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Proliferation patents

      

This page is updated frequently with new Proliferation-related patent applications.




Date/App# patent app List of recent Proliferation-related patents
08/18/16
20160237425 
 Pri-mirna libraries and methods for making and using pri-mirna libraries patent thumbnailPri-mirna libraries and methods for making and using pri-mirna libraries
Provided are methods for the design, preparation, and use of non-native pri-micrornas (pri-mirnas), pri-microrna (pri-mirna) scaffolds, and libraries of non-native pri-mirnas employing pri-mirna scaffolds. Also provided are methods for identifying non-native pri-mirnas, combinations of two or more non-native pri-mirnas, and mirnas derived from the processing of such non-native pri-mirnas, which mirnas exhibit one or more desired functional activities.

08/18/16
20160237139 
 Chimeric antigen receptor patent thumbnailChimeric antigen receptor
The present invention provides a chimeric antigen receptor (car) comprising: (i) a b cell maturation antigen (bcma)-binding domain which comprises at least part of a proliferation-inducing ligand (april); (ii) a spacer domain (iii) a transmembrane domain; and (iv) an intracellular t cell signaling domain. The invention also provides the use of such a t-cell expressing such a car in the treatment of plasma-cell mediated diseases, such as multiple myeloma..
Ucl Business Plc


08/18/16
20160235795 
 Therapy for promoting cell growth patent thumbnailTherapy for promoting cell growth
There is disclosed the use of a composition for promoting neuronal growth of neurons in tissues of the central or peripheral nervous system. There is also disclosed a method for inducing proliferation or differentiation of neuronal cells..
Moleac Pte. Ltd.


08/11/16
20160230143 
 Chemically defined culture medium for stem cell maintenance and differentiation patent thumbnailChemically defined culture medium for stem cell maintenance and differentiation
The present invention is directed to a low protein medium for the culture of pluripotent stem cells comprising one or more polysaccharides. The medium of the present invention can support cell culture objectives, for example cell survival, maintenance, passaging, proliferation, pluripotency, cloning, differentiation and induced pluripotent stem (ips) cell derivation..
The U.s.a., As Represented By The Secretary, Department Of Health & Human Services


08/11/16
20160229892 
 Cyclic peptide conjugates and methods of use patent thumbnailCyclic peptide conjugates and methods of use
The present invention concerns cyclic compounds, compositions comprising the cyclic compounds, linkers, a method of preparing a carrying agent:cyclic compound adduct, a method for treating disorders such as proliferation disorders (e.g., malignancies), bone deficiency diseases, and autoimmune diseases, and a method for suppressing the growth of, or inducing apoptosis in, cells (e.g., malignant cells).. .
Modulation Therapeutics


08/11/16
20160229867 
 Thieno[2,3-e]indole derivatives as new antitumor agents patent thumbnailThieno[2,3-e]indole derivatives as new antitumor agents
The present invention relates to a novel class of alkylating agents comprising a thieno[2,3-e]indole moiety tethered to a dna-binding moiety, which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical composition containing them.
Nerviano Medical Sciences S.r.l.


08/11/16
20160228722 
 Alternative magnetic stimulating system for preventing or treating brain tumor growth patent thumbnailAlternative magnetic stimulating system for preventing or treating brain tumor growth
Disclosed herein is a bidirectional alternating application system for preventing or treating a brain tumor caused by malignant glioma cells in animals. The bidirectional alternating magnetic field application system can apply a magnetic field having weak intensity and low frequency to patients in need of the prevention or treatment of brain tumor to thereby specifically inhibit the proliferation and mobility of glioma cells without causing any damage to normal cells.
Sangji University Industry Academic Cooperation Foundation


08/11/16
20160228610 
 Tissue engineering using progenitor cells to catalyze tissue formation by primary cells patent thumbnailTissue engineering using progenitor cells to catalyze tissue formation by primary cells
Methods of regenerating tissue using progenitor cells in combination with primary cells from a target tissue are disclosed. The progenitor cells catalyze proliferation and tissue production by primary cells allowing the use of fewer primary cells from a target tissue for effective tissue regeneration.
The Board Of Trustees Of The Leland Stanford Junior University


08/11/16
20160228511 
 Inhibition of the tumorigenic potential of tumor stem cells by lif and bmps patent thumbnailInhibition of the tumorigenic potential of tumor stem cells by lif and bmps
The present disclosure includes methods and compositions for the treatment or prevention of diseases and disorders characterized by excessive or misregulated cellular proliferations, including methods for the treatment of tumors. The methods involve the use of pharmaceutical compositions comprising at least one agent selected from the group consisting of a lif preparation, a bmp preparation, a bmpr signalling activator, and a lifr signalling activator.
Stemgen S.p.a.


