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Proliferation patents



      

This page is updated frequently with new Proliferation-related patent applications.




Date/App# patent app List of recent Proliferation-related patents
07/21/16
20160210581 
 Method and  emergency response notification patent thumbnailnew patent Method and emergency response notification
Embodiments of the invention leverage mobile proliferation to enable laypersons to initiate a timely and effective emergency response in case of an emergency, such as a medical emergency, e.g. Cardiac event.
Emergency University, Inc.


07/21/16
20160208250 
 Therapeutic agent  for  corneal  epithelial  disorder patent thumbnailnew patent Therapeutic agent for corneal epithelial disorder
A therapeutic agent for a corneal epithelial disorder, containing a mir-203 inhibitor; an agent for promoting proliferation of corneal epithelial cells, containing a mir-203 inhibitor; a liquid culture medium for use in the manufacture of a corneal epithelial sheet, containing a mir-203 inhibitor; and a method for producing a corneal epithelial sheet, including the step of culturing corneal epithelial cells using a liquid culture medium containing a mir-203 inhibitor. According to the present invention, a therapeutic agent for a corneal epithelial disorder, an agent for promoting proliferation of corneal epithelial cells, a liquid culture medium for use in the manufacture of a corneal epithelial sheet, a method for producing a corneal epithelial sheet, including the step of culturing corneal epithelial cells using the liquid culture medium, and a method for treating a corneal epithelial disorder can be provided.
Senju Pharmaceutical Co., Ltd.


07/21/16
20160208248 
 Neurocalcin delta inhibitors and therapeutic and non-therapeutic uses thereof patent thumbnailnew patent Neurocalcin delta inhibitors and therapeutic and non-therapeutic uses thereof
The present invention relates to an inhibitor of neurocalcin delta (ncald) for use in a method for the treatment or prevention of a patient suffering from a disorder associated with a pathological calcium homeostasis. Furthermore, the present invention refers to the use of such inhibitor of ncald for inducing axon proliferation in vitro and to a method for the differentiation and/or maturation of neuronal stem cells (nscs) in vitro and to the use of such inhibitor of ncald to restore impaired endocytosis being a consequence of disturbed ca2+ homeostasis in synaptic terminals essential for development, maturation and maintenance of synapses and neuromuscular junctions (nmjs)..
UniversitÄt Zu KÖln


07/21/16
20160207891 
 Malignant and non-malignant disease treatment with ras antagonists patent thumbnailnew patent Malignant and non-malignant disease treatment with ras antagonists
The present disclosure describes new inhibitors or antagonists of ras useful for the treatment of conditions resulting from ras-induced or mediated cellular processes, including cellular proliferation, differentiation, apoptosis, senescence, and survival. These cellular processes may be associated with a non-malignant or malignant disease, disorder, or pathological condition.
Pisces Therapeutics, Llc


07/21/16
20160206780 
 Matrix scaffold for three-dimensional cell cultivation, methods of construction thereof and uses thereof patent thumbnailnew patent Matrix scaffold for three-dimensional cell cultivation, methods of construction thereof and uses thereof
This invention provides a matrix scaffold for three-dimensional (3d) cell cultivation, a method of its construction, and its uses. The matrix scaffold results from a crosslinking reaction of a fibroin-like substance prepared by a specific method from silk cocoons or filaments, chitosan and crosslinking agents.
Suzhou Cancercell Biotechnology Co. Ltd


07/21/16
20160206644 
 Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof patent thumbnailnew patent Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof
This application relates to combination therapies including triciribine compounds and epidermal growth factor receptor inhibitor compounds, particularly erlotinib-like compounds and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. .
University Of South Florida


07/21/16
20160206631 
 Oxysterols that activate liver x receptor signaling and inhibit hedgehog signaling patent thumbnailnew patent Oxysterols that activate liver x receptor signaling and inhibit hedgehog signaling
This invention relates, e.g., to compositions comprising oxysterol compounds represented by formula i or formula ii, e.g., comprising one or more of oxy 16, oxy 22, oxy30, oxy 31, oxy35, oxy37, oxy43, oxy44, oxy45 or oxy47. The compounds are shown to be hedgehog pathway inhibiting, and to act as agonists for liver x receptor (lxr).
The Regents Of The University Of California


