Methods for inhibiting or reversing epiretinal membrane formation
Described herein are treatment methods involving the administration of nicotinamide, which has been discovered to stabilize the normal phenotype of retinal pigment epithelial cells and to prevent retinal pigment epithelial cell proliferation. Diseases and disorders that can be treated according to the methods disclosed herein include, e.g., macular pucker, proliferative vitreoretinopathy, preretinal fibrosis, vitreomacular traction, tractional retinal detachment, and phthsis bulbi, cystoid macular edema (cme) arising from intraocular inflammation due to uveitis, vasculitis, trauma, surgery, and collagen vascular disease (e.g., behcets disease or sarcoidosis), and age related macular degeneration..
Regenerative Research Foundation
05/28/15
20150148356
 Compounds for dry skin and anti-ageing application patent thumbnailnew patent Compounds for dry skin and anti-ageing application
The present invention relates to the cosmetic use, as agent for preventing and/or treating an aesthetic defect in the skin and/or its appendages that is associated with an imbalance in the differentiation and/or proliferation of the cells of an epidermis, of an effective amount of at least one compound represented by one of the general formulae, (ia) or (ib). .
L'oreal
05/28/15
20150147807
 High-throughput image-based chemical screening in zebrafish blastomere cell culture patent thumbnailnew patent High-throughput image-based chemical screening in zebrafish blastomere cell culture
Disclosed are methods of inducing differentiation of stem into myogenic cells without gene manipulation and for inducing proliferation of satellite cells. The cells can be used as a source of cells for transplantation in a subject in need thereof.
Children's Medical Center Corporation
05/28/15
20150147417
 Method and pharmaceutical composition for liver fibrosis prevention and/or treatment patent thumbnailnew patent Method and pharmaceutical composition for liver fibrosis prevention and/or treatment
The present invention is related to a method for liver fibrosis prevention and/or treatment and a pharmaceutical composition thereof. The method and the pharmaceutical composition are made by taking the advantage of blumea lacera ‘efficacy in accumulating lipid in hepatic stellate cells, down-regulating the proliferation of hepatic stellate cells, inhibiting the mobility of hepatic stellate cells, preventing the activation of hepatic stellate cells, and decreasing the synthesis of ecm proteins.
National Dong Hua University
05/21/15
20150143562
 Non-human animals having a humanized a proliferation-inducing ligand gene patent thumbnailNon-human animals having a humanized a proliferation-inducing ligand gene
Non-human animals, cells, methods and compositions for making and using the same are provided, wherein the non-human animals and cells comprise a humanized a proliferation-inducing ligand gene. Non-human animals and cells that express a human or humanized a proliferation-inducing ligand protein from an endogenous a proliferation-inducing ligand locus are described..
Regeneron Pharmaceuticals, Inc.
05/21/15
20150143559
 Non-human animals having a humanized a proliferation-inducing ligand gene patent thumbnailNon-human animals having a humanized a proliferation-inducing ligand gene
Non-human animals, cells, methods and compositions for making and using the same are provided, wherein the non-human animals and cells comprise a humanized a proliferation-inducing ligand gene. Non-human animals and cells that express a human or humanized a proliferation-inducing ligand protein from an endogenous a proliferation-inducing ligand locus are described..
Regeneron Pharmaceuticals, Inc.
05/21/15
20150143557
 Composition for inducing proliferation or accumulation of regulatory t cells patent thumbnailComposition for inducing proliferation or accumulation of regulatory t cells
It was found that bacteria belonging to the genus clostridium induce accumulation of regulatory t cells (treg cells) in the colon. Moreover, the present inventors found that regulatory t cells (treg cells) induced by from these bacteria suppressed proliferation of effector t-cells.
The University Of Tokyo
05/21/15
20150143539
 Method and system for backing up and restoring license patent thumbnailMethod and system for backing up and restoring license
A method for backing up and restoring a license is provided, which solves the problem of right proliferation in the prior art caused when an original license is transmitted to a user when a server restores the license. The method includes: backing up, at a server, license information of a first device, and associating the license information with a user identifier, the license information reflecting the current state information of a license when the first device reports the license information the last time; requesting, by a second device, the server to restore the license; and validating, by the server, a user identifier of the second device and the user identifier associated with the license information, and upon determination that the two user identifiers are consistent, generating a license based on the license information backed up, and transmitting the license to the second device.
Huawei Technologies Co., Ltd.
05/21/15
20150141735
 Method and device for the desctruction of cells with uncontrolled proliferation patent thumbnailMethod and device for the desctruction of cells with uncontrolled proliferation
The present invention relates to a method and device for the selective destruction of cells that with uncontrolled proliferation in an animal organism, with minimum damage to the surrounding tissue thereby and without needing to perform any kind of surgical operation on the patient: the method consists of the detection of the tumorous area (1) and the sequential and alternate application of at least two alternating magnetic fields with different directions to the treatment area or application until achieving the heating and destruction of the cells. The device used is, therefore, comprised of at least two electromagnets (11, 12) or at least two pairs of electromagnets (11-11′, 12-12′) all being located around the perimeter of a hypothetical circumference or sphere, with the electromagnets in opposing pairs where each opposing pair generates an electromagnetic field in one direction and orientation..
Investigaciones, Desarrollos Innovaciones Tat Iberica, S.l.
05/21/15
20150141660

