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Flow promoting ocular implant device and methods
|| List of recent Proliferation-related patents
|Method and apparatus for emergency response notification|
Embodiments of the invention leverage mobile proliferation to enable laypersons to initiate a timely and effective emergency response in case of an emergency, such as a medical emergency, e.g. Cardiac event.
|Flow promoting ocular implant device and methods|
Disclosed are devices and methods for treatment of eye disease such as glaucoma. Implants are described herein that create a flow field, such as between the anterior chamber and either the supraciliary space or suprachoroidal space.
The present application provides novel pyridine compounds and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds.
|Method for inducing hepatocyte proliferation and uses thereof|
The present application provides methods and compositions for inducing hepatocyte proliferation and liver regeneration, the latter being mainly dependent on hepatocyte proliferation even if all the other cell types divide to reconstitute the organ specific-lobular-architecture. The methods and compositions provided herein make use of an a3ar agonist.
The invention relates to a cell-penetrating peptide, optionally linked to a pro-apoptotic peptide, useful as pro-apoptotic agents, for inhibition of in vitro cell proliferation and for treatment of tumors.. .
|Deubiquitinase inhibitors and methods for use of the same|
Disclosed herein are methods of inhibiting a deubiquitinase (dub), methods of treating pathogenic infections (e.g., viral, bacterial, and/or parasitic), methods of inhibiting cell proliferation, methods of treating a neurodegenerative disease, methods of treating one or more symptoms of a neurodegenerative disease or a genetic disorder, and compounds.. .
|Aminoheteroaryl compounds and preparation method and use thereof|
The present invention refers to aminoheteroaryl compounds of the following formula (i) as well as the preparation method and use thereof, wherein r1 and r3 are defined in the description in details. The aminoheteroaryl compounds of the present invention are inhibitors of hepatocyte growth factor receptor (c-met), have favorable inhibitory effect against c-met and inhibitory effect against the proliferation of cancer cells, such that they may be used as therapeutic agents for the treatment of tumors and related diseases..
|Methods for treating cancers using oral formulations of cytidine analogs|
Provided herein are methods for treating subjects having a cancer, such as a relapsed or refractory solid tumor, wherein the method comprises administering to the subject a cytidine analog. In certain of the methods, the cytidine analog is administered alone or in combination with one or more anti-cancer agents.
|Methods and compositions for somatic cell proliferation and viability|
Methods and compositions for somatic cell proliferation as well as increasing viability of somatic cells are provided. The compositions include heparin binding protein isolated from a medium conditioned by growth of pluripotent stem cells, such as, human embryonic stem cells, human embryonic carcinoma cells.
|Potential regenerative cell and its culturing method|
The present invention relates to a type of cell—potential regenerative cell (prc) capable of continuous proliferation, and generated mammal (including human) cells, tissues and tissue-organs by in vitro culture and replication of prcs. The present invention also relates to the methods and cell growth regulators for culturing mammal (including human) prcs, tissues, and tissue-organs..
|Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation|
Methods are described for using compositions containing platelet-rich plasma for the treatment of a variety of tissue lesions, and the use of compositions containing platelet-rich plasma to accelerate or complete the differentiation of a cell line. Particularly, use of platelet-rich plasma in conjunction with cell differentiation..
|Adoptive transfer of cd8+ t cell clones derived from central memory cells|
The present invention provides a method of carrying out adoptive immunotherapy in a primate subject in need thereof by administering the subject a cytotoxic t lymphocytes (ctl) preparation in a treatment-effective amount. The method comprises administering as the ctl preparation a preparation consisting essentially of an in vitro expanded primate ctl population, the ctl population enriched prior to expansion for central memory t lymphocytes, and depleted prior to expansion of effector memory t lymphocytes.
|Methods for improved wound closure employing olivamine and endothelial cells|
The present disclosure relates to compositions for and methods of improving wound healing, including compositions for and methods of treating chronic wounds, and compositions for the inhibition and treatment of necrosis and extended quiescence that result in cellular necrosis instead of normal proliferation. The methods for wound healing administer one or more compositions including hydroxytyrosol and oleuropein with cells derived from umbilical cord blood..
