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Proliferation patents



      
           
This page is updated frequently with new Proliferation-related patent applications. Subscribe to the Proliferation RSS feed to automatically get the update: related Proliferation RSS feeds. RSS updates for this page: Proliferation RSS RSS


Three dimensional matrix for cancer stem cells

University Of South Carolina

Three dimensional matrix for cancer stem cells

Three dimensional matrix for cancer stem cells

Oakland University

System and method to facilitate the growth of stem cells

Date/App# patent app List of recent Proliferation-related patents
06/25/15
20150177248
 Use of sirt7 as novel cancer therapy target and  treating cancer using the same patent thumbnailUse of sirt7 as novel cancer therapy target and treating cancer using the same
The present invention relates to the use of sirt7 (sirtuin 7) as a marker for diagnosis of liver cancer. More specifically, the invention relates to a liver cancer diagnostic marker comprising sirt7 gene, a liver cancer diagnostic composition, kit and microarray comprising the same, and a method of diagnosing liver cancer using the same.
Catholic University Industry Academic
06/25/15
20150176026
 Replication competent pseudo-type retrovirus vector system patent thumbnailReplication competent pseudo-type retrovirus vector system
The present invention provides a vector system in which a mulv-gag gene, a mulv-pol gene, and a galv-env gene are expressed in two separate vectors. The vector system is capable of inserting a therapeutic gene to these two separate vectors, and in this raged, the size of an inserted gene is not limited and a variety of foreign therapeutic genes may be inserted to the vectors.
Inje University Industry-academic Cooperation Foundation
06/25/15
20150175972
 Three dimensional matrix for cancer stem cells patent thumbnailThree dimensional matrix for cancer stem cells
Synthetic inert 3d gel culture systems are described that can be finely tuned to exhibit desired and predetermined physical, chemical, mechanical, and biochemical properties. The culture system can be utilized to study the effect of microenvironmental factors on cancer cell response, and in particular on cancer stem cell (csc) response.
University Of South Carolina
06/25/15
20150175961
 System and method to facilitate the growth of stem cells patent thumbnailSystem and method to facilitate the growth of stem cells
A method and system to maintain adult or embryonic stem cells employing 3-d culture conditions is disclosed. Hydrogel scaffolds, composed of hydrophilic polymer networks are provided to emulate a fully hydrated native extracellular matrix and natural soft tissue.
Oakland University
06/25/15
20150174202
 Methods and compositions for modulating beta cell proliferation patent thumbnailMethods and compositions for modulating beta cell proliferation
Methods and compositions are provided for modulating pancreatic islet β cell proliferation. Aspects of the methods include promoting β cell proliferation by providing agents that promote pdgfr signaling, or inhibiting β cell proliferation by providing agents that inhibit pdgfr signaling.
The Board Of Trustees Of The Leland Stanford Junior University
06/25/15
20150174149
 Compositions including triciribine and methods of use thereof patent thumbnailCompositions including triciribine and methods of use thereof
This invention encompasses combination therapies including tcn, tcn-p, tcn-pm and/or related compounds and one or more additional anti-cancer agents, for example, taxanes a molecule that modulates the her2/neu (erbb2) receptor, anthracyclin compounds, epidermal growth factor receptor inhibitor compounds, one or more platinum compounds and bortezomib and derivatives thereof and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. .
University Of South Florida
06/25/15
20150174126
 Pharmaceutical combination patent thumbnailPharmaceutical combination
The present invention relates to a pharmaceutical combination which may be useful for the treatment of diseases which involve cell proliferation, which involve migration or apoptosis of myeloma cells, which involve angiogenesis or which involve fibrosis. The invention also relates to a method for the treatment of said diseases, comprising simultaneous, separate or sequential administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations..
Boehringer Ingelheim International Gmbh
06/18/15
20150166521
 Substituted dialkyl(oxido)-lambda4-sulfanylidene nicotinamide  derivatives as kinase inhibitors patent thumbnailSubstituted dialkyl(oxido)-lambda4-sulfanylidene nicotinamide derivatives as kinase inhibitors
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.. .
Allergan, Inc.
06/18/15
20150166518
 Substituted nicotinamide  derivatives as kinase inhibitors patent thumbnailSubstituted nicotinamide derivatives as kinase inhibitors
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.. .
Allergan, Inc.
06/18/15
20150166509
 Smoothened modulators and methods of use thereof patent thumbnailSmoothened modulators and methods of use thereof
Compounds of general formulas (i), (ia), (ib) are described, along with compositions containing the same and methods of use thereof, inhibiting the hedgehog pathway in a cell or inhibiting unwanted proliferation of a cell.. .
Duke University
06/18/15
20150165095

