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Proliferation patents



      
           
This page is updated frequently with new Proliferation-related patent applications.



Date/App# patent app List of recent Proliferation-related patents
01/28/16
20160025708 
 Method for targetting growth and death of neoplastic cells by bursts of energies from cellular energy emissions patent thumbnailMethod for targetting growth and death of neoplastic cells by bursts of energies from cellular energy emissions
The embodiments herein disclose a non-invasive method of using bursts of energies/electromagnetic field energies from cells to reduce or arrest the growth rate, proliferation of cancer cells/neoplastic cells. The energy from cells induces apoptosis in cancer cells, without harming normal cells beyond their physiologic threshold of survival are provided.

01/28/16
20160024597 
 Mirnas as therapeutic targets in cancer patent thumbnailMirnas as therapeutic targets in cancer
Methods for modulating expression of a component of a cell, comprising contacting the cell with a nucleic acid comprising an mir-140 nucleic acid sequence in an amount sufficient to modulate the cellular component are provided. Overexpression of mir-140 inhibits cell proliferation in both u-2 os (wt-p53) and hct 116 (wt-p53) cell lines.
The Research Foundation For The State University Of New York


01/28/16
20160024501 
 Methods for inducing cardiomyocyte proliferation patent thumbnailMethods for inducing cardiomyocyte proliferation
Methods for inducing cardiomyocyte proliferation, e.g., in vivo, by administering a composition comprising mirna17-92 cluster oligonucleotides, e.g., mir-19a oligonucleotides, mir-19b oligonucleotides, or both mir-19a and mir-19b oligonucleotides.. .
Children's Medical Center Corporation


01/28/16
20160024473 
 Menstrual stems cells for the efficient support and expansion of cd34+ cd133+ hematopoietic stem cells in vitro patent thumbnailMenstrual stems cells for the efficient support and expansion of cd34+ cd133+ hematopoietic stem cells in vitro
The invention relates to highly proliferative stem cell obtained from menstrual fluid. The menstrual stern cells (menscs) may be cultured in vitro and exhibit mesenchymal stem cell (msc)-like properties and some culture and expansion advantages.
Cells For Cells


01/28/16
20160024467 
 Method for stem cell culture and cells derived therefrom patent thumbnailMethod for stem cell culture and cells derived therefrom
There is described a method of promoting the attachment, survival and/or proliferation of a stem cell in culture, the method comprising culturing a stem cell on a positively-charged support surface. There are also provided a cell composition prepared according to the method of the invention..
Es Cell International Pte Ltd


01/28/16
20160024212 
 Humanized anti-hla-dr antibodies patent thumbnailHumanized anti-hla-dr antibodies
The present invention concerns compositions and methods of use of humanized anti-hla-dr antibodies. In preferred embodiments, the antibodies induce apoptosis and inhibit proliferation of lymphoma cells without inducing cdc or adcc.
Immunomedics, Inc.


01/28/16
20160024104 
 Therapeutic compounds patent thumbnailTherapeutic compounds
Or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula i, processes for preparing compounds of formula i, intermediates useful for preparing compounds of formula i and therapeutic methods for treating the proliferation of the hiv virus, treating aids or delaying the onset of aids or arc symptoms in a mammal using compounds of formula i..

01/28/16
20160023926 
 Method and system for injecting rf signal into a fluid-containing system patent thumbnailMethod and system for injecting rf signal into a fluid-containing system
A method and system for injecting a pulsed radio frequency signal into a fluid-containing system in order to create and propagate an electromagnetic field throughout the fluid-containing system. Use electromagnetic field may be used to prevent the formation and build-up of scale in the fluid-containing system and/or to prevent the proliferation of bacteria within the fluid-containing system.
Msl Oilfield Services Limited


