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Proliferation patents



      

This page is updated frequently with new Proliferation-related patent applications.




Date/App# patent app List of recent Proliferation-related patents
05/19/16
20160138027 
 Treatment of diseases and conditions associated with dysregulation of mammalian target of rapamycin complex 1 (mtorc1) patent thumbnailTreatment of diseases and conditions associated with dysregulation of mammalian target of rapamycin complex 1 (mtorc1)
Compositions and methods for treating diseases and conditions associated with dysregulation of mammalian target of rapamycin complex 1 (mtorc1) are disclosed. The invention is based in part on the discovery that protein mediator of amino acid signaling to mtor (mortor) is involved in amino acid-induced translocation of mtorc1 to lysosomes where mortor forms a signaling complex with mtorc1, ragulator, and rag gtpases, which controls protein synthesis.
The Board Of Trustees Of The Leland Stanford Junior University


05/19/16
20160137585 
 Compositions and methods for glucose transport inhibition patent thumbnailCompositions and methods for glucose transport inhibition
Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates.
Ohio University


05/19/16
20160136273 
 Compositions including triciribine and trastuzumab and methods of use thereof patent thumbnailCompositions including triciribine and trastuzumab and methods of use thereof
This application relates to combination therapies including triciribine and related compounds and trastuzumab or a salt thereof and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. .
University Of South Florida


05/19/16
20160136248 
 Methods and materials for modulating deubiquitinases and ubiquitinated polypeptides patent thumbnailMethods and materials for modulating deubiquitinases and ubiquitinated polypeptides
This document relates to methods and materials involved in modulating deubiquitinases (e.g., usp10 polypeptides) and/or ubiquitinated polypeptides (e.g., tumor suppressor polypeptides or mutant versions of tumor suppressor polypeptides). For example, methods and materials for increasing deubiquitinase (e.g., a usp10 polypeptide) expression or activity, methods and materials for decreasing deubiquitinase (e.g., a usp10 polypeptide) expression or activity, methods and materials for stabilizing tumor suppressor polypeptides (e.g., wild-type p53 polypeptides), methods and materials for de-stabilizing mutant versions of tumor suppressor polypeptides (e.g., mutant p53 polypeptides), and methods and materials for reducing cancer cell proliferation, increasing cancer cell apoptosis, and/or treating cancer (e.g., cancers having reduced levels of wild-type p53 polypeptides or cancers having increased levels of mutant p53 polypeptides) are provided.
Mayo Foundation For Medical Education And Research


05/19/16
20160136234 
 Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition patent thumbnailCompositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition
The described invention provides compositions and methods for reducing progression of a fibrosis in a tissue of a subject selected from liver, kidney or vascular fibrosis, the progression of the fibrosis being characterized by aberrant fibroblast proliferation and extracellular matrix deposition in the tissue. The method includes administering a therapeutic amount of a pharmaceutical composition containing a polypeptide having the amino acid sequence yaraaarqarakalarqlgvaa (seq id no: 1) or functional equivalent thereof, and a pharmaceutically acceptable carrier, wherein the therapeutic amount of the polypeptide is effective to reduce progression of the fibrosis, to treat remodeling of the tissue, or a combination thereof..
Moerae Matrix, Inc.


05/19/16
20160136228 
 Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof patent thumbnailCompositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
This application relates to combination therapies including triciribine and related compounds and bortezomib and derivatives thereof analogs and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. .
University Of South Florida


05/19/16
20160136164 
 Methods and compositions for the treatment of cancer and related hyperproliferative disorders patent thumbnailMethods and compositions for the treatment of cancer and related hyperproliferative disorders
The present invention relates to methods of treating a disease related to cell hyper-proliferation via administration of a therapeutically effective amount of a compound having a general tripartite structure a-b—c. In the tripartite structure a, b, and c are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein.
Baylor College Of Medicine