Compositions useful as antibiofilm or antimicrobial agents and methods using same


The present invention includes compositions and methods useful for removing microorganisms and/or biofilm-embedded microorganisms from the surface of a medical device or subject's body. The present invention further includes compositions and methods useful for coating medical devices.
Baylor College Of Medicine
06/18/15
20150164987

Wnt signaling inhibitor comprising insulin-like growth factor-binding protein


Provided is a novel soluble factor that modulates morphogenesis and cell proliferation, such as cardiac development and/or cardiomyocyte differentiation. Specifically provided are: an inhibitor of wnt signalling, comprising an insulin-like growth-factor-binding protein (igfbp), the protein being binding to a wnt receptor, and/or a polynucleotide encoding the protein; a medicament for prevention and/or treatment of a disease due to enhanced wnt signalling, comprising the inhibitor of wnt signalling, and a medicament for induction of cardiomyocyte differentiation; and a method for prevention and/or treatment of a disease due to enhanced wnt signalling and a method of inducing cardiomyocyte differentiation, the methods each comprising using the inhibitor of wnt signalling, and a cardiomyocyte, which is obtained by the method of inducing cardiomyocyte differentiation, and a use thereof..
National University Corporation Chiba University
06/18/15
20150164973

Chondrocyte proliferation promoting agent


The present invention provides a novel active ingredient which can be safely used in preventing, ameliorating or treating diseases related to the cartilage such as cartilage damages and cartilage disorders. Since the egg yolk protein hydrolyzate has an effect on chondrocyte proliferation promotion, it is useful as an active ingredient for preventing, ameliorating or treating cartilage disorders and for preventing, ameliorating or treating joint pain.
Pharma Foods International Co., Ltd.
06/18/15
20150164944

Treatment for chitin-containing microorganisms


The present disclosure relates to treatment of chitin-containing microorganism infection or colonization on an aquatic animal. The methods, systems, and kits provided herein facilitate termination and/or inhibition of proliferation of chitin-containing microorganisms (e.g., saprolegnia and sea lice)..
Benchmark Animal Health Limited
06/11/15
20150159142

Novel low-molecular-compound for improving production, maintenance and proliferation of pluripotent stem cells, composition comprising the same, and culture method


According to the present invention, when the novel low-molecular-weight compound rsc-133 is added in a culture process for producing reprogrammed pluripotent stem cells from human differentiated cells, it can increase the efficiency of reprogramming and can significantly reduce the time required for the induction of reprogramming. Particularly, the novel compound rsc-133 can substitute for c-myc acting as both a reprogramming factor and an oncogenic factor, and it can effectively increase the efficiency of reprogramming in both normal oxygen culture conditions and hypoxic culture conditions.
Korea Reasearch Institute Of Bioscience And Biotechnology
06/11/15
20150159140

Method for preparing endocrine aggregate of insulin-producing beta cells from human pluripotent stem cells


The present invention prepared insulin-producing endocrine cells by inducing the differentiation of human embryonic stem cells or human induced pluripotent stem cells into definitive endoderm (de), pancreatic endoderm (pe), endocrine progenitors (ep), and endocrine cells (ec) stepwise in that order. Particularly, the present invention established the conditions for the formation of an insulin producing endocrine aggregate (ea) from the endocrine cells.
Korea Advanced Institute Of Science And Technology
06/11/15
20150159137

Adjuvant for rapid proliferation of human mesenchymal stem cells in vitro, rapid proliferation of human mesenchymal stem cells in vitro, growth factor harvested from rapid proliferation of human mesenchymal stem cells in vitro and use thereof


An adjuvant for rapid proliferation of human mesenchymal stem cells in vitro is provided to overcome the problem of low cell amplification efficiency of human mesenchymal stem cells in a culture process. The adjuvant added for the culture of human mesenchymal stem cells includes at least one antioxidant, and a basic fibroblast growth factor (fgf-2).
Buddhist Tzu Chi Medical Foundation
06/11/15
20150159131

Methods and compositions for regulating musashi function


The invention generally features compositions and methods for detecting and regulating cell proliferation, potentiation, and differentiation in a population of cells. In particular, compositions and methods are provided for modulating the activity of musashi proteins.
Board Of Trustees Of The University Of Arkansas
06/11/15
20150158938

