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Proliferation patents



      
           
This page is updated frequently with new Proliferation-related patent applications. Subscribe to the Proliferation RSS feed to automatically get the update: related Proliferation RSS feeds. RSS updates for this page: Proliferation RSS RSS


Date/App# patent app List of recent Proliferation-related patents
11/13/14
20140336187
 Methods for treating leishmaniasis patent thumbnailMethods for treating leishmaniasis
Methods are provided to inhibit proliferation of leishmania parasites, and in particular leshmania donovani with imido-substituted 1,4-naphthoquinones, including novel compounds. Administering an imido-substituted 1,4-naphthoquinone can used to provide prophylaxis or treatment to a patient in need of treatment against leishmaniasis disease..
11/13/14
20140336182
 Aurora kinase modulators and method of use patent thumbnailAurora kinase modulators and method of use
Wherein a1-8, d′, l1, l2, r1, r6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases.
11/13/14
20140336143
 Treatment of ebv and khsv infection and associated abnormal cellular proliferation patent thumbnailTreatment of ebv and khsv infection and associated abnormal cellular proliferation
A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with epstein-barr virus (ebv), is provided that includes administering an effective amount of a 5-substituted uracil nucleoside or its pharmaceutically acceptable salt or prodrug, optionally in a pharmaceutically acceptable diluent or excipient.. .
11/13/14
20140336135
 Novel use of rhododendrin patent thumbnailNovel use of rhododendrin
The present invention relates to a novel use of rhododendrin, and more particularly to a composition for antioxidant purposes or for the prevention or treatment of hyperproliferative skin disorders, which comprises rhododendrin as an active ingredient; and a method for inhibiting reactive oxygen species or for preventing and treating a hyperproliferative skin disorder, which comprises administering an effective amount of rhododendrin to a subject in need thereof. Rhododendrin is not cytotoxic and has an excellent effect of eliminating a large amount of reactive oxygen species (ros) generated by tnf-α/ifn-γ or uv light, and thus is effectively used to prepare an antioxidant cosmetic composition or an antioxidant food composition.
11/13/14
20140335066
 Lactobacillus plantarum inducia dsm 21379 as enhancer of cellular immunity, hypocholesterolemic and anti-oxidative agent and antimicrobial agent against clostridium difficile patent thumbnailLactobacillus plantarum inducia dsm 21379 as enhancer of cellular immunity, hypocholesterolemic and anti-oxidative agent and antimicrobial agent against clostridium difficile
A microorganism strain lactobacillus plantarum inducia dsm 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L.
11/06/14
20140329900
 Small molecule inhibitors of stat3 with anti-tumor activity patent thumbnailSmall molecule inhibitors of stat3 with anti-tumor activity
The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of stat3 signaling, stat3 dimerization, stat3-dna binding, stat5-dna binding, and/or aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The compounds of the invention include, but are not limited to, nsc 74859 (s31-201), nsc 42067, nsc 59263, nsc 75912, nsc 11421, nsc 91529, nsc 263435, and pharmaceutically acceptable salts and analogs of the foregoing.
11/06/14
20140329871
 Small molecule anti-fibrotic compounds and uses thereof patent thumbnailSmall molecule anti-fibrotic compounds and uses thereof
And pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis or dysproliferation.. .
11/06/14
20140329811
 Methods of modulating cell proliferation and cyst formation in polycystic kidney and liver diseases patent thumbnailMethods of modulating cell proliferation and cyst formation in polycystic kidney and liver diseases
The present invention provides a method for preferentially reducing the proliferation of cystic epithelial cells in the kidney or bile duct in a mammal in need thereof by administering a 20-hete synthesizing enzyme inhibitor or a 20-hete antagonist to the mammal in an amount sufficient to preferentially reduce the proliferation of cystic epithelial cells over normal epithelial cells such as tubule epithelial cells in the kidney or bile duct. The present invention also provides a method for preventing or treating autosomal dominant polycystic kidney disease (adpkd), autosomal recessive polycystic kidney disease (arpkd), arpkd associated congenital hepatic fibrosis, arpkd associated caroli's disease, or cholangiocarcinoma in a mammal in need thereof by administering a 20-hete synthesizing enzyme inhibitor or a 20-hete antagonist to the mammal in an amount sufficient to prevent or treat the disease..
