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Proliferation patents



      
           
This page is updated frequently with new Proliferation-related patent applications. Subscribe to the Proliferation RSS feed to automatically get the update: related Proliferation RSS feeds. RSS updates for this page: Proliferation RSS RSS


Date/App# patent app List of recent Proliferation-related patents
03/26/15
20150087614
 Methods and compositions for reducing the proliferation of gram positive bacteria patent thumbnailnew patent Methods and compositions for reducing the proliferation of gram positive bacteria
Provided herein are methods for inducing cell death in a gram positive bacterium and methods for reducing the proliferation of a gram positive bacterium that include contacting a gram positive bacterium with a dye (e.g., an azo dye) and a taro inhibitor. Also provided are methods of treating a subject having a gram positive bacterial infection that include administering to a subject having a gram positive bacterial infection a dye (e.g., an azo dye) and a taro inhibitor.
Massachusetts Eye & Ear Infirmary
03/26/15
20150086527
 Pharmaceutical composition for treatment of corneal endothelial wounds containing angiogenin patent thumbnailnew patent Pharmaceutical composition for treatment of corneal endothelial wounds containing angiogenin
Provided is a pharmaceutical composition for treating corneal endothelium wounds, the composition including angiogenin as an effective ingredient. The present invention relates to a new topical therapeutic use of angiogenin for treatment of corneal endothelium wounds, wherein the angiogenin that is generally known to be involved in angiogenesis activates a pi3k/akt/enos pathway thereof in ocular corneal endothelium to increase migration and proliferation of corneal endothelial cells that are not capable of self-proliferation and to promote prevention and treatment of corneal endothelial cell wounds..
Industry Academic Cooperation Foundation, Hallym University
03/26/15
20150086515
 Imaging-aided gene therapy using mesenchymal stem cells as target-delivery  vehicle patent thumbnailnew patent Imaging-aided gene therapy using mesenchymal stem cells as target-delivery vehicle
Compositions and methods of use thereof encompass engineered mesenchymal stem cells as a vehicle to deliver secreted tissue necrosis factor-rgd4c fusion polypeptides for tumor treatment, thereby reducing side effects of tnf. A reporter gene can be included in vector constructs to monitor the localization and viability of engineered mscs after administration into a recipient animal.
The Board Of Trustees Of The Leland Stanford Junior University
03/19/15
20150080573
 Process for the synthesis of e1 activating enzyme inhibitors patent thumbnailProcess for the synthesis of e1 activating enzyme inhibitors
The present invention provides processes and synthetic intermediates for the synthesis of 4-substituted ((1s,2s,4r)-2-hydroxy-4-{7h-pyrrolo[2,3-d]pyrimidin-7-yl}cyclopentyl)methyl sulfamates, which are e1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with e1 activity.. .
Millennium Pharmaceuticals, Inc.
03/19/15
20150080477
 Methods and compositions for treating arteriosclerotic vascular diseases patent thumbnailMethods and compositions for treating arteriosclerotic vascular diseases
The present invention provides methods and compositions for treating arteriosclerotic vascular diseases by cyclohexenone compounds. In some embodiments, the compound in the methods inhibits pdgf-stimulated smooth muscle cell proliferation or migration.
Golden Biotechnology Corporation
03/19/15
20150080458
 Materials and methods for the treatment of pathological neovascularization in the eye patent thumbnailMaterials and methods for the treatment of pathological neovascularization in the eye
The subject invention provides materials and methods useful in safely and effectively preventing pathological proliferation of blood vessels. The prevention of the over-proliferation of blood vessels according to the subject invention is particularly advantageous for treatment of certain ocular conditions including age-related macular degeneration (amd), retinopathy of prematurity (rop) and diabetic retinopathy.
Florida Atlantic University Research Corporation
03/19/15
20150080372
 Compounds and methods for kinase modulation, and indications therefor patent thumbnailCompounds and methods for kinase modulation, and indications therefor
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on each of b-raf, b-raf v600e and c-raf-1 protein kinase.
Plexxikon Inc.
03/19/15
20150080316
 Functionalized thieno-indole derivatives for the treatment of cancer patent thumbnailFunctionalized thieno-indole derivatives for the treatment of cancer
The invention relates to new functionalized thieno-indole derivatives of formula (i) or (ii) which have cytotoxic activity and are useful in treating diseases such as cancer and cellular proliferation disorders. The invention also relates to the use of these functionalized thieno-indole derivatives in the preparation of conjugates.
Nerviano Medical Sciences S.r.l.
03/19/15
20150079591
 Predicting response to chemotherapy using gene expression markers patent thumbnailPredicting response to chemotherapy using gene expression markers
The present invention provides gene expression information useful for predicting whether a cancer patient is likely to have a beneficial response to treatment with chemotherapy, comprising measuring, in a biological sample comprising a breast tumor sample obtained from the patient, the expression levels of gene subsets to obtain a risk score associated with a likelihood of a beneficial response to chemotherapy, wherein the score comprises at least one of the following variables: (i) recurrence score, (ii) esri group score; (iii) invasion group score; (iv) proliferation group score; and (v) the expression level of the rna transcript of at least one of mybl2 and scube2, or the corresponding expression product. The invention further comprises a molecular assay-based algorithm to calculate the likelihood that the patient will have a beneficial response to chemotherapy based on the risk score..
Nsabp Foundation, Inc.
03/19/15
20150079026
 Controlled release formulations for the induction and proliferation of blood cells patent thumbnailControlled release formulations for the induction and proliferation of blood cells
The absence of regulatory t cells (treg) may underlie disorders including but not limited to autoimmunity, dermatitis, periodontitis and even transplant rejection. Enhancing local numbers of treg through in situ treg expansion or induction is contemplated herein as a treatment option for these disorders.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education
03/12/15
20150073177