Gremlin-1 antibody


The present invention relates to a gremlin-1 antibody that inhibits gremlin-1 in a manner independent of bone morphogenetic protein (bmp) or vascular endothelial growth factor receptor-2 (vegfr-2), thus providing the effect of treating cancer. The antibody of the present invention inhibits cell migration, cell invasion and cell proliferation which are dependent on gremlin-1, and therefore, can be effectively used in treating cancer or immune disease..
Snu R&db Foundation
06/11/15
20150158919

Novel bioactive protein isolated from chinese yam and uses thereof


A protein isolated from the chinese yam dioscorea opposita that stimulates estrogen and progesterone release in vitro and in vivo but does not stimulate the proliferation of breast and ovarian cancer cells is disclosed. The protein exhibits anti-osteoporotic activity in vivo.
The University Of Hong Kong
06/11/15
20150158853

Cytochrome p450 inhibitors and uses thereof


And pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis and proliferation, and where anti-fibrotic or anti-proliferative activity is beneficial.. .
06/11/15
20150157738

Papillomavirus pseudoviruses for detection and therapy of tumors


Disclosed herein are methods of detecting tumors, monitoring cancer therapy, and selectively inhibiting the proliferation and/or killing of cancer cells utilizing a papilloma pseudovirus or a papilloma virus-like particle (vlp). .
The Usa, As Represented By The Secretary, Dept. Of Health And Human Services
06/11/15
20150157607

Compounds that enhance atoh1 expression


This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an atoh1 gene (e.g., hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation..
The Brigham & Women's Hospital, Inc.
06/11/15
20150157584

Inhibitors of hippo-yap signaling pathway


This invention provides methods of preventing, reducing, delaying or inhibiting the proliferation, growth, migration and/or metastasis of cancer by administering an effective amount of an inhibitor of the hippo-yap signaling pathway.. .
The Regents Of The University Of California
06/04/15
20150153324

Non-invasive measuring proliferation and differentiation state of cells by using magnetic resonance spectroscopy, and cell proliferation and differentiation marker for magnetic resonance spectroscopy used therefor


Provided are a noninvasive measurement of cell signals and a method thereof, wherein the measurement method can ascertain cell proliferation and differentiation states using mrs and can enable cells to be reused so that cell states can be evaluated with improved reproducibility and reliability. And since the cell signals are noninvasively measured using the mrs, the corresponding cells can be reused so that the cost and time needed for one experiment can be remarkably reduced..
Inje University Industry-academic Cooperation Foundation
06/04/15
20150152422

Mirnas as therapeutic targets in cancer


Micrornas (mirnas) are a class of non-coding small rna molecules that regulate gene expression at the post-transcriptional level by interacting with 3′ untranslated regions (utrs) of their target mrnas. The invention relates to the application of mir-192 and mir-215.
The Research Foundation For The State University Of New York
06/04/15
20150152138

Uses of kappa opioid synthetic peptide amides


The invention relates to methods of use of synthetic peptide amides that are ligands of the kappa opioid receptor in the treatment and prevention of kappa opioid receptor-associated diseases and conditions; and particularly to uses of these agonists in the prophylaxis, inhibition and treatment of pain, inflammation and pruritis associated with a variety of diseases, disorders and conditions. Inflammatory conditions preventable or treatable by the methods of the invention include diseases and conditions associated with elevated levels of a proinflammatory cytokines, such as tnf-α, il-1β, il-6, mmp-1 and mmp-3.
Cara Therapeutics, Inc.
06/04/15
20150152105

Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof


Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the wnt pathway and/or of one or more of wnt signaling components.
Samumed, Llc
06/04/15
20150152104

7-azaindole derivatives


Compounds of the formula (i) in which r, r1, r2 and r3 have the meanings indicated in claim 1, are inhibitors of pdk1 and cell proliferation/cell vitality and can be employed for the treatment of tumours.. .
Merck Patent Gmbh
06/04/15
20150152093

3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh


Or a pharmaceutically acceptable salt thereof, wherein r1, r2a, r2b and r3-r7 are herein. The invention is also directed to compositions containing a compound of formula (i) and to the use of such compounds in the inhibition of mutant idh proteins having a neomorphic activity.
06/04/15
20150152049

Materials and methods useful to induce vacuolization, cell death, or a combination thereof


The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer.
The University Of Toledo
06/04/15
20150151002