11/06/14
20140328841
 Anti-ceacam1 recombinant antibodies for cancer therapy patent thumbnailAnti-ceacam1 recombinant antibodies for cancer therapy
Provided herein are recombinant monoclonal antibodies and antigen-binding portions thereof useful in inhibiting ceacam1 in tumor cells, and methods of their use in anti-tumor proliferation and invasiveness therapies, such as the treatment of cancer, particularly pancreatic cancer.. .
11/06/14
20140328828
 Use of therapeutic compositions comprising hyaluronan and therapeutic antibodies patent thumbnailUse of therapeutic compositions comprising hyaluronan and therapeutic antibodies
The present invention relates generally to treatment and prophylactic protocols for cellular disease or disorders, such as diseases and disorders associated with abnormal cellular proliferation. More particularly, the present invention provides uses of compositions comprising therapeutic antibodies and hyaluronan in the treatment or prophylaxis of cellular diseases and disorders..
11/06/14
20140328804
Method for treating or preventing graft versus host disease
A method of treating or preventing graft versus host disease (gvhd) in a subject receiving a graft comprising hematopoietic cells is provided. The method comprises contacting the graft ex vivo with an amount of a myxoma virus effective to inhibit proliferation of t lymphocytes in the graft and to treat or prevent gvhd in the host subject following infusion of the graft into the subject.
11/06/14
20140328800
Method for the biological control of listeria
The invention relates to a method for controlling the proliferation of listeria, with the exception of the treatment methods applied to the human or animal body, characterized in that it uses protozoa of the willaertia magna species, and also to a disinfecting agent containing such protozoa.. .
10/30/14
20140323575
Tyrosine isomers as therapeutic agents
The present invention relates to prevention or treatment of diseases related to abnormal cell proliferation, such as cancer, by administering meta- or ortho-tyrosine to a subject in need thereof, for instance a human subject. More specifically, the present invention provides isomers of tyrosine for its use in the prevention or treatment of a disease and in the preparation of pharmaceutical compositions, methods of treating or preventing diseases, such as cancer and cancer metastases, and pharmaceutical compositions containing meta- and/or ortho-tyrosine..
10/30/14
20140323563
Use of strigolactones and strigolactone analogs for treating proliferative conditions
Compound of formula x wherein p1 is a fused-ring system comprising one 6-membered and two 5-membered rings; v indicates an s or r configuration; or individual isomers or pharmaceutically acceptable salts thereof, or mixtures thereof, in the preparation of an active agent for preventing or inhibiting cell proliferation or for inducing cell death.. .
10/30/14
20140323520
Compositions and methods for increasing proliferation of adult salivary stem cells
The present disclosure provides methods of increasing proliferation of adult salivary stem cells. The methods include contacting adult salivary stem cells in vivo, in vitro, or ex vivo with an aldehyde dehydrogenase (aldh) agonist.
10/30/14
20140323450
Combination compositions and methods of treatment
The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as methods of modulating cellular proliferation processes, and methods of treating disease, disorders, and symptoms thereof.. .
10/30/14
20140323426
Use of opioid antagonists to attenuate endothelial cell proliferation and migration
The invention provides methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that associated with angiogenesis, using opioid antagonists, including, but not limited to, those that are peripherally restricted antagonists.. .
10/30/14
20140322809
Use of a rock inhibitor to sustain primary human keratinocytes in a proliferative state
Disclosed herein is the finding that treatment with a rock inhibitor increases proliferation and induces immortalization of primary keratinocytes. Accordingly, provided is a method of immortalizing primary keratinocytes by exposure to a rock inhibitor.
10/30/14
20140322368
Method of reducing and improving the appearance of scar tissue
Scars, stretch marks, keloids, keratosis, and other skin lesions can be ameliorated through topical application of a composition containing a fortified botanical complex inhibiting tryptase and chymase. A flavonoid with antioxidant properties valuable in inflammatory stress; blocking the release of histamine, inhibiting leukocytic elastase and strengthening the protective properties surrounding the extracellular matrix.
10/30/14
20140322273
Strain of exopolysaccharide-secreting lactobacillus plantarum and application thereof
Provided is a strain of exopolysaccharide-secreting lactobacillus plantarum and an application thereof. The deposit number of the strain is cgmcc no.