08/11/16
20160228506 
 Compositions and formulations for prevention and reduction of tumorigenesis, cancer cell proliferation and invasion, and methods of production and use thereof in cancer treatment patent thumbnailCompositions and formulations for prevention and reduction of tumorigenesis, cancer cell proliferation and invasion, and methods of production and use thereof in cancer treatment
Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations..
Pronutria, Inc.


08/04/16
20160222352 

Use of cardiotrophin to modulate stem cell proliferation


Methods of promoting stem cell proliferation by contacting the cells with cardiotrophin-1 (ct-1) are provided. The methods may further include contacting the stem cells with one or more stem cell modulators that promote differentiation of the stem cells.
Ottawa Hospital Research Institute


08/04/16
20160222337 

Method for proliferation of cells within a bioreactor using a disposable pumphead and filter assembly


A method for promoting biological activity uses a filter system to increase cell production of a fed batch bioreactor. The filter system cycles bioreactor fluid through a hollow fiber tangential flow filter which separates metabolic wastes (as well as proteins) from cells produced in bioreactor and returned to fed batch bioreactor, improving cell production in the fed batch bioreactor.

08/04/16
20160222100 

Method of treating glioma


Methods of treating glioma are provided. Aspects of the invention include administering a therapeutically-effective amount of an agent that inhibits the activity of one or more neuronal activity-regulated proteins selected from: neuroligin-3, brain-derived neurotrophic factor (bdnf), or brevican, to a patient with a glioma.
The Board Of Trustees Of The Leland Stanford Junior University


08/04/16
20160222074 

Alpha-fetoprotein "ring and tail" peptides


The invention relates to compounds that are analogs of a cyclic peptide, cyclo[ektovnogn], afpep, that has anti-estrotrophic activity. The analogs of the invention include peptides and peptidomimetics that inhibit estrogen receptor-dependent cell proliferation.
Albany Medical College


08/04/16
20160222057 

Compounds for proteasome enzyme inhibition


Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of n-terminal nucleophile (ntn) hydrolases. The activities of those ntn having multiple activities can be differentially inhibited by the compounds described.
Onyx Therapeutics, Inc.


08/04/16
20160222014 

Compounds for regulating fak and/or src pathways


The present application provides novel optionally substituted fused pyridine and pyrimidine bicyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds.
Asana Biosciences, Llc


08/04/16
20160220631 

Methods of modulating erythropoiesis with arginine vasopressin receptor 1b molecules


Disclosed are methods of modulating erythropoiesis with arginine vasopressin receptor 1b (avpr1b) molecules, such as avpr1b agonists or antagonists. In one example, a method of stimulating erythropoiesis is disclosed including administering an effective amount of an avpr1b stimulatory molecule to a subject in need thereof, thereby stimulating erythropoiesis.
The Usa, As Represented By The Secretary, Departm- Ent Of Health And Human Service


08/04/16
20160220627 

Extracts of curcuma amada and uses thereof


The invention concerns carbon dioxide extracts of curcuma amada (mango ginger), including supercritical carbon dioxide extracts of c. Amada; methods for their production; compositions comprising the extracts; methods for treating or delaying the onset of conditions such as cell proliferation disorder (e.g., cancer), inflammation, infection, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hyperglycemia, platelet hyper-aggregation, immune disorder such as autoimmune disorder, or neurodegenerative condition; and methods for inhibiting expression of bcl-2, bak, and p53 genes; inhibiting expression of the cox-2 and nf-kb genes, inhibiting production of phosphorylated target of rapamycin (tor), modulating amp-activated protein kinase (ampk), inhibiting protein kinase b (akt) signaling, modulating the ras/raf/mek/erk signaling pathway, and modulating the ras/pi3k/pten/akt/mtor signaling pathway.
Flavex Naturextrakte Gmbh


08/04/16
20160220580 

Small molecule screening for mouse satellite cell proliferation


The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject..
President And Fellows Of Harvard College