Method for inhibiting trypanosoma cruzi


Methods are provided to inhibit proliferation of trypanosoma cruzi with imido-substituted 1,4-naphthoquinones, including novel compounds. Administering an imido-substituted 1,4-naphthoquinone can be used to provide prophylaxis or treatment to a patient in need of treatment against chagas disease..
Howard Univerrsity
03/12/15
20150073047

Benzo lipoxin analogues


Benzolipoxin analogs, methods of their preparation and pharmaceutical compositions containing the compounds are provided. The compounds and compositions are useful in methods for treatment of various diseases, including, inflammation, autoimmune disease and abnormal cell proliferation..
University Of Southern California
03/12/15
20150072981

1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof


Provided herein are compounds according to formulas (i) or (ii) and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancer, abnormal cellular proliferation, angiogenesis, alzheimer's disease, lung disease, osteoarthritis, idiopathic pulmonary fibrosis and neurological conditions/disorders/diseases.. .
Samumed, Llc
03/12/15
20150072939

Lisurid, terguride and derivatives thereof for use in the prophylaxis and/or treatment of fibrotic changes


The present invention relates to the use of 5-ht2 receptor antagonists and in particular of 8-α-ergolines such as lisuride, terguride and the derivatives thereof as 5-ht2b and 5-ht2a receptor antagonists and antioxidants in preferably higher-dosed and preferably continuous use for the treatment, progression prophylaxis and general prophylaxis of organ fibroses and other pathological organ remodeling caused by mesenchymal proliferation. .
Sinoxa Pharma Gmbh
03/12/15
20150072877

Composition for treatment of pancreatic cancer


Disclosed is a composition for treating pancreatic cancer. The composition comprises a pharmaceutically effective amount of an antisense nucleic acid or sirna that inhibits expression of at least one gene selected from the group consisting of son gene, mcm5 gene, wdr5 gene, pbk gene and cenpa gene.
Tokyo Women's Medical University
03/12/15
20150072425