01/28/16
20160022635 
 Use of arginine vasopressin receptor antagonists for the treatment of prostate cancer patent thumbnailUse of arginine vasopressin receptor antagonists for the treatment of prostate cancer
Described herein are methods of decreasing the proliferation of prostate cancer cells in a mammalian subject by administering to a subject in need thereof a composition comprising an avpr antagonist in amount effective to decrease proliferation of the cancer cells. Also provided are methods of inducing prostate cancer cell death (or decreasing invasion migration of the prostate cancer cells) in a mammalian subject by administering to a subject in need thereof a composition comprising an avpr antagonist..
University Of Miami


01/21/16
20160018400 
 Diagnostic and prognostic biomarkers for prostate cancer and other disorders patent thumbnailDiagnostic and prognostic biomarkers for prostate cancer and other disorders
The present invention relates to the use of vps28 and/or vps13a as biomarkers for diagnosing prostate cancer, prostate intraepithelial neoplasia (pin) or atypical small acinar proliferation (asap) and to the use of vps13a, vps28 and/or naaladl2 as biomarkers for predicting the prognosis of prostate cancer. The invention also relates to the use of vps13a, vps28 and/or naaladl2 as biomarkers for determining the grade or pathological stage of prostate cancer and monitoring progression of prostate cancer.
Cancer Research Technology Limited


01/21/16
20160017319 

Method of screening cell clones


A method of screening cell clones expressing a high yield of a polypeptide of interest is provided. The method employs the consecutive use of fluorescence activated cell sorting followed by colony picking based selection of cell clones with high expression rates and high proliferation rates.

01/21/16
20160017028 

Pharmaceutical composition containing antagonist of egf family ligand as component


The present inventors identified inhibition of a combination of egfr ligands that serve as targets for inhibition of cancer cell proliferation. More specifically, ereg antagonists and tgfα antagonists were found to be useful as inhibitors of cell growth.
Chugai Seiyaku Kabushiki Kaisha


01/21/16
20160016952 

Substituted amino-pyrimidine derivatives


The present application provides novel substituted quinazoline and pyrido-pyrimidine compounds and pharmaceutically acceptable salts, prodrugs, and solvates thereof. Also provided are methods for preparing these compounds.
Asana Biosciences, Llc


01/21/16
20160015686 

Methods and compositions for increasing antibiotic activity


One aspect of the invention provides a method of inhibiting an efflux pump in a bacteria, the method comprising contacting the bacteria with 3,4-dibromopyrrole-2,5-dione, thereby inhibiting the efflux pump. Another aspect provides a method of inhibiting proliferation of a bacteria, the method comprising contacting the bacteria with 3,4-dibromopyrrole-2,5-dione and an antibiotic, thereby inhibiting the proliferation of the bacteria.
Woods Hole Oceanographic Institution


01/14/16
20160009728 

Anticancer compounds


In one aspect, the invention relates to compounds having anticancer activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with uncontrolled cellular proliferation using the compounds and compositions. This abstract is intended to be used as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention..
St. Jude Children's Research Hospital


01/14/16
20160009702 

Pyrazole compounds and methods of use thereof


The present invention comprises compounds of formula i and their use in the inhibition of cell proliferation in therapeutic treatments. Pharmaceutical compositions comprising at least one compound of formula i and at least one pharmaceutical excipient are disclosed, as well as methods of using compounds of formula i and pharmaceutical compositions thereof for treatment of hyper-proliferative diseases and other disorders..
Translational Drug Development, Llc


01/14/16
20160008388 

Compositions and methods for immunotherapy


The present invention provides novel immunotherapeutic compositions and methods useful for treating or preventing microbial infections, weakened immune systems, diseases in which cells have become obligately anerobic and cellular proliferative disorders including cancer. The immunotherapeutics herein use benzaldehyde derivatives, precursors and intermediaries alone or in combination with additional therapeutic agents to stimulate the immune system and inhibit cellular proliferation.