Substrates and inhibitors of antiplasmin cleaving enzyme and fibroblast activation protein and methods of use


The presently disclosed and claimed inventive concepts include inhibitors of antiplasmin cleaving enzyme (apce) and fibroblast activation protein alpha (fap) which can be used in various therapies related to disorders of fibrin and α2-antiplasmin and abnormal cell proliferation. The presently disclosed and claimed inventive concepts also include substrates of apce and fap, which may be used, for example, in screening methods for identifying such inhibitors.
The Board Of Regents Of The University Of Oklahoma
05/21/15
20150141523

Compounds for use in the treatment of autoimmune inflammatory disease


And salts thereof is useful in the prophylaxis or treatment of inflammatory bowel disease or other inflammatory autoimmune diseases with similar aetiology involving t-cell proliferation or or function.. .
05/21/15
20150141463

Substituted pyrazolone compounds and methods of use


The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans..
Sunshine Lake Pharma Co., Ltd.
05/21/15
20150141430

Method for modulating canonical wnt pathway using folate and inositol


The canonical wnt signaling pathway is implicated in wound healing. Administration of a composition having myo-inositol and folic acid upregulates fibronectin and provides the greatest protection in an additive/synergistic manner against adverse wnt/β-catenin-mediated effects on cell processes relating to cell differentiation, proliferation, and migration that relate to wound healing..
University Of South Florida
05/21/15
20150141364

Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof


This application relates to combination therapies including triciribine compounds and epidermal growth factor receptor inhibitor compounds, particularly erlotinib-like compounds and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. .
University Of South Florida
05/21/15
20150141346

Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof


This application relates to combination therapies including triciribine and related compounds and bortezomib and derivatives thereof analogs and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. .
University Of South Florida
05/21/15
20150140633

System and proliferation of stem cells in cellular tissue


A method and a system are provided for subjecting organic cells in a region of a subject to an extremely low frequency magnetic field. At least one resonance medium is operably connected to a generator.
05/21/15
20150140594

Human taste cells capable of continuous proliferation


The present invention relates to proliferating human taste cells, wherein the cells are the cells deposited under the dsmz deposit accession number dsm acc3169 or taste cells derived thereof. The present invention further relates to the proliferating human taste cells of the invention for use in research.
B.r.a.i.n. Biotechnology Research And Information Network Ag
05/21/15
20150140124

Method of diagnosing, treating and determining progression and survival of cancer cells using bcl-2 antagonist of cell death (bad) pathway gene signature


The present invention relates to the bad pathway's influence on development, progression, chemo-sensitivity, and overall survival for multiple human cancers and its potential as a therapeutic target to increase chemo-sensitivity. Bad pathway expression was associated with the development and/or progression of breast, colon, and endometrial cancers, relapse-free survival from breast cancer, and overall survival from ovarian, colon, and brain cancers.
H. Lee Moffitt Cancer Center And Research Institute, Inc.
05/21/15
20150140123