Methods of generating natural killer cells


Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising administering the nk cells produced by the method to an individual having the cancer or viral infection..
Anthrogenesis Corporation
03/12/15
20150072422

Method of enhancing proliferation and/or survival of mesenchymal precursor cells (mpc)


The present invention relates to methods of enhancing proliferation and/or survival of mesenchymal precursor cells (mpc) and/or progeny derived therefrom in vitro or in vivo comprising exposing the mpc or progeny to sdf-1 or analog thereof. The invention also relates to compositions comprising isolated mpcs or progeny derived therefrom and sdf-1 or analogues thereof.
Angioblast Systems, Inc.
03/12/15
20150072416

Metabolite for improving production, maintenance and proliferation of pluripotent stem cells, composition comprising the same, and culturing pluripotent stem cell using the same


According to the present invention, when nicotinamide is added in a culture process for producing pluripotent stem cells from human differentiated cells, it can increase the efficiency of reprogramming and can significantly reduce the time required for induction of reprogramming. It was verified that nicotinamide inhibits the induction of senescence and oxidative stress in the reprogramming process and increases cell proliferation and mitochondrial activity to effectively improve culture conditions for induction of reprogramming.
Korea Research Institute Of Bioscience And Biotech
03/12/15
20150071984

Controlled and localized release of retinoids to improve neointimal hyperplasia


Controlled release vascular implants, such as vascular grafts, stents, wraps, and gels comprising a biocompatible polymer and all trans retinoic acid (atra), or its derivatives, can be used to treat, prevent, or inhibit thrombosis and/or neointimal hyperplasia which may otherwise be induced by prosthetic implantation. In particular, the implants herein can inhibit smooth muscle cell proliferation, neointimal hyperplasia, and upregulate antithrombotic genes and nitric oxide production in the vasculature.
Vesseltek Biomedical Llc
03/05/15
20150065344

Organic composition for use with plants


An organic composition for use as ground covering capable of supporting plant life is presented. The organic composition is a mixture of filtration waste and topsoil, dirt, manure, wood chips, leaves, and/or sand.
03/05/15
20150064700

Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein


A novel family of human mitochondrial rnas, referred to as chimeric rnas, which are differentially expressed in normal, pre-cancer and cancer cells, are described. Oligonucleotides targeted to the chimeric rnas are provided.
Andes Biotechnologies S.a.
03/05/15
20150064196

Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof


These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of bruton's tyrosine kinase (btk), such as inflammatory and/or autoimmune disorder, cell proliferation, rheumatoid arthritis, psoriasis, psoriatic arthritis, transplant rejection, graft-versus-host disease, multiple sclerosis, inflammatory bowel disease, allergic diseases, asthma, type 1 diabetes, myasthenia gravis, hematopoetic disfunction, b-cell malignancies, systemic lupus, erythematosus or other disorders.. .
03/05/15
20150064147

Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation


Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a collagen component..
Allergan, Inc.
03/05/15
20150064139

Cell potency assay for therapeutic potential


The invention provides cell potency assays for measuring, determining, identifying, confirming, or validating the therapeutic potential of a cell population. Cell potency assays may be performed with various types of cells, including stem or progenitor cells, such as, for example, hematopoietic stem or progenitor cells.
Fate Therapeutics, Inc.
03/05/15
20150064134

Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition


The described invention provides compositions and methods for treating asthma, a disease, condition or pathologic process whose progression is characterized by one or more of aberrant fibroblast proliferation and extracellular matrix deposition producing constriction in an airway, airway remodeling, and airway obstruction in lung tissue. The method includes administering a pharmaceutical composition comprising a therapeutic amount of a polypeptide having the amino acid sequence yaraaarqarakalarqlgvaa (seq id no: 1) or functional equivalent thereof, and a pharmaceutically acceptable carrier, wherein the therapeutic amount of the polypeptide is effective to reduce the constriction of small airway dimensions and airway obstruction, treat airway remodeling, or a combination thereof..
02/26/15
20150058171