01/14/16
20160008307 

Methods and agents for preventing and treating plasma cell dyscrasias


Screening assays and methods of using same for screening to identify modulator agents or compounds that target endoplasmic reticulum stress related signaling pathways to induce apoptosis are described herein. Pharmaceutical compositions comprising modulator agents or compounds identified by screening assays described herein are also encompassed.
New York University


01/07/16
20160002629 

Diagnostic and treatment for chronic and acute phase myeloid leukemia


Disclosed are methods of predicting responsiveness of a cancer cell to a tyrosine kinase inhibitor, and methods of predicting the risk of progression of a cancer cell to a more aggressive form. Also provided are methods of reducing proliferation or promoting differentiation of a cancer cell having reduced level of numb or increased level of msi.
Duke University


01/07/16
20160002626 

Tox inhibition for the treatment of cancer


Described are methods for reducing the proliferation cancer cells by modulating the expression or activity of tox such as by use of a tox inhibitor. Inhibiting tox expression with antisense nucleic acids is shown to reduce the proliferation of malignant t cells.

01/07/16
20160002601 

Methods of upscaling mesenchymal stromal cell production, compositions and kit thereof


The present invention discloses a method of isolation, pooling and further culturing of mesenchymal stem cells (msc) for clinical application. Present invention also discloses the method of establishing master cell bank, followed by working cell bank from which the final therapeutic composition referred to as investigational product/investigational medicinal product comprising of allogenic bone marrow-derived msc is formulated for clinical applications.
Stempeutics Research Pvt. Ltd.


01/07/16
20160002340 

Zcytor17 heterodimeric cytokine receptor monoclonal antibodies


Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto..
Zymogenetics, Inc.


01/07/16
20160002316 

Serpins: methods of therapeutic beta-cell regeneration and function


Compositions and methods of use are provided for improving β cell function and promoting pancreatic β cell proliferation in vitro, in vivo and ex vivo. The active agents of the pending invention comprise serpin family peptides (e.g., serpinb1), functional and structural analogs of serpin family peptides and nucleic acids encoding serpin family peptides, as well as active fragments thereof..
Sanofi


01/07/16
20160002300 

Antimicrobial peptides derived from hepatitis b virus core protein arginine-rich domain


A pharmaceutical composition for use in killing and/or inhibiting the growth and/or proliferation of a microorganism in a subject in need thereof, or for treating a subject afflicted with a microbial infection is disclosed. The composition comprises: (a) an effective amount of an isolated peptide, wherein the peptide comprises the arginine-rich carboxy-terminal region of hepatitis b virus core protein (hbc) and exhibits an antimicrobial activity; and (b) a pharmaceutically acceptable carrier.
Academia Sinica


01/07/16
20160002243 

Inhibitors of bruton's tyrosine kinase


This application discloses compounds according to generic formula (i) wherein all variables are defined as described herein, which inhibit btk. The compounds disclosed herein are useful to modulate the activity of btk and treat diseases associated with excessive btk activity.
Hoffmann-la Roche Inc.


01/07/16
20160002230 

Pyrido[2,3-b]pyrazin-8-substituted compounds and their use


The present invention pertains generally to the field of therapeutic compounds for treating proliferative disorders, cancer, etc., and more specifically to certain pyrido[2,3-b]pyrazin-8-substituted compounds, as described herein, which, inter alia, inhibit raf (e.g., b-raf) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit raf (e.g., braf) activity, to inhibit receptor tyrosine kinase (rtk) activity, to inhibit cell proliferation, and in the treatment of diseases and disorders that are ameliorated by the inhibition of raf, rtk, etc., proliferative disorders such as cancer (e.g., colorectal cancer, melanoma), etc..
Cancer Research Technology Limited


01/07/16
20160002206 

Inhibitors of bruton's tyrosine kinase


This application discloses compounds according to generic formula i: (i) wherein all variables are defined as described herein, which inhibit btk. The compounds disclosed herein are useful to modulate the activity of btk and treat diseases associated with excessive btk activity.
Hoffmann-la Roche Inc.