07/14/16
20160200783 
 Use of multivalent synthetic ligands of surface nucleolin for treating cancer or inflammation patent thumbnailUse of multivalent synthetic ligands of surface nucleolin for treating cancer or inflammation
A method for treating disorders involving deregulation of cell proliferation and/or angiogenesis comprising the administration of an effective amount of a multivalent synthetic compound comprising a support on which at least 3 pseudopeptide units are grafted, said compound being of formula (i).. .
Centre National De La Recherche Scientifique (cnrs)


07/14/16
20160200740 
 Compound for the treatment of human liver cancer and  synthesizing it patent thumbnailCompound for the treatment of human liver cancer and synthesizing it
The compound “2-((4-nitrophenyl)amino)-7,8,9,10-tetrahydro cyclohepta[4,5]thieno[2,3-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-11(6h)-one” and method of synthesizing it, wherein the compound is effective to inhibit the growth and proliferation of human liver cancer cells hepg2. The compound has a higher efficiency to inhibit the growth and proliferation of these cells as it has an inhibitory concentration value (ic50) of 0.7 μg, compared to reference medication doxorubicin that has an (ic50) value of 1.2 μg.

07/14/16
20160199630 
 Methods and devices to prevent premature birth patent thumbnailMethods and devices to prevent premature birth
Methods and devices to affect types, proportion, quantity, distribution, or proliferation of microorganisms within a female reproductive system.. .

07/14/16
20160199535 

Controlled and localized release of retinoids to improve neointimal hyperplasia


Controlled release vascular implants, such as vascular grafts, stents, wraps, and gels comprising a biocompatible polymer and all trans retinoic acid (atra), or its derivatives, can be used to treat, prevent, or inhibit thrombosis and/or neointimal hyperplasia which may otherwise be induced by prosthetic implantation. In particular, the implants herein can inhibit smooth muscle cell proliferation, neointimal hyperplasia, and upregulate antithrombotic genes and nitric oxide production in the vasculature.
Vesseltek Biomedical Llc


07/14/16
20160199383 

5-alkynyl-pyrimidines


R1 to r3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.. .

07/14/16
20160199346 

Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof


The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.. .
Orbital Atk, Inc.


07/07/16
20160198365 

Distributed load management on network devices


This disclosure relates to a system and method for dynamically managing load on network devices in a distributed manner. As the proliferation of data rich content and increasingly more capable mobile devices has continued, the amount of data communicated over mobile operator's networks has exponentially increased.
Cisco Technology, Inc.


07/07/16
20160194718 

Compositions and methods for identification, assessment, prevention, and treatment of cancer using histone h3k27me3 biomarkers and modulators


The present invention relates to methods for identifying, assessing, preventing, and treating cancer (e.g., lymphoid and/or myeloid malignancies such as b-all in humans). A variety of histone h3k27rne3 biomarkers are provided, wherein alterations in the copy number of one or more of the biomarkers and/or alterations in the amount, structure, and/or activity of one or more of the biomarkers is associated with cancer status and indicates amenability to treatment or prevention by modulating h3k27me3 levels.
Dana-farber Cancer Institute, Inc.


07/07/16
20160194611 

Simplified basic media for human pluripotent cell culture


Fully defined media that support pluripotent cell viability, proliferation, cloning, and derivation, as well as methods and compositions including these media are described. Methods for deriving ips cells from adult individuals under defined, xeno-free conditions are also described..
Wisconsin Alumni Research Foundation


07/07/16
20160194348 

Substituted pyrrolo[2,3-d]pyrimidines


This invention relates to compounds that inhibit e1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia..
Millennium Pharmaceuticals, Inc.


07/07/16
20160194311 

Substituted nicotinamide derivatives as kinase inhibitors


The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.. .
Allergan, Inc.