|Nail stem cells and methods of use thereof|
The present invention is directed to an in vitro method for promoting proliferation, survival, and/or differentiation of k14+, k17+ nail stem cells (nscs). The instant methods may be used to generate an expanded population of k14+, k17+ nscs in vitro and expanded nsc populations in which a wnt pathway is activated are envisioned as therapeutic agents.
|Methods and materials for making cerium nanoparticles|
Disclosed herein are methods and materials for influencing proliferation of stem cells. Specifically exemplified herein are compositions comprising cerium oxide nanoparticles which can be used to stimulate proliferation of stem cells under common culture conditions, or which can be utilized to improve therapeutic outcomes..
|Method and apparatus for using pressure cycling and cold liquid co2 for releasing natural gas from coal and shale formations|
A method and apparatus for sequestering carbon dioxide (co2) gas and releasing natural gas from underground coal and/or gas shale formations using co2 gas captured from the flue gas of a coal burning power plant, and processing it to produce cold liquid pressurized co2, and injecting the cold liquid co2 under pressure to create fractures within the formation and causing the co2 to be adsorbed into the coal or gas shale and natural gas (ch4) to be desorbed, released and recovered. A special pressure cycling process is used to enable the pressure within the formation to be increased and decreased, including allowing the liquid co2 to change phase to a gaseous co2, and injecting the liquid co2 under pressure repeatedly, which causes greater expansion of the proliferation zone within the formation, and more efficiently releases ch4..
|Methods for modulating osteochondral development using bioelectrical stimulation|
Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications.
|Double-stranded nucleic acid molecule, cancer cell proliferation inhibitor and pharmaceutical agent suitable for prevention or treatment of cancer|
A double-stranded nucleic acid molecule including (a) a sense strand which includes a nucleotide sequence corresponding to a target sequence indicated by any one of seq id nos.: 1 to 21, and (b) an antisense strand which includes a nucleotide sequence complementary to that of the sense strand specified in (a), wherein the double-stranded nucleic acid molecule is for suppressing the expression of at least one of app and ebag9 genes.. .
|Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases|
The present methods and compositions are of use for treatment of conditions involving fibrosis, such as peyronie's disease plaque, penile corporal fibrosis, penile veno-occlusive dysfunction, dupuytren's disease nodules, vaginal fibrosis, clitoral fibrosis, female sexual arousal disorder, abnormal wound healing, keloid formation, general fibrosis of the kidney, bladder, prostate, skin, liver, lung, heart, intestines or any other localized or generalized fibrotic condition, vascular fibrosis, arterial intima hyperplasia, atherosclerosis, arteriosclerosis, restenosis, cardiac hypertrophy, hypertension or any condition characterized by excessive fibroblast or smooth muscle cell proliferation or deposition of collagen and extracellular matrix in the blood vessels and/or heart. In certain embodiments, the compositions may comprise a pde-4 inhibitor, a pde-5 inhibitor, a compound that elevates cgmp and/or pkg, a stimulator of guanylyl cyclase and/or pkg, a combination of a compound that elevates cgmp, pkg or no with an antioxidant that decreases ros, or a compound that increases mmp activity..
|Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis|
The present disclosure provides innovative methodology and related compositions and kits for preventing and treating various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using an inhibitor of processed forms of lysyl oxidase or lysyl oxidase-like proteins, an inhibitor of lox and an inhibitor of a loxl, or a synergistic combination of an inhibitor of lox or loxl combined with other therapeutic agents. Also provided are innovative methods for selecting agents that prevent or inhibit tumor invasion, angiogenesis and metastasis, by contacting cells that are in an epithelial-mesenchymal transition (emt) state with a candidate agent and detecting a change in the emt state of the cells.
|Strain of exopolysaccharide-secreting lactobacillus brevis and application thereof|
A strain of exopolysaccharide-secreting lactobacillus brevis, bdlb0001, and an application thereof. The lactobacillus brevis is deposited at the china general microbiological culture collection center of the china committee of culture collection for microorganisms, with a deposit number of cgmcc no.
|Method for inhibiting proliferation of plant pathogenic microbe using collimonas bacterium|
To provide a method for inhibiting the proliferation of a plant pathogenic bacterium. A method for inhibiting the proliferation of a plant pathogenic bacterium, including culturing a microorganism having an ability to inhibit the proliferation of a plant pathogenic bacterium and belonging to the genus collimonas, and seeding the cultured microorganism to a plant soil..