05/12/16
20160130637 
 Dual labeling methods for measuring cellular proliferation patent thumbnailDual labeling methods for measuring cellular proliferation
The present invention provides a method for measuring cellular nascent nucleic acid synthesis by dual pulse labeling of nucleic acid. The first pulse labeling of nucleic acid with a nucleoside analog allows establishment of a baseline nucleic acid synthesis rate.
Life Technologies Corporation


05/12/16
20160130269 
 7-azaindole derivatives patent thumbnail7-azaindole derivatives
Compounds of the formula (i) in which r, r1, r2 and r3 have the meanings indicated in claim 1, are inhibitors of pdk1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.. .
Merck Patent Gmbh


05/12/16
20160129109 
 Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer patent thumbnailUniversal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer
The present invention provides a universal, yet adaptable, anti-tag chimeric antigen receptor (at-car) system which provides t cells with the ability and specificity to recognize and kill target cells, such as tumor cells, that have been marked by tagged antibodies. As an example, αfitc-car-expressing t cells have been developed that specifically recognize various human cancer cells when those cells are bound by cancer-reactive fitc-labeled antibodies.
University Of Maryland, Baltimore


05/12/16
20160129069 

Method for inducing proliferation of dopaminergic cells


A method for inducing a proliferation of dopaminergic cells in a subject in need, comprising: administering a herbal medicinal composition to a subject in need, wherein the herbal medicinal composition comprises: ginseng radix, glycyrrhiza uralensis, zingiber officinale roscoe, cinnamomum cassia presl., and scutellariae radix.. .

05/12/16
20160129068 

Composition of plant extract and its pharmaceutical composition and application thereof


The present invention is related to a composition for relieving joint inflammation. The present invention is also related to a method for treatment of joint inflammation, comprising a step of administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition.
Caliway Biomedical Co., Ltd.


05/12/16
20160129051 

Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment


Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating tgf β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues.
Tissuetech, Inc.


05/12/16
20160129050 

Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition


Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating tgf β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues.
Tissuetech, Inc.


05/12/16
20160129049 

Purified amniotic membrane compositions and methods of use


Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating tgf β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues.
Tissuetech, Inc.


05/12/16
20160129047 

Conditioned medium from human adult liver stem cells and its use in the treatment of liver disorders


The invention relates to cell-free compositions obtained by culturing adult-derived human liver stem/progenitor cells (adhlsc) in cell culture medium and isolating the resulting conditioned medium (adhlsc-cm) that has advantageous property ties, such as anti-fibrotic effects. Adhlsc-cm, compositions based on adhlsc-cm, and other related and derived products, can be used in cell culture processes or as a medicament, more particularly for the treatment of diseases involving organ injury, organ failure, in organ or cell transplantation or the pathological disruption, inflammation, degeneration, and/or proliferation of cells within a tissue or an organ, in particular within liver..
UniversitÉ Catholique De Louvain


05/12/16
20160129032 

Receptor-type kinase modulators and methods of use


The present invention provides compounds for modulating receptor kinase activity, particularly ephrin and egfr, and methods of treating diseases mediated by receptor kinase activity utilizing the compounds and pharmaceutical compositions thereof. Diseases mediated by receptor kinase activity include, but are not limited to, diseases characterized in part by abnormal levels of cell proliferation (i.e.
Symphony Evolution, Inc.


05/12/16
20160128991 

Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof


Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, alzheimer's disease and osteoarthritis), the modulation of cellular events mediated by wnt pathway signaling, as well as genetic diseases due to mutations in wnt signaling components.
Samumed, Llc


05/05/16
20160125127 

Identification of minimal combinations of oncoproteins in notch pathway to suppress human glioblastoma


The invention is directed to in-silico method to identify combinatorial oncoprotiens as potential drug targets or combinatorial oncoprotien biomarkers in notch pathway to suppress the human glioblastoma proliferation.. .
Council Of Scientific & Industrial Research


05/05/16
20160122702 

Method for determining cell state and autoanalyzer using said method


There is provided a method for noninvasively evaluating the cell state (proliferation, multi-layering, and differentiation) of a cell sheet as a mimic tissue at the time of culturing the cell sheet. The method is characterized in that an analysis of an amino acid is conducted with the use of the culture supernatant of a cell sheet to monitor a change in the concentration of any amino acid selected from a group of 5-species of amino acids (ile, val, ser, leu, and ala), thereby making a determination..
Hitachi High-technologies Corporation


