This page is updated frequently with new Proliferation-related patent applications.
| Recombinant l-asparaginase from zymomonas|
The present invention relates to the construction and optimization of synthetic genes from the zymomonas mobilis l-asparaginase gene, the method for cloning same and expression thereof in escherichia coli. The purpose of the production of said enzyme is for producing high levels of a novel l-asparaginase that can be used in l-asparaginase-based pharmaceutical compositions for treating cancer, tumours and diseases involving cell proliferation, as well as for other medical applications..
Coppe/ufrj, Instituto Alberto Luiz Coimbra De PÓs- GraduaÇÃo E Pesquisa De Engenharria
| Activation and expansion of t-cells using an engineered multivalent signaling platform as a research tool|
Provided are a system and methods for selectively inducing expansion of a population of t cells in the absence of exogenous growth factors, such as lymphokines, and accessory cells for research purposes. The cell based expansion system and methods permit the long-term growth of ctls, preferably human ctls.
The Trustees Of The University Of Pennsylvania
| Culture medium for hematopoeitic stem cells and the applications thereof as well as the stem cells culture method|
The present invention discloses a culture medium for hematopoietic stem cells and the applications thereof as well as the stem cells culture method, which adopts amino acids, vitamins, salts, lipids, protein polypeptides and cytokines, together with one or several of trace elements, small organic molecules, hematopoietic stem cell proliferation agents, plant extracts and animal tissue cell extracts, to compose the hematopoietic stem cell culture medium, which can quickly proliferate different species of cd34+ cells, and improve both the proliferation speed and telomere length of cd34+ cells significantly; also, hematopoietic stem cells cultured in the hematopoietic stem cell culture medium described in the present invention may keep their cell functions as well, achieve the functions include but not limited to anti-tumor, anti-aging, and extending lives, thus having a pretty good application prospect.. .
China Life Science Technology Group Limited
| Short peptide-based therapeutic agent and medicinal composition including the same for inhibiting activities of cancer cells|
The present invention relates to a short peptide-based therapeutic agent and a medicinal composition including the same for inhibiting activities of cancer cells, which includes at least one short peptide listed as seq id nos: 1 and 2, either of which is unglycosylated and has no more than 40 amino acid residues, thereby specifically reducing or inhibiting activities of cancer cells such as the cancer cell proliferation, cancer stemness, cell migration, cancer cell invasion, metastasis or drug resistance.. .
National Cheng Kung University
| Method to induce neovascular formation and tissue regeneration|
The present invention relates, e.g., to a method for inducing arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or for inducing mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte, comprising administering to a cell or tissue in need thereof a dose of a polynucleotide that encodes a vascular endothelial growth factor (vegf), or that encodes a polypeptide comprising an active site of the vegf. The coding sequence is operably linked to an expression control sequence; and the dose is sufficient to induce arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or to induce mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte.
Fundacion Universitaria Dr. Rene G. Favaloro
| Composition and uses of galectin antagonists|
The present invention is directed to methods and compositions for augmenting treatment of cancers and other proliferative disorders. In particular embodiments, the invention combines the administration of an agent that inhibits the anti-apoptotic activity of galectin-3 (e.g., a “galectin-3 inhibitor”) so as to potentiate the toxicity of a chemotherapeutic agent.
La Jolla Pharmaceutical Company
| Novel use of sigma-1 receptor agonist compounds|
The present invention is directed to compositions and methods for the prevention, inhibition, and/or treatment of progressive fibrosis present in various fibroproliferative disorders. In particular, embodiments of the present invention relate to the use of sigma-1 receptor agonists for use in the treatment or prevention of progressive fibrosis characterized by the overproliferation of ecm producing cells, e.g.
|Antibody and antibody-containing composition|
For many diseases due to microbes or the like, proliferation of microbes themselves is a cause of a symptom. However, there were cases where a substance released by the microbes is a cause of a symptom.
Immortal Spirit Limited
|Biocompatible smart responsive scaffold having interconnected pores|
A polymeric scaffold contains pendant liquid crystal side chains and has fully interconnected pores. Such a polymeric scaffold will preferably be 3d in nature and elastomeric, biocompatible and biodegradable.
Kent State University
|Method for preparing medicinal herb composition having atopic immune system strengthening and anticancer effects|
Disclosed is a method for preparing an herbal composition having atopic immune system strengthening and anticancer effects, wherein the herbal composition contains siberian ginseng, fish mint, manchurian wild rice, dried ginger, cinnamon bark, jujube, and citrus peel. The herbal composition, obtained by the method provided, is effective at scavenging reactive oxygen species (ros), promoting the proliferation of normal cells without toxicity, and inhibiting the proliferation of colon cancer cells without serious toxicity, based on the results of tests conducted at the blue-bio industry regional innovation center, dong-eui university, busan..