10/30/14
20140322247
Cell proliferation inhibitors and conjugates thereof
The invention further provides pharmaceutical compositions comprising these compounds and immunoconjugates, and compositions comprising the immunoconjugates or compounds with a therapeutic co-agent, and methods to use these compounds, conjugates and compositions for treating cell proliferation disorders.. .
10/30/14
20140322167
Process for biologically combating pseudomonas
The invention relates to a method for controlling the proliferation of pseudomonas, with the exception of the treatment methods applied to the human or animal body, characterized in that it uses protozoa of the willaertia magna species, and also to a disinfecting agent containing such protozoa.. .
10/30/14
20140322128
Materials and methods useful to induce cell death via methuosis
The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer.
10/23/14
20140315965
Bis-(aryl/heteroaryl)-methylene compounds, pharmaceutical compositions containing same and their use for treating cancer
The present disclosure relates to novel compounds having vitamin d receptor agonist and histone deacetylase inhibitory efficacy as well as methods for reducing or inhibiting the proliferation of cancer cells or for treating cancer.. .
10/23/14
20140315956
Small molecule inhibitors of il-6 and uses thereof
In one aspect, the invention relates to substituted 2-(1h-indol-3-yl)ethanol analogs and substituted 3,3a,8,8a-tetrahydro-2h-furo[2,3-b]indole analogs, derivatives thereof, and related compounds, which are useful as inhibitors of il-6 mediated activation of the jak2/stat3 pathway; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a il6 dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention..
10/23/14
20140315920
Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors
The present invention concerns methods for treating a proliferation disorder, such as prostate cancer, basal cell carcinoma, lung cancer, and other cancers, using an inhibitor of the hedgehog pathway (hhp); and methods for monitoring subjects undergoing such treatments based on biomarkers and other criteria predictive of efficacy.. .
10/23/14
20140315825
Anti-cancer compositions containing wnt decoy receptor
The present invention relates to a composition for preventing or treating cancer comprising wnt decoy receptor. The composition of the present invention or the expression product thereof inhibits cancer generation, growth, proliferation and metastasis, and induces apoptosis of cancer cells, by binding to wnt ligand and blocking ligand-receptor interactions, therefore may be effectively used as an anti-cancer agent..
10/23/14
20140315741
Methods and materials for modulating deubiquitinases and ubiquitinated polypeptides
This document relates to methods and materials involved in modulating deubiquitinases (e.g., usp10 polypeptides) and/or ubiquitinated polypeptides (e.g., tumor suppressor polypeptides or mutant versions of tumor suppressor polypeptides). For example, methods and materials for increasing deubiquitinase (e.g., a usp10 polypeptide) expression or activity, methods and materials for decreasing deubiquitinase (e.g., a usp10 polypeptide) expression or activity, methods and materials for stabilizing tumor suppressor polypeptides (e.g., wild-type p53 polypeptides), methods and materials for de-stabilizing mutant versions of tumor suppressor polypeptides (e.g., mutant p53 polypeptides), and methods and materials for reducing cancer cell proliferation, increasing cancer cell apoptosis, and/or treating cancer (e.g., cancers having reduced levels of wild-type p53 polypeptides or cancers having increased levels of mutant p53 polypeptides) are provided.
10/23/14
20140314824
Porous scaffold for tissue engineering and preparation method thereof
A porous artificial transplant material to replace autogenous bone with excellent biocompatibility, cytocompatibility and biodegradability is provided. More specifically, a porous scaffold for tissue engineering including chitosan/hydroxyapatite-amylopectin (chitosan/hap-ap) and a preparation method thereof are provided.
10/23/14
20140314795
Method and compositions for cellular immunotherapy
The present invention provides methods and compositions to confer and/or augment immune responses mediated by cellular immunotherapy, such as by adoptively transferring genetically modified tumor specific cd8+ t cells in the presence of tumor-specific, subset specific genetically modified cd4+ t cells, wherein the cd4+ t cells confer and/or augment a cd8+ t cells ability to sustain anti-tumor reactivity and increase and/or maximize tumor-specific proliferation of the tumor-specific cd8+ t cells of interest. Pharmaceutical formulations produced by the method, and methods of using the same, are also described..