|Advanced methods and systems for treating cell proliferation disorders|
The present invention relates to methods for treating cell proliferation disorders comprising (1) administering to the subject at least one activatable pharmaceutical agent that is capable of activation by a simultaneous two photon absorption event and of effecting a predetermined cellular change when activated, (2) administering at least one plasmonics-active agent to the subject, and (3) applying an initiation energy from an initiation energy source to the subject, wherein the plasmonics-active agent enhances or modifies the applied initiation energy, such that the enhanced or modified initiation energy activates the activatable pharmaceutical agent by the simultaneous two photon absorption event in situ, thus causing the predetermined cellular change to occur, wherein said predetermined cellular change treats the cell proliferation related disorder, and the use of plasmonics enhanced photospectral therapy (pepst) and exiton-plasmon enhanced phototherapy (epep) in the treatment of various cell proliferation disorders, and the pepst and epep agents and probes. .
|Methods and related compositions for the treatment of cancer|
A method of treatment and/or prevention of cancer comprises administering agents which cause increased intracellular granularity in cancer cells, at least in an amount sufficient to inhibit proliferation of such cells and preferably in an amount sufficient to lead to cancer cell death. The method is particularly directed to refractory cancer, particularly hormone refractory prostate cancer.
|Pharmaceutical containing ppar-delta agonist|
A preparation containing [3-[2-[4-isopropyl-2-(4-trifluoromethyl)phenyl-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazol-6-yl]oxyacetic acid, [4-[3-[2-(4-trifluoromethyl)phenyl-4-isopropyl-5-thiazolyl]propionyl]-2-methylphenoxy]acetic acid or [4-[3-[2-(2-hydroxy-4-chlorophenyl)-5-isopropyl-4-oxazolyl]propionyl]-2-methylphenoxy]acetic acid, or a pharmacologically acceptable salt thereof as an active ingredient is used as an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, as well as a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like.. .
|Certain chemical entities, compositions, and methods|
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described. Specifically quinoxaline derivatives of formula i and their use in modulating the activity of braf and/or mutant braf kinase to regulate and modulate abnormal or inappropriate cell proliferation, differentiation, or metabolism are disclosed.
|Benzene, pyridine, and pyridazine derivatives|
Wherein r1, r2, r3, r4, r5, r6, r7, n, q1, q2, q3, y, and x1-x4 are as defined herein. Compounds of formula i are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like.
|Compounds for proteasome enzyme inhibition|
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of n-terminal nucleophile (ntn) hydrolases. The activities of those ntn having multiple activities can be differentially inhibited by the compounds described.
|Use of foti to enhance stem cell mobilization and proliferation|
The present invention provides a method of using polygonum multiflorum or extracts thereof to enhance stem cell mobilization in a subject, including hematopoietic stem cells (hscs) and bone marrow stem cells (bm-scs). In one embodiment, a blended composition of plant parts, fruits, mushrooms, microorganisms, maternal fluids, and extracts thereof are used to promote mobilization of stem cells, resulting in migration of the stem cells to specific sties of maintenance and repair within tissues and/or organs.
|Method to induce neovascular formation and tissue regeneration|
The present invention relates, e.g., to a method for inducing arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or for inducing mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte, comprising administering to a cell or tissue in need thereof a dose of a polynucleotide that encodes a vascular endothelial growth factor (vegf), or that encodes a polypeptide comprising an active site of the vegf. The coding sequence is operably linked to an expression control sequence; and the dose is sufficient to induce arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or to induce mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte.
|Human-derived bacteria that induce proliferation or accumulation of regulatory t cells|
Species of human-derived bacteria belonging to the clostridia class have been shown to induce accumulation of regulatory t cells (treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases..
|Regenerative tissue matrix|
A process for the preparation of a tissue matrix suitable for regenerative repair of tissues, including contacting an isolated connective tissue with an amount of detergent and an amount of disinfectant to significantly reduce at least one of lipids, phospholipids, nucleic acids, major histocompatibility (mhc) antigens, contaminating microorganisms, and endotoxins. The process further provides for less significant reduction in proteoglycan content while retaining the overall structure of the tissue matrix produced.
|Methods and systems for treating cell proliferation related disorders|
And a kit for performing the method, a computer implemented system for performing the method, a pharmaceutical composition useful in the method and a method for causing an autovaccine effect in a subject using the method.. .
