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Proliferation patents



      
           
This page is updated frequently with new Proliferation-related patent applications. Subscribe to the Proliferation RSS feed to automatically get the update: related Proliferation RSS feeds. RSS updates for this page: Proliferation RSS RSS


Date/App# patent app List of recent Proliferation-related patents
10/23/14
20140315965
 Bis-(aryl/heteroaryl)-methylene compounds, pharmaceutical compositions containing same and their use for treating cancer patent thumbnailBis-(aryl/heteroaryl)-methylene compounds, pharmaceutical compositions containing same and their use for treating cancer
The present disclosure relates to novel compounds having vitamin d receptor agonist and histone deacetylase inhibitory efficacy as well as methods for reducing or inhibiting the proliferation of cancer cells or for treating cancer.. .
10/23/14
20140315956
 Small molecule inhibitors of il-6 and uses thereof patent thumbnailSmall molecule inhibitors of il-6 and uses thereof
In one aspect, the invention relates to substituted 2-(1h-indol-3-yl)ethanol analogs and substituted 3,3a,8,8a-tetrahydro-2h-furo[2,3-b]indole analogs, derivatives thereof, and related compounds, which are useful as inhibitors of il-6 mediated activation of the jak2/stat3 pathway; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a il6 dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention..
10/23/14
20140315920
 Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors patent thumbnailTreatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors
The present invention concerns methods for treating a proliferation disorder, such as prostate cancer, basal cell carcinoma, lung cancer, and other cancers, using an inhibitor of the hedgehog pathway (hhp); and methods for monitoring subjects undergoing such treatments based on biomarkers and other criteria predictive of efficacy.. .
10/23/14
20140315825
 Anti-cancer compositions containing wnt decoy receptor patent thumbnailAnti-cancer compositions containing wnt decoy receptor
The present invention relates to a composition for preventing or treating cancer comprising wnt decoy receptor. The composition of the present invention or the expression product thereof inhibits cancer generation, growth, proliferation and metastasis, and induces apoptosis of cancer cells, by binding to wnt ligand and blocking ligand-receptor interactions, therefore may be effectively used as an anti-cancer agent..
10/23/14
20140315741
 Methods and materials for modulating deubiquitinases and ubiquitinated polypeptides patent thumbnailMethods and materials for modulating deubiquitinases and ubiquitinated polypeptides
This document relates to methods and materials involved in modulating deubiquitinases (e.g., usp10 polypeptides) and/or ubiquitinated polypeptides (e.g., tumor suppressor polypeptides or mutant versions of tumor suppressor polypeptides). For example, methods and materials for increasing deubiquitinase (e.g., a usp10 polypeptide) expression or activity, methods and materials for decreasing deubiquitinase (e.g., a usp10 polypeptide) expression or activity, methods and materials for stabilizing tumor suppressor polypeptides (e.g., wild-type p53 polypeptides), methods and materials for de-stabilizing mutant versions of tumor suppressor polypeptides (e.g., mutant p53 polypeptides), and methods and materials for reducing cancer cell proliferation, increasing cancer cell apoptosis, and/or treating cancer (e.g., cancers having reduced levels of wild-type p53 polypeptides or cancers having increased levels of mutant p53 polypeptides) are provided.
10/23/14
20140314824
 Porous scaffold for tissue engineering and preparation method thereof patent thumbnailPorous scaffold for tissue engineering and preparation method thereof
A porous artificial transplant material to replace autogenous bone with excellent biocompatibility, cytocompatibility and biodegradability is provided. More specifically, a porous scaffold for tissue engineering including chitosan/hydroxyapatite-amylopectin (chitosan/hap-ap) and a preparation method thereof are provided.
10/23/14
20140314795
 Method and compositions for cellular immunotherapy patent thumbnailMethod and compositions for cellular immunotherapy
The present invention provides methods and compositions to confer and/or augment immune responses mediated by cellular immunotherapy, such as by adoptively transferring genetically modified tumor specific cd8+ t cells in the presence of tumor-specific, subset specific genetically modified cd4+ t cells, wherein the cd4+ t cells confer and/or augment a cd8+ t cells ability to sustain anti-tumor reactivity and increase and/or maximize tumor-specific proliferation of the tumor-specific cd8+ t cells of interest. Pharmaceutical formulations produced by the method, and methods of using the same, are also described..