Compositions and methods for preventing the proliferation and epithelial-mesenchymal transition of epithelial cells
Compositions and preparations of fetal support tissue that prevent or reduce the proliferation and epithelial-mesenchymal transition (emt) of epithelial cells, wherein the epithelial cells may be human epithelial cells and the human epithelial cells may be conjunctival, retinal, corneal, limbal, or renal epithelial cells. Methods of preventing or reducing the proliferation, cell migration, and emt of epithelial cells in an individual in need thereof, wherein the epithelial cells may be human epithelial cells and the human epithelial cells may be conjunctival, retinal, corneal, limbal, or renal epithelial cells.
Gene defects and mutant alk kinase in human solid tumors
Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of anaplastic lymphoma kinase (alk) kinase with part of a secondary protein have been identified herein in human solid tumors, e.g. Non-small cell lung carcinoma (nsclc).
Cell Signaling Technology, Inc.
Human igm antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system
Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of the central nervous system that are of viral, bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapten, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof.
O-phenyl chalcone compounds and preparation method and use thereof
Disclosed are an o-phenyl chalcone compounds and preparation methods and uses thereof. The o-phenyl chalcone compounds are capable of inhibiting the aggregation of microtubules in tumor cells and influencing the mitosis of the cells, and have a high antitumor activity.
Sun Yat-sen University
4-substituted pyrrolo[2,3-d]pyrimidine compound and use thereof
The activity experimental results of the invention show that the new compound has obvious effect and activity in inhibition of janus kinases, jak-stat, cell proliferation of human lymphocytoma, and rheumatoid arthritis.. .
Drug for treating corneal endothelium by promoting cell proliferation or inhibiting cell damage
Provided is an agent for treating or preventing a corneal endothelial disorder wherein cell proliferation is required. More specifically, provided is an agent for treating or preventing a corneal endothelial disorder, wherein cell proliferation is required, said agent comprising a p38map kinase inhibitor.
Use of psoralen derivatives and combination therapy for treatment of cell proliferation disorders
Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a dna cross-linking motif to cancer cells, applying a psoralen or a derivative thereof and lapatinib, or applying a psoralen or derivative thereof and neratinib, to a subject and further applying initiation radiation energy form an energy source.. .
Stem cells derived from pure chorionic trophoblast layer and cell therapy comprising same
The present disclosure relates to stem cells derived from a pure chorionic trophoblast layer (chorionic trophoblast layer without villi, ct-v), which is a part of the tissues of the placenta, and cell therapy comprising same. Stem cells derived from a pure chorionic trophoblast layer according to the present invention exhibit uniform growth characteristic, and superb proliferation and differentiation characteristics compared to the conventional stem cells derived from the whole placenta, and particularly, exhibit excellent differentiation into cartilage cells, thus can be effectively used in cell therapy for treating cartilage damage, deficiency and such, and as a composition for tissue regeneration..
Samsung Life Public Welfare Foundation
Method for regulating cell proliferation
The present invention provides a composition for regulating cell proliferation comprising a peptide having a partial amino acid sequence of bbf2h7 or an antibody capable of binding to the peptide. The problem has been solved by preparation of the peptide having a partial amino acid sequence of bbf2h7 which has a cell proliferation activity..
N-heterocyclic carbene gold complexes with anticancer properties and methods of use thereof
Monomeric gold(i) complexes as anticancer agents. The gold(i) complexes are coordinated to mixed ligands: one n-heterocyclic carbene ligand and one monodentate dithiocarbamate-based ligand.
King Fahd University Of Petroleum And Minerals
Novel compositions, uses and methods for making them
Generally, the present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same..
Composite synthetic nanofibrous scaffolds and articles thereof
A synthetic scaffold that comprises a population of nanofibers that include collagen and an anti-thrombotic glycan is provided. In addition, a method of making the synthetic scaffold is provided.
3m Innovative Properties Company
Compositions and manipulating pim-1 activity in circulatory system cells
The invention provides compositions (e.g., pharmaceutical compositions) comprising nucleic acids encoding the serine/threonine kinase pim-1, and methods for making and using them; including methods for inducing cellular proliferation, and protecting cardiac cells from hypoxia and cellular apoptosis. The invention provides compositions (e.g., pharmaceutical compositions) comprising nucleic acids encoding pim-1, and methods for enhancing the regenerative potential of stem cells in the heart..
