This page is updated frequently with new Proliferation-related patent applications.
| Virtual server agent load balancing|
Virtual machine (vm) proliferation may be reduced through the use of virtual server agents (vsas) assigned to a group of vm hosts that may determine the availability of a vm to perform a task. Tasks may be assigned to existing vms instead of creating a new vm to perform the task.
Commvault Systems, Inc.
| Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein|
A novel family of human mitochondrial rnas, referred to as chimeric rnas, which are differentially expressed in normal, pre-cancer and cancer cells, are described. Oligonucleotides targeted to the chimeric rnas are provided.
Andes Biotechnologies S.a.
| Method for producing single cell oil from lignocellulosic materials|
The present disclosure relates to methods for producing microbial lipids. The present disclosure also relates to methods for producing microbial lipids using inhibitors obtainable from lignocellulosic materials to supress the proliferation of unwanted microorganisms in the fermentation broth.
| Materials and methods for treatment of pulmonary arterial hypertension|
The invention relates to the use of microrna 96 and precursors and mimics thereof for the inhibition of vascular cell proliferation and/or vascular remodelling, and for the treatment of associated medical conditions such as pulmonary arterial hypertension (pah).. .
The University Court Of The University Of Glasgow
| Anti-egfrviii antibodies and uses thereof|
The present invention provides antibodies that bind to the class iii variant of egfr (egfrviii) and methods of using the same. According to certain embodiments, the antibodies of the invention bind human egfrviii with high affinity.
Regeneron Pharmaceuticals, Inc.
| Peptide based inhibition of capcna interaction in cancer|
Peptides derived from cancer specific isoform of proliferating cell nuclear antigen (capcna, also known as cspcna) or from nmpcna-interacting proteins interfere with intracellular protein-protein interaction, thereby causing a reduction in the proliferative potential of cancer. These peptides serve as therapeutic compositions to reduce the proliferation of cancer cells and also augment existing chemotherapeutic methods..
| Indazole-3-carboxamides and their use as wnt/beta-catenin signaling pathway inhibitors|
Indazole-3-carboxamide compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole-3-carboxamide compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis and osteoarthritis), the modulation of cellular events mediated by wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the wnt pathway and/or of one or more of wnt signaling components.
| Antibiotic sensitivity-restoring and photosensitive agents|
The present disclosure describes a method to treat conditions, including bacterial infections and cancer, using a photosensitive compound that, upon exposure to white light, can be activated. The photosensitive compound can also interact synergistically with antibiotics used concomitantly to kill drug-resistant bacteria.
New Mexico Tech Research Foundation
| Composition and kits for pseudoplastic microgel matrices|
This invention relates generally to water-insoluble but water-swellable and deformable crosslinked pegylated microgel particles of proteins and protein-based macromolecules that are pseudoplastic (shear thinning) and flow in aqueous media under shear and which can be injected or made to flow, wherein said microgel particles can reform as a duster of microgel particles when shearing forces are removed. The microgel particles function as a matrix to support cell growth, viability, and proliferation..
Rochal Industries, Llc
| Polypeptide, nucleotide sequence thereof, and using the same for preventing dna synthesis and inhibiting cell proliferation|
A polypeptide represented by seq id no: 1 and a method for treatment of a tumor and another disease associated with abnormal cell proliferation are described. The method includes administering a pharmaceutically-effective amount of the polypeptide to a patient in need thereof..
Wuhan Yicheng Biotech. Inc.
Small molecules that promote skin regeneration
Provided herein are small molecules for the induction of fibroblast proliferation and increased secretion or production of proteins. The small molecules described herein can be used for the promotion of skin regeneration.
International Stem Cell Corporation
Compositions and methods for inhibiting tumor growth
The present invention relates to compositions and methods for preventing and treating cell proliferation in cancer. More specifically, the present invention relates to compositions and methods for inhibiting tumor growth, and for treating proliferative diseases, particularly colon and breast cancer, with a combined pharmacological approach.