Online marketplace for services


A method and system of providing for ratings and recommendations made by knowledgeable third parties as to the competency and fitness of a service provider for the particular project for which the service buyer is currently seeking service providers, together with the aggregation of that data with other data (including other ratings for the particular project, ratings made by service buyers after project completion, and all such data with respect to all projects for the service provider), facilitates the matching of highly qualified service providers with projects/jobs. In addition, because the system harnesses the collective wisdom of all peer raters and expert raters and uses methodologies to encourage the proliferation of accurate and useful ratings data with respect to service providers, the system is able to utilize the power of the internet to collect and aggregate these opinions and ratings/rankings in a manner not easily replicable through offline methods.
02/26/15
20150057751

Acellular dermal graft


An acellular dermal graft is provided. The acellular dermal graft may be useful in minimizing side effects caused after transplantation since an environment favorable for formation of new blood vessels and proliferation of autologous tissues is provided by forming a multi-penetration structure in an acellular dermal tissue, removing a basement membrane layer and/or subjecting corners to slope cutting, and transplantation is stably performed within a short transplantation time due to improved extensibility and flexibility of tissues.
L&c Bio Co., Ltd.
02/26/15
20150056703

Fiber scaffolds for enhancing cell proliferation in cell culture


A substrate for culturing cells that includes at least one fiber scaffold adapted to be contained within a disposable or non-disposable bioreactor, wherein the fiber scaffold further includes polymer fibers that have been created by electrospinning, and wherein the orientation of the fibers in the scaffold relative to one another is generally parallel, random, or both.. .
02/26/15
20150056697

Pluripotent stem cells and stimulating and extracting non-embryonic pluripotent stem cells from mammal blood and using reconstituted pluripotent stem cells to treat diseases including chronic obstructive pulmonary disease


Stimulating tissue resident pluripotent stem cells in a manner that the respective subject (e.g., human) acts as its own sterile bioreactor for in vivo stem cell proliferation thus eliminating the need to isolate, cultivate, maintain, proliferate and release stem cells ex vivo. The stimulation mobilizes excess pluripotent stem cells into the peripheral vasculature where the pluripotent stem cells can either migrate to damaged tissues and/or be harvested by simple venipuncture, thus eliminating potential morbidity and mortality elicited from harvesting tissue from solid tissue sites.
Royal Medical Group, Pllc
02/26/15
20150056222

Anti-prlr antibodies and uses thereof


The present invention provides antibodies that bind to prolactin receptor (prlr) and methods of using the same. According to certain embodiments, the antibodies of the invention bind human prlr with high affinity.
Regeneron Pharmaceuticals, Inc.
02/26/15
20150056221

Anti-prlr antibodies and uses thereof


The present invention provides antibodies that bind to prolactin receptor (prlr) and methods of using the same. According to certain embodiments, the antibodies of the invention bind human prlr with high affinity.
Regeneron Pharmaceuticals, Inc.
02/26/15
20150056161

Regeneration of endogenous myocardial tissue


This invention provides a method of treating a disorder of a subject's heart involving loss of cardiomyocytes which comprises administering to the subject a composition comprising an amount of a human stromal derived factor-1 and an amount of a human granulocyte-colony stimulating factor, the composition being administered in an amount effective to cause proliferation of cardiomyocytes within the subject's heart so as to thereby treat the disorder. This invention also provides a method of treating a subject suffering from a disorder of a tissue involving loss and/or apoptosis of cells of the tissue which comprises administering to the subject a composition comprising an amount of an agent which induces phosphorylation and/or activation of protein kinase b, or an agent which induces phosphorylation and/or activation of an extracellular signal-regulated protein kinase, or an agent which induces activation of cxcr4..
The Trustees Of Columbia University In The City Of New York
02/19/15
20150051558