05/05/16
20160122434 

Antagonist of the btla/hvem interaction for use in therapy


The present invention relates to an antagonist of the btla/hvem interaction for use in therapy, wherein said antagonist increases the proliferation of vγ9vδ2 t cells.. .
Centre National De La Recherche Scientifique-cnrs


05/05/16
20160122426 

Anti-vegf antibody, and pharmaceutical composition for preventing, diagnosing or treating cancer or angiogenesis-related diseases, containing same


A novel anti-vascular endothelial growth factor (vegf) antibody having a strong binding affinity for vegf and capable of inhibiting in vivo tumor growth and a composition for the treatment of cancer, containing the same. The antibody shows a remarkable binding property to human and mouse vegf, suppresses the proliferation and permeability of a human umbilical vein endothelial cell (huvec) and inhibits tumor growth, and thus can be useful as an antibody for the treatment of cancer..
Dong-a St Co., Ltd


05/05/16
20160122402 

Retro polypeptides for activation immunity to cancer and viral infection


A polypeptide that drives t cell proliferation and differentiation, and methods and agents for modulating the expression and/or function of the polypeptide. Agents that up regulate the expression and/or function of the polypeptide are useful in the treatment or prevention of diseases and disorders that would benefit from stimulation of t cell proliferation and/or differentiation, such as cancer and chronic viral infections.
Imperial Innovations Limited


05/05/16
20160122390 

A biomimetic peptide and biodegradable delivery platform for the treatment of angiogenesis- and lymphangiogenesis-dependent diseases


Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, an isolated peptide comprising the amino acid sequence lrrfstapfafidindvinf, which exhibits anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models is disclosed.
The Johns Hopkins University


05/05/16
20160120979 

Method of applying a composition and pharmaceutical composition with a regimen of administering it


A method applying a composition to a human or non-human individual or to an object or a surface area and a pharmaceutical composition with a regimen of administering it to a human or non-human individual is provided. The composition includes an active chemical component for killing of or retarding proliferation of target cells including pathogens, infected cells and cancer cells.

05/05/16
20160120934 

Lung injury repair compositions and methods


The present invention provides a pharmaceutical composition comprising protein kinase c zeta (pkc-ζ) inhibitor and therapeutic methods for preventing or treating a pathological condition or symptom or for inducing proliferation of lung progenitor cells in a mammal by administering the pkc-ζ inhibitor.. .
University Of Iowa Research Foundation


05/05/16
20160120875 

Substituted (e)-n'-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors


Methods of treatment of disorders of uncontrolled cellular proliferation, including cancer, by administering substituted (e)-n′-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds to mammals in need thereof.. .
University Of Utah Research Foundation


05/05/16
20160120874 

Agents for treating multiple myeloma


The present invention relates to the use of compounds of a cannabinoid nature for inhibiting viability with increasing doses of myeloma cell lines. Furthermore, said compounds have been shown not to affect cd34+ cells (normal hematopoietic progenitors) in terms of viability and proliferation.
Servicio Andaluz De Salud


04/28/16
20160115559 

Bacterium belonging to genus lactobacillus


A lactobacillus pentosus tua4337l strain (accession number: nite bp-1479), characterized in that the strain has proliferation ability in the small intestines and/or the large intestine, and preferably the small intestines, after having survived in the intestinal tract. Since the lactic acid bacteria of the present invention have proliferation ability in the intestinal tract, when ingested in the body, the lactic acid bacteria survive to the intestinal tract and proliferate, whereby the fat absorption can be continuously blocked, and the weight gains can be effectively blocked, so that the lactic acid bacteria can be suitably used for the purposes of dieting effects..
Suntory Holdings Limited


04/28/16
20160115251 

Heparan sulphates


A novel class of structurally and functionally related isolated heparan sulphate is disclosed. The novel class of heparan sulphates has been found to bind fgf2 and enhance the proliferation of stem cells whilst maintaining their pluripotency/multipotency..
Agency For Science, Technology And Research