01/07/16
20160000867 

Compositions and methods for modulating the immune system


A novel class of embryo derived peptides are described (preimplantation factor) that were generated synthetically and were tested on peripheral blood immune cells and shown to block activated but not basal immunity, inhibiting cell proliferation and creating a th2 type cytokine bias, in addition pif enhance endometrial receptivity by increasing adhesion molecules expression. Pif biological activity appears to be exerted by specific binding to inducible receptors present on the several white cell lineages.
Bioincept, Llc


01/07/16
20160000818 

Compositions including triciribine and one or more platinum compounds and methods of use thereof


This application encompasses combination therapies including triciribine and related compounds and one or more platinum compounds and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. .
University Of South Florida


01/07/16
20160000788 

Use of itk inhibitors for the treatment of cancer


This invention relates generally to the use of itk (il-2 inducible t-cell kinase) inhibitors for the treatment of patients who have melanoma or other solid tumors. Applicants demonstrate that itk lentiviral small hairpin rna knockdowns and a small molecule inhibitor can each decrease the proliferation and migration of melanoma cell lines and a small molecule inhibitor can be used to inhibit the growth of melanomas in vivo..
The University Of North Carolina At Chapel Hill


01/07/16
20160000754 

Antiviral activity from medicinal mushrooms and their active constituents


Compounds having unique antiviral properties found in mushroom mycelium and their analogs are extracted, concentrated, isolated or manufactured to create compositions useful in preventing the spread and proliferation of various viruses afflicting animals, particularly viruses harming humans, pigs, birds, bats and bees. Such compounds and compositions can be used individually or in combination with known medicines or natural products to improve health..

01/07/16
20160000064 

Platelet storage and reduced bacterial proliferation in platelet products using a sialidase inhibitor


The present invention relates to methods and compositions for reducing sialidase activity and inhibiting bacterial proliferation of one or more bacteria in a platelet product preparation from one or more donors. In general, the method includes contacting the platelet product preparation with an amount of a sialidase inhibitor, to thereby obtain a sialidase inhibitor-treated platelet product preparation.
The Brigham And Women's Hospital, Inc.


12/31/15
20150376276 

Anti-ntb-a antibodies and related compositions and methods


Disclosed are antibodies, including antibody drug conjugates, that specifically bind to ntb-a. Also disclosed are methods for using the anti-ntb-a antibodies to detect or modulate activity of (e.g., inhibit proliferation of) an ntb-a-expressing cell, as well as for diagnoses or treatment of diseases or disorders (e.g., cancer) associated with ntb-a-expressing cells.
Seattle Genetics, Inc.


12/31/15
20150376166 

Inhibitors of bruton's tyrosine kinase


This application discloses compounds according to generic formula (i): wherein all variables are defined as described herein, which inhibit btk. The compounds disclosed herein are useful to modulate the activity of btk and treat diseases associated with excessive btk activity.
Hoffmann-la Roche Inc.


12/31/15
20150376141 

New compounds


A, b, x, r1 to r3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.. .

12/31/15
20150376133 

C-met modulators and methods of use


The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-met, kdr, c-kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
Exelixis, Inc.


12/31/15
20150376124 

Anti-cancer compositions and methods


Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by akt dysregulation.
The Penn State Research Foundation


12/31/15
20150376123 

Biguanide derivative, preparation method thereof, and pharmaceutical composition containing same as an active ingredient


A biguanide derivative compound with n4-n5 substitution, which is represented by formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of ampk and inhibition of cancer cell proliferation in a low dose, compared with conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc..
Hanall Biopharma Co., Ltd.


12/31/15
20150374802 

Compositions and methods for treating inflammatory diseases


The invention provides compositions and methods for treating inflammatory diseases, such as cardiac or hepatic inflammatory diseases, involving the use of parasite-derived neurotrophic factor (pdnf), or fragment of pdnf. The invention also provides compositions featuring pdnf, or a fragment thereof, and methods for using such compositions for the proliferation and/or mobilization of a stem cell (e.g., cardiac stem cell) or progenitor cell (e.g., hepatic progenitor cell).
Tufts University


12/31/15
20150374771 

Anti-ageing activity of camphor in fibroblast cell line


The present invention provides a composition for skin regeneration including chamomile hydrosol prepared by vacuum distillation as an active ingredient. The composition for skin regeneration including camphor or chamomile hydrosol prepared by vacuum distillation, which contains the camphor, exhibits to excellent skin regeneration ability to promote proliferation and migration of skin cells, and simultaneously include only components derived from natural herbal plants, and thus can be used in various forms such as medicine, quasi-drugs, cosmetics, and food materials without any of side effects..
Urban Farmers Co., Ltd.