Targeted therapy for the prevention of restenosis in the cardiovascular system


Provided herein are compositions and methods for targeted drug delivery to prevent restenosis in the cardiovascular system. In particular, provided herein are nanoscale delivery vehicles for drugs that prevent proliferation and neointimal hyperplasia..
Northwestern University
06/04/15
20150150989

Plasticizers for coating compositions


A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive agent.
Abbott Cardiovascular Systems Inc.
06/04/15
20150150940

Trefoil family factor proteins and uses thereof


The invention provides for methods for treating an inflammatory disease of the digestive system in a subject by administering a trefoil family molecule. The invention provides for methods for treating a digestive system cancer in a subject by administering a trefoil family molecule.
The Trustees Of Columbia University In The City Of New York
06/04/15
20150150862

1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof


Provided herein are compounds according to formulas (i) or (ii) and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancer, abnormal cellular proliferation, angiogenesis, alzheimer's disease, lung disease, osteoarthritis, idiopathic pulmonary fibrosis and neurological conditions/disorders/diseases.. .
Samumed, Llc
06/04/15
20150150785

Cosmetic compositions comprising magnetosomes and uses thereof


The present invention relates to cosmetic and skin care compositions comprising magnetosomes. The invention also relates to methods for the treatment of diseases associated with increased proliferation or accumulation of differentiating keratinocytes..
Natura Bisse International S.a.
06/04/15
20150150251

Biosolubilizer


Composition containing at least one substance that is not water-soluble and is solubilised in a sophorolipid, and at least water, and use thereof for cleaning hard surfaces and laundry, for killing plants, for combating insect pests, for combating fungus and mould proliferation, for combating gastropods, for combating moss, algae and lichen proliferation, for the cosmetics industry and for skin and hair care.. .
Soliance
05/28/15
20150148401

Methods and compositions for inhibiting the growth and/or proliferation of myc-driven tumor cells


The invention generally relates to methods for identifying and using anticancer therapeutic agents and, more particularly, to methods for identifying and using inhibitors of genes for inhibiting the growth and/or proliferation of myc-driven tumor cells relative to normal cells.. .
Fred Huchinson Cancer Research Center
05/28/15
20150148383

Methods for inhibiting or reversing epiretinal membrane formation


Described herein are treatment methods involving the administration of nicotinamide, which has been discovered to stabilize the normal phenotype of retinal pigment epithelial cells and to prevent retinal pigment epithelial cell proliferation. Diseases and disorders that can be treated according to the methods disclosed herein include, e.g., macular pucker, proliferative vitreoretinopathy, preretinal fibrosis, vitreomacular traction, tractional retinal detachment, and phthsis bulbi, cystoid macular edema (cme) arising from intraocular inflammation due to uveitis, vasculitis, trauma, surgery, and collagen vascular disease (e.g., behcets disease or sarcoidosis), and age related macular degeneration..
Regenerative Research Foundation
05/28/15
20150148356

Compounds for dry skin and anti-ageing application


The present invention relates to the cosmetic use, as agent for preventing and/or treating an aesthetic defect in the skin and/or its appendages that is associated with an imbalance in the differentiation and/or proliferation of the cells of an epidermis, of an effective amount of at least one compound represented by one of the general formulae, (ia) or (ib). .
L'oreal
05/28/15
20150147807

High-throughput image-based chemical screening in zebrafish blastomere cell culture


Disclosed are methods of inducing differentiation of stem into myogenic cells without gene manipulation and for inducing proliferation of satellite cells. The cells can be used as a source of cells for transplantation in a subject in need thereof.
Children's Medical Center Corporation
05/28/15
20150147417

Method and pharmaceutical composition for liver fibrosis prevention and/or treatment


The present invention is related to a method for liver fibrosis prevention and/or treatment and a pharmaceutical composition thereof. The method and the pharmaceutical composition are made by taking the advantage of blumea lacera ‘efficacy in accumulating lipid in hepatic stellate cells, down-regulating the proliferation of hepatic stellate cells, inhibiting the mobility of hepatic stellate cells, preventing the activation of hepatic stellate cells, and decreasing the synthesis of ecm proteins.
National Dong Hua University
05/21/15
20150143562

Non-human animals having a humanized a proliferation-inducing ligand gene


Non-human animals, cells, methods and compositions for making and using the same are provided, wherein the non-human animals and cells comprise a humanized a proliferation-inducing ligand gene. Non-human animals and cells that express a human or humanized a proliferation-inducing ligand protein from an endogenous a proliferation-inducing ligand locus are described..
Regeneron Pharmaceuticals, Inc.
05/21/15
20150143559