Protein expression analyses for identifying genotoxic compounds


The invention relates to a method for screening compounds with (pro-)genotoxic activity by providing a system being capable of expressing a panel of defined proteins, incubating at least a portion of the system with compounds to be screened, and comparing the expression of the proteins in the system with the protein expression in a control system, thereby detecting the (pro-)genotoxic activity. Another object of the invention concerns a method for monitoring the likelihood of developing a physiological and/or pathological condition, which is caused, mediated and/or propagated by the genetic deregulation of proliferation, differentiation and/or damage repair, in response to a compound administered to a mammal in need of such treatment by determining an expression level of defined proteins in a biological sample withdrawn from the mammal.
Merck Patent Gmbh
05/21/15
20150140029

Extracts from fusarium oxysporums and use thereof


Disclosed are the action and use of water extracts and polysaccharides from fusarium oxysporums in immune enhancement, which belong to the field of biological pharmacy. The water extracts and polysaccharides from fusarium oxysporums have a significant immune enhancement effect, which can promote the proliferation of macrophages, increase the phagocytic ability of macrophages, activate macrophages to release immunological active factors no, il-1α and tnf-α and can be used in lower immune function diseases and tumor adjuvant treatment..
University Of Macau, Av. Padre Tomas Pereira Taipa
05/21/15
20150140013

Modulation of asymmetric proliferation


Provided herein are methods and compositions related to modulation of the rate of asymmetric proliferation of cancer cells. In some embodiments, the methods described herein relate to the treatment of cancer, at least in part, via the modulation of the rate of asymmetric proliferation of cancer cells..
The General Hospital Corporation
05/21/15
20150139989

Antibody recognizing human leukemia inhibitory factor (lif) and use of anti-lif antibodies in the treatment of diseases associated with unwanted cell proliferation


The invention relates to antibodies directed against human leukemia inhibitory factor (lif) and to a hybridoma cell line producing said antibodies. The invention also relates to a method for blocking/inhibiting the proliferation of stem cells, and to an in vitro method for the diagnosis of diseases associated with unwanted cell proliferation in a subject or for determining the predisposition of a subject to suffer from said disease associated with unwanted cell proliferation, or for prognosis of average life expectancy of a subject suffering from said disease.
Fundacio Privada Institucio Catalana De Recerca I Estudis Avancats (icrea)
05/21/15
20150139955

Agent for promoting proliferation of bifidobacteria


A peptide dimer comprising a peptide consisting of the amino acid sequence of seq id no: 1 and a peptide consisting of any one of the amino acid sequences of seq id nos: 2 to 4, wherein the peptide consisting of the amino acid sequence of seq id no: 1 and the peptide consisting of any one of the amino acid sequences of seq id nos: 2 to 4 are bound through a disulfide bond between a cysteine residue of each peptide is used as an active ingredient of an agent for promoting proliferation of one or more bacterium selected from the group consisting of bifidobacterium infantis and bifidobacterium breve.. .
Morinaga Milk Industry Co., Ltd.
05/21/15
20150139951

Engineered antibody-interferon mutant fusion molecules


The field of the present invention relates to genetically engineered fusion molecules, methods of making said fusion molecules, and uses thereof in anti-tumor immunotherapies. More specifically, the present invention relates to fusion molecule constructs wherein a tumor associated antigen (taa) antibody (ab) serves as a targeting moiety to selectively deliver a cytokine to a tumor cell for purposes of killing or inhibiting the growth or proliferation of said tumor cell.
Immungene Inc.
05/14/15
20150133832

At-home light-emitting diode and massage device for vaginal rejuvenation


A light emitting module and massage device provide vaginal rejuvenation. The device exposes collagen in the vaginal area or mucosa to temperatures elevated over normal body temperature to cause the collagen to reversibly or irreversibly denature while simultaneously applying vibration.
05/14/15
20150133462

Methods and compositions for the treatment of bcr-abl positive lymphoblastic leukemias


In one aspect, the invention relates to compositions comprising bcr-abl tyrosine kinase inhibitors and artemisinin analogues, derivatives thereof, or related compounds, which are useful as in treating philadelphia chromosome positive leukemias; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with bcr-abl dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention..
05/14/15
20150133460