|Apparatus for preventing algae proliferation|
Disclosed is an apparatus for preventing algae proliferation including floats that float on the water; a frame-shaped underwater supporting structure that is provided with connecting wires so as to be disposed in water while being connected to one sides of the floats; an underwater film that is attached to the underwater supporting structure to be spread in a horizontal direction so as to reduce the amount of sunlight introduced in water under the underwater supporting structure, and that is provided with a circulating hole formed in one side to penetrate in a vertical direction to have permeability of water; and a float circulating unit that is provided with an impeller disposed in the circulating hole, and that selectively rotates the impeller in a clockwise direction or counterclockwise direction to allow underwater floats positioned above and under the underwater film to be circulated through the circulating hole.. .
|Methods for treating leishmaniasis|
Methods are provided to inhibit proliferation of leishmania parasites, and in particular leshmania donovani with imido-substituted 1,4-naphthoquinones, including novel compounds. Administering an imido-substituted 1,4-naphthoquinone can used to provide prophylaxis or treatment to a patient in need of treatment against leishmaniasis disease..
|Aurora kinase modulators and method of use|
Wherein a1-8, d′, l1, l2, r1, r6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases.
|Treatment of ebv and khsv infection and associated abnormal cellular proliferation|
A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with epstein-barr virus (ebv), is provided that includes administering an effective amount of a 5-substituted uracil nucleoside or its pharmaceutically acceptable salt or prodrug, optionally in a pharmaceutically acceptable diluent or excipient.. .
|Novel use of rhododendrin|
The present invention relates to a novel use of rhododendrin, and more particularly to a composition for antioxidant purposes or for the prevention or treatment of hyperproliferative skin disorders, which comprises rhododendrin as an active ingredient; and a method for inhibiting reactive oxygen species or for preventing and treating a hyperproliferative skin disorder, which comprises administering an effective amount of rhododendrin to a subject in need thereof. Rhododendrin is not cytotoxic and has an excellent effect of eliminating a large amount of reactive oxygen species (ros) generated by tnf-α/ifn-γ or uv light, and thus is effectively used to prepare an antioxidant cosmetic composition or an antioxidant food composition.
|Lactobacillus plantarum inducia dsm 21379 as enhancer of cellular immunity, hypocholesterolemic and anti-oxidative agent and antimicrobial agent against clostridium difficile|
A microorganism strain lactobacillus plantarum inducia dsm 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L.
|Small molecule inhibitors of stat3 with anti-tumor activity|
The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of stat3 signaling, stat3 dimerization, stat3-dna binding, stat5-dna binding, and/or aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The compounds of the invention include, but are not limited to, nsc 74859 (s31-201), nsc 42067, nsc 59263, nsc 75912, nsc 11421, nsc 91529, nsc 263435, and pharmaceutically acceptable salts and analogs of the foregoing.
|Small molecule anti-fibrotic compounds and uses thereof|
And pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis or dysproliferation.. .
|Methods of modulating cell proliferation and cyst formation in polycystic kidney and liver diseases|
The present invention provides a method for preferentially reducing the proliferation of cystic epithelial cells in the kidney or bile duct in a mammal in need thereof by administering a 20-hete synthesizing enzyme inhibitor or a 20-hete antagonist to the mammal in an amount sufficient to preferentially reduce the proliferation of cystic epithelial cells over normal epithelial cells such as tubule epithelial cells in the kidney or bile duct. The present invention also provides a method for preventing or treating autosomal dominant polycystic kidney disease (adpkd), autosomal recessive polycystic kidney disease (arpkd), arpkd associated congenital hepatic fibrosis, arpkd associated caroli's disease, or cholangiocarcinoma in a mammal in need thereof by administering a 20-hete synthesizing enzyme inhibitor or a 20-hete antagonist to the mammal in an amount sufficient to prevent or treat the disease..
|Anti-ceacam1 recombinant antibodies for cancer therapy|
Provided herein are recombinant monoclonal antibodies and antigen-binding portions thereof useful in inhibiting ceacam1 in tumor cells, and methods of their use in anti-tumor proliferation and invasiveness therapies, such as the treatment of cancer, particularly pancreatic cancer.. .