12/31/15
20150374738 

Compositions and methods for regulating cell growth and development


The invention relates to the field of basic biology, practical regenerative medicine, veterinary, cell biology and can be used to treat and prevent diseases, disorders or conditions associated with the violation of proliferation and differentiation of cells of different organs and tissues to activate the regeneration potential of human and animal organs and tissues at age-related changes and after extreme impacts, as well as for biomedical research. The present invention can be widely applied in the field of blood transfusion, organ transplantation, as well as serve as a general approach to the development of reliable methods to correct age-related changes in the elderly.
Aovart Gmbh


12/31/15
20150374707 

Methods and compounds for the inhibition of cellular proliferation


Methods for inhibiting translation, treating a cellular proliferative disorder, and inhibiting proliferation of cells using the compounds disclosed herein are provided.. .
President And Fellows Of Harvard College


12/24/15
20150368613 

Compositions and methods for the expansion of stem cells


The present disclosure relates to methods for expansion of stem cell populations using a polypeptide that enhances stem cell growth and proliferation. The present disclosure further relates to novel homeobox protein mutants (e.g., hoxa9 and hoxb4 mutant proteins) and the use thereof to expand certain stem cell populations.
Cornell University


12/24/15
20150368198 

N1-cyclic amine-n5-substituted biguanide derivatives, methods of preparing the same and pharmaceutical composition comprising the same


The present invention provides an n1-cyclic amine-n5-substituted biguanide derivative compound represented by formula 1, a method of preparing the same and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient. The biguanide derivatives have an effect of inhibiting cancer cell proliferation, cancer metastasis and cancer recurrence by activation of ampk, even when administered in a small dose compared with conventional drugs..
Hanall Biopharma Co., Ltd.


12/24/15
20150366940 

Serpins: methods of therapeutic b-cell regeneration and function


Compositions and methods of use are provided for improving β cell function and promoting pancreatic β cell proliferation in vitro, in vivo and ex vivo. The active agents of the pending invention comprise serpin family peptides (e.g., serpinb1), functional and structural analogs of serpin family peptides and nucleic acids encoding serpin family peptides, as well as active fragments thereof..
Joslin Diabetes Center, Inc.


12/24/15
20150366936 

Inhibition of drug resistant cancer cells


Provided herein are methods of treating cancer in a cancer patient by overcoming resistance of a cancer cell to a drug, or methods of overcoming resistance of a cancer cell to a drug, comprising administering to the patient an effective amount of (i) an egfr tyrosine kinase inhibitor or a b-raf kinase inhibitor, and (ii) an hdac inhibitor. Also provided are methods for inhibiting or preventing proliferation of drug tolerant persister (dtp) cells comprising contacting these cells with an egfr tyrosine kinase inhibitor or b-raf kinase inhibitor in combination with an hdac inhibitor.
Celgene Corporation


12/24/15
20150366915 

Pharmaceutical preparations of human rpe cells and uses thereof


This disclosure provides the first description of hesc-derived cells transplanted into human patients. Results are reported for one patient with each of stargardt's macular dystrophy (smd) and dry age-related macular degeneration (amd).
Ocata Therapeutics, Inc.