04/28/16
20160115202 

Chemical synthesis and screening of bicyclic peptide libraries


Disclosed herein are bicyclic peptide compounds, compositions comprising same, methods for making same, and libraries comprising same. The disclosed compounds, in various aspects, are useful for treating a variety of disorders, including inflammatory disorders, autoimmune disorders, and disorders of uncontrolled cellular proliferation.
Ohio State Innovation Foundation


04/28/16
20160115168 

Novel fused pyrimidine compound or salt thereof


Provided is a novel compound having btk inhibitory action and a cell proliferation suppressing effect. Also provided is a medicine useful for the prevention and/or treatment of a disease associated with btk, particularly cancer, based on btk inhibitory action.
Taiho Pharmaceutical Co., Ltd.


04/28/16
20160115167 

Bmp inhibitors and methods of use thereof


The present invention provides small molecule inhibitors of bmp signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with bmp signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.
The General Hospital Corporation


04/28/16
20160113958 

Modulators of adp-dependent glucokinase (adpgk) and glycerol-3-phosphate dehydrogenase (gpd2) for therapy


Described are compounds capable of modulating (a) the biological activity of adp-dependent glucokinase (adpgk) and/or glycerol-3-phosphate dehydrogenase (gpd2) or (b) the expression of the gene encoding adpgk or gpd2 for use in treating a disease (a) associated with aberrant cell proliferation, e.g., a neoplasm, or (b) of the immune system, e.g., an autoimmune disease.. .
Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Recht


04/28/16
20160113955 

Compositions and methods for immunotherapy


The present invention provides novel immunotherapeutic compositions and methods useful for treating or preventing microbial infections, weakened immune systems, diseases in which cells have become obligately anerobic and cellular proliferative disorders including cancer. The immunotherapeutics herein use benzaldehyde derivatives, precursors and intermediaries alone or in combination with additional therapeutic agents to stimulate the immune system and inhibit cellular proliferation.

04/21/16
20160110763 

Extracting product purchase information from electronic messages


Improved systems and methods for extracting product purchase information from electronic messages transmitted between physical network nodes to convey product purchase information to designated recipients. These examples provide a product purchase information extraction service that is able to extract product purchase information from electronic messages with high precision across a wide variety of electronic message formats and thereby solve the practical problems that have arisen as a result of the proliferation of different electronic message formats used by individual merchants and across different merchants and different languages.

04/21/16
20160110762 

Extracting product purchase information from electronic messages


Improved systems and methods for extracting product purchase information from electronic messages transmitted between physical network nodes to convey product purchase information to designated recipients. These examples provide a product purchase information extraction service that is able to extract product purchase information from electronic messages with high precision across a wide variety of electronic message formats and thereby solve the practical problems that have arisen as a result of the proliferation of different electronic message formats used by individual merchants and across different merchants and different languages.

04/21/16
20160108365 

Maintenance of genomic stability in cultured stem cells


The present application relates to methods and compositions for the generation of therapeutic cells having reduced incidence of karyotypic abnormalities. In several embodiments cardiac stem cells are cultured in an antioxidant-supplemented media that reduces levels of reactive oxygen species, but does not down regulate dna repair mechanisms.

04/21/16
20160108086 

Peptide stimulator of cell survival and proliferation


The invention provides a novel peptide, and derivatives thereof, which is stable in aqueous solution and which stimulates proliferation and survival of endothelial cells and/or fibroblasts. The present peptide can be used at least to promote the s phase of the cell cycle, to stimulate production of extracellular matrix proteins, to reduce apoptosis, to inhibit production of reactive oxygen species and/or to reduce or prevent damage to cell integrity or morphology under stress conditions of serum deprivation..