Lactate salt of 4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)quinazolin-4-yl]piperazine-1-carboxylic acid(4-isopropoxyphenyl)-amide and pharmaceutical compositions thereof for the treatment of cancer and other diseases or disorders


Or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; processes for the synthesis or manufacture of the compound of formula (i), or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; and the use of said compound, or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof, for the treatment of patients suffering from or subject to diseases, disorders or conditions involving cell survival, proliferation, and migration, including cardiovascular disease (e.g., arteriosclerosis and vascular reobstruction), cancer, (e.g., aml and malignant glioma) glomerulosclerosis, fibrotic disease and inflammation.. .
05/14/15
20150133457

Heterocyclic compounds and uses thereof


The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, egfr (including her), alk, pdgfr, blk, bmx/etk, flt3(d835y), itk, tec, txk, btk, or jak, and the respective pathways.. .
05/14/15
20150133447

Triazolopyrazine


Wherein the groups r1 to r3, x3 to x6 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament..
05/14/15
20150133420

Broad antiviral therapy with membrane modifying oxysterols


This invention relates, e.g., to a method for inhibiting the growth and/or proliferation and/or infectivity of a virus in a cell, such as a mammalian cell (e.g. For inhibiting entry of the virus into the cell), comprising administering, or causing to be administered, to the cell, 25-hydroxycholesterol (25hc) in an amount sufficient to inhibit the growth and/or proliferation and/or infectivity of the virus in the cell.
05/14/15
20150133399

Composition and uses of galectin antagonist


The present invention is directed to methods and compositions for augmenting treatment of cancers and other proliferative disorders. In particular embodiments, the invention combines the administration of an agent that inhibits the anti-apoptotic activity of galectin-3 (e.g., a “galectin-3 inhibitor”) so as to potentiate the toxicity of a chemotherapeutic agent.
05/14/15
20150133380

Methods for treating diseases with peptides that inhibit igf-1


The invention relates to peptides useful for inhibiting igf-1 activity and their use as agents for inhibition of in vitro cell proliferation and for treatment of various diseases.. .
05/14/15
20150132770

Pregnancy-associated plasma protein-a2 (papp-a2) polynucleotides


The present invention provides pregnancy associated plasma protein a2 (papp-a2), its nucleotide and amino acid sequences, antisense molecules to the nucleotide sequences which encode papp-a2, expression vectors for the production of purified papp-a2, antibodies capable of binding specifically to papp-a2, hybridization probes or oligonucleotides for the detection of papp-a2-encoding nucleotide sequences, genetically engineered host cells for the expression of papp-a2, and methods for screening for pathologies in pregnant and non-pregnant patients. Methods for screening for altered focal proliferation states in pregnant and/or non-pregnant patients, which include detecting levels of papp-a2, are also described..
05/07/15
20150126583

Reducing galectin-12 activity to influence the cell function of human sebocytes


Methods for the treatment of a disorder characterized by excessive proliferation and/or lipid content of sebocytes are disclosed. In one embodiment of the invention, the method comprises administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a small molecule inhibitor targeted to galectin-12 or a nucleic acid-based inhibitor targeted to galectin-12 and a pharmaceutically acceptable carrier, wherein said inhibitor is a non-naturally occurring molecule and administration of said inhibitor produces a decrease in the proliferation and/or lipid content of the sebocytes.
Academia Sinica
05/07/15
20150126581

Micrornas and uses thereof


Provided herein are methods for inhibiting expression of dohh in a cell, and for inhibiting hypusination of eif5a in a cell, the methods comprising contacting a cell with a mirna or a nucleic acid molecule encoding the mirna, wherein the mirna binds to the 3′utr of the dohh mrna and wherein binding results in a reduction in dohh expression. Also provided are methods for reducing cellular proliferation and for treating diseases associated with abnormal cellular proliferation..
The University Of Western Australia
05/07/15
20150126518

