This page is updated frequently with new Proliferation-related patent applications.
|Methods and compositions for cell-proliferation-related disorders|
Methods of treating and evaluating subjects having neoactive mutants of idh (e.g., idh1 or idh2).. .
Agios Pharmaceuticals, Inc.
|Mirnas enhancing cell productivity|
The invention relates to a nucleic acid construct comprising at least two different regions, wherein the regions are selected of a first region encoding for at least one mirna stimulating cellular production of a biomolecule in a cell, a second region encoding for at least one mirna and/or mirna-inhibitor suppressing cell death, and a third region encoding for at least one mirna and/or mirna-inhibitor regulating cell proliferation. The invention further relates to a cell comprising a respective nucleic acid construct and to a method for increasing the yield of a biomolecule produced by a cell cultured in vitro comprising at least two steps selected of stimulating cellular production of the biomolecule, reducing cell death, and regulating proliferation..
|Cell tracking reagents and their methods of use|
Described herein are compounds, methods, and kits for short- and long-term tracking of cell proliferation, differentiation, and/or function. The compounds disclosed herein are rhodamine-based cell-tracking reagents that fluoresce in the red portion of the uv/vis spectrum and provide bright fluorescence intensity, uniform cell staining, and good retention within live cells as well as low toxicity toward cells..
Life Technologiies Corporation
|Anticancer peptide for inhibiting proliferation of cancer stem cells and use thereof|
The present invention relates to an anticancer composition comprising a peptide that inhibits the proliferation of cancer stem cells present in tumor tissue and that induces apoptosis of such cancer stem cells, and more particularly, to an anticancer peptide that inhibits the activity of nf-κb which is overexpressed specifically in cancer stem cells present in tumors.. .
Nano Intelligent Biomedical Engineering Corporation Co., Ltd.
|Deep sea water extract and use thereof|
The present invention provides a deep sea water extract and a method for inhibiting the proliferation of helicobacter pylori strains using the deep sea water extract, wherein the deep sea water extract has an organic component with a molecular weight of 685 to 690, 733 to 738 and 1,070 to 1,075. The deep sea water extract of the present invention can be applied in the prevention and treatment of h pylori infection..
Taiwan Dow Biotech Co., Ltd.
|Methods for treating t-cell acute lymphoblastic leukemia|
The present invention is directed to methods of treating t-all that involve administering an inhibitor of jumonji d3 (jmjd3) demethylase. Another embodiment of the invention relates to methods inhibiting t-all cell proliferation and/or survival that involves administering an inhibitor of jumonji d3 (jmjd3) demethylase to a population of t-all cells..
New York University
|Protection of progenitor cells and regulation of their differentiation|
The present invention relates to the use of polysulfated polysaccharides in combination with progenitor cells to improve the viability of the progenitor cells including improving the cryopreservation of the progenitor cells and provides novel compositions, methods and uses. The present invention also relates to the use of polysulfated polysaccharides to regulate the proliferation and differentiation of progenitor cells..
Proteobioactives Pty Ltd.
|Methods and compositions for immune dis-inhibition|
The disclosure provides methods and compositions for immune dis-inhibition. In certain embodiments, the methods comprise administering an effective amount of an agent that decreases the amount of a soluble cytotoxic receptor or inhibits its activity.
|Method for preparing and using cell ghost with active factors as synergist of lymphocyte in vitro culture|
Provided is a method for preparing and using cell ghosts with active factors as a synergist of a lymphocyte in vitro culture. The method for preparing cell ghosts comprises: washing a cell to obtain a washed cell; and cleaving the washed cell to obtain cell ghosts, wherein the cell has cytokines capable of promoting the proliferation and differentiation of lymphocytes on their surface..
|Methods and devices to prevent premature birth|
Methods and devices to affect types, proportion, quantity, distribution, or proliferation of microorganisms within a female reproductive system.. .
Method for proliferation of antigen-specific t cells
The present invention relates to an in vitro method for priming genetically modified t cells suitable for administration to a patient having a tumor. The invention is also directed to the composition obtained by the method and uses thereof..