08/04/16
20160220569 

Cdk4/6 inhibitor dosage formulations for the protection of hematopoietic stem and progenitor cells during chemotherapy


This invention is in the area of dosage formulations and methods of administering a cdk4/6 inhibitor for the transient protection of healthy cells, and in particular hematopoietic stem and progenitor cells (hspc), from damage associated with dna damaging chemotherapeutic agents in subjects undergoing dna damaging chemotherapeutic therapies for the treatment of proliferative disorders. In one aspect, improved protection of healthy cells is disclosed using a dosage that provides desirable pharmacokinetic and pharmacodynamic characteristics, including auc, tmax, cmax, dosage-corrected auc, and dosage-corrected cmax.
G1 Therapeutics, Inc.


07/28/16
20160215353 

Translocation and mutant ros kinase in human non-small cell lung carcinoma


In accordance with the invention, a novel gene translocation, (5q32, 6q22), in human non-small cell lung carcinoma (nsclc) that results in a fusion proteins combining part of cd74 with proto-oncogene tyrosine protein kinase ros precursor (ros) kinase has now been identified. The cd74-ros fusion protein is anticipated to drive the proliferation and survival of a subgroup of nsclc tumors.
Cell Signaling Technology, Inc.


07/28/16
20160215259 

Method of preparing induced neural stem cells reprogrammed from non-neuronal cells using hmga2


The method of producing the induced neural stem cells according to the present invention enables preparation of the induced neural stem cells from non-neuronal cells using only two inducing factors of sox2 and hmga2. Therefore, the method of the present invention can prepare induced neural stem cells in a more efficient manner than the conventional methods, which use four or five inducing factors.

07/28/16
20160215250 

Pluripotent tissue harvester and methods of manufacture thereof


Disclosed herein is a tissue harvester comprising a substrate having an airfoil shape; and a textured surface disposed upon the substrate, where the textured surface comprises a spatial array of nanometer or micrometer sized pillars of varying cross-sections. Disclosed herein too is method comprising disposing upon a substrate a textured surface; where the substrate has an airfoil shape and where the textured surface where the textured surface comprises nanometer or micrometer sized pillars; contacting the tissue harvester with biological cells whose proliferation under different conditions is desired; and disposing the tissue harvester in a flow field such that cells disposed on the tissue harvester at different locations may experience different flow fields..
University Of Florida Research Foundation, Inc.


07/28/16
20160215059 

Icos binding proteins


The present invention relates to an icos binding protein, or antigen binding portion thereof that is an agonist human icos and does not induce complement, adcc, or cdc when placed in contact with a t cell in vivo and methods of treating cancer, infectious disease and/or sepsis with said icos binding protein or antigen binding portion thereof. Further the icos binding proteins or antigen binding portions thereof of the present invention are capable of activating a t cell when placed in contact with said t cell; stimulating t cell proliferation when placed in contact with said t cell and/or inducing cytokine production when placed in contact with said t cell.
Glaxosmithkline Intellectual Property Development Limited


07/28/16
20160215056 

Human immune therapies using a cd27 agonist alone or in combination with other immune modulators


Methods of inducing t cell proliferation and expansion in vivo for treating conditions wherein antigen-specific t cell immune response are therapeutically desirable such as cancer, infection, inflammation, allergy and autoimmunity and for enhancing the efficacy of vaccines are provided. These methods comprise the administration of at least one cd27 agonist, preferably an agonistic cd27 antibody, alone or in association with another moiety such as immune stimulant or immune modulator such as an anti-cd40, ox-40, 4-1bb, or ctla-4 antibody or an agent that depletes regulatory cells, or a cytokine.
University Of Southampton


07/28/16
20160215042 

Methods for modulating immune responses during chronic immune conditions by targeting metallothioneins


Described herein are novel compositions comprising mt1 and/or mt2 modulators (i.e., inhibitors or activators), and methods using these agents for targeting different t-cell populations, for example, type 1 regulatory (tr1) cd4+ cells and exhausted cd8+ t-cells cells. Aspects of the invention relate to inhibitors of mt1 and/or mt2 to increase the differentiation of cd4+ cell trl1 cd4+ cells and increase in the activity of tr1 cells, e.g., to increase il-10 production.
The Brigham And Women's Hospital, Inc.