07/07/16
20160194286 

New anti-malarial agents


The present invention is related to a use of pyrazole derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to pyrazole derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation..
University Of Washington


07/07/16
20160193292 

Cell permeable inhibitors of the scaffold protein plenty of sh3 domains (posh) or sh3rfl


Plenty of sii3 (posh) and ink-interacting protein 1 (jip-1) function as a multi-protein scaffold network for tcr-mediated jnk1 activation in cd8+ t-cells. Disruption of the posh/jip-1 complex led to profound defects in the activation of jnk1, as well as deficient activation or induction of the transcription factors c-jun, t-bet and eomesodermin furthermore, disruption of the posh/jip complex in cd8+t-cells resulted in impaired proliferation, decreased cytokine expression and the inability to control tumors.
The Curators Of The University Of Missouri


07/07/16
20160193257 

Human-derived bacteria that induce proliferation or accumulation of regulatory t cells


Species of human-derived bacteria belonging to the clostridia class have been shown to induce accumulation of regulatory t cells (treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases..
School Corporation, Azabu Veterinary Medicine Educational Institution


07/07/16
20160193256 

Human-derived bacteria that induce proliferation or accumulation of regulatory t cells


Species of human-derived bacteria belonging to the clostridia class have been shown to induce accumulation of regulatory t cells (treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases..
School Corporation, Azabu Veterinary Medicine Educational Institution


07/07/16
20160193249 

Treatment of inflammatory diseases by carbon materials


In some embodiments, the present disclosure pertains to methods of treating an inflammatory disease in a subject by administering a carbon material to the subject. In some embodiments, the carbon material selectively targets t cells in the subject.
Baylor College Of Medicine


07/07/16
20160193180 

Composition for preventing and treating immune diseases containing daurinol compound as active ingredient


The daurinol compound according to the present invention exhibits excellent therapeutic effects on arthritis and inflammatory bowel diseases by having an excellent activity in inhibiting the generation of il-17 and tnf-α, which are inflammatory cytokines causing inflammation, and can alleviate transplant rejection by inhibiting the proliferation of alloreactive t cells and increasing regulatory t cells; therefore, the daurinol compound according to the present invention can be used as a pharmaceutical composition capable of treating and preventing immune diseases. In addition, being a natural substance derived from the mongolian medicinal plant haplophyllum dauricum or haplophyllum cappadocicum, the daurinol compound according to the present invention does not cause cytotoxicity and thus may be used as a composition for a functional health food capable of preventing and remedying immune diseases..
The Catholic University Of Korea Industry-academic Cooperation Foundation


06/30/16
20160191472 

System and sending and receiving secret message content over a network


The proliferation of personal computing devices in recent years, especially mobile personal computing devices, has led to increased concerns regarding the safety and security of documents and messages that are sent over networks. Users desire a system that provides for the setting of custom, content-agnostic, permissions at a message, document, and/or sub-document-level through communications networks.

06/30/16
20160188893 

System and applying adaptive privacy controls to lossy file types


The proliferation of personal computing devices in recent years, especially mobile personal computing devices, combined with a growth in the number of widely-used communications formats has led to increased concerns regarding the safety and security of documents and messages that are sent over networks. Users desire a system that provides for the setting of custom access permissions at a file-level or sub-file-level.

06/30/16
20160188887 

System and determining user-defined permissions through a network


The proliferation of personal computing devices in recent years, especially mobile personal computing devices, combined with a growth in the number of widely-used communications formats has led to increased concerns regarding the safety and security of documents and messages that are sent over networks. Users desire a system that provides for the setting of custom, content-agnostic, permissions at a message, document, and/or sub-document-level through a communications network.

06/30/16
20160186268 

Gene defects and mutant alk kinase in human solid tumors


Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of anaplastic lymphoma kinase (alk) kinase with part of a secondary protein have been identified herein in human solid tumors, e.g. Non-small cell lung carcinoma (nsclc).

06/30/16
20160186173 

C-myc antisense oligonucleotides and methods for using the same to treat cell-proliferative disorders


Provided herein are antisense oligonucleotides that can effectively prevent or decrease c-myc protein expression as well as decrease overall rates of cell proliferation in in vitro and mammalian in vivo models of cell proliferative disorders as well as methods for using the same.. .

06/30/16
20160186138 

Natural killer cells and methods for enhancing viability, proliferation and cytotoxicity of same following cryopreservation


The invention provides natural killer cells and improved methods for increasing natural killer cell viability, proliferation and cytotoxicity following cryopreservation.. .