10/23/14
20140314712
 Fusion protein comprising an interleukin 4 and interleukin patent thumbnailFusion protein comprising an interleukin 4 and interleukin
The invention is concerned with a fusion protein comprising interleukin 10 and interleukin 4, a nucleic acid molecule encoding such fusion protein, a vector comprising such nucleic acid molecule, and a host cell comprising such nucleic acid molecule or such vector. The invention further pertains to a method for producing such fusion protein.
10/16/14
20140309292
 Mutations of histone proteins associated with proliferative disorders patent thumbnailMutations of histone proteins associated with proliferative disorders
The present application shows the relationship between variations in the amino acid sequence of histone proteins, more specifically the h3.3 protein, and proliferation-associated disorders. Herewith provided are predictive methods, commercial packages, therapeutic methods and screening methods based on this relationship..
10/16/14
20140309259
 Derivatives of 1-(substituted sulfonyl)-2-aminoimidazoline as antitumor and antiproliferative agents patent thumbnailDerivatives of 1-(substituted sulfonyl)-2-aminoimidazoline as antitumor and antiproliferative agents
The invention provides novel, water-soluble 2-aminoimidazoline derivatives having general formula (i) as well as some precursors of formula (i), which are very potent inducers of g2/m cell cycle arrest. In treated tumor cells, compounds of formula (i) give gene expression profile distinct from known antimitotic agents.
10/16/14
20140309240
Derivatives of 1-(substituted sulfonyl)-2-aminoimidazoline as antitumor and antiproliferative agents
The invention provides novel, water-soluble 2-aminoimidazoline derivatives having general formula (i) as well as some precursors of formula (i), which are very potent inducers of g2/m cell cycle arrest. In treated tumor cells, compounds of formula (i) give gene expression profile distinct from known antimitotic agents.
10/16/14
20140309221
Method of inhibiting hamartoma tumor cells
Dimorpholinopyrimidines are useful for inhibiting growth or proliferation of hamartoma tumor cells. Because the dimorpholinopyrimidines inhibit the growth and proliferation of hamartoma tumor cells they are also useful in treating pten hamartoma tumor syndromes.
10/16/14
20140309195
Small molecules that promote skin regeneration
Provided herein are small molecules for the induction of fibroblast proliferation and increased secretion or production of proteins. The small molecules described herein can be used for the promotion of skin regeneration.
10/16/14
20140309165
Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
The invention provides 1,3-diphenylprop-2-en-1-one derivatives and pharmaceutical compositions comprising the same for treating liver disorders, in particular those requiring the reduction of plasma level of biochemical markers such as amino-transferases. The 1,3-diphenylprop-2-en-1-one derivatives of general formula (i) have hepatoprotective properties and can be used in methods for treating liver disorders involving the pathological disruption, inflammation, degeneration, and/or proliferation of liver cells, such as liver fibrosis or fatty liver disease..
10/16/14
20140308288
Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
An antibody of the invention interacts with human dr5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-dr5 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated.
10/16/14
20140308264
Vegf analogs and methods of use
Modified vegf proteins that inhibit vegf-mediated activation or proliferation of endothelial cells are disclosed. The analogs may be used to inhibit vegf-mediated activation of endothelial cells in angiogenesis-associated diseases such as cancer, inflammatory diseases, eye diseases, and skin disorders..
10/16/14
20140308258
Enhanced microbial strains for the prevention and treatment of methicillin-resistant staphylococcus aureus and methicillin-resistant staphylococcus epidermis infection
The present invention provides enhanced microorganisms useful for inhibiting and/or preventing the proliferation of pathogenic microorganisms such as methicillin-resistant staphylococcus aureus and methicillin-resistant staphylococcus epidermidis.. .