07/28/16
20160214994 

Fused pyrimidine compound, intermediate, preparation method therefor, and composition and application thereof


Disclosed are a fused pyrimidine compound, an intermediate, a preparation method therefor, and a composition and an application thereof. The present invention provides a fused pyrimidine compound shown in formula i, pharmaceutically acceptable salt, hydrate, solvate, and an optical isomer or prodrug of the compound.
Shanghai Yingli Pharmaceutical Co., Ltd


07/28/16
20160213911 

Antimicrobial inserts for stopcock medical connectors


Various embodiments of an antimicrobial insert for a stopcock medical connector are provided. More specifically, the present invention relates to an antimicrobial insert that is seated within at least a portion of the annular bore of the connector's tap, wherein fluid within the annular bore contacts the antimicrobial insert, thereby preventing microbial proliferation within the stopcock medical connector..
Becton, Dickinson And Company


07/28/16
20160213634 

Carcinoma diagnosis and treatment, based on odc1 genotype


The present invention provides methods and kits a) for predicting colorectal cancer patient survival, as well as the survival of patients harboring other invasive cancers where cellular proliferation and carcinogenesis is linked, in part, to high levels of odc activity and increased cellular polyamine contents, and b) for selecting the corresponding treatment options for such patients based on the allelic nucleotide sequence or snp at position +316 of the odc1 promoter gene as well as cancer treatment methods, in each case, which include the determination of the odc1 promoter +316 position genotype, as a means to guide treatment selection.. .
The Regents Of The University Of California, A California Corporation


07/28/16
20160213013 

Use of probiotics in meat


The present invention relates to the use of probiotics in meat for preserving the meat and for enhancing the consumer's health. A process for reducing proliferation of and/or for killing pathogenic bacteria in meat is disclosed, the process comprising the steps of: providing a raw meat, the raw meat being free of dry or fermented meat; and adding an effective amount of probiotics to the raw meat, the probiotics inducing no acidification or fermentation of the meat.
Nutri-qual Inc.


07/21/16
20160210581 

Method and emergency response notification


Embodiments of the invention leverage mobile proliferation to enable laypersons to initiate a timely and effective emergency response in case of an emergency, such as a medical emergency, e.g. Cardiac event.
Emergency University, Inc.


07/21/16
20160208250 

Therapeutic agent for corneal epithelial disorder


A therapeutic agent for a corneal epithelial disorder, containing a mir-203 inhibitor; an agent for promoting proliferation of corneal epithelial cells, containing a mir-203 inhibitor; a liquid culture medium for use in the manufacture of a corneal epithelial sheet, containing a mir-203 inhibitor; and a method for producing a corneal epithelial sheet, including the step of culturing corneal epithelial cells using a liquid culture medium containing a mir-203 inhibitor. According to the present invention, a therapeutic agent for a corneal epithelial disorder, an agent for promoting proliferation of corneal epithelial cells, a liquid culture medium for use in the manufacture of a corneal epithelial sheet, a method for producing a corneal epithelial sheet, including the step of culturing corneal epithelial cells using the liquid culture medium, and a method for treating a corneal epithelial disorder can be provided.
Senju Pharmaceutical Co., Ltd.


07/21/16
20160208248 

Neurocalcin delta inhibitors and therapeutic and non-therapeutic uses thereof


The present invention relates to an inhibitor of neurocalcin delta (ncald) for use in a method for the treatment or prevention of a patient suffering from a disorder associated with a pathological calcium homeostasis. Furthermore, the present invention refers to the use of such inhibitor of ncald for inducing axon proliferation in vitro and to a method for the differentiation and/or maturation of neuronal stem cells (nscs) in vitro and to the use of such inhibitor of ncald to restore impaired endocytosis being a consequence of disturbed ca2+ homeostasis in synaptic terminals essential for development, maturation and maintenance of synapses and neuromuscular junctions (nmjs)..
UniversitÄt Zu KÖln


07/21/16
20160207891 

Malignant and non-malignant disease treatment with ras antagonists


The present disclosure describes new inhibitors or antagonists of ras useful for the treatment of conditions resulting from ras-induced or mediated cellular processes, including cellular proliferation, differentiation, apoptosis, senescence, and survival. These cellular processes may be associated with a non-malignant or malignant disease, disorder, or pathological condition.
Pisces Therapeutics, Llc