Method, apparatus, and computer-readable medium for generating a data proliferation graph
An apparatus, computer-readable medium, and computer-implemented method for generating a data proliferation graph, including receiving a selection of a target data store, identifying a plurality of data stores which have either received data that was previously on the target data store or which have sent data that was subsequently on the target data store, the plurality of data stores being divided into a plurality of proliferation levels corresponding to degrees of separation from the target data store and direction of data propagation relative to the target data store, generating a data proliferation graph, and transmitting at least one portion of the data proliferation graph.. .
Assays and methods for cell proliferation-targeted treatment therapies
Assays are described which measure polyamine transport activity and markers associated with polyamine transport and metabolism. These data are then used for the selection of treatments using therapies which target polyamine transport and polyamine metabolism.
University Of Central Florida Research Foundation, Inc.
Methods for the detection and treatment of leukemias that are responsive to dot1l inhibition
Disclosed are: (i) methods for identifying leukemia patients who (or leukemia cells that) do not exhibit an mll-translocation, rearrangement or mll-partial tandem duplication but who are nonetheless susceptible to treatment with dot1l inhibitors; and (ii) methods for treating leukemia patients who (or inhibiting proliferation or inducing apoptosis of leukemia cells that) do not exhibit an mll-translocation, rearrangement or mll-partial tandem duplication with dot1l inhibitors. The patients identified as susceptible and the patients (or cells) treated exhibit elevated expression of a hox cluster gene or of a hox cluster-associated gene.
Memorial Sloan-kettering Cancer Center
Crystalline forms of ponatinib hydrochloride
The present disclosure relates to polymorphic forms of the hydrochloride salt of ponatinib (“compound 1”) and to processes for the preparation of these polymorphic forms. The present disclosure also generally relates to a pharmaceutical composition comprising the forms, as well of methods of using the form(s) in the treatment of disorders associated with pathological cellular proliferation, such as neoplasms, and cancer..
Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the wnt pathway and/or of one or more of wnt signaling components.
Control of hypoxia-inducible gene expression with oligooxopiperazine nonpeptidic helix mimetics
The present invention relates to oligooxopiperazines that mimic helix αb of the c-terminal transactivation domain of hif-1α. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of hif-1α with creb-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation)..
University Of Southern California
Polysubstituted pyrroles having microtubule-disrupting, cytotoxic and antitumor activities and methods of use thereof
The present invention provides polysubstituted pyrrole compounds, pharmaceutically effective salts, prodrugs, solvates and hydrates thereof, having antimitotic, antiproliferative and cytotoxic activity, activity against cells expressing the drug efflux protein, p-glycoprotein, or cells expressing the β-iii isotype of tubulin and antitumor activity. Also provided are methods of utilizing these compounds for inhibiting the proliferation of cancer cells as well as their medical use, in particular for treating cancer, including drug resistant cancer..
The Board Of Regents Of The University Of Texas Sy Stem
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Novel active ingredient in cicatrization and use thereof
The present invention relates to the use of a known compound as an agent for promoting and/or accelerating fibroblast proliferation and/or differentiation and, consequently, cicatrization. This compound is a copolymer of a 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulphonic acid salt and of propenoic acid 2-hydroxyethyl ester.
Lactobacillus plantarum inducia dsm 21379 as enhancer of cellular immunity, hypocholesterolemic and anti-oxidative agent and antimicrobial agent against clostridium difficile
A microorganism strain lactobacillus plantarum inducia dsm 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L.
Tervisliku Pllma Biotehnoloogiate Arenduskeskus OÜ (bio-competence Centre Of
Method and system for creating and distributing solar energy system design, sales and marketing data
The present invention solves a complex real problem that is a major obstacles for solar energy mass proliferation. Installation site survey is a very cost intensive business process for roof-top and ground mount solar energy systems it keeps the solar energy system cost relatively higher, this cost category is termed as ‘soft-cost’ in the industry.
Method for promoting hair growth using composition comprising pdgf-d treated adipose-derived stem cells
Provided is a composition for promoting hair growth comprising platelet-derived growth factor-d (pdgf-d)-treated adipose-derived stem cells (ascs) as an active ingredient, and more particularly, a therapeutic agent for hair loss comprising ascs with increased proliferation and migration by pdgf-d and increased expression and secretion of a growth factor as an active ingredient. Pdgf-d-treated ascs have improved hair regenerative potential through the increases in proliferation, migration and growth factor secretion and thus are useful for a therapeutic agent for hair loss or a cosmetic for preventing hair loss..