06/30/16
20160185771 

Conjugate of benzofuranone and indole or azaindole, and preparation and uses thereof


The present invention relates to an oxo indirubin or isoindigo derivative, an oxo aza indirubin or isoindigo derivative, and their optical isomers, racemes, cis/trans isomers and pharmaceutically acceptable salts, which can be used for preparing a drug for treating or preventing diseases such as glucose metabolic disorder, inflammatory or autoimmune disease, neurodegenerative disease, a mental illness, tissue proliferation disease or tumors.. .

06/30/16
20160185742 

Method for preparing benzopyran compound and application thereof in treating pulmonary fibrosis


In which: r1 represents hydrogen, c1-c4 alkyl, or various remaining amino acid moieties after removal of an amino group; r2 represents hydrogen, c1-c4 alkyl, or various remaining amino acid moieties after removal of an amino group; r3 represents hydrogen, or c1-c4 alkyl; and n is any integer of 1-4, wherein the benzopyran compound is derived from a broth of streptomyces xiamenensis cgmcc no. 5675 by extraction, separation and purification.

06/30/16
20160185725 

C-met modulators and use


The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-met, kdf, c-kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

06/30/16
20160184333 

Mitochondria-targeted anti-tumor agents


Described are mitochondria-targeted anti-tumor agents, and methods of making and using the same for the treatment of disorders associated with unwanted cell proliferation.. .

06/30/16
20160183519 

Antibiotic treating a sapphire


The instant disclosure is related to a sapphire, including a surface and a silver-containing antibiotic source, wherein the silver-containing antibiotic source forms an antibiotic film covering the surface. The instant disclosure also relates to a sapphire, including a surface, an oxide layer extending from the surface to inside of the surface, and a silver-containing antibiotic source, wherein the silver-containing antibiotic source is distributed in the oxide layer, so as to turn the oxide layer into an antibiotic layer and turn the surface into an antibiotic surface.

06/23/16
20160178648 

Marker for detecting proliferation and treatment capacities of adipose-derived stem cell cultured in medium containing egf or bfgf, and use thereof


The present invention relates to: a composition for detecting a marker for detecting the proliferation capacity or treatment capacity of adipose-derived stem cells cultured in a medium containing epidermal growth factor (egf) or basic fibroblast growth factor (bfgf); and a detection method.. .

06/23/16
20160178278 

Food waste vacuum-drying disposal system


The present invention relates to a food waste vacuum-drying disposal system and, particularly, to a food waste vacuum-drying disposal system, which can be installed in a food waste collection vehicle due to the simple structure thereof and can carry out vacuum-dry disposal of food waste even while moving during food waste collection. The food waste vacuum-drying disposal system of the present invention is a device capable of: sterilizing and drying inputted food waste by heat converted from a light emitted from a heating element inside a vacuum tank; condensing and discharging, as condensed water, evaporated and sublimed gas generated during a drying process; and discharging, in the air, non-condensed gas such that food waste leachate can be disposed at the same time.

06/23/16
20160177261 

Methods of inducing and preventing neurofibromatosis in schwann cells


The invention provides a method of inducing neurofibromatosis type 2 (nf2) in schwann cells. The method comprises contacting the cells with laminin-1 so as to bind α6β1 integrin sufficiently to activate endogenous kinase cdc42-pak; and phosphorylating schwannomin-s518 in the cells by the activated kinase, effectively inactivating.

06/23/16
20160176937 

Short peptides derived from vdac1, compositions and methods of use thereof


The present invention relates to short peptides based on the amino acids sequence of the n-terminal domain of the human mitochondrial protein voltage-dependent anion channel 1 (vdac) and to peptide conjugates having a cell permeability enhancing moiety. The peptides, peptide conjugates and pharmaceutical compositions containing them are useful for treating diseases characterized by cell hyperproliferation or resistance to cell death and in particular, cancer..

06/23/16
20160176876 

2-substituted imidazo[4,5-d]phenanthroline derivatives and their use in the treatment of cancer


The present invention provides 2-substituted imidazo[4,5-d]phenanthroline compounds, which are capable of inhibiting proliferation of one or more renal cancer cells, pancreatic cancer cells, prostate cancer cells, colon cancer cells, leukemia cells, brain cancer/tumour cells or non-small cell lung cancer cells.. .