Biguanide compounds and use thereof


The present invention relates to biguanide compounds and use thereof, more particularly, to biguanide derivatives exhibiting excellent effects for inhibition of cancer cell proliferation and inhibition of cancer metastasis and recurrence, a method for preparing the same, a pharmaceutical composition containing the same as an active ingredient, and a method of prevention or treatment of cancer comprising the step of administering an effective amount of the composition to a subject in need thereof.. .
Hanall Biopharma Co., Ltd.
05/07/15
20150126507

Compounds to treat hearing loss


To treat or prevent hearing loss. Compounds of the present invention also promote sensory hair cell regeneration.
04/30/15
20150121453

System and new database permitting


The design and implementation of databases within enterprises is a crucial process, but is often resource intensive and often times unnecessary as existing databases may be utilized to serve the same goals. Tracking existing databases and assessing the design specifications of proposed databases is a complex decision making process.
Metropolitan Life Insurance Co.
04/30/15
20150119585

Sterol derivative


The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (i) (wherein y represents optionally substituted lower alkyl or the like; xa and xb are the same or different, and represent a bond or the like; r1, r2, r3, r4, r7 and r8 are the same or different, and represent a hydrogen atom or the like; r5 and r6 are the same or different, and represent a hydrogen atom or the like; r9 represents a hydrogen atom or the like; r10 and r11 together represent a bond or the like; and r12 represents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof..
Kyowa Hakko Kirin Co., Ltd
04/30/15
20150119413

Treatment of polycystic diseases with an hdac6 inhibitor


An hdac6-specific inhibitor (i.e., a compound of formula i or ii) is shown to reduce the pathogenesis associated with polycystic disease. Administration of an hdac6-specific inhibitor attenuated many of the symptoms characteristic of polycystic liver disease including cyst formation, cyst growth and cholangiocyte proliferation.
Mayo Foundation For Medical Education And Research
04/30/15
20150119403

Mutant ros expression in human cancer


The invention provides the identification of the presence of mutant ros protein in human cancer. In some embodiments, the mutant ros are fig-ros fusion proteins comprising part of the fig protein fused to the kinase domain of the ros kinase.
Cell Signaling Technology, Inc.
04/30/15
20150119330

Substrates and inhibitors of prolyl oligopeptidase and fibroblast activation protein and methods of use


Inhibitors of fibroblast activation protein alpha (fap) and prolyl oligopeptidase (pop) are disclosed, along with their use in various therapies related to conditions, diseases, and disorders involving abnormal cell proliferation such as malignancies and angiogenesis, and in neural disorders such as alzheimer's disease. Stalk portions of the inhibitor molecules, and substrates of fap and pop, are also disclosed and may be used, for example, in screening methods for identifying such inhibitors..
The Board Of Regents Of The University Of Oklahoma
04/30/15
20150118709

Corn active peptide additive for cell culture medium


The present invention provides a corn active peptide additive for cell culture medium, wherein in the corn active peptide additive, oligopeptides with molecular weight of lower than 1000 dalton account for equal to or more than 90 wt % of total proteins, and the oligopeptides at least comprise one or more of ap, sap, pal, vnap, pssq, and tqpgpq. The corn active peptide additive of the present invention can be compounded with various basic culture mediums for serum-free culture of various animal cells, which not only substantially lowers the cost for cell culturing and reduces pollution and other problems caused by an animal derived component, but also can promote cell proliferation, improve cell viability and enhance expression of cell products..
China National Research Institute Of Food And Fermentation Industries
04/30/15
20150118215

Methods of inhibiting cell proliferation


Described are methods of inhibiting cytohesin-2 to treat cancer, treat diabetic nephropathy, and deliver a compound into a cell.. .
The General Hospital Corporation
04/23/15
20150111970

Genetic markers and diagnostic methods for resistance of breast cancer to hormonal therapies


This application provides a method to identify genetic markers associated with increased sensitivity or resistance to hormonal therapies using an outlier analysis. More specifically, this application discloses that amplifications on chromosomes 8 and 17 are associated with increased proliferation and poor outcome in er-positive breast cancer, and amplicons 17q21.33-q25.1, 8p11.2 and 8q24.3 may be responsible for higher proliferation and poor outcome in the setting of antiestrogen, in particular tamoxifen, treatment clinically observed in a subset of er-positive, her2-negative breast cancers.
Rutgers, The State University Of New Jersey
04/23/15
20150111953