Industry-academic Cooperation Foundation, Yonsei University
Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
Provided herein are placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof. Also provided herein are compositions comprising the same, and methods of using placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof, to suppress the growth or proliferation of tumor cells, cancer cells, and the like, and to treat individuals having tumor cells..
Activity enhancing curcumin compositions and methods of use
The present invention provides for compositions or formulations including a curcuminoid and at least one of resveratrol, resveratrol derivative, catechin, or catechin derivative. The present invention also provides for a method of treating any disease where uncontrolled cellular proliferation occurs, such as cancers.
The Feinstein Institute For Medical Research
Agents and methods for inhibiting human pluripotent stem cell growth
The present invention relates to compositions and methods for inhibiting or suppressing undifferentiated or pluripotent stem cell growth and proliferation in a differentiated or differentiating cell population or culture.. .
Anti-wt1/hla bi-specific antibody
Disclosed herein is a bi-specific form of a t cell receptor mimic (tcrm) mab with reactivity to human immune effector cell antigen and a wt1 peptide/hla-a epitope. This antibody selectively bound to leukemias and solid tumor cells expressing wt1 and hla-a as well as activated resting human t cells to release interferon-(ifn-γ) and to kill the target cancer cells in vitro.
Eureka Therapeutics, Inc.
Compositions and methods for antibodies targeting epo
The present invention relates to compositions and methods for the inhibition of epo. The invention provides antibodies and antigen binding fragments thereof that bind to epo and are able to inhibit epo-dependent cell proliferation and/or epo-dependent cell signaling..
Compound for inhibiting the growth and proliferation of human liver cancer cells and synthesizing it
The compound “2-((4-nitrophenyl)amino)-6,7,8,9-tetrahydro-3h-cyclohepta[4,5]thieno-[2,3-d]pyrimidin-4(5h)-one” and method of synthesizing it, wherein the compound is effective to inhibit the growth and proliferation of human liver cancer cells hepg2. The compound has an inhibitory concentration value (ic50) of 0.7 μg, compared to reference medication doxorubicin that has an (ic50) value of 1.2 μg.
Inhibitors of bruton's tyrosine kinase
This application discloses compounds according to generic formula i: wherein all variables are defined as described herein, which inhibit btk. The compounds disclosed herein are useful to modulate the activity of btk and treat diseases associated with excessive btk activity.
Hoffmann-la Roche Inc.
Core-centered granule composed of micro-structure body
Granules useful for bone regenerative filler that exhibit enhanced cell migration and proliferation and differentiation.. .
The Trustees Of Columbia University In The City Of New York
Methods for inhibiting stenosis, obstruction, or calcification of a stented heart valve or bioprosthesis
The present invention relates to methods for inhibiting stenosis, obstruction, or calcification of a valve following implantation of a valve prosthesis which may involve disposing a coating composition which is a combination of two different drugs one to target inflammation and attachment of the target cell and the second drug to inhibit proliferation and calcification on an elastical stent, gortex graft or valve leaflet, the combination effect of the two drug therapies incorporated into the polymer to attach to the bioprosthesis will improve the efficacy of the inhibition of calcification and the improvement of the longevity of the prosthetic material including the stent, the valve, and the gortex covering. The valve prosthesis and or gortex graft is mounted on the elastical stent or prosthesis such that the elastical stent is in contact with the valve..
Composition for promoting differentiation or proliferation of erythrocytic cells, containing monoacetyl diacylglycerol compound as active ingredient
The present invention relates to compositions for promoting differentiation or proliferation of erythrocytic cells containing a monoacetyl diacylglycerol compound as an active ingredient, and pharmaceutical compositions and health functional food compositions for preventing, treating or alleviating erythrocytopenia containing the same. The monoacetyldiacylglycerol compound of the present invention is effective in promoting differentiation or proliferation of erythrocytic cells.