06/23/16
20160176825 

Kinase inhibitors for the treatment of disease


The invention relates to compounds and their use in the treatment of disease. Novel irreversible inhibitors of wild-type and mutant forms of egfr, fgfr, alk, ros, jak, btk, blk, itk, tec, and/or txk and their use for the treatment of cell proliferation disorders are described..

06/23/16
20160176731 

Apparatus for the purification of unclean water, in particular of wastewater and/or polluted water


The invention regards an apparatus (1) for the purification of unclean water (a), in particular of wastewater and/or polluted water (a), comprising:—at least one container (2), preferably cylindrical, delimiting a reaction chamber (3) arranged to receive a predetermined amount of water (a) to be treated; at least one support (11), preferably at least one free body (11a) not constrained to the apparatus (1), operatively arranged inside the reaction chamber (3) of the container (2) and provided with at least one surface for the formation and/or the proliferation of bacterial colonies in form of films capable of purifying unclean water (a), the support (11) periodically emerging, at least partially, from the water (a) to be treated in order to place the bacterial colonies into contact with the air. The container (2) is movable, in particular rotationally about a predetermined rotation axis (x), for periodically driving the support (11) between an immersed condition, wherein it is totally covered with water (a) to be treated, and an emerged condition, wherein it emerges, at least partially, from the water (a) to be treated..

06/23/16
20160175395 

Use of osteoprotegerin (opg) to increase human pancreatic beta cell survival and proliferation


It is disclosed herein that osteoprotegerin increases human beta cell proliferation and survival. Methods are provided for increasing beta cell proliferation, but contacting a beta cell with an effective amount of osteoprotegrin, a functional fragment, variant or fusion protein thereof.

06/23/16
20160175351 

Cancer treatment


Described herein are methods of inhibiting the proliferation of cancer cells and methods of treating cancer, as well as methods of predicting responsiveness of subjects to certain cancer treatments and methods of identifying subjects as candidates for certain cancer treatments.. .

06/23/16
20160175341 

Hydroxyalkyl starch for the treatment of hematological neoplasms


The present invention relates to hydroxyalkyl starch or a pharmaceutical preparation thereof for the treatment of a hematological neoplasm, especially by effectively reducing proliferation rate of cancer cells and inhibiting cancer cell growth and wherein the hydroxyalkyl starch has a mean molecular weight (mw) above 20 and below 1300 kda and a molar substitution (ms) in the range of from 0.1 to 1.5, wherein the alkylation may be an ethylation, propylation or butylation or mixes thereof; and wherein the alkyl may be further substituted.. .

06/23/16
20160175288 

Macrocyclic lactone compounds and methods for their use


The present invention provides a device for intracorporeal use including an implant or a temporary device and at least one source of a compound myolimus, or a derivative thereof. The present invention also provides a method of inhibiting cell proliferation by local administration of a therapeutically effective amount of a compound myolimus, or a derivative thereof.

06/23/16
20160175278 

Aryl hydrocarbon receptor (ahr) modifiers as novel cancer therapeutics


Provided herein are novel agents that modulate ahr activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis. The agents comprise ahr inhibitors or non-constitutive ahr agonists of formula (i) and (ii) for the inhibition of cancer cell growth and parameters that characterize tumor metastasis, such as tumor cell invasiveness..

06/16/16
20160169863 

Means and methods for assessing increased peroxisomal proliferation


The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation.
Basf Se


06/16/16
20160168205 

Methods and compositions for labeling polypeptides


Synthesis of many proteins is tightly controlled at the level of translation and plays an essential role in fundamental processes such as cell growth and proliferation, signaling, differentiation or death. Methods that allow imaging and identification of nascent proteins allow for dissecting regulation of translation, both spatially and temporally, including in whole organisms.
President And Fellows Of Harvard College