12/24/15
20150366910 

Natural killer cells from placenta


Provided herein are placental perfusate, placental perfusate cells, placenta-derived intermediate natural killer cells, combined natural killer cells from placenta and umbilical cord blood, and combinations thereof. Also provided herein are compositions comprising the same, and methods of using placental perfusate, placental perfusate cells, placenta-derived intermediate natural killer cells, and combined natural killer cells and combinations thereof, to suppress the growth or proliferation of tumor cells, cancer cells, and the like, and to treat individuals having tumor cells.
Anthrogenesis Corporation


12/24/15
20150366883 

Method of treating ovarian cancer using a pkc inhibitor


A method of treating ovarian cancer by administering a pkc inhibitor is presented herein. It was found that administering a pkc inhibitor, such as acpd or ica-1, to ovarian cancer cells inhibited cancer cell proliferation..
University Of South Florida


12/17/15
20150362247 

Defrost appliance


A defrost appliance is provided that over comes the limitations of other methods of defrosting by use of an insulated closed inner shell, providing refrigeration and ultra violet light to control the proliferation of bacteria and circulating liquid via a pump raining it down on sealed frozen food to expedite thawing of frozen food in a controlled environment a quick, efficient, safe, easy to use means for defrosting frozen food.. .

12/17/15
20150361165 

Mfap4 binding antibodies blocking the interaction between mfap4 and integrin receptors


Microfibrillar-associated protein 4 (mfap4) binding antibodies are provided to prevent or to inhibit the proliferation of vascular smooth muscle cells and neointima formation in blood vessels. Furthermore, there are provided antibodies that effectively inhibit remodelling of vessels and prevent progression of arteriosclerosis as well as restenosis of vessels.
Syddansk Universitet


12/17/15
20150361134 

Compounds for proteasome enzyme inhibition


Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of n-terminal nucleophile (ntn) hydrolases. The activities of those ntn having multiple activities can be differentially inhibited by the compounds described.
Onyx Therapeutics, Inc.


12/17/15
20150360924 

Water dispenser


A water dispenser is provided in which proliferation of bacteria is less likely to occur in an inner peripheral portion of a cap of a raw water container. In this water dispenser, the cap includes the inner peripheral portion which forms a water outlet port; and a plug closing the water outlet port.
Kabushiki Kaisha Cosmo Life


12/17/15
20150359883 

Treatment of carcinomas with a combination of egf-pathway and telomerase inhibitors


A method and kit for inhibiting the proliferation of carcinoma cells are disclosed, based on a combination of an egf pathway inhibitor and a telomerase inhibitor. When used in cancer therapy, the two compounds in combination enhance the anti-cancer treatment efficacy obtained with the antibody alone or the telomerase inhibitor alone..
Geron Corporation


12/17/15
20150359851 

Methods of treating vestibular schwannoma and reducing hearing or neurite loss caused by vestibular schwannoma


Methods to reduce the proliferation of vestibular schwannoma (vs) cells and/or provide neuroprotection to reduce the risk of sensorineural hearing loss (snhl), vestibular dysfunction and facial nerve paralysis in subjects with vs. The methods can include one or more of decreasing tnf-α activity or expression; decreasing nf-κb expression or activity; decreasing cox-2 expression or activity; administering fgf2; decreasing hgf expression or activity; or decreasing c-met expression or activity..
Massachusetts Eye And Ear Infirmary


12/17/15
20150359774 

Active fraction of a polar solvent extract from the latex of euphorbiaceae plants


The present invention generally refers to an active fraction of an extract of the latex of plants from the family euphorbiaceae in a polar solvent, as well as of one or more compounds contained therein, as well as the use of said fraction and/or said compounds, particularly in the treatment of cancer. The invention also refers to compositions comprising said active fraction and/or said compounds, as well as their use for the treatment of diseases concerning cell proliferation/angiogenesis, particularly cancer..
Amazonia Fitomedicamentos Ltda.