Compositions for the treatment of peripheral ulcers of various origins
The present invention relates to combinations of an agent that stimulates cell proliferation and an anti-inflammatory/analgesic, which are useful in the treatment of peripheral ulcers of various origins, such as radiation dermatitis, diabetic ulcers, ulcers caused by venous stasis of the limbs, bedsores, and the associated skin infections, proctitis, vulvovaginitis and haemorrhoids with vascular lesions. These combinations can be presented as formulations for topical use..
Ex vivo proliferation of epithelial cells
The technology relates in part to methods and compositions for ex vivo proliferation and expansion of epithelial cells.. .
Ex vivo proliferation of epithelial cells
The technology relates in part to methods and compositions for ex vivo proliferation and expansion of epithelial cells.. .
Heterocyclic compounds and uses thereof
The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, egfr (including her), alk, pdgfr, blk, bmx/etk, flt3(d835y), itk, tec, txk, btk, or jak, and the respective pathways.. .
Acea Biosciences Inc.
Pyrimidine compound and medical use thereof
Wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like.
At-home light-emitting diode and massage device for vaginal rejuvenation
A light emitting module and massage device provide vaginal rejuvenation. The device exposes collagen in the vaginal area or mucosa to temperatures elevated over normal body temperature to cause the collagen to reversibly or irreversibly denature while simultaneously applying vibration.
Quinazolines and azaquinazolines as dual inhibitors of ras/raf/mek/erk and pi3k/akt/pten/mtor pathways
The present application provides novel quinazolines and azaquinazolines and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds.
Asana Biosciences, Llc
Method for generating endothelial colony forming cell-like cells
The present disclosure relates generally to methods and compositions useful in cell and tissue biology and therapeutics. In particular, an in vitro method for differentiating pluripotent cells into endothelial colony forming cell-like cells (ecfc-like cells) is provided.
Indiana University Research And Technology Corporation
Modulating cell proliferation and pluripotency
Disclosed herein are compositions, systems, and methods for modulating proliferation, differentiation and pluripotency of cells.. .
Memorial Sloan Kettering Cancer Center
Compounds for eradicating or inhibiting proliferation of cancer stem cells
The present invention provides compounds of formula (i), compositions, uses thereof and methods for eradicating or inhibiting proliferation of cancer stem cells which includes killing; and/or inducing apoptosis in cancer stem cells. Included within the scope of such compounds, compositions, uses thereof and methods are those in which proliferation of cancer stem cells are selectively eradicated or inhibited..
Godavari Biorefineries Limited
Enzymatic debridement therapy for abnormal cell proliferation
Compositions and methods are provided to destroy internal cancerous lesions selectively by the administration of a combination of a debridement protease enzyme and a denaturant of cell structural proteins and or cell adhesion proteins.. .
Methods and compositions for treatment of metastatic and refractory cancers and tumors
A method of treating a mammalian subject with cancer comprises administering to said subject having a cancer, e.g., a metastatic or refractory cancer or tumor, a small molecule inhibitor of a target signaling molecule of the mek/mapk pathway that impairs t cell activation, and administering to said subject a molecule that induces t cell proliferation in the presence of said inhibitor. The combination of a small molecule inhibitor of a target of the mek/mapk pathway and the t cell proliferation inducer reduces the proliferation of the cancer and tumor cells in vivo.
The Wistar Institute Of Anatomy And Biology
Cell-surface marker of early msc aging
This invention relates to a cell-surface marker for identifying msc that are aging. This invention also relates to a method of screening mscs of low proliferation potential and trilineage potential by removing cd264+ mscs from the population..
The Administrators Of The Tulane Educational Fund
Defined composition gene modified t-cell products
Aspects of the invention described herein, concern approaches to make genetically modified t-cells comprising a chimeric antigen receptor for human therapy. In some alternatives, the methods utilize a selection and/or isolation of cd4+ and/or cd8+ t-cells from a mixed t-cell population, such as, peripheral blood or apheresis derived mononuclear cells.
Seattle Children's Hospital (dba Seattle Children's Research Institute)
Methods, compositions and screens for therapeutics for the treatment of synovial sarcoma
Methods and compositions are provided for treating human synovial sarcoma (ss). Also provided are screens to identify therapeutics for the treatment of synovial sarcoma.