06/16/16
20160166652 

Novel n- and c-terminal substituted antagonistic analogs of gh-rh


There is provided a novel series of synthetic analogs of hgh-rh(1-29)nh2 (seq id no: 1) and hgh-rh(1-30)nh2. Of particular interest are those carrying phac, n-me-aib, dca, ac-ada, fer, ac-amc, me-nh-sub, phac-ada, ac-ada-d-phe, ac-ada-phe, dca-ada, dca-amc, nac-ada, ada-ada, or ch3—(ch2)10—co-ada, at the n-terminus and β-ala, amc, apa, ada, ae2a, ae4p, ε-lys(α-nh2), agm, lys(oct) or ahx, at the c-terminus.
U.s.a., Represented By The Department Of Veterans Affairs


06/16/16
20160166536 

Combination therapy for the treatment of cancer


Pharmaceutical compositions and methods of inhibiting tumor cell proliferation of triple-negative (er−/pr−/her2−) breast cancer cells and for treating subjects with a form of breast cancer having a triple-negative (er−/pr−/her2−) phenotype are provided. The methods include a step of contacting triple-negative breast cancer cells with an effective amount of a composition including eribulin and cyc065..
Northwestern University


06/09/16
20160159919 

Therapeutic agent comprising humanized anti-epiregulin antibody as active ingredient for non-small-cell lung carcinoma excluding adenocarcinoma


The present inventors successfully produced therapeutic agents for non-small cell lung cancer except adenocarcinoma, comprising as active ingredient an anti-epiregulin antibody that shows cross-species reactivity between the human animal and cynomolgus which is a non-human animal, an anti-epiregulin antibody with suppressed chemical degradation, an anti-epiregulin antibody with reduced isoelectric point, an anti-epiregulin antibody with increased midpoint temperature of thermal denaturation, or an anti-epiregulin antibody with reduced amount of aggregates, generated by appropriately substituting amino acid residues in the variable-region sequences of a humanized ep27 antibody that inhibits cancer cell proliferation by exerting a cytotoxicity and a neutralizing activity against human epiregulin-expressing cancer cells.. .
Miyagi Cancer Center Research Institute


06/09/16
20160159872 

Methods and compositions for treating cancer and inflammatory diseases


The invention provides a peptide construct comprising a cell penetrating peptide and an inhibitory peptide that interferes with the interaction between e1a and ctbp. The invention also provides related pharmaceutical composition comprising such a peptide construct.
The Regents Of The University Of Colorado, A Body Corporate


06/09/16
20160159861 

Apj receptor compounds


The invention relates generally to compounds which are allosteric modulators (e.g., negative and positive allosteric modulators, allosteric agonists, and ago-allosteric modulators) of the g protein coupled receptor apelin, also known as the apj receptor. The apj receptor compounds are derived from the it intracellular loop and domain of the apj receptor.
Anchor Therapeutics, Inc.


06/09/16
20160159843 

Nucleoside and nucleotide derivatives


Which inhibit, preventing or treating abnormal cellular proliferation and/or a viral infection, particularly by hiv, hcv or hbv. Consequently, the compounds of the present invention interfere with the replication cycle of a virus and are also useful as antiviral agents, or interfere with host cellular biochemical process and are also useful as antiproliferative agents.

06/09/16
20160158414 

Anisotropic constructs and methods for forming and using same for treating damaged biological tissue


Anisotropic constructs having a base member with a defined surface that includes a plurality of substantially parallel equidistant linear channels that are configured to modulate the polarity and proliferation of cells through spatial and biomechanical cues. The constructs are also capable of administering a biologically active agent and/or a pharmacological composition to tissue..
Cormatrix Cardiovascular, Inc.


06/09/16
20160158244 

Pharmaceutical compositions for the treatment of cancer and other diseases or disorders


Or a pharmaceutically acceptable salt thereof, that are suitable for the bulk production of an oral pharmaceutical dosage form; processes for the production of said oral pharmaceutical dosage form; and the use of the pharmaceutical composition for the treatment of patients suffering from or subject to diseases, disorders, or conditions involving cell survival, proliferation and migration, including chronic inflammatory proliferative disorders, proliferative ocular disorders, benign proliferative disorders, and cancer.. .