12/17/15
20150359620 

Stent


A stent is configured to facilitate directional proliferation of cells on the inner surface of the stent to relatively quickly coat the stent surface with the cells so that the onset of late stent thrombosis or restenosis can be reduced or prevented. The stent includes a cylindrical stent main body having openings at both ends and extending along the longitudinal direction between the openings at both ends.
Terumo Kabushiki Kaisha


12/17/15
20150359619 

Small diameter vascular graft produced by a hybrid method


The present invention relates to a hybrid graft and methods of generating the hybrid graft. The hybrid graft comprises an exterior surface and a luminal surface.
The Trustees Of The University Of Pennsylvania


12/10/15
20150353935 

Melk regulation for the treatment of breast cancer


Methods for inhibiting growth or proliferation of breast cancer cells are provided. The methods include administering to a subject in need thereof in an amount that is effective to inhibit growth or proliferation of the breast cancer cells a melk inhibitor, wherein the breast cancer cells are estrogen receptor (er) negative.
Dana-farber Cancer Institute, Inc.


12/10/15
20150353928 

Genes contributing to survival of cancer cells


The invention relates to methods of inhibiting the growth or proliferation of a cell, the method comprising reducing the expression or activity of at least one gene in the cell selected from the group consisting of bloc1s1, cdc2l1, cnot1, cyr61, ddx54, eif3i, fancg, fbp1, ier2, kif1a, lck, nr2f1, pnrc1, polr2a, polr2b, polr2c, prpf6, psmb4, psmc5, psmd1, ptk7, rps2, scnn1a, sf3a3, taf2, tob1, tsc22d4.. .
Fox Chase Cancer Center


12/10/15
20150353898 

Baculoviral dna elements for the expression of recombinant proteins in a host cell


Reagents and methods are provided that allow for an improved expression of a recombinant protein. More specifically, the introduction of recombinant dna elements into a host cell allows for the increased expression of a recombinant protein, an improvement of the correct folding of said protein and an increase in cell viability and proliferation of the host cell, these recombinant dna elements can be introduced into host cells, for example, via a recombinant baculovirus, which has incorporated said elements.

12/10/15
20150353534 

Thiazole derivatives as inhibitors of bruton's tyrosine kinase


This application discloses compounds according to generic formula i: wherein all variables are defined as described herein, which inhibit btk. The compounds disclosed herein are useful to modulate the activity of btk and treat diseases associated with excessive btk activity.
Hoffmann-la Roche Inc.


12/10/15
20150353473 

Novel anticancer agent


Wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, particularly 1-((2-((2-methoxyphenyl)amino)ethyl)amino)-3-(1-naphthyloxy)propan-2-ol, or a pharmaceutically acceptable salt thereof. The compound shows a cell proliferation suppressive action on a wide range of cancer cells, is useful as an anti-cancer agent, and is useful for the prophylaxis and/or treatment of cancer..

12/10/15
20150352229 

Apparatus for facilitating cell growth in an implantable sensor


Apparatus is provided that contains cells for implantation into a human subject. The apparatus includes a substantially non-degradable three-dimensional scaffold having surfaces to which the cells are attached, and a hydrogel, which is attached to the cells.
Glusense, Ltd.


12/10/15
20150352186 

Factor 1 protein, factor 2 protein and inhibitors thereof for use in treating or preventing diseases


The present invention relates to proteins comprising amino acid sequences encoded by nucleic acids derived from the human chromosomal region c19orf10 termed factor1 and/or c19orf63 termed factor 2 for the use in enhancing proliferation and/or healing and/or inhibiting apoptosis of none-transformed tissue or none-transformed cell or inhibitors thereof. The invention further relates to the use of inhibitors of factor1 and factor 2 for medical use, preferably for use in treating or preventing a disease in which angiogenesis contributes to disease development or progression..
Medizinische Hochschule Hannover


12/03/15
20150344849 

Ex vivo culture, proliferation and expansion of intestinal epithelium


Methods are provided for long term culture of mammalian intestinal cells. Cultures are initiated with fragments of mammalian intestinal tissue, which are then maintained embedded in a gel substrate that provides an air-liquid interface.
The Board Of Trustees Of The Leland Standford Junior University


12/03/15
20150344848 

Sulfated depolymerized derivatives of exopolysaccharides (eps) from mesophilic marine bacteria, preparing same, and uses therof in tissue regeneration


The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (epss) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native epss followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues.
University Rene Descartes Paris 5


12/03/15
20150344537 

Non-transgene transfection for therapeutic purposes


This disclosure describes compositions and methods involved in tumor suppression and inhibiting infection of cells by pathogens. Generally, the compositions include an mrna cargo that can provide a therapeutic benefit after being introduced into an epithelial cell.