10/16/14
20140308255
Methods and compositions for regulation of cell aging, carcinogenesis and reprogramming
Compositions and methods described herein include somatic cells that are competent for reprogramming and malignant transformation and are characterized by a reduction of the levels of sp100 in the cells, cells having markers of pluripotent stem cells, and methods for preparing same. Methods for reversably regulating aging or reprogramming to pluripotency in a somatic cell involve modulating the expression of sp100 therein.
10/09/14
20140304093
Method and system to promote sales or services with social sales point
The present disclosure is directed towards small modules, web plugins, which may be placed on any influential content which simplify and promote sales by operating as a social sales point (ssp). Ssp's simplify sales by avoiding buyers engaging in any further searches or product comparisons.
10/09/14
20140303727
Device for ear drum repair
A device for use in the repair of an ear drum in a subject in need of such treatment, said device: having a tensile strength youngs modulus between approximately 12.5 and 40 mpa; comprising one or more membrane layers, wherein at least one membrane layer comprises a plurality of pores; and wherein the device can support proliferation, migration and/or adhesion of cells selected from the group comprising at least any one or more of: keratinocytes, fibroblasts, vascular cells, mucosal epithelial cells, and stem cells.. .
10/09/14
20140303212
Method for treating neurodegeneration using a p38mapk inhibitor
Ataxia-telangiectasia (a-t) is a progressive degenerative disorder that results in major neurological disability. In a-t patients, necropsy has revealed atrophy of all cerebellar cortical layers with extensive purkinje and granular cell loss.
10/09/14
20140303197
Methods of treating and preventing leukemia and other cancers of the blood and bone
The present invention relates to preventing and treating leukemia and other cancers of the blood and bone, as well as disorders of the blood, by inhibiting gut-derived serotonin. The inhibition of the gut-derived serotonin is accomplished by inhibiting tph1, an enzyme responsible for the production of gut-derived serotonin.
10/09/14
20140303162
Azabicyclo compound and salt thereof
It is intended to provide a novel azabicyclo compound which exhibits both hsp90 inhibitory activity and cell proliferation inhibitory effect. Specifically disclosed is a compound represented by the following general formula (i) or a salt thereof: wherein x1 represents ch or n; any one of x2, x3 and x4 represents n, and the others represent ch; any one or two of y1, y2, y3 and y4 represent c—r4, and the others are the same or different and represent ch or n; r1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from n, s and o; r2 represents an alkyl group having 1 to 6 carbon atoms, or the like; and r3 and r4 represent —co—r5 or the like..
10/09/14
20140303111
Compositions including triciribine and taxanes and methods of use thereof
This application relates to combination therapies including triciribine and related compounds and taxanes and compositions with reduced toxicity thr the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. .
10/09/14
20140303078
Modulation of pancreatic beta cell proliferation
Work described herein provides, in one embodiment, a method for increasing proliferation or replication of pancreatic beta cells in a subject in need thereof, comprising administering to said subject an effective amount of an agent that increases the level or activity of hepatocellular carcinoma-associated protein td26 (td26), thereby increasing proliferation or replication of pancreatic beta cells. Such an agent may function by, for example, increasing the level of active td26 in the subject or by increasing the functional activity of td26 in the subject..
10/09/14
20140302491
Ex vivo culture, proliferation and expansion of primary tissue organoids
Culture systems and methods for long term culture of mammalian tissues are provided. Tissues include but are not limited to lung alveolar tissue, stomach tissue, pancreas tissue, bladder tissue, liver tissue, and kidney tissue.
10/09/14
20140302057
Inhibitors of metastasis
The present invention relates to methods and compounds for treating or preventing cancer. Methods and compositions provided include including inhibiting or suppressing the development, maintenance, and proliferation of cancers, including blocking or inhibiting cancer cell metastasis..
10/09/14
20140302011
Compositions including triciribine and trastuzumab and methods of use thereof
This application relates to combination therapies including triciribine and related compounds and trastuzumab or a salt thereof and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. .
