Proliferation

Proliferation-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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Differential cerebrospinal fluid reactivity to pfdn5-alpha for detection of b-cell acute lymphoblastic leukemia
Amrita Vishwa Vidyapeetham
May 18, 2017 - N°20170138948

A method of managing treatment in a patient with b-cell acute lymphoblastic leukemia (b-all) for central nervous system (cns) leukemia is disclosed. The method comprises obtaining cerebrospinal fluid (csf) from the patient, obtaining a cell proteome including pfdn5-α from the patient, detecting reactivity of csf against the pfdn5-α, comparing reactivity profile of csf against ...
Methods and compositions for labeling nucleic acids
Life Technologies Corporation
May 18, 2017 - N°20170137866

The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. Certain methods are provided that include a [3+2] cycloaddition between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent attached to a label. Other methods are provided that include a staudinger ligation between a nucleotide analogue incorporated into a nucleic ...
Apoptosis inducer
Nitto Denko Corporation
May 18, 2017 - N°20170137825

The purpose of the present invention is to provide: a composition for effectively inducing apoptosis and/or proliferation inhibition in cells; and a method in which the composition is used. The present invention relates to: an agent for inducing apoptosis, which contains a gst-π-inhibiting drug and a rb1cc1-inhibiting drug as active ingredients; a pharmaceutical composition ...
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Targeting micrornas for the treatment of liver cancer
Rosetta Genomics Ltd.
May 18, 2017 - N°20170137811

Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a mirna. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a mirna. Certain ...
Surface modification methods for biomedical scaffolds
The Royal Institution For The Advancement Of Learning/mcgill University
May 18, 2017 - N°20170137588

Many different substrates are used in tissue engineering as platforms to enhance cell attachment, proliferation and activity, either in-vitro, to multiply specific cell lines, or in-vivo, to induce shorter healing time of injured or missing tissue. However, their hydrophobicity and lack of specific functionalities make them non-ideal for cell adhesion and growth. Treating the surfaces by exposing them to a ...
Inhibitors of e1 activating enzymes
Millennium Pharmaceuticals, Inc.
May 18, 2017 - N°20170136024

This invention relates to compounds that inhibit e1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
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  • 113+ full patent PDF documents of Proliferation-related inventions.
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Treatment and prognostic monitoring of cancerous proliferation disorders using hedgehog pathway inhibitors
Hedgepath Pharmaceuticals, Inc.
May 18, 2017 - N°20170136011

The present invention concerns methods for treating a proliferation disorder, such as prostate cancer, basal cell carcinoma, lung cancer, and other cancers, using an inhibitor of the hedgehog pathway (hhp); and methods for monitoring subjects undergoing such treatments based on biomarkers and other criteria predictive of efficacy.
3-d in vitro model for breast cancer dormancy
New Jersey Institute Of Technology
May 11, 2017 - N°20170131273

Disclosed is a three-dimensional (3-d) in vitro model for studying and subsequently treating cancer dormancy. The model is specifically useful in studying breast cancer and may be used for drug discovery because it maintains the breast cancer cells in a dormant state, unlike conventional two-dimensional (2-d) tissue culture plastic (tcp). Tumor-forming breast cancers cells were seeded on the 3-d model ...
Compositions and methods to activate or inhibit toll-like receptor signaling
Yale University
May 11, 2017 - N°20170130228

The present invention includes compositions and methods of inhibiting or activating tlr7 signaling. In one aspect, a composition includes an inhibitor of tlr7 signaling is described, where the inhibitor of tlr7 signaling is a tlr7 inhibitory oligonucleotide, a tlr7 antibody, or a tlr7 antagonist. In another aspect, a composition and method are described for preventing and treating viral infection of ...
Use of materials incorporating microparticles for avoiding the proliferation of contaminants
Pylote
May 11, 2017 - N°20170130027

A solid material including a matrix, dispersed in which are microparticles of at least one antimicrobial agent for preventing, limiting and/or eliminating the contamination of the material and/or the contamination of a composition which is in contact with the material for at least a given time, and/or preventing, eliminating and/or slowing down the formation of biofilms ...
Compounds comprising 1,1a,2,5a-tetrahydrospiro[indole-3,2a-pyrrole]-2,5a-dione system as inhibitors p53-mdm2 protein-protein interaction
Adamed Sp. Z O.o.
May 11, 2017 - N°20170129903

