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Proliferation

Proliferation-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Proteins increasing pancreatic beta cell number and methods of use
University Of Oregon
October 12, 2017 - N°20170292115

Disclosed herein are bacterial proteins that increase pancreatic beta (β) cell number and/or proliferation, methods of increasing β cell number and/or proliferation using such proteins, and methods of treating or inhibiting diabetes in a subject by administering such proteins to the subject. In some embodiments, the protein has at least 80% sequence identity to the amino acid ...
Cancer cell growth inhibitor, anticancer agent, and method for screening same, as well as novel ...
Microbial Chemistry Research Foundation
October 12, 2017 - N°20170291879

A cancer cell proliferation inhibitor including at least one selected from compounds represented by structural formulae (1) to (8), wherein the cancer cell is at least one of a cancer cell overexpressing a wild-type epidermal growth factor receptor and a cancer cell expressing an epidermal growth factor receptor mutant viii.
Quinazolines and azaquinazolines as dual inhibitors of ras/raf/mek/erk and pi3k/akt/...
Asana Biosciences, Llc
October 12, 2017 - N°20170290838

The present application provides novel quinazolines and azaquinazolines and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in for co-regulating ras/raf/mek/erk and pi3k/akt/pten/mtor pathways by administering a therapeutically effective amount of one or more of the compounds of formula (i), wherein x, y, t and ...
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Proliferation Patent Applications
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Methods for improving proliferation and stemness of limbal stem cells
Ca, Inc.
October 05, 2017 - N°20170283773

When human limbal explants are cultured according to the methods, the wnt/β-catenin signaling is inhibited, resulting in improvement of lsc proliferation, and improvement in the sternness of lscs, and thus the lscs may be obtained in high yield. These effects may lead to a higher success rate of transplantation of a limbal explant outgrowth sheet into a ...
Use of inhibitors of binding between a par-1 receptor and its ligands for the treatment ...
University Of Rochester
October 05, 2017 - N°20170281710

The present invention relates to a method of treating glioma in a subject. The method comprises selecting a subject having a glioma, providing an inhibitor of binding between a par-1 receptor and a ligand of the par-1 receptor, and administering the inhibitor to the selected subject under conditions effective to treat the glioma and/or prevent spread of tumor cells. ...
Bone marrow stromal cell derived extracellular matrix protein extract and uses thereof
Stembiosys, Inc.
October 05, 2017 - N°20170281686

Disclosed are bone marrow stromal cell derived extracellular matrix protein extracts that are useful for the expansion and proliferation of mesenchymal stem cells and for various therapeutic applications.
Proliferation Patent Pack
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Proliferation Patent Applications
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For professional research & prior art discovery
inventor
  • 113+ full patent PDF documents of Proliferation-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Method for processing of physicochemical data in order to determine legionella in water samples from ...
University Of South Florida
September 28, 2017 - N°20170277866

This invention relates to a method to determine proliferation risk of legionella sp. And total aerobes, and to quantify their populations in all types of plants entailing potential proliferation and/or dissemination of these bacteria; firstly it performs previous calculations with previously measured source data in order to identify fundamental parameters for calculations. Secondly, data are sent from the user ...
Anti-cancer compositions containing wnt decoy receptor
Genemedicine Co., Ltd.
September 28, 2017 - N°20170275340

The present invention relates to a composition for preventing or treating cancer comprising wnt decoy receptor. The composition of the present invention or the expression product thereof inhibits cancer generation, growth, proliferation and metastasis, and induces apoptosis of cancer cells, by binding to wnt ligand and blocking ligand-receptor interactions, therefore may be effectively used as an anti-cancer agent.
Novel conjugates of cc-1065 analogs and bifunctional linkers
Syntarga Bv
September 28, 2017 - N°20170274090

This invention relates to novel analogs of the dna-alkylating agent cc-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver ...
Therapeutic and research application of pdcl3
Trustees Of Boston University
September 28, 2017 - N°20170274075

Described herein are novel compositions comprising, for example, pdcl3 polypeptides having vegfr-2 inhibitory activity, inhibitory pdcl3 antibodies and pdcl3-binding fragments thereof, or pdcl3 inhibitory nucleic acid molecules, and methods of their use in anti-angiogenesis and anti-tumor proliferation and invasiveness therapies, such as the treatment of cancer, as well as the treatment of those vascular diseases where pathological angiogenesis plays ...
Pharmaceutical compositions and methods
Tyme, Inc.
September 28, 2017 - N°20170274051