San Diego State University (sdsu) Foundation
Stem cells derived from basal portion of chorionic trophoblast layer and cell therapy comprising same
The present disclosure relates to stem cells derived from the basal portion of the chorionic trophoblast layer (bct), which is a part of the issues of the placenta, and cell therapy comprising same. Stem cells derived from the basal portion of the chorionic trophoblast layer according to the present invention exhibit uniform growth characteristic, and superb proliferation and differentiation characteristic as compared with the conventional stem cells derived from the full placenta or other tissues, and exhibit excellent tissue regeneration effect in an animal model, thus can be effectively used in cell therapy..
Samsung Life Public Welfare Foundation
Use of mir-494 to modulate trail-induced apoptosis through bim down-regulation
Methods and compositions for inhibiting tumorigenicity both in vitro and in vivo in a subject in need thereof, comprising administering an effective amount of an anti-mir-494 nucleic acid construct sufficient to target one or more tumor suppressor genes (tsgs) are described. Activation of the erk1/2 pathway is a major determinant of diverse cellular processes and cancer development and is responsible for the transcription of several important mirnas.
Ohio State Innovation Foundation
Neutralizing prolactin receptor antibody mat3 and its therapeutic use
The present invention is directed to the neutralizing prolactin receptor antibody mat3, and antigen binding fragments, pharmaceutical compositions containing them and their use in the treatment or prevention of benign disorders and indications mediated by the prolactin receptor such as endometriosis, adenomyosis, non-hormonal female contraception, benign breast disease and mastalgia, lactation inhibition, benign prostate hyperplasia, fibroids, hyper- and normoprolactinemic hair loss, and cotreatment in combined hormone therapy to inhibit mammary epithelial cell proliferation and for the treatment and prevention of antiestrogen-resistant breast cancer. The antibody of the invention blocks prolactin receptor-mediated signalling..
Bayer Intellectual Property Gmbh
Compositions and methods for increasing telomerase activity
The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations.
Telomerase Activation Sciences, Inc.
1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
Provided herein are compounds according to formulas (i) or (ii) and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancer, abnormal cellular proliferation, angiogenesis, alzheimer's disease, lung disease, osteoarthritis, idiopathic pulmonary fibrosis and neurological conditions/disorders/diseases.. .
3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
Or a pharmaceutically acceptable salt thereof, wherein r1, r2a, r2b and r3-r7 are herein. The invention is also directed to compositions containing a compound of formula (i) and to the use of such compounds in the inhibition of mutant idh proteins having a neomorphic activity.
Novel imidazolidine-2,4-dione derivatives
These compounds have anti-proliferative activity and are useful for treating pathological states and diseases linked to an abnormal cell proliferation, such as cancer.. .
Novel imidazolidine-2,4-dione derivatives
The compounds have anti-proliferative activity and are useful for treating pathological states and diseases linked to an abnormal cell proliferation such as cancer.. .
Traditional chinese medicine mulberry leaves polysaccharide and eucommia polysaccharide immunostimulant and application thereof
A traditional chinese medicine immunopotentiator prepared from mulberry leaves polysaccharide and eucommia polysaccharide. The immunopotentiator can stimulate proliferation of chicken lymphocytes in vitro.
Jiangsu Agri-animal Husbandry Vocational College
Alginate biomaterials for the treatment of hepatic disorders
The present invention relates to methods for the treatment of hepatic disorders in a subject in need thereof. More specifically, the methods of the invention are based on the administration, preferably, systemic administration, of a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof.
Ben-gurion University Of The Negev Research And Development Authority
Biguanide derivative, a preparation method thereof, and a pharmaceutical composition containing the biguanide derivative as an active ingredient
A biguanide derivative compound with n1-n5 substitution, which is represented by formula 1, or a pharmaceutically acceptable salt thereof a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of ampkα and inhibition of cancer cell proliferation in a low dose, compared to conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc..
Immunomet Therapeutics Inc.
Antiseptic compositions, methods and systems
Antiseptic compositions comprising at least one salt of edta are disclosed. These compositions have broad spectrum antimicrobial and antifungal activity and they also have anticoagulant properties.
Multi-functional chamber housing a biological component
The present invention relates to the field of extracorporeal liver perfusion and, more particularly, to the design of a chamber in which a biological component can be housed to form e.g. A bio-artificial liver (bal).
University College London
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