07/21/16
20160206780 

Matrix scaffold for three-dimensional cell cultivation, methods of construction thereof and uses thereof


This invention provides a matrix scaffold for three-dimensional (3d) cell cultivation, a method of its construction, and its uses. The matrix scaffold results from a crosslinking reaction of a fibroin-like substance prepared by a specific method from silk cocoons or filaments, chitosan and crosslinking agents.
Suzhou Cancercell Biotechnology Co. Ltd


07/21/16
20160206644 

Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof


This application relates to combination therapies including triciribine compounds and epidermal growth factor receptor inhibitor compounds, particularly erlotinib-like compounds and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. .
University Of South Florida


07/21/16
20160206631 

Oxysterols that activate liver x receptor signaling and inhibit hedgehog signaling


This invention relates, e.g., to compositions comprising oxysterol compounds represented by formula i or formula ii, e.g., comprising one or more of oxy 16, oxy 22, oxy30, oxy 31, oxy35, oxy37, oxy43, oxy44, oxy45 or oxy47. The compounds are shown to be hedgehog pathway inhibiting, and to act as agonists for liver x receptor (lxr).
The Regents Of The University Of California


07/14/16
20160200783 

Use of multivalent synthetic ligands of surface nucleolin for treating cancer or inflammation


A method for treating disorders involving deregulation of cell proliferation and/or angiogenesis comprising the administration of an effective amount of a multivalent synthetic compound comprising a support on which at least 3 pseudopeptide units are grafted, said compound being of formula (i).. .
Centre National De La Recherche Scientifique (cnrs)


07/14/16
20160200740 

Compound for the treatment of human liver cancer and synthesizing it


The compound “2-((4-nitrophenyl)amino)-7,8,9,10-tetrahydro cyclohepta[4,5]thieno[2,3-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-11(6h)-one” and method of synthesizing it, wherein the compound is effective to inhibit the growth and proliferation of human liver cancer cells hepg2. The compound has a higher efficiency to inhibit the growth and proliferation of these cells as it has an inhibitory concentration value (ic50) of 0.7 μg, compared to reference medication doxorubicin that has an (ic50) value of 1.2 μg.

07/14/16
20160199630 

Methods and devices to prevent premature birth


Methods and devices to affect types, proportion, quantity, distribution, or proliferation of microorganisms within a female reproductive system.. .

07/14/16
20160199535 

Controlled and localized release of retinoids to improve neointimal hyperplasia


Controlled release vascular implants, such as vascular grafts, stents, wraps, and gels comprising a biocompatible polymer and all trans retinoic acid (atra), or its derivatives, can be used to treat, prevent, or inhibit thrombosis and/or neointimal hyperplasia which may otherwise be induced by prosthetic implantation. In particular, the implants herein can inhibit smooth muscle cell proliferation, neointimal hyperplasia, and upregulate antithrombotic genes and nitric oxide production in the vasculature.
Vesseltek Biomedical Llc


07/14/16
20160199383 

5-alkynyl-pyrimidines


R1 to r3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.. .

07/14/16
20160199346 

Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof


The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.. .
Orbital Atk, Inc.


07/07/16
20160198365 

Distributed load management on network devices


This disclosure relates to a system and method for dynamically managing load on network devices in a distributed manner. As the proliferation of data rich content and increasingly more capable mobile devices has continued, the amount of data communicated over mobile operator's networks has exponentially increased.
Cisco Technology, Inc.


07/07/16
20160194718 

Compositions and methods for identification, assessment, prevention, and treatment of cancer using histone h3k27me3 biomarkers and modulators


The present invention relates to methods for identifying, assessing, preventing, and treating cancer (e.g., lymphoid and/or myeloid malignancies such as b-all in humans). A variety of histone h3k27rne3 biomarkers are provided, wherein alterations in the copy number of one or more of the biomarkers and/or alterations in the amount, structure, and/or activity of one or more of the biomarkers is associated with cancer status and indicates amenability to treatment or prevention by modulating h3k27me3 levels.
Dana-farber Cancer Institute, Inc.