Korea Research Institute Of Bioscience And Biotech Nology
Screening assay for agents that influence beta cell number and/or phenotype
The present invention in general relates to a method for identifying compounds that influence beta cell number and/or phenotype, more in particular beta cell differentiation, proliferation and/or expansion. Said method comprising culturing beta cells or precursors thereof in 5 medium comprising glucose, and determining the ability of said compound to induce the glucocorticoid receptor dependent-transactivation pathway in said beta cells.
Compositions and methods of using transposons
The present invention provides compositions and methods of using transposons. In one aspect, methods are disclosed that are useful for identifying negatively selected genes in an insertional mutagenesis screen.
Method of producing fr901228
Depsipeptides and congeners thereof are disclosed having structure (i), wherein m, n, p, q, x, r1, r2 and r3 are as defined herein. These compounds, including fr901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant.
Astellas Pharma Inc.
Method of using a mir172 molecule for decreasing inflammation
An exemplary embodiment relates to a method of using a plant-derived mir172 molecule or its synthetic equivalent, selected from amongst mir172a or mir172b, for decreasing inflammatory processes in an organism, a method of decreasing b and t lymphocyte proliferation, as well as a method of reducing protein fan (factor associated with neutral sphingomyelinase activation) level. Exemplary embodiments provide a novel therapeutic method based on mirna molecules, which through the interaction with mrna encoding fan protein, negatively regulate its expression and decrease the inflammatory response of the organism..
Uniwersytet Im. Adama Mickiewicza W Poznaniu
Method of improving the yield of algae production
The present disclosure discloses a method of improving the yield of algae from an environment consisting of diatoms. This selective culturing of algae from a mixed environment is achieved by the use of a urea cycle pathway inhibitor.
Reliance Industries Limited
Inhibition of pulmonary fibrosis with nutlin-3a and peptides
In fibrotic lung fibroblasts, basal levels of p53 protein (and mir-34a) are markedly suppressed, leading to reduced p53-mediated inhibition of upa and upar, or concurrent induction of pai-1. These changes contribute to excessive fl-fibroblast proliferation and production of extracellular matrix (ecm), and, therefore, pulmonary fibrosis.
Board Of Regents, The University Of Texas System
Trail enhancers for the selective killing of cancer cells
The invention is directed to methods of inducing apoptosis, arresting cell cycle, or inhibiting cellular proliferation, or any combination thereof, in a tumor cell, by administration of an effective amount of an n-acyl homoserine lactone analog (ahl), optionally in conjunction with a tumor modulating agent such tumor necrosis factor (tnf) related apoptosis inducing ligand (trail) to the patient. Novel bioactive analogs of an n-acyl homoserine lactone are also provided..
The Scripps Research Institute
Containers designed to keep food fresher
Containers and bags are designed to keep food fresher by including a substance such as zeolite, which inhibits bacteria from spoiling food. This matter absorbs or adsorbs ethylene gas or other gases that age food.
Method for obtaining a spray-on cellular compound of human fibroblasts and keratinocytes in solution and the use thereof as a regenerative agent in skin lesions
The present invention relates to a process for obtaining a compound of cellular spraying for fibroblasts and human keratinocytes and its use as regenerative agent of cutaneous lesions, mainly in diabetic ulcers, first, second, and third grade burns, and a substitute for the use of flaps techniques. The process for obtaining a compound of cellular spraying for fibroblasts and human keratinocytes includes the steps of separating the dermis and epidermis layers, incubation of the epidermis layer, disintegration of dermis layer and proliferation of fibroblasts, disintegration of the epidermis layer, proliferation of keratinocytes in suspension, preparation of the cross-linking reaction agent solution of the cellular spraying solution, and preparation of cellular spraying solution.
The invention provides a skin disinfectant for treating skin with eczema, preventing bacterial proliferation, and removing biofilm. Compositions of the invention include hypochlorous acid, acetic acid, water, and one or more additives or excipients.