04/21/16
20160108042 

Indolizino[3,2-c]quinoline derivatives, pharmaceutically acceptable salt thereof, preparation method thereof and pharmaceutical composition for treatment of cystic fibrosis containing the same as active ingredient


Provided are an indolizino[3,2-c]quinoline derivative, pharmaceutically acceptable salt thereof, and a method for preparing the same. The indolizino[3,2-c]quinoline derivative, pharmaceutically acceptable salt thereof may function as an agonist of cystic fibrosis conductance transmembrane regulator, and thus may be useful for an agent for preventing or treating diseases caused by degradation of activity of cystic fibrosis conductance transmembrane regulator and for a pharmaceutical composition for stimulating proliferation of stem cells..

04/14/16
20160103724 

System and detecting and predicting anomalies based on analysis of time-series data


Provided are a system and method for detecting and predicting anomalies based on analysis of time-series data. According to an embodiment of the present disclosure, an abnormality detecting and predicting system includes a database configured to store past case data related to a state of a monitored object; a data collector configured to collect time-series status information of the monitored object; an abnormality detector configured to compare the status information with an abnormality detecting reference in a preset detecting interval and detect an occurrence of an abnormality of the monitored object; a similar case selector configured to select a similar case having a highest degree of similarity to the status information among the past case data when the occurrence of an abnormality is detected by the abnormality detector; and a predictor configured to predict proliferation or diminishing of a detected abnormality using the similar case and an abnormality proliferation predicting reference..

04/14/16
20160102132 

Monomeric recombinant mhc molecules useful for manipulation of antigen-specific t-cells


The present invention provides, in particular embodiments, for modified recombinant t cell receptor (tcr) ligands (rtls) comprising a mhc class i or mhc class ii component. The modified rtls have redesigned surface features that preclude or reduce aggregation, wherein the modified molecules retain the ability to bind ag-peptides, target antigen-specific t cells, inhibit t cell proliferation in an ag-specific manner and have utility to treat, inter alia, autoimmune disease and other conditions mediated by antigen-specific t cells in vivo..

04/14/16
20160102067 

Oxiran amines


Disclosed herein are oxiran amines useful for the treatment of a variety of diseases. The oxiran amines are useful in the manufacture of pharmaceutical compositions.

04/14/16
20160101390 

Modification of membranes with polydopamine and silver nanoparticles formed in situ to mitigate biofouling


The present invention is directed to a method for modifying polymeric membranes to mitigate biofouling. More particularly, dopamine powder is dissolved in a buffer solution, and the membrane surface is exposed to the solution, resulting in the formation of a polydopamine thin film on the membrane.

04/14/16
20160101156 

Composition containing palmultang extract for promoting proliferation of stem cells derived from bone marrow


The present invention relates to a composition for promoting the proliferation of stem cells derived from bone marrow using a palmultang extract, and more specifically, to a composition for promoting the proliferation of stern cells derived from bone marrow by administering a granulocyte colony-stimulating factor to a subject and then administering the palmultang extract to the subject. The composition of the present invention remarkably reduces side effects, such as enlargement of the spleen, which are caused by the administration of g-csf alone for proliferation and differentiation of the stern cells, through administration in combination with the palmultang extract, thereby further promoting the proliferation and differentiation of stem cells..

04/14/16
20160101067 

Supramolecular complexes of polyanionic polymers and spermidine in tissue maintenance and repair


Supramolecular complexes are formed by polyanionic polymers and spermidine having a ratio of anionic equivalents ranging from 101:1 to 107:1 eq/eq, more preferably from 102:1 to 104:1 eq/eq, whose components are linked by non-covalent, ionic interactions. The supramolecular complexes are exhibit high potency in eliciting fibroblast proliferation.

04/14/16
20160100934 

Nanomaterials for the integration of soft into hard tissue


Nanocomposite materials are provided for attaching soft tissue to hard tissue of a mammalian subject. The materials include a biodegradable polymer network suffused with mineral nanoparticles.