07/07/16
20160194611 

Simplified basic media for human pluripotent cell culture


Fully defined media that support pluripotent cell viability, proliferation, cloning, and derivation, as well as methods and compositions including these media are described. Methods for deriving ips cells from adult individuals under defined, xeno-free conditions are also described..
Wisconsin Alumni Research Foundation


07/07/16
20160194348 

Substituted pyrrolo[2,3-d]pyrimidines


This invention relates to compounds that inhibit e1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia..
Millennium Pharmaceuticals, Inc.


07/07/16
20160194311 

Substituted nicotinamide derivatives as kinase inhibitors


The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.. .
Allergan, Inc.


07/07/16
20160194286 

New anti-malarial agents


The present invention is related to a use of pyrazole derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to pyrazole derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation..
University Of Washington


07/07/16
20160193292 

Cell permeable inhibitors of the scaffold protein plenty of sh3 domains (posh) or sh3rfl


Plenty of sii3 (posh) and ink-interacting protein 1 (jip-1) function as a multi-protein scaffold network for tcr-mediated jnk1 activation in cd8+ t-cells. Disruption of the posh/jip-1 complex led to profound defects in the activation of jnk1, as well as deficient activation or induction of the transcription factors c-jun, t-bet and eomesodermin furthermore, disruption of the posh/jip complex in cd8+t-cells resulted in impaired proliferation, decreased cytokine expression and the inability to control tumors.
The Curators Of The University Of Missouri


07/07/16
20160193257 

Human-derived bacteria that induce proliferation or accumulation of regulatory t cells


Species of human-derived bacteria belonging to the clostridia class have been shown to induce accumulation of regulatory t cells (treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases..
School Corporation, Azabu Veterinary Medicine Educational Institution


07/07/16
20160193256 

Human-derived bacteria that induce proliferation or accumulation of regulatory t cells


Species of human-derived bacteria belonging to the clostridia class have been shown to induce accumulation of regulatory t cells (treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases..
School Corporation, Azabu Veterinary Medicine Educational Institution


07/07/16
20160193249 

Treatment of inflammatory diseases by carbon materials


In some embodiments, the present disclosure pertains to methods of treating an inflammatory disease in a subject by administering a carbon material to the subject. In some embodiments, the carbon material selectively targets t cells in the subject.
Baylor College Of Medicine


07/07/16
20160193180 

Composition for preventing and treating immune diseases containing daurinol compound as active ingredient


The daurinol compound according to the present invention exhibits excellent therapeutic effects on arthritis and inflammatory bowel diseases by having an excellent activity in inhibiting the generation of il-17 and tnf-α, which are inflammatory cytokines causing inflammation, and can alleviate transplant rejection by inhibiting the proliferation of alloreactive t cells and increasing regulatory t cells; therefore, the daurinol compound according to the present invention can be used as a pharmaceutical composition capable of treating and preventing immune diseases. In addition, being a natural substance derived from the mongolian medicinal plant haplophyllum dauricum or haplophyllum cappadocicum, the daurinol compound according to the present invention does not cause cytotoxicity and thus may be used as a composition for a functional health food capable of preventing and remedying immune diseases..
The Catholic University Of Korea Industry-academic Cooperation Foundation


06/30/16
20160191472 

System and sending and receiving secret message content over a network


The proliferation of personal computing devices in recent years, especially mobile personal computing devices, has led to increased concerns regarding the safety and security of documents and messages that are sent over networks. Users desire a system that provides for the setting of custom, content-agnostic, permissions at a message, document, and/or sub-document-level through communications networks.

06/30/16
20160188893 

System and applying adaptive privacy controls to lossy file types


The proliferation of personal computing devices in recent years, especially mobile personal computing devices, combined with a growth in the number of widely-used communications formats has led to increased concerns regarding the safety and security of documents and messages that are sent over networks. Users desire a system that provides for the setting of custom access permissions at a file-level or sub-file-level.

06/30/16
20160188887 

System and determining user-defined permissions through a network


The proliferation of personal computing devices in recent years, especially mobile personal computing devices, combined with a growth in the number of widely-used communications formats has led to increased concerns regarding the safety and security of documents and messages that are sent over networks. Users desire a system that provides for the setting of custom, content-agnostic, permissions at a message, document, and/or sub-document-level through a communications network.

06/30/16
20160186268 

Gene defects and mutant alk kinase in human solid tumors


Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of anaplastic lymphoma kinase (alk) kinase with part of a secondary protein have been identified herein in human solid tumors, e.g. Non-small cell lung carcinoma (nsclc).