A spirooxoindole compound represented by the formula selected from the group consisting of formula (ia) and (ib), wherein all symbols are as defined in the description. The compound can find use in a method of prevention and/or treatment of diseases selected from the group consisting of cancer, immune diseases, inflammatory conditions, allergic skin diseases associated with excessive proliferation, and ...
4-substituted-2-(5-substituted-1h-indol-2-yl)phenol derivatives, methods for preparing the phenol derivatives and pharmaceutical ...
Adamed Sp. Z O.o.
May 11, 2017 - N°20170129879

Wherein x is selected from the group consisting of hydrogen, halogen, a cyano group, a trifluoromethyl (cf3) group, an amidine (c(═nh)nh2) group, and a 5-methyl-1,2,4-oxadiazole group, y is selected from the group consisting of hydrogen, halogen, a phenyl group substituted with one or two substituents selected from the group consisting of halogen, methoxy, nitro, trifluoromethyl, and ...
Medicinal composition inhibiting neovascularization proliferation factor
Adamed Sp. Z O.o.
May 11, 2017 - N°20170128449

In one or more embodiments, a pharmaceutical composition contains as an active ingredient a low molecular weight compound that is able to suppress the expression of vegf gene in cells or to reduce the production of vegf protein from cells. In one or more embodiments, a pharmaceutical composition contains as an active ingredient a compound expressed by the following formula (...
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Micropropagation of alexandrian laurel (danae racemosa l)
North Carolina A&t State University
May 11, 2017 - N°20170127674

Alexandrian laurel (danae racemosa l.) is a highly demanded evergreen shrub. However, seed germination often takes up to 12 to 18 months with a germination rate of only about 20%. Also, due to its slow-growth rate, it typically takes up to six years to produce a saleable one-gallon size plant. Germinating seeds in the presence of cytokinins and/or auxins increased in vitro ...
Antibody/drug conjugates and methods of use
Esperance Pharmaceuticals, Inc.
May 04, 2017 - N°20170121370

The invention relates to conjugates that bind to targets, methods of using conjugates that bind to targets and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies that express a target.
Inhibitors of metastasis
North Carolina State University
May 04, 2017 - N°20170121369

The present invention relates to methods and compounds for treating or preventing cancer. Methods and compositions provided include including inhibiting or suppressing the development, maintenance, and proliferation of cancers, including blocking or inhibiting cancer cell metastasis.
2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cdk inhibitors and uses thereof
Sunshine Lake Pharma Co., Ltd.
May 04, 2017 - N°20170121323

The invention provides compounds as cdk small-molecule inhibitors and uses thereof, the compounds can be used for treating inflammation and cell proliferation diseases. The novel compound of the invention is a powerful cyclin-dependent kinase 4 (cdk 4) or cyclin-dependent kinase-6 (cdk 6) inhibitor.
Auristatin derivatives and conjugates thereof
Sunshine Lake Pharma Co., Ltd.
May 04, 2017 - N°20170121282

And the use of such peptides in making immunoconjugates (i. E antibody drug conjugates) also described herein are immunoconjugates (i. E antibody drug conjugates) comprising such novel compound linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the ...
Method of making an adjunct to potentiate blocking of ribosomal functions in tumor cells and ...
Sunshine Lake Pharma Co., Ltd.
May 04, 2017 - N°20170119835

A method of obtaining one or more fractions from a plant material of withania somnifera (ws) is disclosed. The method includes subjecting the plant material to hydro-alcoholic extraction in presence of a water-insoluble solvent to obtain at least one extract. The method further includes subjecting the at least one extract obtained from the hydro-alcoholic extraction to at least one of ...
Anticancer nano-silver composition for treatment of lung cancer, and preparation method and use thereof
Changsha Digu Nano Biotechnology Co., Ltd.
May 04, 2017 - N°20170119818

The present invention provided an anticancer nano-silver composition for the treatment of lung cancer. The composition contains spherical nano-silver powder 12-200 mg/kg, pharmaceutically acceptable dispersing agent carbomer 700-800 mg/kg, triethanolamine 700-800 mg/kg, glucose 2. 8-3. 2 g/kg, and purified water as the diluent; of the spherical nano-silver powder, the purity of silver is ≧99. 99% and the particle size ...
Anti-angiogenesis compound, intermediate and use thereof
Guangzhou Kangrui Biological Pharmaceutical Technology Co., Ltd.
May 04, 2017 - N°20170119768

Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula i, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting vegfr2. The compound can be used for treating diseases, such as wet macular degeneration, inflammation, malignant tumor and the like, caused by abnormity of ...