04/07/16
20160096868 

Mussel-inspired bioactive surface coating composition generating silica nanoparticles


The present invention relates to a fusion protein comprising a mussel adhesive protein and a silica-binding peptide linked to the mussel adhesive protein, a silica nanoparticle a silica connected to the fusion protein, a fusion protein-silica nanoparticle complex comprising the silica nanoparticle having bioactivity and adhesiveness for cell proliferation and accelerating the differentiation, a surface coating composition including the complex, its use, and a method of coating a surface using the surface coating composition.. .
Postech Academy-industry Foundation


04/07/16
20160096837 

Substituted 1,2,3,4-tetrahydropyrido[3,4-e] pyrrolo[1,2-a]pyrimidines as kinase inhibitors


The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.. .
Allergan, Inc.


04/07/16
20160096832 

Kinase inhibitors


The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.. .
Allergan, Inc.


04/07/16
20160095815 

Substance for restoring normal co-expression and interaction between the lox and nrage proteins


The invention relates to the use of a substance for restoring normal co-expression and interaction between the lox and nrage proteins. The invention relates in particular to the use of an effective amount of at least one substance that modulates the expression and/or activity of the lox of seq id no: 1 and/or that modulates the expression and/or activity of the nrage of seq id no: 2 for modulating the interaction between the lox and nrage proteins to regulate the balance between the cellular proliferation, differentiation and apoptosis, particularly in cases where the balance between these phenomena is disturbed, and especially in cases where the interaction between lox and nrage is absent or altered.
Université Claude Bernard Lyon 1


03/31/16
20160090420 

Antagonist of the btla/hvem interaction for use in therapy


Antagonist of the btla/hvem interaction for use in therapy the present invention relates to an antagonist of the btla/hvem interaction for use in therapy, wherein said antagonist increases the proliferation of vγ9vδ2 t cells.. .
Centre National De La Recherche Scintifique- Cnrs


03/31/16
20160090380 

2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof


Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the wnt pathway and/or of one or more of wnt signaling components.
Samumed, Llc


03/31/16
20160089395 

Compositions and methods for altering human cutaneous microbiome to increase growth of staphylococcus epidermidis and reduce staphylococcus aureus proliferation


An antibacterial composition comprising arginine bicarbonate, zinc carbonate, preferably arginine bicarbonate and zinc carbonate (abzc), in combination, plus one or more physiologically acceptable excipients, administered for the modification of cutaneous microfloras, generally to inhibit the growth of pathogenic staphylococcus aureus bacteria by promoting the growth of non-pathogenic staphylococcus epidermidis bacteria.. .
The Research Foundation For The State University Of New York


03/31/16
20160089319 

Actives for stimulating differentiation of keratinocytes to lighten hyperpigmented skin


A method is provided for identifying a material having an efficacy for reducing color contrast between a hyperpigmented skin lesion and skin surrounding the hyperpigmented skin lesion without directly affecting melanocytes or melanogenesis. The method includes the steps of applying a composition containing a material to be tested to the hyperpigmented skin lesion; and after an interval of time, observing whether the composition has effected at least one of inhibiting proliferation of keratinocytes, stimulating differentiation of keratinocytes, and improving compressive deformation of dermal papillae, in a basal layer of epidermis in the hyperpigmented lesion of skin..
Elc Management Llc


03/24/16
20160083776 

Methods for measuring polymerase activity useful for sensitive, quantitative measurements of any polymerase extension activity and for determining the presence of viable cells


A novel, highly sensitive, quantitative and rapid dpe-pcr assay is disclosed that can be used to enumerate prokaryotic cells when presenting a purified or selected cell type and that has the capability to reproducibly measure dna polymerase extension activity from less than 10 cfu of bacteria via coupling to bead lysis. Also disclosed is the potential for the dpe-pcr assay of the invention to universally detect microbes by testing a panel of microorganisms comprised of gram-negative bacteria, gram-positive bacteria and candida species.
Zeus Scientific, Inc.