06/30/16
20160186173 

C-myc antisense oligonucleotides and methods for using the same to treat cell-proliferative disorders


Provided herein are antisense oligonucleotides that can effectively prevent or decrease c-myc protein expression as well as decrease overall rates of cell proliferation in in vitro and mammalian in vivo models of cell proliferative disorders as well as methods for using the same.. .

06/30/16
20160186138 

Natural killer cells and methods for enhancing viability, proliferation and cytotoxicity of same following cryopreservation


The invention provides natural killer cells and improved methods for increasing natural killer cell viability, proliferation and cytotoxicity following cryopreservation.. .

06/30/16
20160185771 

Conjugate of benzofuranone and indole or azaindole, and preparation and uses thereof


The present invention relates to an oxo indirubin or isoindigo derivative, an oxo aza indirubin or isoindigo derivative, and their optical isomers, racemes, cis/trans isomers and pharmaceutically acceptable salts, which can be used for preparing a drug for treating or preventing diseases such as glucose metabolic disorder, inflammatory or autoimmune disease, neurodegenerative disease, a mental illness, tissue proliferation disease or tumors.. .

06/30/16
20160185742 

Method for preparing benzopyran compound and application thereof in treating pulmonary fibrosis


In which: r1 represents hydrogen, c1-c4 alkyl, or various remaining amino acid moieties after removal of an amino group; r2 represents hydrogen, c1-c4 alkyl, or various remaining amino acid moieties after removal of an amino group; r3 represents hydrogen, or c1-c4 alkyl; and n is any integer of 1-4, wherein the benzopyran compound is derived from a broth of streptomyces xiamenensis cgmcc no. 5675 by extraction, separation and purification.

06/30/16
20160185725 

C-met modulators and use


The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-met, kdf, c-kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

06/30/16
20160184333 

Mitochondria-targeted anti-tumor agents


Described are mitochondria-targeted anti-tumor agents, and methods of making and using the same for the treatment of disorders associated with unwanted cell proliferation.. .

06/30/16
20160183519 

Antibiotic treating a sapphire


The instant disclosure is related to a sapphire, including a surface and a silver-containing antibiotic source, wherein the silver-containing antibiotic source forms an antibiotic film covering the surface. The instant disclosure also relates to a sapphire, including a surface, an oxide layer extending from the surface to inside of the surface, and a silver-containing antibiotic source, wherein the silver-containing antibiotic source is distributed in the oxide layer, so as to turn the oxide layer into an antibiotic layer and turn the surface into an antibiotic surface.

06/23/16
20160178648 

Marker for detecting proliferation and treatment capacities of adipose-derived stem cell cultured in medium containing egf or bfgf, and use thereof


The present invention relates to: a composition for detecting a marker for detecting the proliferation capacity or treatment capacity of adipose-derived stem cells cultured in a medium containing epidermal growth factor (egf) or basic fibroblast growth factor (bfgf); and a detection method.. .

06/23/16
20160178278 

Food waste vacuum-drying disposal system


The present invention relates to a food waste vacuum-drying disposal system and, particularly, to a food waste vacuum-drying disposal system, which can be installed in a food waste collection vehicle due to the simple structure thereof and can carry out vacuum-dry disposal of food waste even while moving during food waste collection. The food waste vacuum-drying disposal system of the present invention is a device capable of: sterilizing and drying inputted food waste by heat converted from a light emitted from a heating element inside a vacuum tank; condensing and discharging, as condensed water, evaporated and sublimed gas generated during a drying process; and discharging, in the air, non-condensed gas such that food waste leachate can be disposed at the same time.

06/23/16
20160177261 

Methods of inducing and preventing neurofibromatosis in schwann cells


The invention provides a method of inducing neurofibromatosis type 2 (nf2) in schwann cells. The method comprises contacting the cells with laminin-1 so as to bind α6β1 integrin sufficiently to activate endogenous kinase cdc42-pak; and phosphorylating schwannomin-s518 in the cells by the activated kinase, effectively inactivating.

06/23/16
20160176937 

Short peptides derived from vdac1, compositions and methods of use thereof


The present invention relates to short peptides based on the amino acids sequence of the n-terminal domain of the human mitochondrial protein voltage-dependent anion channel 1 (vdac) and to peptide conjugates having a cell permeability enhancing moiety. The peptides, peptide conjugates and pharmaceutical compositions containing them are useful for treating diseases characterized by cell hyperproliferation or resistance to cell death and in particular, cancer..