10/09/14
20140301943
Induction of thyroid iodide-handling gene expression in human cancers
Dual suppression of the map kinase and pi3k/akt pathways showed synergistic or greatly enhanced anti-melanoma cell effects, compared to suppression of a single pathway, including the inhibition of cell proliferation, transformation and invasion, induction of g0/g1 cell cycle arrest and, importantly, cell apoptosis. Remarkably, suppression of either pathway induces the expression of thyroid iodide-handling genes and dual suppression of the two pathways synergistically and robustly induces expression of these genes, accompanied by uptake of radioiodine in the cells.
10/02/14
20140296344
Polyunsaturated fatty acid monoglycerides, derivatives, and uses thereof
There are provided various polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds can be useful as cancer chemopreventive agents, cancer treating agent, inhibiting tumor growth or cell proliferation, reducing tumor growth or as radioenhencers for radiotherapy of cancer..
10/02/14
20140296312
Treatment of breast cancer
The disclosure describes the use of one or more compounds that fall within the scope of one or more of structural formulae i, ii, iii, iv, v, or vi for treating triple negative breast compounds useful for treating breast cancer include those compounds of formulae i, ii, iii, iv, v, or vi that inhibit proliferation of breast cancer cells and/or lead to the death of breast cancer cells, especially triple negative breast cancer.. .
10/02/14
20140296307
Potent analogues of the c-myc inhibitor 10074-g5 with improved cell permeability
The present invention relates compounds and compositions for interfering with the association of myc and max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of a cell.
10/02/14
20140296230
Dihydroquinazolinone analogues
Wherein the groups r1 to r4 and a1 to a5 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament..
10/02/14
20140296229
Indolinone analogues
Wherein the groups r1 to r4, a1 and a2 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament..
10/02/14
20140296156
Peptide based inhibition of capcna interaction in cancer
Peptides derived from cancer specific isoform of proliferating cell nuclear antigen (capcna, also known as cspcna) or from nmpcna-interacting proteins interfere with intracellular protein-protein interaction, thereby causing a reduction in the proliferative potential of cancer. These peptides serve as therapeutic compositions to reduce the proliferation of cancer cells and also augment existing chemotherapeutic methods..
10/02/14
20140296143
Angiotensin-(1-7) as a chemoprevention agent
Disclosed is the use of angiotensin-(1-7) peptide as an anti-cancer and chemoprevention therapeutic. Embodiments of the present invention comprise methods and compositions to prevent cancer or to reduce the risk of cancer in an individual comprising administering to the individual a pharmaceutically effective amount of an agonist for the angiotensin-(1-7) receptor to inhibit at least one of formation of a tumor (tumorigenesis), the proliferation of tumor cells, the growth of tumor cells, or metastasis of tumor cells in the individual.
10/02/14
20140296104
Genes differentially expressed by cumulus cells and assays using same to identify pregnancy competent oocytes
A genetic means of identifying “pregnancy competent” oocytes is provided. The means comprises detecting the level of expression of one or more genes that are expressed at characteristic levels (upregulated or downregulated) in cumulus cells derived from pregnancy competent oocytes.
10/02/14
20140295414
Methods and compositions for labeling nucleic acids
The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. In particular, the methods include a [3+2] cycloaddition between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent attached to a label.
10/02/14
20140294971
Cancer cell-inhibiting ceramic, process for producing cancer cell-inhibiting ceramic, method for treating bone tumor, and use of beta-tricalcium phosphate porous granules with particle size of 1 to 10 micrometer
Proliferation of cancer cells is effectively inhibited. Provided is a cancer cell-inhibiting ceramic containing a β-tricalcium phosphate porous granule with a particle size of 1 to 10 μm.
10/02/14
20140294957
Niclosamide for the treatment of cancer metastasis
The invention relates to niclosamide and derivates thereof, which effectively inhibit transcription of the s100a4 gene, resulting in inhibition and/or reduction of s100a4-induced cell motility, invasiveness, metastasis and proliferation of human cancer cells.. .