03/24/16
20160083442 

Inhibitors of the t cell-specific alternative p38 activation pathway and methods of use


In t lymphocytes, p38 mitogen activated protein kinase (mapk) can be activated through an alternative pathway that involves phosphorylation at tyrosine 323. Disclosed herein is the identification of a minimal region of the growth arrest and dna damage-inducible alpha (gadd45α) protein that is required for binding to and inhibition of tyrosine 323-phosphorylated p38 in t cells.
The U.s.a, As Represented By The Secretary Department Of Health And Human Services


03/24/16
20160083441 

Development of protein-based biotherapeutics that penetrate cell-membrane and induce anti-cancer effect - cell-permeable trefoil factor 1 (cp-tff1) in gastrointestinal track (git) cancer, polynucleotides encoding the same, and anti-cancer compositions comprising the same


The present study investigated the use of macromolecule intracellular transduction technology (mitt) to deliver biologically active tff1 protein into gastric cancer cells both in vitro and in vivo. Proteins engineered to enter cancer cells are supposed to suppress cell proliferation and survival, consistent with its role as a tumor suppressor.
Cellivery Therapeutics, Inc.


03/24/16
20160083421 

Compunds for enzyme inhibition


Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of n-terminal nucleophile (ntn) hydrolases associated with the proteasome. The peptide-based compounds include an epoxide or aziridine, and functionalization at the n-terminus.
Onyx Therapeutics, Inc.


03/24/16
20160082067 

Method for treatment of prostatic hyperplasia and/or ameliorating urinary disturbance with banana flower extract


The present invention provides a method for treatment of prostatic hyperplasia with banana flower extract. Such banana flower extract can suppress the proliferation of prostate cells and their ability to synthesize dihydrotestosterone.
Tci Co., Ltd.


03/17/16
20160075997 

Kit of medium of inducing and amplifying hematopoietic stem cells


A kit of medium of inducing and amplifying hematopoietic stem cells, the kit includes medium of inducing and amplifying hematopoietic stem cell, and the medium of inducing and amplifying hematopoietic stem cell includes cell proliferation factors and cell differentiation inhibitors needed in proliferation of hematopoietic stem cells, and the formula of the medium of inducing and amplifying hematopoietic stem cell is: 80-100% (v/v) dmem/f12 basic medium, 0-1 μg/ml sonic hedgehog, 0-1 μg/ml delta1, 0-1 μg/ml flt3l, 0-1 μg/ml igfbp, 0-1 μg/ml scf, 0-1 μg/ml, angiopoietin, 0-1 μg/ml tpo, 0-1 μg/ml mbp, 0-1 μg/ml lif, 0-1 μg/ml tgf-β, 0-100 mm mtepa, and 1-5 mm nac.. .
Beijing Ginkgo Bioscience Co., Ltd.


03/17/16
20160075755 

Immunosuppressive tgf-ß signal converter


Embodiments of the disclosure concern cell therapy methods and compositions utilizing cells expressing at least a chimeric tgfβ receptor including the exodomain of a tgfβii receptor and an endodomain that is not from tgfβ receptor, thereby converting the negative signal of tgfβ for t cell proliferation into a t cell activation signal. In at least certain aspects, cells harboring the chimeric tgfβ receptor also harbor one or more chimeric antigen receptors..
Baylor College Of Medicine


03/17/16
20160075730 

New morpholinyl anthracycline derivatives


The present invention relates to new morpholinyl anthracycline derivatives which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them..
Nerviano Medical Sciences S.r.l.


03/17/16
20160075708 

Anti-angiogenesis compound, intermediate and use thereof


Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula i, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting vegfr2.
Zhongshan Ophthalmic Center, Sun Yat-sen University


03/17/16
20160075701 

2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof


Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the wnt pathway and/or of one or more of wnt signaling components.
Samumed, Llc


03/17/16
20160075662 

Indazolyl- and indolyl-benzamide derivatives


Useful in the treatment and/or prevention of diseases and/or conditions related to cell proliferation, such as cancer, infection, inflammation and inflammation-associated disorders, and conditions associated with angiogenesis.. .



Proliferation topics: Proliferation, Cell Proliferation, Differentiation, Cancer Cell, Antibodies, Progesterone, Specificity, Cancer Cells, Antimicrobial, Lymphocyte, Cell Differentiation, Homogeneous, Amino Acids, Wound Healing, Epithelial

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