10/23/14
20140314712
Fusion protein comprising an interleukin 4 and interleukin
The invention is concerned with a fusion protein comprising interleukin 10 and interleukin 4, a nucleic acid molecule encoding such fusion protein, a vector comprising such nucleic acid molecule, and a host cell comprising such nucleic acid molecule or such vector. The invention further pertains to a method for producing such fusion protein.
10/16/14
20140309292
Mutations of histone proteins associated with proliferative disorders
The present application shows the relationship between variations in the amino acid sequence of histone proteins, more specifically the h3.3 protein, and proliferation-associated disorders. Herewith provided are predictive methods, commercial packages, therapeutic methods and screening methods based on this relationship..
10/16/14
20140309259
Derivatives of 1-(substituted sulfonyl)-2-aminoimidazoline as antitumor and antiproliferative agents
The invention provides novel, water-soluble 2-aminoimidazoline derivatives having general formula (i) as well as some precursors of formula (i), which are very potent inducers of g2/m cell cycle arrest. In treated tumor cells, compounds of formula (i) give gene expression profile distinct from known antimitotic agents.
10/16/14
20140309240
Derivatives of 1-(substituted sulfonyl)-2-aminoimidazoline as antitumor and antiproliferative agents
The invention provides novel, water-soluble 2-aminoimidazoline derivatives having general formula (i) as well as some precursors of formula (i), which are very potent inducers of g2/m cell cycle arrest. In treated tumor cells, compounds of formula (i) give gene expression profile distinct from known antimitotic agents.
10/16/14
20140309221
Method of inhibiting hamartoma tumor cells
Dimorpholinopyrimidines are useful for inhibiting growth or proliferation of hamartoma tumor cells. Because the dimorpholinopyrimidines inhibit the growth and proliferation of hamartoma tumor cells they are also useful in treating pten hamartoma tumor syndromes.
10/16/14
20140309195
Small molecules that promote skin regeneration
Provided herein are small molecules for the induction of fibroblast proliferation and increased secretion or production of proteins. The small molecules described herein can be used for the promotion of skin regeneration.
10/16/14
20140309165
Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
The invention provides 1,3-diphenylprop-2-en-1-one derivatives and pharmaceutical compositions comprising the same for treating liver disorders, in particular those requiring the reduction of plasma level of biochemical markers such as amino-transferases. The 1,3-diphenylprop-2-en-1-one derivatives of general formula (i) have hepatoprotective properties and can be used in methods for treating liver disorders involving the pathological disruption, inflammation, degeneration, and/or proliferation of liver cells, such as liver fibrosis or fatty liver disease..
10/16/14
20140308288
Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
An antibody of the invention interacts with human dr5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-dr5 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated.
10/16/14
20140308264
Vegf analogs and methods of use
Modified vegf proteins that inhibit vegf-mediated activation or proliferation of endothelial cells are disclosed. The analogs may be used to inhibit vegf-mediated activation of endothelial cells in angiogenesis-associated diseases such as cancer, inflammatory diseases, eye diseases, and skin disorders..
10/16/14
20140308258
Enhanced microbial strains for the prevention and treatment of methicillin-resistant staphylococcus aureus and methicillin-resistant staphylococcus epidermis infection
The present invention provides enhanced microorganisms useful for inhibiting and/or preventing the proliferation of pathogenic microorganisms such as methicillin-resistant staphylococcus aureus and methicillin-resistant staphylococcus epidermidis.. .
10/16/14
20140308255
Methods and compositions for regulation of cell aging, carcinogenesis and reprogramming
Compositions and methods described herein include somatic cells that are competent for reprogramming and malignant transformation and are characterized by a reduction of the levels of sp100 in the cells, cells having markers of pluripotent stem cells, and methods for preparing same. Methods for reversably regulating aging or reprogramming to pluripotency in a somatic cell involve modulating the expression of sp100 therein.
10/09/14
20140304093
Method and system to promote sales or services with social sales point
The present disclosure is directed towards small modules, web plugins, which may be placed on any influential content which simplify and promote sales by operating as a social sales point (ssp). Ssp's simplify sales by avoiding buyers engaging in any further searches or product comparisons.