Wiab Water Innovation Ab
Therapeutic compounds that suppress protein arginine methyltransferase activity for reducing tumor cell proliferation
The described invention provides methods for modulating gene expression of a gene related to proliferation of a population of tumor cells. The method entails administering a therapeutic amount of a therapeutic compound to a cell, a tissue, or a mammal, wherein the therapeutic amount of the therapeutic compound is effective to suppress methyltransferase activity of a protein arginine methyltransferase.
Epinova Therapeutics Corp.
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Novel use of panduratin derivatives or extract of kaempferia pandurata comprising the same
The present invention relates to a new use of panduratin derivatives or a kaempferia pandurata extract comprising the same. More particularly, the present invention relates to a composition for improving wrinkles and/or preventing aging, which comprises a panduratin derivative or a kaempferia pandurata extract comprising the same.
Newtree Co., Ltd.
Novel selenium-containing compound
The invention provides a method of improving an antioxidant effect in a redox pathway that involves selenium in a subject, an in vitro method of inhibiting oxidation in a cell or tissue, and an in vitro method of promoting proliferation of a cell, by use of a selenium-containing compound of chemical formula 1:. .
Fisheries Research Agency
Antibodies directed against icos and uses thereof
The present invention provides antibodies directed against icos or a derivative thereof which neutralize icos engagement on treg by inhibiting the fixation between icos and icos-l and abrogate proliferation of treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against icos or a derivative thereof which induce il-10 and ifnγ production, induce cd4+ t cells proliferation, reduce tconv proliferation, and increase the immunosuppressive function of treg..
Centre Leon Berard
Pharmaceutical compositions and methods
Pharmaceutical compositions and kits including a tyrosine hydroxylase inhibitor; melanin, a melanin promoter, or a combination thereof; a p450 3a4 promoter; and a leucine aminopeptidase inhibitor are provided. Also provided are methods of treating cancer in a subject, comprising administering an effective amount of a tyrosine hydroxylase inhibitor, a melanin promoter, a p450 3a4 promoter, and a leucine aminopeptidase inhibitor to the subject in need thereof.
Use of mks inhibitor peptide-containing compositions for treating non-small cell lung cancer with same
The described invention provides pharmaceutical compositions, systems and methods for treating a non-small cell lung cancer (nsclc) solid tumor comprising a population of tumor cells. The method includes administering a pharmaceutical composition comprising a therapeutic amount of a polypeptide having the amino acid sequence yaraaarqarakalarqlgvaa (seq id no: 1) or functional equivalent thereof, and a pharmaceutically acceptable carrier, wherein therapeutic amount of the polypeptide is effective to inhibit a kinase activity in the population of tumor cells and to reduce cancer cell proliferation, to reduce tumor size, to reduce tumor burden, to induce tumor cell death, to overcome tumor chemoresistance, to enhance tumor chemosensitivity, or a combination thereof..
Moerae Matrix, Inc.
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Compositions and methods for altering human cutaneous microbiome to increase growth of staphylococcus epidermidis and reduce staphylococcus aureus proliferation
An antibacterial composition comprising arginine bicarbonate, zinc carbonate, preferably arginine bicarbonate and zinc carbonate (abzc), in combination, plus one or more physiologically acceptable excipients, administered for the modification of cutaneous microfloras, generally to inhibit the growth of pathogenic staphylococcus aureus bacteria by promoting the growth of non-pathogenic staphylococcus epidermidis bacteria.. .
The Research Foundation For The State University Of New York
Pharmaceutical compositions and methods
Pharmaceutical compositions and kits including a tyrosine hydroxylase inhibitor; melanin, a melanin promoter, or a combination thereof a p450 3a4 promoter; and a leucine aminopeptidase inhibitor are provided. Also provided are methods of treating cancer in a subject, comprising administering an effective amount of a tyrosine hydroxylase inhibitor, a melanin promoter, a p450 3a4 promoter, and a leucine aminopeptidase inhibitor to the subject in need thereof.
Crk - a novel target for cancer therapy
The invention features a method of identifying a therapeutically active compound that inhibits apoptotic compensatory signaling complex (acsc)-induced cell proliferation.. .