Non-human animals having a humanized a proliferation-inducing ligand gene


Non-human animals, cells, methods and compositions for making and using the same are provided, wherein the non-human animals and cells comprise a humanized a proliferation-inducing ligand gene. Non-human animals and cells that express a human or humanized a proliferation-inducing ligand protein from an endogenous a proliferation-inducing ligand locus are described..
Regeneron Pharmaceuticals, Inc.
05/21/15
20150143557

Composition for inducing proliferation or accumulation of regulatory t cells


It was found that bacteria belonging to the genus clostridium induce accumulation of regulatory t cells (treg cells) in the colon. Moreover, the present inventors found that regulatory t cells (treg cells) induced by from these bacteria suppressed proliferation of effector t-cells.
The University Of Tokyo
05/21/15
20150143539

Method and system for backing up and restoring license


A method for backing up and restoring a license is provided, which solves the problem of right proliferation in the prior art caused when an original license is transmitted to a user when a server restores the license. The method includes: backing up, at a server, license information of a first device, and associating the license information with a user identifier, the license information reflecting the current state information of a license when the first device reports the license information the last time; requesting, by a second device, the server to restore the license; and validating, by the server, a user identifier of the second device and the user identifier associated with the license information, and upon determination that the two user identifiers are consistent, generating a license based on the license information backed up, and transmitting the license to the second device.
Huawei Technologies Co., Ltd.
05/21/15
20150141735

Method and device for the desctruction of cells with uncontrolled proliferation


The present invention relates to a method and device for the selective destruction of cells that with uncontrolled proliferation in an animal organism, with minimum damage to the surrounding tissue thereby and without needing to perform any kind of surgical operation on the patient: the method consists of the detection of the tumorous area (1) and the sequential and alternate application of at least two alternating magnetic fields with different directions to the treatment area or application until achieving the heating and destruction of the cells. The device used is, therefore, comprised of at least two electromagnets (11, 12) or at least two pairs of electromagnets (11-11′, 12-12′) all being located around the perimeter of a hypothetical circumference or sphere, with the electromagnets in opposing pairs where each opposing pair generates an electromagnetic field in one direction and orientation..
Investigaciones, Desarrollos Innovaciones Tat Iberica, S.l.
05/21/15
20150141660

Substrates and inhibitors of antiplasmin cleaving enzyme and fibroblast activation protein and methods of use


The presently disclosed and claimed inventive concepts include inhibitors of antiplasmin cleaving enzyme (apce) and fibroblast activation protein alpha (fap) which can be used in various therapies related to disorders of fibrin and α2-antiplasmin and abnormal cell proliferation. The presently disclosed and claimed inventive concepts also include substrates of apce and fap, which may be used, for example, in screening methods for identifying such inhibitors.
The Board Of Regents Of The University Of Oklahoma
05/21/15
20150141523

Compounds for use in the treatment of autoimmune inflammatory disease


And salts thereof is useful in the prophylaxis or treatment of inflammatory bowel disease or other inflammatory autoimmune diseases with similar aetiology involving t-cell proliferation or or function.. .
05/21/15
20150141463

Substituted pyrazolone compounds and methods of use


The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans..
Sunshine Lake Pharma Co., Ltd.
05/21/15
20150141430

Method for modulating canonical wnt pathway using folate and inositol


The canonical wnt signaling pathway is implicated in wound healing. Administration of a composition having myo-inositol and folic acid upregulates fibronectin and provides the greatest protection in an additive/synergistic manner against adverse wnt/β-catenin-mediated effects on cell processes relating to cell differentiation, proliferation, and migration that relate to wound healing..
University Of South Florida
05/21/15
20150141364

Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof


This application relates to combination therapies including triciribine compounds and epidermal growth factor receptor inhibitor compounds, particularly erlotinib-like compounds and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. .
University Of South Florida
05/21/15
20150141346

Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof


This application relates to combination therapies including triciribine and related compounds and bortezomib and derivatives thereof analogs and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. .
University Of South Florida


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Proliferation topics: Proliferation, Cell Proliferation, Differentiation, Cancer Cell, Antibodies, Progesterone, Specificity, Cancer Cells, Antimicrobial, Lymphocyte, Cell Differentiation, Homogeneous, Amino Acids, Wound Healing, Epithelial

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