Modulator compounds of drug resistance in epithelial tumor cells


The described invention provides a method of treating a patient with an epithelial cancer comprising administering a composition comprising a therapeutic amount of an inhibitor of a btk protein and one or more chemotherapeutic agent(s) selected from the group consisting of an antimetabolite, a platinum coordination compound, an alkylating agent and a combination thereof, wherein the composition is effective to reduce one or more of tumor cell growth, tumor cell clonogenicity, tumor cell proliferation, tumor cell viability and tumor volume and the therapeutic amount of the inhibitor of a btk protein and the one or more chemotherapeutic agent(s) exerts a synergistic effect. The described invention also provides methods of treating a chemotherapy drug-resistant cancer and sensitizing a cancer patient to chemotherapy..
04/23/15
20150111891

Naphthalene acetic acid derivatives against hiv infection


The invention provides compounds and salts thereof as d herein. The invention also provides pharmaceutical compositions comprising a compound disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an hiv infection, treating the proliferation of the hiv virus, treating aids or delaying the onset of aids or arc symptoms in a mammal using compounds disclosed herein..
Gilead Sciences, Inc.
04/23/15
20150110846

Biphasic osteochondral scaffold for reconstruction of articular cartilage


An osteochondral scaffold has a chondrogenic spiral scaffold in one end of an outer shell made of sintered microspheres, and an osteogenic spiral scaffold in the other end of the outer shell. Each spiral scaffold has nanofibers of a composition selected to promote attachment and proliferation of the desired types of cells.
The Trustees Of The Stevens Institute Of Technology
04/23/15
20150110814

Combination therapies with psma ligand conjugates


Compositions and methods related to inhibiting the proliferation of or killing of prostate-specific membrane antigen (psma)-expressing cells are provided herein. In some embodiments, psma-expressing cells are contacted with (i) a compound that increases cell surface expression of psma and (ii) a psma ligand conjugate.
Psma Development Company, Llc
04/23/15
20150110774

S100 protein inhibitors for treating leukemia


The present invention relates to a compound, composition and method for reducing or inhibiting the differentiation or development of progenitor blood cells into malignant cells, leukemia cells or physiologically pathological cells. Particularly, the invention describes the use of inhibitors of s100 proteins, including myeloid related proteins.
Universite Laval
04/23/15
20150110737

Methods of producing and using regulatory b-cells


The invention is directed to a method of preparing b-cells that produce interleukin-10 (il-10), or il-10 per se, which comprises contacting one or more b-cells ex vivo with an isolated interleukin-35 (il-35) protein, and culturing the one or more b-cells under conditions to provide one or more b-cells that produce il-10. The invention also is directed to a method of suppressing the proliferation of lymphocytes in vitro or in vivo by contacting lymphocytes with an isolated il-35 protein.
The United States Of America, As Represented By Secretary, Department Of Health And Human Services
04/16/15
20150105465

Antiseptic compositions, methods and systems


Antiseptic compositions comprising at least one salt of edta are disclosed. These compositions have broad spectrum antimicrobial and antifungal activity and they also have anticoagulant properties.
Aseptica, Inc.
04/16/15
20150105441

Lim kinasemodulating agents for neurofibromatoses therapy and methods for screening for same


Disclosed herein are methods of treating a patient at risk of developing or having a neurofibromatosis or a sporadic schwannoma. In exemplary embodiments, the method involves administering to a subject in need an effective amount of a limk modulating agent.
University Of Central Florida Research Foundation, Inc.
04/16/15
20150104481

Water extract of antrodia camphorata for immunostimulatory effect and preparation method thereof


A preparation method for a water extract of the fruiting body of antrodia camphorata (acw) is provided. The method includes steps of: (a) providing the fruiting body; and (b) boiling the fruiting body in water to obtain the water extract.
Kaohsiung Medical University


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Proliferation topics: Proliferation, Cell Proliferation, Differentiation, Cancer Cell, Antibodies, Progesterone, Specificity, Cancer Cells, Antimicrobial, Lymphocyte, Cell Differentiation, Homogeneous, Amino Acids, Wound Healing, Epithelial

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