Composition and corneal proliferation


Disclosed herein in exemplary embodiments are methods and compositions for repairing or treating a defected cornea in a patient in need. The methods and compositions including, for example, administering a dose of a composition to the patient, wherein the composition comprises may be administered to an intraocular area of the patient via a container having a spout for ophthalmic delivery.
University Of Central Florida Research Foundation, Inc.
02/19/15
20150051208

Pyridinones


Wherein the groups r1 to r3 and x1 through x6 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament..
02/19/15
20150051154

Alkylating agents


The present invention relates to a novel class of alkylating agents comprising a thieno-indole moiety linked to a dna-binding moiety, which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical composition containing them.
Nerviano Medical Sciences S.r.l.
02/19/15
20150051145

Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders


The invention provides 1,3-diphenylprop-2-en-1-one derivatives and pharmaceutical compositions comprising the same for treating liver disorders, in particular those requiring the reduction of plasma level of biochemical markers such as aminotransferases. The 1,3-diphenylprop-2-en-1-one derivatives of general formula (i) have hepatoprotective properties and can be used in methods for treating liver disorders involving the pathological disruption, inflammation, degeneration, and/or proliferation of liver cells, such as liver fibrosis or fatty liver disease..
Genfit
02/19/15
20150050744

Diagnostic agent and diagnostic irritable bowel syndrome induced by abnormal proliferation of enterobacteria


[selected drawing] none. .
02/19/15
20150050407

Mixed lactic acid bacterial culture fluid composition for delayed ripening of kimchi and making kimchi using same


Provided are: a culture fluid composition for delaying the ripening of kimchi, which contains a mixed lactic acid bacterial culture fluid with which a culture fluid containing six types of lactic acid bacteria is mixed to be capable of specifically inhibiting the proliferation of lactic acid bacteria in fermented kimchi; vitamin b1; and lactic acid and a method for making kimchi using same for delaying the ripening of kimchi.. .
Ourhome Co.,ltd.
02/19/15
20150050279

B-cell receptor complex binding proteins containing t-cell epitopes


The present invention relates to a polypeptide comprising a) a binding peptide binding to at least one protein selected from the group consisting of cd22, cd19, cd20, and cd21, and b) an immunogenic peptide comprising at least one t-cell epitope for use in vaccination of a subject against b-cell hyperproliferation or for use in the modulation of the immune response in a subject. The present invention further relates to a polynucleotide and a vector encoding said polypeptide and a host cell comprising the same.
Deutsches Krebsforschungszentrum
02/19/15
20150050252

Pluripotent stem cells and stimulating and extracting non-embryonic pluripotent stem cells from mammal blood and using reconstituted pluripotent stem cells to treat diseases including chronic obstructive pulmonary disease


Stimulating tissue resident pluripotent stem cells in a manner that the respective subject (e.g., human) acts as its own sterile bioreactor for in vivo stem cell proliferation thus eliminating the need to isolate, cultivate, maintain, proliferate and release stem cells ex vivo. The stimulation mobilizes excess pluripotent stem cells into the peripheral vasculature where the pluripotent stem cells can either migrate to damaged tissues and/or be harvested by simple venipuncture, thus eliminating potential morbidity and mortality elicited from harvesting tissue from solid tissue sites.
Royal Medical Group, Pllc
02/19/15
20150050239

Substituted pyrazolone compounds and methods of use


The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans..
Sunshine Lake Pharma Co., Ltd.
02/12/15
20150045379

Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof


Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, alzheimer's disease and osteoarthritis), the modulation of cellular events mediated by wnt pathway signaling, as well as genetic diseases due to mutations in wnt signaling components.
Samumed, Llc
02/12/15
20150045374

2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids


The invention provides compounds and salts thereof as d herein. The invention also provides pharmaceutical compositions comprising a compound disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an hiv infection, treating the proliferation of the hiv virus, treating aids or delaying the onset of aids or arc symptoms in a mammal using compounds disclosed herein..
Gilead Sciences, Inc.
02/12/15
20150044770