Rush University Medical Center
Methods for inducing cardiomyocyte proliferation
Methods for inducing cardiomyocyte proliferation, e.g., in vivo, by administering a composition comprising mirna17-92 cluster oligonucleotides, e.g., mir-19a oligonucleotides, mir-19b oligonucleotides, or both mir-19a and mir-19b oligonucleotides.. .
Children's Medical Center Corporation
Humanized and variant anti-vegf antibodies and various uses therefor are disclosed. The anti-vegf antibodies have strong binding affinities for vegf; inhibit vegf-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo..
The invention relates to a cell-penetrating peptide, optionally linked to a pro-apoptotic peptide, useful as pro-apoptotic agents, for inhibition of in vitro cell proliferation and for treatment of tumors.. .
Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof
The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.. .
University Of Maryland, Baltimore County
Novel compositions, uses and methods for making them
Generally, the present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same..
Heterocyclic compounds and methods for their use
The present invention relates to heterocyclic compounds useful for antagonising angiotensin ii type 2 (at2) receptor. More particularly the invention relates to piperazine and diazepine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with at2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration..
Modulation of splenocytes in cell therapy for traumatic brain injury
The invention provides methods for treating traumatic brain injury. The invention is generally directed to treating traumatic brain injury by administering cells that have one or more of the following effects in an injured subject: interact with splenocytes, preserve splenic mass, increase proliferation of cd4+ and cd8+ t-cells, increase il-4 and il-10, and increase m2:m1 macrophage ratio at the site of injury.
Abt Holding Company
Methods of treating keratin hyperproliferation disorders using mtor inhibitors
A method of treating or preventing keratin hyperproliferation skin disorders is set forth. The method includes the administration of an mtor inhibitor to a subject afflicted with the hyperproliferation disorder.
The present invention relates to a glucan having a weight average molar mass of 15,000 to 50,000 g/mol on a single chain basis and a weight average molar mass in aqueous solution on an aggregate basis of 4 to 20×105 g/mol and existing in gel form in aqueous solution at a concentration ≧1% at 25° c. And neutral ph and having a melting temperature (gel to sol) of 35 to 60° c.
Biotec Pharmacon Asa
Antimicrobial cosmetic container containing impregnating material
Provided is a cosmetic container containing an antimicrobial impregnating material made of a polycaprolactone polyol foam in an antimicrobial sealed container, and more particularly, an antimicrobial cosmetic container containing an antimicrobial material which may reinforce disadvantages of polyester polyol foam- and polyether polyol foam-type impregnating materials, such as water resistance (hydrolysis resistance) and oil resistance and inhibit the proliferation of microorganisms.. .
Dmt Co., Ltd.
Compositions and methods for treating cancer and modulating stress granule formation
The invention provides methods for treating or decreasing the likelihood of developing a stress-granule related disorder and/or cancer by administering one or more poly-adp-ribose polymerase (parp) inhibitors, one or more parp activators, one or more poly-adp-ribose glycosylase (parg) activators, and/or one or more poly-adp-ribose glycohydrolase arh3 activators. The invention also provides corresponding methods of decreasing stress granule formation and/or proliferation in a cell or a population of cells.
Massachusetts Institute Of Technology
Defined media for expansion and maintenance of pluripotent stem cells
The present invention provides methods to promote the proliferation of undifferentiated pluripotent stem cells in defined media. Specifically, the invention provides a defined cell culture formulation for the culture, maintenance, and expansion of pluripotent stem cells, wherein culturing stem cells in the defined cell culture formulation maintains the pluripotency and karyotypic stability of the cells for at least 10 passages.
Janssen Biotech, Inc.
Cell culture medium and bioprocess optimization
The invention provides a chemically defined cell culture media and methods of using the media. The invention also provides an inverse screen to identify small molecules and synergies stimulating proliferation in a chemically defined medium.