10/09/14
20140303727
Device for ear drum repair
A device for use in the repair of an ear drum in a subject in need of such treatment, said device: having a tensile strength youngs modulus between approximately 12.5 and 40 mpa; comprising one or more membrane layers, wherein at least one membrane layer comprises a plurality of pores; and wherein the device can support proliferation, migration and/or adhesion of cells selected from the group comprising at least any one or more of: keratinocytes, fibroblasts, vascular cells, mucosal epithelial cells, and stem cells.. .
10/09/14
20140303212
Method for treating neurodegeneration using a p38mapk inhibitor
Ataxia-telangiectasia (a-t) is a progressive degenerative disorder that results in major neurological disability. In a-t patients, necropsy has revealed atrophy of all cerebellar cortical layers with extensive purkinje and granular cell loss.
10/09/14
20140303197
Methods of treating and preventing leukemia and other cancers of the blood and bone
The present invention relates to preventing and treating leukemia and other cancers of the blood and bone, as well as disorders of the blood, by inhibiting gut-derived serotonin. The inhibition of the gut-derived serotonin is accomplished by inhibiting tph1, an enzyme responsible for the production of gut-derived serotonin.
10/09/14
20140303162
Azabicyclo compound and salt thereof
It is intended to provide a novel azabicyclo compound which exhibits both hsp90 inhibitory activity and cell proliferation inhibitory effect. Specifically disclosed is a compound represented by the following general formula (i) or a salt thereof: wherein x1 represents ch or n; any one of x2, x3 and x4 represents n, and the others represent ch; any one or two of y1, y2, y3 and y4 represent c—r4, and the others are the same or different and represent ch or n; r1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from n, s and o; r2 represents an alkyl group having 1 to 6 carbon atoms, or the like; and r3 and r4 represent —co—r5 or the like..
10/09/14
20140303111
Compositions including triciribine and taxanes and methods of use thereof
This application relates to combination therapies including triciribine and related compounds and taxanes and compositions with reduced toxicity thr the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. .
10/09/14
20140303078
Modulation of pancreatic beta cell proliferation
Work described herein provides, in one embodiment, a method for increasing proliferation or replication of pancreatic beta cells in a subject in need thereof, comprising administering to said subject an effective amount of an agent that increases the level or activity of hepatocellular carcinoma-associated protein td26 (td26), thereby increasing proliferation or replication of pancreatic beta cells. Such an agent may function by, for example, increasing the level of active td26 in the subject or by increasing the functional activity of td26 in the subject..
10/09/14
20140302491
Ex vivo culture, proliferation and expansion of primary tissue organoids
Culture systems and methods for long term culture of mammalian tissues are provided. Tissues include but are not limited to lung alveolar tissue, stomach tissue, pancreas tissue, bladder tissue, liver tissue, and kidney tissue.
10/09/14
20140302057
Inhibitors of metastasis
The present invention relates to methods and compounds for treating or preventing cancer. Methods and compositions provided include including inhibiting or suppressing the development, maintenance, and proliferation of cancers, including blocking or inhibiting cancer cell metastasis..
10/09/14
20140302011
Compositions including triciribine and trastuzumab and methods of use thereof
This application relates to combination therapies including triciribine and related compounds and trastuzumab or a salt thereof and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. .
10/09/14
20140301943
Induction of thyroid iodide-handling gene expression in human cancers
Dual suppression of the map kinase and pi3k/akt pathways showed synergistic or greatly enhanced anti-melanoma cell effects, compared to suppression of a single pathway, including the inhibition of cell proliferation, transformation and invasion, induction of g0/g1 cell cycle arrest and, importantly, cell apoptosis. Remarkably, suppression of either pathway induces the expression of thyroid iodide-handling genes and dual suppression of the two pathways synergistically and robustly induces expression of these genes, accompanied by uptake of radioiodine in the cells.


Popular terms: [SEARCH]

Proliferation topics: Proliferation, Cell Proliferation, Differentiation, Cancer Cell, Antibodies, Progesterone, Specificity, Cancer Cells, Antimicrobial, Lymphocyte, Cell Differentiation, Homogeneous, Amino Acids, Wound Healing, Epithelial

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This listing is a sample listing of patent applications related to Proliferation for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Proliferation with additional patents listed. Browse our RSS directory or Search for other possible listings.
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