12/03/15
20150344477 

Helquat derivatives, preparation thereof, and use thereof as medicaments


The helquat derivatives are useful as medicaments in the treatment of diseases related to increased cellular proliferation, such as oncologic diseases.. .

12/03/15
20150342982 

Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms


Provided herein are methods for reducing neoplastic progenitor cell proliferation and alleviating symptoms associated in individuals diagnosed with or thought to have myeloproliferative disorders, such as essential thrombocythemia (et). Also provided herein are methods for using telomerase inhibitors for maintaining blood platelet counts at relatively normal ranges in the blood of individuals diagnosed with or suspected of having myeloproliferative disorders, such as et..
Geron Corporation


12/03/15
20150342945 

Substituted quinoline compounds and methods of use


The present invention provides novel substituted quinoline compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans..
Sunshine Lake Pharma Co., Ltd.


11/26/15
20150337310 

Splice modulating oligonucleotides that inhibit cancer


A method of treating cancer in a subject is provided. The method includes administering a splice modulating oligonucleotide to the subject in an amount effective to provide a therapeutic benefit to the subject.
The Regents Of The University Of California


11/26/15
20150337264 

Composition comprising ischemic serum for promoting activation of stem cell and promoting activation of stem cell


The present invention relates to a composition comprising an ischemic serum for promoting the activation of a stem cell, to a method for promoting the activation of a stem cell and to a stem cell, the activation of which is promoted by the composition or the method. The ischemic serum according to the present invention may stimulate the stem cell to facilitate the secretion of a growth factor, improve survival rate, improve mobility to an injured part, improve proliferation rate and maintain characteristics of the stem cell, thus promoting an activation of the stem cell such that the stem cell becomes suitable for transplantation of the stem cell to a patient having a brain injury..
Samsung Life Public Welfare Foundation


11/26/15
20150337253 

Method for removing bacterial contaminants from saccharified solution and fermentation system


A method for removing bacterial contaminants from a saccharified solution capable of suppressing proliferation of bacterial contaminants in a fermentation tank without using an antibiotic in alcoholic fermentation of a biomass saccharified solution using normal yeast, and a fermentation system suited for conducting the method are provided. The method and system include drawing out a saccharified solution from a fermentation tank, conducting rough separation for recovering yeast from the solution, and conducting fine separation for removing bacterial contaminants from the solution, thereby removing only the contaminants while recovering yeast.
Kawasaki Jukogyo Kabushiki Kaisha


11/26/15
20150337025 

Use of fusion protein


Disclosed is the use of a fusion protein in drugs for stimulating differentiation of bone marrow mesenchymal stem cells to hematopoietic stem/progenitor cells, or drugs for proliferation of granulocyte hematopoietic progenitor cells. The fusion protein has a sequence as shown in seq id no: 2 or seq id no: 4.
East China University Of Science And Technology


11/26/15
20150336982 

Five-and-six-membered heterocyclic compound, and preparation method, pharmaceutical composition and use thereof


A five-and-six-membered heterocyclic compound as represented by general formula i, pharmaceutically acceptable salt, metabolite, metabolic precursors or drug precursors thereof, preparation method, pharmaceutical composition, and use thereof; the five-and-six-membered heterocyclic compound has activity as a janus kinase (jak) inhibitor, and can be used to prepare drugs for treating diseases caused by the abnormal activity of kinase, such as cell proliferation diseases like cancer.. .
Shanghai Chemexplorer Co., Ltd.




Proliferation topics: Proliferation, Cell Proliferation, Differentiation, Cancer Cell, Antibodies, Progesterone, Specificity, Cancer Cells, Antimicrobial, Lymphocyte, Cell Differentiation, Homogeneous, Amino Acids, Wound Healing, Epithelial

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