University Of Notre Dame Du Lac
Culture medium for establishing neuroepithelial stem cells, establishing neuroepithelial stem cells, and applications thereof
The present invention discloses a culture medium for establishing neuroepithelial stem cells, a method for establishing neuroepithelial stem cells, and the applications thereof, wherein the culture medium comprises differentiation culture medium for inducing and differentiating pluripotent stem cells to elementary neuroepithelial stem cells as well as proliferation culture medium for amplifying the elementary neuroepithelial stem cells; and the pluripotent stem cells can be differentiated to the elementary neuroepithelial stem cells in the differentiation culture medium. While the elementary neuroepithelial stem cells have the functions of the neuroepithelial stem cells, they cannot be stably amplified in long term culture under the conventional culture conditions, however they are maintained the stability properties in long term culture in the proliferation culture medium.
Yunnan Key Lab Of Primate Biomedicine Research
Anti-prlr antibodies and uses thereof
The present invention provides antibodies that bind to prolactin receptor (prlr) and methods of using the same. According to certain embodiments, the antibodies of the invention bind human prlr with high affinity.
Regeneron Pharmaceuticals, Inc.
Chromene derivatives as inhibitors of tcr-nck interaction
And which present the ability to inhibit the lymphocytes proliferation mediated by the tcr interaction with nck, so that the present invention also relates to the use of these compounds for the treatment of diseases or conditions wherein said interaction triggers a complication such as transplant rejection reactions, immune or autoimmune diseases, inflammatory diseases or proliferative diseases.. .
Regenerative prostheses as alternatives to donor corneas for transplantation
The present invention relates to a corneal implant comprising a matrix material and a core part wherein the core part is arranged essentially in the middle of the matrix material. The core part is anti fouling in order to stop cell proliferation across said part.
The present invention relates to a pharmaceutical combination which may be useful for the treatment of diseases which involve cell proliferation, which involve migration or apoptosis of myeloma cells, which involve angiogenesis or which involve fibrosis. The invention also relates to a method for the treatment of said diseases, comprising simultaneous, separate or sequential administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations..
Boehringer Ingelheim International Gmbh
Nanogel-mediated drug delivery
Provided herein are methods of inhibiting proliferation of one or more tumor cells comprising contacting the one or more tumor cells with a composition comprising one or more epigenetic drugs that inhibit one or more epigenetic mechanisms of the tumor cells, wherein the one or more epigenetic drugs are encapsulated in a nanogel. The invention is also directed to methods of treating a tumor, metastasis of a tumor or a combination thereof in an individual in need thereof.
The Cleveland Clinic Foundation
Methods of treatment with drug eluting stents with prolonged local elution profiles with high local concentrations and low systemic concentrations
A drug eluting stent can include a stent body having a polymeric coating with a lipophilic and/or hydrophilic element. A drug that has a bioactivity that inhibits cell proliferation can be disposed in the polymeric coating.
Method for biologically combating naegleria fowleri, and disinfecting agent containing protozoa of the species willaertia magna
The invention relates to a process for combating the proliferation of the naegleria genus and in particular of the species naegleria fowleri, with the exception of the treatment methods applied to the human or animal body, characterized in that it uses protozoa of the species willaertia magna, and also a disinfecting agent containing such protozoa.. .
Microrna inhibition for the treatment of inflammation and myeloproliferative disorders
The present disclosure relates to the finding that microrna-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microrna-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of cutl1, arnt1, picalm, jarid2, pu.1, csf1r, hif1α, sla, cepbβ, and bach1, and the like..
California Institute Of Technology
Compounds for inhibiting cell proliferation in egfr-driven cancers
Wherein the variables are as defined herein.. .
Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
And w, z, xy, ry1, ry2 and ry3 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers..
Fused heterocyclic compound, preparation method therefor, pharmaceutcial composition, and uses thereof
Disclosed are a fused heterocyclic compound, a preparation method therefor, a pharmaceutical composition, and uses thereof. The fused heterocyclic compound is shown in formula i, formula ii, or formula iii.
Shanghai Yingli Pharmaceutical Co., Ltd.
Chromene derivatives substituted by alkoxide as inhibitors of the tcr-nck interaction
And that present the capacity to inhibit the proliferation of lymphocytes mediated by the nck interaction with tcr, so that the present invention also relates to the use of these compounds for the treatment of diseases or conditions where said interaction triggers a complication such as transplant rejection reactions, immune or autoimmune diseases, inflammatory diseases or proliferative diseases.. .