|Use of therapeutic compositions comprising hyaluronan and therapeutic antibodies|
The present invention relates generally to treatment and prophylactic protocols for cellular disease or disorders, such as diseases and disorders associated with abnormal cellular proliferation. More particularly, the present invention provides uses of compositions comprising therapeutic antibodies and hyaluronan in the treatment or prophylaxis of cellular diseases and disorders..
|Method for treating or preventing graft versus host disease|
A method of treating or preventing graft versus host disease (gvhd) in a subject receiving a graft comprising hematopoietic cells is provided. The method comprises contacting the graft ex vivo with an amount of a myxoma virus effective to inhibit proliferation of t lymphocytes in the graft and to treat or prevent gvhd in the host subject following infusion of the graft into the subject.
|Method for the biological control of listeria|
The invention relates to a method for controlling the proliferation of listeria, with the exception of the treatment methods applied to the human or animal body, characterized in that it uses protozoa of the willaertia magna species, and also to a disinfecting agent containing such protozoa.. .
|Tyrosine isomers as therapeutic agents|
The present invention relates to prevention or treatment of diseases related to abnormal cell proliferation, such as cancer, by administering meta- or ortho-tyrosine to a subject in need thereof, for instance a human subject. More specifically, the present invention provides isomers of tyrosine for its use in the prevention or treatment of a disease and in the preparation of pharmaceutical compositions, methods of treating or preventing diseases, such as cancer and cancer metastases, and pharmaceutical compositions containing meta- and/or ortho-tyrosine..
|Use of strigolactones and strigolactone analogs for treating proliferative conditions|
Compound of formula x wherein p1 is a fused-ring system comprising one 6-membered and two 5-membered rings; v indicates an s or r configuration; or individual isomers or pharmaceutically acceptable salts thereof, or mixtures thereof, in the preparation of an active agent for preventing or inhibiting cell proliferation or for inducing cell death.. .
|Compositions and methods for increasing proliferation of adult salivary stem cells|
The present disclosure provides methods of increasing proliferation of adult salivary stem cells. The methods include contacting adult salivary stem cells in vivo, in vitro, or ex vivo with an aldehyde dehydrogenase (aldh) agonist.
|Combination compositions and methods of treatment|
The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as methods of modulating cellular proliferation processes, and methods of treating disease, disorders, and symptoms thereof.. .
|Use of opioid antagonists to attenuate endothelial cell proliferation and migration|
The invention provides methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that associated with angiogenesis, using opioid antagonists, including, but not limited to, those that are peripherally restricted antagonists.. .
|Use of a rock inhibitor to sustain primary human keratinocytes in a proliferative state|
Disclosed herein is the finding that treatment with a rock inhibitor increases proliferation and induces immortalization of primary keratinocytes. Accordingly, provided is a method of immortalizing primary keratinocytes by exposure to a rock inhibitor.
|Method of reducing and improving the appearance of scar tissue|
Scars, stretch marks, keloids, keratosis, and other skin lesions can be ameliorated through topical application of a composition containing a fortified botanical complex inhibiting tryptase and chymase. A flavonoid with antioxidant properties valuable in inflammatory stress; blocking the release of histamine, inhibiting leukocytic elastase and strengthening the protective properties surrounding the extracellular matrix.
|Strain of exopolysaccharide-secreting lactobacillus plantarum and application thereof|
Provided is a strain of exopolysaccharide-secreting lactobacillus plantarum and an application thereof. The deposit number of the strain is cgmcc no.
|Cell proliferation inhibitors and conjugates thereof|
The invention further provides pharmaceutical compositions comprising these compounds and immunoconjugates, and compositions comprising the immunoconjugates or compounds with a therapeutic co-agent, and methods to use these compounds, conjugates and compositions for treating cell proliferation disorders.. .
|Process for biologically combating pseudomonas|
The invention relates to a method for controlling the proliferation of pseudomonas, with the exception of the treatment methods applied to the human or animal body, characterized in that it uses protozoa of the willaertia magna species, and also to a disinfecting agent containing such protozoa.. .
|Materials and methods useful to induce cell death via methuosis|
The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer.
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Proliferation topics: Proliferation, Cell Proliferation, Differentiation, Cancer Cell, Antibodies, Progesterone, Specificity, Cancer Cells, Antimicrobial, Lymphocyte, Cell Differentiation, Homogeneous, Amino Acids, Wound Healing, Epithelial
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