The Board Of Trustees Of The Leland Stanford Junior University
Induction of thyroid iodide-handling gene expression in human cancers
Dual suppression of the map kinase and pi3k/akt pathways showed synergistic or greatly enhanced anti-melanoma cell effects, compared to suppression of a single pathway, including the inhibition of cell proliferation, transformation and invasion, induction of g0/g1 cell cycle arrest and, importantly, cell apoptosis. Remarkably, suppression of either pathway induces the expression of thyroid iodide-handling genes and dual suppression of the two pathways synergistically and robustly induces expression of these genes, accompanied by uptake of radioiodine in the cells.
The Johns Hopkins University
Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof
The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.. .
University Of Maryland, Baltimore County
Medium for stem cell use
Culture media which contain a water-soluble polymer, such as polyvinyl alcohol and the like, and albumin, and the like, are useful for the proliferation of stem cells, and show good culture results, particularly with ips cells, and maintain the stability of the medium properties, as well as using a reduced amount of albumin.. .
Ajinomoto Co., Inc.
Novel cyp-eicosanoid derivatives
The present invention relates to compounds according to general formula (i) which are analogues of epoxymetabolites produced by cytochrome p450 (cyp) enzymes from omega-3 (n-3) polyunsaturated fatty acids (pufas). The present invention further relates to compositions containing one or more of these compounds and to the use of these compounds or compositions for c the treatment or prevention of conditions and diseases associated with inflammation, proliferation, hypertension, coagulation, immune function, pathologic angiogenesis, heart failure and cardiac arrhythmias..
Board Of Regents, The University Of Texas System
Composition for inducing proliferation or accumulation of regulatory t cells
It was found that bacteria belonging to the genus clostridium induce accumulation of regulatory t cells (treg cells) in the colon. Moreover, the present inventors found that regulatory t cells (treg cells) induced by from these bacteria suppressed proliferation of effector t-cells.
The University Of Tokyo
Methods of generating natural killer cells
Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising administering the nk cells produced by the method to an individual having the cancer or viral infection..
Compositions and methods of using islet neogenesis peptides and analogs thereof
The invention provides peptides and analogs of ingap and hip peptides. The peptides and analogs can be used in methods for treating various diseases and conditions.
Shenzhen Hightide Biopharmaceutical, Ltd.
4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase
Human lipoxygenases (loxs) are a family of iron-containing enzymes involved in catalyzing the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive hydroxyeicosatetraenoic acid (hete) metabolites. These eicosanoid signaling molecules are involved in a number of physiologic responses such as platelet aggregation, inflammation, and cell proliferation.
Thomas Jefferson University
Brown adipocyte modification
Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss.
The General Hospital Corporation D/b/a Massachusetts General Hospital
The invention provides a skin disinfectant for treating skin with eczema, preventing bacterial proliferation, and removing biofilm. Compositions of the invention include hypochlorous acid, acetic acid, water, and one or more additives or excipients.
Wiab Water Innovation Ab
Gel composition for treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt
Dermatological/cosmetic compositions suited for preventing or treating cell differentiation and/or proliferation and/or keratinization disorders, including preventing or treating common acne, comprise, in a physiologically acceptable medium, (i) at least one dispersed retinoid, (ii) dispersed benzoyl peroxide, in free or encapsulated form, and (iii) at least one ph-independent gelling agent, selected from the group consisting of (a) polyacrylamide gelling agents, (b) gelling agents which are acrylic polymers coupled to hydrophobic chains, (c) modified starch gelling agents, and mixture thereof, said composition maintaining good chemical stability of (i) and (ii) without their degradation over time at a temperature of between 4° c. And 40° c..
Galderma Research & Development
Defined three-dimensional microenvironment for stem cell
This disclosure provides for a three-dimensional (3d) microenvironment presenting defined physical or mechanical cues that regulate cellular behavior and use of the matrix. The disclosure also provides for devices and methods for screening for optimal combinations of physical and mechanical cues in order to create a microenvironment that can regulate specific cellular behavior such as cell growth, proliferation, migration or differentiation..
Konkuk University Industrial Cooperation Corp.
Methods for analysis of somatic mobile elements, and uses thereof
Methods and compositions related to the use of mobile element insertions and their adjacent genomic sequences. Methods using meis as markers for cellular proliferation, as targets for pharmaceuticals, as markers for tissue fingerprinting and in related methods and compositions are disclosed herein.
Igenomx International Genomics Corporation