Method for selective cell attachment/detachment, cell patternization and cell harvesting by means of near infrared rays


The present invention relates to a method for selective cell attachment/detachment, cell patternization and cell harvesting by means of near infrared rays. More particularly, conducting polymers or metal oxides having exothermic characteristics upon irradiation of near infrared light is used as a cell culture scaffold, thus selectively attaching/detaching cells without an enzyme treatment.
Industry-academic Cooperation Foundation Yonsei University
02/12/15
20150044233

Ganglioside gd2 as a marker and target on cancer stem cells


Methods for determining the presence of cancer stem cells by detecting gd2 expression. Also provided are methods for reducing proliferation of cancer stem cells by contacting the cells with a gd2 targeting agent, such as an anti-gd2 antibody or a gd3 synthase inhibitor.
Board Of Regents , The University Of Texas System
02/05/15
20150038708

Substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs as inhibitors of stat protein


In one aspect, the invention relates to substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs, derivatives thereof, and related compounds, which are useful as inhibitors of stat protein activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a stat protein activity dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention..
The Governing Council Of The University Of Toronto
02/05/15
20150038541

Composition and methods for cell modulation


Composition and methods for affecting cell proliferation, metabolism or sensitization, including the potentiation of proteasome inhibitor therapy for the treatment of disease caused by deregulation of ubiquitin-proteasome systems, in a cell or subject. The composition includes a compound in combination with a ubiquitin-proteasome inhibitor.
Aposignal Bioscience Llc
02/05/15
20150037435

Culture medium of adipose-derived stem cell, preparing the same, and composition including the same for promoting hair growth


Provided are a culture medium of an adipose-derived stem cell, a method for preparing the same, and a composition for promoting hair growth, in which the composition includes the culture medium. The adipose-derived stem cell (adsc-t) according to the present invention exhibits long lifespan, improved cell proliferation rate, and extended proliferation period, as compared with a primary adipose-derived stem cell (adsc), and thus, the adipose-derived stem cell (adsc-t) can be usefully used for the study about the adipose-derived stem cell and the mass production of the culture medium of the adipose-derived stem cell.
Changwon National University Industry Academy Cooperation Corps
02/05/15
20150037399

Novel use of pipoxolan and its pharmaceutical composition


The present disclosure concerns the novel use of pipoxolan and its pharmaceutical composition. Pipoxolan is useful therapeutic drugs for pathological conditions caused by vascular smooth muscle cell proliferation and migration to relieve a body appeared vascular injury, cerebrovascular ischemia, intimal hyperplasia, atherosclerotic stenosis, cerebral ischemia, and stroke..
China Medical University
02/05/15
20150037382

Microsphere skin treatment


This application provides a microsphere suitable for tissue engineering that comprises connective tissue growth factor (ctgf). Also provided is a matrix, material or scaffold suitable for tissue engineering that comprises connective tissue growth factor (ctgf) and basic fibroblast growth factor (bfgf).
The Trustees Of Columbia University In The City Of New York
02/05/15
20150037290

Methods of modulating smooth muscle cell proliferation and differentiation


The present disclosure provides methods of inducing smooth muscle cell differentiation. The present disclosure provides genetically modified cells comprising exogenous mir-143 and/or mir-145 nucleic acids; and artificial tissues comprising the genetically modified cells.
The J. David Gladstone Institutes
02/05/15
20150037280

Substituted pyrazolone compounds and methods of use


The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans..
Calitor Sciences, Llc


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Proliferation topics: Proliferation, Cell Proliferation, Differentiation, Cancer Cell, Antibodies, Progesterone, Specificity, Cancer Cells, Antimicrobial, Lymphocyte, Cell Differentiation, Homogeneous, Amino Acids, Wound Healing, Epithelial

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