06/23/16
20160176876 

2-substituted imidazo[4,5-d]phenanthroline derivatives and their use in the treatment of cancer


The present invention provides 2-substituted imidazo[4,5-d]phenanthroline compounds, which are capable of inhibiting proliferation of one or more renal cancer cells, pancreatic cancer cells, prostate cancer cells, colon cancer cells, leukemia cells, brain cancer/tumour cells or non-small cell lung cancer cells.. .

06/23/16
20160176825 

Kinase inhibitors for the treatment of disease


The invention relates to compounds and their use in the treatment of disease. Novel irreversible inhibitors of wild-type and mutant forms of egfr, fgfr, alk, ros, jak, btk, blk, itk, tec, and/or txk and their use for the treatment of cell proliferation disorders are described..

06/23/16
20160176731 

Apparatus for the purification of unclean water, in particular of wastewater and/or polluted water


The invention regards an apparatus (1) for the purification of unclean water (a), in particular of wastewater and/or polluted water (a), comprising:—at least one container (2), preferably cylindrical, delimiting a reaction chamber (3) arranged to receive a predetermined amount of water (a) to be treated; at least one support (11), preferably at least one free body (11a) not constrained to the apparatus (1), operatively arranged inside the reaction chamber (3) of the container (2) and provided with at least one surface for the formation and/or the proliferation of bacterial colonies in form of films capable of purifying unclean water (a), the support (11) periodically emerging, at least partially, from the water (a) to be treated in order to place the bacterial colonies into contact with the air. The container (2) is movable, in particular rotationally about a predetermined rotation axis (x), for periodically driving the support (11) between an immersed condition, wherein it is totally covered with water (a) to be treated, and an emerged condition, wherein it emerges, at least partially, from the water (a) to be treated..

06/23/16
20160175395 

Use of osteoprotegerin (opg) to increase human pancreatic beta cell survival and proliferation


It is disclosed herein that osteoprotegerin increases human beta cell proliferation and survival. Methods are provided for increasing beta cell proliferation, but contacting a beta cell with an effective amount of osteoprotegrin, a functional fragment, variant or fusion protein thereof.

06/23/16
20160175351 

Cancer treatment


Described herein are methods of inhibiting the proliferation of cancer cells and methods of treating cancer, as well as methods of predicting responsiveness of subjects to certain cancer treatments and methods of identifying subjects as candidates for certain cancer treatments.. .

06/23/16
20160175341 

Hydroxyalkyl starch for the treatment of hematological neoplasms


The present invention relates to hydroxyalkyl starch or a pharmaceutical preparation thereof for the treatment of a hematological neoplasm, especially by effectively reducing proliferation rate of cancer cells and inhibiting cancer cell growth and wherein the hydroxyalkyl starch has a mean molecular weight (mw) above 20 and below 1300 kda and a molar substitution (ms) in the range of from 0.1 to 1.5, wherein the alkylation may be an ethylation, propylation or butylation or mixes thereof; and wherein the alkyl may be further substituted.. .

06/23/16
20160175288 

Macrocyclic lactone compounds and methods for their use


The present invention provides a device for intracorporeal use including an implant or a temporary device and at least one source of a compound myolimus, or a derivative thereof. The present invention also provides a method of inhibiting cell proliferation by local administration of a therapeutically effective amount of a compound myolimus, or a derivative thereof.

06/23/16
20160175278 

Aryl hydrocarbon receptor (ahr) modifiers as novel cancer therapeutics


Provided herein are novel agents that modulate ahr activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis. The agents comprise ahr inhibitors or non-constitutive ahr agonists of formula (i) and (ii) for the inhibition of cancer cell growth and parameters that characterize tumor metastasis, such as tumor cell invasiveness..

06/16/16
20160169863 

Means and methods for assessing increased peroxisomal proliferation


The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation.
Basf Se




Proliferation topics: Proliferation, Cell Proliferation, Differentiation, Cancer Cell, Antibodies, Progesterone, Specificity, Cancer Cells, Antimicrobial, Lymphocyte, Cell Differentiation, Homogeneous, Amino Acids, Wound Healing, Epithelial

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