Pharmaceutical compositions and kits including a tyrosine hydroxylase inhibitor; melanin, a melanin promoter, or a combination thereof a p450 3a4 promoter; and a leucine aminopeptidase inhibitor are provided. Also provided are methods of treating cancer in a subject, comprising administering an effective amount of a tyrosine hydroxylase inhibitor, a melanin promoter, a p450 3a4 promoter, and a leucine aminopeptidase inhibitor ...
Polymer coatings containing moringa oil and neem oil and methods of making and using same
Magellan Companies, Inc.
September 28, 2017 - N°20170273313

This disclosure relates to compositions comprising a vehicle such as a polymer base, moringa oil and neem oil. The combination of the two oils is in an amount sufficient to prevent the establishment or proliferation of a microorganism, such as a mildew, on the surface of an inanimate object. The moringa oil and neem oil combination can be advantageously admixed ...
Targeting breast cancer therapy based on stromal subtypes and cd146 composition
The Regents Of The University Of Colorado, A Body Corporate
September 21, 2017 - N°20170269088

Methods for targeted breast cancer therapy in a subject based upon evaluating the stromal subtypes and cd146 composition in the adjacent tissue. Er+ breast cancers contain two caf subtypes defined by cd146 expression. Cd146neg cafs suppress er expression in er+ breast cancer cells, decrease tumor cell sensitivity to estrogen, switch er proliferation dependency toward egfr dependency and decrease tumor ...
Proliferation Patent Pack
Download 113+ patent application PDFs
Proliferation Patent Applications
Download 113+ Proliferation-related PDFs
For professional research & prior art discovery
inventor
  • 113+ full patent PDF documents of Proliferation-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
Samumed, Llc
September 21, 2017 - N°20170267697

Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e. G., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by ...
Anticancer nano-silver composition for treatment and prevention of cervical cancer, and preparation method and use ...
Changsha Digu Nano Biotechnology Co., Ltd.
September 21, 2017 - N°20170266229

The present invention provided an anticancer nano-silver composition for the treatment and prevention of cervical cancer. The composition contains nano-silver powder 3-200 mg/kg, carbomer 700-1000 mg/kg, triethanolamine 700-1000 mg/kg, glucose 2. 8-3. 2 g/kg, and water as remaining; of the nano-silver powder, wherein the purity of silver is ≧99. 99% and particle size is 1-5 nm. Experiments demonstrated that ...
Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity
University Of Maryland, Baltimore
September 21, 2017 - N°20170266181

Nonsteroid and steroid compounds that cause down-regulation of the androgen receptor (ar), both full length and splice variant, induce apoptosis and inhibit proliferation of inhibiting proliferation and migration of androgen sensitive cancer cells. The steroid compounds and nonsteroid compounds may be agents for the prevention and/or treatment of cancer, including prostate cancer, castration resistant prostate cancer, bladder cancer, pancreatic ...
Valve
Mcalpine & Co. Ltd.
September 14, 2017 - N°20170260725

The present invention provides an in-line valve particularly suitable for draining facilities to avoid odour penetrating habitable spaces or backflush of drainage liquids. The in-line valve comprises a body, preferably made of two engageable parts, an inset and a duckbill valve. The insert is located within the valve body and surrounding the duckbill valve. The insert funnels liquid from the ...
Method for the ex vivo cultivation of oral mucosal epithelial progenitor cells and oral mucosal ...
Chang Gung Memorial Hospital, Linkou
September 14, 2017 - N°20170260505

A method for the ex vivo cultivation of oral mucosal epithelial progenitor cells and oral mucosal epithelial cells includes: subjecting an oral mucosal tissue to an enzymatic digestion treatment with collagenase, so as to obtain cell aggregates which include oral mucosal epithelial progenitor cells and oral mucosal epithelial cells; cultivating the cell aggregates with an amniotic membrane in a serum-free ...
Substrates and inhibitors of prolyl oligopeptidase and methods of use thereof
The Board Of Regents Of The University Of Oklahoma
September 14, 2017 - N°20170260231

Inhibitors of fibroblast activation protein alpha (fap) and prolyl oligopeptidase (pop) are disclosed, along with their use in various therapies related to conditions, diseases, and disorders involving abnormal cell proliferation such as malignancies and angiogenesis, and in neural disorders such as alzheimer's disease. Stalk portions of the inhibitor molecules, and substrates of fap and pop, are also disclosed and may ...
Compunds for enzyme inhibition
Onyx Therapeutics, Inc.
September 14, 2017 - N°20170260230

Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of n-terminal nucleophile (ntn) hydrolases associated with the proteasome. The peptide-based compounds include an epoxide or aziridine, and functionalization at the n-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation. Oral administration of these peptide-based proteasome inhibitors is ...
3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
Samumed, Llc
September 14, 2017 - N°20170260209

Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e. G., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by ...
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