10/02/14
20140294931
Method and composition of thyroid hormone analogues and nanoformulations thereof for treating anti-inflammatory disorders
Thyroid hormone antagonists and their nanoparticle formulations (nanotetrac™ or nanotriac™) act at a cell surface receptor to block angiogenesis and tumor cell proliferation. The complex anti-angiogenic performs actions on specific cytokines and chemokines.
10/02/14
20140294912
Amorphous poly(d,l-lactide) coating
Implantable devices formed of or coated with a material that includes an amorphous poly(d,l-lactide) formed of a starting material such as meso-d,l-lactide are provided. The implantable device can be used for the treatment, mitigation, prevention, or inhibition of a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof..
10/02/14
20140294897
Potent lna oligonucleotides for the inhibition of hif-1a expression
The present disclosure relates to an lna oligonucleotide consisting of a sequence selected from the group consisting of 5′-(tx)gxgxcsasasgscsastscscstxgxt-3′ and 5′-(gx)txtxascstsgscscststscstxtxa-3′, wherein capital letters designate a beta-d-oxy-lna nucleotide analogue, small letters designate a 2-deoxynucleotide, underline designates either a beta-d-oxy-lna nucleotide analogue or a 2-deoxynucleotide, subscript “s” designates a phosphorothioate link between neighbouring nucleotides/lna nucleotide analogues, and subscript “x” designates either a phosphorothioate link or a phosphorodiester link between neighbouring nucleotides/lna nucleotide analogues, and wherein the sequence is optionally extended by up to five 2-deoxynucleotide units. The lna oligonucleotides are useful for modulating the expression of hypoxia-inducible factor-1a (hif-1a), e.g.
10/02/14
20140294855
Small molecule screening for mouse satellite cell proliferation
The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided is a method for repairing or regenerating a damaged muscle tissue of a subject..
09/25/14
20140288178
Inhibition of c-myc ubiquitination to prevent cancer initiation and progression
The present invention is directed to methods of inhibiting cancer cell proliferation, differentiation and/or survival. These methods involve the administration of fbw7 e3 ligase inhibitors to inhibit c-myc ubiquitination in cancerous cell populations, such as leukemic initiating cell populations, that are responsible for disease initiation and progression..
09/25/14
20140288162
Methods, compositions and screens for therapeutics for the treatment of synovial sarcoma
Methods and compositions are provided for treating human synovial sarcoma (ss). Also provided are screens to identify therapeutics for the treatment of synovial sarcoma.
09/25/14
20140288142
Nitric oxide donor compounds
The invention relates to nitric oxide donor compounds and their use for treating cardiovascular diseases, inflammation, pain, fever, gastrointestinal disorders, ophthalmic diseases, hepatic disorders, renal diseases, respiratory disorders, immunological diseases, bone metobolisms dysfunctions, central and peripheral nervous system diseases, sexual dysfunctions, infectious diseases, for the inhibition of platelet aggregation and platelet adhesion, for treating pathological conditions resulting from abnormal cell proliferation, vascular diseases. The invention also relates to compositions comprising at least one nitric oxide releasing compounds of the invention and composition comprising at least one nitric oxide releasing compounds according to the invention and at least one 15 therapeutic agent..
09/25/14
20140288070
Compounds and methods for kinase modulation, and indications therefor
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one raf protein kinase.
09/25/14
20140288032
Agents and devices for use in prevention of restenosis
Agents that inhibit or prevent restenosis are identified by assaying test agents in a battery of assays to measure the effect of the test agent on cell proliferation, thrombosis, tissue modeling, and inflammation. Treatment for restenosis is provided using compositions of the invention..


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Proliferation topics: Proliferation, Cell Proliferation, Differentiation, Cancer Cell, Antibodies, Progesterone, Specificity, Cancer Cells, Antimicrobial, Lymphocyte, Cell Differentiation, Homogeneous, Amino Acids, Wound Healing, Epithelial

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This listing is a sample listing of patent applications related to Proliferation for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Proliferation with additional patents listed. Browse our RSS directory or Search for other possible listings.
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