06/09/16
20160158163 

Method for treating gefitinib-resistant non-small-cell lung cancer


The present invention relates to a method for treating gefitinib-resistant non-small-cell lung cancer (nsclc) comprising administering an effective amount of a resveratrol analogue, (z)3,4,5,4′-tetramethoxystilbene (tms), to a subject in need thereof. The present invention also relates to a method for inducing apoptosis in gefitinib-resistant nsclc cells comprising contacting the resveratrol analogue to the cells at an effective amount.
Macau University Of Science And Technology


06/02/16
20160152582 

Therapeutic compounds


Or salts thereof are provided. Pharmaceutical compositions comprising a compound of formula i′, processes for preparing compounds of formula i′, intermediates useful for preparing compounds of formula i′ and therapeutic methods for treating the proliferation of the hiv virus, treating aids or delaying the onset of aids or arc symptoms in a mammal are also provided..

06/02/16
20160151460 

Method of treating skeletal dysplasias using vessel dilator


C-natriuretic peptide (cnp) has been shown to regulate proliferation of mouse and rat osteoblasts. Genetic deletion of cnp results in dwarfism.
United States Department Of Veterans Affairs


06/02/16
20160151430 

Composition for inducing proliferation or accumulation of regulatory t cells


It was found that bacteria belonging to the genus clostridium induce accumulation of regulatory t cells (treg cells) in the colon. Moreover, the present inventors found that regulatory t cells (treg cells) induced by from these bacteria suppressed proliferation of effector t-cells.
The University Of Tokyo


06/02/16
20160151424 

Amniotic membrane preparations and purified compositions and anti-inflammation methods


Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating tgf β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues.
Tissuetech, Inc.


06/02/16
20160151406 

Combination cancer therapy with c-met inhibitors and synthetic oligonucleotides


Methods of inhibiting, and preventing the proliferation of, cancer cells, as well as treating cancer in an individual (e.g., a liver cancer, for example hepatocellular carcinoma) can include providing both a synthetic mir-34 family molecule and a c-met inhibitor (e.g., tivantinib) to an individual in need thereof. The combination of the synthetic mirna molecule and c-met inhibitor can provide a desirable or superior effect, for example a more efficacious treatment than an alternative therapy, or the synthetic mirna molecule or c-met inhibitor alone.
Mirna Therapeutics, Inc.


06/02/16
20160151315 

S isomers of alpha-methyl-hydrocinnamic acid for the treatment of blood disorders


The present intervention generally relates to compositions comprising s-isomer of alpha-methyl-hydrocinnamic acid for the treatment and/or prevention of blood disorders and blood deficiencies, as well as methods for treating blood disorders and/or blood deficiency in a subject by administering a composition comprising s-isomer of alpha-methyl-hydrocinnamic acid to the subject to ameliorate at least one symptom associated with the blood disorder. Another aspect relates to administration of an s-isomer of alpha-methyl-hydrocinnamic acid stimulate multi-lineage hematopoietic cell production in a subject, for example, increasing the numbers of circulating neutrophils, erythrocytes and platelets.

06/02/16
20160151312 

Polyamine transport inhibitors as novel therapeutics


Novel polyamine transport inhibitors have been synthesized and demonstrated to block the uptake of native polyamines into human cancer cells. A combination therapy of the transport inhibitor and dfmo (a drug which blocks polyamine biosynthesis) provided synergistic activity against a metastatic human colon cancer cell line.
University Of Central Florida Research Foundation, Inc.


06/02/16
20160150774 

Device for sealing stagnant water tanks


A device for combating the proliferation of aquatic larvae in containers likely to hold stagnant water, the containers (1) including a wall (2) defining a cavity (3) and an open hole (4), and including an element (10) whose shape is designed to completely or partially conform to that of the wall (2) of the cavity and to seal the hole, the element being produced from a porous material permeable to air and to water, including a rubber granulate and a synthetic binder. The device made from porous material occupies the opening of the tank which can therefore no longer be freely accessed by mosquitoes.

05/26/16
20160145628 

Nanocarrier system for micrornas and uses thereof


Described herein are novel polyglycerol-amine polymeric nanocarriers in complex with micrornas and their uses in the treatment of cancer, in particular glioblastoma. Delivery of the polymeric nanocarriers in complex with micrornas in cell lines and in vivo inhibited cell proliferation, cell cycle progression, cell migration and tumor growth..
Rosetta Genomics Ltd.


05/26/16
20160145622 

Dengue virus-specific sirna, double helix oligo-rna structure comprising sirna, and composition for suppressing proliferation of dengue virus comprising rna structure


The present invention relates to a dengue virus-specific sirna, a double-stranded oligo rna structure comprising the sirna, and a composition for inhibiting dengue virus replication, which comprises the same, in which the double-stranded oligo rna structure comprises a hydrophilic compound and hydrophobic compound conjugated to both ends of the double-stranded rna (sirna) by a single covalent bond or a linker-mediated covalent bond so that they will be efficiently delivered into cells, and can be converted into nanoparticles by hydrophobic interactions between the double-stranded oligo rna structures in an aqueous solution. The sirna included in the double-stranded oligo rna structure acts specifically on all dengue virus serotypes.
Bioneer Corporation


05/26/16
20160145618 

Albumin production and cell proliferation


The present invention provides short activating rna molecules which up-regulate albumin production. The present invention also provides methods of up-regulating albumin production, such methods involving the use of short activating rna molecules capable of increasing the expression of albumin.
Mina Therapeutics Limited


05/26/16
20160145352 

Camelid single heavy-chain antibody directed against chromatin and uses of same


Disclosed is a polypeptide including a single-domain antibody directed against chromatin, derived from a heavy-chain antibody devoid of a camelid light chain (vhh) and capable of binding specifically with a complex of h2a and h2b histones. This polypeptide is particularly suitable for detecting/viewing chromatin in real time, without interfering with the rate of cell proliferation..
Universite Paul Sabatier Toulouse Iii


05/26/16
20160145302 

A short peptide targeting eps8 binding with egfr and use thereof


The present invention discloses a short peptide targeting eps8 binding with egfr and use thereof, and sequence of the short peptide is n′-arg-lys-lys-asn-lys-pro-pro-pro-pro-lys-lys-c′. The short peptide can effectively inhibit proliferation of eps8 positive tumors, and can also be used to make a pharmaceutical preparation for treating eps8 positive tumors, which has the potential of being developed into anti-cancer peptide inhibitor drugs..
Southern Medical University


05/26/16
20160144056 

Materials and methods for the treatment of pathological neovascularization in the eye


The subject invention provides materials and methods useful in safely and effectively preventing pathological proliferation of blood vessels. The prevention of the over-proliferation of blood vessels according to the subject invention is particularly advantageous for treatment of certain ocular conditions including age-related macular degeneration (amd), retinopathy of prematurity (rop) and diabetic retinopathy.
Florida Atlantic University Research Corporation


05/26/16
20160143969 

Gene-modified coxsackievirus


A modified coxsackievirus showing improved safety and/or aggressiveness to be used for oncolytic virotherapy is provided. A modified coxsackievirus showing tissue-specific suppression of proliferation and comprising a imitated genome consisting of the genome of coxsackievirus b3 wild-type (cvb3-wt) inserted with at least one polynucleotide consisting of a target sequence of tissue-specific micror na (mirna) is provided.
Kyushu University National University Corporation


05/26/16
20160143960 

Composition for inducing proliferation or accumulation of regulatory t cells


It was found that bacteria belonging to the genus clostridium induce accumulation of regulatory t cells (treg cells) in the colon. Moreover, the present inventors found that regulatory t cells (treg cells) induced by from these bacteria suppressed proliferation of effector t-cells.
The University Of Tokyo


05/26/16
20160143950 

Stem cells and stem cell factors for inhibiting the progression of alzheimer's disease


Therapeutic stem cells and methods for their use and manufacture. Stem cells are produced under conditions in which the stem cells are exposed to at least one environmental factor, including decreased oxygen tension.

05/26/16
20160143267 

Maintenance medium for primate pluripotent stem cells


Provided are a maintenance medium for primate pluripotent stem cells, and a method for preserving and a method for controlling proliferation of primate pluripotent stem cells using the medium. The maintenance medium for human pluripotent stem cells according to the present invention includes xylose as a saccharide..
Bourbon Corporation




Proliferation topics: Proliferation, Cell Proliferation, Differentiation, Cancer Cell, Antibodies, Progesterone, Specificity, Cancer Cells, Antimicrobial, Lymphocyte, Cell Differentiation, Homogeneous, Amino Acids, Wound Healing, Epithelial

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